general anesthesia

Summary

Top Publications

  1. ncbi Comparison of spinal and general anesthesia in lumbar laminectomy surgery: a case-controlled analysis of 400 patients
    Robert F McLain
    The Cleveland Clinic Spine Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Neurosurg Spine 2:17-22. 2005
  2. pmc TREK-1, a K+ channel involved in neuroprotection and general anesthesia
    C Heurteaux
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS, Institut Paul Hamel, Sophia Antipolis, Valbonne, France
    EMBO J 23:2684-95. 2004
  3. ncbi Does dexmedetomidine prevent emergence delirium in children after sevoflurane-based general anesthesia?
    Mohanad Shukry
    Department of Anesthesiology, Tulane University, New Orleans, LA, USA
    Paediatr Anaesth 15:1098-104. 2005
  4. ncbi General anesthesia activates BDNF-dependent neuroapoptosis in the developing rat brain
    Lucy X Lu
    Department of Anasthesiology, University of Virginia Health System, P O Box 800710, Charlottesville, 22908, USA
    Apoptosis 11:1603-15. 2006
  5. ncbi Propofol induction reduces the capacity for neural information integration: implications for the mechanism of consciousness and general anesthesia
    UnCheol Lee
    Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI 48109 0048, USA
    Conscious Cogn 18:56-64. 2009
  6. pmc Spine Surgery under general anesthesia may not increase the risk of Alzheimer's disease
    Chaoshun Zuo
    Duke University, Durham, NC, USA
    Dement Geriatr Cogn Disord 29:233-9. 2010
  7. ncbi Laryngotracheal topicalization with lidocaine before intubation decreases the incidence of coughing on emergence from general anesthesia
    Sean C Minogue
    Department of Anesthesia, Vancouver General Hospital and the University of British Columbia, Vancouver, BC, Canada
    Anesth Analg 99:1253-7, table of contents. 2004
  8. ncbi Spinal versus general anesthesia for orthopedic surgery: anesthesia drug and supply costs
    Christopher Gonano
    Department of Anesthesiology and General Intensive Care, Medical University of Vienna, Austria
    Anesth Analg 102:524-9. 2006
  9. ncbi Effects of sevoflurane general anesthesia: immunological studies in mice
    N R Puig
    Institute of Immunology, School of Medicine, National University of Rosario, Santa Fe, Argentina
    Int Immunopharmacol 2:95-104. 2002
  10. ncbi Mechanisms of actions of inhaled anesthetics
    Jason A Campagna
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 348:2110-24. 2003

Detail Information

Publications280 found, 100 shown here

  1. ncbi Comparison of spinal and general anesthesia in lumbar laminectomy surgery: a case-controlled analysis of 400 patients
    Robert F McLain
    The Cleveland Clinic Spine Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Neurosurg Spine 2:17-22. 2005
    ..Application of regional anesthetics is widely preferred for lower-extremity surgery, but general anesthesia is used almost exclusively in spine surgery, despite evidence that spinal anesthesia is as safe and may ..
  2. pmc TREK-1, a K+ channel involved in neuroprotection and general anesthesia
    C Heurteaux
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS, Institut Paul Hamel, Sophia Antipolis, Valbonne, France
    EMBO J 23:2684-95. 2004
    ..Trek1-/- mice are also resistant to anesthesia by volatile anesthetics. TREK-1 emerges as a potential innovative target for developing new therapeutic agents for neurology and anesthesiology...
  3. ncbi Does dexmedetomidine prevent emergence delirium in children after sevoflurane-based general anesthesia?
    Mohanad Shukry
    Department of Anesthesiology, Tulane University, New Orleans, LA, USA
    Paediatr Anaesth 15:1098-104. 2005
    Emergence agitation or delirium (ED) is a frequent phenomenon in children recovering from general anesthesia (GA)...
  4. ncbi General anesthesia activates BDNF-dependent neuroapoptosis in the developing rat brain
    Lucy X Lu
    Department of Anasthesiology, University of Virginia Health System, P O Box 800710, Charlottesville, 22908, USA
    Apoptosis 11:1603-15. 2006
    ..beta-estradiol, a sex hormone that upregulates the protein levels of the activated Akt, protects against anesthesia-induced neuroapoptosis...
  5. ncbi Propofol induction reduces the capacity for neural information integration: implications for the mechanism of consciousness and general anesthesia
    UnCheol Lee
    Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI 48109 0048, USA
    Conscious Cogn 18:56-64. 2009
    The cognitive unbinding paradigm suggests that the synthesis of neural information is attenuated by general anesthesia. Here, we analyzed the functional organization of brain activities in the conscious and anesthetized states, based on ..
  6. pmc Spine Surgery under general anesthesia may not increase the risk of Alzheimer's disease
    Chaoshun Zuo
    Duke University, Durham, NC, USA
    Dement Geriatr Cogn Disord 29:233-9. 2010
    Volatile anesthetics cause Alzheimer's disease (AD)-like neuropathology in animals. We determined whether spine surgery under general anesthesia and anesthetic choice contributed to AD development.
  7. ncbi Laryngotracheal topicalization with lidocaine before intubation decreases the incidence of coughing on emergence from general anesthesia
    Sean C Minogue
    Department of Anesthesia, Vancouver General Hospital and the University of British Columbia, Vancouver, BC, Canada
    Anesth Analg 99:1253-7, table of contents. 2004
    ..022). This study supports the use of endotracheal lidocaine before intubation in patients undergoing general anesthesia for surgery <2 h duration where coughing on emergence is undesirable.
  8. ncbi Spinal versus general anesthesia for orthopedic surgery: anesthesia drug and supply costs
    Christopher Gonano
    Department of Anesthesiology and General Intensive Care, Medical University of Vienna, Austria
    Anesth Analg 102:524-9. 2006
    ..surgeries are common orthopedic interventions that can be performed with spinal anesthesia (SA) or general anesthesia (GA)...
  9. ncbi Effects of sevoflurane general anesthesia: immunological studies in mice
    N R Puig
    Institute of Immunology, School of Medicine, National University of Rosario, Santa Fe, Argentina
    Int Immunopharmacol 2:95-104. 2002
    ....
  10. ncbi Mechanisms of actions of inhaled anesthetics
    Jason A Campagna
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 348:2110-24. 2003
  11. ncbi Prediction of difficult mask ventilation
    O Langeron
    Departement d Anesthesie Reanimation, Centre Hospitalo Universitaire Pitie Salpetriere, Universite Paris VI, Paris, France
    Anesthesiology 92:1229-36. 2000
    ..Because the incidence of difficult mask ventilation (DMV) and the factors associated with it are not well known, we undertook this prospective study...
  12. ncbi Pain relief after arthroscopic shoulder surgery: a comparison of intraarticular analgesia, suprascapular nerve block, and interscalene brachial plexus block
    François J Singelyn
    Department of Anesthesiology, School of Medicine, Catholic University of Louvain, St Luc Hospital, Avenue Hippocrate 10 1821, B 1200 Brussels, Belgium
    Anesth Analg 99:589-92, table of contents. 2004
    ..25% bupivacaine. A control group was included for comparison. General anesthesia was administered to all patients. Patients were observed during the first 24 h...
  13. ncbi Difficult Airway Society guidelines for management of the unanticipated difficult intubation
    J J Henderson
    Anaesthetic Department, Gartnavel General Hospital, 1053 Great Western Road, Glasgow G12 0YN, UK
    Anaesthesia 59:675-94. 2004
    ..The flow-charts are simple, clear and definitive. They can be fully implemented only when the necessary equipment and training are available. The guidelines received overwhelming support from the membership of the DAS...
  14. ncbi The intubating laryngeal mask airway after induction of general anesthesia versus awake fiberoptic intubation in patients with difficult airways
    H S Joo
    Department of Anaesthesia, University of Toronto, Toronto, Ontario, Canada
    Anesth Analg 92:1342-6. 2001
    ..01). The ILMA is a useful device in the management of patients with difficult airways and may be a valuable alternative to AFOI when AFOI is contraindicated or in the patient with the unanticipated difficult airway...
  15. ncbi Quantifying cortical activity during general anesthesia using wavelet analysis
    Tatjana Zikov
    Department of Electrical and Computer Engineering, The University of British Columbia, Vancouver, BC V6T 1Z4, Canada
    IEEE Trans Biomed Eng 53:617-32. 2006
    This paper reports on a novel method for quantifying the cortical activity of a patient during general anesthesia as a surrogate measure of the patient's level of consciousness...
  16. ncbi General anesthesia for surgery influences melatonin and cortisol levels
    Edward Ram
    Department of General Surgery, Nazareth Hospital EMMS, Nazareth, Israel
    World J Surg 29:826-9. 2005
    The purpose of this study was to investigate the effect of general anesthesia and surgery on melatonin production, and to assess the relationship between melatonin secretion and cortisol levels...
  17. ncbi Effect of low tidal volume ventilation on atelectasis in patients during general anesthesia: a computed tomographic scan
    Hongwei Cai
    Department of Anesthesiology and Intensive Care Medicine, Xiangya Hospital, Central Southern University, Changsha, 41008, China
    J Clin Anesth 19:125-9. 2007
    To determine whether low tidal ventilation in patients without lung injury results in an increase in the amount of atelectasis and a further impairment of gas exchange during general anesthesia.
  18. ncbi Preoxygenation is more effective in the 25 degrees head-up position than in the supine position in severely obese patients: a randomized controlled study
    Benjamin J Dixon
    Australian Center for Obesity Research and Education, Monash University, Alfred Hospital, Melbourne 3181, Victoria, Australia
    Anesthesiology 102:1110-5; discussion 5A. 2005
    ..The authors explored the hypothesis that preoxygenation in the 25 degrees head-up position allows a greater safety margin for induction of anesthesia than the supine position...
  19. ncbi Stress hormone changes in general anesthesia of long duration: isoflurane-nitrous oxide vs sevoflurane-nitrous oxide anesthesia
    Tomoki Nishiyama
    Department of Anesthesiology, Faculty of Medicine, The University of Tokyo, 113 8655 Tokyo, Japan
    J Clin Anesth 17:586-91. 2005
    There are few comparative studies of stress hormone changes during general anesthesia with long duration between isoflurane-nitrous oxide and sevoflurane-nitrous oxide anesthesia...
  20. ncbi The effects of pneumoperitoneum on respiratory mechanics during general anesthesia for bariatric surgery
    Abdelazeem Ali El-Dawlatly
    Department of Anaesthesia, College of Medicine, King Saud University, King Khalid University Hospital, Riyadh, Saudia Arabia
    Obes Surg 14:212-5. 2004
    ..The effects of pneumoperitoneum (PPM) on respiratory mechanics during bariatric surgery were investigated...
  21. pmc A combination therapy of ethanol injection and radiofrequency ablation under general anesthesia for the treatment of hepatocellular carcinoma
    Kazutaka Kurokohchi
    Department of Gastroenterology, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    World J Gastroenterol 14:2037-43. 2008
    ..the effects of laparoscopic ethanol injection and radiofrequency ablation (L-EI-RFA), thoracoscopic (T-EI-RFA) and open-surgery assisted EI-RFA (O-EI-RFA) under general anesthesia for the treatment of hepatocellular carcinoma (HCC).
  22. ncbi Prevention of atelectasis in morbidly obese patients during general anesthesia and paralysis: a computerized tomography study
    Henrik Reinius
    Department of Anesthesia and Intensive Care, University Hospital, Uppsala, Sweden
    Anesthesiology 111:979-87. 2009
    ..This study analyzed the effect of general anesthesia and three different ventilatory strategies to reduce the amount of atelectasis and improve respiratory ..
  23. ncbi Spinal-epidural anesthesia versus general anesthesia in the management of percutaneous nephrolithotripsy
    Serap Karacalar
    Department of Anesthesiology, Ondokuz Mayis University, Samsun, Turkey
    J Endourol 23:1591-7. 2009
    To compare the efficacy between combined spinal-epidural block and general anesthesia in patients undergoing percutaneous nephrolithotripsy (PNL).
  24. ncbi Stress-induced cardiomyopathy following cephalosporin-induced anaphylactic shock during general anesthesia
    Eun Ha Suk
    Department of Anesthesiology and Pain Medicine, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea
    Can J Anaesth 56:432-6. 2009
    Anaphylaxis may be caused by various agents during general anesthesia. Sympathetic discharge may occur during anaphylaxis, which can trigger transient cardiomyopathy...
  25. ncbi Amyotrophic lateral sclerosis: the Midwestern surgical experience with the diaphragm pacing stimulation system shows that general anesthesia can be safely performed
    Raymond P Onders
    Department of Surgery, University Hospitals Case Medical Center, Detroit, MI, USA
    Am J Surg 197:386-90. 2009
    There is a paucity of literature concerning general anesthesia and surgery in patients with amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease)...
  26. ncbi Regional or general anesthesia for carotid endarterectomy? Evidence from published prospective and retrospective studies
    Joanne Guay
    Department of Anesthesia, Maisonneuve Rosemont Hospital, University of Montreal, Montreal, Quebec, Canada
    J Cardiothorac Vasc Anesth 21:127-32. 2007
    The aim of this study was to compare outcomes of patients undergoing carotid endarterectomy under regional or general anesthesia for any new neurologic impairment, stroke, stroke and/or death, death, and myocardial infarction.
  27. ncbi The effects of valerian on the time course of emergence from general anesthesia in Sprague-Dawley rats (Rattus norvegicus)
    Robert L Chaplin
    U S Air Force Academy, Colorado, USA
    AANA J 75:431-5. 2007
    ..These data demonstrate the need for continued research concerning the effects of herbals and their potential for interaction with anesthetics...
  28. ncbi Epidural plus general anesthesia vs general anesthesia alone for elective aortic surgery: effects on gastric electrical activity and serum gastrin secretion
    L Lombardo
    Department of Gastroenterology, Mauriziano U I Hospital, Turin, Italy
    Minerva Anestesiol 75:109-15. 2009
    ..of this study was to evaluate differences in electrogastrographic activity and serum gastrin secretion in patients subjected to general anesthesia (GA) vs blended anesthesia (BA = GA plus epidural analgesia) for abdominal aortic surgery.
  29. ncbi Frequency of anesthesia-related complications in children with Down syndrome under general anesthesia for noncardiac procedures
    Lawrence M Borland
    Department of Pediatric Anesthesiology, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Paediatr Anaesth 14:733-8. 2004
    ..Craniofacial and cardiac anomalies of Down syndrome (DS; trisomy 21) would seem to place these patients at higher risk of anesthesia-related complications (ARCs), but to date no comprehensive large-scale study has quantified this risk...
  30. ncbi Minimally invasive parathyroidectomy using cervical block: reasons for conversion to general anesthesia
    Tobias Carling
    Yale University School of Medicine, New Haven, CT 06510, USA
    Arch Surg 141:401-4; discussion 404. 2006
    We investigated the frequency and reasons for conversion from cervical block anesthesia to general anesthesia (GA) in patients undergoing minimally invasive parathyroidectomy for primary hyperparathyroidism.
  31. ncbi Takotsubo cardiomyopathy after general anesthesia for eye surgery
    Doron Gavish
    Department of Anesthesia, The Edith Wolfson Medical Center, Holon, Israel
    Anesthesiology 105:621-3. 2006
  32. ncbi Positron emission tomography study of regional cerebral metabolism during general anesthesia with xenon in humans
    Steffen Rex
    Department of Anesthesiology, University Hospital, RWTH Aachen, Aachen, Germany
    Anesthesiology 105:936-43. 2006
    ..Therefore, the authors hypothesized that xenon, similar to ketamine and nitrous oxide, increases global and regional cerebral metabolism in humans...
  33. ncbi Suppression of cough during emergence from general anesthesia: laryngotracheal lidocaine through a modified endotracheal tube
    C A Diachun
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305 5640, USA
    J Clin Anesth 13:447-51. 2001
    To ascertain if coughing during emergence from general anesthesia can be suppressed with a modified endotracheal tube.
  34. ncbi A prospective randomized study comparing perioperative outcome variables after epidural or general anesthesia for lumbar disc surgery
    Cengiz Bekir Demirel
    Department of Anesthesiology, University of Zonguldak Karaelmas, Faculty of Medicine, Zonguldak, Turkey
    J Neurosurg Anesthesiol 15:185-92. 2003
    ..The aim of this study was to assess the superiority of general anesthesia or epidural anesthesia techniques in lumbar laminectomy and discectomy...
  35. ncbi The effect of skin incision on the electroencephalogram during general anesthesia maintained with propofol or desflurane
    James W Sleigh
    Department of Anesthesia, Waikato Clinical School of the University of Auckland, Waikato Hospital, Hamilton, 3206, New Zealand
    J Clin Monit Comput 24:307-18. 2010
    A variety of effects of surgical incision on the electroencephalogram (EEG) during modern general anesthesia have been previously described; including both increases and decreases in both high and low frequencies in the EEG...
  36. ncbi Medicaid costs associated with the hospitalization of young children for restorative dental treatment under general anesthesia
    M J Kanellis
    Department of Pediatric Dentistry, University of Iowa, Iowa City 52242, USA
    J Public Health Dent 60:28-32. 2000
    This paper examines the cost to the Iowa Medicaid program of hospitalizing young children for restorative dental care under general anesthesia, and describes the dental services received in this setting.
  37. ncbi Regional anesthesia is a good alternative to general anesthesia in pediatric surgery: Experience in 1,554 children
    Sema Uguralp
    Departments of Pediatric Surgery and Anesthesiology, Turgut Ozal Medical Center, Inonu University, Faculty of Medicine, Malatya, Turkey
    J Pediatr Surg 37:610-3. 2002
    ..and spinal blocks are modern and safe techniques, in many centers children still are operated on under general anesthesia (GA), or the blocks are used for postoperative analgesia after GA in infraumbilical operations...
  38. ncbi Preoperative combined with intraoperative skin-surface warming avoids hypothermia caused by general anesthesia and surgery
    Simone Maria D Angelo Vanni
    Department of Anesthesiology, School of Medicine of the University of São Paulo State, Botucatu, Sao Paulo, Brazil
    J Clin Anesth 15:119-25. 2003
    ....
  39. ncbi The effects of intracuff lidocaine on endotracheal-tube-induced emergence phenomena after general anesthesia
    C Fagan
    Department of Anesthesia, St James s Hospital and St Vincent s Hospital, Dublin, Ireland
    Anesth Analg 91:201-5. 2000
    Coughing during emergence from general anesthesia is a common clinical problem...
  40. ncbi Prevention of atelectasis formation during induction of general anesthesia
    Marco Rusca
    Departments of Anesthesiology, University Hospital, Lausanne, Switzerland
    Anesth Analg 97:1835-9. 2003
    b>General anesthesia promotes atelectasis formation, which is augmented by administration of large oxygen concentrations...
  41. pmc General anesthesia causes long-lasting disturbances in the ultrastructural properties of developing synapses in young rats
    N Lunardi
    Department of Anesthesiology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Neurotox Res 17:179-88. 2010
    ..We believe that observed morphological disturbances of developing synapses may, at least in part, contribute to the learning and memory deficits that occur later in life after exposure of the immature brain to general anesthesia.
  42. ncbi Remifentanil for cesarean section under general anesthesia: effects on maternal stress hormone secretion and neonatal well-being: a randomized trial
    G Draisci
    Istituto di Anestesiologia e Rianimazione, Dipartimento di Emergenza e Accettazione Istituto di Chimica Clinica, Universita Cattolica del Sacro Cuore, Istituto Superiore di Sanita, Rome, Italy
    Int J Obstet Anesth 17:130-6. 2008
    Remifentanil may attenuate maternal hemodynamic response during cesarean section under general anesthesia, but could cause transient but significant neonatal depression...
  43. ncbi Single-injection paravertebral block before general anesthesia enhances analgesia after breast cancer surgery with and without associated lymph node biopsy
    Pekka M Kairaluoma
    Department of Anesthesia and Intensive Care Medicine, Helsinki University Hospital, PO Box 580, Helsinki, FIN 00029 HUS, Finland
    Anesth Analg 99:1837-43, table of contents. 2004
    ..5 mg/kg) or saline before general anesthesia. The patient and attending investigators were blinded; the PVB or the sham block was performed behind a ..
  44. ncbi The memory effects of general anesthesia persist for weeks in young and aged rats
    Deborah J Culley
    Department of Anesthesia, Harvard Medical School, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Anesth Analg 96:1004-9, table of contents. 2003
    ..We tested the hypothesis that general anesthesia contributes to this cognitive impairment...
  45. ncbi Ultrasound-guided axillary brachial plexus block with 20 milliliters local anesthetic mixture versus general anesthesia for upper limb trauma surgery: an observer-blinded, prospective, randomized, controlled trial
    Brian D O'Donnell
    Department of Anesthesia, Cork University Hospital, Wilton Rd, Cork, Ireland
    Anesth Analg 109:279-83. 2009
    We performed a randomized, controlled trial comparing low-dose ultrasound-guided axillary block with general anesthesia evaluating anesthetic and perioperative analgesic outcomes.
  46. ncbi Mitochondrial perturbations and oxidant stress in lymphocytes from patients undergoing surgery and general anesthesia
    G Delogu
    Institute of Anesthesia and Intensive Care, Policlinico Umberto I, La Sapienza University, 00161 Rome, Italy
    Arch Surg 136:1190-6. 2001
    ..that a profound suppression of immune function transiently occurs in patients who undergo surgery under general anesthesia. The decline in the absolute counts of peripheral blood lymphocytes constitutes a major factor accounting ..
  47. ncbi Safety of same day discharge in patients undergoing sutureless thyroidectomy: a comparison of local and general anesthesia
    William B Inabnet
    Division of Gastrointestinal and Endocrine Surgery, Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, New York, USA
    Thyroid 18:57-61. 2008
    ..The aim of this study was to assess the safety and efficacy of the electrothermal bipolar vessel sealing system in permitting ambulatory thyroid surgery under local anesthesia...
  48. ncbi Prevention of atelectasis formation during the induction of general anesthesia in morbidly obese patients
    Marta Coussa
    Department of Anesthesiology, University Hospital, Lausanne, Switzerland
    Anesth Analg 98:1491-5, table of contents. 2004
    Atelectasis caused by general anesthesia is increased in morbidly obese patients...
  49. ncbi The ability of pleth variability index to predict the hemodynamic effects of positive end-expiratory pressure in mechanically ventilated patients under general anesthesia
    Olivier Desebbe
    Hospices Civils de Lyon, Department of Anesthesiology and Intensive Care, Louis Pradel Hospital, Claude Bernard Lyon 1 University, INSERM ERI 22, Lyon, France
    Anesth Analg 110:792-8. 2010
    ..PVI can predict fluid responsiveness noninvasively in mechanically ventilated patients during general anesthesia. We hypothesized that PVI could predict the hemodynamic effects of 10 cm H2O positive end-expiratory ..
  50. ncbi Practical use of the raw electroencephalogram waveform during general anesthesia: the art and science
    Cambell Bennett
    Waikato Clinical School, Waikato Hospital, Hamilton, New Zealand
    Anesth Analg 109:539-50. 2009
    ..qEEG) monitors are often used to estimate depth of anesthesia and intraoperative recall during general anesthesia. As with any monitor, the processed numerical output is often misleading and has to be interpreted within a ..
  51. ncbi No sex differences in memory formation during general anesthesia
    Christopher A Stonell
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Melbourne, Australia
    Anesthesiology 105:920-6. 2006
    ..However, sex differences in memory formation have not been explored. Therefore, the authors investigated sex differences in the implicit and explicit memory formation during general anesthesia.
  52. ncbi A comparison of a silicone wire-reinforced tube with the Parker and polyvinyl chloride tubes for tracheal intubation through an intubating laryngeal mask airway in patients with normal airways undergoing general anesthesia
    Ghassan E Kanazi
    American University of Beirut Medical Center, Department of Anesthesiology, Beirut, Lebanon
    Anesth Analg 107:994-7. 2008
    ..We compared the blind intubation success rates among the silicone wire-reinforced tube, the Parker tube, and the PVC tube, and identified laryngeal structures preventing tracheal intubations through the ILMA...
  53. ncbi Implantation of electrodes for deep brain stimulation of the subthalamic nucleus in advanced Parkinson's disease with the aid of intraoperative microrecording under general anesthesia
    Frank Hertel
    Department of Neurosurgery, Brüderkrankenhaus, Trier, Germany
    Neurosurgery 59:E1138; discussion E1138. 2006
    ..The purpose of this study was to evaluate the feasibility of MER for DBS surgery under general anesthesia (GA) and to compare the data of intraoperative MER as well as the clinical data with that of the current ..
  54. ncbi Gender and recovery after general anesthesia combined with neuromuscular blocking drugs
    Frank F Buchanan
    Department of Anesthesia and Pain Management, Alfred Hospital, Melbourne, Australia
    Anesth Analg 102:291-7. 2006
    Previous studies suggest that women recover faster from general anesthesia than men, but it is unclear whether this is a result of a gender effect or differences in the pattern of drug administration or type of surgery...
  55. ncbi Hemodynamic and respiratory changes following dexmedetomidine administration during general anesthesia: sevoflurane vs desflurane
    Eric Deutsch
    School of Medicine, University of Missouri, Columbia, MO 65212, USA
    Paediatr Anaesth 17:438-44. 2007
    ..The current study evaluates the hemodynamic and respiratory effects of dexmedetomidine (DEX) when administered to children anesthetized with sevoflurane (SEVO) or desflurane (DES)...
  56. ncbi The dental patient with special needs: a review of indications for treatment under general anesthesia
    Nancy Dougherty
    Department of Pediatric Dentistry, North Bronx Healthcare Network, Bronx, New York, USA
    Spec Care Dentist 29:17-20. 2009
    b>General anesthesia (GA) can play an important role in the facilitation of dental treatment for individuals who present with challenging behaviors...
  57. ncbi [Effects of neuraxial block and general anesthesia on tumor metastasis in rats]
    Wei Zheng
    Department of Anesthesiology, Cancer Hospital, Sun Yat Sen University, Guangzhou 510060, China
    Nan Fang Yi Ke Da Xue Xue Bao 28:2218-20. 2008
    ..To investigate the effects of different anesthesia methods on immune surveillance and tumor metastasis in tumor-bearing rats...
  58. ncbi Predictors of hypotension after induction of general anesthesia
    David L Reich
    Department of Anesthesiology, Mount Sinai Medical Center, Box 1010, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Anesth Analg 101:622-8, table of contents. 2005
    Hypotension after induction of general anesthesia is a common event. In the current investigation, we sought to identify the predictors of clinically significant hypotension after the induction of general anesthesia...
  59. ncbi Combined epidural and general anesthesia for paediatric renal transplantation-a single center experience
    V R Shah
    Department of Anesthesia, Institute of Kidney Diseases and Research Center and Institute of Transplantation, Civil Hospital Campus, Asarwa, Ahmedabad, Gujarat, India
    Transplant Proc 40:3451-4. 2008
    ..The aim of this study was to assess the preliminary application, success and safety of combined epidural and general anesthesia in pediatric renal transplantation in a small cohort.
  60. ncbi Insulin secretion and glucose utilization are impaired under general anesthesia with sevoflurane as well as isoflurane in a concentration-independent manner
    Tadashi Tanaka
    Department of Anesthesiology, The Jikei University School of Medicine, 3 25 8 Nishishinbashi, Minato ku, Tokyo 105 8461, Japan
    J Anesth 19:277-81. 2005
    ..The dose-dependent effects of sevoflurane and isoflurane anesthesia on glucose tolerance were compared in humans...
  61. ncbi Does yawning represent a transient arousal-shift during intravenous induction of general anesthesia?
    Yoshiko Kasuya
    Division of Anesthesia, Gifu Red Cross Hospital, Japan
    Anesth Analg 101:382-4, table of contents. 2005
    Although yawning occurs frequently during the IV induction of general anesthesia, the significance of this response remains unknown...
  62. ncbi Perioperative desaturation and risk factors in general anesthesia
    Thida Uakritdathikarn
    Department of Anesthesiology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand
    J Med Assoc Thai 91:1020-9. 2008
    Despite advances in anesthetic technique, the incidence of perioperative desaturation in general anesthesia has remained high. Knowledge on factors associated with intraoperative desaturation is relatively scanty...
  63. ncbi Comparison of three anesthetic techniques for off-pump coronary artery bypass grafting: general anesthesia, combined general and high thoracic epidural anesthesia, or high thoracic epidural anesthesia alone
    Paul Kessler
    Department of Anesthesiology and Intensive Care Medicine, Orthopedic University Hospital, Friedrichsheim Foundation, Frankfurt, Germany
    J Cardiothorac Vasc Anesth 19:32-9. 2005
    This study compared general anesthesia (GA), combined GA plus thoracic epidural anesthesia (TEA), and TEA alone in patients scheduled for off-pump coronary artery bypass grafting.
  64. ncbi Office-based ambulatory anesthesia: Factors that influence patient satisfaction or dissatisfaction with deep sedation/general anesthesia
    Timothy T Coyle
    Department of Oral and Maxillofacial Surgery, University of Texas Health Science Center at Houston, Sugarland, TX 77478, USA
    J Oral Maxillofac Surg 63:163-72. 2005
    ..collected in an outcomes study in an attempt to identify factors that may be significant predictors of either patient satisfaction or dissatisfaction with deep sedation/general anesthesia (DS/GA) administered in an office-based setting.
  65. ncbi General anesthesia with remifentanil for Cesarean section in a patient with HELLP syndrome
    F Richa
    Department of Anesthesia and Intensive Care, Hotel Dieu de France Hospital, Saint Joseph University, Beirut, Lebanon
    Acta Anaesthesiol Scand 49:418-20. 2005
    ..Definitive therapy is delivery. Parturients HELLP syndrome often require general anesthesia for Cesarean section delivery...
  66. ncbi General anesthesia for patients with Brugada syndrome. A report of six cases
    Mihoko Inamura
    Department of Anesthesiology, Kitasato University Hospital, 1 15 1, Kitasato, Sagamihara, Kanagawa, 228 8555 Japan
    Can J Anaesth 52:409-12. 2005
    To review six cases of Brugada syndrome presenting for insertion of a cardioverter-defibrillator under general anesthesia.
  67. pmc Need and demand for sedation or general anesthesia in dentistry: a national survey of the Canadian population
    B Chanpong
    Faculty of Dentistry, University of Toronto, Toronto, Canada
    Anesth Prog 52:3-11. 2005
    The aim of this study was to assess the need and demand for sedation or general anesthesia (GA) for dentistry in the Canadian adult population. A national telephone survey of 1101 Canadians found that 9...
  68. ncbi Low-dose vasopressin infusion in patients with severe vasodilatory hypotension after prolonged hemorrhage during general anesthesia
    Isao Tsuneyoshi
    Department of Anesthesiology and Critical Care Medicine, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    J Anesth 19:170-3. 2005
    ..a hypotensive crisis in patients who suffered persistent hypotension after prolonged hemorrhage during general anesthesia. VP was infused in two posthemorrhagic vasodilatory shock patients when they remained persistently ..
  69. ncbi Characteristics of anesthetic agents used for induction and maintenance of general anesthesia
    Edmond I Eger
    Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0464, USA
    Am J Health Syst Pharm 61:S3-10. 2004
    ....
  70. ncbi Development of a screening tool to assess the suitability of people with a disability for oral care under sedation or general anesthesia
    Neeta T Prabhu
    Paediatric Dentistry, Westmead Hospital, Sydney, Australia
    Spec Care Dentist 28:145-58. 2008
    ..Agreement on behavior assessment between dentists and anesthesiologists was poor. The tool has the potential to identify which people with disabilities can be effectively allocated for treatment under sedation or GA...
  71. ncbi Influence of general anesthesia on pharmacokinetics of intravenous lidocaine infusion in horses
    Darien J Feary
    Veterinary Medical Teaching Hospital, University of California, Davis, CA 95616, USA
    Am J Vet Res 66:574-80. 2005
    ..To compare the disposition of lidocaine administered IV in awake and anesthetized horses...
  72. ncbi Supplemental oxygen causes increased signal intensity in subarachnoid cerebrospinal fluid on brain FLAIR MR images obtained in children during general anesthesia
    Chantal Frigon
    Department of Radiology, University of Washington School of Medicine, Seattle, Wash, USA
    Radiology 233:51-5. 2004
    To prospectively test the hypothesis that high levels of the fraction of inspired oxygen (Fio(2)) during general anesthesia cause subarachnoid cerebrospinal fluid (CSF) hyperintensity during fluid-attenuated inversion-recovery (FLAIR) ..
  73. ncbi Development and psychometric testing of a quality of recovery score after general anesthesia and surgery in adults
    P S Myles
    Department of Anaesthesia and Pain Management, Alfred Hospital, Victoria, Australia
    Anesth Analg 88:83-90. 1999
    ..001). This study demonstrates that the QoR Score has good validity, reliability, and clinical acceptability in patients undergoing many types of surgery...
  74. ncbi Goal oriented general anesthesia for Cesarean section in a parturient with a large intracranial epidermoid cyst
    C Imarengiaye
    Department of Anesthesia, Mount Sinai Hospital, Toronto, Canada
    Can J Anaesth 48:884-9. 2001
    ..To illustrate the anesthetic management of a term parturient with a large brain tumour scheduled for Cesarean section...
  75. ncbi [General anesthesia and increased aspiration risk]
    Svante Holmberg
    Lakartidningen 103:4033-7. 2006
  76. ncbi General anesthesia for ophthalmic surgery
    Kathryn E McGoldrick
    Department of Anesthesiology, New York Medical College, Valhalla, NY 10595, USA
    Ophthalmol Clin North Am 19:179-91. 2006
    ..of ophthalmic operations in the United States are performed with local anesthetic techniques, nonetheless general anesthesia may be either necessary or advisable in several challenging circumstances...
  77. ncbi Seizure length with sevoflurane and thiopental for induction of general anesthesia in electroconvulsive therapy: a randomized double-blind trial
    Keith G Rasmussen
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA
    J ECT 22:240-2. 2006
    ..Absolute values for seizure duration with both sevoflurane and thiopental are well within typical ranges for those seen with the more commonly used methohexital as anesthetic...
  78. ncbi Maternal and neonatal effects of remifentanil at induction of general anesthesia for cesarean delivery: a randomized, double-blind, controlled trial
    Warwick D Ngan Kee
    Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    Anesthesiology 104:14-20. 2006
    Use of remifentanil during general anesthesia for cesarean delivery has been described, but its maternal and neonatal effects have not been investigated by a controlled study.
  79. ncbi A new procedure of arytenoid adduction combined with type I thyroplasty under general anesthesia using a laryngeal mask
    Ryoji Tokashiki
    Department of Otolaryngology, Tokyo Medical University, Tokyo, Japan
    Acta Otolaryngol 127:328-31. 2007
    ..and arytenoid adduction of direct lateral cricoarytenoid (LCA) muscle pulling at the same time under general anesthesia using a laryngeal mask is reported...
  80. ncbi Evaluation of endoscopic retrograde cholangiopancreatography under conscious sedation and general anesthesia
    K Raymondos
    Dept of Anesthesia, Medical School of Hanover, Hanover, Germany
    Endoscopy 34:721-6. 2002
    In adults, general anesthesia is usually only provided during endoscopic retrograde cholangiopancreatography (ERCP) when prior attempts using conscious sedation have failed...
  81. ncbi Pediatric dental procedures under general anesthesia at the Amiri Hospital in Kuwait
    H Ibricevic
    Pediatric Dentistry Department, Al Amiri Dental Center, Kuwait
    J Clin Pediatr Dent 25:337-42. 2001
    ..9 yr) had received dental treatments under general anesthesia (GA) at Amiri Hospital. The mean number of dental procedures per child was 13.6 (SD+/-5...
  82. ncbi Women emerge from general anesthesia faster than men
    Pramila Bajaj
    Department of Anaesthesiology and Critical Care, R N T Medical College and Associated Group of Hospitals, Udaipur Rajasthan 313004, India
    Middle East J Anesthesiol 19:173-83. 2007
    ..Recovery from general anesthesia is dependent on factors governing drug sensitivity and drug disposition...
  83. ncbi Dental treatment under general anesthesia in healthy and medically compromised developmentally disabled children: a comparative study
    Juan Pablo Loyola-Rodriguez
    San Luis Potosi University, San Luis Potosi, SLP, Mexico
    J Clin Pediatr Dent 34:177-82. 2009
    To compare the type, number of procedures and working time of dental treatment provided under dental general anesthesia (DGA) in healthy and medically compromised/developmentally disabled children (MCDD children).
  84. ncbi The effect of forced-air warming during arthroscopic shoulder surgery with general anesthesia
    Hyung Seok Yoo
    Department of Anesthesiology and Pain Medicine, College of Medicine, Kyung Hee University, Seoul, South Korea
    Arthroscopy 25:510-4. 2009
    ..In both groups irrigation fluid at room temperature (22 degrees C) was used...
  85. ncbi Laparoscopic cholecystectomy under spinal versus general anesthesia: a prospective, randomized study
    Samer S Bessa
    Department of General Surgery, University of Alexandria, Alexandria, Egypt
    J Laparoendosc Adv Surg Tech A 20:515-20. 2010
    For laparoscopic cholecystectomy (LC), the use of spinal anesthesia may offer several advantages over general anesthesia. The aim of this prospective, randomized study was to compare the surgical outcome of LC performed under general ..
  86. ncbi Comprehensive dental treatment under general anesthesia in healthy and disabled children
    Pei Ying Lee
    Department of Pediatric Dentistry, Chang Gung Memorial Hospital at Taipei, Chang Gung University College of Medicine, Taoyuan, Taiwan
    Chang Gung Med J 32:636-42. 2009
    Differences in dental treatment under general anesthesia (GA) in healthy and disabled children are rarely reported...
  87. ncbi The relationship between current intensity for nerve stimulation and success of peripheral nerve blocks performed in pediatric patients under general anesthesia
    Harshad Gurnaney
    Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4399, USA
    Anesth Analg 105:1605-9, table of contents. 2007
    ..the relationship between the lowest current amperage used to obtain a motor response, the success rate and the incidence of neurological complications with peripheral nerve blocks (PNB) in pediatric patients under general anesthesia.
  88. doi Loss of effective connectivity during general anesthesia
    Michael T Alkire
    University of California, Irvine, California, USA
    Int Anesthesiol Clin 46:55-73. 2008
  89. ncbi Temperature control and recovery of bowel function after laparoscopic or laparotomic colorectal surgery in patients receiving combined epidural/general anesthesia and postoperative epidural analgesia
    Giorgio Danelli
    Department of Anesthesiology, Vita Salute University of Milano, IRCCS H S Raffaele, Milano, Italy
    Anesth Analg 95:467-71, table of contents. 2002
    ..surgery on temperature control in 44 patients undergoing colorectal surgery during a combined epidural/general anesthesia. A thoracic epidural block up to T4 was induced with 6-10 mL of 0...
  90. ncbi The effectiveness of 4% intracuff lidocaine in reducing coughing during emergence from general anesthesia in smokers undergoing procedures lasting less than 1.5 hours
    Laura E Wetzel
    University of Michigan Flint Hurley Medical Center Anesthesia Program, USA
    AANA J 76:105-8. 2008
    ..This study did not show a correlation between use of intracuff lidocaine and a decrease in emergence coughing in procedures lasting less than 1.5 hours in patients who smoke...
  91. ncbi Combined general/epidural anesthesia (ropivacaine 0.375%) versus general anesthesia for upper abdominal surgery
    Yuhong Li
    Department of Anesthesiology, First Affiliated Hospital, School of Medicine, Zhejiang University, People s Republic of China
    Anesth Analg 106:1562-5, table of contents. 2008
    We designed this study to investigate the effect of 0.375% ropivacaine on stress hormone responses and anesthetic requirements in combined epidural/general anesthesia for nephrectomy.
  92. ncbi [General anesthesia with remifentanil for a patient having sinoatrial block and constrictive pulmonary disorder]
    Yumiko Nishio
    Department of Anesthesiology, University of Occupational and Environmental Health, Kitakyushu 807 8555
    Masui 57:1002-4. 2008
    ..Respiratory dysfunction was not seen in the postoperative course. Our case suggests that remifentanil may be a suitable analgesic for patients with cardiac conduction abnormalities...
  93. ncbi The influence of inspired oxygen fraction and end-tidal carbon dioxide on post-cross-clamp cerebral oxygenation during carotid endarterectomy under general anesthesia
    Paul Picton
    Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Anesth Analg 110:581-7. 2010
    ..We performed this study to determine the influence of Fio(2) and end-tidal carbon dioxide (Petco(2)) on rSO(2) in patients undergoing CEA with general anesthesia during carotid cross-clamping.
  94. ncbi Optimal oxygen concentration during induction of general anesthesia
    Lennart Edmark
    Department of Anesthesiology and Intensive Care, Central Hospital, Vasteras, and Research Associate, Department of Medical Sciences, Clinical Physiology, University Hospital, Uppsala, Sweden
    Anesthesiology 98:28-33. 2003
    ..The use of 100% oxygen during induction of anesthesia may produce atelectasis. The authors investigated how different oxygen concentrations affect the formation of atelectasis and the fall in arterial oxygen saturation during apnea...
  95. ncbi Parental presence during induction enhances the effect of oral midazolam on emergence behavior of children undergoing general anesthesia
    Y C P Arai
    Multidisciplinary Pain Center, Aichi Medical University, School of Medicine, Aichi, Japan
    Acta Anaesthesiol Scand 51:858-61. 2007
    ..The aim of the present study was to test if a combination of mother presence and midazolam premedication is effective for improving emergence condition in children undergoing general anesthesia.
  96. ncbi Intraoperative myocardial ischemia in peripheral vascular surgery: general anesthesia vs combined sciatic and femoral nerve blocks
    Alexandre Yazigi
    Department of Anesthesia and Intensive Care, Hotel Dieu de France Hospital, Beirut, Lebanon
    J Clin Anesth 17:499-503. 2005
    The aim of this study was to compare the frequency of intraoperative myocardial ischemia in lower extremity vascular surgery with general anesthesia vs regional anesthesia via combined sciatic and femoral nerve blocks.
  97. ncbi 532 nm pulsed potassium-titanyl-phosphate laser treatment of laryngeal papillomatosis under general anesthesia
    James A Burns
    Department of Surgery, Harvard Medical School, Center for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Laryngoscope 117:1500-4. 2007
    ..This investigation provides the first report of the pulsed-KTP laser during microlaryngoscopy under general anesthesia.
  98. ncbi The clinical assessment of Glidescope in orotracheal intubation under general anesthesia
    F S Xue
    Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People s Republic of China
    Minerva Anestesiol 73:451-7. 2007
    ....
  99. ncbi The efficacy of caudal morphine or bupivacaine combined with general anesthesia on postoperative pain and neuroendocrine stress response in children
    Erkan Teyin
    Department of Anaesthesiology and Reanimation, Ege University Hospital, Bornova, Izmir, Turkey
    Paediatr Anaesth 16:290-6. 2006
    ....
  100. ncbi Intraarticular lesions in primary frozen shoulder after manipulation under general anesthesia
    Markus Loew
    Department of Shoulder and Elbow Surgery, University Hospital for Orthopaedic Surgery, Heidelberg, Germany
    J Shoulder Elbow Surg 14:16-21. 2005
    The aim of this study was to find intraarticular lesions after manipulation under general anesthesia in patients with primary frozen shoulder...
  101. ncbi Carotid Artery Stump Pressure (CASP) in 1135 consecutive endarterectomies under general anesthesia: an old method that survived the test of times
    T Jacob
    Division of Vascular Surgery, Maimonides Medical Center, Brooklyn, NY 11219, USA
    J Cardiovasc Surg (Torino) 48:677-81. 2007
    ..Herein, we attempt to demonstrate that CASP is a reliable test that does not need to be replaced by more sophisticated and expensive techniques...

Research Grants65

  1. ACUTE TOLERANCE IN ANESTHETIC ACTIONS AND INTERACTIONS
    Igor Kissin; Fiscal Year: 2001
    ..This was based on the suggestion that the spectrum of effects that constitutes the state of general anesthesia should not be regarded as several components of anesthesia resulting from one anesthetic action, but as ..
  2. Propofol Interactions with GABA-A Receptors
    MYLES AKABAS; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Each year millions of people undergo general anesthesia so that surgeons can perform life-saving operations...
  3. Dectection of occult mediastinal lymph node mestastases
    Michael Wallace; Fiscal Year: 2007
    ..nodes either lack sensitivity (computed tomography, positron emission tomography), or are invasive requiring general anesthesia (mediastinoscopy, thoracoscopy)...
  4. The Role of the Amygdala in Anesthetic-Induced Amnesia
    MICHAEL ALKIRE; Fiscal Year: 2006
    ..that the basolateral amygdala (BL) is critically nvolved with mediating the amnesic effects of propofol general anesthesia. Propofol does not produce amnesia if the BL is lesioned...
  5. ANESTHETIC MECHANISMS BY IN VIVO BRAIN IMAGING
    Ferenc Gyulai; Fiscal Year: 2004
    ..This provides the first in vivo support in humans for the well known GABAA-R hypothesis of general anesthesia. To determine whether 11C- FMZ binding is a valid reflection of GABAA-R functional state in the living brain,..
  6. Diagnosis of Subglottic Stenosis and Edema in Neonates Using OCT
    Brian Wong; Fiscal Year: 2013
    ..Surgical endoscopy has remained the gold standard in the diagnosis of SGS. Unfortunately, surgery requires general anesthesia and is limited to the characterization of the surface anatomy and does not provide detailed analysis of the ..
  7. Pathogenesis of Postoperative Cognitive Dysfunction
    Zhongcong Xie; Fiscal Year: 2013
    ..and A[unreadable] accumulation are associated with cognitive dysfunction, and that surgery without general anesthesia can also lead to POCD in humans, our Preliminary studies in mice have shown that open abdominal surgery ..
  8. Connexins in Neuronal and Glial Gap Junctions in the Central Nervous System
    John E Rash; Fiscal Year: 2012
    ..awake states, how consciousness is altered during general anesthesia, and how memories are created, and will also be essential for identifying subcellular sites that may become ..
  9. Macrophage-based Human Gene Therapy for Hereditary PAP
    Bruce C Trapnell; Fiscal Year: 2012
    ..Current therapy is whole lung lavage, a procedure performed under general anesthesia in which one lung is mechanical ventilated while the other is repeatedly filled with warmed saline, ..
  10. Novel biofilm polymicrobial infection-resistant implants for otologic application
    Paul Stoodley; Fiscal Year: 2010
    ..Tympanostomy is the most common pediatric procedure under general anesthesia in the developed world...
  11. Gluconeogenesis and Glycogenolysis - Role and Regulation
    Alan D Cherrington; Fiscal Year: 2013
    ..Three weeks before study catheters will be inserted under general anesthesia into the femoral artery, the hepatic portal vein and the hepatic vein, as well as in other vessels and sites ..
  12. DETERMINANTS OF H. INFLUENZAE VIRULENCE IN OTITIS MEDIA
    Lauren O Bakaletz; Fiscal Year: 2013
    ..in reasons why children make physician's office and emergency room visits, undergo surgery requiring general anesthesia, and experience hearing loss...
  13. Neonatal Anesthetic Neurotoxicity
    Piyush M Patel; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): A premise of general anesthesia is that anesthetics produce a non-toxic and reversible state of unconsciousness...
  14. Office based real-time high speed 3D-OCT system for diagnosis of early laryngeal
    TIRUNELVELI RAMALINGAM; Fiscal Year: 2013
    ..Therefore, laryngeal cancer diagnosis has to rely on biopsies, which requires general anesthesia and surgical endoscopy...
  15. Crosby_Gregory_Mechanisms of Post-Anesthetic CNS Dysfunction in Aging
    Gregory Crosby; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): General anesthesia is typically considered to be a rapidly and completely reversible state...
  16. The geriatric surgical patient: stress, anesthetics, and functional outcomes
    Stacie Deiner; Fiscal Year: 2012
    ..Our hypotheses: 1) Patients undergoing general anesthesia with TIVA will have better outcomes than patients who receive inhalational anesthesia...
  17. Electromechanical reshaping of tissue
    Brian Wong; Fiscal Year: 2010
    ..suture" surgery, which has numerous disadvantages including shape memory, donor site morbidity, and usually general anesthesia. We have developed electromechanical reshaping (EMR), a novel minimally invasive technique that combines ..
  18. SYNAPTIC MECHANISMS OF GENERAL ANESTHETIC ACTION
    Hugh C Hemmings; Fiscal Year: 2013
    ..produces amnesia, unconsciousness or immobilization (with increasing doses), the cardinal features of general anesthesia. Anesthetics have potent and specific effects on synaptic transmission, including both presynaptic actions ..
  19. Caregiver Illness Perception and Childs Early Childhood Caries Status
    Mary Beth Slusar; Fiscal Year: 2013
    ..the time of child's routine care dental visit (controls) and at the time of restorative treatment under general anesthesia in OR (case)...
  20. Cellular Mechanisms of Vasoregulation by Volatile Anesthetics
    Rostislav Bychkov; Fiscal Year: 2012
    ..K2P channels should lead to new targeted treatments of hypertension and stroke and will be of benefit for general anesthesia. PUBLIC HEALTH RELEVANCE: Cardiovascular disease, hypertension and stroke are leading causes of death in the ..
  21. NEURONAL BASIS UNDERLYING VOLATILE ANESTHETIC INDUCED HYPNOSIS
    MAX KELZ; Fiscal Year: 2013
    ..are safely used in the vast majority of the nation's 40 million patients who annually require general anesthesia;however, these drugs may harm a subset of vulnerable patients...
  22. Cognitive and socioemotional development after postnatal anesthesia
    Mark G Baxter; Fiscal Year: 2013
    ..Thus, early neurotoxic insults from general anesthesia may result in long-term impacts on human cognitive development, but it is not possible to address this ..
  23. Cellular Cholesterol Movement and Homeostasis
    Yvonne Lange; Fiscal Year: 2012
    ..A novel hypothesis for the mysterious molecular mechanism of general anesthesia is also proposed...
  24. Mechanisms of anesthesia mediaited neurotoxicity
    Huafeng Wei; Fiscal Year: 2012
    ..Ultimately we hope to develop a strategy to prevent these harmful effects. This research will increase our understanding of general anesthesia-mediated neurotoxicity and make a safer use of inhaled anesthetics to surgical patients.
  25. Anesthetic Sites in Transmembrance Peptides by NMR
    Pei Tang; Fiscal Year: 2012
    ..The ultimate goal of the study is to elucidating the molecular mechanisms of general anesthesia. The research in the previous funding periods has led the investigators to realize that protein global ..
  26. Adult Stem Cell Minimally Invasive Bone Marrow Harvester
    DANIEL LEWIS KRAFT; Fiscal Year: 2012
    ..technique (utilizing serial small volume needle extractions) is painful, low-volume, and often requires general anesthesia. RegenMed Systems owns an exclusive license from Stanford University for the core patents around a novel ..
  27. Anesthesia-induced developmental neurodegeneration
    VESNA JEVTOVIC TODOROVIC JEVTOVIC-TODOROVIC; Fiscal Year: 2013
    ..In addition to causing widespread apoptotic neurodegeneration in vulnerable brain regions, general anesthesia exposure at the peak of the brain growth spurt causes learning and memory deficiencies later in life...
  28. Early Validation of Urinary Biomarkers of Renal Obstruction
    RICHARD SANG YONG LEE; Fiscal Year: 2013
    ..constrained to imaging modalities that are invasive, expose the children to ionizing radiation, may require general anesthesia, and are limited by their subjective nature...
  29. Oral Health of Latino and Ethiopian Children and Their Mothers
    Olivia Carter Pokras; Fiscal Year: 2009
    ..effects are seen later in life and its treatment requires specialized care even in the operating room under general anesthesia. Early Childhood Caries is the presence of 1 or more decayed (noncavitated or cavitated lesions), missing (..
  30. A Systems Neuroscience Approach for the Study of General Anesthesia
    Emery N Brown; Fiscal Year: 2011
    b>General anesthesia is a drug-induced, reversible condition comprised of five behavioral states: hypnosis (loss of consciousness), amnesia (loss of memory), analgesia (loss of pain sensation), akinesia (immobility), and hemodynamic ..
  31. Global cortical dynamics in sleep and general anesthesia
    Eran A Mukamel; Fiscal Year: 2013
    ..organized? The brain's ability to operate in distinct global states, including waking, sleep, and general anesthesia, is critical for human health and medicine...
  32. A Neural Systems Approach to Monitoring and Drug-Delivery for General Anesthesia
    PATRICK PURDON; Fiscal Year: 2009
    DESCRIPTION (Provided by the applicant) Abstract: General anesthesia is a drug-induced, reversible condition comprised of five behavioral states: loss of consciousness, amnesia, analgesia, lack of movement, and hemodynamic stability...
  33. Redesigning General Anesthesia
    Matthew A Wilson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): General anesthesia is a reversible, drug-induced behavioral state comprised of unconsciousness, amnesia, analgesia and immobility with stability and control of vital physiological systems...
  34. Does Anesthetic Solubility Determine Receptor Specificity?
    ROBERT JOSEPH BROSNAN; Fiscal Year: 2013
    ..of a drug and the specificity of that drug for receptors that may mediate immobility and/or amnesia during general anesthesia. We have collected extensive preliminary data that suggest drug modulation of at least two anesthetic-..
  35. Frontoparietal Mechanisms of Anesthetic-induced Unconsciousness
    GEORGE ALEXANDER MASHOUR; Fiscal Year: 2013
    ..a leadership role in promoting patient safety, there is still no standard monitor for the target orga of general anesthesia: the brain...
  36. Neurodevelopment of Children Exposed to Anesthesia: A Population-Based Assessment
    David O Warner; Fiscal Year: 2013
    ..provided by applicant): Over one million young children are exposed to drugs used to induce and maintain general anesthesia each year in the United States...
  37. Neurophysiological Basis of General Anesthesia
    ALEXANDER PROEKT; Fiscal Year: 2013
    ..I analyzed electrocorticography recordings from human subjects and non-human primates during induction of general anesthesia. Stability analysis of these dynamics revealed that in the awake brain, cortical activity is tuned precisely ..
  38. Immunomodulatory mechanism of volatile anesthetics
    Koichi Yuki; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Volatile anesthetics are major drugs to provide general anesthesia during perioperative period...
  39. General Anesthetic Sites on Ligand-Gated Ion Channels
    Keith W Miller; Fiscal Year: 2013
    Some 25 million patients are given general anesthesia each year in the USA using agents with very low therapeutic indices. The molecular mechanisms of general anesthesia remain unknown, hampering the design of improved agents...
  40. Auditory Thalamic Implant
    STEVEN WAN CHEUNG; Fiscal Year: 2012
    ..intracranial devices to auditory structures accessible via infratentorial posterior fossa craniotomy under general anesthesia. Direct visual identification of the target auditory nucleus for implant placement is the dominant surgical ..
  41. Actuated Fine-Gauge Spinal Needle Insertion to Reduce Dura Damage and PDPH Risk
    MAUREEN L MULVIHILL; Fiscal Year: 2012
    ..Spinal anesthesia provides many benefits over general anesthesia including decreased blood loss, decreased post-anesthesia nausea and vomiting, and better post-op pain ..
  42. Effects of general vs. regional anesthesia on infant neurodevelopment and apnea
    Mary Ellen McCann; Fiscal Year: 2013
    ..provided by applicant): Each year large numbers of children undergo surgery involving exposure to general anesthesia. Whether such exposure increases a child's neurodevelopmental risk has never been established...
  43. Functional Cardiovascular 4D MRI in Congenital Heart Disease
    Cynthia K Rigsby; Fiscal Year: 2013
    ..radiation, and/or lengthy 60-90 minute Magnetic Resonance Imaging (MRI) exams, necessitating sedation or general anesthesia in pediatric patients...
  44. PBDE Body Burdens, House Dust Concentrations and Associations with Thyroid Hormon
    Lyndsey Darrow; Fiscal Year: 2012
    ..Serum samples will be obtained from a cohort of 80 children between 2 and 5 years of age who are under general anesthesia for ear tube surgery (myringotomy)...
  45. Volatile anesthetic alteration of neural precursor cell cycle and fate decisions
    Jeffrey W Sall; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Recent identification of long-term cognitive deficits following general anesthesia in neonatal animals has caused significant concern for clinical practice...
  46. Cellular Mechanisms of General Anesthetic Mediated Neurotoxicity
    Deborah J Culley; Fiscal Year: 2010
    b>General anesthesia is one of the great advances of medicine but is not without risks. Subtle central nervous toxicity may be one of them...
  47. Neglected By The Evidence: The Intersection of Medical Complexity and Dementia
    Lori A Daiello; Fiscal Year: 2013
    ..with dementia, 2) to determine the extent to which cognitively impaired individuals who receive isoflurane general anesthesia during hip fracture repair experience greater post-operative cognitive and functional decline in the year ..
  48. Catheter Dwell Time and Risk of Bloodstream Infections in Hospitalized Neonates
    Aaron M Milstone; Fiscal Year: 2011
    ..PICCs can be placed at the bedside without general anesthesia and can remain in place for days or weeks with seemingly minimal mechanical complications...
  49. Neurotoxic Effects of Volatile Anesthetics in C. elegans
    Philip G Morgan; Fiscal Year: 2012
    ..paradigm shift in the field of anesthesiology, in particular in regard to the care of infants undergoing general anesthesia. Volatile anesthetics have now been shown to cause apoptotic neuronal degeneration in developing rat brains...
  50. Active Induction of Emergence from General Anesthesia
    Ken Solt; Fiscal Year: 2013
    ..Plan: Accumulating evidence suggests that ascending arousal pathways in the brain promote emergence from general anesthesia (GA)...
  51. Volatile anesthetic effects on aging brain
    Zhiyi Zuo; Fiscal Year: 2013
    ..Most of them will have general anesthesia with volatile anesthetics as the primary anesthetics during surgery...
  52. Molecular interactions of general anesthetics in voltage-gated sodium channels
    ANNIKA FITZPATRICK BARBER; Fiscal Year: 2013
    Despite the ubiquitous use of general anesthetics, the molecular basis of general anesthesia has yet to be elucidated...
  53. Planning Parental/Motivational Interventions to Prevent Early Childhood Caries
    Mark Steven Wolff; Fiscal Year: 2013
    ..pain, and elevated risk for infection, emergency department visits, hospitalization, and treatment under general anesthesia (with its attendant risks and expense);(b) increased risk for future caries in primary and permanent teeth;(..
  54. General Anesthesia and Alzheimer's Disease Neuropathogenesis
    Zhongcong Xie; Fiscal Year: 2013
    ..In the proposed research we will further characterize these effects and determine their up-stream mechanisms and down-stream consequences. ..
  55. NMR STUDIES OF MECHANISMS OF GENERAL ANESTHESIA
    Yan Xu; Fiscal Year: 2013
    ..These new studies will eventually relate the structurally specific molecular events to the functional consequences of the action ofseneral anesthetics. ..
  56. Simultaneous Tc-99m-MDP/I-123-MIBG Imaging of Neuroblastoma Using SPECT-CT
    Jinsong Ouyang; Fiscal Year: 2011
    ..number of scans for each staging and re-staging because most of the children typically require sedation or general anesthesia during imaging...
  57. MAPPING ELOQUENT CORTEX USING RESTING STATE CORTICAL PHYSIOLOGY
    Joshua S Shimony; Fiscal Year: 2012
    ..be used in all patients, can be performed both pre- and intra-operatively, and can be used in the setting of general anesthesia. New approaches based on resting state cortical physiology, such as functional connectivity MRI (fcMRI) and ..
  58. ANESTHETIC MECHANISMS AND GABA-A RECEPTOR STRUCTURE
    MYLES AKABAS; Fiscal Year: 2001
    ..Many drugs used in the induction of general anesthesia, including benzodiazepines, volatile and intravenous anesthetics and barbiturates potentiate GABA-induced ..
  59. ANESTHETIC EFFECTS ON ION CHANNEL STRUCTURES &DYNAMICS
    Pei Tang; Fiscal Year: 2013
    ..of the anesthetic action on ion channels with the long-term goal of determining the molecular mechanism of general anesthesia. One of the important discoveries from our computational studies of the 1422 and 17 subtypes of nicotinic ..
  60. GENERAL ANESTHETICS AND CLONED VOLTAGE-GATED CHANNELS
    ANA CORREA; Fiscal Year: 2000
    b>General anesthesia is a condition in which loss of memory and consciousness is accompanied by loss of pain sensation...
  61. Tumor NMR Images are Affected by Anesthetic
    Natarajan Raghunand; Fiscal Year: 2006
    ..Inducing and maintaining general anesthesia can produce profound changes in normal physiology...
  62. Presurgery Hypnosis--Benefits Analysis in Breast Cancer
    Guy Montgomery; Fiscal Year: 2003
    ..Despite improvements in pharmacological management, surgical procedures under general anesthesia continue to be associated with clinically significant side effects, chief among which are pain and nausea...
  63. Dectection of occult mediastinal lymph node mestastases
    Michael Wallace; Fiscal Year: 2002
    ..nodes either lack sensitivity (computed tomography, positron emission tomography), or are invasive requiring general anesthesia (mediastinoscopy, thoracoscopy)...
  64. NonInvasive Optical Imaging of Vocal Cord Microstructure
    Brian Wong; Fiscal Year: 2004
    ..of many true vocal cord (TVC) lesions requires biopsy or excision which exposes the patient to the risks of general anesthesia, TVC injury, and potential iatrogenic glottic speech impairment...
  65. PREDICTORS OF POSTOPERATIVE ATELECTASIS PNEUMONIA
    JO BROOKS BRUNN; Fiscal Year: 2001
    ..and the target population is adults who are undergoing elective abdominal or cardiothoracic procedures with general anesthesia. The target sample size is 1500 subjects over a three year period...