Summary: Long-term changes in the electrophysiological parameters and/or anatomical structures of the HEART ATRIA that result from prolonged changes in atrial rate, often associated with ATRIAL FIBRILLATION or long periods of intense EXERCISE.
Appelbaum E, Manning W. Left atrial fibrosis by late gadolinium enhancement cardiovascular magnetic resonance predicts recurrence of atrial fibrillation after pulmonary vein isolation: do you see what I see?. Circ Arrhythm Electrophysiol. 2014;7:2-4 pubmed publisher
Ziolo M, Mohler P. Defining the role of oxidative stress in atrial fibrillation and diabetes. J Cardiovasc Electrophysiol. 2015;26:223-5 pubmed publisher
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Qin M, Li L, Liu X, Liu T, Shi S. Neural substrate of posterior left atrium: A novel modulation for inducibility and remodeling of atrial fibrillation in canine. PLoS ONE. 2017;12:e0176626 pubmed publisher
..We sought to assess the contribution of PLA denervation on atrial fibrillation (AF) inducibility and atrial remodeling. After left thoracotomy in anesthetized dogs (n = 32), electrode catheters were attached to the PLA, left ..
Fernandes Cardoso A, Santos Furtado M, Grindler J, Ferreira L, Andrade J, Santo M. Epicardial fat thickness correlates with P-wave duration, left atrial size and decreased left ventricular systolic function in morbid obesity. Nutr Metab Cardiovasc Dis. 2017;27:731-738 pubmed publisher
..The influence of EF on atrial remodeling and cardiac function demands further investigation on morbidly obese without these comorbidities...
Kim C, Pokutta Paskaleva A, Kumar S, Timmins L, Morris A, Kang D, et al
. Disturbed Flow Promotes Arterial Stiffening Through Thrombospondin-1. Circulation. 2017;136:1217-1232 pubmed publisher
..Molecular targets in this pathway may lead to novel therapies to limit arterial stiffening and the progression of disease in arteries exposed to d-flow. ..
Lala R, Puschita M, Darabantiu D, Pilat L. Galectin-3 in heart failure pathology--"another brick in the wall"?. Acta Cardiol. 2015;70:323-31 pubmed
..whether the available data on galectin-3 are consistent enough to reduce readmissions and mortality while improving diagnosis and future therapies for heart failure, versus the possibility that it is simply"another brick in the wall?" ..
Veeraveedu P, Sanada S, Okuda K, Fu H, Matsuzaki T, Araki R, et al
. Ablation of IL-33 gene exacerbate myocardial remodeling in mice with heart failure induced by mechanical stress. Biochem Pharmacol. 2017;138:73-80 pubmed publisher
..These data highlight the cardioprotective role of IL-33/ST2 system in the stressed myocardium and reveal a potential therapeutic role for IL-33 in non-ischemic HF. ..
Brocklehurst P, Ni H, Zhang H, Ye J. Electro-mechanical dynamics of spiral waves in a discrete 2D model of human atrial tissue. PLoS ONE. 2017;12:e0176607 pubmed publisher