blood volume


Summary: Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME.

Top Publications

  1. Deipolyi A, Wu O, Macklin E, Schaefer P, Schwamm L, Gilberto González R, et al. Reliability of cerebral blood volume maps as a substitute for diffusion-weighted imaging in acute ischemic stroke. J Magn Reson Imaging. 2012;36:1083-7 pubmed publisher
    To assess the reliability of cerebral blood volume (CBV) maps as a substitute for diffusion-weighted MRI (DWI) in acute ischemic stroke. In acute stroke, DWI is often used to identify irreversibly injured "core" tissue...
  2. Lacalle Aurioles M, Mateos Pérez J, Guzmán De Villoria J, Olazarán J, Cruz Orduña I, Aleman Gomez Y, et al. Cerebral blood flow is an earlier indicator of perfusion abnormalities than cerebral blood volume in Alzheimer's disease. J Cereb Blood Flow Metab. 2014;34:654-9 pubmed publisher
    ..can better characterize perfusion abnormalities in predementia stages of Alzheimer's disease (AD) than cerebral blood volume (CBV) and whether cortical atrophy is more associated with decreased CBV or with decreased CBF...
  3. Kanski M, Arheden H, Wuttge D, Bozovic G, Hesselstrand R, Ugander M. Pulmonary blood volume indexed to lung volume is reduced in newly diagnosed systemic sclerosis compared to normals--a prospective clinical cardiovascular magnetic resonance study addressing pulmonary vascular changes. J Cardiovasc Magn Reson. 2013;15:86 pubmed publisher
    ..9 men, 57 ± 13 years) and 10 healthy controls (3 men, 54 ± 9 years) underwent CMR to determine the pulmonary blood volume (PBV) and the PBV variation (PBVV) throughout the cardiac cycle...
  4. Miao X, Gu H, Yan L, Lu H, Wang D, Zhou X, et al. Detecting resting-state brain activity by spontaneous cerebral blood volume fluctuations using whole brain vascular space occupancy imaging. Neuroimage. 2014;84:575-84 pubmed publisher
    ..Our study suggests that 3D-GRASE VASO imaging, with its improved spatial specificity and less sensitivity to susceptibility artifacts, may have advantages in resting-state fMRI studies. ..
  5. Jung S, Choi S, Yeom J, Kim J, Ryoo I, Kim S, et al. Cerebral blood volume analysis in glioblastomas using dynamic susceptibility contrast-enhanced perfusion MRI: a comparison of manual and semiautomatic segmentation methods. PLoS ONE. 2013;8:e69323 pubmed publisher
    ..reproducibilities of manual and semiautomatic segmentation method for the measurement of normalized cerebral blood volume (nCBV) using dynamic susceptibility contrast-enhanced (DSC) perfusion MR imaging in glioblastomas...
  6. Kim H, Choi S, Kim J, Ryoo I, Kim S, Yeom J, et al. Gliomas: application of cumulative histogram analysis of normalized cerebral blood volume on 3 T MRI to tumor grading. PLoS ONE. 2013;8:e63462 pubmed publisher
    ..The objective of our study was to retrospectively assess the usefulness of a cumulative normalized cerebral blood volume (nCBV) histogram for glioma grading based on 3 T MRI...
  7. Martinot J, Mule M, de Bisschop C, Overbeek M, Le Dong N, Naeije R, et al. Lung membrane conductance and capillary volume derived from the NO and CO transfer in high-altitude newcomers. J Appl Physiol (1985). 2013;115:157-66 pubmed publisher
    ..After exercise, DmCO decreased slightly less in subjects treated by the vasodilators, suggesting a beneficial effect on interstitial edema. ..
  8. Jain R, Narang J, Griffith B, Bagher Ebadian H, Scarpace L, Mikkelsen T, et al. Prognostic vascular imaging biomarkers in high-grade gliomas: tumor permeability as an adjunct to blood volume estimates. Acad Radiol. 2013;20:478-85 pubmed publisher
    ..The purpose of our retrospective study was to correlate patient survival with relative cerebral blood volume (rCBV) and permeability surface area-product (PS) measured using perfusion computed tomography (PCT) in ..
  9. Bulte C, Slikkerveer J, Kamp O, Heymans M, Loer S, de Marchi S, et al. General anesthesia with sevoflurane decreases myocardial blood volume and hyperemic blood flow in healthy humans. Anesth Analg. 2013;116:767-74 pubmed publisher
    ..MBF was calculated from the relative myocardial blood volume multiplied by its exchange frequency (?) divided by myocardial tissue density (?T), which was set at 1...

More Information


  1. Lu H, Hua J, van Zijl P. Noninvasive functional imaging of cerebral blood volume with vascular-space-occupancy (VASO) MRI. NMR Biomed. 2013;26:932-48 pubmed publisher
    Functional MRI (fMRI) based on changes in cerebral blood volume (CBV) can probe directly vasodilatation and vasoconstriction during brain activation or physiologic challenges, and can provide important insights into the mechanism of blood ..
  2. Wang J, Xiao J, Wei X, Wang L, Lin L, Liu Z, et al. Circulating endothelial cells and tumor blood volume as predictors in lung cancer. Cancer Sci. 2013;104:445-52 pubmed publisher
    ..Tumor blood volume (BV) in computed tomography perfusion imaging and circulating endothelial cells (CEC) might predict the status ..
  3. Lin C, Yu M, Hung S, Teng M, Guo W, Chang F, et al. In-room assessment of cerebral blood volume for guidance during intra-arterial thrombolytic therapy. Interv Neuroradiol. 2012;18:463-8 pubmed
    ..Flat-panel post-contrast DynaCT imaging can provide both vasculature and parenchymal blood volume within the angio room to monitor hemodynamic changes during the endovascular procedures...
  4. Friedman S, Bambrough P, Kotsarini C, Khandanpour N, Hoggard N. Semi-automated and automated glioma grading using dynamic susceptibility-weighted contrast-enhanced perfusion MRI relative cerebral blood volume measurements. Br J Radiol. 2012;85:e1204-11 pubmed publisher
    ..Relative cerebral blood volume (rCBV) is a dynamic susceptibility-weighted contrast-enhanced perfusion MRI parameter that has been shown to ..
  5. Benders M, Hendrikse J, de Vries L, Groenendaal F, van Bel F. Doppler-assessed cerebral blood flow velocity in the neonate as estimator of global cerebral blood volume flow measured using phase-contrast magnetic resonance angiography. Neonatology. 2013;103:21-6 pubmed publisher
    ..determined as soon as possible after determination of phase-contrast magnetic resonance angiography-measured blood volume flow (PC-MRA BVF) by adding up angle-corrected time-averaged mean flow velocities of both internal carotid ..
  6. Bekar L, Wei H, Nedergaard M. The locus coeruleus-norepinephrine network optimizes coupling of cerebral blood volume with oxygen demand. J Cereb Blood Flow Metab. 2012;32:2135-45 pubmed publisher
    ..and temporal focusing of the hyperemic response resulting in a sixfold decrease in the disparity between blood volume and oxygen demand...
  7. Baek H, Kim H, Kim N, Choi Y, Kim Y. Percent change of perfusion skewness and kurtosis: a potential imaging biomarker for early treatment response in patients with newly diagnosed glioblastomas. Radiology. 2012;264:834-43 pubmed publisher
    To test the predictive value of skewness and kurtosis changes of normalized cerebral blood volume (nCBV) during the early treatment period for differentiating early tumor progression from pseudoprogression in patients with newly diagnosed ..
  8. Lalande S, Yerly P, Faoro V, Naeije R. Pulmonary vascular distensibility predicts aerobic capacity in healthy individuals. J Physiol. 2012;590:4279-88 pubmed publisher
    ..V(O(2)max) could also exhibit a higher pulmonary vascular distensibility and increased pulmonary capillary blood volume during exercise...
  9. Hecking M, Antlanger M, Winnicki W, Reiter T, Werzowa J, Haidinger M, et al. Blood volume-monitored regulation of ultrafiltration in fluid-overloaded hemodialysis patients: study protocol for a randomized controlled trial. Trials. 2012;13:79 pubmed publisher
    ..Here, we aim at testing the hypothesis that, in comparison to conventional hemodialysis, blood volume-monitored regulation of ultrafiltration and dialysate conductivity (UCR) and/or regulation of ultrafiltration ..
  10. Kalantar Zadeh K, Regidor D, Kovesdy C, Van Wyck D, Bunnapradist S, Horwich T, et al. Fluid retention is associated with cardiovascular mortality in patients undergoing long-term hemodialysis. Circulation. 2009;119:671-9 pubmed publisher
    ..The mechanisms by which fluid retention influences cardiovascular survival in hemodialysis may be similar to those in patients with heart failure and warrant further research. ..
  11. Lindenberger M, Länne T. Reduced defense of central blood volume during acute lower body negative pressure-induced hypovolemic circulatory stress in aging women. Shock. 2012;37:579-85 pubmed publisher
    ..vulnerable to trauma and hemorrhage than young and elderly men and respond with decreased defense of central blood volume during acute experimental hypovolemia induced by lower body negative pressure (LBNP)...
  12. Mutoh T, Kazumata K, Kobayashi S, Terasaka S, Ishikawa T. Serial measurement of extravascular lung water and blood volume during the course of neurogenic pulmonary edema after subarachnoid hemorrhage: initial experience with 3 cases. J Neurosurg Anesthesiol. 2012;24:203-8 pubmed publisher
    ..This is the first report to demonstrate the ability of a bedside transpulmonary thermodilution device to trace physiological patterns consistent with current theories regarding the mechanism and course of post-SAH NPE...
  13. Thomsen H, Steffensen E, Larsson E. Perfusion MRI (dynamic susceptibility contrast imaging) with different measurement approaches for the evaluation of blood flow and blood volume in human gliomas. Acta Radiol. 2012;53:95-101 pubmed publisher
    ..Relative cerebral blood volume (rCBV) is usually obtained by dynamic susceptibility contrast (DSC) MRI using normal appearing white matter as ..
  14. Sillanpää N, Saarinen J, Rusanen H, Hakomäki J, Lahteela A, Numminen H, et al. The clot burden score, the Boston Acute Stroke Imaging Scale, the cerebral blood volume ASPECTS, and two novel imaging parameters in the prediction of clinical outcome of ischemic stroke patients receiving intravenous thrombolytic therapy. Neuroradiology. 2012;54:663-72 pubmed publisher
    ..Binary logistic regression model was used to assess how BASIS, CBS, and cerebral blood volume (CBV) ASPECTS predict favorable clinical outcome...
  15. Keunen O, Johansson M, Oudin A, Sanzey M, Rahim S, Fack F, et al. Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma. Proc Natl Acad Sci U S A. 2011;108:3749-54 pubmed publisher
    ..The present work underlines the need to combine anti-angiogenic treatment in GBMs with drugs targeting specific signaling or metabolic pathways linked to the glycolytic phenotype. ..
  16. Qin H, Sun H, Li Y, Shen B. Application of CT perfusion imaging to the histological differentiation of adrenal gland tumors. Eur J Radiol. 2012;81:502-7 pubmed publisher
    ..CT perfusion imaging has been used in diagnosis and classification of tumors widely and in assess tumor angiogenesis in some organs. However, there are few reports describing CT perfusion imaging of adrenal gland tumors...
  17. Jain R, Gutierrez J, Narang J, Scarpace L, Schultz L, Lemke N, et al. In vivo correlation of tumor blood volume and permeability with histologic and molecular angiogenic markers in gliomas. AJNR Am J Neuroradiol. 2011;32:388-94 pubmed publisher
  18. Booth J, Pinney J, Davenport A. Do changes in relative blood volume monitoring correlate to hemodialysis-associated hypotension?. Nephron Clin Pract. 2011;117:c179-83 pubmed publisher
    Intradialytic hypotension remains the most common complication for outpatient hemodialysis, and relative blood volume monitoring was designed to reduce hypotension. Reports of the usefulness of this technology, however, have been variable...
  19. Li X, Rooney W, Varallyay C, Gahramanov S, Muldoon L, Goodman J, et al. Dynamic-contrast-enhanced-MRI with extravasating contrast reagent: rat cerebral glioma blood volume determination. J Magn Reson. 2010;206:190-9 pubmed publisher
    The accurate mapping of the tumor blood volume (TBV) fraction (vb) is a highly desired imaging biometric goal...
  20. Grant P, Roche Labarbe N, Surova A, Themelis G, Selb J, Warren E, et al. Increased cerebral blood volume and oxygen consumption in neonatal brain injury. J Cereb Blood Flow Metab. 2009;29:1704-13 pubmed publisher
    ..We aimed to determine whether cerebral tissue oxygenation (StO(2)), cerebral blood volume (CBV), and estimates of relative cerebral oxygen consumption (rCMRO(2)) determined by bedside frequency-domain ..
  21. Gabrielli D, Krystal B, Katzarski K, Youssef M, Hachache T, Lopot F, et al. Improved intradialytic stability during haemodialysis with blood volume-controlled ultrafiltration. J Nephrol. 2009;22:232-40 pubmed
    ..b>Blood volume monitoring and automatic feedback control of the UF rate were developed to limit the extent of hypovolaemia ..
  22. Nagamitsu S, Yamashita F, Araki Y, Iizuka C, Ozono S, Komatsu H, et al. Characteristic prefrontal blood volume patterns when imaging body type, high-calorie food, and mother-child attachment in childhood anorexia nervosa: A near infrared spectroscopy study. Brain Dev. 2010;32:162-7 pubmed publisher
    ..The prefrontal activations during each task, in terms of blood volume changes, were measured by near infrared spectroscopy. Twelve females with childhood AN (mean age, 14...
  23. Griffeth V, Buxton R. A theoretical framework for estimating cerebral oxygen metabolism changes using the calibrated-BOLD method: modeling the effects of blood volume distribution, hematocrit, oxygen extraction fraction, and tissue signal properties on the BOLD signal. Neuroimage. 2011;58:198-212 pubmed publisher
    ..However, other factors such as the cerebral blood volume (CBV) distribution at rest and with activation also affect the BOLD signal...