anesthesia

Summary

Summary: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.

Top Publications

  1. ncbi Anesthesia in a patient with multiple endocrine abnormalities. Case report
    Renato Toledo Maciel
    Hospital Universitário Clementino Fraga Filho da Faculdade de Medicina da Universidade Federal do Rio de Janeiro HUCFF UFRJ, Rio de Janeiro, RJ
    Rev Bras Anestesiol 58:172-8. 2008
  2. ncbi Patients want an anesthesiologist to plan and be in charge of their anesthesia
    Alexander W Stricker
    J Clin Anesth 17:403-4. 2005
  3. ncbi Current practice of preoperative fasting: a nationwide survey in Japanese anesthesia-teaching hospitals
    Nobuaki Shime
    Department of Anesthesiology, Postgraduate School of Medicine, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto, 602-8566, Japan
    J Anesth 19:187-92. 2005
  4. ncbi MAC should stand for Maximum Anesthesia Caution, not Minimal Anesthesiology Care
    Carl C Hug
    Anesthesiology 104:221-3. 2006
  5. ncbi Anesthesia-related complications in living liver donors: the experience from one center and the reporting of one death
    S Ozkardesler
    Department of Anesthesiology and Reanimation, Medical Faculty of 9 Eylul University, Izmir, Turkey
    Am J Transplant 8:2106-10. 2008
  6. ncbi Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia
    Emmanuel Planel
    Columbia University Medical Center, Department of Pathology, Taub Institute for Alzheimer s Disease Research, New York, New York 10032, USA
    J Neurosci 27:3090-7. 2007
  7. ncbi Anesthesia for a patient with morbid obesity using dexmedetomidine without narcotics
    Roger E Hofer
    Department of Anesthesiology, Mayo Clinic College of Medicine, 200 First Street S.W, Rochester, MN 55905, USA
    Can J Anaesth 52:176-80. 2005
  8. ncbi Society for Ambulatory Anesthesia guidelines for the management of postoperative nausea and vomiting
    Tong J Gan
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesth Analg 105:1615-28, table of contents. 2007
  9. ncbi The incidence and nature of adverse events during pediatric sedation/anesthesia with propofol for procedures outside the operating room: a report from the Pediatric Sedation Research Consortium
    Joseph P Cravero
    Department of Anesthesiology and Pediatrics, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756 0001, USA
    Anesth Analg 108:795-804. 2009
  10. ncbi Anesthesia and the old brain
    Junxia Tang
    Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Anesth Analg 110:421-6. 2010

Research Grants

  1. Mechanisms of anesthetic effects on tachykinin induced airway tone
    Charles Emala; Fiscal Year: 2007
  2. Etomidate Analogues as Safer General Anesthetics
    Douglas E Raines; Fiscal Year: 2010
  3. Mechanisms of anesthetic effects on tachykinin induced airway tone
    Charles W Emala; Fiscal Year: 2010
  4. Neuromuscular blocker-induced asthma during anesthesia
    Charles Emala; Fiscal Year: 2006
  5. Outcomes After ACL Reconstruction: Femoral Nerve Block
    Brian Williams; Fiscal Year: 2005
  6. BRAIN METABOLISM DURING ANESTHESIA, LOW PH1, AND HYPOXIA
    Lawrence Litt; Fiscal Year: 1993
  7. The Role of the Amygdala in Anesthetic-Induced Amnesia
    MICHAEL ALKIRE; Fiscal Year: 2006
  8. Multimodal Functional Imaging of Auditory Perception Under General Anesthesia
    PATRICK PURDON; Fiscal Year: 2007
  9. Anesthesia-induced Developmental Neuroapoptosis
    Vesna Jevtovic Todorovic; Fiscal Year: 2007
  10. Anesthesia-induced Developmental Neuroapoptosis
    Vesna Jevtovic Todorovic; Fiscal Year: 2009

Detail Information

Publications278 found, 100 shown here

  1. ncbi Anesthesia in a patient with multiple endocrine abnormalities. Case report
    Renato Toledo Maciel
    Hospital Universitário Clementino Fraga Filho da Faculdade de Medicina da Universidade Federal do Rio de Janeiro HUCFF UFRJ, Rio de Janeiro, RJ
    Rev Bras Anestesiol 58:172-8. 2008
    ..The patient remained hemodynamically stable even during the pneumoperitoneum. She developed postoperative episodes of hypoglycemia, which motivated the re-operation...
  2. ncbi Patients want an anesthesiologist to plan and be in charge of their anesthesia
    Alexander W Stricker
    J Clin Anesth 17:403-4. 2005
  3. ncbi Current practice of preoperative fasting: a nationwide survey in Japanese anesthesia-teaching hospitals
    Nobuaki Shime
    Department of Anesthesiology, Postgraduate School of Medicine, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto, 602-8566, Japan
    J Anesth 19:187-92. 2005
    ..conducted a nationwide survey to investigate the current practice of the preoperative fasting period in Japanese anesthesia-teaching hospitals...
  4. ncbi MAC should stand for Maximum Anesthesia Caution, not Minimal Anesthesiology Care
    Carl C Hug
    Anesthesiology 104:221-3. 2006
  5. ncbi Anesthesia-related complications in living liver donors: the experience from one center and the reporting of one death
    S Ozkardesler
    Department of Anesthesiology and Reanimation, Medical Faculty of 9 Eylul University, Izmir, Turkey
    Am J Transplant 8:2106-10. 2008
    ..This procedure has some major risks related to anesthesia and surgery...
  6. ncbi Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia
    Emmanuel Planel
    Columbia University Medical Center, Department of Pathology, Taub Institute for Alzheimer s Disease Research, New York, New York 10032, USA
    J Neurosci 27:3090-7. 2007
    Postoperative cognitive dysfunction, confusion, and delirium are common after general anesthesia in the elderly, with symptoms persisting for months or years in some patients...
  7. ncbi Anesthesia for a patient with morbid obesity using dexmedetomidine without narcotics
    Roger E Hofer
    Department of Anesthesiology, Mayo Clinic College of Medicine, 200 First Street S.W, Rochester, MN 55905, USA
    Can J Anaesth 52:176-80. 2005
    ..7 microg.kg(-1).hr(-1)). The anesthesia course was uneventful, and the intraoperative use of dexmedetomidine was associated with low anesthetic ..
  8. ncbi Society for Ambulatory Anesthesia guidelines for the management of postoperative nausea and vomiting
    Tong J Gan
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesth Analg 105:1615-28, table of contents. 2007
    ..and expertise in postoperative nausea and vomiting (PONV) under the auspices of The Society of Ambulatory Anesthesia. The panel critically evaluated the current medical literature on PONV to provide an evidence-based reference ..
  9. ncbi The incidence and nature of adverse events during pediatric sedation/anesthesia with propofol for procedures outside the operating room: a report from the Pediatric Sedation Research Consortium
    Joseph P Cravero
    Department of Anesthesiology and Pediatrics, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756 0001, USA
    Anesth Analg 108:795-804. 2009
    We used a large database of prospectively collected data on pediatric sedation/anesthesia outside the operating room provided by a wide range of pediatric specialists to delineate the nature and frequency of adverse events associated with ..
  10. ncbi Anesthesia and the old brain
    Junxia Tang
    Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Anesth Analg 110:421-6. 2010
    ..In this special article, we summarize the rationale and evidence that the anesthetic per se is a contributor. The evidence at this point is considered suggestive and further research is needed, especially in humans...
  11. ncbi Update on tracheobronchial anatomy and flexible fiberoptic bronchoscopy in thoracic anesthesia
    Javier H Campos
    Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
    Curr Opin Anaesthesiol 22:4-10. 2009
    This review is focused on tracheobronchial anatomy and the use of flexible fiberoptic bronchoscopy in thoracic anesthesia.
  12. ncbi Cyclic and sleep-like spontaneous alternations of brain state under urethane anaesthesia
    Elizabeth A Clement
    Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 3:e2004. 2008
    ....
  13. ncbi Human Alzheimer and inflammation biomarkers after anesthesia and surgery
    Junxia X Tang
    Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Anesthesiology 115:727-32. 2011
    ..The authors studied human cerebrospinal fluid (CSF) biomarkers during surgery...
  14. ncbi Less core hypothermia when anesthesia is induced with inhaled sevoflurane than with intravenous propofol
    T Ikeda
    Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Japan
    Anesth Analg 88:921-4. 1999
    Hypothermia after the induction of anesthesia results initially from core-to-peripheral redistribution of body heat. Sevoflurane and propofol both inhibit central thermoregulatory control, thus causing vasodilation...
  15. ncbi Population imaging of ongoing neuronal activity in the visual cortex of awake rats
    David S Greenberg
    Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
    Nat Neurosci 11:749-51. 2008
    ..b>Anesthesia modulated population-wide synchronization and the relationship between firing rate and correlation...
  16. ncbi Stimulus onset quenches neural variability: a widespread cortical phenomenon
    Mark M Churchland
    Department of Electrical Engineering, Stanford University School of Medicine, Stanford University, Stanford, California, USA
    Nat Neurosci 13:369-78. 2010
    ..This widespread variability decline suggests a rather general property of cortex, that its state is stabilized by an input...
  17. ncbi Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis
    Annette Robichaud
    Merck Frosst Centre for Therapeutic Research, Pointe Claire Dorval, Quebec, Canada
    J Clin Invest 110:1045-52. 2002
    ..of type 4 cAMP-specific cyclic nucleotide phosphodiesterase 4 (PDE4) in reversing alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis in non-vomiting species...
  18. ncbi Prevention and treatment of postoperative nausea and vomiting
    A L Kovac
    Department of Anaesthesiology, University of Kansas Medical Center, Kansas City 66160 7415, USA
    Drugs 59:213-43. 2000
    ....
  19. ncbi Bispectral index-guided administration of anesthesia for transsphenoidal resection of pituitary tumors: a comparison of 3 anesthetic techniques
    Zulfiqar Ali
    Department of Neuroanaesthesiology, Neurosciences Center, All India Institute of Medical Sciences, New Delhi, India
    J Neurosurg Anesthesiol 21:10-5. 2009
    The main aims of anesthesia for pituitary surgery include maintenance of hemodynamic stability, provision of conditions that facilitate surgical exposure, and a smooth emergence to facilitate a prompt neurologic assessment...
  20. ncbi Redesigning a morbidity and mortality program in a university-affiliated pediatric anesthesia department
    Conor McDonnell
    Department of Anesthesia and Pain Medicine, The Hospital for Sick Children, Toronto
    Jt Comm J Qual Patient Saf 36:117-25. 2010
    ..The M&M activities were developed in a university-affiliated pediatric anesthesia department as part of a departmental quality improvement (QI) initiative...
  21. ncbi Microcirculatory alterations in cardiac surgery: effects of cardiopulmonary bypass and anesthesia
    Daniel De Backer
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Ann Thorac Surg 88:1396-403. 2009
    ..Heterogeneity in microvascular perfusion is associated with impaired tissue oxygenation. We hypothesized that cardiac surgery with or without cardiopulmonary bypass (CPB) could induce microvascular alterations...
  22. ncbi Safety and efficacy of various combinations of injectable anesthetics in BALB/c mice
    Sandra Buitrago
    Department of Laboratory Animal Resources, Roswell Park Cancer Institute, Buffalo, NY, USA
    J Am Assoc Lab Anim Sci 47:11-7. 2008
    ..ketamine-xylazine-buprenorphine, and ketamine-xylazine-carprofen--were compared for their ability to produce anesthesia in BALB/c mice...
  23. ncbi Low degree of anesthesia increases the risk of neurogenic pulmonary edema development
    J Sedy
    Institute of Experimental Medicine, ASCR, Prague, Czech Republic
    Med Hypotheses 70:308-13. 2008
    ..We introduce a new hypothesis that high levels of anesthesia might protect the organism against the development of neurogenic pulmonary edema due to a more pronounced ..
  24. ncbi Anesthesia for thoracic surgery in morbidly obese patients
    Jens Lohser
    Department of Anesthesiology, Stanford University School of Medicine, Stanford, California, USA
    Curr Opin Anaesthesiol 20:10-4. 2007
    ..Obese patients have altered anatomy and physiology, and usually have associated comorbid medical conditions that may complicate their operative course and increase their risks for postoperative complications...
  25. ncbi Signaling at A-kinase anchoring proteins organizes anesthesia-sensitive memory in Drosophila
    Martin Schwaerzel
    Saarland University, Faculty 8 3 Life Science, Department of Zoology and Physiology, 66041 Saarbrucken, Germany
    J Neurosci 27:1229-33. 2007
    ..Together, our results show that subcellular organization of signaling components plays a key role in memory processing...
  26. ncbi Bruchpilot, a synaptic active zone protein for anesthesia-resistant memory
    Stephan Knapek
    Max Planck Institut fur Neurobiologie, 82152 Martinsried, Germany
    J Neurosci 31:3453-8. 2011
    ..We further demonstrate that Brp in the Kenyon cells preferentially functions for anesthesia-resistant memory...
  27. ncbi Propofol anesthesia and sleep: a high-density EEG study
    Michael Murphy
    Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
    Sleep 34:283-91A. 2011
    ..We used high-density electroencephalography (hd-EEG) and source modeling to investigate the cortical processes underlying propofol anesthesia and compare them to sleep.
  28. ncbi A protocol for use of medetomidine anesthesia in rats for extended studies using task-induced BOLD contrast and resting-state functional connectivity
    Christopher P Pawela
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Neuroimage 46:1137-47. 2009
    ..In the secondary infusion period using 300 microg/kg/h, resting-state functional connectivity is enhanced...
  29. ncbi Temporal scaling properties and spatial synchronization of spontaneous blood oxygenation level-dependent (BOLD) signal fluctuations in rat sensorimotor network at different levels of isoflurane anesthesia
    Kun Wang
    LIAMA Center for Computational Medicine, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China
    NMR Biomed 24:61-7. 2011
    ..In order to obtain more insights into this relationship and, in particular, the effects of anesthesia thereupon, we investigated the spatial and temporal correlations of spontaneous BOLD fluctuations in ..
  30. ncbi The effects of sevoflurane and desflurane anesthesia on QTc interval and cardiac rhythm in children
    Ebru Aypar
    Section of Pediatric Cardiology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Paediatr Anaesth 17:563-7. 2007
    ..We assessed the effects of desflurane anesthesia on QTc interval and cardiac rhythm and compared them with sevoflurane anesthesia in children.
  31. ncbi Impact of anesthesia on transcranial electric motor evoked potential monitoring during spine surgery: a review of the literature
    Anthony C Wang
    Department of Neurosurgery, University of Michigan Health System, Ann Arbor, Michigan 48109 5338, USA
    Neurosurg Focus 27:E7. 2009
    ..b>Anesthesia, however, can significantly affect the reliability of TcMEP monitoring...
  32. ncbi Oxygen in neonatal anesthesia: friend or foe?
    Augusto Sola
    Mid Atlantic Neonatology Associates and Atlantic Neonatal Research Institute, Morristown, NJ 07960, USA
    Curr Opin Anaesthesiol 21:332-9. 2008
    ..Hypoxemia is due to many pathophysiological causes; avoiding hypoxemia is an important objective during neonatal anesthesia. Nevertheless, the only known cause for hyperoxemia is the excess and unnecessary administration of oxygen by ..
  33. ncbi Use of in-office anesthesia during non-surgical radiofrequency collagen denaturation for stress urinary incontinence
    W Glen Wells
    Alabama Research Center, Birmingham, AL 35209, USA
    Curr Med Res Opin 23:1279-84. 2007
    ..This multicenter trial aimed to demonstrate the feasibility, safety, and efficacy of an oral sedation and local anesthetic regimen in performing RF collagen denaturation...
  34. ncbi The effects of carbon dioxide anesthesia and anoxia on rapid cold-hardening and chill coma recovery in Drosophila melanogaster
    Theresa L Nilson
    Department of Biological Sciences University of Nevada, Las Vegas, NV 89154-4004, USA
    J Insect Physiol 52:1027-33. 2006
    ..Exposure to CO(2) anesthesia increases chill coma recovery time, but this effect disappears if the flies are given 90 min recovery in air ..
  35. ncbi Anaphylaxis during anesthesia in Norway: a 6-year single-center follow-up study
    Torkel Harboe
    Department of Anesthesia and Intensive Care, Haukeland University Hospital, Bergen, Norway
    Anesthesiology 102:897-903. 2005
    ..studies have recognized neuromuscular blocking agents as the most common cause of anaphylaxis during general anesthesia, but the reported frequencies vary considerably between countries...
  36. ncbi Contralateral hand anesthesia transiently improves poststroke sensory deficits
    Bernhard Voller
    Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Ann Neurol 59:385-8. 2006
    ..RESULTS: We found that sensibility in the affected hand improved with intact hand anesthesia, but not with intact foot anesthesia or no anesthesia...
  37. ncbi Brain-state- and cell-type-specific firing of hippocampal interneurons in vivo
    Thomas Klausberger
    MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, Oxford University, Mansfield Road, Oxford OX1 3TH, UK
    Nature 421:844-8. 2003
    ..We conclude that the diversity of interneurons, innervating distinct domains of pyramidal cells, emerged to coordinate the activity of pyramidal cells in a temporally distinct and brain-state-dependent manner...
  38. ncbi Educating patients about anesthesia: a systematic review of randomized controlled trials of media-based interventions
    Anna Lee
    Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, China
    Anesth Analg 96:1424-31, table of contents. 2003
    In this systematic review, we compared the effectiveness of media-based patient education about anesthesia. Fifteen randomized controlled trials (n = 1506) were identified after a systematic search of electronic databases (MEDLINE, EMBASE,..
  39. ncbi Trends in anesthesia-related death and brain damage: A closed claims analysis
    Frederick W Cheney
    Department of Anesthesiology, University of Washington, School of Medicine, Seattle, WA 98195 6540, USA
    Anesthesiology 105:1081-6. 2006
    ....
  40. ncbi Integration and segregation of activity in entorhinal-hippocampal subregions by neocortical slow oscillations
    Yoshikazu Isomura
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, New Jersey 07102, USA
    Neuron 52:871-82. 2006
    ..Thus, neo/paleocortical and hippocampal networks periodically reset, self-organize, and temporally coordinate their cell assemblies via the slow oscillation...
  41. ncbi The effects of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam on arterial blood pH, blood gases, mean arterial blood pressure and heart rate in adult male rats
    S K Wixson
    Department of Comparative Medicine, Milton S Hershey Medical Center, Pennsylvania State University, Hershey 17033
    Lab Anim Sci 37:736-42. 1987
    ..Throughout all dosages investigated, the ketamine-diazepam combination showed the least overall effects on ventilation and perfusion of the four parenteral drug combinations studied...
  42. ncbi Percutaneous and minimally invasive valve procedures: a scientific statement from the American Heart Association Council on Cardiovascular Surgery and Anesthesia, Council on Clinical Cardiology, Functional Genomics and Translational Biology Interdisciplin
    Todd K Rosengart
    State University of New York Stony Brook, USA
    Circulation 117:1750-67. 2008
    ....
  43. ncbi Anesthetic management and one-year mortality after noncardiac surgery
    Terri G Monk
    Department of Anesthesiology Duke University Medical Center, Durham, NC 27705, USA
    Anesth Analg 100:4-10. 2005
    ..We designed a prospective observational study of adult patients undergoing major noncardiac surgery with general anesthesia to determine if mortality in the first year after surgery is associated with demographic, preoperative clinical, ..
  44. ncbi Cellular and network mechanisms of slow oscillatory activity (<1 Hz) and wave propagations in a cortical network model
    Albert Compte
    Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurophysiol 89:2707-25. 2003
    Slow oscillatory activity (<1 Hz) is observed in vivo in the cortex during slow-wave sleep or under anesthesia and in vitro when the bath solution is chosen to more closely mimic cerebrospinal fluid...
  45. ncbi Development of a measure of patient satisfaction with monitored anesthesia care: the Iowa Satisfaction with Anesthesia Scale
    F Dexter
    Department of Anesthesia, University of Iowa, Iowa City 52242, USA
    Anesthesiology 87:865-73. 1997
    The authors describe development of the Iowa Satisfaction with Anesthesia Scale (ISAS) for monitored anesthesia care (MAC). Patients complete the self-administered written questionnaire before discharge from the hospital...
  46. ncbi Distress during the induction of anesthesia and postoperative behavioral outcomes
    Z N Kain
    Department of Anesthesiology, Yale School of Medicine, New Haven, Connecticut, USA
    Anesth Analg 88:1042-7. 1999
    We determined whether children who are extremely anxious during the induction of anesthesia are more at risk of developing postoperative negative behavioral changes compared with children who appear calm during the induction process...
  47. ncbi Anesthesia for electroconvulsive therapy
    Zhengnian Ding
    Department of Anesthesiology and Pain Management, First Affiliated Hospital of Nanjing Medical University, China
    Anesth Analg 94:1351-64. 2002
  48. ncbi Muscle relaxation does not alter hypnotic level during propofol anesthesia
    Robert Greif
    Department of Anesthesiology and Intensive Care Medicine, Donauspital-SMZO, Vienna, Austria
    Anesth Analg 94:604-8; table of contents. 2002
    ..BIS averaged 95 plus/minus 4 before induction of anesthesia, and decreased significantly to 40 plus/minus 5 after propofol administration...
  49. ncbi Anesthesia-related cardiac arrest in children: update from the Pediatric Perioperative Cardiac Arrest Registry
    Sanjay M Bhananker
    Department of Anesthesiology, University of Washington School of Medicine, Seattle, WA, USA
    Anesth Analg 105:344-50. 2007
    ..Changes in pediatric anesthesia practice may have altered the causes of cardiac arrest in anesthetized children.
  50. ncbi Fatal and non fatal cardiac arrests related to anesthesia
    P Biboulet
    Department of Anesthesiology and Critical Care A, Lapeyronie University Hospital, Montpellier, France
    Can J Anaesth 48:326-32. 2001
    The aim of this study was to assess the incidence and causes of cardiac arrests related to anesthesia.
  51. ncbi A retrospective cohort study of the association of anesthesia and hernia repair surgery with behavioral and developmental disorders in young children
    Charles DiMaggio
    Department of Epidemiology, Mailman School of Public Health, New York, NY, USA
    J Neurosurg Anesthesiol 21:286-91. 2009
    ..of the potential association of surgery and its concurrent exposure to anesthetic agents with neurotoxicity and underscore the need for more rigorous clinical research on the long-term effects of surgery and anesthesia in children.
  52. ncbi Plasma concentrations of neuroactive steroids before and after electroconvulsive therapy in major depression
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University of Munich, Munich, Germany
    Neuropsychopharmacology 30:1181-6. 2005
    ....
  53. ncbi Injury and liability associated with monitored anesthesia care: a closed claims analysis
    Sanjay M Bhananker
    Department of Anesthesiology, University of Washington, Virginia Mason Medical Center, Seattle, WA 98195, USA
    Anesthesiology 104:228-34. 2006
    To assess the patterns of injury and liability associated with monitored anesthesia care (MAC) compared with general and regional anesthesia, the authors reviewed closed malpractice claims in the American Society of Anesthesiologists ..
  54. ncbi Exposure to anaesthetic agents, cognitive functioning and depressive symptomatology in the elderly
    M L Ancelin
    INSERM EPI-9930, Epidemiology and Clinical Research in Nervous System Pathologies, CLRC Val d'Aurelle, Bat. Rech. Rdc, , 34298 Montpellier Cedex 5, France
    Br J Psychiatry 178:360-6. 2001
    ..CONCLUSIONS: Cognitive functions are not equally affected, type of impairment being determined by the risk factors described above and anaesthesia type...
  55. ncbi Anesthesia suppresses nonsynchronous responses to repetitive broadband stimuli
    R L Rennaker
    University of Oklahoma, 865 Asp Avenue, Felgar Hall 210, Norman, OK 73019, USA
    Neuroscience 145:357-69. 2007
    ..To investigate the effects of anesthesia on temporal processing in rat auditory cortex, multi-unit neural responses to trains of broadband clicks were ..
  56. ncbi Anesthesia for awake craniotomy: a retrospective study
    Prabhat Kumar Sinha
    Department of Anesthesiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India
    Neurol India 55:376-81. 2007
    ..Awake craniotomy is increasingly performed the world over. We share our experience of performing craniotomy awake with our anesthetic protocol...
  57. ncbi Pharmacokinetic-pharmacodynamic modeling in anesthesia, intensive care and pain medicine
    Mihai R Sadean
    Department of Anesthesiology, SUNY at Stony Brook, Stony Brook, New York, USA
    Curr Opin Anaesthesiol 22:463-8. 2009
    ..Studies from the anesthesiology literature published in the last 2 years were selected to illustrate the most important developments in the field of pharmacokinetic-pharmacodynamic modeling...
  58. ncbi Epidemiology of anesthesia-related mortality in the United States, 1999-2005
    Guohua Li
    Center for Health Policy and Outcomes in Anesthesia and Critical Care, Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Anesthesiology 110:759-65. 2009
    Previous research on anesthesia-related mortality in the United States was limited to data from individual hospitals. The purpose of this study was to examine the epidemiologic patterns of anesthesia-related deaths at the national level.
  59. ncbi Arterial blood pressure and heart rate discrepancies between handwritten and computerized anesthesia records
    D L Reich
    Departments of Anesthesiology and Biomathematical Sciences, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Anesth Analg 91:612-6. 2000
    Previous publications suggest that handwritten anesthesia records are less accurate when compared with computer-generated records, but these studies were limited by small sample size, unblinded study design, and unpaired statistical ..
  60. ncbi Anesthesia-related cardiac arrest in children: the Thai Anesthesia Incidents Study (THAI Study)
    Nutchanart Bunchungmongkol
    Department of Anesthesiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
    J Med Assoc Thai 92:523-30. 2009
    The Thai Anesthesia Incidents study (THAI Study) is the first national study of anesthesia outcomes during anesthesia practice in Thailand...
  61. ncbi Pediatric sedation/anesthesia outside the operating room
    David Gozal
    Department of Anesthesiology and Critical Care Medicine, Hadassah University Hospital, Israel
    Curr Opin Anaesthesiol 21:494-8. 2008
    The demand of procedures performed on children outside the operating room setting often exceeds the capacity of anesthesia services...
  62. ncbi The entwined mysteries of anesthesia and consciousness: is there a common underlying mechanism?
    Stuart R Hameroff
    Department of Anesthesiology, The University of Arizona, Tucson, Arizona 85718, USA
    Anesthesiology 105:400-12. 2006
  63. ncbi Update on anesthesia considerations for electroconvulsive therapy
    Cody Mayo
    Department of Internal Medicine, Methodist Hospital, Houston, Texas, USA
    Middle East J Anesthesiol 20:493-8. 2010
    ..ECT is a proven therapy for select psychiatric patients, and appropriate anesthesia is a critical part of successful ECT...
  64. ncbi Ambulatory anesthesia and regional catheters: when and how
    Jeffrey D Swenson
    Department of Anesthesiology, University of Utah Orthopaedics Hospital, University of Utah, Salt Lake City, UT 84132, USA
    Anesthesiol Clin 28:267-80. 2010
    ..Techniques for catheter placement, infusion regimens, patient education, and complications are subject to many institutional preferences. In this review, special emphasis is placed on evidence-based techniques...
  65. ncbi Intracortical microcirculatory change induced by anesthesia in rat somatosensory cortex
    Kazuto Masamoto
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    Adv Exp Med Biol 662:57-61. 2010
    The present study aimed to characterize microcirculatory responses to anesthesia in brain tissue...
  66. ncbi Anesthesia for patients with a history of malignant hyperthermia
    Frank Wappler
    University Witten Herdecke, Department of Anaesthesiology and Intensive Care Medicine, Department of Paediatric Anaesthesia, Clinics of Cologne, Cologne, Germany
    Curr Opin Anaesthesiol 23:417-22. 2010
    ..The aim of this review is to present current knowledge about pathophysiology and triggers of malignant hyperthermia as well as concepts for safe anaesthesiological management of these patients...
  67. ncbi Long-term post-operative cognitive decline in the elderly: the effects of anesthesia type, apolipoprotein E genotype, and clinical antecedents
    Marie Laure Ancelin
    INSERM, Montpellier, France
    J Alzheimers Dis 22:105-13. 2010
    Cognitive dysfunction in the elderly commonly observed following anesthesia has been attributed to age-related neuronal changes exacerbated by pharmacotoxic effects...
  68. ncbi Effect of anesthetic technique on serum vascular endothelial growth factor C and transforming growth factor β in women undergoing anesthesia and surgery for breast cancer
    Micheal Looney
    Department of Anaesthesia, Mater Misericordiae University Hospital, Dublin, Ireland
    Anesthesiology 113:1118-25. 2010
    ..anesthetic (PPA) technique would attenuate postoperative changes in these angiogenic factors to a greater extent than balanced general anesthesia (GA) and morphine analgesia in women undergoing surgery for primary breast cancer.
  69. ncbi Moyamoya disease and anesthesia
    Nigar Baykan
    Department of Anaesthesia, Ozel Acibadem Hospital, Istanbul, Turkey
    Paediatr Anaesth 15:1111-5. 2005
    ..This report presents three cases of Moyamoya disease in patients under 3 years of age, and discusses anesthesia management issues for pediatric patients with this condition.
  70. ncbi Deep sedation and minimal anesthesia
    Michael R J Sury
    Department of Anaesthesia, Great Ormond Street Hospital for Children, NHS Trust, London, UK
    Paediatr Anaesth 18:18-24. 2008
  71. ncbi Anesthesia for functional neurosurgery: review of complications
    Lakshmi Venkatraghavan
    Department of Anesthesia, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Neurosurg Anesthesiol 18:64-7. 2006
    ..underwent an ablative procedure (n = 6) or the insertion of deep brain stimulator (n = 172) under monitored anesthesia care for movement disorders (n = 124), chronic pain (n = 20), and other procedures (n = 34)...
  72. ncbi The effects of the type of anesthesia on outcomes of lower extremity infrainguinal bypass
    Niten Singh
    VA Medical Center, Washington, DC, USA
    J Vasc Surg 44:964-8; discussion 968-70. 2006
    OBJECTIVE: Three main types of anesthesia are used for infrainguinal bypass: general endotracheal anesthesia (GETA), spinal anesthesia (SA), and epidural anesthesia (EA)...
  73. ncbi Anesthesia in the patient with multiple drug allergies: are all allergies the same?
    Pascale Dewachter
    Pôle d Anesthésie Réanimation, Hopital Gabriel Montpied, Clermont Ferrand, France
    Curr Opin Anaesthesiol 24:320-5. 2011
    ..The aim of this review is to facilitate the recognition of risk factors for perioperative anaphylaxis and help the management of patients with 'multiple drug allergies' during the perioperative period...
  74. ncbi The Drosophila radish gene encodes a protein required for anesthesia-resistant memory
    Elisabeth Folkers
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 103:17496-500. 2006
    Long-term memory in Drosophila is separable into two components: consolidated, anesthesia-resistant memory and long-lasting, protein-synthesis-dependent memory...
  75. ncbi Lidocaine pretreatment for the prevention of propofol-induced transient motor disturbances in children during anesthesia induction: a randomized controlled trial in children undergoing invasive hematologic procedures
    Federico Bilotta
    Department of Anesthesiology, Intensive Care and Pain Medicine, University of Rome La Sapienza, Rome, Italy
    Paediatr Anaesth 16:1232-7. 2006
    ..before propofol administration on the incidence of transient motor disturbances and on propofol requirements for anesthesia induction in infants and children undergoing repeated painful diagnostic and therapeutic hematological procedures...
  76. ncbi Telemedicine in anesthesia: an update
    Jorge A Galvez
    Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, and Department of Critical Care Medicine and Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19106, USA
    Curr Opin Anaesthesiol 24:459-62. 2011
    ..Increasing economic pressures on healthcare delivery systems make initiatives such as telemedicine, which reduce costs while achieving excellent outcomes, an attractive option...
  77. ncbi Response to neonatal anesthesia: effect of sex on anatomical and behavioral outcome
    S Rothstein
    Neuroscience Program and Department of Psychology, Michigan State University, 138 Giltner Hall, East Lansing, MI 48824, USA
    Neuroscience 152:959-69. 2008
    Numerous studies have documented the consequences of exposure to anesthesia in models of term and post-term infants, evaluating the incidence of cell loss, physiological alterations and cognitive dysfunction...
  78. ncbi Anesthesia and hemoglobinopathies
    Paul G Firth
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02114, USA
    Anesthesiol Clin 27:321-36. 2009
    ..This article reviews the common types of hemoglobinopathies, presents a basic summary of the pathophysiology relevant to anesthesia, and outlines current perioperative management.
  79. ncbi Calculating institutional support that benefits both the anesthesia group and hospital
    Franklin Dexter
    Division of Management Consulting, Department of Anesthesia, University of Iowa, Iowa City, IA 52242, USA
    Anesth Analg 106:544-53, table of contents. 2008
    Institutional support to anesthesia groups for clinical care is very common, particularly when compensation for certified registered nurse anesthetists and anesthesiology residents is considered...
  80. ncbi Clinical assessment of a new anaesthetic drug administration system: a prospective, controlled, longitudinal incident monitoring study
    C S Webster
    Centre for Medical and Health Sciences Education, Department of Anaesthesiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Anaesthesia 65:490-9. 2010
    ..006-0.028%). No major adverse outcomes from these errors were reported with the new system while 11 (0.002%) were reported with conventional methods (p = 0.055). We conclude that targeted system re-design can reduce medical error...
  81. ncbi Mortality in anesthesia: a systematic review
    Leandro Gobbo Braz
    Department of Anesthesiology, Botucatu Medical School, Sao Paulo State University UNESP, Sao Paulo, SP, Brazil
    Clinics (Sao Paulo) 64:999-1006. 2009
    ..review of the Brazilian and worldwide literature aims to evaluate the incidence and causes of perioperative and anesthesia-related mortality...
  82. ncbi Sevoflurane anesthesia decreases cardiac vagal activity and heart rate variability
    Chanannait Paisansathan
    Anesthesiology Department, University of Illinois at Chicago, 1740 W Taylor, Suite 3200, Chicago, IL 60612, USA
    Clin Auton Res 17:370-4. 2007
    We evaluated cardiac vagal activity during sevoflurane anesthesia in neurosurgical patients. Heart rate variability was determined by power spectral analysis and entropy with the patient awake and during sevoflurane anesthesia...
  83. ncbi Confounding effects of volatile anesthesia on CBV assessment in rodent forebrain following ethanol challenge
    Feng Luo
    Experimental Imaging Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Magn Reson Imaging 26:557-63. 2007
    ..To compare and contrast the pattern and characteristics of the cerebral blood volume (CBV) response to ethanol (EtOH) in rats under awake and anesthetized conditions...
  84. ncbi Effects of intramuscular anesthesia on the expression of primary and referred pain induced by intramuscular injection of hypertonic saline
    Troy K Rubin
    Prince of Wales Medical Research Institute, Sydney NSW, Australia
    J Pain 10:829-35. 2009
    ..We conclude that the maintenance of referred muscle pain usually depends on ongoing noxious inputs from the site of primary muscle pain...
  85. ncbi An evidence-based review of parental presence during anesthesia induction and parent/child anxiety
    Josie Chundamala
    Department of Surgery, The Hospital for Sick Children, 555 University Avenue, Room 1218, Black Wing, Toronto, ON, Canada M5G 1X8
    Can J Anaesth 56:57-70. 2009
    The purpose of this evidence-based review was to examine the effect of parental presence during anesthesia induction on parents' and children's anxiety.
  86. ncbi Newer anesthesia and rehabilitation protocols enable outpatient hip replacement in selected patients
    Richard A Berger
    Department of Orthopaedic Surgery, Rush Medical College, Rush Presbyterian St Luke s Medical Center, 1725 West Harrison Street, Suite 1063, Chicago, IL 60612, USA
    Clin Orthop Relat Res 467:1424-30. 2009
    ..A comprehensive perioperative anesthesia and rehabilitation protocol including preoperative teaching, regional anesthesia, and preemptive oral analgesia ..
  87. ncbi A neuro-fuzzy approach for predicting hemodynamic responses during anesthesia
    Catarina S Nunes
    Division of Engineering, King s College London, Strand, London, WC2R 2LS, United Kingdom
    Conf Proc IEEE Eng Med Biol Soc 2008:5814-7. 2008
    ..It is also important for control infusion systems during anesthesia. In this article, an adaptive-network fuzzy inference system is used to model the effect of two drugs (propofol ..
  88. ncbi Orexin A decreases ketamine-induced anesthesia time in the rat: the relevance to brain noradrenergic neuronal activity
    Ryuji Tose
    Department of Anesthesiology, Institute of Brain Science, University of Hirosaki School of Medicine, Hirosaki, Japan
    Anesth Analg 108:491-5. 2009
    ..Ketamine increases NE release from the rat cerebral cortex. We hypothesized that OX would affect ketamine anesthesia's interactions with brain noradrenergic neuronal activity.
  89. ncbi Preoperative melatonin and its effects on induction and emergence in children undergoing anesthesia and surgery
    Zeev N Kain
    Department of Anesthesiology, University of California, Irvine School of Medicine, Irvine, California, USA
    Anesthesiology 111:44-9. 2009
    Studies conducted in adults undergoing surgery reported a beneficial effect of oral melatonin administered before surgery. There is a paucity of such data in children undergoing anesthesia and surgery.
  90. ncbi [Respiratory sinus arrhythmia as predictor of blood pressure stability during anaesthetic induction in diabetics]
    D Knüttgen
    Lehrstuhl für Anästhesiologie II der Universität Witten Herdecke, Klinik fur Anasthesiologie und Operative Intensivmedizin, Kliniken der Stadt Köln gGmbH, Krankenhaus Merheim, Koln
    Anasthesiol Intensivmed Notfallmed Schmerzther 41:233-40. 2006
    ..The aim of this study was to evaluate whether patients at risk could be reliably identified with less diagnostic effort...
  91. ncbi Comparison of xenon with propofol for supplementary general anaesthesia for knee replacement: a randomized study
    L S Rasmussen
    Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Br J Anaesth 97:154-9. 2006
    ..The aim of this study was to compare xenon with propofol for supplementary general anaesthesia in patients undergoing knee replacement in spinal anaesthesia...
  92. ncbi Cerebral state monitor, a new small handheld EEG monitor for determining depth of anaesthesia: a clinical comparison with the bispectral index during day-surgery
    R E Anderson
    Department of Cardiothoracic Anaesthetics and Intensive Care, Karolinska Hospital, Stockholm, Sweden
    Eur J Anaesthesiol 23:208-12. 2006
    ..Which monitor is the more dependable remains to be established and cannot be implied from this initial explorative study...
  93. ncbi Cerebrovascular reactivity to carbon dioxide in the normal and abnormal cerebral hemispheres under anesthesia in patients with frontotemporal gliomas
    Ganne S Umamaheswara Rao
    National Institute of Mental Health and Neurosciences, Bangalore
    J Neurosurg Anesthesiol 18:185-8. 2006
    ..reactivity to CO2 in the cerebral hemispheres with and without tumors under intravenous and inhalational anesthesia. Twenty-nine patients undergoing craniotomy for frontotemporal gliomas were randomized to receive intravenous ..
  94. ncbi Haemodynamic and Bispectral index response to insertion of the Streamlined Liner of the Pharynx Airway (SLIPA): comparison with the laryngeal mask airway
    G D Puri
    Department of Anaesthesia and Intensive Care, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Anaesth Intensive Care 36:404-10. 2008
    ..001) incidence of blood on the device with the SLIPA (20/50 vs. 6/50 with LMA). Thus, insertion of SLIPA causes significantly higher blood-pressure response but similar BIS response compared to the LMA...
  95. ncbi [Detection of intraoperative awareness via auditory evoked potentials in an infant]
    M S Feuerecker
    , , Marchioninistr. 15,
    Anaesthesist 55:1058-63. 2006
    ..Exemplarily this case suggests that MLAEPs could be used to detect intraoperative awareness also in paediatric anaesthesia. Investigations to prove the validity and reproducibility of MLAEPs in children will be necessary...
  96. ncbi Both clonidine and metoprolol modify anesthetic depth indicators and reduce intraoperative propofol requirement
    Indranil Ghosh
    Department of Neuroanesthesiology, CN Center, All India Institute of Medical Sciences, New Delhi, India
    J Anesth 22:131-4. 2008
    Beta-blockers have been used in the past to decrease the depth of anesthesia, but the results are conflicting. However, beta-blockers are known to suppress electroencephalographic activities...
  97. ncbi Anesthesia for orthopedic surgery in Pallister-Killian syndrome
    Jana Knab
    Paediatr Anaesth 18:682-4. 2008
  98. ncbi Anaesthesia for abdominal aneurysm repair in a patient with Guillain-Barré Syndrome
    H Y Yousif
    Anaesth Intensive Care 35:310-1. 2007
  99. ncbi The role of monitoring the depth of anesthesia in a case of hereditary sensory and autonomic neuropathy (Riley Day syndrome)
    Sanjib Das Adhikary
    Paediatr Anaesth 17:402-3; author reply 403. 2007
  100. ncbi Anaesthesia for off-pump coronary artery surgery
    Sanjula Virmani
    Department of Anaesthesiology and Intensive Care, G.B. Pant Hospital, New Delhi
    Ann Card Anaesth 10:65-71. 2007
  101. ncbi Propofol and remifentanil for deep sedation in children undergoing gastrointestinal endoscopy
    Ibrahim Abu-Shahwan
    Department of Anesthesiology, Children s Hospital of Eastern Ontario, 401 Smyth Rd, University of Ottawa, Ottawa, ON, Canada K1H 8L1
    Paediatr Anaesth 17:460-3. 2007
    ..The aim of this study was to evaluate the safety and efficacy of a combination of propofol and remifentanil deep sedation in spontaneously breathing children less than 7 years of age undergoing upper and/or lower gastrointestinal endoscopy...

Research Grants80

  1. Mechanisms of anesthetic effects on tachykinin induced airway tone
    Charles Emala; Fiscal Year: 2007
    ..1 million from COPD. An increasing number of patients with these diseases require anesthesia and bronchospasm especially during induction and emergence from anesthesia carries significant morbidity...
  2. Etomidate Analogues as Safer General Anesthetics
    Douglas E Raines; Fiscal Year: 2010
    ..S. alone, nearly 30 million general anesthetics are administered each year. At the doses required to produce anesthesia, all general anesthetics produce serious side effects...
  3. Mechanisms of anesthetic effects on tachykinin induced airway tone
    Charles W Emala; Fiscal Year: 2010
    ..1 million from COPD. An increasing number of patients with these diseases require anesthesia and bronchospasm especially during induction and emergence from anesthesia carries significant morbidity...
  4. Neuromuscular blocker-induced asthma during anesthesia
    Charles Emala; Fiscal Year: 2006
    ..It was developed specifically to facilitate tracheal intubation during the induction of general anesthesia, but has been associated with life threatening bronchospasm...
  5. Outcomes After ACL Reconstruction: Femoral Nerve Block
    Brian Williams; Fiscal Year: 2005
    ..In the proposed project, the applicant aims to develop expertise in clinical trials to measure outcomes after anesthesia and pain management for common orthopedic procedures...
  6. BRAIN METABOLISM DURING ANESTHESIA, LOW PH1, AND HYPOXIA
    Lawrence Litt; Fiscal Year: 1993
    ..The anesthetic effect on "critical oxygen levels" will be examined by repeating the studies for issue #2 during anesthesia with halothane, isoflurane, and thiopental. 4...
  7. The Role of the Amygdala in Anesthetic-Induced Amnesia
    MICHAEL ALKIRE; Fiscal Year: 2006
    ..Understanding anesthesia requires understanding both phenomenon...
  8. Multimodal Functional Imaging of Auditory Perception Under General Anesthesia
    PATRICK PURDON; Fiscal Year: 2007
    A fundamental problem in neuroscience and medicine is to understand the mechanisms of general anesthesia. This proposal, "Multimodal Functional Imaging of Auditory Perception Under General Anesthesia", is submitted in response to the ..
  9. Anesthesia-induced Developmental Neuroapoptosis
    Vesna Jevtovic Todorovic; Fiscal Year: 2007
    Exposure of premature infants, neonates and very young children to general anesthesia is a frequent occurrence in modern medicine...
  10. Anesthesia-induced Developmental Neuroapoptosis
    Vesna Jevtovic Todorovic; Fiscal Year: 2009
    Exposure of premature infants, neonates and very young children to general anesthesia is a frequent occurrence in modern medicine...
  11. Anesthesia-induced Developmental Neuroapoptosis
    Vesna Jevtovic Todorovic; Fiscal Year: 2009
    Exposure of premature infants, neonates and very young children to general anesthesia is a frequent occurrence in modern medicine...
  12. The Role of the Amygdala in Anesthetic-Induced Amnesia
    MICHAEL ALKIRE; Fiscal Year: 2003
    ..Understanding anesthesia requires understanding both phenomenon...
  13. ACUTE TOLERANCE IN ANESTHETIC ACTIONS AND INTERACTIONS
    Igor Kissin; Fiscal Year: 2001
    ..may provide different outcomes (addition, synergism, or antagonism) regarding different components of anesthesia (e.g., unconsciousness or immobility to noxious stimulation)...
  14. Neonatal Anesthetic Neurotoxicity
    Piyush M Patel; Fiscal Year: 2010
    A premise of general anesthesia is that anesthetics produce a non-toxic and reversible state of unconsciousness...
  15. Arousal, orexins and anesthesia
    MAX KELZ; Fiscal Year: 2007
    ..anesthetics varies across a population with some individuals requiring a higher dose to achieve a given depth of anesthesia. Anesthetic resistance may present in humans as awareness under anesthesia...
  16. Isoflurane: Identification of Key New Targets
    Aaron P Fox; Fiscal Year: 2010
    ..Isoflurane, a halogenated volatile anesthetic, is thought to produce anesthesia by depressing central nervous system function...
  17. Isoflurane: Identification of Key New Targets
    Aaron Fox; Fiscal Year: 2009
    ..Isoflurane, a halogenated volatile anesthetic, is thought to produce anesthesia by depressing central nervous system function...
  18. Propofol Interactions with GABA-A Receptors
    MYLES AKABAS; Fiscal Year: 2007
    Each year millions of people undergo general anesthesia so that surgeons can perform life-saving operations...
  19. Propofol Interactions with GABA-A Receptors
    MYLES AKABAS; Fiscal Year: 2009
    Each year millions of people undergo general anesthesia so that surgeons can perform life-saving operations...