Summary: An anti-inflammatory 9-fluoro-glucocorticoid.

Top Publications

  1. ncbi Resetting of circadian time in peripheral tissues by glucocorticoid signaling
    A Balsalobre
    , Sciences II, , 30 Quai Ernest Ansermet, , Switzerland
    Science 289:2344-7. 2000
  2. pmc Genomic determination of the glucocorticoid response reveals unexpected mechanisms of gene regulation
    Timothy E Reddy
    HudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA
    Genome Res 19:2163-71. 2009
  3. pmc TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice
    Laura McKinley
    Department of Pediatrics, Lung Immunology and Host Defense Laboratory, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Immunol 181:4089-97. 2008
  4. ncbi Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro
    N Jaiswal
    Osiris Therapeutics, Inc, Baltimore, MD 21231 2001
    J Cell Biochem 64:295-312. 1997
  5. ncbi Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults
    Guy E Thwaites
    Oxford University Clinical Research Unit at the Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    N Engl J Med 351:1741-51. 2004
  6. pmc Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: an open-label randomised controlled trial
    S Vincent Rajkumar
    Mayo Clinic, Rochester, Minnesota, USA
    Lancet Oncol 11:29-37. 2010
  7. ncbi Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth
    D Roberts
    Liverpool Women s NHS Foundation Trust, Crown Street, Liverpool, Merseyside, UK L8 7SS
    Cochrane Database Syst Rev 3:CD004454. 2006
  8. ncbi Randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with macular edema due to retinal vein occlusion
    Julia A Haller
    Wills Eye Institute, Philadelphia, Pennsylvania 19107, USA
    Ophthalmology 117:1134-1146.e3. 2010
  9. ncbi Dexamethasone intravitreal implant in patients with macular edema related to branch or central retinal vein occlusion twelve-month study results
    Julia A Haller
    Wills Eye Institute, Philadelphia, Pennsylvania 19107, USA
    Ophthalmology 118:2453-60. 2011
  10. pmc A factorial trial of six interventions for the prevention of postoperative nausea and vomiting
    Christian C Apfel
    Julius Maximilians Universitat, Wurzburg, Germany
    N Engl J Med 350:2441-51. 2004

Detail Information

Publications387 found, 100 shown here

  1. ncbi Resetting of circadian time in peripheral tissues by glucocorticoid signaling
    A Balsalobre
    , Sciences II, , 30 Quai Ernest Ansermet, , Switzerland
    Science 289:2344-7. 2000
    ..Here, we show that the glucocorticoid hormone analog dexamethasone induces circadian gene expression in cultured rat-1 fibroblasts and transiently changes the phase of circadian ..
  2. pmc Genomic determination of the glucocorticoid response reveals unexpected mechanisms of gene regulation
    Timothy E Reddy
    HudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA
    Genome Res 19:2163-71. 2009
    ..and measured related changes in gene expression with mRNA sequencing in response to the glucocorticoid dexamethasone (DEX)...
  3. pmc TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice
    Laura McKinley
    Department of Pediatrics, Lung Immunology and Host Defense Laboratory, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Immunol 181:4089-97. 2008
    ..In vitro, T(H)17 cytokine responses were not sensitive to dexamethasone (DEX) treatment despite immunocytochemistry confirming glucocorticoid receptor translocation to the nucleus ..
  4. ncbi Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro
    N Jaiswal
    Osiris Therapeutics, Inc, Baltimore, MD 21231 2001
    J Cell Biochem 64:295-312. 1997
    ..MSCs derived from 2nd or 3rd passage were cultured for 16 days in various base media containing 1 to 1000 nM dexamethasone (Dex), 0.01 to 4 mM L-ascorbic acid-2-phosphate (AsAP) or 0...
  5. ncbi Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults
    Guy E Thwaites
    Oxford University Clinical Research Unit at the Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    N Engl J Med 351:1741-51. 2004
  6. pmc Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: an open-label randomised controlled trial
    S Vincent Rajkumar
    Mayo Clinic, Rochester, Minnesota, USA
    Lancet Oncol 11:29-37. 2010
    High-dose dexamethasone is a mainstay of therapy for multiple myeloma. We studied whether low-dose dexamethasone in combination with lenalidomide is non-inferior to and has lower toxicity than high-dose dexamethasone plus lenalidomide.
  7. ncbi Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth
    D Roberts
    Liverpool Women s NHS Foundation Trust, Crown Street, Liverpool, Merseyside, UK L8 7SS
    Cochrane Database Syst Rev 3:CD004454. 2006
    ..Respiratory distress syndrome (RDS) is a serious complication of preterm birth and the primary cause of early neonatal mortality and disability...
  8. ncbi Randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with macular edema due to retinal vein occlusion
    Julia A Haller
    Wills Eye Institute, Philadelphia, Pennsylvania 19107, USA
    Ophthalmology 117:1134-1146.e3. 2010
    To evaluate the safety and efficacy of dexamethasone intravitreal implant (DEX implant; OZURDEX, Allergan, Inc...
  9. ncbi Dexamethasone intravitreal implant in patients with macular edema related to branch or central retinal vein occlusion twelve-month study results
    Julia A Haller
    Wills Eye Institute, Philadelphia, Pennsylvania 19107, USA
    Ophthalmology 118:2453-60. 2011
    To evaluate the safety and efficacy of 1 or 2 treatments with dexamethasone intravitreal implant (DEX implant) over 12 months in eyes with macular edema owing to branch or central retinal vein occlusion (BRVO or CRVO).
  10. pmc A factorial trial of six interventions for the prevention of postoperative nausea and vomiting
    Christian C Apfel
    Julius Maximilians Universitat, Wurzburg, Germany
    N Engl J Med 350:2441-51. 2004
    ..Although many trials have been conducted, the relative benefits of prophylactic antiemetic interventions given alone or in combination remain unknown...
  11. ncbi Dexamethasone intravitreal implant for treatment of diabetic macular edema in vitrectomized patients
    David S Boyer
    Retina Vitreous Associates Medical Group, Los Angeles, California, USA
    Retina 31:915-23. 2011
    To evaluate the safety and efficacy of Ozurdex (dexamethasone intravitreal implant) 0.7 mg in the treatment of diabetic macular edema in vitrectomized eyes.
  12. pmc Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor
    Mauro Perretti
    1 Department of Biochemical Pharmacology, William Harvey Research Institute, Bart s and the London School of Medicine, Queen Mary University of London, Charterhouse Square, London, UK 2 M P and N C contributed equally to this paper
    Nat Med 8:1296-302. 2002
    Aspirin (ASA) and dexamethasone (DEX) are widely used anti-inflammatory agents yet their mechanism(s) for blocking polymorphonuclear neutrophil (PMN) accumulation at sites of inflammation remains unclear...
  13. ncbi The E3 Ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle
    Brian A Clarke
    Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, MA 02139, USA
    Cell Metab 6:376-85. 2007
    Skeletal muscle atrophy occurs as a side effect of treatment with synthetic glucocorticoids such as dexamethasone (DEX) and is a hallmark of cachectic syndromes associated with increased cortisol levels...
  14. ncbi Induction of Treg by monocyte-derived DC modulated by vitamin D3 or dexamethasone: differential role for PD-L1
    Wendy W J Unger
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 39:3147-59. 2009
    ..In this study we compared the tolerizing capacity of dexamethasone (Dex)- and 1 alpha,25-dihydroxyvitamin D3 (VD3)-modulated DC...
  15. pmc Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression
    Kazuhiro Ito
    Airway Disease Section, National Heart and Lung Institute, Imperial College, London SW3 6LY, England, UK
    J Exp Med 203:7-13. 2006
    ..Specific knockdown of HDAC2 by RNA interference resulted in reduced sensitivity to dexamethasone suppression of interleukin 1beta-induced granulocyte/macrophage colony-stimulating factor production...
  16. ncbi Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions
    Stephanie Ridder
    Division of Molecular Biology of the Cell I, German Cancer Research Center, D 69120 Heidelberg, Germany
    J Neurosci 25:6243-50. 2005
    ..patients, GR+/- mice have a disinhibited hypothalamic-pituitary-adrenal (HPA) system and a pathological dexamethasone/corticotropin-releasing hormone test...
  17. ncbi Differential protein pathways in 1,25-dihydroxyvitamin d(3) and dexamethasone modulated tolerogenic human dendritic cells
    Gabriela Bomfim Ferreira
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, University Hospital Gasthuisberg, Catholic University of Leuven, Herestraat 49, BOX 902, B 3000 Leuven, Belgium
    J Proteome Res 11:941-71. 2012
    ..the protein profile, function and phenotype of DCs obtained in vitro in the presence of 1,25(OH)(2)D(3), dexamethasone (DEX), and a combination of both compounds (combi)...
  18. ncbi Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
    C M Pariante
    Section of Clinical Neuropharmacology, Institute of Psychiatry, King's College London, London, United Kingdom
    Biol Psychiatry 49:391-404. 2001
    ..features of this HPA axis hyperactivity is reduced sensitivity to the inhibitory effects of the glucocorticoid dexamethasone on the production of adrenocorticotropic hormone and cortisol during the dexamethasone suppression test and, ..
  19. ncbi Prenatal glucocorticoid exposure in the sheep alters renal development in utero: implications for adult renal function and blood pressure control
    Karen M Moritz
    Department of Anatomy and Developmental Biology, Monash University, Clayton, Australia
    Am J Physiol Regul Integr Comp Physiol 301:R500-9. 2011
    ..Pregnant ewes were treated with saline (SAL), dexamethasone (DEX; 0.48 mg/h) or cortisol (CORT; 5 mg/h) over days 26-28 of gestation (term = 150 days)...
  20. ncbi A randomized phase 3 study on the effect of thalidomide combined with adriamycin, dexamethasone, and high-dose melphalan, followed by thalidomide maintenance in patients with multiple myeloma
    Henk M Lokhorst
    University Medical Center, Utrecht, The Netherlands
    Blood 115:1113-20. 2010
    ..A total of 556 patients was randomly assigned to arm A: 3 cycles of vincristine, adriamycin, and dexamethasone, or to arm B: thalidomide 200 mg orally, days 1 to 28 plus adriamycin and dexamethasone...
  21. ncbi A phase 2 study of bortezomib in relapsed, refractory myeloma
    Paul G Richardson
    Department of Adult Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    N Engl J Med 348:2609-17. 2003
    ..Bortezomib, a boronic acid dipeptide, is a novel proteasome inhibitor that has been shown in preclinical and phase 1 studies to have antimyeloma activity...
  22. ncbi Phagocytosis and clearance of apoptotic cells is mediated by MER
    R S Scott
    UNC Neuroscience Center, USA
    Nature 411:207-11. 2001
    ..Thus, the Mer receptor tyrosine kinase seems to be critical for the engulfment and efficient clearance of apoptotic cells. This has implications for inflammation and autoimmune diseases such as systemic lupus erythematosus...
  23. ncbi Modulation of phagocytosis of apoptotic neutrophils by supernatant from dexamethasone-treated macrophages and annexin-derived peptide Ac(2-26)
    Paola Maderna
    Department of Medicine and Therapeutics, The Conway Institute of Biomolecular and Biomedical Research, The Dublin Molecular Medicine Centre, University College Dublin, Dublin, Ireland
    J Immunol 174:3727-33. 2005
    ..role of endogenous annexin on clearance of apoptotic cells, Mphi were cultured for 5 days in the presence of dexamethasone. Supernatants collected from dexamethasone-treated Mphi significantly enhanced the ability of naive Mphi to ..
  24. ncbi Bortezomib with thalidomide plus dexamethasone compared with thalidomide plus dexamethasone as induction therapy before, and consolidation therapy after, double autologous stem-cell transplantation in newly diagnosed multiple myeloma: a randomised phase 3
    Michele Cavo
    Istituto di Ematologia Seragnoli, Universita degli Studi di Bologna, Bologna, Italy
    Lancet 376:2075-85. 2010
    Thalidomide plus dexamethasone (TD) is a standard induction therapy for myeloma...
  25. pmc BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone
    Jerome Moreaux
    Institut National de la Santé et de la Recherche Médicale U475 and Unité de Thérapie Cellulaire, Centre Hospitalier Universitaire Montpellier, Hopital St Eloi, France
    Blood 103:3148-57. 2004 the survival of primary myeloma cells cultured with their bone-marrow environment, and protected them from dexamethasone (DEX)-induced apoptosis...
  26. pmc Inhibition of lipopolysaccharide-stimulated chronic obstructive pulmonary disease macrophage inflammatory gene expression by dexamethasone and the p38 mitogen-activated protein kinase inhibitor N-cyano-N'-(2-{[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylph
    Lauren M Kent
    Education and Research Centre 2nd Floor Office, South Manchester University Hospitals Trust, Wythenshawe Hospital, Southmoor Road, Manchester M23 9LT, UK
    J Pharmacol Exp Ther 328:458-68. 2009
    ..SB706504) and dexamethasone on COPD macrophage inflammatory gene expression and protein secretion...
  27. ncbi Dexamethasone intravitreal implant for noninfectious intermediate or posterior uveitis
    Careen Lowder
    Cleveland Clinic Cole Eye Institute, 9500 Euclid Ave, i 32, Cleveland, OH 44195, USA
    Arch Ophthalmol 129:545-53. 2011
    To evaluate the safety and efficacy of 2 doses of dexamethasone intravitreal implant (DEX implant) for treatment of noninfectious intermediate or posterior uveitis.
  28. ncbi Combined dexamethasone/corticotropin releasing hormone test predicts treatment response in major depression - a potential biomarker?
    Marcus Ising
    Max Planck Institute of Psychiatry, Munich, Germany
    Biol Psychiatry 62:47-54. 2007
    Exaggerated corticotropin (ACTH) and cortisol response to the combined dexamethasone (DEX)/corticotropin releasing hormone (CRH) test, indicating impaired regulation of the hypothalamus-pituitary-adrenocortical (HPA) system, is ..
  29. ncbi Randomized, multicenter, phase 2 study (EVOLUTION) of combinations of bortezomib, dexamethasone, cyclophosphamide, and lenalidomide in previously untreated multiple myeloma
    Shaji Kumar
    Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA
    Blood 119:4375-82. 2012
    Combinations of bortezomib (V) and dexamethasone (D) with either lenalidomide (R) or cyclophosphamide (C) have shown significant efficacy...
  30. ncbi Bortezomib or high-dose dexamethasone for relapsed multiple myeloma
    Paul G Richardson
    Dana Farber Cancer Institute, Boston, MA 02115, USA
    N Engl J Med 352:2487-98. 2005
    This study compared bortezomib with high-dose dexamethasone in patients with relapsed multiple myeloma who had received one to three previous therapies.
  31. pmc Cyclophosphamide, thalidomide, and dexamethasone (CTD) as initial therapy for patients with multiple myeloma unsuitable for autologous transplantation
    Gareth J Morgan
    Institute of Cancer Research, Royal Marsden Hospital, London, United Kingdom
    Blood 118:1231-8. 2011
    ..the randomized MRC Myeloma IX trial, we compared an attenuated regimen of cyclophosphamide, thalidomide, and dexamethasone (CTDa; n = 426) with melphalan and prednisolone (MP; n = 423) in patients with newly diagnosed multiple ..
  32. pmc Glucocorticoid sensitivity of lipopolysaccharide-stimulated chronic obstructive pulmonary disease alveolar macrophages
    J Armstrong
    University of Manchester, NIHR Translational Research Facility, University Hospital of South Manchester Foundation Trust, Manchester, UK
    Clin Exp Immunol 158:74-83. 2009
    ..15 COPD patients, nine smokers (S) and nine healthy non-smokers (HNS) were stimulated with LPS with or without dexamethasone (100 and 1000 nM)...
  33. ncbi Bortezomib plus dexamethasone induction improves outcome of patients with t(4;14) myeloma but not outcome of patients with del(17p)
    Herve Avet-Loiseau
    Centre Hospitalier Universitaire, Nantes, France
    J Clin Oncol 28:4630-4. 2010
    ..Patients presenting with either t(4;14) or del(17p) are known to have a short event-free survival (EFS) and overall survival (OS). Some preliminary data suggest that bortezomib is able to overcome these prognostic parameters...
  34. ncbi Dexamethasone and length of hospital stay in patients with community-acquired pneumonia: a randomised, double-blind, placebo-controlled trial
    Sabine C A Meijvis
    Department of Internal Medicine, St Antonius Hospital, Nieuwegein, Netherlands
    Lancet 377:2023-30. 2011
    ..We aimed to assess effect of addition of dexamethasone on length of stay in this group, which might result in earlier resolution of pneumonia through dampening of ..
  35. pmc Bortezomib, dexamethasone, cyclophosphamide and lenalidomide combination for newly diagnosed multiple myeloma: phase 1 results from the multicenter EVOLUTION study
    S K Kumar
    Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA
    Leukemia 24:1350-6. 2010
    ..conducted to determine the maximum tolerated dose (MTD) of cyclophosphamide in combination with bortezomib, dexamethasone and lenalidomide (VDCR) and to assess the safety and efficacy of this combination in untreated multiple ..
  36. ncbi Antiemetics: American Society of Clinical Oncology clinical practice guideline update
    Ethan Basch
    Memorial Sloan Kettering Cancer Center, New York, USA
    J Clin Oncol 29:4189-98. 2011
    ..To update the American Society of Clinical Oncology (ASCO) guideline for antiemetics in oncology...
  37. pmc The combined dexamethasone/CRH Test (DEX/CRH test) and prediction of acute treatment response in major depression
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany
    PLoS ONE 4:e4324. 2009
    In this study the predictive value of the combined dexamethasone/CRH test (DEX/CRH test) for acute antidepressant response was investigated.
  38. pmc Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor
    A Ray
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520
    Proc Natl Acad Sci U S A 91:752-6. 1994
    ..interleukin 6 promoter by a combination of the factor NF-IL6 and the p65 subunit of NF-kappa B is inhibited by dexamethasone (ligand)-activated glucocorticoid receptor...
  39. ncbi Bortezomib plus dexamethasone is superior to vincristine plus doxorubicin plus dexamethasone as induction treatment prior to autologous stem-cell transplantation in newly diagnosed multiple myeloma: results of the IFM 2005-01 phase III trial
    Jean Luc Harousseau
    Centre Rene Gauducheau, Nantes St Herblain, France
    J Clin Oncol 28:4621-9. 2010
    To compare efficacy and safety of bortezomib plus dexamethasone and vincristine plus doxorubicin plus dexamethasone (VAD) as induction before stem-cell transplantation in previously untreated myeloma.
  40. ncbi Randomized controlled clinical trial of a combination of somatostatin analog and dexamethasone plus zoledronate vs. zoledronate in patients with androgen ablation-refractory prostate cancer
    Constantine S Mitsiades
    Department of Experimental Physiology, Medical School, University of Athens, Goudi Athens, Attiki 115 27, Greece
    Anticancer Res 26:3693-700. 2006
    As previously shown, the combination of standard androgen ablation therapy with somatostatin analog and dexamethasone in metastatic androgen ablation-refractory (stage D3) prostate cancer (PrCa) patients has a favorable profile of side-..
  41. ncbi Intergenerational consequences of fetal programming by in utero exposure to glucocorticoids in rats
    Amanda J Drake
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Molecular Medicine Center, Western General Hospital, United Kingdom
    Am J Physiol Regul Integr Comp Physiol 288:R34-8. 2005
    ..We have explored intergenerational effects in the dexamethasone-programmed rat, a model in which fetal exposure to excess glucocorticoid results in low birth weight with ..
  42. ncbi Suppression of cytokine expression by roflumilast and dexamethasone in a model of chronic asthma
    C Herbert
    Department of Pathology, School of Medical Sciences, University of New South Wales, Sydney, Australia
    Clin Exp Allergy 38:847-56. 2008
    In a mouse model of mild chronic asthma, both inflammation and remodelling can be suppressed by dexamethasone (a glucocorticoid) and roflumilast (a selective phosphodiesterase-4 inhibitor).
  43. ncbi Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse
    Robert Hannon
    Department of Biochemical Pharmacology, William Harvey Research Institute, Queen Mary, University of London, Charterhouse Square, EC1M 6BQ, UK
    FASEB J 17:253-5. 2003
    ..There are also gender differences in activated leukocyte behavior in the Anx-1-/- mice that are not seen in the wild-type animals, suggesting an interaction between sex hormones and inflammation in Anx-1-/- animals...
  44. pmc Increased manganese superoxide dismutase expression or treatment with manganese porphyrin potentiates dexamethasone-induced apoptosis in lymphoma cells
    Melba C Jaramillo
    Department of Pathology, University of Arizona, Tucson, Arizona 85724, USA
    Cancer Res 69:5450-7. 2009
    ..In primary follicular lymphoma cells, MnTE-2-PyP(5+) increased cell death due to dexamethasone. Treatment of H9c2 cardiomyocytes with MnTE-2-PyP(5+) inhibited doxorubicin cytotoxicity...
  45. ncbi Dexamethasone-induced gene 2 (dig2) is a novel pro-survival stress gene induced rapidly by diverse apoptotic signals
    Zhengqi Wang
    Department of Medicine, Comprehensive Cancer Center, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Biol Chem 278:27053-8. 2003
    ..This process requires de novo RNA/protein synthesis. Here we report the identification and cloning of a novel dexamethasone-induced gene designated dig2...
  46. ncbi Bortezomib plus dexamethasone versus reduced-dose bortezomib, thalidomide plus dexamethasone as induction treatment before autologous stem cell transplantation in newly diagnosed multiple myeloma
    Philippe Moreau
    University Hospital, Nantes, France
    Blood 118:5752-8; quiz 5982. 2011
    The Intergroupe Francophone du Myelome conducted a randomized trial to compare bortezomib-dexamethasone (VD) as induction before high-dose therapy (HDT) and autologous stem cell transplantation (ASCT) to a combination consisting of ..
  47. pmc Ligand-independent phosphorylation of the glucocorticoid receptor integrates cellular stress pathways with nuclear receptor signaling
    Amy Jo Galliher-Beckley
    Molecular Endocrinology Group, Laboratory of Signal Transduction, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Mol Cell Biol 31:4663-75. 2011
    ..This posttranslational modification allows prior cellular stress signals to dictate the transcriptional response to glucocorticoids...
  48. ncbi Proliferation, differentiation and gene expression of osteoblasts in boron-containing associated with dexamethasone deliver from mesoporous bioactive glass scaffolds
    Chengtie Wu
    Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, People s Republic of China
    Biomaterials 32:7068-78. 2011
    ..Furthermore, the effect of dexamethasone (DEX) delivery in B-MBG scaffold system was investigated on the proliferation, differentiation and bone-..
  49. pmc Dexamethasone ameliorates renal ischemia-reperfusion injury
    Sanjeev Kumar
    Centre for Translational Medicine and Therapeutics, William Harvey Research Institute, St Bartholomew s, University of London, London EC1M 6BQ, United Kingdom
    J Am Soc Nephrol 20:2412-25. 2009
    ..In rat renal IRI, a single dose of dexamethasone administered before ischemia, or at the onset of reperfusion, ameliorated biochemical and histologic acute ..
  50. ncbi Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo
    Min H Kang
    Developmental Therapeutics Program, Childrens Hospital Los Angeles and University of Southern California Institute for Pediatric Clinical Research, Los Angeles, CA 90027, USA
    Blood 110:2057-66. 2007
    ..We evaluated the cytotoxicity of ABT-737 in combination with vincristine, dexamethasone, and L-asparaginase (VXL) in 7 ALL cell lines...
  51. pmc Complex human glucocorticoid receptor dim mutations define glucocorticoid induced apoptotic resistance in bone cells
    Christine M Jewell
    National Institute of Environmental Health Sciences National Institutes of Health, Laboratory of Signal Transduction, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 26:244-56. 2012
    ..These studies challenge conclusions drawn from previous studies of GR dim mutants...
  52. pmc Novel phosphatidylinositol 3-kinase inhibitor NVP-BKM120 induces apoptosis in myeloma cells and shows synergistic anti-myeloma activity with dexamethasone
    Yuhuan Zheng
    Department of Lymphoma Myeloma, Division of Cancer Medicine, Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Mol Med (Berl) 90:695-706. 2012
    ..In addition, BKM120 shows synergistic cytotoxicity with dexamethasone in dexamethasone-sensitive MM cells...
  53. pmc Dexamethasone stimulated gene expression in peripheral blood is a sensitive marker for glucocorticoid receptor resistance in depressed patients
    Andreas Menke
    Moleculargenetics of Affective Disorders, Max Planck Institute of Psychiatry, Kraepelinstr, Munich, Germany
    Neuropsychopharmacology 37:1455-64. 2012
    ..using baseline gene expression profiles have provided mixed results, our approach was to use an in vivo dexamethasone challenge test and to compare glucocorticoid receptor (GR)-mediated changes in gene expression between ..
  54. ncbi PANORAMA 2: panobinostat in combination with bortezomib and dexamethasone in patients with relapsed and bortezomib-refractory myeloma
    Paul G Richardson
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA
    Blood 122:2331-7. 2013
    ..PANORAMA 2 is a phase 2 trial of panobinostat in combination with bortezomib and dexamethasone to treat patients with relapsed and bortezomib-refractory multiple myeloma (with ≥2 prior lines of therapy, ..
  55. ncbi Clinical and pharmacodynamic evaluation of metronomic cyclophosphamide, celecoxib, and dexamethasone in advanced hormone-refractory prostate cancer
    Andrea Fontana
    Division of Medical Oncology, Azienda USL 6 of Livorno, Italy
    Clin Cancer Res 15:4954-62. 2009
    ..v. standard dose of cyclophosphamide (CTX) immediately followed by an oral metronomic CTX regimen with celecoxib (CXB) and dexamethasone (DEX) in advanced hormone-refractory prostate cancer patients.
  56. ncbi Extended follow-up of a phase 2 trial of bortezomib alone and in combination with dexamethasone for the frontline treatment of multiple myeloma
    Sundar Jagannath
    St Vincent s Comprehensive Cancer Center, New York, NY 10011, USA
    Br J Haematol 146:619-26. 2009
    ..on the extended follow-up of a phase II study in frontline MM of bortezomib alone and in combination with dexamethasone. Forty-nine previously untreated, symptomatic MM patients received bortezomib 1...
  57. ncbi Effects of round window dexamethasone on residual hearing in a Guinea pig model of cochlear implantation
    David P James
    Department of Otolaryngology, University of Melbourne, Parkville, Australia
    Audiol Neurootol 13:86-96. 2008
    ..Thirty minutes prior to implantation, a hyaluronic acid/carboxymethylcellulose bead, loaded with either dexamethasone or normal saline, was placed upon the round window membrane...
  58. ncbi Enhanced cortisol suppression to dexamethasone associated with Gulf War deployment
    Julia A Golier
    Department of Psychiatry, James J Peters VA Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Psychoneuroendocrinology 31:1181-9. 2006
    To examine whether PTSD or post-deployment health symptoms in veterans of the first Gulf War (Operation Desert Shield/Storm) are associated with enhanced suppression of the pituitary-adrenal axis to low-dose dexamethasone (DEX).
  59. ncbi Pomalidomide plus low-dose dexamethasone versus high-dose dexamethasone alone for patients with relapsed and refractory multiple myeloma (MM-003): a randomised, open-label, phase 3 trial
    Jesus San Miguel
    Hospital e Instituto Biosanitario de Salamanca IBSAL, Universidad de Salamanca IBMCC CSIC, Salamanca, Spain Clínica Universidad de Navarra, Pamplona, Spain Electronic address
    Lancet Oncol 14:1055-66. 2013 patients with relapsed multiple myeloma, but synergistic effects have been noted when combined with dexamethasone. We compared the efficacy and safety of pomalidomide plus low-dose dexamethasone with high-dose dexamethasone ..
  60. ncbi Proteasome-mediated glucocorticoid receptor degradation restricts transcriptional signaling by glucocorticoids
    A D Wallace
    Molecular Endocrinology Group, Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 276:42714-21. 2001
    ..inhibitor MG-132 effectively blocks glucocorticoid receptor protein down-regulation by the glucocorticoid dexamethasone. Interestingly, both MG-132 and a second proteasome inhibitor beta-lactone significantly enhanced hormone ..
  61. ncbi The effect of combining dexamethasone with ondansetron for nausea and vomiting associated with fentanyl-based intravenous patient-controlled analgesia
    J W Song
    Department of Anaesthesiology and Pain Medicine and Anaesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea
    Anaesthesia 66:263-7. 2011
    We investigated whether combined dexamethasone and ondansetron is more effective than ondansetron alone in preventing postoperative nausea and vomiting in patients with fentanyl-based intravenous patient-controlled analgesia...
  62. pmc Prenatal dexamethasone programs hypertension and renal injury in the rat
    Luis A Ortiz
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75235 9063, USA
    Hypertension 41:328-34. 2003
    b>Dexamethasone is frequently administered to the developing fetus to accelerate pulmonary development...
  63. ncbi Perifosine plus bortezomib and dexamethasone in patients with relapsed/refractory multiple myeloma previously treated with bortezomib: results of a multicenter phase I/II trial
    Paul G Richardson
    Dana Farber Cancer Institute, 44 Binney St, Dana 1B02, Boston, MA 02115, USA
    J Clin Oncol 29:4243-9. 2011
    ..Preclinical data show that the novel signal transduction modulator, perifosine, enhances the cytotoxicity of dexamethasone and bortezomib...
  64. ncbi Glucocorticoid-induced degradation of glycogen synthase kinase-3 protein is triggered by serum- and glucocorticoid-induced protein kinase and Akt signaling and controls beta-catenin dynamics and tight junction formation in mammary epithelial tumor cells
    Kim L Failor
    Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720 3200, USA
    Mol Endocrinol 21:2403-15. 2007
    ..We now demonstrate that treatment with the synthetic glucocorticoid dexamethasone induces the ubiquitin-26S proteasome-mediated degradation of GSK3 protein with no change in GSK3 transcript ..
  65. pmc Clarithromycin (Biaxin)-lenalidomide-low-dose dexamethasone (BiRd) versus lenalidomide-low-dose dexamethasone (Rd) for newly diagnosed myeloma
    Francesca Gay
    Division of Hematology, Department of Internal Medicine, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Am J Hematol 85:664-9. 2010
    ..was to compare the efficacy and toxicity of the addition of clarithromycin (Biaxin) to lenalidomide/low-dose dexamethasone (BiRd) vs. lenalidomide/low-dose dexamethasone (Rd) for newly diagnosed myeloma...
  66. ncbi Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB
    E Ayroldi
    Department of Clinical and Experimental Medicine, Section of Pharmacology, University of Perugia, Via del Giochetto, 06100 Perugia, Italy
    Blood 98:743-53. 2001
    ..was identified that encodes a glucocorticoid-induced leucine zipper (GILZ) whose expression is up-regulated by dexamethasone. This study analyzed the role of GILZ in the control of T-cell activation and its possible interaction with ..
  67. ncbi Major tumor shrinking and persistent molecular remissions after consolidation with bortezomib, thalidomide, and dexamethasone in patients with autografted myeloma
    Marco Ladetto
    Cattedra di Ematologia, Via Genova 3, 10126 Torino, Italy
    J Clin Oncol 28:2077-84. 2010
    ..polymerase chain reaction (RQ-PCR), of a consolidation regimen that included bortezomib, thalidomide, and dexamethasone (VTD) in patients with multiple myeloma (MM) responding to autologous stem-cell transplantation (auto-SCT)...
  68. ncbi Osteoblastogenic effects of dexamethasone through upregulation of TAZ expression in rat mesenchymal stem cells
    Dun Hong
    Institute of Cell Biology, Medical College of Zhejiang University, 388 Yuhangtang Road, Hangzhou 310058, Zhejiang Province, China
    J Steroid Biochem Mol Biol 116:86-92. 2009
    ..b>Dexamethasone (DEX), a synthetic and widely used glucocorticoid, affects osteogenesis...
  69. ncbi Regulation of tristetraprolin expression by interleukin-1 beta and dexamethasone in human pulmonary epithelial cells: roles for nuclear factor-kappa B and p38 mitogen-activated protein kinase
    Elizabeth M King
    Airways Inflammation Group, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Pharmacol Exp Ther 330:575-85. 2009
    ..By contrast, and despite a 3- to 4-fold induction of TTP mRNA, the anti-inflammatory glucocorticoid dexamethasone only modestly induced expression of the approximately 40-kDa form of TTP...
  70. ncbi Effects of loteprednol/tobramycin versus dexamethasone/tobramycin on intraocular pressure in healthy volunteers
    Edward J Holland
    Cincinnati Eye Institute and University of Cincinnati, Cincinnati, OH, USA
    Cornea 27:50-5. 2008
    To compare the steroid-induced intraocular pressure (IOP) and other ocular adverse effects of loteprednol etabonate 0.5% and tobramycin 0.3% ophthalmic suspension with those of dexamethasone 0.1% and tobramycin 0.3% ophthalmic suspension.
  71. ncbi The combined dexamethasone/CRH test as a potential surrogate marker in depression
    Marcus Ising
    Max Planck Institute of Psychiatry, Kraepelinstr 10, D 80804 Munich, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 29:1085-93. 2005 a dysfunctional stress hormone regulation, which can be most sensitively detected with the combined dexamethasone (dex)/corticotropin releasing hormone (CRH) test...
  72. ncbi Efficacy of L-asparaginase with methotrexate and dexamethasone (AspaMetDex regimen) in patients with refractory or relapsing extranodal NK/T-cell lymphoma, a phase 2 study
    Arnaud Jaccard
    Service d Hématologie et de Thérapie Cellulaire, Centre Hospitalier Universitaire CHU Limoges, Université et Centre National de la Recherche Scientifique CNRS, Unité Mixte de Recherche UMR 6101, Limoges, France
    Blood 117:1834-9. 2011
    ..First-line L-asparaginase combination therapy for extranodal NK/T-cell lymphoma warrants evaluation in prospective trials. This trial is registered at as #NCT00283985...
  73. pmc Macrophage glucocorticoid receptors regulate Toll-like receptor 4-mediated inflammatory responses by selective inhibition of p38 MAP kinase
    Sandip Bhattacharyya
    Departments of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Blood 109:4313-9. 2007
    ..Ex vivo, treatment with dexamethasone (Dex) markedly inhibited LPS-mediated induction of inflammatory genes in control but not GR-deficient ..
  74. ncbi p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa
    Andreas Villunger
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Science 302:1036-8. 2003
    ..Hence, Puma and Noxa are critical mediators of the apoptotic responses induced by p53 and other agents...
  75. ncbi Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy
    E Laane
    Department of Oncology and Pathology, Cancer Centre Karolinska R8 03, Karolinska Institutet and Karolinska University Hospital, Stockholm S 171 76, Sweden
    Cell Death Differ 16:1018-29. 2009
    ..We show that dexamethasone induced autophagy upstream of apoptosis in acute lymphoblastic leukemia cells...
  76. pmc Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma
    Paul G Richardson
    Dana Farber Cancer Institute, Boston, MA 02115, USA
    Blood 116:679-86. 2010
    This phase 1/2 study is the first prospective evaluation of lenalidomide-bortezomib-dexamethasone in front-line myeloma. Patients (N = 66) received 3-week cycles (n = 8) of bortezomib 1.0 or 1...
  77. ncbi Glucocorticoids stimulate human sgk1 gene expression by activation of a GRE in its 5'-flanking region
    Omar A Itani
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52246, USA
    Am J Physiol Endocrinol Metab 283:E971-9. 2002
    ..We conclude that GCs stimulate sgk1 expression in human epithelial cells via activation of a GRE in the 5'-flanking region of sgk1...
  78. ncbi Dexamethasone treatment attenuates early seawater instillation-induced acute lung injury in rabbits
    Ding Xinmin
    Department of Respiratory Disease, Naval General Hospital of PLA, Beijing 100037, China
    Pharmacol Res 53:372-9. 2006
    ..Therefore, this study aimed to investigate whether dexamethasone treatment can attenuate seawater instillation-induced acute lung injury in rabbits...
  79. ncbi Analyzing corticosterone metabolites in fecal samples of mice: a noninvasive technique to monitor stress hormones
    Chadi Touma
    Department of Behavioural Biology, University of Muenster, D 48149 Muenster, Germany
    Horm Behav 45:10-22. 2004
    ..Two adrenocorticotropic hormone (ACTH) challenge tests, two dexamethasone (Dex) suppression tests and two control experiments [investigating effects of the injection procedure itself ..
  80. ncbi FHL2 mediates dexamethasone-induced mesenchymal cell differentiation into osteoblasts by activating Wnt/beta-catenin signaling-dependent Runx2 expression
    Zahia Hamidouche
    INSERM U606, Hopital Lariboisiere, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France
    FASEB J 22:3813-22. 2008
    ..of the LIM protein superfamily, that is up-regulated during early osteoblast differentiation induced by dexamethasone in murine and human MSCs...
  81. ncbi Adverse neonatal outcomes associated with antenatal dexamethasone versus antenatal betamethasone
    Ben H Lee
    Division of Neonatal Perinatal Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Pediatrics 117:1503-10. 2006
    Antenatal dexamethasone and betamethasone may not be equally efficacious in the prevention of adverse neonatal outcomes...
  82. ncbi Effects of transforming growth factor beta1 and dexamethasone on the growth and chondrogenic differentiation of adipose-derived stromal cells
    Hani A Awad
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Tissue Eng 9:1301-12. 2003
    ..bovine serum (FBS) and treated with different doses and combinations of TGF-beta1 (0, 1, and 10 ng/mL) and dexamethasone (0, 10, and 100 nM)...
  83. ncbi Effect of dexamethasone on adipocyte differentiation markers and tumour necrosis factor-alpha expression in human PAZ6 cells
    V Zilberfarb
    Institute Cochin of Molecular Genetics, Paris, France
    Diabetologia 44:377-86. 2001
    ..We therefore studied the effect of dexamethasone on TNF-alpha expression and adipocyte differentiation in human PAZ6 cells...
  84. ncbi Dexamethasone prevents long-lasting learning impairment following a combination of lipopolysaccharide and hypoxia-ischemia in neonatal rats
    Tomoaki Ikeda
    Department of Obstetrics and Gynecology, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan
    Am J Obstet Gynecol 192:719-26. 2005
    ..We administered dexamethasone (DEX), a synthetic corticosteroid anti-inflammatory drug, to neonatal rats in a model of such damage induced ..
  85. ncbi Protein kinase B-alpha inhibits human pyruvate dehydrogenase kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors
    Hye Sook Kwon
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Diabetes 53:899-910. 2004
    ..Treatment of HepG2 cells with dexamethasone increases the relative abundance of PDK4 mRNA, and insulin blocks this effect...
  86. ncbi Lung-targeting delivery of dexamethasone acetate loaded solid lipid nanoparticles
    Qing Yu Xiang
    Key Laboratory of Drug Targeting of Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, P R China
    Arch Pharm Res 30:519-25. 2007
    ..of the present study was to develop a novel solid lipid nanoparticle (SLN) for the lung-targeting delivery of dexamethasone acetate (DXM) by intravenous administration...
  87. pmc Effect of prenatal dexamethasone on rat renal development
    L A Ortiz
    Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, Texas 75235-9063, USA
    Kidney Int 59:1663-9. 2001
    BACKGROUND: Prenatal insults can program the developing fetus to develop diseases that manifest in later life. Dexamethasone is often administered to the developing fetus to accelerate pulmonary development...
  88. doi Chemotherapy-induced nausea and vomiting
    Paul J Hesketh
    Caritas St Elizabeth s Medical Center, Boston, MA 02135, USA
    N Engl J Med 358:2482-94. 2008
  89. pmc Fast feedback inhibition of the HPA axis by glucocorticoids is mediated by endocannabinoid signaling
    Nathan K Evanson
    Department of Psychiatry, University of Cincinnati, GRI E205 ML 0506, 2170 E Galbraith Road, Cincinnati, Ohio 45237, USA
    Endocrinology 151:4811-9. 2010
    ..Local infusion of dexamethasone or a membrane-impermeant dexamethasone-BSA conjugate into the PVN rapidly inhibits restraint-induced ACTH and ..
  90. ncbi Bortezomib, doxorubicin and dexamethasone in advanced multiple myeloma
    A Palumbo
    Divisione di Ematologia dell Universita di Torino, Azienda Ospedaliera S Giovanni Battista, Torino, Italy
    Ann Oncol 19:1160-5. 2008
    Bortezomib has shown significant activity in myeloma. In this multicenter trial, we assessed for the first time the combination of bortezomib, doxorubicin and low-dose dexamethasone (PAd) in the treatment of relapsed/refractory myeloma.
  91. ncbi Treatment of patients with relapsed/refractory multiple myeloma with lenalidomide and dexamethasone with or without bortezomib: prospective evaluation of the impact of cytogenetic abnormalities and of previous therapies
    M A Dimopoulos
    Department of Clinical Therapeutics, University of Athens School of Medicine, Athens, Greece
    Leukemia 24:1769-78. 2010
    ..cytogenetic abnormalities (CAs) in patients with relapsed/refractory myeloma who received lenalidomide and dexamethasone (RD) with or without the addition of bortezomib (V)...
  92. ncbi Repeated pulse of methylprednisolone and cyclophosphamide with continuous dexamethasone therapy for patients with severe paraquat poisoning
    Ja Liang Lin
    Division of Clinical Toxicology and Nephrology, Department of Medicine, Chang Gung Memorial Hospital, Lin Kou Medical Center, Chang Gung University, School of Medicine, Taipei, Taiwan, ROC
    Crit Care Med 34:368-73. 2006
    ..with methylprednisolone (1 g/day for 3 days) and cyclophosphamide (15 mg/kg/day for 2 days), followed by dexamethasone 20 mg/day until Pao2 was >11...
  93. ncbi The dexamethasone/corticotropin-releasing factor test in men with major depression: role of childhood trauma
    Christine Heim
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 63:398-405. 2008
    The dexamethasone/corticotropin-releasing factor (CRF) test is considered to be the most sensitive measure of hypothalamic-pituitary-adrenal (HPA) axis hyperactivity and has been demonstrated to be altered in patients with major ..
  94. ncbi Glucocorticoids affect human dendritic cell differentiation and maturation
    L Piemonti
    Laboratory of Experimental Surgery, Surgical Department, S Raffaele Scientific Institute, Milan, Italy
    J Immunol 162:6473-81. 1999
    ..DC were differentiated from human monocytes by culture with GM-CSF and IL-4 for 7 days with and without dexamethasone (Dex)...
  95. ncbi Pomalidomide (CC4047) plus low-dose dexamethasone as therapy for relapsed multiple myeloma
    Martha Q Lacy
    Division of Hematology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Clin Oncol 27:5008-14. 2009
    ..We report, to our knowledge, the first phase II trial of pomalidomide administered in combination with low-dose dexamethasone for the treatment of relapsed or refractory multiple myeloma.
  96. ncbi Glucocorticoid regulation of the promoter of 11beta-hydroxysteroid dehydrogenase type 1 is indirect and requires CCAAT/enhancer-binding protein-beta
    Shuji Sai
    Endocrinology Unit, Centre for Cardiovascular Sciences, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom
    Mol Endocrinol 22:2049-60. 2008
    ..exploiting an A549 cell model system in which endogenous 11beta-HSD1 is expressed and is induced by dexamethasone. We show that glucocorticoid induction of 11beta-HSD1 is indirect and requires new protein synthesis...
  97. pmc Lenalidomide and high-dose dexamethasone compared with dexamethasone as initial therapy for multiple myeloma: a randomized Southwest Oncology Group trial (S0232)
    Jeffrey A Zonder
    Division of Hematology Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Blood 116:5838-41. 2010
    The Southwest Oncology Group conducted a randomized trial comparing lenalidomide (LEN) plus dexamethasone (DEX; n = 97) to placebo (PLC) plus DEX (n = 95) in newly diagnosed myeloma...
  98. ncbi A new dexamethasone-induced gene of the leucine zipper family protects T lymphocytes from TCR/CD3-activated cell death
    F D'Adamio
    Department of Clinical Medicine, Pathology and Pharmacology, University of Perugia, Italy
    Immunity 7:803-12. 1997
    By comparing mRNA species expressed in dexamethasone (DEX)-treated and untreated murine thymocytes, we have identified a gene, glucocorticoid-induced leucine zipper (GILZ), encoding a new member of the leucine zipper family...
  99. ncbi Influence of cytogenetics in patients with relapsed or refractory multiple myeloma treated with lenalidomide plus dexamethasone: adverse effect of deletion 17p13
    Donna Reece
    Division of Oncology, Princess Margaret Hospital, Toronto, Ontario, Canada
    Blood 114:522-5. 2009
    Although the combination of lenalidomide and dexamethasone is effective therapy for patients with relapsed/refractory multiple myeloma, the influence of high-risk cytogenetic abnormalities on outcomes is unknown...
  100. pmc GILZ mediates the antiproliferative activity of glucocorticoids by negative regulation of Ras signaling
    Emira Ayroldi
    Department of Clinical and Experimental Medicine, Section of Pharmacology, University of Perugia, Perugia, Italy
    J Clin Invest 117:1605-15. 2007
    Tsc22d3 coding for glucocorticoid-induced leucine zipper (GILZ) was initially identified as a dexamethasone-responsive gene involved in the control of T lymphocyte activation and apoptosis...
  101. ncbi Corticosteroid-induced kidney dysmorphogenesis is associated with deregulated expression of known cystogenic molecules, as well as Indian hedgehog
    Shun Kai Chan
    Nephro Urology, University College London Institute of Child Health, London, United Kingdom
    Am J Physiol Renal Physiol 298:F346-56. 2010
    ..4 or 14 microM) underwent a dose-dependant deceleration of overall growth accompanied by cyst formation. Dexamethasone, a glucocorticoid, reproduced these outcomes, but aldosterone, a mineralocorticoid, did not...

Research Grants73

  1. Regulation of HSV-1 Gene Expression and Replication by Nuclear Hormone Receptors
    SHAOCHUNG VICTOR HSIA; Fiscal Year: 2013
    ..Fifth, standard procedures used to induce HSV-1 reactivation, such as hyperthermia and dexamethasone treatment, also decrease TH levels...
  2. Steroid Responsive Mechanisms in the Ear
    DENNIS ROYAL TRUNE; Fiscal Year: 2012
    Project Summary Glucocorticoids (prednisone, methlyprednisolone, dexamethasone) have been employed for decades for control of hearing loss...
  3. Drug Interactions at the Human Blood-Brain Barrier
    Jashvant D Unadkat; Fiscal Year: 2010
    ..Third, it would indicate that drugs that are potent P-gp inducers (e.g. St. John's Wort, dexamethasone, rifabutin) must be avoided when co-administered with P-gp substrate drugs targeted to the brain...
  4. Chemokine Decoy Receptor: a novel therapy of IBD
    Kanneganti Murthy; Fiscal Year: 2012
    ..Treatment with mR-421 (3, 10, and 30 mg/kg/day QD IP), an irrelevant IgG control (10 mg/kg QD IP), dexamethasone (1 mg/kg QD IP), or anti-murine TNF-? (10 mg/kg QD IP) will begin 7 days after the start of oral DSS or ..
  5. C/EBP, atrogin-1, and muscle wasting
    Per Olof Hasselgren; Fiscal Year: 2009
    ..of histone deacetylase (HDAC) 3 and 6 expression and activity in skeletal muscle;3) sepsis in rats and dexamethasone treatment of cultured muscle cells result in p300-dependent acetylation of C/EBP[unreadable]; and 4) sepsis in ..
  6. Transscleral Transport & Polymeric Delivery of Antibody & Steroids for Macular Ed
    Ashim K Mitra; Fiscal Year: 2010
    ..the specific aims of this new grant application are: (1) to determine transscleral permeability of steroids (dexamethasone and prednisolone) and anti-VEGF monoclonal antibody (bevacizumab) (i) alone (ii) encapsulated in unmodified ..
  7. Sleep in Rats: From Conceptualization to Measurement, Analysis and Interpretation
    Gayle Giboney Page; Fiscal Year: 2010
    ..Additional outcomes at euthanasia include pro-inflammatory cytokine levels, and dexamethasone suppression of lipopolysaccharide-induced pro-inflammatory cytokine production in whole blood...
  8. 3D Differentiation of Mesenchymal Stem Cells in Peptide Amphiphile Matrices
    John B Matson; Fiscal Year: 2011
    ..PAs will be outfitted with dexamethasone (Dex) bound to the PA via a hydrolysable hydrazone linkage...
  9. The effects of dexamethasone on tumor and microglial cells in glioma
    TERREIA SUTTON JONES; Fiscal Year: 2013
    ..Corticoisteroids such as dexamethasone (Dex) have remained the standard of care for resolving brain tumor-associated neurological symptoms for ..
  10. Model systems for hematologic disorders caused by ribosomal protein deficiency
    George Thomas; Fiscal Year: 2010
    ..cells depleted of either small or large ribosomal subunit proteins;Aim2: Determine the effects of dexamethasone, lenalidomide, and leucine on the p53 response and on rpL5 and rpL11 translation in primary human ..
  11. Mechanisms of comorbidity between epilepsy and depression
    Andrey M Mazarati; Fiscal Year: 2013
    ..This will be achieved by measuring, using radioimmunoassay, both basal and dexamethasone/corticotropine releasing hormone (DEX/CRH)- induced increase of plasma corticosterone (CORT) levels during ..
  12. Endogenous Hemoglobin And Heme Detoxification After Intracerebral Hemorrhage
    Xiurong Zhao; Fiscal Year: 2013 Nrf2, whereas CD163 and CD91 expression is promoted by macrophage colony-stimulating factor (M-CSF) or Dexamethasone (DEX)...
  13. Exploiting Protease-Activatable Agents to Characterize and Treat Asthma
    Csilla Felsen; Fiscal Year: 2013
    ..efficacy of asthma therapeutic agents by attaching ACPPs to glucocorticoids and protease inhibitors, such as dexamethasone and marimastat, respectively, and administering them intravenously or intranasally to mice during antigen ..
  14. BDNF-Trk Signaling &Cytokines in Patients with Mood Disorders
    Ghanshyam N Pandey; Fiscal Year: 2013
    ..Specific Aim 6. We will examine the relationship of the proposed markers to dexamethasone suppression test (DST)...
  15. Lipid storage and mobilization in M. tuberculosis as antilatency drugs targets
    ..will be tested for their ability to successfully go through dormancy and reactivation in a rabbit containment/dexamethasone reactivation model of TB latency...
  16. Elucidating the role of microRNAs in the initiation of multiple myeloma
    Jianjun Zhao; Fiscal Year: 2013
    ..Based on our preliminary data, over- expression of miR-222-221 targets PUMA leads to dexamethasone resistance and CSC accumulation in MM...
  17. Corticosteroids for Children with Febrile Urinary Tract Infections
    Nader Shaikh; Fiscal Year: 2013
    ..multi- center trial in 390 children 3 months to 6 years of age, to determine the efficacy of antibiotics plus dexamethasone therapy, compared with antibiotics alone, on the incidence of renal scarring 6 months after a first febrile ..
    Per Olof J Hasselgren; Fiscal Year: 2010
    ..Studies are performed in two models of muscle wasting, i.e., in septic rats and in dexamethasone-treated cultured myotubes...
  19. The mTORCI-miR-29-AT2R axis in cardiovascular diseases
    Lakshmidevi Pulakat; Fiscal Year: 2013
    ..involves extensive use of anti-inflammatory drugs such as rapamycin (Rap) to prevent vascular restenosis and dexamethasone (Dexa) to manage inflammation...
  20. Investigating the Role of Adipocytes on Leukemia Relapse
    STEVEN DAVID MITTELMAN; Fiscal Year: 2013
    ..effects to impair chemotherapy of ALL: they secrete as yet unidentified factors which cause ALL resistance to dexamethasone, and they concentrate vincristine out of the extracellular environment, making it inaccessible to the ALL ..
  21. Early experience and emotional development in free-ranging primates
    Karen J Parker; Fiscal Year: 2013 response to psychosocial stress (social separations) and pharmacological challenges (CRF challenge, dexamethasone suppression test, metyrapone test, ACTH challenge);and c) assessment of stress-induced CSF concentrations of ..
  22. Role of ER Stress in the Pathogenesis of Primary Open Angle Glaucoma
    GULAB ZODE; Fiscal Year: 2013
    ..will examine whether induction of ER stress in the TM is associated with elevation of IOP in a mouse model of dexamethasone-induced ocular hypertension...
  23. Prevalence and Correlates of Minor Depression in Type 2 Diabetes
    Sherita Hill Golden; Fiscal Year: 2012
    ..and problem-solving ability) in all participants and will assess subclinical hypercortisolism, using a dexamethasone suppression test, in all 100 subjects who screen positive on the PHQ-2 and in 50 random controls who screen ..
  24. HPA Stress Reactivity &Genetic Influences in Postpartum Depression
    ..In Aim 1, we will compare HPA axis stress reactivity using both physiological (dexamethasone/CRH) and psychological (Trier Social Stress Test) challenges in euthymic women with a history of PPD, women ..
  25. Treatment of glucocorticoid-induced osteonecrosis with nano-fullerenes
    Quanjun Cui; Fiscal Year: 2013
    ..To determine the antagonizing activity of nano-fullerenes against dexamethasone (DEX)- induced adipogenesis and apoptosis in rabbit bone marrow stromal cells in vitro. 2...
  26. Stress Hormones and Chondrogenic Vascular Calcification
    JODI FRANCES EVANS; Fiscal Year: 2013
    ..The data providing evidence of locally produced and processed POMC derived peptides and the regulation by dexamethasone also, opens a new avenue of research;one that encompasses the interactions between leukocytes and mesenchymal ..
  27. Understanding Severe Asthma Using an Experimental Model
    Prabir Ray; Fiscal Year: 2013
    ..Administration of the CS, dexamethasone (Dex), in HDM+c-di-GMP-exposed mice did not subdue the IFN-?/IL-17/IL-13 response or the airway neutrophilia ..
  28. Radiovirotherapy for Multiple Myeloma
    Stephen J Russell; Fiscal Year: 2012
    ..Aim 2. To determine whether dexamethasone can ameliorate the bone marrow toxicity of I-131...
  29. NHE3 Polymorphisms and Chronic Diarrheal Diseases
    Xinjun Zhu; Fiscal Year: 2013
    ..NHE3 function and trafficking in R799C;4) demonstrated that R474Q and R799C mutants failed to respond to acute dexamethasone stimulation, suggesting a possible defect of NHE3 in response to stimulation postprandially;and 5) identified ..
  30. Early Life Stress and Corticosterone Signaling: Relation to Ethanol Drinking
    TRACY RENEE BUTLER; Fiscal Year: 2013
    ..a variety of measurements to comprehensively assess HPA axis function in a within-subject manner, including a dexamethasone suppression test (DST), assessment of plasma CORT following an acute stressor, the effect of pharmacological ..
  31. Requirement for Glucocorticoids for Adipogenesis in vivo.
    Charles A Harris; Fiscal Year: 2012
    ..come from 30 years of analysis of 3T3-L1 cells differentiating in vitro when given an adipogenic cocktail of dexamethasone (glucocorticoid), IBMX (raises intracellular cAMP levels) and insulin...
  32. Effect of Prenatal Programming on Renal Tubular Transport
    Michel G Baum; Fiscal Year: 2012
    ..In preliminary data we have found that administration of dexamethasone to pregnant rats at specific times during fetal development results in hypertension when the animals were ..
  33. Modulating and Monitoring the Foreign Body Response to Implants
    Julie A Stenken; Fiscal Year: 2013 this study to direct macrophage polarization include interleukin-10 (IL-10), an anti-inflammatory cytokine; dexamethasone, an anti-inflammatory corticosteroid;iloprost (PGI2), a promising anti-fibrotic agent;and PGE2, an endogenous ..
  34. MYCN Function in Neuroblastoma
    Naohiko Ikegaki; Fiscal Year: 2012
    ..the "Age Factor" of NB: the younger the patients, the better the outcome, and (Aim 4) examine the efficacy of dexamethasone, a site-specific DNA demethylation inducer in combination with DNA methylation inhibitors (5-Aza-2'- ..
  35. The role of miRNA15a and 16-1 in Multiple Myeloma
    Irene M Ghobrial; Fiscal Year: 2013
    ..of miR15a/16-1 in regulating sensitivity/resistance of MM cells to therapeutic agents such as bortezomib and dexamethasone. These studies will lead to the application of miR-15a/-16-1 as prognostic markers clinically used in practice...
  36. Efficacy of Dexamethasone in Polycystic Ovary Syndrome Related Infertility
    Randal Robinson; Fiscal Year: 2013
    ..However, the addition of dexamethasone (DEX) to CC shows promise as a safe, effective. Inexpensive intervention in this population...
  37. Anti-inflammatory and Mitotic Properties of Non-hormonal Steroids in Lung Epithel
    ERICA REEVES; Fiscal Year: 2010
    ..g. prednisone). We present preliminary data showing that Dexamethasone resynchronizes the cell cycle of asthmatic primary differentiated bronchial epithelial cells and dramatically ..
  38. Determining Optimum Medical Therapy for ITP
    JAMES BRUCE BUSSEL; Fiscal Year: 2013
    ..Prednisone leads to lasting effects in very few patients following a second course;high dose dexamethasone (dex), touted in single arm studies to have curative effects, had lasting effects in only 17% of patients in a ..
  39. Immunization against Atherosclerosis
    Guoxing Zheng; Fiscal Year: 2012
    ..we showed that immunization with peptide antigen, when performed under the influence of the immunosuppressant dexamethasone (DEX) serving as tolerogenic adjuvant (a strategy we termed "suppressed immunization"), caused long-term ..
  40. Encapsulated Active Vitamin D Vaccine for the Treatment of Multiple Sclerosis
    Kristy M Ainslie; Fiscal Year: 2012
    ..We present preliminary data that shows encapsulation of dexamethasone and MBP peptide results in increased formation of MBP specific iT-regs in the CNS and reduced disease ..
  41. Structure and Functions of Steroid Hormone Receptors
    H Eric Xu; Fiscal Year: 2010
    ..Until recently, only structures of the isolated DBD or the isolated GR LBD with a single agonist (dexamethasone) had been solved...
  42. Control of Trabecular Meshwork Cytoskeleton
    Donna M Peters; Fiscal Year: 2011
    ..Our studies have shown that dexamethasone activates this pathway during the formation of CLANs...
  43. Peroxiredoxin 6 as an Anti-oxidant Enzyme
    Aron B Fisher; Fiscal Year: 2013
    ..Specific Aim 2 will study induction of Prdx6 by combined KGF and dexamethasone treatment, which our preliminary data indicate have a synergistic effect on Prdx6 expression...
  44. Ancillary Studies in Clinical Trials - PRIMeR
    Marcelo C Pasquini; Fiscal Year: 2013
    ..only, 3) 4 cycles of chemotherapy including lenalidomide (Revlimid(r)), bortezomib (Velcade(r)), and dexamethasone (RVD) followed by 3 years of lenalidomide maintenance. This trial will enroll 750 patients from about 50 U.S...
  45. Tr1-Specific Tolerance: a Novel Treatment of Multiple Sclerosis
    Kanneganti Murthy; Fiscal Year: 2012 a negative (sham) control group not exposed to PLP139-151, and a positive control group treated with dexamethasone. Animals will be monitored for overt neurological deterioration over a period of 1 month...
  46. Ocular Drug Delivery Devices for Improved Postoperative Cataract Care
    Buddy D Ratner; Fiscal Year: 2010
    ..One bead-shaped device will integrate dexamethasone for the prevention of inflammation...
  47. Pharmacology of Rescue from Acoustic Trauma
    William F Sewell; Fiscal Year: 2013
    ..g. dexamethasone). Rescue from acoustic trauma is most effective when triggered days after the injury...
  48. Mechanisms of Virus-Induced Hyperreactivity in Atopics
    David B Jacoby; Fiscal Year: 2010
    ..these with interferon? (produced in response to viral infections) will be studied, as well as the effects of dexamethasone treatment...
  49. The Role of DEK in the Development of Arthritis
    Nirit Mor Vaknin; Fiscal Year: 2011
    ..In addition, dexamethasone and cyclosporin, two powerful anti-inflammatory medications used to treat autoimmune diseases, can block DEK ..
    ..TM Habermann) and thalidomide in multiple myeloma (E1A04 Dr. SV Rajkumar). The thrombotic risks of high-dose dexamethasone changed the practice in myeloma (E4A03 Dr SV Rajkumar). In leukemia, Dr...
  51. Targeting surface b2M for myeloma and bone therapy
    Qing Yi; Fiscal Year: 2013
    ..g., dexamethasone)...
  52. Chemoradiotherapy for Multiple Myeloma
    Apollina Goel; Fiscal Year: 2012
    ..In Aim 1 we will evaluate the ability of combined dexamethasone treatment and 153-Sm-EDTMP radiotherapy to selectively enhance the therapeutic index for MM by inhibiting IL6 ..
  53. Biomarkers of Psychological Risk and Resilience in World Trade Center Responders
    STEVEN M M SOUTHWICK; Fiscal Year: 2013
    ..cortisol and adrenocorticotropin hormone (ACTH) levels in blood before and after administration of a steroid, dexamethasone (dexamethasone suppression test);(3) measurement of the inhibition of lysozyme synthesis in blood cells by ..
  54. MR: GR Balance in Depression
    Juan F Lopez; Fiscal Year: 2012
    ..Most work in depression has focused on GR with the traditional dexamethasone suppression test (DST). But, there are a number of reasons to expect that MR may be relevant for depression...
  55. Targeting MUC4 for chemosensitization of pancreatic cancer
    Surinder K Batra; Fiscal Year: 2013
    ..In aim 2 we will examine the effect of FP treatment on PC cell function in vitro, compare FP with dexamethasone (a glucocorticoid currently used in co-treatment with cancer chemotherapy) in affecting the sensitivity of PC ..
  56. Concept of bone "citration": an essential function of differentiated osteoblasts
    Leslie C Costello; Fiscal Year: 2013
    ..g. the requirements for vitamin D vs. dexamethasone. The study will show for the first time that osteoblasts are specialized zinc-accumulating citrate-producing ..
  57. Biomarkers of aging in a free-ranging primate population
    Dario Maestripieri; Fiscal Year: 2009
    ..Plasma cortisol responses to a dexamethasone suppression test will be used to assess glucocorticoid negative feedback...
  58. Porous Silicon Particles for Sustained Intravitreal Drug Delivery
    Lingyun Cheng; Fiscal Year: 2013
    ..Three candidate drugs: bevacizumab, daunorubicin, and dexamethasone, will be used as model drugs to investigate this novel and unique system...
  59. The Role of DEK in the Development of Arthritis
    Nirit Mor-Vaknin; Fiscal Year: 2013
    ..In addition, dexamethasone and cyclosporin, two powerful anti-inflammatory medications used to treat autoimmune diseases, can block DEK ..
  60. Chaetocin as a Potential Therapy for Multiple Myeloma
    Keith C Bible; Fiscal Year: 2012
    ..Impressively, the anti-myeloma effects of chaetocin are maintained in dexamethasone- or doxorubicin-resistant myeloma cells and in patient myeloma samples collected from heavily pre-treated ..
  61. Development of a new Imaging Platform for Pharmaceutical and Biomedical applicati
    Lynne S Taylor; Fiscal Year: 2012
    ..Model drugs will include itraconazole and griseofulvin (combined with oral delivery polymers), dexamethasone and naltrexone (combined with biodegradable polymers), and sirolimus and paclitaxel (combined with device ..
  62. Novel Therapies for Resistant FSGS
    Howard Trachtman; Fiscal Year: 2011 compare the efficacy of cyclosporine, the current standard of care, with a combination of MMF and oral dexamethasone pulses in patients with steroid-resistant FSGS...
    Hasan Mukhtar; Fiscal Year: 1999
    ..of apoptosis, then by attempting to block apoptosis by basic fibroblast growth factor or enhance it by dexamethasone, with assessment of apoptosis by DNA fragmentation, histology, direct immunoperoxidase staining of digoxigenin-..
    Robert Van Buskirk; Fiscal Year: 1990
    ..Furthermore, work presented in this proposal (1) demonstrates that dexamethasone completely inhibits this nerve growth factor-induced increase in casein kinase activity and that (2) this ..
    Jill Buyon; Fiscal Year: 2004
    ..In Specific Aim 1, a randomized double-blind placebo-controlled trial will examine the effect of daily oral dexamethasone (4 mg) on the outcome of CHB...
    Dennis Trune; Fiscal Year: 2000
    In spite of years of treating various forms of hearing loss with glucocorticoids (prednisone, dexamethasone), there is virtually no clinical or experimental evidence that inflammation of the ear is the underlying etiology...
    Linda Brady; Fiscal Year: 1993
    ..In H4IIE cells and hepatocytes CPT mRNA is induced by peroxisomal proliferators, cAMP, dexamethasone, epinephrine, fatty acids and dicarboxylic acids, and repressed by insulin...
    RENA D SOUZA; Fiscal Year: 2001
    ..Our studies of adult denition in TGF-beta1 (-/-) mice kept alive on dexamethasone show extensive pulp and periapical pathology and a marked attrition of occlusal surfaces...
  69. Prophylaxis of adrenal insufficiency to prevent CLD
    Kristi Watterberg; Fiscal Year: 2005
    ..Early treatment with dexamethasone may decrease CLD; however, this therapy has serious immediate and long-term adverse effects...
    Candace Johnson; Fiscal Year: 2009
    ..In vitro and in vivo, dexamethasone (dex) potentiates calcitriol-mediated antitumor activity through the vitamin D receptor (VDR)...
  71. Development of a novel anti-inflammatory treatment for clinical management of end
    Rafal Farjo; Fiscal Year: 2009
    ..To address inflammation, the administration of a steroid, such as dexamethasone, is often given concurrently with antibiotics;however, multiple studies have demonstrated that dexamethasone ..
  72. Evaluation of CYP24 as a Target for Enhancing Vitamin D*
    Donald Trump; Fiscal Year: 2006
    ..g. taxanes, platinum analogues, antracenediones). High dose dexamethasone (Dex) potentiates the antitumor effects and blunts calcitriol-induced hypercalcemia...
    Evan Simpson; Fiscal Year: 2005
    ..promoter selection appears to be dictated by the culture conditions, namely the presence or absence of cAMP, dexamethasone and growth factors...