multimodal imaging


Summary: The use of combination of imaging techniques or platforms (e.g., MRI SCAN and PET SCAN) encompassing aspects of anatomical, functional, or molecular imaging methods.

Top Publications

  1. Miura A, Uemura Y, Takemoto K, Uchikawa T, Koyasu M, Ishikawa S, et al. Early Spontaneous Remission of Intramyocardial Dissecting Hematoma. Intern Med. 2017;56:1067-1070 pubmed publisher
    ..We herein report the first case of a patient with early spontaneous remission of intramyocardial dissecting hematoma successfully managed by a conservative approach with multimodality imaging. ..
  2. Callister M, Baldwin D, Akram A, Barnard S, Cane P, Draffan J, et al. British Thoracic Society guidelines for the investigation and management of pulmonary nodules. Thorax. 2015;70 Suppl 2:ii1-ii54 pubmed publisher
  3. Isilak Z, Kucuk U, Uz O, Yalcin M, Temizkan V. Multimodality Images of a Mixed Atrial Septal Defect. Arq Bras Cardiol. 2016;106:160-1 pubmed publisher
  4. Koers K, Francken A, Haanen J, Woerdeman L, van der Hage J. Vemurafenib as neoadjuvant treatment for unresectable regional metastatic melanoma. J Clin Oncol. 2013;31:e251-3 pubmed publisher
  5. Wang X, Yang F, Jin C, Guan Y, Zhang H, Fu D. The value of 18F-FDG positron emission tomography/computed tomography on the pre-operative staging and the management of patients with pancreatic carcinoma. Hepatogastroenterology. 2014;61:2102-9 pubmed
    ..13%) of unnecessary surgical exploration. FDG-PET/CT is an important staging procedure and helps to make the clinical decision for the patients with pancreatic carcinoma. ..
  6. Fan A, Guo J, Khalighi M, Gulaka P, Shen B, Park J, et al. Long-Delay Arterial Spin Labeling Provides More Accurate Cerebral Blood Flow Measurements in Moyamoya Patients: A Simultaneous Positron Emission Tomography/MRI Study. Stroke. 2017;48:2441-2449 pubmed publisher
    ..Post-label delay times of ≥4 seconds are needed and may be combined with multidelay strategies for robust ASL assessment of CBF in Moyamoya disease. ..
  7. Wu C, Chaudhary K, Na Y, Welch D, Black P, Sonabend A, et al. Quality Assessment of Stereotactic Radiosurgery of a Melanoma Brain Metastases Model Using a Mouselike Phantom and the Small Animal Radiation Research Platform. Int J Radiat Oncol Biol Phys. 2017;99:191-201 pubmed publisher
    ..Single-fraction SRS of 18 Gy delivered in a single arc can be delivered accurately with MRI T1-weighted postcontrast-based treatment planning. The mouse like phantom allows for verification of dose delivery and accuracy. ..
  8. Lee Y, Ramalho J, Kessler B. PET-MR Imaging in Head and Neck. Magn Reson Imaging Clin N Am. 2017;25:315-324 pubmed publisher
    ..Furthermore, advanced MR imaging techniques may also be incorporated to further enhance the diagnostic value of the combined modality. ..
  9. Kim S, Choi M, Kim M, Kim Y, Cho S. Validation of Prostate Imaging Reporting and Data System Version 2 Using an MRI-Ultrasound Fusion Biopsy in Prostate Cancer Diagnosis. AJR Am J Roentgenol. 2017;209:800-805 pubmed publisher
    ..6% (124/131), specificity was 58.7% (204/347), PPV was 51.6% (124/240), and NPV was 85.7% (204/238). PI-RADS version 2 has an overall good performance for the diagnosis of clinically significant prostate cancer. ..

More Information


  1. Seike T, Kagaya T, Komura T, Nakai R, Shimizu Y, Omura H, et al. A rapidly growing, large, mature retroperitoneal teratoma in an adult male patient. Nihon Shokakibyo Gakkai Zasshi. 2017;114:1008-1014 pubmed publisher
    ..The rapid growth of the tumor may have been caused by an increased secretion in the cyst. ..
  2. Xue S, Zhang C, Yang Y, Zhang L, Cheng D, Zhang J, et al. 99mTc-Labeled Iron Oxide Nanoparticles for Dual-Contrast (T1/T2) Magnetic Resonance and Dual-Modality Imaging of Tumor Angiogenesis. J Biomed Nanotechnol. 2015;11:1027-37 pubmed
    ..01). Our study demonstrated that the dual-contrast (T1/T2) magnetic resonance and dual-modal imaging probe based on ultra small superparamagnetic iron oxide nanoparticles is very promising for the molecular imaging of tumor angiogenesis. ..
  3. van der Valk F, Sluimer J, Vöö S, Verberne H, Nederveen A, Windhorst A, et al. In Vivo Imaging of Hypoxia in Atherosclerotic Plaques in Humans. JACC Cardiovasc Imaging. 2015;8:1340-1 pubmed publisher
  4. Madder R, VanOosterhout S, Klungle D, Mulder A, Elmore M, Decker J, et al. Multimodality Intracoronary Imaging With Near-Infrared Spectroscopy and Intravascular Ultrasound in Asymptomatic Individuals With High Calcium Scores. Circ Cardiovasc Imaging. 2017;10: pubmed publisher
    ..This observation may have implications on coronary risk among individuals with a high CACS considering that it is coronary LRP, rather than calcification, that underlies the majority of acute coronary events. ..
  5. Revheim M, Hole K, Bruland O, Reitan E, Bjerkehagen B, Julsrud L, et al. Multimodal functional imaging for early response assessment in GIST patients treated with imatinib. Acta Oncol. 2014;53:143-8 pubmed publisher
  6. Zhu T, Das S, Wong T. Integration of PET/MR Hybrid Imaging into Radiation Therapy Treatment. Magn Reson Imaging Clin N Am. 2017;25:377-430 pubmed publisher
    ..With advances in treatment delivery and the potential of integrating PET/MR imaging with research on radiomics for radiation oncology, quantitative and physiologic information could lead to more precise and personalized RT. ..
  7. Monaco I, Arena F, Biffi S, Locatelli E, Bortot B, La Cava F, et al. Synthesis of Lipophilic Core-Shell Fe3O4@SiO2@Au Nanoparticles and Polymeric Entrapment into Nanomicelles: A Novel Nanosystem for in Vivo Active Targeting and Magnetic Resonance-Photoacoustic Dual Imaging. Bioconjug Chem. 2017;28:1382-1390 pubmed publisher
  8. Chen Y, Ma X, Hua R. Multi-modality imaging findings of huge intrachoroidal cavitation and myopic peripapillary sinkhole. BMC Ophthalmol. 2018;18:24 pubmed publisher
    ..These qualitative and quantitative new findings will be beneficial for understanding its pathomorphological mechanism, and the impact on optic nerve tissue of myopic patients. ..
  9. Godoy M, Truong M, Sabloff B, Naidich D. Subsolid pulmonary nodule management and lung adenocarcinoma classification: state of the art and future trends. Semin Roentgenol. 2013;48:295-307 pubmed publisher
  10. Ohtsubo K, Mouri H, Yamashita K, Makino I, Tajima H, Ohta T, et al. Resection of carcinoma in situ and minimally invasive carcinoma of the pancreas in a patient presenting with stenosis and post-stenotic dilatation of the main pancreatic duct on endoscopic ultrasonography and positive serial pancreatic juice aspirati. Nihon Shokakibyo Gakkai Zasshi. 2017;114:700-709 pubmed publisher
    ..Examination of the distal pancreatectomy specimen demonstrated carcinoma in situ in MPD and branches, with multiple intraepithelial neoplastic lesions in the background pancreas and an additional focus of minimally invasive carcinoma. ..
  11. Artigas C, Alexiou J, Garcia C, Wimana Z, Otte F, Gil T, et al. Paget bone disease demonstrated on (68)Ga-PSMA ligand PET/CT. Eur J Nucl Med Mol Imaging. 2016;43:195-6 pubmed publisher
  12. Bucerius J, Barthel H, Tiepolt S, Werner P, Sluimer J, Wildberger J, et al. Feasibility of in vivo 18F-florbetaben PET/MR imaging of human carotid amyloid-?. Eur J Nucl Med Mol Imaging. 2017;44:1119-1128 pubmed publisher
    ..Male gender was identified as an independent clinical risk factor. Therefore, 18F-florbetaben PET/MRI might provide new insights into the pathophysiological process in atherosclerosis. ..
  13. Chen F, Chew A, Zhang D, Chen S, Chelva E, Chandrasekera E, et al. Acute progressive paravascular placoid neuroretinopathy with negative-type electroretinography in paraneoplastic retinopathy. Doc Ophthalmol. 2017;134:227-235 pubmed publisher
    ..Here we describe the multimodal imaging and clinico-pathological correlation of a unique case of acute progressive paravascular placoid ..
  14. Barber T, Yap K, Kalff V. PET/CT imaging of ??Y radiation synovectomy. Eur J Nucl Med Mol Imaging. 2012;39:917-8 pubmed publisher
  15. Birtel J, Gliem M, Mangold E, Tebbe L, Spier I, Müller P, et al. Novel Insights Into the Phenotypical Spectrum of KIF11-Associated Retinopathy, Including a New Form of Retinal Ciliopathy. Invest Ophthalmol Vis Sci. 2017;58:3950-3959 pubmed publisher
    ..Evaluation of head circumference may be considered as a potential shortcut to the genetic diagnosis. The localization of Kif11 in photoreceptor cells indicates a retinal ciliopathy. ..
  16. Zubizarreta P, Alfaro E, Guitter M, Sanchez La Rosa C, Galluzzo M, Millan N, et al. Children and Adolescent Hodgkin Lymphoma in Argentina: Long-term Results After Combined ABVD and Restricted Radiotherapy. J Pediatr Hematol Oncol. 2017;39:602-608 pubmed publisher
    ..For the HR group, the combination of 6 cycles of ABVD and Low-dose involved field radiotherapy was efficacious with similar good results. Nearly half of the patients could be cured without RT. ..
  17. Soon J, Pibarot P, Blanke P, Ohana M, Leipsic J. Multimodality Imaging for Planning and Follow-up of Transcatheter Aortic Valve Replacement. Can J Cardiol. 2017;33:1110-1123 pubmed publisher
    ..We review the most commonly used imaging modalities and discuss their respective strengths and contributions to optimal patient selection, procedure planning, implementation, and follow-up in TAVR. ..
  18. Sobirov Z, Bakhritdinov F. [Assessment of severity of lesions of arterial basins in patients with multifocal atherosclerosis]. Angiol Sosud Khir. 2017;23:136-141 pubmed
  19. Liu F, Zhu H, Yu J, Han X, Xie Q, Liu T, et al. 68Ga/177Lu-labeled DOTA-TATE shows similar imaging and biodistribution in neuroendocrine tumor model. Tumour Biol. 2017;39:1010428317705519 pubmed publisher
    ..sup>68Ga-DOTA-TATE and 177Lu-DOTA-TATE could accumulate in tumors in animal models, paving the way for better clinical peptide receptor radionuclide therapy for neuroendocrine tumor patients in Asian population. ..
  20. Summer D, Grossrubatscher L, Petrik M, Michalcikova T, Novy Z, Rangger C, et al. Developing Targeted Hybrid Imaging Probes by Chelator Scaffolding. Bioconjug Chem. 2017;28:1722-1733 pubmed publisher
    ..Improvements to fine-tune pharmacokinetics are needed to translate this into a clinical setting...
  21. Tang K, Sui L, Xu G, Zhang T, Liu Q, Liu X. Effects of Different Palliative Jaundice Reducing Methods on Immunologic Functions in Patients with Advanced Malignant Obstructive Jaundice. Anticancer Res. 2017;37:4665-4670 pubmed
    ..The level of serum endotoxin in the group undergoing palliative surgery decreased gradually. Palliative surgery for reducing jaundice is superior to PTCD and ERBD in improving immune function of patients with MOJ. ..
  22. Gorog D, Fayad Z, Fuster V. Arterial Thrombus Stability: Does It Matter and Can We Detect It?. J Am Coll Cardiol. 2017;70:2036-2047 pubmed publisher
    ..Such techniques may allow tailoring of pharmacotherapy to potentiate thrombus instability, through fragmentation of platelet thrombi and/or enhanced endogenous fibrinolysis, to reduce infarct size...
  23. Capuano V, Miere A, Querques L, Sacconi R, Carnevali A, Amoroso F, et al. Treatment-Naïve Quiescent Choroidal Neovascularization in Geographic Atrophy Secondary to Nonexudative Age-Related Macular Degeneration. Am J Ophthalmol. 2017;182:45-55 pubmed publisher
    ..CNV) in geographic atrophy (GA) secondary to nonexudative age-related macular degeneration (AMD) through multimodal imaging. Retrospective observational case series...
  24. McGrath S, Webb A, Walker Bone K. Bleomycin-induced Raynaud's phenomenon after single-dose exposure: risk factors and treatment with intravenous iloprost infusion. J Clin Oncol. 2013;31:e51-2 pubmed publisher
  25. Boellaard R. Mutatis mutandis: harmonize the standard!. J Nucl Med. 2012;53:1-3 pubmed publisher
  26. Strobel K, Wiesmann R, Tornquist K, Steurer Dober I, Muller U. SPECT/CT arthrography of the knee. Eur J Nucl Med Mol Imaging. 2012;39:1975-6 pubmed publisher
  27. Ramalingam W, Nair S, Mandal G. Malignant peripheral nerve sheath tumor of the oral cavity. J Oral Maxillofac Surg. 2012;70:e581-5 pubmed publisher
  28. Chilla S, Zemek O, Kotek J, Boutry S, Larbanoix L, Sclavons C, et al. Synthesis and characterization of monophosphinic acid DOTA derivative: A smart tool with functionalities for multimodal imaging. Bioorg Med Chem. 2017;25:4297-4303 pubmed publisher
    ..The conjugation of Gd-DO2AGAPABn with E3 peptide known to target apoptosis was successfully performed and in vivo MRI allowed cell death detection in a mouse model. ..
  29. Bansal R, Basu S, Gupta A, Rao N, Invernizzi A, Kramer M. Imaging in tuberculosis-associated uveitis. Indian J Ophthalmol. 2017;65:264-270 pubmed publisher
    ..This review enumerates the conventional and emerging imaging techniques for intraocular TB and highlights their clinical application for diagnosis and management of specific clinical presentations. ..
  30. Rischpler C, Maurer T, Schwaiger M, Eiber M. Intense PSMA-expression using (68)Ga-PSMA PET/CT in a paravertebral schwannoma mimicking prostate cancer metastasis. Eur J Nucl Med Mol Imaging. 2016;43:193-4 pubmed publisher
  31. Papadia A, Gasparri M, Genoud S, Bernd K, Mueller M. The combination of preoperative PET/CT and sentinel lymph node biopsy in the surgical management of early-stage cervical cancer. J Cancer Res Clin Oncol. 2017;143:2275-2281 pubmed publisher
    ..PET/CT represents a "safety net" that helps the surgeon in identifying metastatic lymph nodes, especially in patients with larger tumors. ..
  32. Schmidt A, Woedtke T, Stenzel J, Lindner T, Polei S, Vollmar B, et al. One Year Follow-Up Risk Assessment in SKH-1 Mice and Wounds Treated with an Argon Plasma Jet. Int J Mol Sci. 2017;18: pubmed publisher
    ..Our results suggest that the beneficial effects of cold plasma in wound healing come without apparent side effects including tumor formation or chronic inflammation. ..
  33. Wu Z, Yang X, Chen L, Wang Z, Shi Y, Mao H, et al. Anti-angiogenic therapy with contrast-enhanced ultrasound in colorectal cancer patients with liver metastasis. Medicine (Baltimore). 2017;96:e6731 pubmed publisher
    ..002). There were no significant differences in peak intensity and WiAUC between the 2 groups.DCE-US can be used to quantitatively evaluate the hemodynamics of liver metastasis in CRC patients who received bevacizumab-based chemotherapy. ..
  34. Lee N, Yoo D, Ling D, Cho M, Hyeon T, Cheon J. Iron Oxide Based Nanoparticles for Multimodal Imaging and Magnetoresponsive Therapy. Chem Rev. 2015;115:10637-89 pubmed publisher
  35. Glasser M, Coalson T, Robinson E, Hacker C, Harwell J, Yacoub E, et al. A multi-modal parcellation of human cerebral cortex. Nature. 2016;536:171-178 pubmed publisher
  36. Guo J, Tang W, Ye X, Wu H, Xu G, Liu W, et al. Predictive multi-imaging biomarkers relevant for visual acuity in idiopathic macular telangiectasis type 1. BMC Ophthalmol. 2018;18:69 pubmed publisher
    ..associated with visual acuity (VA) in patients with idiopathic macular telangiectasia (MT) type 1 using multimodal imaging modalities...
  37. Kecler Pietrzyk A, Kok H, Lyburn I, Torreggiani W. Dialysis related amyloid arthropathy on ¹?FDG PET-CT. Ulster Med J. 2014;83:117-8 pubmed
  38. Miyashita M, Iwata T, Nakanishi H, Soh J. [Spontaneous Subcapsular Renal Hemorrhage of Papillary Renal Cell Carcinoma]. Hinyokika Kiyo. 2017;63:263-266 pubmed publisher
    ..1%). CT is useful for diagnosis, but it is not highly accurate. Therefore, it is necessary to discuss surgical indication carefully. ..
  39. Reiter T, Werner R, Bauer W, Lapa C. Detection of cardiac sarcoidosis by macrophage-directed somatostatin receptor 2-based positron emission tomography/computed tomography. Eur Heart J. 2015;36:2404 pubmed publisher
  40. Ponte K, Berro D, Collet S, Constans J, Emery E, Valable S, et al. In Vivo Relationship Between Hypoxia and Angiogenesis in Human Glioblastoma: A Multimodal Imaging Study. J Nucl Med. 2017;58:1574-1579 pubmed publisher
    ..This work aimed to study hypoxia and angiogenesis, in vivo and in situ, in patients admitted with GBM using multimodal imaging. Methods: Twenty-three GBM patients were assessed by 18F-fluoromisonidazole (18..
  41. Kong E, Chun K, Cho I. Quantitative assessment of simultaneous F-18 FDG PET/MRI in patients with various types of hepatic tumors: Correlation between glucose metabolism and apparent diffusion coefficient. PLoS ONE. 2017;12:e0180184 pubmed publisher
  42. Hirayama R, Suzuki R, Watanabe T, Matsukawa M, Sakaguchi T, Uekihara K, et al. [Surgical Treatment for Anomalous Aortic Origin of Coronary Arteries]. Kyobu Geka. 2017;70:342-347 pubmed
    ..Repair was accomplished by unroofing the intramural segment. All the cases were successfully treated by surgical treatment. ..
  43. Bhavsar K, Mukkamala L, Freund K. Multimodal imaging in a severe case of hydroxychloroquine toxicity. Ophthalmic Surg Lasers Imaging Retina. 2015;46:377-9 pubmed publisher
    ..Examination and multimodal imaging showed bilateral retinal pigment epithelium (RPE) changes in a bull's-eye distribution associated with ..
  44. Ciardo D, Jereczek Fossa B, Petralia G, Timon G, Zerini D, Cambria R, et al. Multimodal image registration for the identification of dominant intraprostatic lesion in high-precision radiotherapy treatments. Br J Radiol. 2017;90:20170021 pubmed publisher
  45. Hoffman A, Manner H, Rey J, Kiesslich R. A guide to multimodal endoscopy imaging for gastrointestinal malignancy - an early indicator. Nat Rev Gastroenterol Hepatol. 2017;14:421-434 pubmed publisher
    ..Insights into use of multimodal endoscopic imaging for early disease detection, in particular for pre-malignant lesions, in the oesophagus, stomach and colon are described. ..
  46. Chen Y, An H. Attenuation Correction of PET/MR Imaging. Magn Reson Imaging Clin N Am. 2017;25:245-255 pubmed publisher
    ..In this article, we review atlas and direct imaging MR-based PET attenuation correction methods. The technical principles behind these methods are detailed and the advantages and disadvantages of these methods are discussed. ..
  47. Lau J, Laforest R, Nensa F, Zheng J, Gropler R, Woodard P. Cardiac Applications of PET/MR Imaging. Magn Reson Imaging Clin N Am. 2017;25:325-333 pubmed publisher
    ..In this article, the authors start with a discussion of the technical challenges specific to cardiovascular PET/MR imaging followed by a discussion of the use of PET/MR imaging in various cardiovascular conditions. ..
  48. Liu S, Liu S, Cai W, Che H, Pujol S, Kikinis R, et al. Multimodal neuroimaging feature learning for multiclass diagnosis of Alzheimer's disease. IEEE Trans Biomed Eng. 2015;62:1132-40 pubmed publisher
    ..A performance gain was achieved in both binary classification and multiclass classification of AD. The advantages and limitations of the proposed framework are discussed. ..
  49. Lalush D. Magnetic Resonance-Derived Improvements in PET Imaging. Magn Reson Imaging Clin N Am. 2017;25:257-272 pubmed publisher
    ..Evaluation in clinical applications is needed to determine their true impacts. ..
  50. Varadhachary G, Raber M. Cancer of unknown primary site. N Engl J Med. 2014;371:757-65 pubmed publisher
  51. Chang Y, Kemmotsu N, Leyden K, Kucukboyaci N, Iragui V, Tecoma E, et al. Multimodal imaging of language reorganization in patients with left temporal lobe epilepsy. Brain Lang. 2017;170:82-92 pubmed publisher
    This study explored the relationships among multimodal imaging, clinical features, and language impairment in patients with left temporal lobe epilepsy (LTLE)...
  52. Jadvar H. Targeted Radionuclide Therapy: An Evolution Toward Precision Cancer Treatment. AJR Am J Roentgenol. 2017;209:277-288 pubmed publisher the understanding of the complex underlying biology of cancer and advances in radiochemistry science, multimodal imaging techniques including the concept of "see and treat" within the framework of theranostics, and ..
  53. Berti V, Mosconi L, Pupi A. Brain: normal variations and benign findings in fluorodeoxyglucose-PET/computed tomography imaging. PET Clin. 2014;9:129-40 pubmed
    ..The effect of different substances, medications, and therapy procedures are discussed, as well as common artifacts. ..