diagnostic techniques and procedures

Summary

Summary: Methods, procedures, and tests performed to diagnose disease, disordered function, or disability.

Top Publications

  1. ncbi Resampling dependent concordance correlation coefficients
    John M Williamson
    Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    J Biopharm Stat 17:685-96. 2007
  2. ncbi Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews
    Johannes B Reitsma
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    J Clin Epidemiol 58:982-90. 2005
  3. ncbi The binomial distribution of meta-analysis was preferred to model within-study variability
    Taye H Hamza
    Department of Epidemiology and Biostatistics, Erasmus MC Erasmus University Medical Center, Rotterdam, The Netherlands
    J Clin Epidemiol 61:41-51. 2008
  4. ncbi The STARD statement for reporting studies of diagnostic accuracy: explanation and elaboration
    Patrick M Bossuyt
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Ann Intern Med 138:W1-12. 2003
  5. ncbi Towards complete and accurate reporting of studies of diagnostic accuracy: The STARD Initiative
    Patrick M Bossuyt
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Ann Intern Med 138:40-4. 2003
  6. ncbi The STARD statement for reporting studies of diagnostic accuracy: explanation and elaboration
    Patrick M Bossuyt
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    Clin Chem 49:7-18. 2003
  7. ncbi Sources of variation and bias in studies of diagnostic accuracy: a systematic review
    Penny Whiting
    University of York, York, United Kingdom
    Ann Intern Med 140:189-202. 2004
  8. doi Interpreting diagnostic test accuracy studies
    Patrick M M Bossuyt
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Semin Hematol 45:189-95. 2008
  9. pmc EMBASE search strategies for identifying methodologically sound diagnostic studies for use by clinicians and researchers
    Nancy L Wilczynski
    Health Information Research Unit, Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, L8N 3Z5 Canada
    BMC Med 3:7. 2005
  10. pmc Comparative accuracy: assessing new tests against existing diagnostic pathways
    Patrick M Bossuyt
    Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Centre, University of Amsterdam, Amsterdam 1100 DE, Netherlands
    BMJ 332:1089-92. 2006

Detail Information

Publications184 found, 100 shown here

  1. ncbi Resampling dependent concordance correlation coefficients
    John M Williamson
    Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    J Biopharm Stat 17:685-96. 2007
    ..Simulation results indicate that inference based on the bootstrap is valid, although type-I error rates are inflated for small sample sizes ( approximately 30). For illustration we analyze data from a carotid stenosis screening study...
  2. ncbi Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews
    Johannes B Reitsma
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    J Clin Epidemiol 58:982-90. 2005
    ..Studies of diagnostic accuracy most often report pairs of sensitivity and specificity. We demonstrate the advantage of using bivariate meta-regression models to analyze such data...
  3. ncbi The binomial distribution of meta-analysis was preferred to model within-study variability
    Taye H Hamza
    Department of Epidemiology and Biostatistics, Erasmus MC Erasmus University Medical Center, Rotterdam, The Netherlands
    J Clin Epidemiol 61:41-51. 2008
    ..This method can easily be performed in standard statistical packages. We investigate the performance of the standard method and the alternative approach...
  4. ncbi The STARD statement for reporting studies of diagnostic accuracy: explanation and elaboration
    Patrick M Bossuyt
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Ann Intern Med 138:W1-12. 2003
    ..Complete and informative reporting can only lead to better decisions in health care...
  5. ncbi Towards complete and accurate reporting of studies of diagnostic accuracy: The STARD Initiative
    Patrick M Bossuyt
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Ann Intern Med 138:40-4. 2003
    ..To comprehend the results of diagnostic accuracy studies, readers must understand the design, conduct, analysis, and results of such studies. That goal can be achieved only through complete transparency from authors...
  6. ncbi The STARD statement for reporting studies of diagnostic accuracy: explanation and elaboration
    Patrick M Bossuyt
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    Clin Chem 49:7-18. 2003
    ..Complete and informative reporting can only lead to better decisions in healthcare...
  7. ncbi Sources of variation and bias in studies of diagnostic accuracy: a systematic review
    Penny Whiting
    University of York, York, United Kingdom
    Ann Intern Med 140:189-202. 2004
    ..Studies of diagnostic accuracy are subject to different sources of bias and variation than studies that evaluate the effectiveness of an intervention. Little is known about the effects of these sources of bias and variation...
  8. doi Interpreting diagnostic test accuracy studies
    Patrick M M Bossuyt
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Semin Hematol 45:189-95. 2008
    ..We discuss the relativity of the claim that likelihood ratios are a superior way of expressing diagnostic accuracy, and defend the use of the sometimes downgraded sensitivity and specificity...
  9. pmc EMBASE search strategies for identifying methodologically sound diagnostic studies for use by clinicians and researchers
    Nancy L Wilczynski
    Health Information Research Unit, Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, L8N 3Z5 Canada
    BMC Med 3:7. 2005
    ..The objective of this study was to develop search strategies that optimize the retrieval of methodologically sound diagnostic studies from EMBASE for use by clinicians...
  10. pmc Comparative accuracy: assessing new tests against existing diagnostic pathways
    Patrick M Bossuyt
    Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Centre, University of Amsterdam, Amsterdam 1100 DE, Netherlands
    BMJ 332:1089-92. 2006
  11. pmc Evidence of bias and variation in diagnostic accuracy studies
    Anne W S Rutjes
    Deptartment of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    CMAJ 174:469-76. 2006
    ..We sought to determine and compare the direction and magnitude of the effects of a number of potential sources of bias and variation in studies on estimates of diagnostic accuracy...
  12. ncbi Bivariate meta-analysis of sensitivity and specificity with sparse data: a generalized linear mixed model approach
    Haitao Chu
    J Clin Epidemiol 59:1331-2; author reply 1332-3. 2006
  13. pmc Cost implications of improving malaria diagnosis: findings from north-eastern Tanzania
    Jacklin F Mosha
    National Institute for Medical Research, Mwanza, Tanzania
    PLoS ONE 5:e8707. 2010
    ..This paper attempts to estimate the rates of over diagnosis of malaria among children attending dispensaries in rural Tanzania and examines the potential cost implications of improving the quality of diagnosis...
  14. pmc Diagnostic tests 4: likelihood ratios
    Jonathan J Deeks
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, NSW 2006, Australia
    BMJ 329:168-9. 2004
  15. ncbi When is measuring sensitivity and specificity sufficient to evaluate a diagnostic test, and when do we need randomized trials?
    Sarah J Lord
    National Health and Medical Research Council Clinical Trials Centre, The University of Sydney, Sydney, Camperdown, NSW, Australia
    Ann Intern Med 144:850-5. 2006
    ....
  16. ncbi Challenges in systematic reviews of diagnostic technologies
    Athina Tatsioni
    Tufts New England Medical Center Evidence based Practice Center, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 142:1048-55. 2005
    ....
  17. ncbi Spectrum bias or spectrum effect? Subgroup variation in diagnostic test evaluation
    Stephanie A Mulherin
    University of North Carolina at Chapel Hill, Department of Epidemiology, Chapel Hill, NC 27599 7435, USA
    Ann Intern Med 137:598-602. 2002
    ..Furthermore, clinicians should consider study samples carefully to determine whether results are generalizable to their specific patient population...
  18. ncbi Three approaches to regression analysis of receiver operating characteristic curves for continuous test results
    M S Pepe
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington 98104, USA
    Biometrics 54:124-35. 1998
    ..It is hoped that the presentation in this paper will both encourage the use of regression analysis for evaluating diagnostic tests and help guide the choice of the most appropriate regression analysis approach in applications...
  19. ncbi There is nothing staid about STARD: progress in the reporting of diagnostic accuracy studies
    Karen C Johnston
    Neurology 67:740-1. 2006
  20. pmc The predictive receiver operating characteristic curve for the joint assessment of the positive and negative predictive values
    Shang Ying Shiu
    Institute of Statistical Science, Academia Sinica, Taipei 115, Taiwan, Republic of China
    Philos Trans A Math Phys Eng Sci 366:2313-33. 2008
    ..We also formulate and discuss regression models for the estimation of the effects of covariates...
  21. ncbi Sensitivity and specificity should be de-emphasized in diagnostic accuracy studies
    Karel G M Moons
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, PO Box 80035, 3508 TA Utrecht, The Netherlands
    Acad Radiol 10:670-2. 2003
  22. pmc Conducting systematic reviews of diagnostic studies: didactic guidelines
    Walter L Deville
    Institute for Research in Extramural Medicine EMGO Institute, VU University Medical Centre, Amsterdam, The Netherlands
    BMC Med Res Methodol 2:9. 2002
    ..Although guidelines for critical appraisal of diagnostic research and meta-analyses have already been published, these may be difficult to understand for clinical researchers or do not provide enough detailed information...
  23. doi QUADOMICS: an adaptation of the Quality Assessment of Diagnostic Accuracy Assessment (QUADAS) for the evaluation of the methodological quality of studies on the diagnostic accuracy of '-omics'-based technologies
    Blanca Lumbreras
    Public Health Department, Miguel Hernandez University, Alicante, Spain
    Clin Biochem 41:1316-25. 2008
    ..To adapt the Quality Assessment of Diagnostic Accuracy Assessment (QUADAS) to the particular methodological challenges posed by research on '-omics'-based diagnostic tests...
  24. ncbi Associating explanatory variables with summary receiver operating characteristic curves in diagnostic meta-analysis
    Taye Hussein Hamza
    Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands
    J Clin Epidemiol 62:1284-91. 2009
    ....
  25. ncbi Spectrum bias: a quantitative and graphical analysis of the variability of medical diagnostic test performance
    Catherine Goehring
    Clinical Epidemiology Division, University Hospital, Geneva, Switzerland
    Stat Med 23:125-35. 2004
    ..We conclude that spectrum effect is more common than spectrum bias and that clinical decisions are affected only under certain conditions...
  26. ncbi Empirical Bayes estimates generated in a hierarchical summary ROC analysis agreed closely with those of a full Bayesian analysis
    Petra Macaskill
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, NSW 2006, Australia
    J Clin Epidemiol 57:925-32. 2004
    ..The objective of this report is to show how the model may be fitted using the SAS procedure NLMIXED and to compare the results to the fully Bayesian analysis using an example...
  27. ncbi Reducing the burden of childhood malaria in Africa: the role of improved
    Maria E Rafael
    RAND Corporation, 1776 Main Street, PO Box 2138, Santa Monica, California 90401 2138, USA
    Nature 444:39-48. 2006
  28. pmc Communicating accuracy of tests to general practitioners: a controlled study
    Johann Steurer
    Horten Zentrum für praxisorientierte Forschung und Wissenstransfer, Universitatsspital Zurich, Bolleystrasse 40, Postfach Nord, CH 8091 Zurich, Switzerland
    BMJ 324:824-6. 2002
    ..To assess the extent to which different forms of summarising diagnostic test information influence general practitioners' ability to estimate disease probabilities...
  29. ncbi Modified exact sample size for a binomial proportion with special emphasis on diagnostic test parameter estimation
    Geoffrey T Fosgate
    Department of Veterinary Anatomy and Public Health, College of Veterinary Medicine, Texas A and M University, College Station, 77843 4458, USA
    Stat Med 24:2857-66. 2005
    ..This algorithm resulted in sample sizes that achieved the appropriate confidence interval width even in situations when normal approximation methods performed poorly...
  30. ncbi Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative
    Patrick M Bossuyt
    Academic Medical Center, Department of Clinical Epidemiology, University of Amsterdam, Amsterdam, The Netherlands
    Clin Chem Lab Med 41:68-73. 2003
    ..To improve the accuracy and completeness of reporting of studies of diagnostic accuracy, to allow readers to assess the potential for bias in the study and to evaluate its generalisability...
  31. ncbi Assessing observer agreement in studies involving replicated binary observations
    Michael Haber
    Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    J Biopharm Stat 17:757-66. 2007
    ..The reliability of the estimation method is examined via a simulation study. Data from a study aimed at determining the validity of diagnosis of breast cancer based on mammograms is used to illustrate the new concepts and methods...
  32. ncbi Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative
    Patrick M Bossuyt
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Fam Pract 21:4-10. 2004
    ..Our aim was to improve the accuracy and completeness of reporting of studies of diagnostic accuracy in order to allow readers to assess the potential for bias in a study and to evaluate the generalizability of its results...
  33. ncbi A class of repeated measures concordance correlation coefficients
    Tonya S King
    Pennsylvania State University College of Medicine, Pennsylvania 17033, USA
    J Biopharm Stat 17:653-72. 2007
    ....
  34. ncbi General radiologists' diagnostic accuracy: incomplete presentation of data casts doubt on study's conclusions
    Marilyn T Zivian
    AJR Am J Roentgenol 184:697-9. 2005
  35. ncbi [Evaluation of diagnostic methods]
    F Doyon
    Institut Gustave Roussy, , 39, rue Camille Desmoulins, 94805 Villejuif
    J Radiol 82:117-25. 2001
    ..CONCLUSION: The tools required to evaluate diagnostic tests rigorously are available and simple. They should be used more often...
  36. ncbi Diagnostic accuracy of the Triage D-dimer test for exclusion of venous thromboembolism in outpatients
    Timothy Ghys
    Department of Hematology, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, B 1090 Brussels, Belgium
    Thromb Res 121:735-41. 2008
    ..We evaluated the diagnostic performance of the Triage D-dimer test, a new fast quantitative point-of-care whole blood D-dimer assay and compared it with the Vidas D-dimer assay...
  37. ncbi Toward complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative
    Patrick M Bossuyt
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Acad Radiol 10:664-9. 2003
    ..The authors sought to develop guidelines for improving the accuracy and completeness of reporting of studies of diagnostic accuracy in order to allow readers better to assess the validity and generalizability of study results...
  38. ncbi Measuring diagnostic and predictive accuracy in disease management: an introduction to receiver operating characteristic (ROC) analysis
    Ariel Linden
    Linden Consulting Group, Portland, OR 97124, USA
    J Eval Clin Pract 12:132-9. 2006
    ..Therefore the implementation of ROC as an evaluation tool should be strongly considered in the various phases of a DM programme...
  39. ncbi Assessing individual agreement
    Huiman X Barnhart
    Department of Biostatistics and Bioinformatics, Duke Clinical Research Institute, Duke University, Durham, North Carolina 27715, USA
    J Biopharm Stat 17:697-719. 2007
    ..A method of moments is used for estimation, where one can utilize output from ANOVA models. The nonparametric and bootstrap approaches are used for inference. Five examples are used for illustration...
  40. ncbi Comparison of concordance correlation coefficient and coefficient of individual agreement in assessing agreement
    Huiman X Barnhart
    Department of Biostatistics and Bioinformatics, Duke Clinical Research Institute, Duke University, Durham, North Carolina 27715, USA
    J Biopharm Stat 17:721-38. 2007
    ..The relationship between CCC and CIA as well as the impact of between-subject variability are presented algebraically and graphically. Several examples are presented to explain the interpretation of the CCC and CIA values...
  41. ncbi Medical errors as a result of specialization
    Ahmad Hashem
    Healthcare Industry Solutions Group, Microsoft Corporation, One Microsoft Way, Redmond, WA 98052, USA
    J Biomed Inform 36:61-9. 2003
    ..Specialists generate more diagnostic hypotheses within their domain than outside, and assign higher probabilities to diagnoses within that domain...
  42. ncbi Application of summary receiver operating characteristics (sROC) analysis to diagnostic clinical testing
    A S Rosman
    Section of Gastroenterology and Medicine Program, James J Peters VAMC, Bronx, NY 10468, USA
    Adv Med Sci 52:76-82. 2007
    ..Statistical formulas can compare these values from different diagnostic tests. With the introduction of sROC software and better understanding of this method, the application of sROC analysis should continue to increase...
  43. ncbi Regression models for method comparison data
    Graham Dunn
    Biostatistics Group, Division of Epidemiology and Health Sciences, University of Manchester, Manchester, UK
    J Biopharm Stat 17:739-56. 2007
    ..Large samples are frequently needed and two-phase sampling methods are introduced to improve the efficiency of the IV estimators...
  44. ncbi A practical approach to the diagnosis of growth hormone (GH) deficiency in patients transitioning to adulthood using GH stimulation testing
    Dennis M Styne
    Department of Pediatric Endocrinology, University of California Davis School of Medicine, Sacramento, CA 95817, USA
    J Pediatr Endocrinol Metab 16:637-43. 2003
    ..Thus the choice of testing methods impacts the diagnosis of GHD in transition patients...
  45. ncbi Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative
    Patrick M Bossuyt
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center University of Amsterdam, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    AJR Am J Roentgenol 181:51-5. 2003
    ..To improve the accuracy and completeness of reporting of studies of diagnostic accuracy in order to allow readers to assess the potential for bias in a study and to evaluate the generalisability of its results...
  46. pmc Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative
    Patrick M Bossuyt
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, Netherlands
    BMJ 326:41-4. 2003
    ..To improve the accuracy and completeness of reporting of studies of diagnostic accuracy, to allow readers to assess the potential for bias in a study, and to evaluate a study's generalisability...
  47. ncbi [Reporting studies of diagnostic accuracy according to a standard method; the Standards for Reporting of Diagnostic Accuracy (STARD)]
    P M Bossuyt
    Academisch Medisch Centrum Universiteit van Amsterdam, Afd Klinische Epidemiologie en Biostatistiek, Postbus 22 700, 1100 DE Amsterdam
    Ned Tijdschr Geneeskd 147:336-40. 2003
    ..Use of the checklist and flow diagram will improve the quality of reports produced, to the advantage of clinicians, researchers, reviewers, journal editors and other interested parties...
  48. ncbi Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative. Standards for Reporting of Diagnostic Accuracy
    Patrick M Bossuyt
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    Clin Chem 49:1-6. 2003
    ..To comprehend the results of diagnostic accuracy studies, readers must understand the design, conduct, analysis, and results of such studies. That goal can be achieved only through complete transparency from authors...
  49. ncbi Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative
    Patrick M Bossuyt
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    Clin Biochem 36:2-7. 2003
    ..To improve the accuracy and completeness of reporting of studies of diagnostic accuracy in order to allow readers to assess the potential for bias in the study and to evaluate its generalisability...
  50. ncbi Toward complete and accurate reporting of studies of diagnostic accuracy. The STARD initiative
    Patrick M Bossuyt
    Dept of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Am J Clin Pathol 119:18-22. 2003
    ..If medical journals adopt the checklist and the flow diagram, the quality of reporting of studies of diagnostic accuracy should improve, to the advantage of clinicians, researchers, reviewers, journals, and the public...
  51. ncbi Towards complete and accurate reporting of studies of diagnostic accuracy: The STARD Initiative
    Patrick M Bossuyt
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, The Netherlands
    Radiology 226:24-8. 2003
    ..To improve the accuracy and completeness of reporting of studies of diagnostic accuracy, to allow readers to assess the potential for bias in the study and to evaluate its generalisability...
  52. ncbi Evidence-based laboratory medicine: addressing bias, generalisability and applicability in studies on diagnostic accuracy. The STARD initiative
    Matthew McQueen
    Clin Chem Lab Med 41:1. 2003
  53. pmc Misguided efforts and future challenges for research on "diagnostic tests"
    A R Feinstein
    Yale University School of Medicine, New Haven, USA
    J Epidemiol Community Health 56:330-2. 2002
  54. ncbi Reporting studies of diagnostic accuracy: the STARD initiative
    Roger Jones
    Fam Pract 21:3. 2004
  55. ncbi Do we need a checklist for reporting the results of diagnostic test evaluations? The STARD proposal
    Constantine Gatsonis
    Acad Radiol 10:599-600. 2003
  56. ncbi A grey zone for quantitative diagnostic and screening tests
    Joel Coste
    Département de Biostatistique, Pavillon Saint Jacques, Hopital Cochin, 27 rue du Faubourg Saint Jacques, 75674 Paris Cedex 14, France
    Int J Epidemiol 32:304-13. 2003
    ..This partition intentionally includes a grey zone between positive and negative conclusions...
  57. ncbi A fast, simple, and inexpensive method to collect exhaled breath condensate for pH determination
    Philippe Prince
    Unité de Recherche en Pneumologie, Centre de Recherche de l Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Quebec, Quebec, Canada
    Ann Allergy Asthma Immunol 97:622-7. 2006
    ..Exhaled breath condensate (EBC) analysis is a noninvasive method for assessing lower airway inflammation. Various methods of collecting EBC have been described. However, they are often time-consuming or involve expensive equipment...
  58. ncbi Comparative validity of three screening questionnaires for DSM-IV depressive disorders and physicians' diagnoses
    Bernd Löwe
    Department of General Internal and Psychosomatic Medicine, University of Heidelberg, Medical Hospital, Bergheimer Strasse 58, D 69115, Heidelberg, Germany
    J Affect Disord 78:131-40. 2004
    ....
  59. ncbi The sensitivity of the Malay version of Brief Manual of Sexual Function Inventory in assessing erectile dysfunction secondary to benign prostatic hyperplasia
    K F Quek
    Health Research Development Unit, University Malaya Medical Centre, 50603 Kuala Lumpur
    Med J Malaysia 58:356-64. 2003
    ..The Mal-BMSFI is a suitable, reliable, valid and sensitive to clinical change in the Malaysian population...
  60. ncbi Results of diagnostic accuracy studies are not always validated
    Ann Van den Bruel
    Department of General Practice ACHG, Katholieke Universiteit Leuven, Kapucijnenvoer 33, Blok J, 3000 Leuven, Belgium
    J Clin Epidemiol 59:559-66. 2006
    ..Here we describe whether diagnostic research is validated, which technique is used, and to what extent the validation study results differ from the original...
  61. ncbi Automated analytical microarrays: a critical review
    Michael Seidel
    Chair for Analytical Chemistry and Institute of Hydrochemistry, Technische Universitat Munchen, Marchioninistrasse 17, 81377, Munchen, Germany
    Anal Bioanal Chem 391:1521-44. 2008
    ..This review gives an overview of the current research on microarrays with the focus on automated systems and quantitative multiplexed applications...
  62. ncbi Agreement between methods of measurement with multiple observations per individual
    J Martin Bland
    Department of Health Sciences, University of York, York, UK
    J Biopharm Stat 17:571-82. 2007
    ..In this paper we describe methods for analysing such clustered observations, both when the underlying quantity is assumed to be changing and when it is not...
  63. ncbi Protein profiling as a diagnostic tool in clinical chemistry: a review
    Judith A P Bons
    Department of Clinical Chemistry, University Hospital Maastricht, Maastricht, The Netherlands
    Clin Chem Lab Med 43:1281-90. 2005
    ..Further progress in protein profiling as a diagnostic tool requires a more comprehensive description of technical details in all future studies...
  64. ncbi Diagnostic accuracy of flow rate testing in urology
    H R H Patel
    Institute of Urology and Nephrology, University College London Medical School, London, UK
    BJU Int 92:58-63. 2003
    ..To highlight the importance of methodological standards in diagnostic testing in urology, by reviewing the extent of compliance with these standards in reports of published evaluations...
  65. ncbi [Using characteristic numbers to estimate the usefulness of laboratory tests for diagnosis]
    Matti Uhari
    Oulun yliopiston lastentautien klinikka PL 5000, 90014 Oulun yliopisto
    Duodecim 120:935-41. 2004
  66. ncbi Assessment of the accuracy of diagnostic tests: the cross-sectional study
    J A Knottnerus
    University of Maastricht, Netherlands School of Primary Care Research, Post Office Box 616, 6200 MD Maastricht, The Netherlands
    J Clin Epidemiol 56:1118-28. 2003
    ..Also, systematic reviews and meta-analysis have a role. To enable readers of diagnostic research reports to evaluate whether methodological key issues were addressed, authors are advised to follow the STARD guidelines...
  67. ncbi A high performance liquid chromatographic method for the measurement of total carnitine in human plasma and urine
    Christopher J McEntyre
    Biochemistry Unit, Canterbury Health Laboratories, P O Box 151, Christchurch, New Zealand
    Clin Chim Acta 344:123-30. 2004
    ..Advantages of this method include good precision, accuracy and linearity, the use of fluorescence to gain sensitivity, the small sample volume required and a relatively low sample preparation time...
  68. ncbi [Recent advance in diagnostic telepathology]
    Xin xia Li
    Zhonghua Bing Li Xue Za Zhi 35:176-8. 2006
  69. ncbi Diagnostic accuracy of clinical tests for the different degrees of subacromial impingement syndrome
    Hyung Bin Park
    Department of Orthopaedic Surgery, College of Medicine, Gyeong Sang National University, 90 Chilamdong 660 751, Jinju, South Korea
    J Bone Joint Surg Am 87:1446-55. 2005
    ..The hypothesis of this study was that the degree of severity of rotator cuff disease affects the diagnostic values of the commonly used clinical tests...
  70. ncbi [Diagnostics: new methodological initiatives]
    Erik Magid
    Amager Hospital, Klinisk Biokemisk Afdeling
    Ugeskr Laeger 166:1664-6. 2004
  71. ncbi New methods in the assessment of diagnostic procedures
    Jos Kleijnen
    Kleijnen Systematic Reviews Limited, York, England
    Z Arztl Fortbild Qualitatssich 100:519-25. 2006
    ..Diagnostic research needs careful consideration of the clinical situation, and should take into account that diagnosis is a multivariable process. Various study designs to evaluate diagnostic procedures are presented...
  72. ncbi Accuracy of diagnostic tests read with and without clinical information: a systematic review
    Clement T Loy
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, Sydney, Australia
    JAMA 292:1602-9. 2004
    ..Although it is common practice to read tests with clinical information, whether this improves or decreases the accuracy of test reading is uncertain...
  73. pmc The use of "overall accuracy" to evaluate the validity of screening or diagnostic tests
    Anthony J Alberg
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Gen Intern Med 19:460-5. 2004
    ..We assessed the value of overall accuracy in studies of test validity, a topic that has not received adequate emphasis in the clinical literature...
  74. ncbi A systematic review of the clinical diagnostic tests for carpal tunnel syndrome
    N Massy Westropp
    School of Occupational Therapy, University of South Australia, North Terrace, Adelaide, South Australia
    J Hand Surg Am 25:120-7. 2000
    ..Many reports do not include methodology, which makes the results difficult to reproduce and to apply to other populations. (J Hand Surg 2000; 25A:120-127...
  75. ncbi The STARD initiative: a possible link to diagnostic accuracy and reduction in medical error
    M J McQueen
    Ann Clin Biochem 40:307-8. 2003
  76. ncbi User's guide to the surgical literature: how to use an article about a diagnostic test
    Mohit Bhandari
    Department of Clinical Epidemiology and Biostatistics, McMaster University Health Sciences Center, 1200 Main Street West, Hamilton, ON L8N 3Z5, Canada
    J Bone Joint Surg Am 85:1133-40. 2003
  77. ncbi Idiopathic infantile asymmetry, proposal of a measurement scale
    Heike Philippi
    University Children s Hospital, Johannes Gutenberg University, Langenbeckstr 1 55101 Mainz, Germany
    Early Hum Dev 80:79-90. 2004
    ..Statistical analysis indicated good reliability and consistency of the testing method with an intraclass correlation coefficient of 91.5% (Cronbach alpha 0.84)...
  78. ncbi Three principles to define the success of a diagnostic study could be identified
    Werner Vach
    Clinical Epidemiology, Institute of Medical Biometry and Medical Informatics, Freiburg University Medical Center, Freiburg, Germany
    J Clin Epidemiol 65:293-300. 2012
    ..Diagnostic studies are typically studies with two endpoints, sensitivity and specificity. To define the success of a diagnostic study, results for these two endpoints have to be combined in an appropriate manner...
  79. doi Efficacy assessment in paediatric studies
    Siri Wang
    Norwegian Medicines Agency, Tønsberg Hospital Pharmacy, Sven Oftedalsvei 6, N 0950 Oslo, Norway
    Handb Exp Pharmacol 205:149-68. 2011
    ..Collaboration between the academic researchers, pharmaceutical industry, and regulatory authorities is needed to meet the challenges in proper validation of biomarkers and surrogate endpoints in paediatric trials...
  80. pmc Identification and characterization of DM1 patients by a new diagnostic certified assay: neuromuscular and cardiac assessments
    Rea Valaperta
    Research Laboratories Molecular Biology, IRCCS Policlinico San Donato, Piazza E Malan 2, San Donato Milanese, 20097 Milan, Italy
    Biomed Res Int 2013:958510. 2013
    ..Our findings suggest that this assay appears to be a very robust and reliable molecular test, showing high reproducibility and giving an unambiguous interpretation of results...
  81. ncbi Incoming resident experience and comfort with procedures designated as "basic"
    William Murdoch
    Family Medicine Residency Program, Wayne State University, Rochester Hills, MI 48307, USA
    Fam Med 44:47-50. 2012
    ..The consensus documentation suggestions are based on expectations of procedural training prior to residency. Few studies have evaluated the perceived baseline level of procedural competency prior to residency training...
  82. doi Pedographic classification and ulcer detection in the diabetic foot
    Ute Waldecker
    Hufeland Klinik, Orthopedic Department, Taunusallee 5, 56130 Bad Ems, Germany
    Foot Ankle Surg 18:42-9. 2012
    ..Plantar pressure is a cause of foot ulceration in diabetes. Attempts to determine a pressure threshold have failed. The aim of this study was to determine a pedographic classification to identify patients at risk for a foot ulcer...
  83. ncbi Salivary diagnostics: moving to the next level
    Ole Brinkmann
    University of California at Los Angeles, Dental Research Institute, USA
    Dent Today 31:54, 56-7; quiz 58-9. 2012
    ..This is a unique moment where dentistry may be paving a new path for primary healthcare...
  84. pmc Evidence base of clinical diagnosis: Rational, cost effective use of investigations in clinical practice
    Ron Winkens
    Department of General Practice and Transmural Care Unit, University Hospital, 6200 MD Maastricht, Netherlands
    BMJ 324:783. 2002
  85. ncbi [Induced sputum--new face of an old method]
    Małgorzata Korniluk
    Kliniki Chorób Płuc i Gruźlicy Akademii Medycznej w Białymstoku
    Pneumonol Alergol Pol 70:518-22. 2002
  86. ncbi The place of marker vaccines in control and eradication of animal diseases--aspects of comparative interest
    P P Pastoret
    Institute for Animal Health, Compton Laboratory, Newbury, Berks, UK
    Dev Biol (Basel) 121:181-8. 2005
    ..Current control and eradication programmes against these and other diseases, the role of marker vaccines, and the limitations of such programmes are being discussed...
  87. ncbi C-reactive protein level as a predictor of transient vs. sustained anticardiolipin antibody positivity
    Orit Twito
    Department of Internal Medicine A, Meir Hospital, Kfar Saba and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Eur J Haematol 76:206-9. 2006
    ..Our results suggest that the hs-CRP test may be useful in the assessment of patients with a positive aCL antibody test. A concurrently performed negative hs-CRP test result may be useful in making diagnostic and therapeutic decisions...
  88. ncbi Economic consequence of immediate testing for C-reactive protein and leukocyte count in new outpatients with acute infection
    Yuzuru Takemura
    Department of Laboratory Medicine, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Clin Chim Acta 360:114-21. 2005
    ..There have been few well-designed studies that assess the cost-effectiveness of near-patient immediate testing...
  89. ncbi Development of a one-step strip test for the diagnosis of chicken infectious bursal disease
    Gai Ping Zhang
    Institute of Biotechnology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China
    Avian Dis 49:177-81. 2005
    ..It takes only 1-2 min to do a strip test to detect chicken IBDV antigen after the specimen is grounded in a whirl pack with finger massage...
  90. ncbi Multisite evaluation of a new dipstick for albumin, protein, and creatinine
    J F Wallace
    Diagnostics Business Group, Bayer Corporation, Elkhart, Indiana 46530, USA
    J Clin Lab Anal 15:231-5. 2001
    ..Compared to reading by eye, the dipstick results agreed better with the quantitative assays when they were read by a reflectometer (Bayer Clinitek)...
  91. doi Predicting possible zonisamide hypersensitivity syndrome
    Manuela G Neuman
    In Vitro Drug Safety and Biotechnology Laboratory, MaRS Discovery Centre, University of Toronto, Toronto, ON, Canada
    Exp Dermatol 17:1045-51. 2008
    ..The second aim was to determine age-related differences in ZNS-induced HSR. LTA was previously validated in patients who received sulphamethoxazole (SMX) or AC...
  92. pmc Estimates of sensitivity and specificity can be biased when reporting the results of the second test in a screening trial conducted in series
    Brandy M Ringham
    Department of Biostatistics, Colorado School of Public Health, University of Colorado, Denver, Aurora, CO, USA
    BMC Med Res Methodol 10:3. 2010
    ..The problem is further complicated when some cases are misclassified as non-cases due to incomplete disease status ascertainment...
  93. ncbi Diagnosing early rheumatoid arthritis (RA). What are the problems and opportunities?
    H R Schumacher
    Department of Rheumatology, University of Pennsylvania Hospital, 3rd Ravdin Building, 34th and Spruce Street, Philadelphia, Pennsylvania, USA
    Clin Exp Rheumatol 21:S15-9. 2003
    ..We review this area, focusing on work from our own research and how this has guided our thinking...
  94. ncbi [The Danish clinical guidelines (Klaringsrapporter, 1996-2001: Insufficient evidence presented for the diagnostic accuracy of recommended clinical-biochemical tests]
    Per E Jørgensen
    Odense Universitetshospital, Afdeling KKA
    Ugeskr Laeger 166:1667-70. 2004
  95. ncbi [The current method of handling of test samples and medical reimbursement for POCT in Japan]
    Naoto Shimetani
    Department of Clinical Pathology, Koshigaya Hospital, Dokkyo University School of Medicine, Koshigaya 343 8555
    Rinsho Byori 50:958-64. 2002
    ..Recent technological innovation has provided a wide variety of POCT products that do not require medical equipment or reagents. Further development of novel, innovative POCT procedures in the near future is promising...
  96. doi Interactive diagnostics in the indication to allogeneic SCT in AML
    U Bacher
    Clinic for Stem Cell Transplantation, University Cancer Center Hamburg, Hamburg, Germany
    Bone Marrow Transplant 43:745-56. 2009
    ..Thus, the optimization of the indication to allo-SCT is an ongoing process that should remain in continuous interaction with the increasing panel of known genetic markers and diagnostic methods...
  97. ncbi Lessons from Kitty Hawk: from feasibility to routine clinical use for the field of proteomic pattern diagnostics
    Emanuel F Petricoin
    FDA NCI Clinical Proteomics Program, Office of Cell and Gene Therapies, CBER, FDA, Bethesda, MD 20892, USA
    Proteomics 4:2357-60. 2004
    ..We reflect on the important lessons gleaned from the Wright brothers' attempts at controlled heavier-than-air flight as a model for perseverance and a view to the very near future for proteomic pattern diagnostics...
  98. ncbi [Roaming through methodology. XXXII. False test results]
    T van der Weijden
    Universiteit Maastricht, capaciteitsgroep Huisartsgeneeskunde, Postbus 616, 6200 MD Maastricht
    Ned Tijdschr Geneeskd 145:906-8. 2001
    ..The patient should be aware that a perfectly conclusive diagnostic test is rare in medical practice, and should more often be informed of the implications of false-positive and false-negative test results...
  99. ncbi Image processing, diagnostic information extraction and quantitative assessment in pathology
    Alfredo Santinelli
    Department of Pathology and Laboratory, University of Ancona School of Medicine, Torrette di Ancona, Italy
    J Cell Mol Med 6:93-106. 2002
    ..While one certainly would not dispute the value of statistical procedures, the clinical needs call for individual patient targeted prognosis...
  100. pmc Conditional estimation of sensitivity and specificity from a phase 2 biomarker study allowing early termination for futility
    Margaret Sullivan Pepe
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M2 B500, Seattle, WA 98109, U S A
    Stat Med 28:762-79. 2009
    ..The conditional-UMVUE appears to be a very good choice...
  101. ncbi [Application of alpha-fetoprotein in the diagnosis of hepatocellular carcinoma]
    Hu Liang Jia
    Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 30:440-3. 2008
    ..To evaluate the usefulness of serum alpha-fetoprotein (AFP) in clinical diagnosis and screening for hepatocellular carcinoma (HCC)...

Research Grants104 found, 100 shown here

  1. Considerations of covariates in biomarker studies
    Margaret S Pepe; Fiscal Year: 2010
    ..Programs written in Stata will be made available through the Stata archive, the EDRN and through a 'Diagnostics and Biomarkers Statistical Center'web site. ..
  2. STATISTICAL METHODS FOR MEDICAL DIAGNOSTIC STUDIES
    Margaret Pepe; Fiscal Year: 2000
    ..Software to implement analyses will use standard statistical packages when possible and will be fully documented so that it can be shared with colleagues. ..
  3. Statistical Methods for Medical Tests and Biomarkers
    Margaret Pepe; Fiscal Year: 2007
    ..Relative to our previous submission, Aims 1 and 5 have been eliminated while aims 2, 3 and 4 have been elaborated upon and expanded. ..
  4. Statistical Methods for Medical Tests and Biomarkers
    Margaret Pepe; Fiscal Year: 2002
    ..abstract_text> ..
  5. Considerations of covariates in biomarker studies
    Margaret Pepe; Fiscal Year: 2008
    ..Programs written in Stata will be made available through the Stata archive, the EDRN and through a 'Diagnostics and Biomarkers Statistical Center' web site. ..
  6. STATISTICAL METHODS FOR MEDICAL DIAGNOSTIC STUDIES
    Margaret Pepe; Fiscal Year: 2001
    ..Software to implement analyses will use standard statistical packages when possible and will be fully documented so that it can be shared with colleagues. ..
  7. Statistical Methods for Medical Tests and Biomarkers
    Margaret Pepe; Fiscal Year: 2008
    ..Relative to our previous submission, Aims 1 and 5 have been eliminated while aims 2, 3 and 4 have been elaborated upon and expanded. ..
  8. Statistical Methods for Medical Tests and Biomarkers
    Margaret Pepe; Fiscal Year: 2005
    ..abstract_text> ..
  9. Statistical Methods for Medical Tests and Biomarkers
    Margaret Pepe; Fiscal Year: 2003
    ..abstract_text> ..
  10. Statistical Methods for Medical Tests and Biomarkers
    Margaret Pepe; Fiscal Year: 2009
    ..Relative to our previous submission, Aims 1 and 5 have been eliminated while aims 2, 3 and 4 have been elaborated upon and expanded. ..
  11. Considerations of covariates in biomarker studies
    Margaret Pepe; Fiscal Year: 2009
    ..Programs written in Stata will be made available through the Stata archive, the EDRN and through a 'Diagnostics and Biomarkers Statistical Center'web site. ..
  12. Statistical Methods for Medical Tests and Biomarkers
    Margaret S Pepe; Fiscal Year: 2010
    ..Relative to our previous submission, Aims 1 and 5 have been eliminated while aims 2, 3 and 4 have been elaborated upon and expanded. ..
  13. Statistical Methods for Medical Tests and Biomarkers
    Margaret Pepe; Fiscal Year: 2004
    ..abstract_text> ..
  14. STATISTICAL METHODS FOR MEDICAL DIAGNOSTIC STUDIES
    Margaret Pepe; Fiscal Year: 1999
    ..Software to implement analyses will use standard statistical packages when possible and will be fully documented so that it can be shared with colleagues. ..
  15. A New Biomarker for Ovarian Cancer Detection
    Eleftherios Diamandis; Fiscal Year: 2003
    ..In this grant proposal, we describe further studies, which will examine in greater detail, the ability of a test for the amount of this protein in blood to correctly diagnose the presence of ovarian cancer. ..
  16. Diagnosing Acute Bacterial Sinusitis in Children and Measuring Treatment Response
    Nader Shaikh; Fiscal Year: 2008
    ..In addition, we will also develop a symptom scale which will allow researchers to compare the effectiveness of different treatment strategies for children with acute bacterial sinusitis. ..
  17. Consequences and Course of Uterine Fibroids in Pregnancy
    Katherine Hartmann; Fiscal Year: 2005
    ..By prospectively investigating fibroid characteristics and risk, this research has potential to inform care for many women with fibroids who are pregnant or planning pregnancy. ..
  18. Assessing Treatment-Related Harms in Prostate Cancer
    H Welch; Fiscal Year: 2005
    ..The entire process will be repeated on a cohort of men who receive a transurethral resection of the prostate. ..
  19. Non-steroidal anti-inflammatory use and miscarriage
    Katherine Hartmann; Fiscal Year: 2006
    ....
  20. Consequences and Course of Uterine Fibroids in Pregnancy
    Katherine Hartmann; Fiscal Year: 2008
    ..By prospectively investigating fibroid characteristics and risk, this research has potential to inform care for many women with fibroids who are pregnant or planning pregnancy. ..
  21. New Methods for Evaluating Interobserver Agreement
    Michael Haber; Fiscal Year: 2006
    ..Existing and new agreement indices will be compared and linked. All the proposed methods will be applied to real data sets from the behavioral and biomedical sciences. [unreadable] [unreadable]..
  22. Medical Image Perception Society Confrence XI
    Elizabeth Krupinski; Fiscal Year: 2005
    ..abstract_text> ..
  23. SUBTLE DISTURBANCES OF COBALAMIN STATUS
    Ralph Carmel; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  24. Translational Research in the Dystrophinopathies
    Kevin Flanigan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  25. Improving Heart Failure Risk Stratification in the ED
    Alan Storrow; Fiscal Year: 2007
    ..In collaboration with outcomes and effectiveness researchers, we plan to conduct further studies to test the efficacy of our risk model. ..
  26. Research Training on Service Systems for Persons w/AIDS
    Oscar Grusky; Fiscal Year: 2007
    ..The program has close ties to the Center for HiV Identification, Prevention, and Treatment Services, an NIMH-sponsored prevention research center. ..
  27. Translational Research in the Dystrophinopathies
    Kevin Flanigan; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  28. Eyestrain in Radiologists
    Elizabeth Krupinski; Fiscal Year: 2007
    ..Only by developing a better understanding of the nature of observer error, may we discover effective approaches to reducing the errors. [unreadable] [unreadable] [unreadable]..
  29. High-Throughput Evaluation of Breast Cancer Markers
    Richard Zangar; Fiscal Year: 2008
    ....
  30. Interactive Multimedia Simulation to Train Motivational Interviewing Skills
    Dale Olsen; Fiscal Year: 2007
    ..The proposed research will produce an innovative new training tool with the potential to increase learning and retention of MI skills among clinicians, thereby benefiting their patients. [unreadable] [unreadable] [unreadable]..
  31. Bioinformatics for Protein Microarrays
    Richard Zangar; Fiscal Year: 2009
    ....
  32. Prospective Investigation for Pulmonary Embolism Dx III
    Paul Stein; Fiscal Year: 2008
    ..abstract_text> ..
  33. Assessing an Adolescent Violence Screening Tool Longitudinally for Primary Care
    Eric Sigel; Fiscal Year: 2008
    ..By creating an easy to administer screening tool, health professionals will be able to recognize, and ultimately intervene before youth suffer the consequences of violence involvement. ..
  34. Development of Disease-Specific Drug Delivery Vehicles
    OMID FAROKHZAD; Fiscal Year: 2008
    ..Therefore, isolating disease-specific aptamers for use in targeted therapeutic and diagnostic applications has broad significance and may impact a myriad of important human diseases. ..
  35. Translational Research in the Dystrophinopathies
    Kevin Flanigan; Fiscal Year: 2007
    ..Although we do not propose to perform treatment trials at present, this proposed study will identify cohorts of patients who may be candidates for any future trials here or at other institutions. ..
  36. Eyestrain in Radiologists
    Elizabeth Krupinski; Fiscal Year: 2009
    ..Only by developing a better understanding of the nature of observer error, may we discover effective approaches to reducing the errors. ..
  37. Improving Heart Failure Risk Stratification in the ED
    Alan Storrow; Fiscal Year: 2008
    ..In collaboration with outcomes and effectiveness researchers, we plan to conduct further studies to test the efficacy of our risk model. ..
  38. Assessing an Adolescent Violence Screening Tool Longitudinally for Primary Care
    Eric Sigel; Fiscal Year: 2007
    ..By creating an easy to administer screening tool, health professionals will be able to recognize, and ultimately intervene before youth suffer the consequences of violence involvement. ..
  39. Eyestrain in Radiologists
    Elizabeth Krupinski; Fiscal Year: 2008
    ..Only by developing a better understanding of the nature of observer error, may we discover effective approaches to reducing the errors. ..
  40. MIPS XII Conference
    Elizabeth Krupinski; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  41. COMMUNITY CLINICAL ONCOLOGY PROGRAM
    Charles Loprinzi; Fiscal Year: 2008
    ..We will incorporate associated basic laboratory support, leading to scientifically rigorous translational research efforts. ..
  42. Translational Informatics for Global Health: An Argentina-Oregon Collaboration
    William Hersh; Fiscal Year: 2009
    ..This project aims to expand clinical and translational research in a large Argentine health system through informatics training and research. ..
  43. Rapid parallel salivary immunoassays on a disposable
    Paul Yager; Fiscal Year: 2005
    ..Finally, a versatile combined system will be designed and tested that will allow monitoring of samples by the two methods simultaneously. ..
  44. HOMOCYST(E)INE, OXIDATIVE STRESS, AND NITRIC OXIDE
    Joseph Loscalzo; Fiscal Year: 2001
    ..With these studies, we hope to gain insight into the molecular mechanisms of homocyst(e)ine-induced endothelial dysfunction and potential therapies for this common metabolic abnormality. ..
  45. A Microfluidic Diffusion Immunoassay
    Paul Yager; Fiscal Year: 2003
    ..abstract_text> ..
  46. PLATELET DERIVED REACTIVE OXYGEN SPECIES AND PLAQUE
    Joseph Loscalzo; Fiscal Year: 1999
    ....
  47. AMPHETAMINE ENHANCED STROKE RECOVERY--BURKE SRCI GROUP
    Larry Goldstein; Fiscal Year: 2000
    ..However the treatment duration will be increased to a total of 10 sessions. ..
  48. AMPHETAMINE ENHANCED STROKE RECOVERY--BURKE SRCI GROUP
    Larry Goldstein; Fiscal Year: 2002
    ..However the treatment duration will be increased to a total of 10 sessions. ..
  49. GENETIC EPIDEMIOLOGY OF ALZHEIMERS DISEASE IN HISPANICS
    Richard Mayeux; Fiscal Year: 2000
    ..The ultimate goal of this project is to chromosomally localize genes that may increase the risk of AD among the Caribbean Hispanic ethnic group. ..
  50. REGULATION OF XENOBIOTIC-METABOLIZING CYP3A
    Richard Zangar; Fiscal Year: 2000
    ....
  51. HOMOCYST(E)INE, OXIDATIVE STRESS, AND NITRIC OXIDE
    Joseph Loscalzo; Fiscal Year: 2000
    ..With these studies, the investigators hope to gain insight into the molecular mechanisms of homocyst(e)ine-induced endothelial dysfunction and potential therapies for this common metabolic abnormality. (End of Abstract) ..
  52. REGULATION OF XENOBIOTIC-METABOLIZING CYP3A
    Richard Zangar; Fiscal Year: 2002
    ....
  53. Translational Research in the Dystrophinopathies
    Kevin Flanigan; Fiscal Year: 2002
    ..abstract_text> ..
  54. GENETIC EPIDEMIOLOGY OF AGING IN A MULTIETHNIC COMMUNITY
    Richard Mayeux; Fiscal Year: 2000
    ....
  55. GPx-3, Vascular Oxidant Stress, and Thrombosis
    Joseph Loscalzo; Fiscal Year: 2003
    ..abstract_text> ..
  56. GENETIC EPIDEMIOLOGY OF ALZHEIMERS DISEASE IN HISPANICS
    Richard Mayeux; Fiscal Year: 2002
    ..The ultimate goal of this project is to chromosomally localize genes that may increase the risk of AD among the Caribbean Hispanic ethnic group. ..
  57. REGULATION OF XENOBIOTIC-METABOLIZING CYP3A
    Richard Zangar; Fiscal Year: 1999
    ....
  58. Horizontal Basal Cells in the Adult Olfactory Epithelium
    AMY CLEVENGER; Fiscal Year: 2005
    ..Better understanding of the basal cell populations within the OE will also allow us to take new directions in the prevention and treatment of olfactory dysfunction. ..
  59. PLATELET DERIVED REACTIVE OXYGEN SPECIES AND PLAQUE
    Joseph Loscalzo; Fiscal Year: 2000
    ....
  60. Improving Heart Failure Risk Stratification in the ED
    Alan Storrow; Fiscal Year: 2009
    ..In collaboration with outcomes and effectiveness researchers, we plan to conduct further studies to test the efficacy of our risk model. ..
  61. Center to Advance POC Diagnostics for Global Health
    Bernhard Weigl; Fiscal Year: 2008
    ....
  62. Improving Heart Failure Risk Stratification in the ED
    Alan B Storrow; Fiscal Year: 2010
    ..In collaboration with outcomes and effectiveness researchers, we plan to conduct further studies to test the efficacy of our risk model. ..
  63. HOMOCYST(E)INE, OXIDATIVE STRESS, AND NITRIC OXIDE
    Joseph Loscalzo; Fiscal Year: 1999
    ..With these studies, the investigators hope to gain insight into the molecular mechanisms of homocyst(e)ine-induced endothelial dysfunction and potential therapies for this common metabolic abnormality. (End of Abstract) ..
  64. Translational Research in the Dystrophinopathies
    Kevin Flanigan; Fiscal Year: 2009
    ..Although we do not propose to perform treatment trials at present, this proposed study will identify cohorts of patients who may be candidates for any future trials here or at other institutions. ..
  65. A PCT Sample Preparation System for Proteomic Research and Clinical Diagnostics
    Alexander Lazarev; Fiscal Year: 2008
    ....
  66. Center to Advance POC Diagnostics for Global Health
    Bernhard Weigl; Fiscal Year: 2008
    ..abstract_text> ..
  67. Research Training on Service Systems for Persons w/AIDS
    Oscar Grusky; Fiscal Year: 2008
    ..The program has close ties to the Center for HiV Identification, Prevention, and Treatment Services, an NIMH-sponsored prevention research center. ..
  68. Improving Heart Failure Risk Stratification in the ED
    Alan Storrow; Fiscal Year: 2009
    ..In collaboration with outcomes and effectiveness researchers, we plan to conduct further studies to test the efficacy of our risk model. ..
  69. Translational Research in the Dystrophinopathies
    Kevin Flanigan; Fiscal Year: 2009
    ..Although we do not propose to perform treatment trials at present, this proposed study will identify cohorts of patients who may be candidates for any future trials here or at other institutions. ..
  70. PLATELET DERIVED REACTIVE OXYGEN SPECIES AND PLAQUE
    Joseph Loscalzo; Fiscal Year: 2001
    ....
  71. New Methods for Evaluating Interobserver Agreement
    Michael Haber; Fiscal Year: 2005
    ..Existing and new agreement indices will be compared and linked. All the proposed methods will be applied to real data sets from the behavioral and biomedical sciences. ..
  72. Organizational Factors in the Early Detection of HIV
    Oscar Grusky; Fiscal Year: 2005
    ....
  73. New Methods for Evaluating Interobserver Agreement
    Michael Haber; Fiscal Year: 2004
    ..Existing and new agreement indices will be compared and linked. All the proposed methods will be applied to real data sets from the behavioral and biomedical sciences. ..
  74. GPx-3, Vascular Oxidant Stress, and Thrombosis
    Joseph Loscalzo; Fiscal Year: 2004
    ..abstract_text> ..
  75. A PCT Sample Preparation System for Proteomic Research and Clinical Diagnostics
    Feng Tao; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  76. Nucleic Acid Purification Using Pressure Cycling Technology
    Feng Tao; Fiscal Year: 2007
    ..If successful, this technology could be immediately employed in many fields of life sciences. [unreadable] [unreadable] [unreadable]..
  77. GPx-3, Vascular Oxidant Stress, and Thrombosis
    Joseph Loscalzo; Fiscal Year: 2005
    ..abstract_text> ..
  78. A Multiplex, Point-of-Care Test for Enteric Pathogens
    Bernhard Weigl; Fiscal Year: 2007
    ..abstract_text> ..
  79. GPx-3 and Peroxide Flux in the Endothelial Cell
    Joseph Loscalzo; Fiscal Year: 2007
    ..These studies should provide insight into the complex relationships among hydrogen peroxide flux, extracellular antioxidant potential, and cell signaling and oxidant stress in the endothelial cell. ..
  80. Tissue Homogenizaton by Pressure Cycling Technology
    Feng Tao; Fiscal Year: 2003
    ..The successful development of the PCT homogenization technology will benefit molecular based analytical procedures in genomics, medical, forensic, agricultural, pharmaceutical, veterinary and clinical applications ..
  81. Organizational Factors in the Early Detection of HIV
    Oscar Grusky; Fiscal Year: 2001
    ....
  82. Translational Research in the Dystrophinopathies
    Kevin Flanigan; Fiscal Year: 2008
    ..Although we do not propose to perform treatment trials at present, this proposed study will identify cohorts of patients who may be candidates for any future trials here or at other institutions. ..
  83. Organizational Factors in the Early Detection of HIV
    Oscar Grusky; Fiscal Year: 2002
    ....
  84. HOMOCYST(E)INE, OXIDATIVE STRESS, AND NITRIC OXIDE
    Joseph Loscalzo; Fiscal Year: 2002
    ..With these studies, we hope to gain insight into the molecular mechanisms of homocyst(e)ine-induced endothelial dysfunction and potential therapies for this common metabolic abnormality. ..
  85. GPx-3, Vascular Oxidant Stress, and Thrombosis
    Joseph Loscalzo; Fiscal Year: 2002
    ..abstract_text> ..
  86. BIOSTATISTICS DATA MANAGEMENT CENTER FOR ACRIN
    Constantine Gatsonis; Fiscal Year: 2007
    ..SITES: [unreadable] Center for Statistical Sciences, Brown University, Providence, RI [unreadable] Rhode Island Hospital, Providence, RI [unreadable] American College of Radiology, Philadelphia, PA [unreadable] [unreadable] [unreadable]..
  87. BIOSTATISTICS DATA MANAGEMENT CENTER FOR ACRIN
    Constantine Gatsonis; Fiscal Year: 2008
    ..10. To organize, facilitate and support outcomes and economics research in ACRIN studies. ..
  88. A Microfluidic Diffusion Immunoassay
    Paul Yager; Fiscal Year: 2004
    ..abstract_text> ..
  89. GPx-3, Vascular Oxidant Stress, and Thrombosis
    Joseph Loscalzo; Fiscal Year: 2006
    ..abstract_text> ..