general anesthesia

Summary

Top Publications

  1. ncbi Comparison of spinal and general anesthesia in lumbar laminectomy surgery: a case-controlled analysis of 400 patients
    Robert F McLain
    The Cleveland Clinic Spine Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Neurosurg Spine 2:17-22. 2005
  2. pmc TREK-1, a K+ channel involved in neuroprotection and general anesthesia
    C Heurteaux
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS, Institut Paul Hamel, Sophia Antipolis, Valbonne, France
    EMBO J 23:2684-95. 2004
  3. ncbi Predictors of hypotension after induction of general anesthesia
    David L Reich
    Department of Anesthesiology, Mount Sinai Medical Center, Box 1010, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Anesth Analg 101:622-8, table of contents. 2005
  4. ncbi General anesthesia activates BDNF-dependent neuroapoptosis in the developing rat brain
    Lucy X Lu
    Department of Anasthesiology, University of Virginia Health System, P O Box 800710, Charlottesville, 22908, USA
    Apoptosis 11:1603-15. 2006
  5. ncbi Single-injection paravertebral block before general anesthesia enhances analgesia after breast cancer surgery with and without associated lymph node biopsy
    Pekka M Kairaluoma
    Department of Anesthesia and Intensive Care Medicine, Helsinki University Hospital, PO Box 580, Helsinki, FIN 00029 HUS, Finland
    Anesth Analg 99:1837-43, table of contents. 2004
  6. doi Propofol induction reduces the capacity for neural information integration: implications for the mechanism of consciousness and general anesthesia
    UnCheol Lee
    Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI 48109 0048, USA
    Conscious Cogn 18:56-64. 2009
  7. pmc General anesthesia causes long-lasting disturbances in the ultrastructural properties of developing synapses in young rats
    N Lunardi
    Department of Anesthesiology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Neurotox Res 17:179-88. 2010
  8. ncbi Laryngotracheal topicalization with lidocaine before intubation decreases the incidence of coughing on emergence from general anesthesia
    Sean C Minogue
    Department of Anesthesia, Vancouver General Hospital and the University of British Columbia, Vancouver, BC, Canada
    Anesth Analg 99:1253-7, table of contents. 2004
  9. pmc Spine Surgery under general anesthesia may not increase the risk of Alzheimer's disease
    Chaoshun Zuo
    Duke University, Durham, NC, USA
    Dement Geriatr Cogn Disord 29:233-9. 2010
  10. ncbi Spinal versus general anesthesia for orthopedic surgery: anesthesia drug and supply costs
    Christopher Gonano
    Department of Anesthesiology and General Intensive Care, Medical University of Vienna, Austria
    Anesth Analg 102:524-9. 2006

Detail Information

Publications248 found, 100 shown here

  1. ncbi Comparison of spinal and general anesthesia in lumbar laminectomy surgery: a case-controlled analysis of 400 patients
    Robert F McLain
    The Cleveland Clinic Spine Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Neurosurg Spine 2:17-22. 2005
    ..Application of regional anesthetics is widely preferred for lower-extremity surgery, but general anesthesia is used almost exclusively in spine surgery, despite evidence that spinal anesthesia is as safe and may ..
  2. pmc TREK-1, a K+ channel involved in neuroprotection and general anesthesia
    C Heurteaux
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS, Institut Paul Hamel, Sophia Antipolis, Valbonne, France
    EMBO J 23:2684-95. 2004
    ..Trek1-/- mice are also resistant to anesthesia by volatile anesthetics. TREK-1 emerges as a potential innovative target for developing new therapeutic agents for neurology and anesthesiology...
  3. ncbi Predictors of hypotension after induction of general anesthesia
    David L Reich
    Department of Anesthesiology, Mount Sinai Medical Center, Box 1010, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Anesth Analg 101:622-8, table of contents. 2005
    Hypotension after induction of general anesthesia is a common event. In the current investigation, we sought to identify the predictors of clinically significant hypotension after the induction of general anesthesia...
  4. ncbi General anesthesia activates BDNF-dependent neuroapoptosis in the developing rat brain
    Lucy X Lu
    Department of Anasthesiology, University of Virginia Health System, P O Box 800710, Charlottesville, 22908, USA
    Apoptosis 11:1603-15. 2006
    ..beta-estradiol, a sex hormone that upregulates the protein levels of the activated Akt, protects against anesthesia-induced neuroapoptosis...
  5. ncbi Single-injection paravertebral block before general anesthesia enhances analgesia after breast cancer surgery with and without associated lymph node biopsy
    Pekka M Kairaluoma
    Department of Anesthesia and Intensive Care Medicine, Helsinki University Hospital, PO Box 580, Helsinki, FIN 00029 HUS, Finland
    Anesth Analg 99:1837-43, table of contents. 2004
    ..5 mg/kg) or saline before general anesthesia. The patient and attending investigators were blinded; the PVB or the sham block was performed behind a ..
  6. doi Propofol induction reduces the capacity for neural information integration: implications for the mechanism of consciousness and general anesthesia
    UnCheol Lee
    Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI 48109 0048, USA
    Conscious Cogn 18:56-64. 2009
    The cognitive unbinding paradigm suggests that the synthesis of neural information is attenuated by general anesthesia. Here, we analyzed the functional organization of brain activities in the conscious and anesthetized states, based on ..
  7. pmc General anesthesia causes long-lasting disturbances in the ultrastructural properties of developing synapses in young rats
    N Lunardi
    Department of Anesthesiology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Neurotox Res 17:179-88. 2010
    ..We believe that observed morphological disturbances of developing synapses may, at least in part, contribute to the learning and memory deficits that occur later in life after exposure of the immature brain to general anesthesia.
  8. ncbi Laryngotracheal topicalization with lidocaine before intubation decreases the incidence of coughing on emergence from general anesthesia
    Sean C Minogue
    Department of Anesthesia, Vancouver General Hospital and the University of British Columbia, Vancouver, BC, Canada
    Anesth Analg 99:1253-7, table of contents. 2004
    ..022). This study supports the use of endotracheal lidocaine before intubation in patients undergoing general anesthesia for surgery <2 h duration where coughing on emergence is undesirable.
  9. pmc Spine Surgery under general anesthesia may not increase the risk of Alzheimer's disease
    Chaoshun Zuo
    Duke University, Durham, NC, USA
    Dement Geriatr Cogn Disord 29:233-9. 2010
    Volatile anesthetics cause Alzheimer's disease (AD)-like neuropathology in animals. We determined whether spine surgery under general anesthesia and anesthetic choice contributed to AD development.
  10. ncbi Spinal versus general anesthesia for orthopedic surgery: anesthesia drug and supply costs
    Christopher Gonano
    Department of Anesthesiology and General Intensive Care, Medical University of Vienna, Austria
    Anesth Analg 102:524-9. 2006
    ..surgeries are common orthopedic interventions that can be performed with spinal anesthesia (SA) or general anesthesia (GA)...
  11. ncbi Effects of sevoflurane general anesthesia: immunological studies in mice
    N R Puig
    Institute of Immunology, School of Medicine, National University of Rosario, Santa Fe, Argentina
    Int Immunopharmacol 2:95-104. 2002
    ....
  12. ncbi Mechanisms of actions of inhaled anesthetics
    Jason A Campagna
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 348:2110-24. 2003
  13. ncbi Pain relief after arthroscopic shoulder surgery: a comparison of intraarticular analgesia, suprascapular nerve block, and interscalene brachial plexus block
    François J Singelyn
    Department of Anesthesiology, School of Medicine, Catholic University of Louvain, St Luc Hospital, Avenue Hippocrate 10 1821, B 1200 Brussels, Belgium
    Anesth Analg 99:589-92, table of contents. 2004
    ..25% bupivacaine. A control group was included for comparison. General anesthesia was administered to all patients. Patients were observed during the first 24 h...
  14. ncbi Prediction of difficult mask ventilation
    O Langeron
    Departement d Anesthesie Reanimation, Centre Hospitalo Universitaire Pitie Salpetriere, Universite Paris VI, Paris, France
    Anesthesiology 92:1229-36. 2000
    ..Because the incidence of difficult mask ventilation (DMV) and the factors associated with it are not well known, we undertook this prospective study...
  15. ncbi Difficult Airway Society guidelines for management of the unanticipated difficult intubation
    J J Henderson
    Anaesthetic Department, Gartnavel General Hospital, 1053 Great Western Road, Glasgow G12 0YN, UK
    Anaesthesia 59:675-94. 2004
    ..The flow-charts are simple, clear and definitive. They can be fully implemented only when the necessary equipment and training are available. The guidelines received overwhelming support from the membership of the DAS...
  16. doi Stress-induced cardiomyopathy following cephalosporin-induced anaphylactic shock during general anesthesia
    Eun Ha Suk
    Department of Anesthesiology and Pain Medicine, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea
    Can J Anaesth 56:432-6. 2009
    Anaphylaxis may be caused by various agents during general anesthesia. Sympathetic discharge may occur during anaphylaxis, which can trigger transient cardiomyopathy...
  17. ncbi Stress hormone changes in general anesthesia of long duration: isoflurane-nitrous oxide vs sevoflurane-nitrous oxide anesthesia
    Tomoki Nishiyama
    Department of Anesthesiology, Faculty of Medicine, The University of Tokyo, 113 8655 Tokyo, Japan
    J Clin Anesth 17:586-91. 2005
    There are few comparative studies of stress hormone changes during general anesthesia with long duration between isoflurane-nitrous oxide and sevoflurane-nitrous oxide anesthesia...
  18. ncbi Amyotrophic lateral sclerosis: the Midwestern surgical experience with the diaphragm pacing stimulation system shows that general anesthesia can be safely performed
    Raymond P Onders
    Department of Surgery, University Hospitals Case Medical Center, Detroit, MI, USA
    Am J Surg 197:386-90. 2009
    There is a paucity of literature concerning general anesthesia and surgery in patients with amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease)...
  19. ncbi Does yawning represent a transient arousal-shift during intravenous induction of general anesthesia?
    Yoshiko Kasuya
    Division of Anesthesia, Gifu Red Cross Hospital, Japan
    Anesth Analg 101:382-4, table of contents. 2005
    Although yawning occurs frequently during the IV induction of general anesthesia, the significance of this response remains unknown...
  20. ncbi Spinal-epidural anesthesia versus general anesthesia in the management of percutaneous nephrolithotripsy
    Serap Karacalar
    Department of Anesthesiology, Ondokuz Mayis University, Samsun, Turkey
    J Endourol 23:1591-7. 2009
    To compare the efficacy between combined spinal-epidural block and general anesthesia in patients undergoing percutaneous nephrolithotripsy (PNL).
  21. ncbi Epidural plus general anesthesia vs general anesthesia alone for elective aortic surgery: effects on gastric electrical activity and serum gastrin secretion
    L Lombardo
    Department of Gastroenterology, Mauriziano U I Hospital, Turin, Italy
    Minerva Anestesiol 75:109-15. 2009
    ..of this study was to evaluate differences in electrogastrographic activity and serum gastrin secretion in patients subjected to general anesthesia (GA) vs blended anesthesia (BA = GA plus epidural analgesia) for abdominal aortic surgery.
  22. ncbi Regional or general anesthesia for carotid endarterectomy? Evidence from published prospective and retrospective studies
    Joanne Guay
    Department of Anesthesia, Maisonneuve Rosemont Hospital, University of Montreal, Montreal, Quebec, Canada
    J Cardiothorac Vasc Anesth 21:127-32. 2007
    The aim of this study was to compare outcomes of patients undergoing carotid endarterectomy under regional or general anesthesia for any new neurologic impairment, stroke, stroke and/or death, death, and myocardial infarction.
  23. ncbi The effects of valerian on the time course of emergence from general anesthesia in Sprague-Dawley rats (Rattus norvegicus)
    Robert L Chaplin
    U S Air Force Academy, Colorado, USA
    AANA J 75:431-5. 2007
    ..These data demonstrate the need for continued research concerning the effects of herbals and their potential for interaction with anesthetics...
  24. pmc A combination therapy of ethanol injection and radiofrequency ablation under general anesthesia for the treatment of hepatocellular carcinoma
    Kazutaka Kurokohchi
    Department of Gastroenterology, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    World J Gastroenterol 14:2037-43. 2008
    ..the effects of laparoscopic ethanol injection and radiofrequency ablation (L-EI-RFA), thoracoscopic (T-EI-RFA) and open-surgery assisted EI-RFA (O-EI-RFA) under general anesthesia for the treatment of hepatocellular carcinoma (HCC).
  25. ncbi The effects of pneumoperitoneum on respiratory mechanics during general anesthesia for bariatric surgery
    Abdelazeem Ali El-Dawlatly
    Department of Anaesthesia, College of Medicine, King Saud University, King Khalid University Hospital, Riyadh, Saudia Arabia
    Obes Surg 14:212-5. 2004
    ..The effects of pneumoperitoneum (PPM) on respiratory mechanics during bariatric surgery were investigated...
  26. ncbi Prevention of atelectasis in morbidly obese patients during general anesthesia and paralysis: a computerized tomography study
    Henrik Reinius
    Department of Anesthesia and Intensive Care, University Hospital, Uppsala, Sweden
    Anesthesiology 111:979-87. 2009
    ..This study analyzed the effect of general anesthesia and three different ventilatory strategies to reduce the amount of atelectasis and improve respiratory ..
  27. ncbi Comparison of three anesthetic techniques for off-pump coronary artery bypass grafting: general anesthesia, combined general and high thoracic epidural anesthesia, or high thoracic epidural anesthesia alone
    Paul Kessler
    Department of Anesthesiology and Intensive Care Medicine, Orthopedic University Hospital, Friedrichsheim Foundation, Frankfurt, Germany
    J Cardiothorac Vasc Anesth 19:32-9. 2005
    This study compared general anesthesia (GA), combined GA plus thoracic epidural anesthesia (TEA), and TEA alone in patients scheduled for off-pump coronary artery bypass grafting.
  28. ncbi Takotsubo cardiomyopathy after general anesthesia for eye surgery
    Doron Gavish
    Department of Anesthesia, The Edith Wolfson Medical Center, Holon, Israel
    Anesthesiology 105:621-3. 2006
  29. ncbi Frequency of anesthesia-related complications in children with Down syndrome under general anesthesia for noncardiac procedures
    Lawrence M Borland
    Department of Pediatric Anesthesiology, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Paediatr Anaesth 14:733-8. 2004
    ..Craniofacial and cardiac anomalies of Down syndrome (DS; trisomy 21) would seem to place these patients at higher risk of anesthesia-related complications (ARCs), but to date no comprehensive large-scale study has quantified this risk...
  30. ncbi Minimally invasive parathyroidectomy using cervical block: reasons for conversion to general anesthesia
    Tobias Carling
    Yale University School of Medicine, New Haven, CT 06510, USA
    Arch Surg 141:401-4; discussion 404. 2006
    We investigated the frequency and reasons for conversion from cervical block anesthesia to general anesthesia (GA) in patients undergoing minimally invasive parathyroidectomy for primary hyperparathyroidism.
  31. ncbi A prospective randomized study comparing perioperative outcome variables after epidural or general anesthesia for lumbar disc surgery
    Cengiz Bekir Demirel
    Department of Anesthesiology, University of Zonguldak Karaelmas, Faculty of Medicine, Zonguldak, Turkey
    J Neurosurg Anesthesiol 15:185-92. 2003
    ..The aim of this study was to assess the superiority of general anesthesia or epidural anesthesia techniques in lumbar laminectomy and discectomy...
  32. ncbi Positron emission tomography study of regional cerebral metabolism during general anesthesia with xenon in humans
    Steffen Rex
    Department of Anesthesiology, University Hospital, RWTH Aachen, Aachen, Germany
    Anesthesiology 105:936-43. 2006
    ..Therefore, the authors hypothesized that xenon, similar to ketamine and nitrous oxide, increases global and regional cerebral metabolism in humans...
  33. ncbi Suppression of cough during emergence from general anesthesia: laryngotracheal lidocaine through a modified endotracheal tube
    C A Diachun
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305 5640, USA
    J Clin Anesth 13:447-51. 2001
    To ascertain if coughing during emergence from general anesthesia can be suppressed with a modified endotracheal tube.
  34. ncbi Prevention of atelectasis formation during induction of general anesthesia
    Marco Rusca
    Departments of Anesthesiology, University Hospital, Lausanne, Switzerland
    Anesth Analg 97:1835-9. 2003
    b>General anesthesia promotes atelectasis formation, which is augmented by administration of large oxygen concentrations...
  35. ncbi Medicaid costs associated with the hospitalization of young children for restorative dental treatment under general anesthesia
    M J Kanellis
    Department of Pediatric Dentistry, University of Iowa, Iowa City 52242, USA
    J Public Health Dent 60:28-32. 2000
    This paper examines the cost to the Iowa Medicaid program of hospitalizing young children for restorative dental care under general anesthesia, and describes the dental services received in this setting.
  36. ncbi The memory effects of general anesthesia persist for weeks in young and aged rats
    Deborah J Culley
    Department of Anesthesia, Harvard Medical School, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Anesth Analg 96:1004-9, table of contents. 2003
    ..We tested the hypothesis that general anesthesia contributes to this cognitive impairment...
  37. ncbi Preoperative combined with intraoperative skin-surface warming avoids hypothermia caused by general anesthesia and surgery
    Simone Maria D Angelo Vanni
    Department of Anesthesiology, School of Medicine of the University of São Paulo State, Botucatu, Sao Paulo, Brazil
    J Clin Anesth 15:119-25. 2003
    ....
  38. ncbi Regional anesthesia is a good alternative to general anesthesia in pediatric surgery: Experience in 1,554 children
    Sema Uguralp
    Departments of Pediatric Surgery and Anesthesiology, Turgut Ozal Medical Center, Inonu University, Faculty of Medicine, Malatya, Turkey
    J Pediatr Surg 37:610-3. 2002
    ..and spinal blocks are modern and safe techniques, in many centers children still are operated on under general anesthesia (GA), or the blocks are used for postoperative analgesia after GA in infraumbilical operations...
  39. ncbi The effects of intracuff lidocaine on endotracheal-tube-induced emergence phenomena after general anesthesia
    C Fagan
    Department of Anesthesia, St James s Hospital and St Vincent s Hospital, Dublin, Ireland
    Anesth Analg 91:201-5. 2000
    Coughing during emergence from general anesthesia is a common clinical problem...
  40. ncbi Mitochondrial perturbations and oxidant stress in lymphocytes from patients undergoing surgery and general anesthesia
    G Delogu
    Institute of Anesthesia and Intensive Care, Policlinico Umberto I, La Sapienza University, 00161 Rome, Italy
    Arch Surg 136:1190-6. 2001
    ..that a profound suppression of immune function transiently occurs in patients who undergo surgery under general anesthesia. The decline in the absolute counts of peripheral blood lymphocytes constitutes a major factor accounting ..
  41. ncbi Prevention of atelectasis formation during the induction of general anesthesia in morbidly obese patients
    Marta Coussa
    Department of Anesthesiology, University Hospital, Lausanne, Switzerland
    Anesth Analg 98:1491-5, table of contents. 2004
    Atelectasis caused by general anesthesia is increased in morbidly obese patients...
  42. doi Ultrasound-guided axillary brachial plexus block with 20 milliliters local anesthetic mixture versus general anesthesia for upper limb trauma surgery: an observer-blinded, prospective, randomized, controlled trial
    Brian D O'Donnell
    Department of Anesthesia, Cork University Hospital, Wilton Rd, Cork, Ireland
    Anesth Analg 109:279-83. 2009
    We performed a randomized, controlled trial comparing low-dose ultrasound-guided axillary block with general anesthesia evaluating anesthetic and perioperative analgesic outcomes.
  43. ncbi Safety of same day discharge in patients undergoing sutureless thyroidectomy: a comparison of local and general anesthesia
    William B Inabnet
    Division of Gastrointestinal and Endocrine Surgery, Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, New York, USA
    Thyroid 18:57-61. 2008
    ..The aim of this study was to assess the safety and efficacy of the electrothermal bipolar vessel sealing system in permitting ambulatory thyroid surgery under local anesthesia...
  44. doi The ability of pleth variability index to predict the hemodynamic effects of positive end-expiratory pressure in mechanically ventilated patients under general anesthesia
    Olivier Desebbe
    Hospices Civils de Lyon, Department of Anesthesiology and Intensive Care, Louis Pradel Hospital, Claude Bernard Lyon 1 University, INSERM ERI 22, Lyon, France
    Anesth Analg 110:792-8. 2010
    ..PVI can predict fluid responsiveness noninvasively in mechanically ventilated patients during general anesthesia. We hypothesized that PVI could predict the hemodynamic effects of 10 cm H2O positive end-expiratory ..
  45. doi Practical use of the raw electroencephalogram waveform during general anesthesia: the art and science
    Cambell Bennett
    Waikato Clinical School, Waikato Hospital, Hamilton, New Zealand
    Anesth Analg 109:539-50. 2009
    ..qEEG) monitors are often used to estimate depth of anesthesia and intraoperative recall during general anesthesia. As with any monitor, the processed numerical output is often misleading and has to be interpreted within a ..
  46. ncbi Preoxygenation is more effective in the 25 degrees head-up position than in the supine position in severely obese patients: a randomized controlled study
    Benjamin J Dixon
    Australian Center for Obesity Research and Education, Monash University, Alfred Hospital, Melbourne 3181, Victoria, Australia
    Anesthesiology 102:1110-5; discussion 5A. 2005
    ..The authors explored the hypothesis that preoxygenation in the 25 degrees head-up position allows a greater safety margin for induction of anesthesia than the supine position...
  47. ncbi Dental treatment under general anesthesia in healthy and medically compromised developmentally disabled children: a comparative study
    Juan Pablo Loyola-Rodriguez
    San Luis Potosi University, San Luis Potosi, SLP, Mexico
    J Clin Pediatr Dent 34:177-82. 2009
    To compare the type, number of procedures and working time of dental treatment provided under dental general anesthesia (DGA) in healthy and medically compromised/developmentally disabled children (MCDD children).
  48. doi The effect of forced-air warming during arthroscopic shoulder surgery with general anesthesia
    Hyung Seok Yoo
    Department of Anesthesiology and Pain Medicine, College of Medicine, Kyung Hee University, Seoul, South Korea
    Arthroscopy 25:510-4. 2009
    ..In both groups irrigation fluid at room temperature (22 degrees C) was used...
  49. ncbi Intraoperative myocardial ischemia in peripheral vascular surgery: general anesthesia vs combined sciatic and femoral nerve blocks
    Alexandre Yazigi
    Department of Anesthesia and Intensive Care, Hotel Dieu de France Hospital, Beirut, Lebanon
    J Clin Anesth 17:499-503. 2005
    The aim of this study was to compare the frequency of intraoperative myocardial ischemia in lower extremity vascular surgery with general anesthesia vs regional anesthesia via combined sciatic and femoral nerve blocks.
  50. ncbi Changes of bispectral index during recovery from general anesthesia with 2% propofol and remifentanil in children
    Hye Jin Park
    Department of Anesthesiology, College of Medicine, Eulji University, Korea
    Paediatr Anaesth 17:353-7. 2007
    ..The aim of this study was to investigate the relationship between BIS index and predicted plasma concentration of propofol delivered by target controlled infusion (TCI) during emergence in children...
  51. ncbi Local/cervical block anesthesia versus general anesthesia for minimally invasive parathyroidectomy: what are the advantages?
    Michael J Black
    Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison, WI, USA
    Ann Surg Oncol 14:744-9. 2007
    ..Advantages of LA versus general anesthesia (GA) for these focused procedures have not been clearly demonstrated.
  52. ncbi Parental presence during induction enhances the effect of oral midazolam on emergence behavior of children undergoing general anesthesia
    Y C P Arai
    Multidisciplinary Pain Center, Aichi Medical University, School of Medicine, Aichi, Japan
    Acta Anaesthesiol Scand 51:858-61. 2007
    ..The aim of the present study was to test if a combination of mother presence and midazolam premedication is effective for improving emergence condition in children undergoing general anesthesia.
  53. ncbi 532 nm pulsed potassium-titanyl-phosphate laser treatment of laryngeal papillomatosis under general anesthesia
    James A Burns
    Department of Surgery, Harvard Medical School, Center for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Laryngoscope 117:1500-4. 2007
    ..This investigation provides the first report of the pulsed-KTP laser during microlaryngoscopy under general anesthesia.
  54. ncbi Intraarticular lesions in primary frozen shoulder after manipulation under general anesthesia
    Markus Loew
    Department of Shoulder and Elbow Surgery, University Hospital for Orthopaedic Surgery, Heidelberg, Germany
    J Shoulder Elbow Surg 14:16-21. 2005
    The aim of this study was to find intraarticular lesions after manipulation under general anesthesia in patients with primary frozen shoulder...
  55. ncbi The efficacy of caudal morphine or bupivacaine combined with general anesthesia on postoperative pain and neuroendocrine stress response in children
    Erkan Teyin
    Department of Anaesthesiology and Reanimation, Ege University Hospital, Bornova, Izmir, Turkey
    Paediatr Anaesth 16:290-6. 2006
    ....
  56. ncbi The clinical assessment of Glidescope in orotracheal intubation under general anesthesia
    F S Xue
    Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People s Republic of China
    Minerva Anestesiol 73:451-7. 2007
    ....
  57. ncbi Temperature control and recovery of bowel function after laparoscopic or laparotomic colorectal surgery in patients receiving combined epidural/general anesthesia and postoperative epidural analgesia
    Giorgio Danelli
    Department of Anesthesiology, Vita Salute University of Milano, IRCCS H S Raffaele, Milano, Italy
    Anesth Analg 95:467-71, table of contents. 2002
    ..surgery on temperature control in 44 patients undergoing colorectal surgery during a combined epidural/general anesthesia. A thoracic epidural block up to T4 was induced with 6-10 mL of 0...
  58. doi Loss of effective connectivity during general anesthesia
    Michael T Alkire
    University of California, Irvine, California, USA
    Int Anesthesiol Clin 46:55-73. 2008
  59. ncbi The effectiveness of 4% intracuff lidocaine in reducing coughing during emergence from general anesthesia in smokers undergoing procedures lasting less than 1.5 hours
    Laura E Wetzel
    University of Michigan Flint Hurley Medical Center Anesthesia Program, USA
    AANA J 76:105-8. 2008
    ..This study did not show a correlation between use of intracuff lidocaine and a decrease in emergence coughing in procedures lasting less than 1.5 hours in patients who smoke...
  60. doi The effect of ketamine and nitrous oxide on the human pupillary light reflex during general anesthesia
    Helge Eilers
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0648, USA
    Auton Neurosci 152:108-14. 2010
    ..To study this question, sixteen patients received general anesthesia with desflurane, fentanyl, and muscular relaxation with rocuronium...
  61. ncbi Optimal oxygen concentration during induction of general anesthesia
    Lennart Edmark
    Department of Anesthesiology and Intensive Care, Central Hospital, Vasteras, and Research Associate, Department of Medical Sciences, Clinical Physiology, University Hospital, Uppsala, Sweden
    Anesthesiology 98:28-33. 2003
    ..The use of 100% oxygen during induction of anesthesia may produce atelectasis. The authors investigated how different oxygen concentrations affect the formation of atelectasis and the fall in arterial oxygen saturation during apnea...
  62. ncbi Lymphocyte apoptosis after major abdominal surgery is not influenced by anesthetic technique: a comparative study of general anesthesia versus combined general and epidural analgesia
    Artemisia Papadima
    Laboratory of Surgical Research, 1st Department of Propaedeutic Surgery, Hippokrateio Hospital, University of Athens, 11527 Athens, Greece
    J Clin Anesth 21:414-21. 2009
    To examine the influence of abdominal colectomy with combined general anesthesia and epidural analgesia versus general anesthesia on apoptosis of circulating lymphocytes.
  63. ncbi Comprehensive dental treatment under general anesthesia in healthy and disabled children
    Pei Ying Lee
    Department of Pediatric Dentistry, Chang Gung Memorial Hospital at Taipei, Chang Gung University College of Medicine, Taoyuan, Taiwan
    Chang Gung Med J 32:636-42. 2009
    Differences in dental treatment under general anesthesia (GA) in healthy and disabled children are rarely reported...
  64. doi Combined general/epidural anesthesia (ropivacaine 0.375%) versus general anesthesia for upper abdominal surgery
    Yuhong Li
    Department of Anesthesiology, First Affiliated Hospital, School of Medicine, Zhejiang University, People s Republic of China
    Anesth Analg 106:1562-5, table of contents. 2008
    We designed this study to investigate the effect of 0.375% ropivacaine on stress hormone responses and anesthetic requirements in combined epidural/general anesthesia for nephrectomy.
  65. ncbi The influence of inspired oxygen fraction and end-tidal carbon dioxide on post-cross-clamp cerebral oxygenation during carotid endarterectomy under general anesthesia
    Paul Picton
    Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Anesth Analg 110:581-7. 2010
    ..We performed this study to determine the influence of Fio(2) and end-tidal carbon dioxide (Petco(2)) on rSO(2) in patients undergoing CEA with general anesthesia during carotid cross-clamping.
  66. ncbi [General anesthesia with remifentanil for a patient having sinoatrial block and constrictive pulmonary disorder]
    Yumiko Nishio
    Department of Anesthesiology, University of Occupational and Environmental Health, Kitakyushu 807 8555
    Masui 57:1002-4. 2008
    ..Respiratory dysfunction was not seen in the postoperative course. Our case suggests that remifentanil may be a suitable analgesic for patients with cardiac conduction abnormalities...
  67. ncbi Carotid Artery Stump Pressure (CASP) in 1135 consecutive endarterectomies under general anesthesia: an old method that survived the test of times
    T Jacob
    Division of Vascular Surgery, Maimonides Medical Center, Brooklyn, NY 11219, USA
    J Cardiovasc Surg (Torino) 48:677-81. 2007
    ..Herein, we attempt to demonstrate that CASP is a reliable test that does not need to be replaced by more sophisticated and expensive techniques...
  68. ncbi The relationship between current intensity for nerve stimulation and success of peripheral nerve blocks performed in pediatric patients under general anesthesia
    Harshad Gurnaney
    Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4399, USA
    Anesth Analg 105:1605-9, table of contents. 2007
    ..the relationship between the lowest current amperage used to obtain a motor response, the success rate and the incidence of neurological complications with peripheral nerve blocks (PNB) in pediatric patients under general anesthesia.
  69. doi Laparoscopic cholecystectomy under spinal versus general anesthesia: a prospective, randomized study
    Samer S Bessa
    Department of General Surgery, University of Alexandria, Alexandria, Egypt
    J Laparoendosc Adv Surg Tech A 20:515-20. 2010
    For laparoscopic cholecystectomy (LC), the use of spinal anesthesia may offer several advantages over general anesthesia. The aim of this prospective, randomized study was to compare the surgical outcome of LC performed under general ..
  70. ncbi Nerve stimulator guided pudendal nerve block versus general anesthesia for hemorrhoidectomy
    Zoher Naja
    Department of Anesthesia and Pain Medicine, Makassed General Hospital, P O Box 11 6301 Riad El Solh 11072210, Beirut, Lebanon
    Can J Anaesth 53:579-85. 2006
    ..that patients receiving a nerve stimulator guided pudendal nerve block for hemorrhoidectomy would experience more effective and prolonged postoperative analgesia and shorter hospital stay compared to patients receiving general anesthesia.
  71. ncbi Pharmacokinetics and pharmacodynamics of propofol infusions during general anesthesia
    A Shafer
    Department of Anesthesia, Stanford University Medical Center, California
    Anesthesiology 69:348-56. 1988
    ..38-0.43 microgram/ml (EC50). This clinical study demonstrates the feasibility of performing pharmacokinetic and pharmacodynamic analyses when complex infusion and bolus regimens are used for administering iv anesthetics...
  72. ncbi [Hyperventilation syndrome before induction of and after awakening from general anesthesia]
    Ju Mizuno
    Department of Anesthesiology, Teikyo University School of Medicine, Tokyo
    Masui 58:768-71. 2009
    ..We experienced hyperventilation syndrome before induction of and after awakening from general anesthesia. A 53-year-old woman with no central nervous and psychiatric disease was scheduled for left total hip ..
  73. ncbi Paravertebral blocks provide superior same-day recovery over general anesthesia for patients undergoing inguinal hernia repair
    Admir Hadzic
    The Department of Anesthesiology, St Luke s Roosevelt Hospital Center, College of Physicians and Surgeons of Columbia University, New York, New York 10025, USA
    Anesth Analg 102:1076-81. 2006
    Inguinal herniorrhaphy is commonly performed on an outpatient basis under nerve blocks or local or general anesthesia (GA)...
  74. pmc Simultaneous electroencephalography and functional magnetic resonance imaging of general anesthesia
    Patrick L Purdon
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Ann N Y Acad Sci 1157:61-70. 2009
    ..have become important tools for studying how anesthetic drugs act in the human brain to induce the state of general anesthesia. To date, no investigation has combined functional MRI with EEG to study general anesthesia...
  75. ncbi Postoperative outcome among elderly patients after general anesthesia
    Y Kojima
    Department of Anesthesiology, Suwa Red Cross Hospital, and Department of Anesthesiology and Reanimatology, Shinshu University School of Medicine, Nagano, Japan
    Acta Anaesthesiol Scand 50:19-25. 2006
    ..The aim of this study was to identify preoperative risk factors for decreased 1- to 5-year survival rates and to compare the survival rates of stratified risk groups with those of the sex- and age-matched general population...
  76. ncbi Safety of general anesthesia for lumbar puncture and bone marrow aspirate/biopsy in pediatric oncology patients
    Clarice F Meneses
    Pediatric Oncology Unit daggerAnesthesiology, Perioperative Medicine Unit, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Brazil
    J Pediatr Hematol Oncol 31:465-70. 2009
    ..This study evaluated the frequency and severity of complications of bone marrow aspiration biopsy and lumbar puncture/intrathecal chemotherapy under general anesthesia.
  77. ncbi Preoperative oral dextromethorphan attenuated tourniquet-induced arterial blood pressure and heart rate increases in knee cruciate ligament reconstruction patients under general anesthesia
    Soichiro Yamashita
    Departments of Anesthesia and Critical Care Medicine, Iwaki Kyoritsu General Hospital, Iwaki, Fukushima, Japan
    Anesth Analg 98:994-8, table of contents. 2004
    ..and heart rate changes during tourniquet inflation in knee cruciate ligament reconstruction patients under general anesthesia. Patients in the DM group (n = 38) received oral DM 30 mg, and patients in the control group (n = 38) ..
  78. doi The effect of low-dose remifentanil on responses to the endotracheal tube during emergence from general anesthesia
    Marie T Aouad
    Department of Anesthesiology, American University of Beirut Medical Center, Beirut, Lebanon
    Anesth Analg 108:1157-60. 2009
    Emergence from general anesthesia can be associated with coughing, agitation, and hemodynamic disturbances. Remifentanil may attenuate these responses.
  79. doi Lateral antebrachial cutaneous neuropathy as a result of positioning while under general anesthesia
    Amy Judge
    Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7010, USA
    Anesth Analg 110:122-4. 2010
    ..We present a case of lateral antebrachial cutaneous neuropathy after prolonged general anesthesia for left medial meniscal transplant and microfracture surgery...
  80. pmc Intrathecal morphine plus general anesthesia in cardiac surgery: effects on pulmonary function, postoperative analgesia, and plasma morphine concentration
    Luciana Moraes dos Santos
    Department of Anesthesia, Heart Institute, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Clinics (Sao Paulo) 64:279-85. 2009
    ..To evaluate the effects of intrathecal morphine on pulmonary function, analgesia, and morphine plasma concentrations after cardiac surgery...
  81. ncbi The recovery of cognitive function after general anesthesia in elderly patients: a comparison of desflurane and sevoflurane
    X Chen
    Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9068, USA
    Anesth Analg 93:1489-94, table of contents. 2001
    We evaluated the cognitive recovery profiles in elderly patients after general anesthesia with desflurane or sevoflurane...
  82. ncbi General anesthesia for surgery influences melatonin and cortisol levels
    Edward Ram
    Department of General Surgery, Nazareth Hospital EMMS, Nazareth, Israel
    World J Surg 29:826-9. 2005
    The purpose of this study was to investigate the effect of general anesthesia and surgery on melatonin production, and to assess the relationship between melatonin secretion and cortisol levels...
  83. pmc Intranasal sufentanil/midazolam versus ketamine/midazolam for analgesia/sedation in the pediatric population prior to undergoing multiple dental extractions under general anesthesia: a prospective, double-blind, randomized comparison
    J A Roelofse
    Department of Anesthesiology, Faculty of Dentistry, University of Stellenbosch
    Anesth Prog 51:114-21. 2004
    ..Effective postoperative analgesia for multiple dental extractions was provided. The intranasal administration of drugs for sedation and analgesia has some promising features in preschool children undergoing multiple dental extractions...
  84. ncbi Preoperative stellate ganglion blockade prevents tourniquet-induced hypertension during general anesthesia
    Y C P Arai
    Department of Anesthesiology, Ehime Rosai Hospital, Ehime, Japan
    Acta Anaesthesiol Scand 48:613-8. 2004
    ..The present study was performed to investigate the effects of stellate ganglion block (SGB) on arterial pressure and heart rate during prolonged tourniquet use under general anesthesia.
  85. ncbi Hemodynamic effect of propofol in enalapril-treated hypertensive patients during induction of general anesthesia
    Małgorzata Malinowska-Zaprzałka
    Emergency Department, Medical University of Białystok, Waszyngtona 15A, PL 15 274 Białystok, Poland
    Pharmacol Rep 57:675-8. 2005
    ..converting enzyme inhibitor (ACE-I) treated hypertensive patients are well known to be at risk during general anesthesia, because of hypotension that can occur...
  86. ncbi Cerebral oxygenation in the beach chair position before and during general anesthesia
    K Tange
    Department of Anesthesiology, Wakayama Medical University, Wakayama, Wakayama 641 0012, Japan
    Minerva Anestesiol 76:485-90. 2010
    ..The current study was designed to evaluate whether the beach chair position before and during general anesthesia differentially induces changes in cerebral oxygenation as determined by near-infrared spectroscopy (NIRS) in ..
  87. ncbi Near-death experience in a boy undergoing uneventful elective surgery under general anesthesia
    Ursula Lopez
    Division of Anesthesiology, University Hospital of Geneva, Geneva, Switzerland
    Paediatr Anaesth 16:85-8. 2006
    ..We report on an episode of NDE that occurred in a 12-year-old boy who underwent a general anesthesia for an elective uncomplicated surgery...
  88. ncbi A comparison of emergence delirium scales following general anesthesia in children
    Samira A Bajwa
    Department of Paediatric Anaesthesia, Women s and Children s Hospital, Adelaide, SA, Australia
    Paediatr Anaesth 20:704-11. 2010
    ..Emergence delirium (ED) is of increasing interest since the introduction of short-acting volatiles such as sevoflurane...
  89. ncbi Epidural anesthesia for coronary artery bypass surgery compared with general anesthesia alone does not reduce biochemical markers of myocardial damage
    Michael J Barrington
    Department of Anaesthesia, St Vincent s Hospital, Melbourne, PO Box 2900, Fitzroy, Victoria 3065, Australia
    Anesth Analg 100:921-8. 2005
    ..One-hundred-twenty patients were randomized to a general anesthesia (GA) group or a GA plus HTEA group. The GA group received fentanyl (7-15 microg/kg) and a morphine infusion...
  90. pmc Thermoregulation: physiological and clinical considerations during sedation and general anesthesia
    Marcos Diaz
    Anesth Prog 57:25-32; quiz 33-4. 2010
    Mild hypothermia is common during deep sedation or general anesthesia and is frequently associated with patient discomfort and shivering...
  91. ncbi Recurrence of early childhood caries after comprehensive treatment with general anesthesia and follow-up
    Tyger Foster
    Women and Children s Hospital of Buffalo, University at Buffalo School of Dental Medicine, Buffalo, NY, USA
    J Dent Child (Chic) 73:25-30. 2006
    Children diagnosed with early childhood caries (ECC) receive comprehensive treatment using general anesthesia at the Women and Children's Hospital of Buffalo...
  92. ncbi Water as a complex system: its role in ligand diffusion, general anesthesia, and sleep
    Lemont B Kier
    Center for the Study of Biological Complexity, Virginia Commonwealth University, VCU Life Sciences, Suite 111, 1000 West Cary Street, P O Box 842030, Richmond, VA 23284 2030, USA
    Chem Biodivers 4:2473-9. 2007
    ..In view of the similarities between this anesthetic state and sleep, this mechanism is proposed to be operative for the sleep/wake states. Based on this mechanism and other factors, nitrogen (N2) is proposed as an exogenous sleep factor...
  93. doi Adie syndrome associated with general anesthesia
    Mizuka Kobayashi
    Can J Anaesth 55:130-1. 2008
  94. doi Remifentanil for cesarean section under general anesthesia: effects on maternal stress hormone secretion and neonatal well-being: a randomized trial
    G Draisci
    Istituto di Anestesiologia e Rianimazione, Dipartimento di Emergenza e Accettazione Istituto di Chimica Clinica, Universita Cattolica del Sacro Cuore, Istituto Superiore di Sanita, Rome, Italy
    Int J Obstet Anesth 17:130-6. 2008
    Remifentanil may attenuate maternal hemodynamic response during cesarean section under general anesthesia, but could cause transient but significant neonatal depression...
  95. ncbi Postoperative cognitive dysfunction in adult and elderly patients--general anesthesia vs subarachnoid or epidural analgesia
    Hisham M F Anwer
    Faculty of Medicine, Alexandria University
    Middle East J Anesthesiol 18:1123-38. 2006
    This study compared the effect of general anesthesia or regional vertebral analgesia (subarachnoid or epidural) on postoperative cognitive function in 60 young adult (group A) and 60 elderly (group E) patients undergoing orthopedic and ..
  96. ncbi A clinical assessment of the Glidescope videolaryngoscope in nasotracheal intubation with general anesthesia
    Fushan Xue
    Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100041, People s Republic of China
    J Clin Anesth 18:611-5. 2006
    ....
  97. ncbi Relatively light general anesthesia is more effective than fluid expansion in reducing the severity of epinephrine-induced hypotension during functional endoscopic sinus surgery
    Wei yan Li
    Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, China
    Chin Med J (Engl) 120:1299-302. 2007
    ..infiltration of the nasal mucosa causes hypotension during functional endoscopic sinus surgery (FESS) under general anesthesia. A prospective randomized-controlled study was designed to determine whether relatively light general ..
  98. ncbi Uncomplicated general anesthesia in the elderly results in cognitive decline: does cognitive decline predict morbidity and mortality?
    M C Lewis
    Miller School of Medicine, University of Miami, Miami, FL 33101, USA
    Med Hypotheses 68:484-92. 2007
    ..This paper examines the proposition that general anesthesia causes harm to elderly patients with its impact being felt long after the anesthetic agents are cleared from ..
  99. ncbi Induced hypotension with epidural/general anesthesia reduces transfusion in radical prostate surgery
    Paul J O'Connor
    Department of Anesthesiology and Pain Medicine, University of Alberta, Edmonton, Alberta, Canada
    Can J Anaesth 53:873-80. 2006
    ..We investigated the efficacy of deliberate hypotension using combined epidural/general anesthesia in reducing allogeneic transfusion requirements in patients undergoing radical prostatectomy.
  100. doi A prospective randomized trial comparing the technique of spinal and general anesthesia for lumbar disk surgery: a study of 100 cases
    Seyed Hossein Sadrolsadat
    Sina Hospital, Medical Sciences University of Tehran, Tehran, Iran
    Surg Neurol 71:60-5; discussion 65. 2009
    b>General anesthesia and regional anesthesia have both been shown to be suitable techniques for patients undergoing lower thoracic and lumbar spine surgery; however, GA is the most frequently used method...
  101. ncbi Combined spinal and general anesthesia attenuates liver metastasis by preserving TH1/TH2 cytokine balance
    Hiroki Wada
    Department of Anesthesiology, National Defense Medical College, Namiki, Tokorozawa, Japan
    Anesthesiology 106:499-506. 2007
    ..lessens infection by attenuating perioperative immunosuppression related to the stress response to surgery and general anesthesia. However, it remains to be determined whether regional anesthesia improves oncologic outcome after surgery.

Research Grants82

  1. ACUTE TOLERANCE IN ANESTHETIC ACTIONS AND INTERACTIONS
    Igor Kissin; Fiscal Year: 2001
    ..This was based on the suggestion that the spectrum of effects that constitutes the state of general anesthesia should not be regarded as several components of anesthesia resulting from one anesthetic action, but as ..
  2. SYNAPTIC MECHANISMS OF GENERAL ANESTHETIC ACTION
    Hugh C Hemmings; Fiscal Year: 2011
    ..produces amnesia, unconsciousness or immobilization (with increasing doses), the cardinal features of general anesthesia. Anesthetics have potent and specific effects on synaptic transmission, including both presynaptic actions ..
  3. Connexins in Neuronal and Glial Gap Junctions in the Central Nervous System
    John E Rash; Fiscal Year: 2010
    ..awake states, how consciousness is altered during general anesthesia, and how memories are created, and will also be essential for identifying subcellular sites that may become ..
  4. STRUCTURE OF GABA-A RECEPTOR ANION-SELECTIVE CHANNEL
    Myles H Akabas; Fiscal Year: 2010
    ..are targets for drugs used to treat anxiety disorders, insomnia, epilepsy and muscle spasm, as well as for general anesthesia. A long term goal of molecular neuroscience, and of this project, has been to understand the structural ..
  5. Neonatal Anesthetic Neurotoxicity
    Piyush M Patel; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): A premise of general anesthesia is that anesthetics produce a non-toxic and reversible state of unconsciousness...
  6. A Systems Neuroscience Approach for the Study of General Anesthesia
    Emery Brown; Fiscal Year: 2009
    b>General anesthesia is a drug-induced, reversible condition comprised of five behavioral states: hypnosis (loss of consciousness), amnesia (loss of memory), analgesia (loss of pain sensation), akinesia (immobility), and hemodynamic ..
  7. Diagnosis of Subglottic Stenosis and Edema in Neonates Using OCT
    Brian Wong; Fiscal Year: 2010
    ..Surgical endoscopy has remained the gold standard in the diagnosis of SGS. Unfortunately, surgery requires general anesthesia and is limited to the characterization of the surface anatomy and does not provide detailed analysis of the ..
  8. Preclinical Studies of Carbo-etomidate: An Etomidate Analogue for Use in Sepsis
    Douglas E Raines; Fiscal Year: 2010
    ..Patients with sepsis commonly need general anesthesia for important therapeutic interventions such as intubation and surgery...
  9. Macrophage-based Human Gene Therapy for Hereditary PAP
    Bruce C Trapnell; Fiscal Year: 2011
    ..Current therapy is whole lung lavage, a procedure performed under general anesthesia in which one lung is mechanical ventilated while the other is repeatedly filled with warmed saline, ..
  10. Redesigning General Anesthesia
    Matthew A Wilson; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): General anesthesia is a reversible, drug-induced behavioral state comprised of unconsciousness, amnesia, analgesia and immobility with stability and control of vital physiological systems...
  11. Office based Real-time high Speed 3-D OCT system for Diagnosis of EarlyLaryngeal
    TIRUNELVELI RAMALINGAM; Fiscal Year: 2010
    ..Therefore, laryngeal cancer diagnosis has to rely on biopsies, which requires general anesthesia and surgical endoscopy...
  12. Actuated Fine-Gauge Spinal Needle Insertion to Reduce Dura Damage and PDPH Risk
    MAUREEN L MULVIHILL; Fiscal Year: 2012
    ..Spinal anesthesia provides many benefits over general anesthesia including decreased blood loss, decreased post-anesthesia nausea and vomiting, and better post-op pain ..
  13. Does Anesthetic Solubility Determine Receptor Specificity?
    ROBERT JOSEPH BROSNAN; Fiscal Year: 2010
    ..of a drug and the specificity of that drug for receptors that may mediate immobility and/or amnesia during general anesthesia. We have collected extensive preliminary data that suggest drug modulation of at least two anesthetic-..
  14. Neuromuscular blocker-induced asthma during anesthesia
    Charles Emala; Fiscal Year: 2005
    ..It was developed specifically to facilitate tracheal intubation during the induction of general anesthesia, but has been associated with life threatening bronchospasm...
  15. Neuromuscular blocker-induced asthma during anesthesia
    Charles Emala; Fiscal Year: 2004
    ..It was developed specifically to facilitate tracheal intubation during the induction of general anesthesia, but has been associated with life threatening bronchospasm...
  16. Neuromuscular blocker-induced asthma during anesthesia
    Charles Emala; Fiscal Year: 2003
    ..It was developed specifically to facilitate tracheal intubation during the induction of general anesthesia, but has been associated with life threatening bronchospasm...
  17. Neuromuscular blocker-induced asthma during anesthesia
    Charles Emala; Fiscal Year: 2006
    ..It was developed specifically to facilitate tracheal intubation during the induction of general anesthesia, but has been associated with life threatening bronchospasm...
  18. VOLATILE ANESTHETIC INTERACTIONS WITH GABA-A RECEPTORS
    Neil Harrison; Fiscal Year: 1991
    Many theories have been proposed concerning the mechanisms of general anesthesia Several of these, including the lipid theory and the critical volume hypothesis, make some useful predictions but fail to illuminate the nature of the events ..
  19. DETERMINANTS OF H. INFLUENZAE VIRULENCE IN OTITIS MEDIA
    Lauren O Bakaletz; Fiscal Year: 2011
    ..in reasons why children make physician's office and emergency room visits, undergo surgery requiring general anesthesia, and experience hearing loss...
  20. DETERMINANTS OF H. INFLUENZAE VIRULENCE IN OTITIS MEDIA
    Lauren O Bakaletz; Fiscal Year: 2010
    ..in reasons why children make physician's office and emergency room visits, undergo surgery requiring general anesthesia, and experience hearing loss...
  21. ANESTHETIC MECHANISMS AND GABA-A RECEPTOR STRUCTURE
    MYLES AKABAS; Fiscal Year: 2001
    ..Many drugs used in the induction of general anesthesia, including benzodiazepines, volatile and intravenous anesthetics and barbiturates potentiate GABA-induced ..
  22. ANESTHETIC MECHANISMS AND GABA-A RECEPTOR STRUCTURE
    MYLES AKABAS; Fiscal Year: 2000
    ..Many drugs used in the induction of general anesthesia, including benzodiazepines, volatile and intravenous anesthetics and barbiturates potentiate GABA-induced ..
  23. Multimodal Functional Imaging of Auditory Perception Under General Anesthesia
    PATRICK PURDON; Fiscal Year: 2007
    A fundamental problem in neuroscience and medicine is to understand the mechanisms of general anesthesia. This proposal, "Multimodal Functional Imaging of Auditory Perception Under General Anesthesia", is submitted in response to the ..
  24. Multimodal Functional Imaging of Auditory Perception Under General Anesthesia
    PATRICK PURDON; Fiscal Year: 2009
    A fundamental problem in neuroscience and medicine is to understand the mechanisms of general anesthesia. This proposal, "Multimodal Functional Imaging of Auditory Perception Under General Anesthesia", is submitted in response to the ..
  25. Multimodal Functional Imaging of Auditory Perception Under General Anesthesia
    Patrick L Purdon; Fiscal Year: 2010
    A fundamental problem in neuroscience and medicine is to understand the mechanisms of general anesthesia. This proposal, "Multimodal Functional Imaging of Auditory Perception Under General Anesthesia", is submitted in response to the ..
  26. Anesthesia-induced Developmental Neuroapoptosis
    Vesna Jevtovic Todorovic; Fiscal Year: 2005
    Exposure of premature infants, neonates and very young children to general anesthesia is a frequent occurrence in modern medicine...
  27. Anesthesia-induced Developmental Neuroapoptosis
    Vesna Jevtovic Todorovic; Fiscal Year: 2007
    Exposure of premature infants, neonates and very young children to general anesthesia is a frequent occurrence in modern medicine...
  28. Anesthesia-induced Developmental Neuroapoptosis
    Vesna Jevtovic Todorovic; Fiscal Year: 2006
    Exposure of premature infants, neonates and very young children to general anesthesia is a frequent occurrence in modern medicine...
  29. Anesthesia-induced Developmental Neuroapoptosis
    Vesna Jevtovic Todorovic; Fiscal Year: 2009
    Exposure of premature infants, neonates and very young children to general anesthesia is a frequent occurrence in modern medicine...
  30. Anesthesia-induced Developmental Neuroapoptosis
    Vesna Jevtovic Todorovic; Fiscal Year: 2009
    Exposure of premature infants, neonates and very young children to general anesthesia is a frequent occurrence in modern medicine...
  31. CALCIUM CURRENT DEPRESSION BY VOLATILE ANESTHETICS
    Carl Lynch; Fiscal Year: 1991
    ..In addition to inducing general anesthesia, the inhalational anesthetics depress cardiac contractility largely by decreasing the delivery of Ca which ..
  32. GENERAL ANESTHETICS AND CLONED VOLTAGE-GATED CHANNELS
    ANA CORREA; Fiscal Year: 2000
    b>General anesthesia is a condition in which loss of memory and consciousness is accompanied by loss of pain sensation...
  33. GENERAL ANESTHETICS AND CLONED VOLTAGE-GATED CHANNELS
    ANA CORREA; Fiscal Year: 1999
    b>General anesthesia is a condition in which loss of memory and consciousness is accompanied by loss of pain sensation...
  34. Tumor NMR Images are Affected by Anesthetic
    Natarajan Raghunand; Fiscal Year: 2006
    ..Inducing and maintaining general anesthesia can produce profound changes in normal physiology...
  35. Tumor NMR Images are Affected by Anesthetic
    VICTORIA LUKASIK; Fiscal Year: 2005
    ..Inducing and maintaining general anesthesia can produce profound changes in normal physiology...
  36. Oral Health of Latino and Ethiopian Children and Their Mothers
    Olivia Carter Pokras; Fiscal Year: 2009
    ..effects are seen later in life and its treatment requires specialized care even in the operating room under general anesthesia. Early Childhood Caries is the presence of 1 or more decayed (noncavitated or cavitated lesions), missing (..
  37. MAPPING ELOQUENT CORTEX USING RESTING STATE CORTICAL PHYSIOLOGY
    JOSHUA S contact SHIMONY; Fiscal Year: 2011
    ..be used in all patients, can be performed both pre- and intra-operatively, and can be used in the setting of general anesthesia. New approaches based on resting state cortical physiology, such as functional connectivity MRI (fcMRI) and ..
  38. ACUTE TOLERANCE IN ANESTHETIC ACTIONS AND INTERACTIONS
    Igor Kissin; Fiscal Year: 1999
    ..This was based on the suggestion that the spectrum of effects that constitutes the state of general anesthesia should not be regarded as several components of anesthesia resulting from one anesthetic action, but as ..
  39. ACUTE TOLERANCE IN ANESTHETIC ACTIONS AND INTERACTIONS
    Igor Kissin; Fiscal Year: 2000
    ..This was based on the suggestion that the spectrum of effects that constitutes the state of general anesthesia should not be regarded as several components of anesthesia resulting from one anesthetic action, but as ..
  40. The Role of the Amygdala in Anesthetic-Induced Amnesia
    MICHAEL ALKIRE; Fiscal Year: 2006
    ..that the basolateral amygdala (BL) is critically nvolved with mediating the amnesic effects of propofol general anesthesia. Propofol does not produce amnesia if the BL is lesioned...
  41. The Role of the Amygdala in Anesthetic-Induced Amnesia
    MICHAEL ALKIRE; Fiscal Year: 2003
    ..that the basolateral amygdala (BL) is critically nvolved with mediating the amnesic effects of propofol general anesthesia. Propofol does not produce amnesia if the BL is lesioned...
  42. TRANSJUGULAR PORTASYSTEMIC SHUNTS/PARACENTESIS FOR TREATMENT OF ASCITES
    Arun Sanyal; Fiscal Year: 2000
    ..TIPS avoids the risk of general anesthesia and major surgery and has been shown to resolve the fluid retention problem in most patients...
  43. Connexins in Neuronal and Glial Gap Junctions in the Central Nervous System
    JOHN RASH; Fiscal Year: 2009
    ..awake states, how consciousness is altered during general anesthesia, and how memories are created, and will also be essential for identifying subcellular sites that may become ..
  44. Electromechanical reshaping of tissue
    Brian Wong; Fiscal Year: 2009
    ..suture" surgery, which has numerous disadvantages including shape memory, donor site morbidity, and usually general anesthesia. We have developed electromechanical reshaping (EMR), a novel minimally invasive technique that combines ..
  45. Electromechanical reshaping of tissue
    Brian Wong; Fiscal Year: 2010
    ..suture" surgery, which has numerous disadvantages including shape memory, donor site morbidity, and usually general anesthesia. We have developed electromechanical reshaping (EMR), a novel minimally invasive technique that combines ..
  46. METHODS OF ANESTHESIA AND ANALGESIA FOR AORTIC SURGERY
    Charles Beattie; Fiscal Year: 1993
    ..of medical resources have been suggested to result from using regional anesthetic techniques as compared to general anesthesia alone for large operative procedures...
  47. ANESTHETIC MECHANISMS BY IN VIVO BRAIN IMAGING
    Ferenc Gyulai; Fiscal Year: 2001
    ..This provides the first in vivo support in humans for the well known GABAA-R hypothesis of general anesthesia. To determine whether 11C- FMZ binding is a valid reflection of GABAA-R functional state in the living brain,..
  48. ANESTHETIC MECHANISMS BY IN VIVO BRAIN IMAGING
    Ferenc Gyulai; Fiscal Year: 2000
    ..This provides the first in vivo support in humans for the well known GABAA-R hypothesis of general anesthesia. To determine whether 11C- FMZ binding is a valid reflection of GABAA-R functional state in the living brain,..
  49. ANESTHETIC MECHANISMS BY IN VIVO BRAIN IMAGING
    Ferenc Gyulai; Fiscal Year: 2003
    ..This provides the first in vivo support in humans for the well known GABAA-R hypothesis of general anesthesia. To determine whether 11C- FMZ binding is a valid reflection of GABAA-R functional state in the living brain,..
  50. ANESTHETIC MECHANISMS BY IN VIVO BRAIN IMAGING
    Ferenc Gyulai; Fiscal Year: 2004
    ..This provides the first in vivo support in humans for the well known GABAA-R hypothesis of general anesthesia. To determine whether 11C- FMZ binding is a valid reflection of GABAA-R functional state in the living brain,..
  51. ANESTHETIC MECHANISMS BY IN VIVO BRAIN IMAGING
    Ferenc Gyulai; Fiscal Year: 2002
    ..This provides the first in vivo support in humans for the well known GABAA-R hypothesis of general anesthesia. To determine whether 11C- FMZ binding is a valid reflection of GABAA-R functional state in the living brain,..
  52. Presurgery Hypnosis--Benefits Analysis in Breast Cancer
    Guy Montgomery; Fiscal Year: 2002
    ..Despite improvements in pharmacological management, surgical procedures under general anesthesia continue to be associated with clinically significant side effects, chief among which are pain and nausea...
  53. Presurgery Hypnosis--Benefits Analysis in Breast Cancer
    Guy Montgomery; Fiscal Year: 2001
    ..Despite improvements in pharmacological management, surgical procedures under general anesthesia continue to be associated with clinically significant side effects, chief among which are pain and nausea...
  54. Presurgery Hypnosis--Benefits Analysis in Breast Cancer
    Guy Montgomery; Fiscal Year: 2003
    ..Despite improvements in pharmacological management, surgical procedures under general anesthesia continue to be associated with clinically significant side effects, chief among which are pain and nausea...
  55. Propofol Interactions with GABA-A Receptors
    MYLES AKABAS; Fiscal Year: 2006
    Each year millions of people undergo general anesthesia so that surgeons can perform life-saving operations...
  56. Propofol Interactions with GABA-A Receptors
    MYLES AKABAS; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Each year millions of people undergo general anesthesia so that surgeons can perform life-saving operations...
  57. Propofol Interactions with GABA-A Receptors
    MYLES AKABAS; Fiscal Year: 2007
    Each year millions of people undergo general anesthesia so that surgeons can perform life-saving operations...
  58. STRUCTURE OF GABA-A RECEPTOR ANION-SELECTIVE CHANNEL
    MYLES AKABAS; Fiscal Year: 2009
    ..are targets for drugs used to treat anxiety disorders, insomnia, epilepsy and muscle spasm, as well as for general anesthesia. A long term goal of molecular neuroscience, and of this project, has been to understand the structural ..
  59. Novel biofilm polymicrobial infection-resistant implants for otologic application
    Mohamed Labib; Fiscal Year: 2009
    ..Tympanostomy is the most common pediatric procedure under general anesthesia in the developed world...
  60. Anesthetic Effects on Ion Channel Structures & Dynamics
    Pei Tang; Fiscal Year: 2010
    ..in the Pi's laboratory using the computational approaches to elucidating the molecular mechanisms of general anesthesia. Research in the previous funding period challenged the traditional structure-function paradigm in ..
  61. ANESTHETIC ACTIONS IN SPINAL CORD
    Joan Kendig; Fiscal Year: 2000
    b>General anesthesia by inhalation agents has been an indispensable part of patient care for over 150 years, but to an extent unique among modern pharmacologic agents we do not understand how anesthetics work...
  62. Anesthetic Effects on Ion Channel Structures & Dynamics
    Pei Tang; Fiscal Year: 2010
    ..in the Pi's laboratory using the computational approaches to elucidating the molecular mechanisms of general anesthesia. Research in the previous funding period challenged the traditional structure-function paradigm in ..
  63. Anesthetic Effects on Ion Channel Structures & Dynamics
    Pei Tang; Fiscal Year: 2009
    ..in the Pi's laboratory using the computational approaches to elucidating the molecular mechanisms of general anesthesia. Research in the previous funding period challenged the traditional structure-function paradigm in ..
  64. ANESTHETIC ACTIONS IN SPINAL CORD
    Joan Kendig; Fiscal Year: 1999
    b>General anesthesia by inhalation agents has been an indispensable part of patient care for over 150 years, but to an extent unique among modern pharmacologic agents we do not understand how anesthetics work...
  65. Anesthetic Effects on Ion Channel Structures & Dynamics
    Pei Tang; Fiscal Year: 2007
    ..in the Pi's laboratory using the computational approaches to elucidating the molecular mechanisms of general anesthesia. Research in the previous funding period challenged the traditional structure-function paradigm in ..
  66. NEUROLOGICAL AND COGNITIVE OUTCOMES FOLLOWING CABG
    GUY MC KHANN; Fiscal Year: 2003
    ..room, but lack of appropriate control groups has precluded ruling out other causes including the effects of general anesthesia, Alzheimer's disease (AD) or depression...
  67. NEUROLOGICAL AND COGNITIVE OUTCOMES FOLLOWING CABG
    GUY MC KHANN; Fiscal Year: 2002
    ..room, but lack of appropriate control groups has precluded ruling out other causes including the effects of general anesthesia, Alzheimer's disease (AD) or depression...
  68. NEUROLOGICAL AND COGNITIVE OUTCOMES FOLLOWING CABG
    Ola Selnes; Fiscal Year: 2001
    ..room, but lack of appropriate control groups has precluded ruling out other causes including the effects of general anesthesia, Alzheimer's disease (AD) or depression...
  69. NEUROLOGICAL AND COGNITIVE OUTCOMES FOLLOWING CABG
    Ola Selnes; Fiscal Year: 2000
    ..room, but lack of appropriate control groups has precluded ruling out other causes including the effects of general anesthesia, Alzheimer's disease (AD) or depression...
  70. ACTION OF I V ANESTHETICS ON REGIONAL BLOOD FLOWS
    LAWRENCE PRIANO; Fiscal Year: 1980
    ..will be placed and either electromagnetic or Doppler ultrasonic flow probes implanted in dogs under general anesthesia 2-3 weeks prior to the studies...
  71. Global cortical dynamics in sleep and general anesthesia
    Eran A Mukamel; Fiscal Year: 2012
    ..organized? The brain's ability to operate in distinct global states, including waking, sleep, and general anesthesia, is critical for human health and medicine...
  72. CARDIOVASCULAR DYNAMICS AND ANESTHETIC DISPOSITION
    PETER DAYTON; Fiscal Year: 1980
    ..All of these drugs are widely used along with nitrous oxide to produce general anesthesia, especially for patients with cardiovascular instability (e.g., cardiac disease, hypovolemia, shock)...
  73. Dectection of occult mediastinal lymph node mestastases
    Michael Wallace; Fiscal Year: 2007
    ..nodes either lack sensitivity (computed tomography, positron emission tomography), or are invasive requiring general anesthesia (mediastinoscopy, thoracoscopy)...
  74. Dectection of occult mediastinal lymph node mestastases
    Michael Wallace; Fiscal Year: 2002
    ..nodes either lack sensitivity (computed tomography, positron emission tomography), or are invasive requiring general anesthesia (mediastinoscopy, thoracoscopy)...
  75. Dectection of occult mediastinal lymph node mestastases
    Michael Wallace; Fiscal Year: 2006
    ..nodes either lack sensitivity (computed tomography, positron emission tomography), or are invasive requiring general anesthesia (mediastinoscopy, thoracoscopy)...
  76. NonInvasive Optical Imaging of Vocal Cord Microstructure
    Brian Wong; Fiscal Year: 2004
    ..of many true vocal cord (TVC) lesions requires biopsy or excision which exposes the patient to the risks of general anesthesia, TVC injury, and potential iatrogenic glottic speech impairment...
  77. ANESTHETICS' MECHANISMS OF ACTION--PRESYNAPTIC SITES
    M MacIver; Fiscal Year: 1993
    ..Increased synaptic inhibition is thought to play a significant role in the CNS depression associated with general anesthesia. The long-term goal of the proposed research is to define the synaptic sites of action which contribute to ..