Summary: The determination of the nature of a disease or condition, or the distinguishing of one disease or condition from another. Assessment may be made through physical examination, laboratory tests, or the likes. Computerized programs may be used to enhance the decision-making process.

Top Publications

  1. Lebrilla C, An H. The prospects of glycan biomarkers for the diagnosis of diseases. Mol Biosyst. 2009;5:17-20 pubmed publisher
    ..This opinion article argues the intrinsic advantages of using glycans as disease markers over other biomolecules and the potential of glycan profiling for diagnosing and determining the progression of disease. ..
  2. Lu A, Bian Z, Chen K. Bridging the traditional Chinese medicine pattern classification and biomedical disease diagnosis with systems biology. Chin J Integr Med. 2012;18:883-90 pubmed publisher
    ..In this article, the authors integrated the pattern classification and disease diagnosis with many approaches from systems biology...
  3. Li K, Chen P, Wang S. An intelligent diagnosis method for rotating machinery using least squares mapping and a fuzzy neural network. Sensors (Basel). 2012;12:5919-39 pubmed publisher
    This study proposes a new condition diagnosis method for rotating machinery developed using least squares mapping (LSM) and a fuzzy neural network...
  4. Alkner S, Bendahl P, Fernö M, Manjer J, Rydén L. Prediction of outcome after diagnosis of metachronous contralateral breast cancer. BMC Cancer. 2011;11:114 pubmed publisher
    ..examinations had a significantly lower risk of developing metastases compared to those who were symptomatic at diagnosis (p < 0.0001)...
  5. Welch H, Sharp S, Gottlieb D, Skinner J, Wennberg J. Geographic variation in diagnosis frequency and risk of death among Medicare beneficiaries. JAMA. 2011;305:1113-8 pubmed publisher
    Because diagnosis is typically thought of as purely a patient attribute, it is considered a critical factor in risk-adjustment policies designed to reward efficient and high-quality care...
  6. Shi S, Shi Y, Taylor C. Antigen retrieval immunohistochemistry: review and future prospects in research and diagnosis over two decades. J Histochem Cytochem. 2011;59:13-32 pubmed publisher
    ..of many different investigators have coalesced in extending the AR approach to all areas of anatomic pathology diagnosis and research and further have led to AR-based protein extraction techniques and tissue-based proteomics...
  7. Kassirer J. Teaching clinical reasoning: case-based and coached. Acad Med. 2010;85:1118-24 pubmed
    Optimal medical care is critically dependent on clinicians' skills to make the right diagnosis and to recommend the most appropriate therapy, and acquiring such reasoning skills is a key requirement at every level of medical education...
  8. Stolper E, van Leeuwen Y, Van Royen P, Van de Wiel M, van Bokhoven M, Houben P, et al. Establishing a European research agenda on 'gut feelings' in general practice. A qualitative study using the nominal group technique. Eur J Gen Pract. 2010;16:75-9 pubmed publisher
    ..Furthermore, two experimental designs were proposed. A European research agenda on 'gut feelings' in general practice has been established and could be used in collaborative research. ..
  9. Candia J, Maunu R, Driscoll M, Biancotto A, Dagur P, McCoy J, et al. From cellular characteristics to disease diagnosis: uncovering phenotypes with supercells. PLoS Comput Biol. 2013;9:e1003215 pubmed publisher
    ..We apply our approach to two kinds of single-cell datasets, addressing the diagnosis of a premature aging disorder using images of cell nuclei, as well as the phenotypes of two non-infectious ..

More Information


  1. Stolper E, van Bokhoven M, Houben P, Van Royen P, van de Wiel M, van der Weijden T, et al. The diagnostic role of gut feelings in general practice. A focus group study of the concept and its determinants. BMC Fam Pract. 2009;10:17 pubmed publisher
    ..In the former case, a GP is sure about prognosis and therapy, although they may not always have a clear diagnosis in mind...
  2. Pileggi R, O Neill P. Team-based learning using an audience response system: an innovative method of teaching diagnosis to undergraduate dental students. J Dent Educ. 2008;72:1182-8 pubmed
    ..9 percent). Students also exhibited improved diagnostic skills with the final examination. The results of the students' attitudinal survey indicated an 80 percent agreement that TBL enhanced their powers of critical analysis. ..
  3. Vickers A, Basch E, Kattan M. Against diagnosis. Ann Intern Med. 2008;149:200-3 pubmed
    The act of diagnosis requires that patients be placed in a binary category of either having or not having a certain disease...
  4. Stolper E, Van Royen P, van de Wiel M, van Bokhoven M, Houben P, van der Weijden T, et al. Consensus on gut feelings in general practice. BMC Fam Pract. 2009;10:66 pubmed publisher
    ..the further management and course of a patient's problem, even though the doctor may not be certain about the diagnosis: Everything fits in. The sense of alarm and the sense of reassurance are well-defined concepts...
  5. Quinn P, Rainteau D, Wolf C. Lipidomics of the red cell in diagnosis of human disorders. Methods Mol Biol. 2009;579:127-59 pubmed publisher
    ..Both methods have been evaluated and have been shown to be suitable for diagnosis and/or monitoring for a variety of human disorders.
  6. Street A. Artefacts of not-knowing: the medical record, the diagnosis and the production of uncertainty in Papua New Guinean biomedicine. Soc Stud Sci. 2011;41:815-34 pubmed
    ..Practices of not-knowing and knowing are therefore shown to be interdependent and interchangeable 'moments' of bureaucratic-biomedical work. ..
  7. Vikström A, Nyström M, Ahlfeldt H, Strender L, Nilsson G. Views of diagnosis distribution in primary care in 2.5 million encounters in Stockholm: a comparison between ICD-10 and SNOMED CT. Inform Prim Care. 2010;18:17-29 pubmed
    ..A broader use of SNOMED CT is therefore of importance when describing and developing primary care. ..
  8. Gerard N. A diagnosis of conflict: theoretical barriers to integration in mental health services & their philosophical undercurrents. Philos Ethics Humanit Med. 2010;5:4 pubmed publisher
    ..By exposing this underlying framework--and the motivations inherent therein--the topic of integration appears in wholly different light, allowing a renewed philosophical basis for integration to emerge. ..
  9. Edelman L, Toia G, Geman D, Zhang W, Price N. Two-transcript gene expression classifiers in the diagnosis and prognosis of human diseases. BMC Genomics. 2009;10:583 pubmed publisher
    ..The experimental simplicity of this method results in measurements that can be easily translated to clinical practice. ..
  10. Ozcift A, Gulten A. Classifier ensemble construction with rotation forest to improve medical diagnosis performance of machine learning algorithms. Comput Methods Programs Biomed. 2011;104:443-51 pubmed publisher
    Improving accuracies of machine learning algorithms is vital in designing high performance computer-aided diagnosis (CADx) systems...
  11. Vahtera J, Westerlund H, Ferrie J, Head J, Melchior M, Singh Manoux A, et al. All-cause and diagnosis-specific sickness absence as a predictor of sustained suboptimal health: a 14-year follow-up in the GAZEL cohort. J Epidemiol Community Health. 2010;64:311-7 pubmed publisher
    ..The aim of this study was to investigate overall and diagnosis-specific sickness absences as predictors of sustained suboptimal health...
  12. Schunemann H, Oxman A, Brozek J, Glasziou P, Bossuyt P, Chang S, et al. GRADE: assessing the quality of evidence for diagnostic recommendations. Evid Based Med. 2008;13:162-3 pubmed publisher
  13. Peng G, Tisch U, Haick H. Detection of nonpolar molecules by means of carrier scattering in random networks of carbon nanotubes: toward diagnosis of diseases via breath samples. Nano Lett. 2009;9:1362-8 pubmed publisher
    ..As examples for the technological impact of our findings, we describe ways to detect lung cancer and kidney disease using specially designed RN-CNT sensor arrays. ..
  14. Harrison G, Escobar G. Length of stay and imminent discharge probability distributions from multistage models: variation by diagnosis, severity of illness, and hospital. Health Care Manag Sci. 2010;13:268-79 pubmed
    ..Our study objective was to determine whether such models could be used for patient groups restricted by diagnosis, severity of illness, or hospital in order to facilitate comparisons conditioned on these factors...
  15. Scepanovic O, Volynskaya Z, Kong C, Galindo L, Dasari R, Feld M. A multimodal spectroscopy system for real-time disease diagnosis. Rev Sci Instrum. 2009;80:043103 pubmed publisher
    ..As such, MMS is a promising tool for disease diagnosis, particularly in atherosclerosis and breast cancer...
  16. Lima M, Nogueira R, Schatzmayr H, de Filippis A, Limonta D, dos Santos F. A new approach to dengue fatal cases diagnosis: NS1 antigen capture in tissues. PLoS Negl Trop Dis. 2011;5:e1147 pubmed publisher
    ..The overall dengue fatal case diagnosis based on the tissues analyzed by Dengue Early ELISA, Platelia NS1 and the NS1 Ag Strip was 34.7% (08/23), 60...
  17. Raven M, Lowe R, Maselli J, Hsia R. Comparison of presenting complaint vs discharge diagnosis for identifying " nonemergency" emergency department visits. JAMA. 2013;309:1145-53 pubmed publisher
    ..One consideration has been to deny payment if the patient's diagnosis upon ED discharge appears to reflect a "nonemergency" condition...
  18. Antinori S, Nebuloni M, Magni C, Fasan M, Adorni F, Viola A, et al. Trends in the postmortem diagnosis of opportunistic invasive fungal infections in patients with AIDS: a retrospective study of 1,630 autopsies performed between 1984 and 2002. Am J Clin Pathol. 2009;132:221-7 pubmed publisher
    ..Our results confirm the valuable role of autopsy data, even with highly effective therapies and advanced technologies. ..
  19. Pena G, Andrade Filho J. How does a pathologist make a diagnosis?. Arch Pathol Lab Med. 2009;133:124-32 pubmed publisher
    A pathologic diagnosis is the result of a complex series of activities, mastered by the pathologist. The nature of these activities is, however, rarely talked about in depth...
  20. Body R, Foex B. On the philosophy of diagnosis: is doing more good than harm better than "primum non nocere"?. Emerg Med J. 2009;26:238-40 pubmed publisher
    b>Diagnosis is arguably the cornerstone of medicine. Without at least some form of diagnosis the practice of medicine would not be possible...
  21. Golassa L, Abebe T, Hailu A. Evaluation of crude hydatid cyst fluid antigens for the serological diagnosis of hydatidosis in cattle. J Helminthol. 2011;85:100-8 pubmed publisher
    ..The purpose of this study was to evaluate the antigenic ability of hydatid cyst fluid antigen for the diagnosis of hydatidosis in cattle using enzyme-linked immunosorbent assay (ELISA) and indirect haemagglutination test (..
  22. You M, Zhao R, Li G, Hu X. MAPLSC: a novel multi-class classifier for medical diagnosis. Int J Data Min Bioinform. 2011;5:383-401 pubmed
    ..Elaborated comparisons with other seven state-of-the-art methods on two TCM clinical datasets and four public microarray datasets demonstrate MAPLSC's remarkable improvements. ..
  23. Brown P, Lyson M, Jenkins T. From diagnosis to social diagnosis. Soc Sci Med. 2011;73:939-43 pubmed publisher
    In the past two decades, research on the sociology of diagnosis has attained considerable influence within medical sociology...
  24. Gagliardi F. Instance-based classifiers applied to medical databases: diagnosis and knowledge extraction. Artif Intell Med. 2011;52:123-39 pubmed publisher
    ..We consider three clinical databases: one relating to the differential diagnosis of erythemato-squamous diseases, the second to the diagnosis of the onset of diabetes mellitus and the third ..
  25. Schutters K, Reutelingsperger C. Phosphatidylserine targeting for diagnosis and treatment of human diseases. Apoptosis. 2010;15:1072-82 pubmed publisher
    ..Recently focus has shifted from diagnostic towards therapeutic applications employing annexin A5 in strategies to deliver drugs to cells that express PS at their surface. ..
  26. John M, Lila A, Bandgar T, Menon P, Shah N. Diagnostic efficacy of midnight cortisol and midnight ACTH in the diagnosis and localisation of Cushing's syndrome. Pituitary. 2010;13:48-53 pubmed publisher
    Classical tests for diagnosis of Cushing's syndrome (CS) like urine free cortisol and dexamethasone suppression tests have limitations in various clinical settings...
  27. Zhang A, Sun H, Wang X. Saliva metabolomics opens door to biomarker discovery, disease diagnosis, and treatment. Appl Biochem Biotechnol. 2012;168:1718-27 pubmed publisher
    ..In particular, proof of principle has been demonstrated for salivary biomarker research...
  28. Klonisch T, Drouin R. Fetal-maternal exchange of multipotent stem/progenitor cells: microchimerism in diagnosis and disease. Trends Mol Med. 2009;15:510-8 pubmed publisher
    ..We discuss diagnostic challenges, clinical applications and future research directions in this exciting and rapidly emerging field of allogeneic fetal-maternal cell exchange. ..
  29. Chang H, Weiner J. An in-depth assessment of a diagnosis-based risk adjustment model based on national health insurance claims: the application of the Johns Hopkins Adjusted Clinical Group case-mix system in Taiwan. BMC Med. 2010;8:7 pubmed publisher
    b>Diagnosis-based risk adjustment is becoming an important issue globally as a result of its implications for payment, high-risk predictive modelling and provider performance assessment...
  30. Karenberg A. Retrospective diagnosis: use and abuse in medical historiography. Prague Med Rep. 2009;110:140-5 pubmed
    ..sometimes called pathographies, constitute the by far largest section of publications dealing with historical diagnosis. The procedure of attaching modern diagnostic labels to illustrious personalities of the past, i.e...
  31. Gouzouasis I, Karathanasis K, Karanasiou I, Uzunoglu N. Contactless passive diagnosis for brain intracranial applications: A study using dielectric matching materials. Bioelectromagnetics. 2010;31:335-49 pubmed publisher
  32. Chi C, Street W, Katz D. A decision support system for cost-effective diagnosis. Artif Intell Med. 2010;50:149-61 pubmed publisher
    Speed, cost, and accuracy are three important goals in disease diagnosis. This paper proposes a machine learning-based expert system algorithm to optimize these goals and assist diagnostic decisions in a sequential decision-making ..
  33. Maglogiannis I, Constantinos D, Kazatzopoulos L. Enabling collaborative medical diagnosis over the Internet via peer-to-peer distribution of electronic health records. J Med Syst. 2006;30:107-16 pubmed
    ..The system was considered by them to be very useful, as they found that the platform simulated very well the personal contact between them and their colleagues during medical meetings. ..
  34. Woods N, Brooks L, Norman G. The role of biomedical knowledge in diagnosis of difficult clinical cases. Adv Health Sci Educ Theory Pract. 2007;12:417-26 pubmed
    Although biomedical knowledge is believed to be of little value in diagnosis of routine clinical cases, studies of clinical reasoning have found that physicians revert to use of basic biomedical knowledge when faced with challenging ..
  35. Smidt N, Rutjes A, van der Windt D, Ostelo R, Reitsma J, Bossuyt P, et al. Quality of reporting of diagnostic accuracy studies. Radiology. 2005;235:347-53 pubmed
    ..Authors, editors, and reviewers should pay more attention to reporting by checking STARD statement items and including a flow diagram to represent study design and patient flow. ..
  36. Marcin J, Nesbitt T, Cole S, Knuttel R, Hilty D, Prescott P, et al. Changes in diagnosis, treatment, and clinical improvement among patients receiving telemedicine consultations. Telemed J E Health. 2005;11:36-43 pubmed
    ..outpatient telemedicine specialty consultations to primary care clinicians result in changes in a patient's diagnosis, treatment management, and clinical outcomes...
  37. Lowe J, Hand N, Mayer R. Application of ubiquitin immunohistochemistry to the diagnosis of disease. Methods Enzymol. 2005;399:86-119 pubmed
    ..The goal is to understand fully the role of the UPS in the disorders and then therapeutically intervene in the ubiquitin pathway to treat these incurable diseases. ..
  38. Bynum A, Cranford C, Irwin C, Banken J. Effect of telemedicine on patients' diagnosis and treatment. J Telemed Telecare. 2006;12:39-43 pubmed
    ..Changes in the patient's diagnosis and treatment plan as a result of the telemedicine session were assessed...
  39. Seising R. From vagueness in medical thought to the foundations of fuzzy reasoning in medical diagnosis. Artif Intell Med. 2006;38:237-56 pubmed
    This article delineates a relatively unknown path in the history of medical philosophy and medical diagnosis. It is concerned with the phenomenon of vagueness in the physician's "style of thinking" and with the use of fuzzy ..
  40. Zhang B, El Jawahri A, Prigerson H. Update on bereavement research: evidence-based guidelines for the diagnosis and treatment of complicated bereavement. J Palliat Med. 2006;9:1188-203 pubmed
  41. Henderson T, Shepheard J, Sundararajan V. Quality of diagnosis and procedure coding in ICD-10 administrative data. Med Care. 2006;44:1011-9 pubmed
    ..There was no difference in the median number of hospital assigned diagnosis and procedure codes per discharge...
  42. Arrizabalaga J. Problematizing retrospective diagnosis in the history of disease. Asclepio. 2002;54:51-70 pubmed
  43. Soltani A, Moayyeri A. Towards evidence-based diagnosis in developing countries: the use of likelihood ratios for robust quick diagnosis. Ann Saudi Med. 2006;26:211-5 pubmed
    ..EBM could be a significant aid to physicians in the developing world. ..
  44. Sundqvist N, Garrick T, Bishop I, Harper C. Reliability of post-mortem psychiatric diagnosis for neuroscience research. Aust N Z J Psychiatry. 2008;42:221-7 pubmed publisher
    The validity of post-mortem human brain research relies upon accurate clinical and psychopathological diagnosis. Current literature indicates few instances where standardized diagnostic assessment tools such as the Diagnostic Instrument ..
  45. Stivers T. Presenting the problem in pediatric encounters: "symptoms only" versus "candidate diagnosis" presentations. Health Commun. 2002;14:299-338 pubmed
    ..which offer "symptoms only" versus problem presentations, which also include a "candidate diagnosis." This article suggests that parents who offer only symptoms in their problem presentations are hearable as ..
  46. Marur S, Forastiere A. Head and neck cancer: changing epidemiology, diagnosis, and treatment. Mayo Clin Proc. 2008;83:489-501 pubmed publisher
  47. Zhan C, Elixhauser A, Friedman B, Houchens R, Chiang Y. Modifying DRG-PPS to include only diagnoses present on admission: financial implications and challenges. Med Care. 2007;45:288-91 pubmed
    ..and then on POA diagnoses in the Medicare discharge abstracts from California and New York in 2003, using the Diagnosis Related Group (DRG)-based Prospective Payment System (PPS) formula...
  48. Bachmann L, Coray R, Estermann P, Ter Riet G. Identifying diagnostic studies in MEDLINE: reducing the number needed to read. J Am Med Inform Assoc. 2002;9:653-8 pubmed
    ..Additional research is required to determine whether these improvements are beneficial to searches in practice. ..
  49. Hersh W, Hickam D, Severance S, Dana T, Pyle Krages K, Helfand M. Diagnosis, access and outcomes: Update of a systematic review of telemedicine services. J Telemed Telecare. 2006;12 Suppl 2:S3-31 pubmed
    ..We reviewed the literature for telemedicine services that substitute for face-to-face medical diagnosis and treatment...
  50. Roulson J, Benbow E, Hasleton P. Discrepancies between clinical and autopsy diagnosis and the value of post mortem histology; a meta-analysis and review. Histopathology. 2005;47:551-9 pubmed
    ..the autopsy and particularly autopsy histology are being undermined, they are still the most accurate method of determining the cause of death and auditing accuracy of clinical diagnosis, diagnostic tests and death certification.
  51. Pewsner D, Battaglia M, Minder C, Marx A, Bucher H, Egger M. Ruling a diagnosis in or out with "SpPIn" and "SnNOut": a note of caution. BMJ. 2004;329:209-13 pubmed
  52. Norman G, Eva K. Doggie diagnosis, diagnostic success and diagnostic reasoning strategies: an alternative view. Med Educ. 2003;37:676-7 pubmed
  53. McGinn T. Practice corner: using clinical prediction rules. ACP J Club. 2002;137:A11-2 pubmed