myocardial perfusion imaging


Summary: The creation and display of functional images showing where the blood is flowing into the MYOCARDIUM by following over time the distribution of tracers injected into the blood stream.

Top Publications

  1. Kobayashi S, Makino K, Hatakeyama S, Ishii T, Tateno M, Iwamoto T, et al. The usefulness of combined brain perfusion single-photon emission computed tomography, Dopamine-transporter single-photon emission computed tomography, and 123 I-metaiodobenzylguanidine myocardial scintigraphy for the diagnosis of dementia with Lewy . Psychogeriatrics. 2017;17:247-255 pubmed publisher
    ..However, our results suggest that the combination of bp-SPECT, MIBG scintigraphy, and DAT-SPECT increased the accuracy of the clinical diagnosis of DLB. ..
  2. Brunken R. Promising New 18F-Labeled Tracers for PET Myocardial Perfusion Imaging. J Nucl Med. 2015;56:1478-9 pubmed publisher
  3. Neglia D, Rovai D, Caselli C, Pietilä M, Teresinska A, Aguadé Bruix S, et al. Detection of significant coronary artery disease by noninvasive anatomical and functional imaging. Circ Cardiovasc Imaging. 2015;8: pubmed publisher
    ..pain and intermediate likelihood of CAD underwent coronary computed tomographic angiography and stress myocardial perfusion imaging by single photon emission computed tomography or positron emission tomography, and ventricular wall ..
  4. Ismail T, Hsu L, Greve A, Goncalves C, Jabbour A, Gulati A, et al. Coronary microvascular ischemia in hypertrophic cardiomyopathy - a pixel-wise quantitative cardiovascular magnetic resonance perfusion study. J Cardiovasc Magn Reson. 2014;16:49 pubmed publisher
    ..086, 95% CI: 0.078 to 0.095, P=0.003). Pixel-wise quantitative CMR perfusion imaging identifies a subgroup of patients with HCM that have localised severe microvascular dysfunction which may give rise to myocardial ischemia. ..
  5. Rossi A, Wragg A, Klotz E, Pirro F, Moon J, Nieman K, et al. Dynamic Computed Tomography Myocardial Perfusion Imaging: Comparison of Clinical Analysis Methods for the Detection of Vessel-Specific Ischemia. Circ Cardiovasc Imaging. 2017;10: pubmed publisher
    The clinical analysis of myocardial dynamic computed tomography myocardial perfusion imaging lacks standardization...
  6. Gan L, Svedlund S, Wittfeldt A, Eklund C, Gao S, Matejka G, et al. Incremental Value of Transthoracic Doppler Echocardiography-Assessed Coronary Flow Reserve in Patients With Suspected Myocardial Ischemia Undergoing Myocardial Perfusion Scintigraphy. J Am Heart Assoc. 2017;6: pubmed publisher
    ..The current study supports routine assessment of CFR in patients with suspected ischemic heart disease. ..
  7. Davies M, Newton J. Non-invasive imaging in cardiology for the generalist. Br J Hosp Med (Lond). 2017;78:392-398 pubmed publisher
    ..It discusses the strengths of each imaging technique, in which circumstances it is most useful and its diagnostic accuracy. ..
  8. Nakajima K, Okuda K, Momose M, Matsuo S, Kondo C, Sarai M, et al. IQ·SPECT technology and its clinical applications using multicenter normal databases. Ann Nucl Med. 2017;31:649-659 pubmed publisher
    ..Recent reports regarding its technology, Japanese Society of Nuclear Medicine working group activities, and clinical studies using 201Tl and 99mTc-perfusion tracers in Japan are summarized. ..
  9. Westergren H, Michaëlsson E, Blomster J, Miliotis T, Svedlund S, Gan L. Determinants of coronary flow reserve in non-diabetic patients with chest pain without myocardial perfusion defects. PLoS ONE. 2017;12:e0176511 pubmed publisher
    ..Insulin resistance appears to be a marker for decreased CFR in men. Indeed, in the context of contribution of traditional risk factors in this patient population, the value of systolic blood pressure seems to be important in the women. ..

More Information


  1. Depuey E, Mahmarian J, Miller T, Einstein A, Hansen C, Holly T, et al. Patient-centered imaging. J Nucl Cardiol. 2012;19:185-215 pubmed publisher
  2. Chen Z, Wang G, Liang L, Lu X, Guo Q, Zhai Y, et al. [Determination of iodine content in the left ventricular myocardium of healthy subjects using dual-source dual-energy CT myocardial first perfusion imaging: a preliminary study]. Zhonghua Xin Xue Guan Bing Za Zhi. 2017;45:415-418 pubmed publisher
    ..07?0.27±0.06?0.28±0.08?0.28±0.07?0.29±0.08?0.31±0.07?0.27±0.06?0.29±0.06?0.21±0.07????17??nic?????????????????????(p?<0.05)????????????????(p?>0.05)? ??? ????????????????3.1?7.8 mg/ml??????????????. ..
  3. Hendel R, Abbott B, Bateman T, Blankstein R, Calnon D, Leppo J, et al. The role of radionuclide myocardial perfusion imaging for asymptomatic individuals. J Nucl Cardiol. 2011;18:3-15 pubmed publisher
  4. Ziadi M, Beanlands R. The clinical utility of assessing myocardial blood flow using positron emission tomography. J Nucl Cardiol. 2010;17:571-81 pubmed publisher
  5. Beller G, Watson D. A welcomed new myocardial perfusion imaging agent for positron emission tomography. Circulation. 2009;119:2299-301 pubmed publisher
  6. Yusuf S, Durand J, Lenihan D, Swafford J. Dextrocardia: an incidental finding. Tex Heart Inst J. 2009;36:358-9 pubmed
  7. Beller G, Ragosta M. Decision making in multivessel coronary disease: the need for physiological lesion assessment. JACC Cardiovasc Interv. 2010;3:315-7 pubmed publisher
  8. Klein R, Beanlands R, dekemp R. Quantification of myocardial blood flow and flow reserve: Technical aspects. J Nucl Cardiol. 2010;17:555-70 pubmed publisher
  9. Kurisu S, Sumimoto Y, Ikenaga H, Ishibashi K, Fukuda Y, Kihara Y. Effects of chronic kidney disease on myocardial washout rate of thallium-201 in patients with normal myocardial perfusion on single photon emission computed tomography. Ann Nucl Med. 2017;31:703-708 pubmed publisher
    ..24, p?=?0.002) were the major determinants of myocardial WR of Tl-201, but hemodialysis was not. Our data suggest that CKD is associated with increased myocardial WR of Tl-201 in patients with normal perfusion on SPECT. ..
  10. Saraste A, Knuuti J. Dynamic perfusion CT: what is normal myocardial blood flow?. Eur Heart J Cardiovasc Imaging. 2015;16:288-9 pubmed publisher
  11. Schindler T, Dilsizian V. PET-determined hyperemic myocardial blood flow: further progress to clinical application. J Am Coll Cardiol. 2014;64:1476-8 pubmed publisher
  12. Wang J, Xiang B, Deng J, Lin H, Freed D, Arora R, et al. Preservation of Myocardial Perfusion and Function by Keeping Hypertrophied Heart Empty and Beating for Valve Surgery: An In Vivo MR Study of Pig Hearts. Biomed Res Int. 2017;2017:4107587 pubmed publisher
    ..6 ± 7.2 days after ascending aorta banding underwent NNBP and NHCA, respectively. Near infrared myocardial perfusion imaging with indocyanine green (ICG) was conducted to assess myocardial perfusion...
  13. Sethi P, Panchal H, Veeranki S, Ur Rahman Z, Mamudu H, Paul T. Diagnostic Value of Noninvasive Computed Tomography Perfusion Imaging and Coronary Computed Tomography Angiography for Assessing Hemodynamically Significant Native Coronary Artery Lesions. Am J Med Sci. 2017;354:291-298 pubmed publisher
    ..93-9.43), 0.209 (CI: 0.12-0.36), and 31.97 (CI: 11.59-88.20). This result suggests that CTP with CTA significantly improves diagnostic performance of coronary artery lesions compared to CTA alone and closely comparable with invasive FFR. ..
  14. Alsamarah A, Bansari A, Nasser H, Raza W, Alsamarah I, Bagrova A, et al. Comparison of the Appropriateness of Myocardial Perfusion Imaging in Men Versus Women. Am J Cardiol. 2017;120:191-195 pubmed publisher
    ..maybe appropriate, and rarely appropriate) and cardiovascular outcomes in patients undergoing nuclear myocardial perfusion imaging (MPI) between June 2011 and September 2014 in predominantly inpatient setting...
  15. Pelgrim G, van Hamersvelt R, Willemink M, Schmidt B, Flohr T, Schilham A, et al. Accuracy of iodine quantification using dual energy CT in latest generation dual source and dual layer CT. Eur Radiol. 2017;27:3904-3912 pubmed publisher
    ..Lowest measurement error was found in scans with largest photon energy separation. • Dual-source CT quantified iodine slightly more accurately than dual layer CT. ..
  16. Carpeggiani C, Picano E, Brambilla M, Michelassi C, Knuuti J, Kauffman P, et al. Variability of radiation doses of cardiac diagnostic imaging tests: the RADIO-EVINCI study (RADIationdOse subproject of the EVINCI study). BMC Cardiovasc Disord. 2017;17:63 pubmed publisher
    ..significant radiation dose through repeated exposures to coronary computed tomographic angiography, myocardial perfusion imaging with single photon emission computed tomography or positron emission tomography, and to invasive ..
  17. Salerno M, Beller G. Noninvasive assessment of myocardial perfusion. Circ Cardiovasc Imaging. 2009;2:412-24 pubmed publisher
  18. Nudi F, Schillaci O, Di Belardino N, Versaci F, Tomai F, Pinto A, et al. Temporal Trends in the Prevalence, Severity, and Localization of Myocardial Ischemia and Necrosis at Myocardial Perfusion Imaging After Myocardial Infarction. Am J Cardiol. 2017;120:1238-1244 pubmed publisher
    ..Whether these changes have impacted on the presence, severity, and localization of necrosis at myocardial perfusion imaging (MPI) has not been appraised to date...
  19. Williams M, Newby D. CT myocardial perfusion: a step towards quantification. Heart. 2012;98:521-2 pubmed publisher
  20. Engbers E, Timmer J, Mouden M, Knollema S, Jager P, Ottervanger J. Prognostic Value of Myocardial Perfusion Imaging with a Cadmium-Zinc-Telluride SPECT Camera in Patients Suspected of Having Coronary Artery Disease. J Nucl Med. 2017;58:1459-1463 pubmed publisher
    The prognostic value of myocardial perfusion imaging (MPI) with the cadmium-zinc-telluride (CZT) SPECT camera is not well established...
  21. Nielles Vallespin S, Khalique Z, Ferreira P, de Silva R, Scott A, Kilner P, et al. Assessment of Myocardial Microstructural Dynamics by In Vivo Diffusion Tensor Cardiac Magnetic Resonance. J Am Coll Cardiol. 2017;69:661-676 pubmed publisher
    ..These novel insights significantly improve understanding of contractile dysfunction at a level of noninvasive interrogation not previously available in humans. ..
  22. Chung H, Ko S, Hwang H, So Y, Yi J, Lee E. Diagnostic Performance of Coronary CT Angiography, Stress Dual-Energy CT Perfusion, and Stress Perfusion Single-Photon Emission Computed Tomography for Coronary Artery Disease: Comparison with Combined Invasive Coronary Angiography and Stress Perfusi. Korean J Radiol. 2017;18:476-486 pubmed publisher
    ..stress perfusion single-photon emission computed tomography (SPECT), and the combinations of CCTA with myocardial perfusion imaging (CCTA + DE-CTP and CCTA + SPECT) for identifying coronary artery stenosis that causes myocardial ..
  23. Petretta M, Cuocolo A. Screening asymptomatic patients with type 2 diabetes is recommended: Pro. J Nucl Cardiol. 2015;22:1225-8 pubmed publisher
  24. Chen M, Lo H, Su H, Chao I. Coronary artery fistula: assessment with multidetector computed tomography and stress myocardial single photon emission computed tomography. Clin Nucl Med. 2009;34:96-8 pubmed publisher
  25. Kern M. Basal stenosis resistance: another adenosine-free contender for the lesion assessment crown?. Circ Cardiovasc Interv. 2012;5:456-8 pubmed publisher
  26. Plein S, Motwani M. Fractional flow reserve as the reference standard for myocardial perfusion studies: fool's gold?. Eur Heart J Cardiovasc Imaging. 2013;14:1211-3 pubmed publisher
  27. Agostini D, Carrio I, Verberne H. How to use myocardial 123I-MIBG scintigraphy in chronic heart failure. Eur J Nucl Med Mol Imaging. 2009;36:555-9 pubmed publisher
  28. Henzlova M, Duvall W. The future of SPECT MPI: time and dose reduction. J Nucl Cardiol. 2011;18:580-7 pubmed publisher
  29. Marwick T. Consistency of myocardial deformation imaging between vendors. Eur J Echocardiogr. 2010;11:414-6 pubmed publisher
    ..The implications of these findings for the clinical application of strain are discussed. ..
  30. Bengel F. Leaving relativity behind: quantitative clinical perfusion imaging. J Am Coll Cardiol. 2011;58:749-51 pubmed publisher
  31. Hage F. Regadenoson for myocardial perfusion imaging: Is it safe?. J Nucl Cardiol. 2014;21:871-6 pubmed publisher
  32. Holly T, Abbott B, Al Mallah M, Calnon D, Cohen M, DiFilippo F, et al. Single photon-emission computed tomography. J Nucl Cardiol. 2010;17:941-73 pubmed publisher
  33. Feher A, Sinusas A. Quantitative Assessment of Coronary Microvascular Function: Dynamic Single-Photon Emission Computed Tomography, Positron Emission Tomography, Ultrasound, Computed Tomography, and Magnetic Resonance Imaging. Circ Cardiovasc Imaging. 2017;10: pubmed publisher
  34. Anagnostopoulos C, Neill J, Reyes E, Prvulovich E. Myocardial perfusion scintigraphy: technical innovations and evolving clinical applications. Heart. 2012;98:353-9 pubmed publisher
  35. Al Mallah M, Sitek A, Moore S, Di Carli M, Dorbala S. Assessment of myocardial perfusion and function with PET and PET/CT. J Nucl Cardiol. 2010;17:498-513 pubmed publisher
  36. Bailey G, Healy A, Young B, Sharma E, Meadows J, Chun H, et al. Relative predictive value of lung cancer screening CT versus myocardial perfusion attenuation correction CT in the evaluation of coronary calcium. PLoS ONE. 2017;12:e0175678 pubmed publisher
    ..It is therefore reasonable to use LCSCT images to derive and report Agatston-based CACS for cardiovascular risk assessment, whereas the use of ACCT images to report Agatston-based CACS is not currently practical. ..
  37. Takahashi K, Takeuchi T, Hosokai Y, Odagiri H, Saito H. Motion-frozen Imaging by Gated Myocardial Perfusion Single Photon Emission Computed Tomography Using Multi-focus Fan Beam Collimator in Thallium-201 Study. Nihon Hoshasen Gijutsu Gakkai Zasshi. 2017;73:282-290 pubmed publisher
    ..The results of this MF image with IQ · SPECT study suggest that the optimal acquisition parameter should be 56 beats/view in 8 frames per R-R interval, and the optimal reconstruction parameters should be subset 3 and iteration 14. ..
  38. Lee J, Hwang D, Park J, Zhang J, Tong Y, Kim C, et al. Exploring Coronary Circulatory Response to Stenosis and Its Association With Invasive Physiologic Indexes Using Absolute Myocardial Blood Flow and Coronary Pressure. Circulation. 2017;136:1798-1808 pubmed publisher
    ..URL: Unique identifier: NCT01366404. ..
  39. Hendel R, Frost L. Off-label, but on-target: use of regadenoson with exercise. J Nucl Cardiol. 2013;20:179-81 pubmed publisher
  40. Gaemperli O, Kaufmann P, Alkadhi H. Cardiac hybrid imaging. Eur J Nucl Med Mol Imaging. 2014;41 Suppl 1:S91-103 pubmed
  41. Caobelli F, Haaf P, Chronis J, Haenny G, Brinkert M, Pfisterer M, et al. Prognostic Usefulness of Cardiac Stress Test Modalities in Patients With Type 2 Diabetes Mellitus Who Underwent Myocardial Perfusion Scintigraphy (from the Basel Asymptomatic High-Risk Diabetics' Outcome Trial). Am J Cardiol. 2017;120:1098-1103 pubmed publisher
    ..MPS provided an incremental prognostic value in pharmacological patients and in patients with <6METs. In contrast, patients who were able to achieve ?6 METs were at low risk and do not need further risk stratification. ..
  42. McNulty E, Hung Y, Almers L, Go A, Yeh R. Population trends from 2000-2011 in nuclear myocardial perfusion imaging use. JAMA. 2014;311:1248-9 pubmed publisher
  43. Cuocolo A. Attenuation correction for myocardial perfusion SPECT imaging: still a controversial issue. Eur J Nucl Med Mol Imaging. 2011;38:1887-9 pubmed publisher
  44. Min J, Shaw L. Noninvasive diagnostic and prognostic assessment of individuals with suspected coronary artery disease: coronary computed tomographic angiography perspective. Circ Cardiovasc Imaging. 2008;1:270-81; discussion 281 pubmed publisher
  45. Salerno M, Sharif B, Arheden H, Kumar A, Axel L, Li D, et al. Recent Advances in Cardiovascular Magnetic Resonance: Techniques and Applications. Circ Cardiovasc Imaging. 2017;10: pubmed publisher
    ..This review will highlight some recent novel cardiovascular magnetic resonance imaging techniques, concepts, and applications. ..
  46. Orimo S. New development of diagnosis and treatment for Parkinson's disease. Rinsho Shinkeigaku. 2017;57:259-273 pubmed publisher
  47. Smith Bindman R, Bindman A. Imaging More Wisely. JAMA Intern Med. 2016;176:168-70 pubmed publisher
  48. Shaw L, Hage F, Berman D, Hachamovitch R, Iskandrian A. Prognosis in the era of comparative effectiveness research: where is nuclear cardiology now and where should it be?. J Nucl Cardiol. 2012;19:1026-43 pubmed publisher
  49. Gulsin G, Shetye A, Khoo J, Swarbrick D, Levelt E, Lai F, et al. Does stress perfusion imaging improve the diagnostic accuracy of late gadolinium enhanced cardiac magnetic resonance for establishing the etiology of heart failure?. BMC Cardiovasc Disord. 2017;17:98 pubmed publisher
    ..CMR first-pass myocardial perfusion imaging (perfusion-CMR) may also play role in distinguishing heart failure of ischemic and non-ischemic origins,..
  50. Takanashi M, Li Y, Hattori N. Absence of Lewy pathology associated with PINK1 homozygous mutation. Neurology. 2016;86:2212-3 pubmed publisher
  51. Jouni H, Askew J, Crusan D, Miller T, Gibbons R. Temporal Trends of Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging in Patients With Coronary Artery Disease: A 22-Year Experience From a Tertiary Academic Medical Center. Circ Cardiovasc Imaging. 2017;10: pubmed publisher
    ..gradual decline in the prevalence of abnormal stress single-photon emission computed tomography (SPECT) myocardial perfusion imaging studies among patients without history of coronary artery disease (CAD)...
  52. Durante A, Laricchia A, Benedetti G, Esposito A, Margonato A, Rimoldi O, et al. Identification of High-Risk Patients After ST-Segment-Elevation Myocardial Infarction: Comparison Between Angiographic and Magnetic Resonance Parameters. Circ Cardiovasc Imaging. 2017;10:e005841 pubmed publisher
    ..Another novel finding of our study is a significantly increased rate of clinically driven target lesion revascularization in the index event culprit vessel in patients with MVO. ..
  53. Padilha B, Sabino D, Giorgi M, Soares J, Izaki M, Meneghetti J. Case Report: Multivessel Coronary Disease Assessment with SPECT 99mTc-Sestamibi and Rubidium-82 PET/CT. Arq Bras Cardiol. 2017;108:87-90 pubmed publisher