dapsone

Summary

Summary: A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)

Top Publications

  1. Werth V, Fivenson D, Pandya A, Chen D, Rico M, Albrecht J, et al. Multicenter randomized, double-blind, placebo-controlled, clinical trial of dapsone as a glucocorticoid-sparing agent in maintenance-phase pemphigus vulgaris. Arch Dermatol. 2008;144:25-32 pubmed publisher
    To determine the efficacy of dapsone as a glucocorticoid-sparing agent in maintenance-phase pemphigus vulgaris (PV). A randomized, double-blind, placebo-controlled study with a crossover arm for those who failed treatment...
  2. Fukae J, Noda K, Fujishima K, Wada R, Yoshiike T, Hattori N, et al. Successful treatment of relapsing neuro-Sweet's disease with corticosteroid and dapsone combination therapy. Clin Neurol Neurosurg. 2007;109:910-3 pubmed
    ..who presented with relapsing neuro-Sweet's disease that was successfully treated with a combination of corticosteroid and dapsone. Dapsone should be considered as a therapeutic option for neuro-Sweet's disease patients showing relapse.
  3. Smith L, Cox N. Dapsone treatment for eosinophilic fasciitis. Arch Dermatol. 2008;144:845-7 pubmed publisher
  4. Kast R, Lefranc F, Karpel Massler G, Halatsch M. Why dapsone stops seizures and may stop neutrophils' delivery of VEGF to glioblastoma. Br J Neurosurg. 2012;26:813-7 pubmed publisher
    ..recently published remarkable but mechanistically unexplained empirical evidence that the old antibiotic dapsone has antiepileptic activity...
  5. Shibata K, Tateishi T, Yamasaki R, Ohyagi Y, Kira J. [Successful treatment of a case of steroid-dependent neuro-Sweet disease with dapsone]. Rinsho Shinkeigaku. 2010;50:257-61 pubmed
    ..We started treatment with dapsone (75 mg/day) in addition to prednisolone, and could taper oral prednisolone, without a relapse...
  6. Kharfi M, Khaled A, Karaa A, Zaraa I, Fazaa B, Kamoun M. Linear IgA bullous dermatosis: the more frequent bullous dermatosis of children. Dermatol Online J. 2010;16:2 pubmed
    ..Indirect immunofluorescence was negative in 67 percent of cases. Eight patients responded to Dapsone, but prednisone had to be added in 7 children and erythromycin in 4 others to control the disease...
  7. Pamba A, Richardson N, Carter N, Duparc S, Premji Z, Tiono A, et al. Clinical spectrum and severity of hemolytic anemia in glucose 6-phosphate dehydrogenase-deficient children receiving dapsone. Blood. 2012;120:4123-33 pubmed publisher
    ..In 2 clinical trials of antimalarial preparations containing dapsone (4,4'-diaminodiphenylsulfone; 2...
  8. Broussard K, Berger T, Rosenblum M, Murase J. Erosive pustular dermatosis of the scalp: a review with a focus on dapsone therapy. J Am Acad Dermatol. 2012;66:680-6 pubmed publisher
    ..In the search for effective treatment for EPDS, we share our experience with topical dapsone 5% gel...
  9. Draelos Z, Carter E, Maloney J, Elewski B, Poulin Y, Lynde C, et al. Two randomized studies demonstrate the efficacy and safety of dapsone gel, 5% for the treatment of acne vulgaris. J Am Acad Dermatol. 2007;56:439.e1-10 pubmed
    A new aqueous gel formulation of dapsone has been developed that allows clinically-effective doses of dapsone to be administered topically with minimal systemic absorption...

More Information

Publications62

  1. Wootton D, Opara H, Biagini G, Kanjala M, Duparc S, Kirby P, et al. Open-label comparative clinical study of chlorproguanil-dapsone fixed dose combination (Lapdap) alone or with three different doses of artesunate for uncomplicated Plasmodium falciparum malaria. PLoS ONE. 2008;3:e1779 pubmed publisher
    ..to determine the appropriate dose of artesunate for use in a fixed dose combination therapy with chlorproguanil-dapsone (CPG-DDS) for the treatment of uncomplicated falciparum malaria...
  2. Pandey B, Shrestha K, Lewis J, Hawksworth R, Walker S. Mortality due to dapsone hypersensitivity syndrome complicating multi-drug therapy for leprosy in Nepal. Trop Doct. 2007;37:162-3 pubmed
    b>Dapsone is a component of multi-drug therapy (MDT) for the treatment of all types of leprosy. It is known that dapsone hypersensitivity syndrome (DHS) complicates the treatment in a proportion of patients...
  3. Zhang F, Liu H, Irwanto A, Fu X, Li Y, Yu G, et al. HLA-B*13:01 and the dapsone hypersensitivity syndrome. N Engl J Med. 2013;369:1620-8 pubmed publisher
    b>Dapsone is used in the treatment of infections and inflammatory diseases. The dapsone hypersensitivity syndrome, which is associated with a reported mortality of 9.9%, develops in about 0.5 to 3.6% of persons treated with the drug...
  4. Kar B. Dapsone-induced photosensitivity: a rare clinical presentation. Photodermatol Photoimmunol Photomed. 2008;24:270-1 pubmed publisher
    b>Dapsone is an efficient anti-inflammatory and antimycobacterial agent. It is one of the main constituents of multidrug therapy (MDT). It acts by interference with folate metabolism...
  5. Engin B, Ozdemir M. Prospective randomized non-blinded clinical trial on the use of dapsone plus antihistamine vs. antihistamine in patients with chronic idiopathic urticaria. J Eur Acad Dermatol Venereol. 2008;22:481-6 pubmed
    ..The purpose of this study was to evaluate the efficacy and safety of dapsone in CIU...
  6. Ashurst J, Wasson M, Hauger W, Fritz W. Pathophysiologic mechanisms, diagnosis, and management of dapsone-induced methemoglobinemia. J Am Osteopath Assoc. 2010;110:16-20 pubmed
    b>Dapsone is a leprostatic agent commonly prescribed for the treatment of patients with leprosy, malaria, and a variety of blistering skin diseases, including dermatitis herpetiformis...
  7. Grundmann S, Kiefer S, Luger T, Brehler R. Delayed pressure urticaria - dapsone heading for first-line therapy?. J Dtsch Dermatol Ges. 2011;9:908-12 pubmed publisher
    ..Complete relief of symptoms is difficult. We used dapsone as an early therapeutic alternative in the event of treatment failure and established a standardized therapeutic ..
  8. Zaja F, Marin L, Chiozzotto M, Puglisi S, Volpetti S, Fanin R. Dapsone salvage therapy for adult patients with immune thrombocytopenia relapsed or refractory to steroid and rituximab. Am J Hematol. 2012;87:321-3 pubmed publisher
    b>Dapsone is an antibacterial sulfonamide with anti-inflammatory property, which showed therapeutic activity in patients with immune thrombocytopenia (ITP); the activity in patients who showed refractoriness to rituximab is unknown...
  9. Premji Z, Umeh R, Owusu Agyei S, Esamai F, Ezedinachi E, Oguche S, et al. Chlorproguanil-dapsone-artesunate versus artemether-lumefantrine: a randomized, double-blind phase III trial in African children and adolescents with uncomplicated Plasmodium falciparum malaria. PLoS ONE. 2009;4:e6682 pubmed publisher
    Chlorproguanil-dapsone-artesunate (CDA) was developed as an affordable, simple, fixed-dose artemisinin-based combination therapy for use in Africa...
  10. Zhou J, Cai S, Zheng M. Dapsone-induced infectious mononucleosis-like syndrome in a patient with pemphigus vulgaris. Chin Med J (Engl). 2007;120:1111-3 pubmed
  11. Varghese L, Viswabandya A, Mathew A. Dapsone, danazol, and intrapartum splenectomy in refractory ITP complicating pregnancy. Indian J Med Sci. 2008;62:452-5 pubmed
    ..Our patient with chronic ITP complicating pregnancy, who was refractory to steroids, dapsone, and danazol, was treated successfully with intrapartum splenectomy.
  12. Kanoh S, Tanabe T, Rubin B. Dapsone inhibits IL-8 secretion from human bronchial epithelial cells stimulated with lipopolysaccharide and resolves airway inflammation in the ferret. Chest. 2011;140:980-990 pubmed publisher
    ..b>Dapsone, a synthetic sulfone, is widely used to treat chronic neutrophil dermatoses...
  13. Walker J, Kadia T, Brown L, Juneja H, de Groot J. Dapsone induced methemoglobinemia in a patient with glioblastoma. J Neurooncol. 2009;94:149-52 pubmed publisher
    ..tumor patients have multiple risk factors for Pneumocystis jiroveci and may require prophylaxis with TMP-SMZ or dapsone. Although dapsone is generally safe and efficacious, we present a case of a patient diagnosed with a brain stem ..
  14. Dunyo S, Sirugo G, Sesay S, Bisseye C, Njie F, Adiamoh M, et al. Randomized trial of safety and effectiveness of chlorproguanil-dapsone and lumefantrine-artemether for uncomplicated malaria in children in the Gambia. PLoS ONE. 2011;6:e17371 pubmed publisher
    Chlorproguanil-dapsone (Lapdap), developed as a low-cost antimalarial, was withdrawn in 2008 after concerns about safety in G6PD deficient patients...
  15. Yazdanyar S, Boer J, Ingvarsson G, Szepietowski J, Jemec G. Dapsone therapy for hidradenitis suppurativa: a series of 24 patients. Dermatology. 2011;222:342-6 pubmed publisher
    ..The use of dapsone in the treatment of HS is based on a few published cases successfully treated...
  16. Naik P, Lyon G, Ramirez A, Lawrence E, Neujahr D, Force S, et al. Dapsone-induced hemolytic anemia in lung allograft recipients. J Heart Lung Transplant. 2008;27:1198-202 pubmed publisher
    Lung transplant (LT) recipients often receive dapsone for Pneumocystis jirovecii pneumonia (PCP) prophylaxis. However, the prevalence of dapsone-induced hematologic toxicity in LT recipients is unknown...
  17. Mutabingwa T, Muze K, Ord R, Briceño M, Greenwood B, Drakeley C, et al. Randomized trial of artesunate+amodiaquine, sulfadoxine-pyrimethamine+amodiaquine, chlorproguanal-dapsone and SP for malaria in pregnancy in Tanzania. PLoS ONE. 2009;4:e5138 pubmed publisher
    ..proven, falciparum malaria were randomised to one of 4 regimes: sulfadoxine-pyrimethamine [SP]; chlorproguanil-dapsone [CD]; SP+amodiaquine [SP+AQ] or amodiaquine+artesunate [AQ+AS]. Randomisation was on a 1ratio2ratio2ratio2 ratio...
  18. Leslie T, Mayan M, Hasan M, Safi M, Klinkenberg E, Whitty C, et al. Sulfadoxine-pyrimethamine, chlorproguanil-dapsone, or chloroquine for the treatment of Plasmodium vivax malaria in Afghanistan and Pakistan: a randomized controlled trial. JAMA. 2007;297:2201-9 pubmed
    ..The antifolates are an important and affordable antimalarial class to which it is often assumed P vivax malaria is intrinsically resistant...
  19. Raimer S, Maloney J, Bourcier M, Wilson D, Papp K, Siegfried E, et al. Efficacy and safety of dapsone gel 5% for the treatment of acne vulgaris in adolescents. Cutis. 2008;81:171-8 pubmed
    ..long-term, open-label, noncomparative safety study were conducted to evaluate the efficacy and safety of dapsone gel 5% in patients with acne vulgaris...
  20. Monteiro L, Lione V, do Carmo F, do Amaral L, da Silva J, Nasciutti L, et al. Development and characterization of a new oral dapsone nanoemulsion system: permeability and in silico bioavailability studies. Int J Nanomedicine. 2012;7:5175-82 pubmed publisher
    b>Dapsone is described as being active against Mycobacterium leprae, hence its role in the treatment of leprosy and related pathologies...
  21. Wozel V. Innovative use of dapsone. Dermatol Clin. 2010;28:599-610 pubmed publisher
    After synthesis of dapsone (4,4' diaminodiphenylsulfone) in 1908, the compound was known exclusively in chemistry...
  22. Fanello C, Karema C, Avellino P, Bancone G, Uwimana A, Lee S, et al. High risk of severe anaemia after chlorproguanil-dapsone+artesunate antimalarial treatment in patients with G6PD (A-) deficiency. PLoS ONE. 2008;3:e4031 pubmed publisher
    ..The safety of chlorproguanil-dapsone+artesunate (CD+A) and amodiaquine+sulphadoxine-pyrimethamine (AQ+SP) for the treatment of uncomplicated P...
  23. Esbenshade A, Ho R, Shintani A, Zhao Z, Smith L, Friedman D. Dapsone-induced methemoglobinemia: a dose-related occurrence?. Cancer. 2011;117:3485-92 pubmed publisher
    b>Dapsone, used for Pneumocystis jiroveci (PCP) prophylaxis, is associated with increased risk of methemoglobinemia...
  24. Ganesan S, Sahu R, Walker L, Tekwani B. Cytochrome P450-dependent toxicity of dapsone in human erythrocytes. J Appl Toxicol. 2010;30:271-5 pubmed publisher
    The most prominent adverse effects seen during treatment with dapsone, an antibacterial and antiprotozoal agent, are hemolysis and methemoglobinemia...
  25. Fanello C, Karema C, Ngamije D, Uwimana A, Ndahindwa V, Van Overmeir C, et al. A randomised trial to assess the efficacy and safety of chlorproguanil/dapsone + artesunate for the treatment of uncomplicated Plasmodium falciparum malaria. Trans R Soc Trop Med Hyg. 2008;102:412-20 pubmed publisher
    We tested the efficacy and safety of chlorproguanil/dapsone co-administered with artesunate (CD+A) for the treatment of uncomplicated Plasmodium falciparum malaria in children compared with amodiaquine+sulfadoxine/pyrimethamine (AQ+SP) ..
  26. Van Malderen C, Van Geertruyden J, Machevo S, Gonzalez R, Bassat Q, Talisuna A, et al. Glucose-6-phosphate dehydrogenase deficiency, chlorproguanil-dapsone with artesunate and post-treatment haemolysis in African children treated for uncomplicated malaria. Malar J. 2012;11:139 pubmed publisher
    ..Chlorproguanil-dapsone-artesunate (CDA) was a promising artemisinin-based combination therapy (ACT), but its development was prematurely ..
  27. Bordin L, Fiore C, Zen F, Coleman M, Ragazzi E, Clari G. Dapsone hydroxylamine induces premature removal of human erythrocytes by membrane reorganization and antibody binding. Br J Pharmacol. 2010;161:1186-99 pubmed publisher
    N-hydroxylation of dapsone leads to the formation of the toxic hydroxylamines responsible for the clinical methaemoglobinaemia associated with dapsone therapy...
  28. Vieira J, Riveira J, Martins A, Silva J, Salgado C. Methemoglobinemia and dapsone levels in patients with leprosy. Braz J Infect Dis. 2010;14:319-21 pubmed
    The objective of this work was to determine the methemoglobinemia and correlate with dapsone levels in multibacillary leprosy patients under leprosy multi-drug therapy...
  29. Bardsley B, Barry S, Drozdz M, Hancock S, Okafo G, Szafran M. Formation and identification of a degradant in chlorproguanil-dapsone-artesunate (Dacart™) tablets. J Pharm Biomed Anal. 2011;54:610-3 pubmed publisher
    Chlorproguanil hydrochloride, dapsone and artesunate are three compounds with anti-malarial properties developed as a triple combination drug product (Dacart™) for the treatment of malarial infections...
  30. Tiono A, Dicko A, Ndububa D, Agbenyega T, Pitmang S, Awobusuyi J, et al. Chlorproguanil-dapsone-artesunate versus chlorproguanil-dapsone: a randomized, double-blind, phase III trial in African children, adolescents, and adults with uncomplicated Plasmodium falciparum malaria. Am J Trop Med Hyg. 2009;81:969-78 pubmed publisher
    ..randomized, parallel-group, double-blind, double-dummy study compared the efficacy and safety of chlorproguanil-dapsone-artesunate (CDA) and chlorproguanil-dapsone (CPG-DDS) in the treatment of falciparum malaria in Africa (Burkina ..
  31. Kast R, Scheuerle A, Wirtz C, Karpel Massler G, Halatsch M. The rationale of targeting neutrophils with dapsone during glioblastoma treatment. Anticancer Agents Med Chem. 2011;11:756-61 pubmed
    ..Since the old anti-Hansen's disease drug dapsone inhibits neutrophil migration along an IL-8 gradient towards increasing concentrations, and is used ..
  32. Sheen Y, Chu C, Wang S, Tsai T. Dapsone hypersensitivity syndrome in non-leprosy patients: a retrospective study of its incidence in a tertiary referral center in Taiwan. J Dermatolog Treat. 2009;20:340-3 pubmed publisher
    b>Dapsone hypersensitivity syndrome (DHS) is a potentially life-threatening adverse drug reaction consisting of fever, hepatitis, exfoliative dermatitis, lymphadenopathy and hemolytic anemia...
  33. Owusu Agyei S, Asante K, Owusu R, Adjuik M, Amenga Etego S, Dosoo D, et al. An open label, randomised trial of artesunate+amodiaquine, artesunate+chlorproguanil-dapsone and artemether-lumefantrine for the treatment of uncomplicated malaria. PLoS ONE. 2008;3:e2530 pubmed publisher
    ..Artesunate+chlorproguanil-dapsone (AS+CD) was a potential alternative for treatment of uncomplicated malaria...
  34. Piette E, Werth V. Dapsone in the management of autoimmune bullous diseases. Dermatol Clin. 2011;29:561-4 pubmed publisher
    b>Dapsone is used in the treatment of autoimmune bullous diseases (AIBD), a group of disorders resulting from autoimmunity directed against basement membrane and/or intercellular adhesion molecules on cutaneous and mucosal surfaces...
  35. Gosling R, Gesase S, Mosha J, Carneiro I, Hashim R, Lemnge M, et al. Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial. Lancet. 2009;374:1521-32 pubmed publisher
    ..5 mg; n=319 in moderate-transmission and 283 in low-transmission sites), chlorproguanil (15 mg) plus dapsone (18...
  36. Gürcan H, Ahmed A. Efficacy of dapsone in the treatment of pemphigus and pemphigoid: analysis of current data. Am J Clin Dermatol. 2009;10:383-96 pubmed publisher
    b>Dapsone is a chemotherapeutic agent primarily used in treating leprosy, Pneumocystis jiroveci (previously carinii) pneumonia, and malaria. It is also used as an adjuvant in the treatment of pemphigus and pemphigoid...
  37. Lorenz M, Wozel G, Schmitt J. Hypersensitivity reactions to dapsone: a systematic review. Acta Derm Venereol. 2012;92:194-9 pubmed publisher
    b>Dapsone is widely used in the treatment of leprosy and several chronic inflammatory dermatological conditions. Hypersensitivity reactions to dapsone are potentially fatal adverse drug reactions with unknown prevalence and risk factors...
  38. Deps P, Guerra P, Nasser S, Simon M. Hemolytic anemia in patients receiving daily dapsone for the treatment of leprosy. Lepr Rev. 2012;83:305-7 pubmed
    Multidrug therapy for leprosy is currently done with dapsone, clofazimine and rifampicin. Dapsone is known to cause hemolytic anemia (HA) and this adverse event during MDT seems to be more frequent than reported...
  39. Gupta U, Katoch K, Katoch V. Study of rifampicin resistance and comparison of dapsone resistance of M. leprae in pre- and post-MDT era. Indian J Lepr. 2009;81:131-4 pubmed
    The aim of this study to study the drug resistance patterns of dapsone (pre- and post-MDT) and rifampicin (post-MDT era)...
  40. Malfará W, Pereira C, Santos A, Queiroz R. Effects of H(2)-receptor antagonists on dapsone-induced methaemoglobinaemia in rats. Pharmacol Res. 2002;45:269-73 pubmed
    b>Dapsone (DDS) (4,4'diaminodiphenylsulfone), the drug of choice for the treatment of leprosy, frequently induces haemolytic anaemia and methaemoglobinaemia...
  41. Talarico J, Metro D. Presentation of dapsone-induced methemoglobinemia in a patient status post small bowel transplant. J Clin Anesth. 2005;17:568-70 pubmed
    ..b>Dapsone, a sulfone antibiotic, is used for prophylaxis against Pneumocystis carinii pneumonia in immunosuppressed ..
  42. Hughes A, Callen J. Epidermolysis bullosa acquisita responsive to dapsone therapy. J Cutan Med Surg. 2001;5:397-9 pubmed
    ..Complete control of his blistering was achieved within two months of initiating oral dapsone, 150 mg per day. Dapsone may be an effective agent for some patients with EBA.
  43. Kublin J, Dzinjalamala F, Kamwendo D, Malkin E, Cortese J, Martino L, et al. Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria. J Infect Dis. 2002;185:380-8 pubmed
    ..treatment outcomes in a double-blind, placebo-controlled trial of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment for uncomplicated P. falciparum malaria...
  44. Albright E, Ovalle F, Bell D. Artificially low hemoglobin A1c caused by use of dapsone. Endocr Pract. 2002;8:370-2 pubmed
    To describe a case of artifactually decreased hemoglobin Alc (HbAlc) attributable to use of dapsone. We present a detailed case report and results of a related literature search...
  45. Kazanjian P, Armstrong W, Hossler P, Burman W, Richardson J, Lee C, et al. Pneumocystis carinii mutations are associated with duration of sulfa or sulfone prophylaxis exposure in AIDS patients. J Infect Dis. 2000;182:551-7 pubmed
    ..1; P=0.01). Thus, an increased duration of sulfa or sulfone prophylaxis increases the chance of developing a P. carinii mutation. The majority of patients with mutations respond to sulfa or sulfone therapy. ..
  46. Alloueche A, Bailey W, Barton S, Bwika J, Chimpeni P, Falade C, et al. Comparison of chlorproguanil-dapsone with sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in young African children: double-blind randomised controlled trial. Lancet. 2004;363:1843-8 pubmed
    ..We aimed to assess the safety profile of chlorproguanil-dapsone (CD), and to compare the safety and efficacy of this drug with that of sulfadoxine-pyrimethamine (SP) as ..
  47. Mutabingwa T, Nzila A, Mberu E, Nduati E, Winstanley P, Hills E, et al. Chlorproguanil-dapsone for treatment of drug-resistant falciparum malaria in Tanzania. Lancet. 2001;358:1218-23 pubmed
    ..We did an open, alternate drug allocation study to assess the efficacy of chlorproguanil-dapsone in the treatment of falciparum malaria clinically resistant to pyrimethamine-sulfadoxine...
  48. Winstanley P. Chlorproguanil-dapsone (LAPDAP) for uncomplicated falciparum malaria. Trop Med Int Health. 2001;6:952-4 pubmed
    The synergistic antifolate combination of chlorproguanil with dapsone (CPG-DDS; LAPDAP) is being developed by a public-private partnership as a low-cost treatment for uncomplicated falciparum malaria...
  49. Itha S, Kumar A, Dhingra S, Choudhuri G. Dapsone induced cholangitis as a part of dapsone syndrome: a case report. BMC Gastroenterol. 2003;3:21 pubmed
    b>Dapsone can rarely cause a hypersensitivity reaction called dapsone syndrome, consisting of fever, hepatitis, exfoliative dermatitis, lymphadenopathy and hemolytic anemia...
  50. Paniker U, Levine N. Dapsone and sulfapyridine. Dermatol Clin. 2001;19:79-86, viii pubmed
    b>Dapsone and sulfapyridine are structurally related compounds with anti-microbial and anti-inflammatory effects...
  51. Prussick R, Ali M, Rosenthal D, Guyatt G. The protective effect of vitamin E on the hemolysis associated with dapsone treatment in patients with dermatitis herpetiformis. Arch Dermatol. 1992;128:210-3 pubmed
    This study looked at whether oral vitamin C and vitamin E would protect the erythrocyte from oxidant damage caused by dapsone in patients with dermatitis herpetiformis.
  52. ALLDAY E, Barnes J. Toxic effects of diaminodiphenylsulphone in treatment of leprosy. Lancet. 1951;2:205-6 pubmed
  53. Winstanley P, Watkins W, Muhia D, Szwandt S, Amukoye E, Marsh K. Chlorproguanil/dapsone for uncomplicated Plasmodium falciparum malaria in young children: pharmacokinetics and therapeutic range. Trans R Soc Trop Med Hyg. 1997;91:322-7 pubmed
    The disposition of chlorproguanil/dapsone (one daily dose for 3 d of 1.2 and 2...