anesthesia

Summary

Summary: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.

Top Publications

  1. ncbi Anesthesia in a patient with multiple endocrine abnormalities. Case report
    Renato Toledo Maciel
    Hospital Universitário Clementino Fraga Filho da Faculdade de Medicina da Universidade Federal do Rio de Janeiro HUCFF UFRJ, Rio de Janeiro, RJ
    Rev Bras Anestesiol 58:172-8. 2008
  2. ncbi Current practice of preoperative fasting: a nationwide survey in Japanese anesthesia-teaching hospitals
    Nobuaki Shime
    Department of Anesthesiology, Postgraduate School of Medicine, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kamigyo ku, Kyoto, 602 8566, Japan
    J Anesth 19:187-92. 2005
  3. ncbi Low degree of anesthesia increases the risk of neurogenic pulmonary edema development
    J Sedy
    Institute of Experimental Medicine, ASCR, Prague, Czech Republic
    Med Hypotheses 70:308-13. 2008
  4. doi Percutaneous and minimally invasive valve procedures: a scientific statement from the American Heart Association Council on Cardiovascular Surgery and Anesthesia, Council on Clinical Cardiology, Functional Genomics and Translational Biology Interdisciplin
    Todd K Rosengart
    State University of New York Stony Brook, USA
    Circulation 117:1750-67. 2008
  5. doi Population imaging of ongoing neuronal activity in the visual cortex of awake rats
    David S Greenberg
    Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
    Nat Neurosci 11:749-51. 2008
  6. ncbi Society for Ambulatory Anesthesia guidelines for the management of postoperative nausea and vomiting
    Tong J Gan
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesth Analg 105:1615-28, table of contents. 2007
  7. pmc Serotonin-mushroom body circuit modulating the formation of anesthesia-resistant memory in Drosophila
    Pei Tseng Lee
    Department of Life Science, National Tsing Hua University, Hsinchu 30013, Taiwan
    Proc Natl Acad Sci U S A 108:13794-9. 2011
  8. ncbi Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia
    Emmanuel Planel
    Columbia University Medical Center, Department of Pathology, Taub Institute for Alzheimer s Disease Research, New York, New York 10032, USA
    J Neurosci 27:3090-7. 2007
  9. pmc Propofol anesthesia and sleep: a high-density EEG study
    Michael Murphy
    Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
    Sleep 34:283-91A. 2011
  10. ncbi Effect of carbon dioxide pneumoperitoneum on development of atelectasis during anesthesia, examined by spiral computed tomography
    Lena E Andersson
    Department of Anesthesiology and Intensive Care, Karolinska University Hospital, Huddinge, Sweden
    Anesthesiology 102:293-9. 2005

Detail Information

Publications325 found, 100 shown here

  1. ncbi Anesthesia in a patient with multiple endocrine abnormalities. Case report
    Renato Toledo Maciel
    Hospital Universitário Clementino Fraga Filho da Faculdade de Medicina da Universidade Federal do Rio de Janeiro HUCFF UFRJ, Rio de Janeiro, RJ
    Rev Bras Anestesiol 58:172-8. 2008
    ..The patient remained hemodynamically stable even during the pneumoperitoneum. She developed postoperative episodes of hypoglycemia, which motivated the re-operation...
  2. ncbi Current practice of preoperative fasting: a nationwide survey in Japanese anesthesia-teaching hospitals
    Nobuaki Shime
    Department of Anesthesiology, Postgraduate School of Medicine, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kamigyo ku, Kyoto, 602 8566, Japan
    J Anesth 19:187-92. 2005
    ..conducted a nationwide survey to investigate the current practice of the preoperative fasting period in Japanese anesthesia-teaching hospitals...
  3. ncbi Low degree of anesthesia increases the risk of neurogenic pulmonary edema development
    J Sedy
    Institute of Experimental Medicine, ASCR, Prague, Czech Republic
    Med Hypotheses 70:308-13. 2008
    ..We introduce a new hypothesis that high levels of anesthesia might protect the organism against the development of neurogenic pulmonary edema due to a more pronounced ..
  4. doi Percutaneous and minimally invasive valve procedures: a scientific statement from the American Heart Association Council on Cardiovascular Surgery and Anesthesia, Council on Clinical Cardiology, Functional Genomics and Translational Biology Interdisciplin
    Todd K Rosengart
    State University of New York Stony Brook, USA
    Circulation 117:1750-67. 2008
    ....
  5. doi Population imaging of ongoing neuronal activity in the visual cortex of awake rats
    David S Greenberg
    Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
    Nat Neurosci 11:749-51. 2008
    ..b>Anesthesia modulated population-wide synchronization and the relationship between firing rate and correlation...
  6. ncbi Society for Ambulatory Anesthesia guidelines for the management of postoperative nausea and vomiting
    Tong J Gan
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesth Analg 105:1615-28, table of contents. 2007
    ..and expertise in postoperative nausea and vomiting (PONV) under the auspices of The Society of Ambulatory Anesthesia. The panel critically evaluated the current medical literature on PONV to provide an evidence-based reference ..
  7. pmc Serotonin-mushroom body circuit modulating the formation of anesthesia-resistant memory in Drosophila
    Pei Tseng Lee
    Department of Life Science, National Tsing Hua University, Hsinchu 30013, Taiwan
    Proc Natl Acad Sci U S A 108:13794-9. 2011
    Pavlovian olfactory learning in Drosophila produces two genetically distinct forms of intermediate-term memories: anesthesia-sensitive memory, which requires the amnesiac gene, and anesthesia-resistant memory (ARM), which requires the ..
  8. ncbi Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia
    Emmanuel Planel
    Columbia University Medical Center, Department of Pathology, Taub Institute for Alzheimer s Disease Research, New York, New York 10032, USA
    J Neurosci 27:3090-7. 2007
    Postoperative cognitive dysfunction, confusion, and delirium are common after general anesthesia in the elderly, with symptoms persisting for months or years in some patients...
  9. pmc Propofol anesthesia and sleep: a high-density EEG study
    Michael Murphy
    Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
    Sleep 34:283-91A. 2011
    ..We used high-density electroencephalography (hd-EEG) and source modeling to investigate the cortical processes underlying propofol anesthesia and compare them to sleep.
  10. ncbi Effect of carbon dioxide pneumoperitoneum on development of atelectasis during anesthesia, examined by spiral computed tomography
    Lena E Andersson
    Department of Anesthesiology and Intensive Care, Karolinska University Hospital, Huddinge, Sweden
    Anesthesiology 102:293-9. 2005
    b>Anesthesia per se results in atelectasis development in the dependent regions of the lungs. The effect of pneumoperitoneum on atelectasis formation is not known...
  11. ncbi Anesthesia for a patient with morbid obesity using dexmedetomidine without narcotics
    Roger E Hofer
    Department of Anesthesiology, Mayo Clinic College of Medicine, 200 First Street S W, Rochester, MN 55905, USA
    Can J Anaesth 52:176-80. 2005
    ..To describe the anesthetic management of a patient with extreme obesity undergoing bariatric surgery whose intraoperative narcotic management was entirely substituted with dexmedetomidine...
  12. doi The incidence and nature of adverse events during pediatric sedation/anesthesia with propofol for procedures outside the operating room: a report from the Pediatric Sedation Research Consortium
    Joseph P Cravero
    Department of Anesthesiology and Pediatrics, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756 0001, USA
    Anesth Analg 108:795-804. 2009
    We used a large database of prospectively collected data on pediatric sedation/anesthesia outside the operating room provided by a wide range of pediatric specialists to delineate the nature and frequency of adverse events associated with ..
  13. pmc Stable and dynamic cortical electrophysiology of induction and emergence with propofol anesthesia
    Jonathan D Breshears
    Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:21170-5. 2010
    ..comprehensive recording of invasive human cortical physiology during both induction and emergence from propofol anesthesia. Propofol-induced transitions in and out of consciousness (defined here as responsiveness) were characterized by ..
  14. pmc Early childhood exposure to anesthesia and risk of developmental and behavioral disorders in a sibling birth cohort
    Charles DiMaggio
    Department of Anesthesiology, Columbia University, 622 West 168 St, New York, NY 10032, USA
    Anesth Analg 113:1143-51. 2011
    ..However, the clinical relevance of these findings to children undergoing anesthesia remains unclear...
  15. ncbi Nerve injury associated with anesthesia: a closed claims analysis
    F W Cheney
    Department of Anesthesiology, University of Washington School of Medicine, Seattle 98195, USA
    Anesthesiology 90:1062-9. 1999
    Nerve injury associated with anesthesia is a significant source of morbidity for patients and liability for anesthesiologists...
  16. doi Microcirculatory alterations in cardiac surgery: effects of cardiopulmonary bypass and anesthesia
    Daniel De Backer
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Ann Thorac Surg 88:1396-403. 2009
    ..Heterogeneity in microvascular perfusion is associated with impaired tissue oxygenation. We hypothesized that cardiac surgery with or without cardiopulmonary bypass (CPB) could induce microvascular alterations...
  17. pmc Visualization of murine intranasal dosing efficiency using luminescent Francisella tularensis: effect of instillation volume and form of anesthesia
    Mark A Miller
    The University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 7:e31359. 2012
    ..delivery via intranasal dosing performed either with differing instillation volumes or different types of anesthesia. FTLVS was rendered luminescent via transformation with a reporter plasmid that constitutively expressed the ..
  18. ncbi Signaling at A-kinase anchoring proteins organizes anesthesia-sensitive memory in Drosophila
    Martin Schwaerzel
    Saarland University, Faculty 8 3 Life Science, Department of Zoology and Physiology, 66041 Saarbrucken, Germany
    J Neurosci 27:1229-33. 2007
    ..Together, our results show that subcellular organization of signaling components plays a key role in memory processing...
  19. pmc Cyclic and sleep-like spontaneous alternations of brain state under urethane anaesthesia
    Elizabeth A Clement
    Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 3:e2004. 2008
    ....
  20. doi Update on tracheobronchial anatomy and flexible fiberoptic bronchoscopy in thoracic anesthesia
    Javier H Campos
    Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
    Curr Opin Anaesthesiol 22:4-10. 2009
    This review is focused on tracheobronchial anatomy and the use of flexible fiberoptic bronchoscopy in thoracic anesthesia.
  21. doi Anesthesia and the old brain
    Junxia Tang
    Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Anesth Analg 110:421-6. 2010
    ..In this special article, we summarize the rationale and evidence that the anesthetic per se is a contributor. The evidence at this point is considered suggestive and further research is needed, especially in humans...
  22. ncbi The entwined mysteries of anesthesia and consciousness: is there a common underlying mechanism?
    Stuart R Hameroff
    Department of Anesthesiology, The University of Arizona, Tucson, Arizona 85718, USA
    Anesthesiology 105:400-12. 2006
  23. pmc Successful small intestine colonization of adult mice by Vibrio cholerae requires ketamine anesthesia and accessory toxins
    Verena Olivier
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
    PLoS ONE 4:e7352. 2009
    ..Successful colonization was found to depend upon anesthesia with ketamine-xylazine and neutralization of stomach acid with sodium bicarbonate, but not streptomycin ..
  24. ncbi The use of an anesthesia information management system for prediction of antiemetic rescue treatment at the postanesthesia care unit
    A Junger
    Department of Anesthesiology and Intensive Care Medicine, Justus Liebig University, Rudolf Buchheim Str 7, D 35392 Giessen, Germany
    Anesth Analg 92:1203-9. 2001
    We used an anesthesia information management system (AIMS) to devise a score for predicting antiemetic rescue treatment as an indicator for postoperative nausea and vomiting (PONV) in the postanesthesia care unit (PACU)...
  25. ncbi Anaphylaxis during anesthesia in Norway: a 6-year single-center follow-up study
    Torkel Harboe
    Department of Anesthesia and Intensive Care, Haukeland University Hospital, Bergen, Norway
    Anesthesiology 102:897-903. 2005
    ..studies have recognized neuromuscular blocking agents as the most common cause of anaphylaxis during general anesthesia, but the reported frequencies vary considerably between countries...
  26. ncbi Heat- and anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouse
    Mihail G Chelu
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    FASEB J 20:329-30. 2006
    ..We conclude that the heterozygous expression of the Y522S mutation confers susceptibility to both heat- and anesthetic-induced MH responses...
  27. ncbi Less core hypothermia when anesthesia is induced with inhaled sevoflurane than with intravenous propofol
    T Ikeda
    Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Japan
    Anesth Analg 88:921-4. 1999
    Hypothermia after the induction of anesthesia results initially from core-to-peripheral redistribution of body heat. Sevoflurane and propofol both inhibit central thermoregulatory control, thus causing vasodilation...
  28. pmc Stimulus onset quenches neural variability: a widespread cortical phenomenon
    Mark M Churchland
    Department of Electrical Engineering, Stanford University School of Medicine, Stanford University, Stanford, California, USA
    Nat Neurosci 13:369-78. 2010
    ..This widespread variability decline suggests a rather general property of cortex, that its state is stabilized by an input...
  29. pmc Consensus statement: First International Workshop on Anesthetics and Alzheimer's disease
    Dmitri Baranov
    Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Anesth Analg 108:1627-30. 2009
    In order to review the current status of the potential relationship between anesthesia and Alzheimer's disease, a group of scientists recently met in Philadelphia for a full day of presentations and discussions...
  30. ncbi Evaluation of anesthesia effects on [18F]FDG uptake in mouse brain and heart using small animal PET
    Hiroshi Toyama
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Nucl Med Biol 31:251-6. 2004
    This study evaluates effects of anesthesia on (18)F-FDG (FDG) uptake in mouse brain and heart to establish the basic conditions of small animal PET imaging...
  31. ncbi Anesthesia induces neuronal cell death in the developing rat brain via the intrinsic and extrinsic apoptotic pathways
    J H Yon
    Department of Anesthesiology, University of Virginia Health System, P O Box 800710, Charlottesville, VA 22908, USA
    Neuroscience 135:815-27. 2005
    ..We found that the intrinsic pathway is activated early on during anesthesia exposure (within two hours), as measured by the down-regulation of bcl-x(L), up-regulation of cytochrome c and ..
  32. pmc Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis
    Annette Robichaud
    Merck Frosst Centre for Therapeutic Research, Pointe Claire Dorval, Quebec, Canada
    J Clin Invest 110:1045-52. 2002
    ..of type 4 cAMP-specific cyclic nucleotide phosphodiesterase 4 (PDE4) in reversing alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis in non-vomiting species...
  33. ncbi Prevention and treatment of postoperative nausea and vomiting
    A L Kovac
    Department of Anaesthesiology, University of Kansas Medical Center, Kansas City 66160 7415, USA
    Drugs 59:213-43. 2000
    ....
  34. doi Assessing cortico-hippocampal functional connectivity under anesthesia and kainic acid using generalized partial directed coherence
    Jiannis Taxidis
    School of Mathematical Sciences, University of Nottingham, Nottingham, NG7 2RD, UK
    Biol Cybern 102:327-40. 2010
    ..medial prefrontal cortex (mPFC) and hippocampus and within the hippocampus of the rat brain, under isoflurane anesthesia and kainic acid-induced enhanced neuronal activity...
  35. pmc Human Alzheimer and inflammation biomarkers after anesthesia and surgery
    Junxia X Tang
    Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Anesthesiology 115:727-32. 2011
    ..The authors studied human cerebrospinal fluid (CSF) biomarkers during surgery...
  36. pmc Neuronal synchrony during anesthesia: a thalamocortical model
    Jane H Sheeba
    Department of Physics, Lancaster University, Lancaster LA1 4YB, United Kingdom
    Biophys J 95:2722-7. 2008
    ..The theta- and delta-rhythms are shown to be involved in various sleep stages, and during anesthesia, they undergo changes with the depth of anesthesia...
  37. ncbi Biomarkers of acute kidney injury in anesthesia, intensive care and major surgery: from the bench to clinical research to clinical practice
    E Moore
    Department of Epidemiology and Preventive Medicine, Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia
    Minerva Anestesiol 76:425-40. 2010
    ..These biomarkers have many potential applications during anesthesia and in the ICU...
  38. doi Anesthesia for nonobstetric surgery: maternal and fetal considerations
    Theodore G Cheek
    Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Clin Obstet Gynecol 52:535-45. 2009
    This monograph will review and update our understanding of the administration of anesthesia for nonobstetric surgery and its maternal and fetal effects...
  39. pmc Cognitive and behavioral outcomes after early exposure to anesthesia and surgery
    Randall P Flick
    Department of Anesthesiology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Pediatrics 128:e1053-61. 2011
    ..the possible significance of these findings in children, we investigated the association between exposure to anesthesia and subsequent (1) learning disabilities (LDs), (2) receipt of an individualized education program for an ..
  40. ncbi Factors predictive of patient satisfaction with anesthesia
    Maurizia Capuzzo
    Department of Surgical, Anesthetic and Radiological Sciences, Section of Anesthesiology and Intensive Care, University Hospital of Ferrara, Ferrara, Italy
    Anesth Analg 105:435-42. 2007
    In this multicenter prospective study, we identified factors associated with satisfaction with anesthesia in patients staying in hospital at least 24 h after surgery.
  41. doi Cortical inhibition during burst suppression induced with isoflurane anesthesia
    Judy Fay Ferron
    Department of Stomatology, School of Medical Dentistry, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Neurosci 29:9850-60. 2009
    ..Thus cortical hyperexcitability during BS is favored by suppressed inhibition...
  42. ncbi Reducing the risk of anaphylaxis during anesthesia: 2011 updated guidelines for clinical practice
    P M Mertes
    Service d Anesthésie Réanimation Chirurgicale Inserm U911, CHU de Nancy, Hopital Central, Nancy, France
    J Investig Allergol Clin Immunol 21:442-53. 2011
    ..represent the updated consensus of experts in the field of immediate hypersensitivity reactions occurring during anesthesia. They provide a series of valid, widely accepted, effective, and easily teachable guidelines that are the fruit ..
  43. doi Pathomechanisms and complications related to patient positioning and anesthesia during shoulder arthroscopy
    Derek D Rains
    Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, 98195 4060, USA
    Arthroscopy 27:532-41. 2011
    ..the reports and studies documenting independent and dependent complications related to patient positioning and anesthesia during arthroscopic shoulder surgery...
  44. doi Anesthesia-related cardiac arrest in children with heart disease: data from the Pediatric Perioperative Cardiac Arrest (POCA) registry
    Chandra Ramamoorthy
    Department of Anesthesiology, S tanford University School of Medicine, Stanford, California, USA
    Anesth Analg 110:1376-82. 2010
    From 1994 to 2005, the Pediatric Perioperative Cardiac Arrest Registry collected data on 373 anesthesia-related cardiac arrests (CAs) in children, 34% of whom had congenital or acquired heart disease (HD).
  45. ncbi The incidence and risk factors for hypotension after spinal anesthesia induction: an analysis with automated data collection
    Bernd Hartmann
    Department of Anesthesiology and Intensive Care Medicine, Justus Liebig University Giessen, Rudolf Buchheim Strasse 7, D 35392 Giessen, Germany
    Anesth Analg 94:1521-9, table of contents. 2002
    We sought to identify factors that are associated with hypotension after the induction of spinal anesthesia (SpA) by using an anesthesia information management system...
  46. pmc Influence of a brief episode of anesthesia during the induction of experimental brain trauma on secondary brain damage and inflammation
    Clara Luh
    Department of Anesthesiology, Medical Center of the Johannes Gutenberg University, Mainz, Germany
    PLoS ONE 6:e19948. 2011
    It is unclear whether a single, brief, 15-minute episode of background anesthesia already modulates delayed secondary processes after experimental brain injury...
  47. doi Anesthesia in the patient with multiple drug allergies: are all allergies the same?
    Pascale Dewachter
    Pôle d Anesthésie Réanimation, Hopital Gabriel Montpied, Clermont Ferrand, France
    Curr Opin Anaesthesiol 24:320-5. 2011
    ..The aim of this review is to facilitate the recognition of risk factors for perioperative anaphylaxis and help the management of patients with 'multiple drug allergies' during the perioperative period...
  48. pmc Anesthetic modulation of neuroinflammation in Alzheimer's disease
    Junxia X Tang
    Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Anaesthesiol 24:389-94. 2011
    To summarize key studies and recent thought on the role of neuroinflammation in chronic neurodegeneration, and whether it can be modulated by anesthesia and surgery.
  49. pmc Epidemiology of anesthesia-related mortality in the United States, 1999-2005
    Guohua Li
    Center for Health Policy and Outcomes in Anesthesia and Critical Care, Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Anesthesiology 110:759-65. 2009
    Previous research on anesthesia-related mortality in the United States was limited to data from individual hospitals. The purpose of this study was to examine the epidemiologic patterns of anesthesia-related deaths at the national level.
  50. doi Influence of anesthesia on cerebral blood flow, cerebral metabolic rate, and brain functional connectivity
    Vincent Bonhomme
    University Department of Anesthesia and ICM, CHR Citadelle, Belgium
    Curr Opin Anaesthesiol 24:474-9. 2011
    To describe recent studies exploring brain function under the influence of hypnotic anesthetic agents, and their implications on the understanding of consciousness physiology and anesthesia-induced alteration of consciousness.
  51. doi Bispectral index-guided administration of anesthesia for transsphenoidal resection of pituitary tumors: a comparison of 3 anesthetic techniques
    Zulfiqar Ali
    Department of Neuroanaesthesiology, Neurosciences Center, All India Institute of Medical Sciences, New Delhi, India
    J Neurosurg Anesthesiol 21:10-5. 2009
    The main aims of anesthesia for pituitary surgery include maintenance of hemodynamic stability, provision of conditions that facilitate surgical exposure, and a smooth emergence to facilitate a prompt neurologic assessment...
  52. pmc Safety and efficacy of various combinations of injectable anesthetics in BALB/c mice
    Sandra Buitrago
    Department of Laboratory Animal Resources, Roswell Park Cancer Institute, Buffalo, NY, USA
    J Am Assoc Lab Anim Sci 47:11-7. 2008
    ..ketamine-xylazine-buprenorphine, and ketamine-xylazine-carprofen--were compared for their ability to produce anesthesia in BALB/c mice...
  53. ncbi Anesthesia for thoracic surgery in morbidly obese patients
    Jens Lohser
    Department of Anesthesiology, Stanford University School of Medicine, Stanford, California, USA
    Curr Opin Anaesthesiol 20:10-4. 2007
    ..Obese patients have altered anatomy and physiology, and usually have associated comorbid medical conditions that may complicate their operative course and increase their risks for postoperative complications...
  54. ncbi Redesigning a morbidity and mortality program in a university-affiliated pediatric anesthesia department
    Conor McDonnell
    Department of Anesthesia and Pain Medicine, The Hospital for Sick Children, Toronto
    Jt Comm J Qual Patient Saf 36:117-25. 2010
    ..The M&M activities were developed in a university-affiliated pediatric anesthesia department as part of a departmental quality improvement (QI) initiative...
  55. pmc A protocol for use of medetomidine anesthesia in rats for extended studies using task-induced BOLD contrast and resting-state functional connectivity
    Christopher P Pawela
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Neuroimage 46:1137-47. 2009
    ..In the secondary infusion period using 300 microg/kg/h, resting-state functional connectivity is enhanced...
  56. doi Oxygen in neonatal anesthesia: friend or foe?
    Augusto Sola
    Mid Atlantic Neonatology Associates and Atlantic Neonatal Research Institute, Morristown, NJ 07960, USA
    Curr Opin Anaesthesiol 21:332-9. 2008
    ..Hypoxemia is due to many pathophysiological causes; avoiding hypoxemia is an important objective during neonatal anesthesia. Nevertheless, the only known cause for hyperoxemia is the excess and unnecessary administration of oxygen by ..
  57. ncbi Use of in-office anesthesia during non-surgical radiofrequency collagen denaturation for stress urinary incontinence
    W Glen Wells
    Alabama Research Center, Birmingham, AL 35209, USA
    Curr Med Res Opin 23:1279-84. 2007
    ..This multicenter trial aimed to demonstrate the feasibility, safety, and efficacy of an oral sedation and local anesthetic regimen in performing RF collagen denaturation...
  58. doi Impact of anesthesia on transcranial electric motor evoked potential monitoring during spine surgery: a review of the literature
    Anthony C Wang
    Department of Neurosurgery, University of Michigan Health System, Ann Arbor, Michigan 48109 5338, USA
    Neurosurg Focus 27:E7. 2009
    ..b>Anesthesia, however, can significantly affect the reliability of TcMEP monitoring...
  59. pmc The effects of carbon dioxide anesthesia and anoxia on rapid cold-hardening and chill coma recovery in Drosophila melanogaster
    Theresa L Nilson
    Department of Biological Sciences University of Nevada, Las Vegas, NV 89154 4004, USA
    J Insect Physiol 52:1027-33. 2006
    ..Exposure to CO(2) anesthesia increases chill coma recovery time, but this effect disappears if the flies are given 90 min recovery in air ..
  60. ncbi The effects of sevoflurane and desflurane anesthesia on QTc interval and cardiac rhythm in children
    Ebru Aypar
    Section of Pediatric Cardiology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Paediatr Anaesth 17:563-7. 2007
    ..We assessed the effects of desflurane anesthesia on QTc interval and cardiac rhythm and compared them with sevoflurane anesthesia in children.
  61. doi Temporal scaling properties and spatial synchronization of spontaneous blood oxygenation level-dependent (BOLD) signal fluctuations in rat sensorimotor network at different levels of isoflurane anesthesia
    Kun Wang
    LIAMA Center for Computational Medicine, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China
    NMR Biomed 24:61-7. 2011
    ..In order to obtain more insights into this relationship and, in particular, the effects of anesthesia thereupon, we investigated the spatial and temporal correlations of spontaneous BOLD fluctuations in ..
  62. doi Bruchpilot, a synaptic active zone protein for anesthesia-resistant memory
    Stephan Knapek
    Max Planck Institut fur Neurobiologie, 82152 Martinsried, Germany
    J Neurosci 31:3453-8. 2011
    ..We further demonstrate that Brp in the Kenyon cells preferentially functions for anesthesia-resistant memory...
  63. ncbi Anesthesia for patients with congenital long QT syndrome
    Susan J Kies
    Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Anesthesiology 102:204-10. 2005
    ..Certain drugs, including anesthetic agents, are known to contribute to QT prolongation. After reviewing the literature the authors give recommendations for the anesthetic management of these patients in the perioperative period...
  64. doi Anesthesia and its allied disciplines in the developing world: a nationwide survey of the Republic of Zambia
    Stefan Jochberger
    Department of Anesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria
    Anesth Analg 106:942-8, table of contents. 2008
    ..To improve survival of acutely and critically ill patients in these countries, basic problems and demands of anesthesia care need to be identified...
  65. ncbi The role of nicotinic acetylcholine receptors in the mechanisms of anesthesia
    Edomer Tassonyi
    Division of Anesthesiology, Department of Anesthesiology, Pharmacology and Surgical Intensive Care APSIC, Geneva University Hospitals, Geneva, Switzerland
    Brain Res Bull 57:133-50. 2002
    ..Although nicotinic acetylcholine receptors are not directly involved in the hypnotic component of anesthesia, it is possible that modulation of central nicotinic transmission by volatile agents contributes to analgesia...
  66. ncbi Anesthesia-induced developmental neuroapoptosis. Does it happen in humans?
    John W Olney
    Anesthesiology 101:273-5. 2004
  67. ncbi Anesthesia can cause sustained hyperglycemia in C57/BL6J mice
    E T Brown
    Center for Vision Research, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Vis Neurosci 22:615-8. 2005
    Effects of anesthesia on the blood glucose of C57/BL6J mice were evaluated under conditions commonly used for testing retinal sensitivity with electroretinographic (ERG) recordings...
  68. doi Clinical anesthesia causes permanent damage to the fetal guinea pig brain
    Sabina Rizzi
    Department of Anesthesiology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Brain Pathol 18:198-210. 2008
    Exposure of the immature brain to general anesthesia is common. The safety of this practice has recently been challenged in view of evidence that general anesthetics can damage developing mammalian neurons...
  69. ncbi New developments in pediatric cardiac anesthesia
    Laura K Diaz
    The Arthur S Keats Division of Pediatric Cardiovascular Anesthesiology, Texas Children s Hospital, Houston, TX 77030, USA
    Anesthesiol Clin North America 23:655-76, viii. 2005
    As the practice of pediatric cardiac anesthesia continues to grow, anesthesiologists now routinely care for patients ranging in size from less than 2 kg to more than 100 kg...
  70. ncbi Weak intermolecular associations and anesthesia
    Camille Sandorfy
    Departement de Chimie, Universite de Montreal, Montreal, Quebec
    Anesthesiology 101:1225-7. 2004
  71. ncbi How depth of anesthesia influences the blood oxygenation level-dependent signal from the visual cortex of children
    V L Marcar
    Department of Neuropsychology, University of Zurich, Zurich, Switzerland
    AJNR Am J Neuroradiol 27:799-805. 2006
    ..MR imaging in young children or infants frequently involves measuring a clinical population under sedation or anesthesia. We examined the effect of depth of anesthesia on the extent and amplitude of the blood oxygen level-dependent (..
  72. pmc A retrospective cohort study of the association of anesthesia and hernia repair surgery with behavioral and developmental disorders in young children
    Charles DiMaggio
    Department of Epidemiology, Mailman School of Public Health, New York, NY, USA
    J Neurosurg Anesthesiol 21:286-91. 2009
    ..of the potential association of surgery and its concurrent exposure to anesthetic agents with neurotoxicity and underscore the need for more rigorous clinical research on the long-term effects of surgery and anesthesia in children.
  73. ncbi Angiotensin-converting enzyme inhibitors: mechanisms of action and implications in anesthesia practice
    Rahim Behnia
    Department of Anesthesiology and Pain Management, John H Stroger Jr Hospital of Cook County, Chicago, IL 60612, USA
    Curr Pharm Des 9:763-76. 2003
    ..their possible interaction with anesthetic agents must be an integral part of clinical decision-making during anesthesia Hemodynamic variation during anesthesia is mainly related to specific effects of anesthetic agents on ..
  74. ncbi Contralateral hand anesthesia transiently improves poststroke sensory deficits
    Bernhard Voller
    Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Ann Neurol 59:385-8. 2006
    ..To test a possible strategy to alleviate somatosensory deficits after stroke...
  75. ncbi Anesthetic management and one-year mortality after noncardiac surgery
    Terri G Monk
    Department of Anesthesiology Duke University Medical Center, Durham, NC 27705, USA
    Anesth Analg 100:4-10. 2005
    ..We designed a prospective observational study of adult patients undergoing major noncardiac surgery with general anesthesia to determine if mortality in the first year after surgery is associated with demographic, preoperative clinical, ..
  76. ncbi Development of a measure of patient satisfaction with monitored anesthesia care: the Iowa Satisfaction with Anesthesia Scale
    F Dexter
    Department of Anesthesia, University of Iowa, Iowa City 52242, USA
    Anesthesiology 87:865-73. 1997
    The authors describe development of the Iowa Satisfaction with Anesthesia Scale (ISAS) for monitored anesthesia care (MAC). Patients complete the self-administered written questionnaire before discharge from the hospital...
  77. ncbi The effects of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam on arterial blood pH, blood gases, mean arterial blood pressure and heart rate in adult male rats
    S K Wixson
    Department of Comparative Medicine, Milton S Hershey Medical Center, Pennsylvania State University, Hershey 17033
    Lab Anim Sci 37:736-42. 1987
    ..Throughout all dosages investigated, the ketamine-diazepam combination showed the least overall effects on ventilation and perfusion of the four parenteral drug combinations studied...
  78. ncbi Distress during the induction of anesthesia and postoperative behavioral outcomes
    Z N Kain
    Department of Anesthesiology, Yale School of Medicine, New Haven, Connecticut, USA
    Anesth Analg 88:1042-7. 1999
    We determined whether children who are extremely anxious during the induction of anesthesia are more at risk of developing postoperative negative behavioral changes compared with children who appear calm during the induction process...
  79. ncbi Trends in anesthesia-related death and brain damage: A closed claims analysis
    Frederick W Cheney
    Department of Anesthesiology, University of Washington, School of Medicine, Seattle, WA 98195 6540, USA
    Anesthesiology 105:1081-6. 2006
    ....
  80. ncbi Cellular and network mechanisms of slow oscillatory activity (<1 Hz) and wave propagations in a cortical network model
    Albert Compte
    Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurophysiol 89:2707-25. 2003
    Slow oscillatory activity (<1 Hz) is observed in vivo in the cortex during slow-wave sleep or under anesthesia and in vitro when the bath solution is chosen to more closely mimic cerebrospinal fluid...
  81. ncbi Educating patients about anesthesia: a systematic review of randomized controlled trials of media-based interventions
    Anna Lee
    Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, China
    Anesth Analg 96:1424-31, table of contents. 2003
    In this systematic review, we compared the effectiveness of media-based patient education about anesthesia. Fifteen randomized controlled trials (n = 1506) were identified after a systematic search of electronic databases (MEDLINE, EMBASE,..
  82. ncbi Integration and segregation of activity in entorhinal-hippocampal subregions by neocortical slow oscillations
    Yoshikazu Isomura
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, New Jersey 07102, USA
    Neuron 52:871-82. 2006
    ..Thus, neo/paleocortical and hippocampal networks periodically reset, self-organize, and temporally coordinate their cell assemblies via the slow oscillation...
  83. ncbi Muscle relaxation does not alter hypnotic level during propofol anesthesia
    Robert Greif
    Department of Anesthesiology and Intensive Care Medicine, Donauspital SMZO, Vienna, Austria
    Anesth Analg 94:604-8; table of contents. 2002
    ..BIS averaged 95 plus/minus 4 before induction of anesthesia, and decreased significantly to 40 plus/minus 5 after propofol administration...
  84. ncbi Anesthesia for electroconvulsive therapy
    Zhengnian Ding
    Department of Anesthesiology and Pain Management, First Affiliated Hospital of Nanjing Medical University, China
    Anesth Analg 94:1351-64. 2002
  85. ncbi Reactive oxygen species as mediators of cardiac injury and protection: the relevance to anesthesia practice
    Leo G Kevin
    Anesthesiology Research Laboratories, 8701 Watertown Plank Road, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Anesth Analg 101:1275-87. 2005
    ..The sources of ROS, the means by which they induce cardiac injury or activate protective signaling pathways, the results of clinical studies evaluating ROS scavengers, and the effects of anesthetic drugs on ROS are each discussed...
  86. ncbi Non-invasive intraoperative monitoring of blood pressure and arterial pCO2 during surgical anesthesia in mice
    Serge C Thal
    Institute for Surgical Research, University of Munich Medical Center, Grosshadern, Munich, Germany
    J Neurosci Methods 159:261-7. 2007
    ..Thereby the current study may help to reduce animal numbers and perform mice experiments under more defined and controlled physiological conditions in the future...
  87. ncbi Anesthesia and other considerations for in vivo imaging of small animals
    Isabel J Hildebrandt
    Department of Molecular and Medical Pharmacology at the David Geffen School of Medicine at the University of California, Los Angeles, CA 90095 6942, USA
    ILAR J 49:17-26. 2008
    ..In contrast to human studies, however, imaging of small animals generally requires anesthesia, and anesthetic agents can have unintended effects on animal physiology that may confound the results of the ..
  88. ncbi Rocuronium versus succinylcholine for rapid sequence induction of anesthesia and endotracheal intubation: a prospective, randomized trial in emergent cases
    Mathias Sluga
    Department of Anesthesia, Krankenhaus Thusis, Switzerland
    Anesth Analg 101:1356-61. 2005
    When anesthesia is induced with propofol in elective cases, endotracheal intubation conditions are not different between succinylcholine and rocuronium approximately 60 s after the injection of the neuromuscular relaxant...
  89. ncbi Brain-state- and cell-type-specific firing of hippocampal interneurons in vivo
    Thomas Klausberger
    MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, Oxford University, Mansfield Road, Oxford OX1 3TH, UK
    Nature 421:844-8. 2003
    ..We conclude that the diversity of interneurons, innervating distinct domains of pyramidal cells, emerged to coordinate the activity of pyramidal cells in a temporally distinct and brain-state-dependent manner...
  90. doi Anesthesia and cognitive performance in children: no evidence for a causal relationship
    Meike Bartels
    Department of Biological Psychology, VU University, Amsterdam, The Netherlands
    Twin Res Hum Genet 12:246-53. 2009
    Recent findings of an association between anesthesia administration in the first three years of life and later learning disabilities have created concerns that anesthesia has neurotoxic effects on synaptogenesis, causing later learning ..
  91. doi Systematic review of questionnaires measuring patient satisfaction in ambulatory anesthesia
    Pratamaporn Chanthong
    Department of Anesthesia, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Canada
    Anesthesiology 110:1061-7. 2009
    Patient satisfaction has become an important component of quality improvement in ambulatory anesthesia services. However, it is difficult to measure due to its subjective and complex psychological construct...
  92. ncbi Auditory cortical neuron response differences under isoflurane versus pentobarbital anesthesia
    S W Cheung
    W M Keck Center for Integrative Neuroscience, Department of Otolaryngology, University of California, San Francisco 94143 0342, USA
    Hear Res 156:115-27. 2001
    ..of feline primary auditory cortex neurons to simple sounds were compared for isoflurane versus pentobarbital anesthesia in a within subject study control design...
  93. ncbi Positioning the morbidly obese patient for anesthesia
    Jay B Brodsky
    Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Obes Surg 12:751-8. 2002
    ..An understanding of the physiologic changes that can occur is essential for the successful management of these patients...
  94. doi Electroencephalographic order pattern analysis for the separation of consciousness and unconsciousness: an analysis of approximate entropy, permutation entropy, recurrence rate, and phase coupling of order recurrence plots
    Denis Jordan
    Department of Anesthesiology, Klinikum rechts der Isar, Technische Universitat Munchen, Germany
    Anesthesiology 109:1014-22. 2008
    ..g., approximate entropy, have been suggested as measures of the hypnotic component of anesthesia. Compared with linear methods, they may detect additional information and quantify the irregularity of a ..
  95. ncbi Anesthesia condition for (18)F-FDG imaging of lung metastasis tumors using small animal PET
    Sang Keun Woo
    Division of Nuclear Medicine and RI Application, Korea Institute of Radiological and Medical Sciences KIRAMS, Nowon Gu, Seoul 139 706, South Korea
    Nucl Med Biol 35:143-50. 2008
    ..The aim of this study was to establish the anesthesia condition for imaging of lung metastasis tumor using small animal (18)F-FDG PET.
  96. ncbi Induction of anesthesia and insertion of a laryngeal mask airway in the prone position for minor surgery
    Alexander Ng
    University Department of Anaesthesia, Critical Care and Pain Management, University Hospitals of Leicester, NHS Trust, Leicester Royal Infirmary, Leicester, England
    Anesth Analg 94:1194-8, table of contents. 2002
    ..of the prone position for surgery presents potential obstacles to rapid tracking of patients during ambulatory anesthesia. We describe a prospective audit of 73 patients who placed themselves in the prone position; anesthesia was ..
  97. doi Anesthesia and neurodevelopment in children: time for an answer?
    Lena S Sun
    Department of Anesthesiology and Pediatrics, Columbia University, New York, NY, USA
    Anesthesiology 109:757-61. 2008
  98. ncbi Plasma concentrations of neuroactive steroids before and after electroconvulsive therapy in major depression
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany
    Neuropsychopharmacology 30:1181-6. 2005
    ....
  99. ncbi Fatal and non fatal cardiac arrests related to anesthesia
    P Biboulet
    Department of Anesthesiology and Critical Care A, Lapeyronie University Hospital, Montpellier, France
    Can J Anaesth 48:326-32. 2001
    The aim of this study was to assess the incidence and causes of cardiac arrests related to anesthesia.
  100. ncbi Anesthesia-related cardiac arrest in children: update from the Pediatric Perioperative Cardiac Arrest Registry
    Sanjay M Bhananker
    Department of Anesthesiology, University of Washington School of Medicine, Seattle, WA, USA
    Anesth Analg 105:344-50. 2007
    ..Changes in pediatric anesthesia practice may have altered the causes of cardiac arrest in anesthetized children.
  101. ncbi Injury and liability associated with monitored anesthesia care: a closed claims analysis
    Sanjay M Bhananker
    Department of Anesthesiology, University of Washington, Virginia Mason Medical Center, Seattle, WA 98195, USA
    Anesthesiology 104:228-34. 2006
    To assess the patterns of injury and liability associated with monitored anesthesia care (MAC) compared with general and regional anesthesia, the authors reviewed closed malpractice claims in the American Society of Anesthesiologists ..

Research Grants84

  1. Mechanisms of anesthetic effects on tachykinin induced airway tone
    Charles Emala; Fiscal Year: 2007
    ..1 million from COPD. An increasing number of patients with these diseases require anesthesia and bronchospasm especially during induction and emergence from anesthesia carries significant morbidity...
  2. Etomidate Analogues as Safer General Anesthetics
    Douglas E Raines; Fiscal Year: 2010
    ..S. alone, nearly 30 million general anesthetics are administered each year. At the doses required to produce anesthesia, all general anesthetics produce serious side effects...
  3. Mechanisms of anesthetic effects on tachykinin induced airway tone
    Charles W Emala; Fiscal Year: 2010
    ..1 million from COPD. An increasing number of patients with these diseases require anesthesia and bronchospasm especially during induction and emergence from anesthesia carries significant morbidity...
  4. Neuromuscular blocker-induced asthma during anesthesia
    Charles Emala; Fiscal Year: 2006
    ..It was developed specifically to facilitate tracheal intubation during the induction of general anesthesia, but has been associated with life threatening bronchospasm...
  5. Outcomes After ACL Reconstruction: Femoral Nerve Block
    Brian Williams; Fiscal Year: 2005
    ..In the proposed project, the applicant aims to develop expertise in clinical trials to measure outcomes after anesthesia and pain management for common orthopedic procedures...
  6. BRAIN METABOLISM DURING ANESTHESIA, LOW PH1, AND HYPOXIA
    Lawrence Litt; Fiscal Year: 1993
    ..The anesthetic effect on "critical oxygen levels" will be examined by repeating the studies for issue #2 during anesthesia with halothane, isoflurane, and thiopental. 4...
  7. The Role of the Amygdala in Anesthetic-Induced Amnesia
    MICHAEL ALKIRE; Fiscal Year: 2006
    ..Understanding anesthesia requires understanding both phenomenon...
  8. Multimodal Functional Imaging of Auditory Perception Under General Anesthesia
    PATRICK PURDON; Fiscal Year: 2007
    A fundamental problem in neuroscience and medicine is to understand the mechanisms of general anesthesia. This proposal, "Multimodal Functional Imaging of Auditory Perception Under General Anesthesia", is submitted in response to the ..
  9. Anesthesia-induced Developmental Neuroapoptosis
    Vesna Jevtovic Todorovic; Fiscal Year: 2009
    Exposure of premature infants, neonates and very young children to general anesthesia is a frequent occurrence in modern medicine...
  10. Anesthesia-induced Developmental Neuroapoptosis
    Vesna Jevtovic Todorovic; Fiscal Year: 2007
    Exposure of premature infants, neonates and very young children to general anesthesia is a frequent occurrence in modern medicine...
  11. Anesthesia-induced Developmental Neuroapoptosis
    Vesna Jevtovic Todorovic; Fiscal Year: 2009
    Exposure of premature infants, neonates and very young children to general anesthesia is a frequent occurrence in modern medicine...
  12. The Role of the Amygdala in Anesthetic-Induced Amnesia
    MICHAEL ALKIRE; Fiscal Year: 2003
    ..Understanding anesthesia requires understanding both phenomenon...
  13. ACUTE TOLERANCE IN ANESTHETIC ACTIONS AND INTERACTIONS
    Igor Kissin; Fiscal Year: 2001
    ..may provide different outcomes (addition, synergism, or antagonism) regarding different components of anesthesia (e.g., unconsciousness or immobility to noxious stimulation)...
  14. Neonatal Anesthetic Neurotoxicity
    Piyush M Patel; Fiscal Year: 2010
    A premise of general anesthesia is that anesthetics produce a non-toxic and reversible state of unconsciousness...
  15. Arousal, orexins and anesthesia
    MAX KELZ; Fiscal Year: 2007
    ..anesthetics varies across a population with some individuals requiring a higher dose to achieve a given depth of anesthesia. Anesthetic resistance may present in humans as awareness under anesthesia...
  16. Isoflurane: Identification of Key New Targets
    Aaron Fox; Fiscal Year: 2009
    ..Isoflurane, a halogenated volatile anesthetic, is thought to produce anesthesia by depressing central nervous system function...
  17. Isoflurane: Identification of Key New Targets
    Aaron P Fox; Fiscal Year: 2010
    ..Isoflurane, a halogenated volatile anesthetic, is thought to produce anesthesia by depressing central nervous system function...
  18. Propofol Interactions with GABA-A Receptors
    MYLES AKABAS; Fiscal Year: 2009
    Each year millions of people undergo general anesthesia so that surgeons can perform life-saving operations...
  19. Propofol Interactions with GABA-A Receptors
    MYLES AKABAS; Fiscal Year: 2007
    Each year millions of people undergo general anesthesia so that surgeons can perform life-saving operations...