first pass ventriculography


Summary: Radionuclide ventriculography where a bolus of radionuclide is injected and data are recorded from one pass through the heart ventricle. Left and right ventricular function can be analyzed independently during this technique. First-pass ventriculography is preferred over GATED BLOOD-POOL IMAGING for assessing right ventricular function.

Top Publications

  1. Kirkpatrick J, Lang R, Fedson S, Anderson A, Bednarz J, Spencer K. Automated border detection on contrast enhanced echocardiographic images. Int J Cardiol. 2005;103:164-7 pubmed
    ..The mean bias was 0.6 with limits of agreement that were +15 and -14. This study demonstrated that prototype software successfully tracked the contrast enhanced endocardial border allowing accurate calculation of LV EF. ..
  2. Kinoshita S, Yamashita S, Suzuki T, Muramatsu T, Ide M, Suzuki S, et al. [Right ventricular volume determination by continuous 81mKr infusion and 99mTc blood pool imaging]. Kaku Igaku. 1992;29:1185-92 pubmed
    ..The RV maximum width was measured as L on the end-diastolic cardiac pool image with 99mTc-D-HSA collected in the 40 degree left anterior oblique position.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  3. Fukuchi K, Hayashida K, Nakanishi N, Inubushi M, Kyotani S, Nagaya N, et al. Quantitative analysis of lung perfusion in patients with primary pulmonary hypertension. J Nucl Med. 2002;43:757-61 pubmed
    ..Quantitative assessment of lung perfusion irregularity might provide useful information about the severity of disease and the effect of therapy in addition to the routine visual representation. ..
  4. Williams K. Measurement of ventricular function with scintigraphic techniques: part I-imaging hardware, radiopharmaceuticals, and first-pass radionuclide angiography. J Nucl Cardiol. 2005;12:86-95 pubmed
  5. Htay T, Mehta D, Sun L, Lacy J, Aqel R, Heo J, et al. Right ventricular pressure-volume loops using simultaneous radionuclide angiography with a multiwire gamma camera and right heart catheterization. J Nucl Cardiol. 2005;12:435-40 pubmed
    ..Such studies could be performed at the bedside and provide a wealth of information that may have clinical and research merits. ..
  6. Bybee K, Kara T. Images in cardiology: Transient left ventricular apical ballooning syndrome. Clin Cardiol. 2005;28:584 pubmed
  7. Galla J, Zakaib J, Callahan T, Askari A. Images in cardiovascular medicine. Iatrogenic left ventricle-to-coronary venous fistula. Circulation. 2006;114:e50 pubmed
  8. Izumi K, Tada S, Yamada T. A case of Takotsubo cardiomyopathy complicated by ventricular septal perforation. Circ J. 2008;72:1540-3 pubmed
    ..The perforation was closed and the patient was discharged 23 days after surgery. This patient had a very rare case of takotsubo cardiomyopathy, which was complicated by ventricular septal perforation and was saved by surgical treatment. ..
  9. Selton Suty C, Juilliere Y. Non-invasive investigations of the right heart: how and why?. Arch Cardiovasc Dis. 2009;102:219-32 pubmed publisher
    ..Finally, all these non-invasive techniques of investigation of the right heart enable the diagnosis of specific right ventricular damage such as myocardial infarction or arrhythmogenic right ventricular dysplasia. ..

More Information


  1. Kramer C, Rogers W, Mankad S, Theobald T, Pakstis D, Hu Y. Contractile reserve and contrast uptake pattern by magnetic resonance imaging and functional recovery after reperfused myocardial infarction. J Am Coll Cardiol. 2000;36:1835-40 pubmed
    ..However, if these regions demonstrate first pass contrast hypoenhancement, they are associated with greater myocardial damage. ..
  2. Oliver R, Fleming J, Waller D. Right ventricular function at rest and during exercise in chronic obstructive pulmonary disease. Comparison of two radionuclide techniques. Chest. 1993;103:74-80 pubmed
    ..In contrast to normal subjects, many show an inability to augment right ventricular function during exercise that may contribute to the reduced exercise capacity observed in these patients. ..
  3. Hartmann A, Frenkel J, Hopf R, Baum R, Hör G, Schneider M, et al. Is technetium-99 m-pyrophosphate scintigraphy valuable in the diagnosis of cardiac amyloidosis?. Int J Card Imaging. 1990;5:227-31 pubmed
    ..Therefore, although cardiac amyloid could not be demonstrated in the static scintigraphy due to amyloid fibril amount and composition, myocardial functional abnormalities were seen in the first-pass study. ..
  4. Hahalis G, Manolis A, Apostolopoulos D, Alexopoulos D, Vagenakis A, Zoumbos N. Right ventricular cardiomyopathy in beta-thalassaemia major. Eur Heart J. 2002;23:147-56 pubmed
    ..The incidence of cor pulmonale as a cause of right heart failure seems to be much lower than previously hypothesized. ..
  5. Lee J, Lee J, Kim S, Kim I, Kim Y, Choo K. Comparison of gated blood pool SPECT and spiral multidetector computed tomography in the assessment of right ventricular functional parameters: validation with first-pass radionuclide angiography. Ann Nucl Med. 2007;21:159-66 pubmed
    ..Also, these results should be confirmed in patients with cardiac diseases in future larger population-based studies. ..
  6. Candell Riera J, Castell Conesa J, Jurado López J, Lopez de Sa E, Nuno de la Rosa J, Ortigosa Aso F, et al. [Nuclear cardiology: technical bases and clinical applications]. Rev Esp Med Nucl. 2000;19:29-64 pubmed
    ..In the second, the indications of them in diagnostic and prognostic evaluation of the different coronary diseases are presented. ..
  7. Wlodarska E, Konka M, Zaleska T, Ploski R, Cedro K, Pucilowska B, et al. Arrhythmogenic right ventricular cardiomyopathy in two pairs of monozygotic twins. Int J Cardiol. 2005;105:126-33 pubmed
    ..No differences in previous viral infections and sports involvement were observed. 1. Clinical picture of ARVC in monozygotic twins is not identical. 2. Strenuous effort may be a factor triggering the arrhythmia in pts with ARVC. ..
  8. Lewis G, Shah R, Pappagianopolas P, Systrom D, Semigran M. Determinants of ventilatory efficiency in heart failure: the role of right ventricular performance and pulmonary vascular tone. Circ Heart Fail. 2008;1:227-33 pubmed publisher
    ..58 and -0.40, respectively, both P<0.05). In patients with systolic heart failure and secondary pulmonary hypertension, ventilatory efficiency is closely related to RV function and pulmonary vascular tone during exercise. ..
  9. Adachi I, Akagi H, Umeda T, Suwa M, Komori T, Ogura Y, et al. Gated blood pool SPECT improves reproducibility of right and left ventricular Fourier phase analysis in radionuclide angiography. Ann Nucl Med. 2003;17:711-6 pubmed
    ..We thus consider GBPS appropriate for evaluating ventricular contractile synchrony. ..
  10. Koelling T, Dec G, Ginns L, Semigran M. Left ventricular diastolic function in patients with advanced cystic fibrosis. Chest. 2003;123:1488-94 pubmed
    ..Patients with cystic fibrosis may be at risk of heart failure due to right ventricular dysfunction or left ventricular diastolic dysfunction. ..
  11. Lum D, Coel M. Comparison of automatic quantification software for the measurement of ventricular volume and ejection fraction in gated myocardial perfusion SPECT. Nucl Med Commun. 2003;24:259-66 pubmed
    ..It may prove prudent for laboratories to independently validate the software algorithm that is chosen against a 'gold standard' using their own population. ..
  12. Lacy J, Layne W, Guidry G, Verani M, Roberts R. Development and clinical performance of an automated, portable tungsten-178/tantalum-178 generator. J Nucl Med. 1991;32:2158-61 pubmed
    ..1 +/- 3.6 microCi. This automated, portable, high-yield 178W/178Ta generator represents a major advancement that will significantly facilitate first-pass radionuclide angiography with 178Ta and the multiwire gamma camera. ..
  13. Lundergan C, Ross A, McCarthy W, Reiner J, Boyle D, Fink C, et al. Predictors of left ventricular function after acute myocardial infarction: effects of time to treatment, patency, and body mass index: the GUSTO-I angiographic experience. Am Heart J. 2001;142:43-50 pubmed
  14. Stallings L, Cheng K, Spicer K, Wiegner R, Humphries J. Ultratag RBC kit for combined cardiac first-pass and multigated acquisition studies. J Nucl Med Technol. 1997;25:44-8 pubmed
    ..5 ml) and a high labeling efficiency that can be used with a single-crystal camera to yield a quality study...
  15. Bartlett M, Seaton D, McEwan L, Fong W. Determination of right ventricular ejection fraction from reprojected gated blood pool SPET: comparison with first-pass ventriculography. Eur J Nucl Med. 2001;28:608-13 pubmed
    ..1 and 7.3 EF units, respectively (P<0.05). Inter-observer variability was comparable in the two techniques (SEE=5.2 and 6.9 EF units for SPET and first-pass ventriculography, respectively). ..
  16. Tausig A, Knesewitsch P, Brinkbäumer K, Tatsch K, Hahn K. Is a low-dose Tc-99m-MIBI protocol suitable for first-pass RNV?. Nucl Med Commun. 2000;21:965-70 pubmed
    ..A minimum of 300 MBq and 4 MBq x (kg body weight)(-1) should be administered in order to obtain technically adequate results even in obese patients. ..
  17. Baik H, Budoff M, Lane K, Bakhsheshi H, Brundage B. Accurate measures of left ventricular ejection fraction using electron beam tomography: a comparison with radionuclide angiography, and cine angiography. Int J Card Imaging. 2000;16:391-8 pubmed
    ..For LVEF < or = 40%, we demonstrated some disparate results between cine angiography and RNA and between EBT and RNA, indicating that CINE or EBT may provide more accurate assessment. ..
  18. Mühling O, Jerosch Herold M, Nabauer M, Wilke N. Assessment of ischemic heart disease using magnetic resonance first-pass perfusion imaging. Herz. 2003;28:82-9 pubmed
    ..The combination gives MRI a unique and strong position in the field of noninvasive diagnostic cardiology. ..
  19. Lacy J, Nanavaty T, Dai D, Nayak N, Haynes N, Martin C. Development and validation of a novel technique for murine first-pass radionuclide angiography with a fast multiwire camera and tantalum 178. J Nucl Cardiol. 2001;8:171-81 pubmed
  20. Kwinecki P, Jemielity M, Czepczyński R, Baszko A, Ruchała M, Sowinski J, et al. Nuclear imaging techniques in the assessment of myocardial perfusion and function after CABG: does it correlate with CK-MB elevation?. Nucl Med Rev Cent East Eur. 2003;6:5-9 pubmed
    ..The increase of CK-MB level early after coronary bypass surgery in patients without ECG markers of perioperative infarction indicates a probable ischaemic insult during surgery. ..
  21. Kosuge M, Kimura K, Ishikawa T, Endo T, Hongo Y, Shigemasa T, et al. ST-segment depression in lead aVR predicts predischarge left ventricular dysfunction in patients with reperfused anterior acute myocardial infarction with anterolateral ST-segment elevation. Am Heart J. 2001;142:51-7 pubmed
    ..We conclude that in patients with an anterolateral AMI, ST-segment depression in lead aVR on admission ECG is useful for predicting larger infarct and left ventricular dysfunction despite successful reperfusion. ..
  22. Jimenez Heffernan A, Aguadé Bruix S, Casáns Tormo I. Nuclear cardiology practice in Spain. J Nucl Cardiol. 2017;24:2133-2140 pubmed publisher
    ..3% first pass ventriculography, and <1% innervation and amyloidosis imaging, respectively...
  23. Barletta G, Baroni M, Del Bene R, Toso A, Fantini F. Regional and temporal nonuniformity of shape and wall movement in the normal left ventricle. Cardiology. 1998;90:195-201 pubmed
    ..Temporal and regional nonuniformity of shape and movement exists in normal subjects. Dyssynchrony between shape and regional contraction of the apical regions deserves further studies. ..
  24. Hacker M, Hoyer X, Kupzyk S, la Fougere C, Kois J, Stempfle H, et al. Clinical validation of the gated blood pool SPECT QBS processing software in congestive heart failure patients: correlation with MUGA, first-pass RNV and 2D-echocardiography. Int J Cardiovasc Imaging. 2006;22:407-16 pubmed
    ..The RVEF calculation method needs to be improved before routine clinical application can be recommended. ..
  25. Kumita S, Seino Y, Cho K, Nakajo H, Toba M, Fukushima Y, et al. Assessment of myocardial washout of Tc-99m-sestamibi in patients with chronic heart failure: comparison with normal control. Ann Nucl Med. 2002;16:237-42 pubmed
    ..01), LVEDV (r = 0.45, p < 0.01) and LVESV (r = 0.48, p < 0.01). The myocardial washout rate of 99Tc-sestamibi is considered to be a novel marker for the diagnosis of myocardial damage in patients with chronic heart failure. ..
  26. Kjaer A, Lebech A, Hesse B, Petersen C. Right-sided cardiac function in healthy volunteers measured by first-pass radionuclide ventriculography and gated blood-pool SPECT: comparison with cine MRI. Clin Physiol Funct Imaging. 2005;25:344-9 pubmed
  27. Strach K, Meyer C, Thomas D, Naehle C, Schmitz C, Litt H, et al. High-resolution myocardial perfusion imaging at 3 T: comparison to 1.5 T in healthy volunteers. Eur Radiol. 2007;17:1829-35 pubmed
    ..5 T. HR myocardial rest perfusion at 3 T is superior to the typical clinical perfusion protocol performed at 1.5 T with respect to the overall image quality and presence of subendocardial dark rim artifacts. ..
  28. Wahba F, Dibbets Schneider P, Bax J, Bavelaar Croon C, Zwinderman A, Pauwels E, et al. Detection of residual wall motion after myocardial infarction by gated technetium-99m tetrofosmin SPET: a comparison with contrast ventriculography. Eur J Nucl Med. 2001;28:514-21 pubmed
    ..Furthermore, in patients with a previous myocardial infarction, gated SPET imaging has the potential to detect preserved wall motion in regions with fixed perfusion defects, which might be indicative of residual myocardial viability. ..
  29. De Bondt P, De Winter O, De Sutter J, Dierckx R. Agreement between four available algorithms to evaluate global systolic left and right ventricular function from tomographic radionuclide ventriculography and comparison with planar imaging. Nucl Med Commun. 2005;26:351-9 pubmed
    ..Volume calculations (for left and right ventricle) and RVEF require further validation before they can be used in clinical practice. ..
  30. Oh J. Evaluation of diastolic function: old and new methods. Rev Port Cardiol. 2001;20 Suppl 1:I17-26 pubmed
    ..With the advent of noninvasive hemodynamic methods, the evaluation of diastolic function can be performed routinely as a part of assessment of cardiac function. ..
  31. Wackers F. On the bright right side. J Nucl Cardiol. 2005;12:378-80 pubmed
  32. Mast S, Shaw L, Ravizzini G, Chambless M, Joski P, Coleman R, et al. Incremental prognostic value of RNA ejection fraction measurements during pharmacologic stress testing: a comparison with clinical and perfusion variables. J Nucl Med. 2001;42:871-7 pubmed
    ..In patients who cannot exercise and are undergoing noninvasive evaluation with pharmacologic stress testing and myocardial perfusion imaging, ejection fraction should be measured simultaneously for risk assessment optimization. ..
  33. Lauerma K, Niemi P, Hanninen H, Janatuinen T, Voipio Pulkki L, Knuuti J, et al. Multimodality MR imaging assessment of myocardial viability: combination of first-pass and late contrast enhancement to wall motion dynamics and comparison with FDG PET-initial experience. Radiology. 2000;217:729-36 pubmed
    ..The combination of first-pass enhancement analysis and wall motion assessment with stress significantly increases the specificity of MR imaging in the detection of unviable sectors. ..
  34. Chang C, Kanno H, Yamamoto I, Kuwana N. Cerebrovascular reactivity to acetazolamide in alert patients with cerebral infarction: usefulness of first-pass radionuclide angiography using 99m Tc-HMPAO in monitoring cerebral haemodynamics. Nucl Med Commun. 2001;22:1119-22 pubmed
  35. Oliver R, Fleming J, Dawkins K, Waller D. Right ventricular function at rest and during submaximal exercise assessed by 81Krm equilibrium ventriculography in normal subjects. Nucl Med Commun. 1993;14:36-40 pubmed
    ..Right heart 81Krm equilibrium ventriculography is well suited to the evaluation of right ventricular function at rest and during exercise. The absolute value of RVEF will however be dependent upon the method of image analysis...
  36. Sadowski J, Wierzbicki K, Wójcik S, Wrobel K. Left ventricular true aneurysm without coronary artery occlusion--a case study. Przegl Lek. 2002;59:190-2 pubmed
    ..Normal coronary angiogram does not exclude development of large true aneurysm of left ventricular wall of typical localization for acute occlusion of left anterior descendent artery. ..
  37. Kjaergaard J, Petersen C, Kjaer A, Schaadt B, Oh J, Hassager C. Evaluation of right ventricular volume and function by 2D and 3D echocardiography compared to MRI. Eur J Echocardiogr. 2006;7:430-8 pubmed
    ..For routine clinical purposes the simple TAPSE may be preferred over 3D and SPECT techniques for RVEF estimation. ..
  38. Yoneyama R, Kawase Y, Hoshino K, McGregor J, Mac Neill B, Lowe H, et al. Magnetic resonance assessment of myocardial perfusion via catheter-based ventricle-coronary vein bypass in porcine myocardial infarction model. Catheter Cardiovasc Interv. 2006;67:58-67 pubmed
    ..VPASS implant with simultaneous AIV and LAD occlusion allows perfusion of oxygenated blood to the distal AIV, which in the setting of an acute myocardial infarction model was capable of rescuing most of the myocardium at risk. ..
  39. Ishiguro M, Hirano T, Watanabe S, Matsuo H, Goto A, Arakawa M. Assessment of right atrial (RA) and right ventricular (RV) function by gated blood pool scan with krypton-81m: RA and RV pressure-volume loops with simultaneous pressure data. Adv Ther. 1991;8:235-42 pubmed
    ..P-V loops of RA and RV were shifted after sublingual nitroglycerin administration. This new method is potentially useful in the study of right heart hemodynamics...
  40. Hoffmann R, von Bardeleben S, ten Cate F, Borges A, Kasprzak J, Firschke C, et al. Assessment of systolic left ventricular function: a multi-centre comparison of cineventriculography, cardiac magnetic resonance imaging, unenhanced and contrast-enhanced echocardiography. Eur Heart J. 2005;26:607-16 pubmed
    ..Inter-observer reliability on EF using contrast echocardiography reaches a level comparable to MRI and is better than those obtained by cineventriculography. ..
  41. Nicol E, Stirrup J, Roughton M, Padley S, Rubens M. 64-Channel cardiac computed tomography: intraobserver and interobserver variability, part 2: global and regional ventricular function, mass, and first pass perfusion. J Comput Assist Tomogr. 2009;33:169-74 pubmed publisher
    ..Right ventricular volumetric and mass data in patients with congenital heart disease should be interpreted with caution. ..
  42. Roncalli J, Carrie D, Fauvel J, Losordo D. A "hawk's beak" to identify the new transient midventricular Tako-Tsubo syndrome. Int J Cardiol. 2008;127:e179-80 pubmed
  43. Lubiszewska B, Gosiewska E, Hoffman P, Teresinska A, Rozanski J, Piotrowski W, et al. Myocardial perfusion and function of the systemic right ventricle in patients after atrial switch procedure for complete transposition: long-term follow-up. J Am Coll Cardiol. 2000;36:1365-70 pubmed
    ..It is likely that myocardial perfusion defects could be a sensitive predictor of systemic ventricular impairment. ..
  44. Tsou S, Sun S, Kao A, Lin C, Lee C. Exercise and rest technetium-99m-tetrofosmin lung uptake: correlation with left ventricular ejection fraction in patients with coronary artery disease. Jpn Heart J. 2002;43:515-22 pubmed
    ..L/H ratios, measured by 99mTc-tetrofosmin imaging, provide clinically useful information with which to predict left ventricular dysfunction in CAD patients. ..
  45. Batyraliev T, Pershukov I, Birand A, Erenler O. Quantitative angiographic analysis of right ventricular global function in normal incidences and in patients with coronary artery disease. Angiology. 2005;56:137-42 pubmed
    ..2887 for patients without CAD and 0.8758+/-0.2232 for patients with CAD. Such calculation is the easiest and quite accurate method of determining RV volumes and function by using existing software of quantitative angiographic analysis. ..
  46. Bensimhon D, Adams G, Whellan D, Pagnanelli R, Trimble M, Lee B, et al. Effect of exercise training on ventricular function, dyssynchrony, resting myocardial perfusion, and clinical outcomes in patients with heart failure: a nuclear ancillary study of Heart Failure and A Controlled Trial Investigating Outcomes of Exercis. Am Heart J. 2007;154:46-53 pubmed
  47. Kjaer A, Lebech A, Gerstoft J, Hesse B, Petersen C. Right ventricular volume and mass determined by cine magnetic resonance imaging in HIV patients with possible right ventricular dysfunction. Angiology. 2006;57:341-6 pubmed
    ..With use of MRI, a few patients with HIV may have a marginally reduced RVEF but normal RV dimensions and mass. Thus, RV dysfunction does not seem to constitute a major clinical problem in this antivirally treated HIV population. ..
  48. Karnati P, El Hajjar M, Torosoff M, Fein S. Myocardial performance index correlates with right ventricular ejection fraction measured by nuclear ventriculography. Echocardiography. 2008;25:381-5 pubmed publisher
    ..25 cm/sec in detecting abnormal RV EF were 100% and 35.4%. MPI greater than 0.50 indicates that RV function is abnormal and a value of PTASV > 17.25 cm/sec indicates normal RV function. ..
  49. Germano G, Erel J, Lewin H, Kavanagh P, Berman D. Automatic quantitation of regional myocardial wall motion and thickening from gated technetium-99m sestamibi myocardial perfusion single-photon emission computed tomography. J Am Coll Cardiol. 1997;30:1360-7 pubmed
    ..929) and thickening (r = 0.959). Our algorithm is accurate and may be the first automatic technique for the quantitative three-dimensional assessment of regional ventricular function in cardiology. ..
  50. Nishi H, Mitsuno M, Ryomoto M, Hao H, Hirota S, Miyamoto Y. Giant cardiac lipoma in the ventricular septum involving the tricuspid valve. Ann Thorac Surg. 2009;88:1337-9 pubmed publisher
    ..As the potential for malignancy was low, tricuspid valve replacement and minimum tumor resection were performed to obtain a suitable route to the right ventricular outflow tract. ..
  51. H Fischer A, van der Loo B, M Shär G, Zbinden R, Duru F, Brunckhorst C, et al. Serological evidence for the association of Bartonella henselae infection with arrhythmogenic right ventricular cardiomyopathy. Clin Cardiol. 2008;31:469-71 pubmed publisher
    ..Bartonella henselae may cause endomyocarditis and was detected in myocardium from a young male who succumbed to sudden cardiac death...
  52. Milles J, van der Geest R, Jerosch Herold M, Reiber J, Lelieveldt B. Fully automated motion correction in first-pass myocardial perfusion MR image sequences. IEEE Trans Med Imaging. 2008;27:1611-21 pubmed publisher
    ..We conclude that this fully automatic ICA-based method shows an accuracy, a robustness and a computation speed adequate for use in a clinical environment. ..
  53. Meinardi M, van Veldhuisen D, Gietema J, Dolsma W, Boomsma F, van den Berg M, et al. Prospective evaluation of early cardiac damage induced by epirubicin-containing adjuvant chemotherapy and locoregional radiotherapy in breast cancer patients. J Clin Oncol. 2001;19:2746-53 pubmed