functional neuroimaging


Summary: Methods for visualizing REGIONAL BLOOD FLOW, metabolic, electrical, or other physiological activities in the CENTRAL NERVOUS SYSTEM using various imaging modalities.

Top Publications

  1. Hermes D, Nguyen M, Winawer J. Neuronal synchrony and the relation between the blood-oxygen-level dependent response and the local field potential. PLoS Biol. 2017;15:e2001461 pubmed publisher
  2. Chennu S, Annen J, Wannez S, Thibaut A, Chatelle C, Cassol H, et al. Brain networks predict metabolism, diagnosis and prognosis at the bedside in disorders of consciousness. Brain. 2017;140:2120-2132 pubmed publisher
    Recent advances in functional neuroimaging have demonstrated novel potential for informing diagnosis and prognosis in the unresponsive wakeful syndrome and minimally conscious states...
  3. Le Couteur D, Doust J, Creasey H, Brayne C. Political drive to screen for pre-dementia: not evidence based and ignores the harms of diagnosis. BMJ. 2013;347:f5125 pubmed publisher
  4. Bullmore E, Vertes P. From Lichtheim to rich club: brain networks and psychiatry. JAMA Psychiatry. 2013;70:780-2 pubmed publisher
  5. Hope T, Leff A, Prejawa S, Bruce R, Haigh Z, Lim L, et al. Right hemisphere structural adaptation and changing language skills years after left hemisphere stroke. Brain. 2017;140:1718-1728 pubmed publisher
  6. Baciu M, Perrone Bertolotti M. What do patients with epilepsy tell us about language dynamics? A review of fMRI studies. Rev Neurosci. 2015;26:323-41 pubmed publisher
    ..Importantly, functional neuroimaging approaches demonstrate a good degree of concordance on a theoretical level, but also a considerable ..
  7. Davey C, Breakspear M, Pujol J, Harrison B. A Brain Model of Disturbed Self-Appraisal in Depression. Am J Psychiatry. 2017;174:895-903 pubmed publisher
    ..32; 95% CI=-0.51, -0.08). The exaggerated influence of the medial prefrontal cortex on the posterior cingulate cortex in depression is a neural correlate of the disturbed self-appraisal that is characteristic of the illness. ..
  8. Attwells S, Setiawan E, Wilson A, Rusjan P, Mizrahi R, Miler L, et al. Inflammation in the Neurocircuitry of Obsessive-Compulsive Disorder. JAMA Psychiatry. 2017;74:833-840 pubmed publisher
    ..Translocator protein density increases when microglia are activated during neuroinflammation and the TSPO distribution volume (VT) is an index of TSPO density...
  9. Sheng C, Xia M, Yu H, Huang Y, Lu Y, Liu F, et al. Abnormal global functional network connectivity and its relationship to medial temporal atrophy in patients with amnestic mild cognitive impairment. PLoS ONE. 2017;12:e0179823 pubmed publisher
    ..Increased intrinsic functional connectivity in the MTL may have the potential to discriminate subjects with tendency to develop AD. ..

More Information


  1. Ciumas C, Laurent A, Saignavongs M, Ilski F, de Bellescize J, Panagiotakaki E, et al. Behavioral and fMRI responses to fearful faces are altered in benign childhood epilepsy with centrotemporal spikes (BCECTS). Epilepsia. 2017;58:1716-1727 pubmed publisher
    ..The age dependency of some of these findings supports the view that a delayed maturation of spiking cortical regions might underlie the cognitive dysfunction observed in BCECTS. ..
  2. Shaw P, Stringaris A, Nigg J, Leibenluft E. Emotion dysregulation in attention deficit hyperactivity disorder. Am J Psychiatry. 2014;171:276-93 pubmed publisher
    ..The differing predictions from each model can guide research on the much-neglected population of patients with ADHD and emotion dysregulation. ..
  3. Lee J, Kim Y, Jeong Y, Na D, Kim J, Lee K, et al. Inference of brain pathway activities for Alzheimer's disease classification. BMC Med Inform Decis Mak. 2015;15 Suppl 1:S1 pubmed publisher
    ..Moreover, discriminatory pathways between patients and cognitively normal subjects may facilitate the interpretation of functional alterations during disease progression. ..
  4. Yoshimura Y, Okamoto Y, Onoda K, Okada G, Toki S, Yoshino A, et al. Psychosocial functioning is correlated with activation in the anterior cingulate cortex and left lateral prefrontal cortex during a verbal fluency task in euthymic bipolar disorder: a preliminary fMRI study. Psychiatry Clin Neurosci. 2014;68:188-96 pubmed
    ..Both the ACC and lateral PFC regions are components of a neural network that plays a critical role in psychosocial functioning, and are often found to be affected in bipolar patients. ..
  5. Evans S, Dowell N, Tabet N, King S, Hutton S, Rusted J. Disrupted neural activity patterns to novelty and effort in young adult APOE-e4 carriers performing a subsequent memory task. Brain Behav. 2017;7:e00612 pubmed publisher
    ..This provides further evidence of abnormal hippocampal recruitment in young adult e4 carriers, manifesting as both up and downregulation of neural activity, in the absence of behavioral performance differences. ..
  6. Kikuchi Y, Attaheri A, Wilson B, Rhone A, Nourski K, Gander P, et al. Sequence learning modulates neural responses and oscillatory coupling in human and monkey auditory cortex. PLoS Biol. 2017;15:e2000219 pubmed publisher
    ..This study identifies the conserved auditory cortical neural signatures involved in monitoring learned sequencing operations, evident as modulations of transient coupling and neuronal responses to temporally structured sensory input. ..
  7. Yeo D, Wilkey E, Price G. The search for the number form area: A functional neuroimaging meta-analysis. Neurosci Biobehav Rev. 2017;78:145-160 pubmed publisher
    ..Importantly, only five studies had foci within the identified ITG NFA cluster boundary, indicating that more empirical evidence is necessary to determine the true functional specialization and regional specificity of the putative NFA. ..
  8. Denisova K, Zhao G, Wang Z, Goh S, Huo Y, Peterson B. Cortical interactions during the resolution of information processing demands in autism spectrum disorders. Brain Behav. 2017;7:e00596 pubmed publisher
    ..Increasing evidence suggests that the balance between levels of signal and noise during information processing may be disrupted in individuals with Autism Spectrum Disorders (ASD)...
  9. Ming Q, Zhong X, Zhang X, Pu W, Dong D, Jiang Y, et al. State-Independent and Dependent Neural Responses to Psychosocial Stress in Current and Remitted Depression. Am J Psychiatry. 2017;174:971-979 pubmed publisher
    ..Hyperactivation in the dorsolateral prefrontal cortex and striatum may represent a state-dependent compensatory mechanism during depression remission. ..
  10. Koenigsberg H, Denny B, Fan J, Liu X, Guerreri S, Mayson S, et al. The neural correlates of anomalous habituation to negative emotional pictures in borderline and avoidant personality disorder patients. Am J Psychiatry. 2014;171:82-90 pubmed publisher
    ..A failure to effectively engage emotional habituation processes may contribute to affective instability in borderline patients. ..
  11. Marshall G, Donovan N, Lorius N, Gidicsin C, Maye J, Pepin L, et al. Apathy is associated with increased amyloid burden in mild cognitive impairment. J Neuropsychiatry Clin Neurosci. 2013;25:302-7 pubmed publisher
    ..These results suggest that increased apathy is associated with greater amyloid burden but not regional hypometabolism in MCI. ..
  12. Huppert T, Karim H, Lin C, Alqahtani B, Greenspan S, Sparto P. Functional imaging of cognition in an old-old population: A case for portable functional near-infrared spectroscopy. PLoS ONE. 2017;12:e0184918 pubmed publisher
    ..These results demonstrate the capability for obtaining functional neuroimaging measures in residential settings, which ultimately may aid in prognosis and care related to dementia in ..
  13. Lin C, Hsieh J, Yeh T, Niddam D. Predictability-mediated pain modulation in context of multiple cues: An event-related fMRI study. Neuropsychologia. 2014;64:85-91 pubmed publisher
    ..The changing pain ratings and PAG activity across sessions reflect a dynamic learning process that may mirror decreased perceived threat of and/or decreased attention to pain in the certain condition. ..
  14. Arcaro M, Schade P, Vincent J, Ponce C, Livingstone M. Seeing faces is necessary for face-domain formation. Nat Neurosci. 2017;20:1404-1412 pubmed publisher
    ..Thus, we propose that environmental importance influences viewing behavior, viewing behavior drives neuronal activity, and neuronal activity sculpts domain formation. ..
  15. Baker J, Rojas Valverde D, Gutiérrez R, Winkler M, Fuhrimann S, Eskenazi B, et al. Portable Functional Neuroimaging as an Environmental Epidemiology Tool: A How-To Guide for the Use of fNIRS in Field Studies. Environ Health Perspect. 2017;125:094502 pubmed publisher
    The widespread application of functional neuroimaging within the field of environmental epidemiology has the potential to greatly enhance our understanding of how environmental toxicants affect brain function...
  16. Northoff G, Heiss W. Why is the distinction between neural predispositions, prerequisites, and correlates of the level of consciousness clinically relevant?: Functional brain imaging in coma and vegetative state. Stroke. 2015;46:1147-51 pubmed publisher
  17. Becker A, Ehret A, Kirsch P. From the neurobiological basis of comorbid alcohol dependence and depression to psychological treatment strategies: study protocol of a randomized controlled trial. BMC Psychiatry. 2017;17:153 pubmed publisher
    ..German Clinical Trial Register DRKS00010249 . The trial was registered January 23th 2017. ..
  18. Pan P, Sato J, Salum G, Rohde L, Gadelha A, Zugman A, et al. Ventral Striatum Functional Connectivity as a Predictor of Adolescent Depressive Disorder in a Longitudinal Community-Based Sample. Am J Psychiatry. 2017;174:1112-1119 pubmed publisher
    ..Aberrant ventral striatum functional connectivity specifically predicts future risk for depressive disorder. This finding further emphasizes the need to understand how brain reward networks contribute to youth depression. ..
  19. Ren W, Lui S, Deng W, Li F, Li M, Huang X, et al. Anatomical and functional brain abnormalities in drug-naive first-episode schizophrenia. Am J Psychiatry. 2013;170:1308-16 pubmed publisher
    ..The different structural deficits of regional gray matter observed in patients with prominent negative symptoms may provide unique insight into the early regional neuropathology of this symptom dimension in schizophrenia. ..
  20. McCrory E, Gerin M, Viding E. Annual Research Review: Childhood maltreatment, latent vulnerability and the shift to preventative psychiatry - the contribution of functional brain imaging. J Child Psychol Psychiatry. 2017;58:338-357 pubmed publisher
    ..We review extant functional neuroimaging studies of children and adolescents exposed to early neglect and/or maltreatment, including physical, ..
  21. Howes O, Bose S, Turkheimer F, Valli I, Egerton A, Stahl D, et al. Progressive increase in striatal dopamine synthesis capacity as patients develop psychosis: a PET study. Mol Psychiatry. 2011;16:885-6 pubmed publisher
  22. Suk H, van Welie I, Kodandaramaiah S, Allen B, Forest C, Boyden E. Closed-Loop Real-Time Imaging Enables Fully Automated Cell-Targeted Patch-Clamp Neural Recording In Vivo. Neuron. 2017;95:1037-1047.e11 pubmed publisher
    ..Our "imagepatching" robot is easy to implement and will help enable scalable characterization of identified cell types in intact neural circuits. ..
  23. Yun S, Shah N. Whole-brain high in-plane resolution fMRI using accelerated EPIK for enhanced characterisation of functional areas at 3T. PLoS ONE. 2017;12:e0184759 pubmed publisher
    ..Lastly, the use of EPIK for fMRI was validated with the simulation of different types of data reconstruction methods. ..
  24. Serino A, Akselrod M, Salomon R, Martuzzi R, Blefari M, Canzoneri E, et al. Upper limb cortical maps in amputees with targeted muscle and sensory reinnervation. Brain. 2017;140:2993-3011 pubmed publisher
    ..g. the integration of somatosensory feedback into current prostheses) to enable prostheses that move and feel as real limbs...
  25. Tost H, Meyer Lindenberg A. Puzzling over schizophrenia: schizophrenia, social environment and the brain. Nat Med. 2012;18:211-3 pubmed publisher
  26. Ansara Y. Improving research methodology in adolescent sexual health research. J Adolesc Health. 2015;56:367-9 pubmed publisher
  27. Ashar Y, Andrews Hanna J, Dimidjian S, Wager T. Empathic Care and Distress: Predictive Brain Markers and Dissociable Brain Systems. Neuron. 2017;94:1263-1273.e4 pubmed publisher
    ..In tests of marker specificity with an independent behavioral sample (n = 200), the empathic care marker was associated with a mixed-valence feeling state, whereas the empathic distress marker was specific to negative emotion. ..
  28. Shrestha S, Nelson E, Liow J, Gladding R, Lyoo C, Noble P, et al. Fluoxetine administered to juvenile monkeys: effects on the serotonin transporter and behavior. Am J Psychiatry. 2014;171:323-31 pubmed publisher
    ..Its purpose was to investigate effects of SSRIs on brain development in nonhuman primates using an experimental approach that randomly assigned long-term SSRI treatment or placebo. ..
  29. Hosking J, Kastman E, Dorfman H, SAMANEZ LARKIN G, Baskin Sommers A, Kiehl K, et al. Disrupted Prefrontal Regulation of Striatal Subjective Value Signals in Psychopathy. Neuron. 2017;95:221-231.e4 pubmed publisher
    ..These data suggest that cortico-striatal circuit dysregulation drives maladaptive decision making in psychopathy, supporting the notion that reward system dysfunction comprises an important neurobiological risk factor. ..
  30. Voss M, Chambon V, Wenke D, Kühn S, Haggard P. In and out of control: brain mechanisms linking fluency of action selection to self-agency in patients with schizophrenia. Brain. 2017;140:2226-2239 pubmed publisher
    ..The altered action awareness that characterizes schizophrenia may be due to impaired communication between these areas. ..
  31. Szekely E, Sudre G, Sharp W, Leibenluft E, Shaw P. Defining the Neural Substrate of the Adult Outcome of Childhood ADHD: A Multimodal Neuroimaging Study of Response Inhibition. Am J Psychiatry. 2017;174:867-876 pubmed publisher
    ..Thus, the cortico-cerebellar processes tied to the clinical course of ADHD are separated from the subcortical processes that are not. ..
  32. Khoo H, von Ellenrieder N, Zazubovits N, Dubeau F, Gotman J. Epileptic networks in action: Synchrony between distant hemodynamic responses. Ann Neurol. 2017;82:57-66 pubmed publisher
    ..This also validates the EEG-fMRI approach to reveal this network noninvasively. Ann Neurol 2017;82:57-66. ..
  33. Pistoia F, Sara M, Sacco S, Carolei A. Vegetative states and minimally conscious states revisited: a Russian doll approach. Brain Inj. 2013;27:1330-1 pubmed publisher
  34. Tousseyn S, Krishnan B, Wang Z, Wongwiangjunt S, Nayak C, Mosher J, et al. Connectivity in ictal single photon emission computed tomography perfusion: a cortico-cortical evoked potential study. Brain. 2017;140:1872-1884 pubmed publisher
    ..In trying to understand a patient's epilepsy, one should consider the contribution of all hyperperfused regions, as these are likely not random, but represent an electrically connected epileptic network. ..
  35. Thiel A, Vahdat S. Structural and resting-state brain connectivity of motor networks after stroke. Stroke. 2015;46:296-301 pubmed publisher
  36. Bode S, Murawski C, Soon C, Bode P, Stahl J, Smith P. Demystifying "free will": the role of contextual information and evidence accumulation for predictive brain activity. Neurosci Biobehav Rev. 2014;47:636-45 pubmed
  37. Sommer I, Kahn R. The contribution of neuroimaging to understanding schizophrenia; past, present, and future. Schizophr Bull. 2015;41:1-3 pubmed publisher
  38. Klaus A, Martins G, Paixão V, Zhou P, Paninski L, Costa R. The Spatiotemporal Organization of the Striatum Encodes Action Space. Neuron. 2017;95:1171-1180.e7 pubmed publisher
    ..These results identify a predominantly local, but not spatially compact, organization of direct- and indirect-pathway SPN activity that maps action space independently of movement speed. ..
  39. Baik J. Neurological picture. Isolated cerebellar hemiatrophy related with focal dystonia. J Neurol Neurosurg Psychiatry. 2012;83:948 pubmed publisher
  40. Hsu D, Sanford B, Meyers K, Love T, Hazlett K, Wang H, et al. Social feedback activates the endogenous opioid system. Mol Psychiatry. 2013;18:1147 pubmed publisher
  41. Ko J, Feigin A, Mattis P, Tang C, Ma Y, Dhawan V, et al. Network modulation following sham surgery in Parkinson's disease. J Clin Invest. 2014;124:3656-66 pubmed publisher
    ..Individualized subject selection based on a predetermined network criterion may therefore limit the need for sham interventions in future clinical trials. ..
  42. Formisano R, D Ippolito M, Catani S. Functional locked-in syndrome as recovery phase of vegetative state. Brain Inj. 2013;27:1332 pubmed publisher
  43. Wen S, Cheng M, Cheng M, Yue J, Wang H. Pharmacotherapy response and regional cerebral blood flow characteristics in patients with obsessive-compulsive disorder. Behav Brain Funct. 2013;9:31 pubmed publisher
    ..The characteristics of increased rCBF in forebrain regions and decreased rCBF in posterior brain regions before treatment of OCD patients was a potentially predictor of treatment response to guide treatment options. ..
  44. Aragona M. The Impact of Translational Neuroscience on Revisiting Psychiatric Diagnosis: State of the Art and Conceptual Analysis. Balkan Med J. 2017;34:487-492 pubmed publisher
    ..It is finally suggested that the formation of mental symptoms is a complex process involving both neurocognitive and semantic factors, which raises doubts about the possibility of complete translations, without residuals...
  45. Lueken U, Straube B, Konrad C, Wittchen H, Strohle A, Wittmann A, et al. Neural substrates of treatment response to cognitive-behavioral therapy in panic disorder with agoraphobia. Am J Psychiatry. 2013;170:1345-55 pubmed publisher
    ..Findings point to brain networks by which successful CBT in this patient population is mediated. ..
  46. Stoyanov D, Kandilarova S, Borgwardt S. Translational Functional Neuroimaging in the Explanation of Depression. Balkan Med J. 2017;: pubmed publisher
    ..We will selectively highlight research areas such as imaging genetics, imaging immunology and multimodal imaging related to depression, its diagnosis and management...
  47. Rao H, Wang D, Yang Y, He Y. Neuroimaging of brain networks and function. Biomed Res Int. 2015;2015:509141 pubmed publisher
  48. Allegra Mascaro A, Silvestri L, Sacconi L, Pavone F. Towards a comprehensive understanding of brain machinery by correlative microscopy. J Biomed Opt. 2015;20:61105 pubmed publisher
  49. Conforto A, Chaim K, Peres M, Gonçalves A, Siqueira I, Barreiros M, et al. Interictal abnormal fMRI activation of visual areas during a motor task cued by visual stimuli in migraine. Einstein (Sao Paulo). 2017;15:17-23 pubmed publisher
    ..A privação luminosa não modulou a atividade na ressonância magnética funcional em indivíduos com ou sem enxaqueca. ..
  50. Freyschlag C, Kerschbaumer J, Pinggera D, Bacher G, Mur E, Thome C. Structured Evaluation of Glioma Patients by an Occupational Therapist-Is Our Clinical Examination Enough?. World Neurosurg. 2017;103:493-500 pubmed publisher
    ..Routine clinical examination and neuropsychological evaluation fail to detect mild deficits in sensory function, reactivity, and apraxia, which may have a serious impact on patients' ability to return to their normal lives and work. ..
  51. Pruszynski J, Diedrichsen J. Neuroscience. Reading the mind to move the body. Science. 2015;348:860-1 pubmed publisher
  52. Johnson D, Thom N, Stanley E, Haase L, Simmons A, Shih P, et al. Modifying resilience mechanisms in at-risk individuals: a controlled study of mindfulness training in Marines preparing for deployment. Am J Psychiatry. 2014;171:844-53 pubmed publisher
    ..The results show that mechanisms related to stress recovery can be modified in healthy individuals prior to stress exposure, with important implications for evidence-based mental health research and treatment. ..
  53. Rutledge R, Moutoussis M, Smittenaar P, Zeidman P, Taylor T, Hrynkiewicz L, et al. Association of Neural and Emotional Impacts of Reward Prediction Errors With Major Depression. JAMA Psychiatry. 2017;74:790-797 pubmed publisher
    ..To combine functional neuroimaging, computational modeling, and smartphone-based large-scale data collection to test, in the absence of ..
  54. Hess A, Roesch J, Saake M, Sergeeva M, Hirschmann S, Neumann H, et al. Functional Brain Imaging Reveals Rapid Blockade of Abdominal Pain Response Upon Anti-TNF Therapy in Crohn's Disease. Gastroenterology. 2015;149:864-6 pubmed publisher
  55. Chen C, Tian F, Liu H, Huang J. Diffuse optical tomography enhanced by clustered sparsity for functional brain imaging. IEEE Trans Med Imaging. 2014;33:2323-31 pubmed publisher
    ..An example from human in vivo measurements further confirmed the advantages of the proposed CSR method. ..
  56. Pattinson K. Functional brain imaging in respiratory medicine. Thorax. 2015;70:598-600 pubmed publisher
    ..This article explains how FMRI works, current understanding from FMRI in breathlessness, cough and asthma and suggests possibilities for future research. ..
  57. Chong J, Liu S, Loke Y, Hilal S, Ikram M, Xu X, et al. Influence of cerebrovascular disease on brain networks in prodromal and clinical Alzheimer's disease. Brain. 2017;140:3012-3022 pubmed publisher