dexamethasone

Summary

Summary: An anti-inflammatory 9-fluoro-glucocorticoid.

Top Publications

  1. pmc Genomic determination of the glucocorticoid response reveals unexpected mechanisms of gene regulation
    Timothy E Reddy
    HudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA
    Genome Res 19:2163-71. 2009
  2. pmc A factorial trial of six interventions for the prevention of postoperative nausea and vomiting
    Christian C Apfel
    Julius Maximilians Universitat, Wurzburg, Germany
    N Engl J Med 350:2441-51. 2004
  3. pmc Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: an open-label randomised controlled trial
    S Vincent Rajkumar
    Mayo Clinic, Rochester, Minnesota, USA
    Lancet Oncol 11:29-37. 2010
  4. ncbi Randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with macular edema due to retinal vein occlusion
    Julia A Haller
    Wills Eye Institute, Philadelphia, Pennsylvania 19107, USA
    Ophthalmology 117:1134-1146.e3. 2010
  5. ncbi Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo
    Min H Kang
    Developmental Therapeutics Program, Childrens Hospital Los Angeles and University of Southern California Institute for Pediatric Clinical Research, Los Angeles, CA 90027, USA
    Blood 110:2057-66. 2007
  6. pmc Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma
    Paul G Richardson
    Dana Farber Cancer Institute, Boston, MA 02115, USA
    Blood 116:679-86. 2010
  7. doi Bortezomib plus dexamethasone is superior to vincristine plus doxorubicin plus dexamethasone as induction treatment prior to autologous stem-cell transplantation in newly diagnosed multiple myeloma: results of the IFM 2005-01 phase III trial
    Jean Luc Harousseau
    Centre Rene Gauducheau, Nantes St Herblain, France
    J Clin Oncol 28:4621-9. 2010
  8. ncbi Dexamethasone intravitreal implant for treatment of diabetic macular edema in vitrectomized patients
    David S Boyer
    Retina Vitreous Associates Medical Group, Los Angeles, California, USA
    Retina 31:915-23. 2011
  9. pmc Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor
    Mauro Perretti
    1 Department of Biochemical Pharmacology, William Harvey Research Institute, Bart s and the London School of Medicine, Queen Mary University of London, Charterhouse Square, London, UK 2 M P and N C contributed equally to this paper
    Nat Med 8:1296-302. 2002
  10. ncbi The E3 Ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle
    Brian A Clarke
    Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, MA 02139, USA
    Cell Metab 6:376-85. 2007

Detail Information

Publications345 found, 100 shown here

  1. pmc Genomic determination of the glucocorticoid response reveals unexpected mechanisms of gene regulation
    Timothy E Reddy
    HudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA
    Genome Res 19:2163-71. 2009
    ..and measured related changes in gene expression with mRNA sequencing in response to the glucocorticoid dexamethasone (DEX)...
  2. pmc A factorial trial of six interventions for the prevention of postoperative nausea and vomiting
    Christian C Apfel
    Julius Maximilians Universitat, Wurzburg, Germany
    N Engl J Med 350:2441-51. 2004
    ..Although many trials have been conducted, the relative benefits of prophylactic antiemetic interventions given alone or in combination remain unknown...
  3. pmc Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: an open-label randomised controlled trial
    S Vincent Rajkumar
    Mayo Clinic, Rochester, Minnesota, USA
    Lancet Oncol 11:29-37. 2010
    High-dose dexamethasone is a mainstay of therapy for multiple myeloma. We studied whether low-dose dexamethasone in combination with lenalidomide is non-inferior to and has lower toxicity than high-dose dexamethasone plus lenalidomide.
  4. ncbi Randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with macular edema due to retinal vein occlusion
    Julia A Haller
    Wills Eye Institute, Philadelphia, Pennsylvania 19107, USA
    Ophthalmology 117:1134-1146.e3. 2010
    To evaluate the safety and efficacy of dexamethasone intravitreal implant (DEX implant; OZURDEX, Allergan, Inc...
  5. ncbi Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo
    Min H Kang
    Developmental Therapeutics Program, Childrens Hospital Los Angeles and University of Southern California Institute for Pediatric Clinical Research, Los Angeles, CA 90027, USA
    Blood 110:2057-66. 2007
    ..We evaluated the cytotoxicity of ABT-737 in combination with vincristine, dexamethasone, and L-asparaginase (VXL) in 7 ALL cell lines...
  6. pmc Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma
    Paul G Richardson
    Dana Farber Cancer Institute, Boston, MA 02115, USA
    Blood 116:679-86. 2010
    This phase 1/2 study is the first prospective evaluation of lenalidomide-bortezomib-dexamethasone in front-line myeloma. Patients (N = 66) received 3-week cycles (n = 8) of bortezomib 1.0 or 1...
  7. doi Bortezomib plus dexamethasone is superior to vincristine plus doxorubicin plus dexamethasone as induction treatment prior to autologous stem-cell transplantation in newly diagnosed multiple myeloma: results of the IFM 2005-01 phase III trial
    Jean Luc Harousseau
    Centre Rene Gauducheau, Nantes St Herblain, France
    J Clin Oncol 28:4621-9. 2010
    To compare efficacy and safety of bortezomib plus dexamethasone and vincristine plus doxorubicin plus dexamethasone (VAD) as induction before stem-cell transplantation in previously untreated myeloma.
  8. ncbi Dexamethasone intravitreal implant for treatment of diabetic macular edema in vitrectomized patients
    David S Boyer
    Retina Vitreous Associates Medical Group, Los Angeles, California, USA
    Retina 31:915-23. 2011
    To evaluate the safety and efficacy of Ozurdex (dexamethasone intravitreal implant) 0.7 mg in the treatment of diabetic macular edema in vitrectomized eyes.
  9. pmc Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor
    Mauro Perretti
    1 Department of Biochemical Pharmacology, William Harvey Research Institute, Bart s and the London School of Medicine, Queen Mary University of London, Charterhouse Square, London, UK 2 M P and N C contributed equally to this paper
    Nat Med 8:1296-302. 2002
    Aspirin (ASA) and dexamethasone (DEX) are widely used anti-inflammatory agents yet their mechanism(s) for blocking polymorphonuclear neutrophil (PMN) accumulation at sites of inflammation remains unclear...
  10. ncbi The E3 Ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle
    Brian A Clarke
    Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, MA 02139, USA
    Cell Metab 6:376-85. 2007
    Skeletal muscle atrophy occurs as a side effect of treatment with synthetic glucocorticoids such as dexamethasone (DEX) and is a hallmark of cachectic syndromes associated with increased cortisol levels...
  11. doi Induction of Treg by monocyte-derived DC modulated by vitamin D3 or dexamethasone: differential role for PD-L1
    Wendy W J Unger
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 39:3147-59. 2009
    ..In this study we compared the tolerizing capacity of dexamethasone (Dex)- and 1 alpha,25-dihydroxyvitamin D3 (VD3)-modulated DC...
  12. ncbi Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults
    Guy E Thwaites
    Oxford University Clinical Research Unit at the Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    N Engl J Med 351:1741-51. 2004
    ....
  13. doi A randomized phase 3 study on the effect of thalidomide combined with adriamycin, dexamethasone, and high-dose melphalan, followed by thalidomide maintenance in patients with multiple myeloma
    Henk M Lokhorst
    University Medical Center, Utrecht, The Netherlands
    Blood 115:1113-20. 2010
    ..A total of 556 patients was randomly assigned to arm A: 3 cycles of vincristine, adriamycin, and dexamethasone, or to arm B: thalidomide 200 mg orally, days 1 to 28 plus adriamycin and dexamethasone...
  14. doi Bortezomib with thalidomide plus dexamethasone compared with thalidomide plus dexamethasone as induction therapy before, and consolidation therapy after, double autologous stem-cell transplantation in newly diagnosed multiple myeloma: a randomised phase 3
    Michele Cavo
    Istituto di Ematologia Seragnoli, Universita degli Studi di Bologna, Bologna, Italy
    Lancet 376:2075-85. 2010
    Thalidomide plus dexamethasone (TD) is a standard induction therapy for myeloma...
  15. ncbi Resetting of circadian time in peripheral tissues by glucocorticoid signaling
    A Balsalobre
    , Sciences II, , 30 Quai Ernest Ansermet, , Switzerland
    Science 289:2344-7. 2000
    ..Here, we show that the glucocorticoid hormone analog dexamethasone induces circadian gene expression in cultured rat-1 fibroblasts and transiently changes the phase of circadian ..
  16. ncbi Phagocytosis and clearance of apoptotic cells is mediated by MER
    R S Scott
    UNC Neuroscience Center, USA
    Nature 411:207-11. 2001
    ..Thus, the Mer receptor tyrosine kinase seems to be critical for the engulfment and efficient clearance of apoptotic cells. This has implications for inflammation and autoimmune diseases such as systemic lupus erythematosus...
  17. ncbi Modulation of phagocytosis of apoptotic neutrophils by supernatant from dexamethasone-treated macrophages and annexin-derived peptide Ac(2-26)
    Paola Maderna
    Department of Medicine and Therapeutics, The Conway Institute of Biomolecular and Biomedical Research, The Dublin Molecular Medicine Centre, University College Dublin, Dublin, Ireland
    J Immunol 174:3727-33. 2005
    ..role of endogenous annexin on clearance of apoptotic cells, Mphi were cultured for 5 days in the presence of dexamethasone. Supernatants collected from dexamethasone-treated Mphi significantly enhanced the ability of naive Mphi to ..
  18. pmc Glucocorticoid sensitivity of lipopolysaccharide-stimulated chronic obstructive pulmonary disease alveolar macrophages
    J Armstrong
    University of Manchester, NIHR Translational Research Facility, University Hospital of South Manchester Foundation Trust, Manchester, UK
    Clin Exp Immunol 158:74-83. 2009
    ..15 COPD patients, nine smokers (S) and nine healthy non-smokers (HNS) were stimulated with LPS with or without dexamethasone (100 and 1000 nM)...
  19. doi Bortezomib plus dexamethasone induction improves outcome of patients with t(4;14) myeloma but not outcome of patients with del(17p)
    Herve Avet-Loiseau
    Centre Hospitalier Universitaire, Nantes, France
    J Clin Oncol 28:4630-4. 2010
    ..Patients presenting with either t(4;14) or del(17p) are known to have a short event-free survival (EFS) and overall survival (OS). Some preliminary data suggest that bortezomib is able to overcome these prognostic parameters...
  20. doi Dexamethasone intravitreal implant in patients with macular edema related to branch or central retinal vein occlusion twelve-month study results
    Julia A Haller
    Wills Eye Institute, Philadelphia, Pennsylvania 19107, USA
    Ophthalmology 118:2453-60. 2011
    To evaluate the safety and efficacy of 1 or 2 treatments with dexamethasone intravitreal implant (DEX implant) over 12 months in eyes with macular edema owing to branch or central retinal vein occlusion (BRVO or CRVO).
  21. doi Dexamethasone and length of hospital stay in patients with community-acquired pneumonia: a randomised, double-blind, placebo-controlled trial
    Sabine C A Meijvis
    Department of Internal Medicine, St Antonius Hospital, Nieuwegein, Netherlands
    Lancet 377:2023-30. 2011
    ..We aimed to assess effect of addition of dexamethasone on length of stay in this group, which might result in earlier resolution of pneumonia through dampening of ..
  22. pmc Bortezomib, dexamethasone, cyclophosphamide and lenalidomide combination for newly diagnosed multiple myeloma: phase 1 results from the multicenter EVOLUTION study
    S K Kumar
    Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA
    Leukemia 24:1350-6. 2010
    ..conducted to determine the maximum tolerated dose (MTD) of cyclophosphamide in combination with bortezomib, dexamethasone and lenalidomide (VDCR) and to assess the safety and efficacy of this combination in untreated multiple ..
  23. ncbi Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
    C M Pariante
    Section of Clinical Neuropharmacology, Institute of Psychiatry, King's College London, London, United Kingdom
    Biol Psychiatry 49:391-404. 2001
    ..features of this HPA axis hyperactivity is reduced sensitivity to the inhibitory effects of the glucocorticoid dexamethasone on the production of adrenocorticotropic hormone and cortisol during the dexamethasone suppression test and, ..
  24. ncbi Antiemetics: American Society of Clinical Oncology clinical practice guideline update
    Ethan Basch
    Memorial Sloan Kettering Cancer Center, New York, USA
    J Clin Oncol 29:4189-98. 2011
    ..To update the American Society of Clinical Oncology (ASCO) guideline for antiemetics in oncology...
  25. pmc The combined dexamethasone/CRH Test (DEX/CRH test) and prediction of acute treatment response in major depression
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany
    PLoS ONE 4:e4324. 2009
    In this study the predictive value of the combined dexamethasone/CRH test (DEX/CRH test) for acute antidepressant response was investigated.
  26. doi Dexamethasone intravitreal implant for noninfectious intermediate or posterior uveitis
    Careen Lowder
    Cleveland Clinic Cole Eye Institute, 9500 Euclid Ave, i 32, Cleveland, OH 44195, USA
    Arch Ophthalmol 129:545-53. 2011
    To evaluate the safety and efficacy of 2 doses of dexamethasone intravitreal implant (DEX implant) for treatment of noninfectious intermediate or posterior uveitis.
  27. ncbi Randomized controlled clinical trial of a combination of somatostatin analog and dexamethasone plus zoledronate vs. zoledronate in patients with androgen ablation-refractory prostate cancer
    Constantine S Mitsiades
    Department of Experimental Physiology, Medical School, University of Athens, Goudi Athens, Attiki 115 27, Greece
    Anticancer Res 26:3693-700. 2006
    As previously shown, the combination of standard androgen ablation therapy with somatostatin analog and dexamethasone in metastatic androgen ablation-refractory (stage D3) prostate cancer (PrCa) patients has a favorable profile of side-..
  28. ncbi Intergenerational consequences of fetal programming by in utero exposure to glucocorticoids in rats
    Amanda J Drake
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Molecular Medicine Center, Western General Hospital, United Kingdom
    Am J Physiol Regul Integr Comp Physiol 288:R34-8. 2005
    ..We have explored intergenerational effects in the dexamethasone-programmed rat, a model in which fetal exposure to excess glucocorticoid results in low birth weight with ..
  29. ncbi Combined dexamethasone/corticotropin releasing hormone test predicts treatment response in major depression - a potential biomarker?
    Marcus Ising
    Max Planck Institute of Psychiatry, Munich, Germany
    Biol Psychiatry 62:47-54. 2007
    Exaggerated corticotropin (ACTH) and cortisol response to the combined dexamethasone (DEX)/corticotropin releasing hormone (CRH) test, indicating impaired regulation of the hypothalamus-pituitary-adrenocortical (HPA) system, is ..
  30. ncbi Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse
    Robert Hannon
    Department of Biochemical Pharmacology, William Harvey Research Institute, Queen Mary, University of London, Charterhouse Square, EC1M 6BQ, UK
    FASEB J 17:253-5. 2003
    ..There are also gender differences in activated leukocyte behavior in the Anx-1-/- mice that are not seen in the wild-type animals, suggesting an interaction between sex hormones and inflammation in Anx-1-/- animals...
  31. doi Regulation of tristetraprolin expression by interleukin-1 beta and dexamethasone in human pulmonary epithelial cells: roles for nuclear factor-kappa B and p38 mitogen-activated protein kinase
    Elizabeth M King
    Airways Inflammation Group, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Pharmacol Exp Ther 330:575-85. 2009
    ..By contrast, and despite a 3- to 4-fold induction of TTP mRNA, the anti-inflammatory glucocorticoid dexamethasone only modestly induced expression of the approximately 40-kDa form of TTP...
  32. ncbi Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB
    E Ayroldi
    Department of Clinical and Experimental Medicine, Section of Pharmacology, University of Perugia, Via del Giochetto, 06100 Perugia, Italy
    Blood 98:743-53. 2001
    ..was identified that encodes a glucocorticoid-induced leucine zipper (GILZ) whose expression is up-regulated by dexamethasone. This study analyzed the role of GILZ in the control of T-cell activation and its possible interaction with ..
  33. ncbi Glucocorticoid-induced degradation of glycogen synthase kinase-3 protein is triggered by serum- and glucocorticoid-induced protein kinase and Akt signaling and controls beta-catenin dynamics and tight junction formation in mammary epithelial tumor cells
    Kim L Failor
    Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720 3200, USA
    Mol Endocrinol 21:2403-15. 2007
    ..We now demonstrate that treatment with the synthetic glucocorticoid dexamethasone induces the ubiquitin-26S proteasome-mediated degradation of GSK3 protein with no change in GSK3 transcript ..
  34. pmc Cyclophosphamide, thalidomide, and dexamethasone (CTD) as initial therapy for patients with multiple myeloma unsuitable for autologous transplantation
    Gareth J Morgan
    Institute of Cancer Research, Royal Marsden Hospital, London, United Kingdom
    Blood 118:1231-8. 2011
    ..the randomized MRC Myeloma IX trial, we compared an attenuated regimen of cyclophosphamide, thalidomide, and dexamethasone (CTDa; n = 426) with melphalan and prednisolone (MP; n = 423) in patients with newly diagnosed multiple ..
  35. pmc Prenatal dexamethasone programs hypertension and renal injury in the rat
    Luis A Ortiz
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75235 9063, USA
    Hypertension 41:328-34. 2003
    b>Dexamethasone is frequently administered to the developing fetus to accelerate pulmonary development...
  36. doi Perifosine plus bortezomib and dexamethasone in patients with relapsed/refractory multiple myeloma previously treated with bortezomib: results of a multicenter phase I/II trial
    Paul G Richardson
    Dana Farber Cancer Institute, 44 Binney St, Dana 1B02, Boston, MA 02115, USA
    J Clin Oncol 29:4243-9. 2011
    ..Preclinical data show that the novel signal transduction modulator, perifosine, enhances the cytotoxicity of dexamethasone and bortezomib...
  37. pmc Clarithromycin (Biaxin)-lenalidomide-low-dose dexamethasone (BiRd) versus lenalidomide-low-dose dexamethasone (Rd) for newly diagnosed myeloma
    Francesca Gay
    Division of Hematology, Department of Internal Medicine, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Am J Hematol 85:664-9. 2010
    ..was to compare the efficacy and toxicity of the addition of clarithromycin (Biaxin) to lenalidomide/low-dose dexamethasone (BiRd) vs. lenalidomide/low-dose dexamethasone (Rd) for newly diagnosed myeloma...
  38. doi Treatment of patients with relapsed/refractory multiple myeloma with lenalidomide and dexamethasone with or without bortezomib: prospective evaluation of the impact of cytogenetic abnormalities and of previous therapies
    M A Dimopoulos
    Department of Clinical Therapeutics, University of Athens School of Medicine, Athens, Greece
    Leukemia 24:1769-78. 2010
    ..cytogenetic abnormalities (CAs) in patients with relapsed/refractory myeloma who received lenalidomide and dexamethasone (RD) with or without the addition of bortezomib (V)...
  39. doi FHL2 mediates dexamethasone-induced mesenchymal cell differentiation into osteoblasts by activating Wnt/beta-catenin signaling-dependent Runx2 expression
    Zahia Hamidouche
    INSERM U606, Hopital Lariboisiere, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France
    FASEB J 22:3813-22. 2008
    ..of the LIM protein superfamily, that is up-regulated during early osteoblast differentiation induced by dexamethasone in murine and human MSCs...
  40. pmc Inhibition of lipopolysaccharide-stimulated chronic obstructive pulmonary disease macrophage inflammatory gene expression by dexamethasone and the p38 mitogen-activated protein kinase inhibitor N-cyano-N'-(2-{[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylph
    Lauren M Kent
    Education and Research Centre 2nd Floor Office, South Manchester University Hospitals Trust, Wythenshawe Hospital, Southmoor Road, Manchester M23 9LT, UK
    J Pharmacol Exp Ther 328:458-68. 2009
    ..SB706504) and dexamethasone on COPD macrophage inflammatory gene expression and protein secretion...
  41. ncbi Osteoblastogenic effects of dexamethasone through upregulation of TAZ expression in rat mesenchymal stem cells
    Dun Hong
    Institute of Cell Biology, Medical College of Zhejiang University, 388 Yuhangtang Road, Hangzhou 310058, Zhejiang Province, China
    J Steroid Biochem Mol Biol 116:86-92. 2009
    ..b>Dexamethasone (DEX), a synthetic and widely used glucocorticoid, affects osteogenesis...
  42. doi Randomized, multicenter, phase 2 study (EVOLUTION) of combinations of bortezomib, dexamethasone, cyclophosphamide, and lenalidomide in previously untreated multiple myeloma
    Shaji Kumar
    Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA
    Blood 119:4375-82. 2012
    Combinations of bortezomib (V) and dexamethasone (D) with either lenalidomide (R) or cyclophosphamide (C) have shown significant efficacy...
  43. doi Major tumor shrinking and persistent molecular remissions after consolidation with bortezomib, thalidomide, and dexamethasone in patients with autografted myeloma
    Marco Ladetto
    Cattedra di Ematologia, Via Genova 3, 10126 Torino, Italy
    J Clin Oncol 28:2077-84. 2010
    ..polymerase chain reaction (RQ-PCR), of a consolidation regimen that included bortezomib, thalidomide, and dexamethasone (VTD) in patients with multiple myeloma (MM) responding to autologous stem-cell transplantation (auto-SCT)...
  44. ncbi The combined dexamethasone/CRH test as a potential surrogate marker in depression
    Marcus Ising
    Max Planck Institute of Psychiatry, Kraepelinstr 10, D 80804 Munich, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 29:1085-93. 2005
    ..in a dysfunctional stress hormone regulation, which can be most sensitively detected with the combined dexamethasone (dex)/corticotropin releasing hormone (CRH) test...
  45. doi Effects of loteprednol/tobramycin versus dexamethasone/tobramycin on intraocular pressure in healthy volunteers
    Edward J Holland
    Cincinnati Eye Institute and University of Cincinnati, Cincinnati, OH, USA
    Cornea 27:50-5. 2008
    To compare the steroid-induced intraocular pressure (IOP) and other ocular adverse effects of loteprednol etabonate 0.5% and tobramycin 0.3% ophthalmic suspension with those of dexamethasone 0.1% and tobramycin 0.3% ophthalmic suspension.
  46. doi Efficacy of L-asparaginase with methotrexate and dexamethasone (AspaMetDex regimen) in patients with refractory or relapsing extranodal NK/T-cell lymphoma, a phase 2 study
    Arnaud Jaccard
    Service d Hématologie et de Thérapie Cellulaire, Centre Hospitalier Universitaire CHU Limoges, Université et Centre National de la Recherche Scientifique CNRS, Unité Mixte de Recherche UMR 6101, Limoges, France
    Blood 117:1834-9. 2011
    ..First-line L-asparaginase combination therapy for extranodal NK/T-cell lymphoma warrants evaluation in prospective trials. This trial is registered at www.clinicaltrials.gov as #NCT00283985...
  47. ncbi Effects of transforming growth factor beta1 and dexamethasone on the growth and chondrogenic differentiation of adipose-derived stromal cells
    Hani A Awad
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Tissue Eng 9:1301-12. 2003
    ..bovine serum (FBS) and treated with different doses and combinations of TGF-beta1 (0, 1, and 10 ng/mL) and dexamethasone (0, 10, and 100 nM)...
  48. ncbi Adverse neonatal outcomes associated with antenatal dexamethasone versus antenatal betamethasone
    Ben H Lee
    Division of Neonatal Perinatal Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Pediatrics 117:1503-10. 2006
    Antenatal dexamethasone and betamethasone may not be equally efficacious in the prevention of adverse neonatal outcomes...
  49. ncbi Protein kinase B-alpha inhibits human pyruvate dehydrogenase kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors
    Hye Sook Kwon
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Diabetes 53:899-910. 2004
    ..Treatment of HepG2 cells with dexamethasone increases the relative abundance of PDK4 mRNA, and insulin blocks this effect...
  50. ncbi Dexamethasone prevents long-lasting learning impairment following a combination of lipopolysaccharide and hypoxia-ischemia in neonatal rats
    Tomoaki Ikeda
    Department of Obstetrics and Gynecology, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan
    Am J Obstet Gynecol 192:719-26. 2005
    ..We administered dexamethasone (DEX), a synthetic corticosteroid anti-inflammatory drug, to neonatal rats in a model of such damage induced ..
  51. ncbi Effect of dexamethasone on adipocyte differentiation markers and tumour necrosis factor-alpha expression in human PAZ6 cells
    V Zilberfarb
    Institute Cochin of Molecular Genetics, Paris, France
    Diabetologia 44:377-86. 2001
    ..We therefore studied the effect of dexamethasone on TNF-alpha expression and adipocyte differentiation in human PAZ6 cells...
  52. pmc Effect of prenatal dexamethasone on rat renal development
    L A Ortiz
    Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, Texas 75235-9063, USA
    Kidney Int 59:1663-9. 2001
    BACKGROUND: Prenatal insults can program the developing fetus to develop diseases that manifest in later life. Dexamethasone is often administered to the developing fetus to accelerate pulmonary development...
  53. ncbi Lung-targeting delivery of dexamethasone acetate loaded solid lipid nanoparticles
    Qing Yu Xiang
    Key Laboratory of Drug Targeting of Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, P R China
    Arch Pharm Res 30:519-25. 2007
    ..of the present study was to develop a novel solid lipid nanoparticle (SLN) for the lung-targeting delivery of dexamethasone acetate (DXM) by intravenous administration...
  54. doi Chemotherapy-induced nausea and vomiting
    Paul J Hesketh
    Caritas St Elizabeth s Medical Center, Boston, MA 02135, USA
    N Engl J Med 358:2482-94. 2008
  55. ncbi Corticosteroid-induced kidney dysmorphogenesis is associated with deregulated expression of known cystogenic molecules, as well as Indian hedgehog
    Shun Kai Chan
    Nephro Urology, University College London Institute of Child Health, London, United Kingdom
    Am J Physiol Renal Physiol 298:F346-56. 2010
    ..4 or 14 microM) underwent a dose-dependant deceleration of overall growth accompanied by cyst formation. Dexamethasone, a glucocorticoid, reproduced these outcomes, but aldosterone, a mineralocorticoid, did not...
  56. pmc The efficacy and safety of lenalidomide plus dexamethasone in relapsed and/or refractory multiple myeloma patients with impaired renal function
    Meletios Dimopoulos
    Department of Clinical Therapeutics, University of Athens School of Medicine, Alexandra Hospital, Athens, Greece
    Cancer 116:3807-14. 2010
    ..to assess the impact of various degrees of renal dysfunction on safety and efficacy outcomes in a large cohort of patients with relapsed and/or refractory multiple myeloma who received treatment with lenalidomide plus dexamethasone.
  57. pmc GILZ mediates the antiproliferative activity of glucocorticoids by negative regulation of Ras signaling
    Emira Ayroldi
    Department of Clinical and Experimental Medicine, Section of Pharmacology, University of Perugia, Perugia, Italy
    J Clin Invest 117:1605-15. 2007
    Tsc22d3 coding for glucocorticoid-induced leucine zipper (GILZ) was initially identified as a dexamethasone-responsive gene involved in the control of T lymphocyte activation and apoptosis...
  58. pmc BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone
    Jerome Moreaux
    Institut National de la Santé et de la Recherche Médicale U475 and Unité de Thérapie Cellulaire, Centre Hospitalier Universitaire Montpellier, Hopital St Eloi, France
    Blood 103:3148-57. 2004
    ..in the survival of primary myeloma cells cultured with their bone-marrow environment, and protected them from dexamethasone (DEX)-induced apoptosis...
  59. doi Long-term follow-up on overall survival from the MM-009 and MM-010 phase III trials of lenalidomide plus dexamethasone in patients with relapsed or refractory multiple myeloma
    M A Dimopoulos
    Department of Clinical Therapeutics, University of Athens School of Medicine, Athens, Greece
    Leukemia 23:2147-52. 2009
    ..placebo-controlled randomized phase III trials that included 704 patients and assessed lenalidomide plus dexamethasone versus dexamethasone plus placebo in patients with relapsed/refractory multiple myeloma (MM)...
  60. pmc Lenalidomide and high-dose dexamethasone compared with dexamethasone as initial therapy for multiple myeloma: a randomized Southwest Oncology Group trial (S0232)
    Jeffrey A Zonder
    Division of Hematology Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Blood 116:5838-41. 2010
    The Southwest Oncology Group conducted a randomized trial comparing lenalidomide (LEN) plus dexamethasone (DEX; n = 97) to placebo (PLC) plus DEX (n = 95) in newly diagnosed myeloma...
  61. doi Nationwide implementation of adjunctive dexamethasone therapy for pneumococcal meningitis
    M C Brouwer
    Department of Neurology, Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center, Amsterdam, The Netherlands
    Neurology 75:1533-9. 2010
    In this nationwide prospective cohort study, we evaluated the implementation of adjunctive dexamethasone therapy in Dutch adults with pneumococcal meningitis.
  62. ncbi The anti-inflammatory effect of glucocorticoids is mediated by glucocorticoid-induced leucine zipper in epithelial cells
    Jane Eddleston
    Veterans Medical Research Foundation, La Jolla, CA, USA
    J Allergy Clin Immunol 119:115-22. 2007
    ..A recently described anti-inflammatory protein, glucocorticoid-induced leucine zipper (GILZ), interferes with NF-kappaB-mediated gene transcription in T cells and macrophages...
  63. doi Influence of cytogenetics in patients with relapsed or refractory multiple myeloma treated with lenalidomide plus dexamethasone: adverse effect of deletion 17p13
    Donna Reece
    Division of Oncology, Princess Margaret Hospital, Toronto, Ontario, Canada
    Blood 114:522-5. 2009
    Although the combination of lenalidomide and dexamethasone is effective therapy for patients with relapsed/refractory multiple myeloma, the influence of high-risk cytogenetic abnormalities on outcomes is unknown...
  64. ncbi A new dexamethasone-induced gene of the leucine zipper family protects T lymphocytes from TCR/CD3-activated cell death
    F D'Adamio
    Department of Clinical Medicine, Pathology and Pharmacology, University of Perugia, Italy
    Immunity 7:803-12. 1997
    By comparing mRNA species expressed in dexamethasone (DEX)-treated and untreated murine thymocytes, we have identified a gene, glucocorticoid-induced leucine zipper (GILZ), encoding a new member of the leucine zipper family...
  65. ncbi Cortisol and ACTH response to oral dexamethasone in obesity and effects of sex, body fat distribution, and dexamethasone concentrations: a dose-response study
    Renato Pasquali
    Department of Internal Medicine, Endocrinology Unit, University of Bologna, I 40100 Bologna, Italy
    J Clin Endocrinol Metab 87:166-75. 2002
    ..Our hypothesis is that the lack of adequate cortisol suppression after the dexamethasone test may constitute an indirect marker of HPA axis hyperactivity in the presence of the abdominal obesity ..
  66. doi Randomized controlled trial of an intravitreous dexamethasone drug delivery system in patients with diabetic macular edema
    Julia A Haller
    Wills Eye Institute, 840 Walnut St, Ste 1510, Philadelphia, PA 19107, USA
    Arch Ophthalmol 128:289-96. 2010
    To evaluate the safety and efficacy of a dexamethasone intravitreous drug delivery system (DDS) in eyes with diabetic macular edema (DME).
  67. doi Differential protein pathways in 1,25-dihydroxyvitamin d(3) and dexamethasone modulated tolerogenic human dendritic cells
    Gabriela Bomfim Ferreira
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, University Hospital Gasthuisberg, Catholic University of Leuven, Herestraat 49, BOX 902, B 3000 Leuven, Belgium
    J Proteome Res 11:941-71. 2012
    ..the protein profile, function and phenotype of DCs obtained in vitro in the presence of 1,25(OH)(2)D(3), dexamethasone (DEX), and a combination of both compounds (combi)...
  68. doi Dexamethasone pre-treatment protects brain against hypoxic-ischemic injury partially through up-regulation of vascular endothelial growth factor A in neonatal rats
    Y Feng
    Division of Newborn Medicine, Department of Pediatrics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Neuroscience 179:223-32. 2011
    b>Dexamethasone (Dex) provides neuroprotection against subsequent hypoxia ischemia (HI) in newborn rats, but the mechanism of this neuroprotection is not well understood...
  69. pmc Pomalidomide plus low-dose dexamethasone in myeloma refractory to both bortezomib and lenalidomide: comparison of 2 dosing strategies in dual-refractory disease
    Martha Q Lacy
    Mayo Clinic College of Medicine, Rochester, MN, USA
    Blood 118:2970-5. 2011
    ..We opened 2 sequential phase 2 trials using the pomalidomide with weekly dexamethasone (Pom/dex) regimen at differing doses to study the efficacy of this regimen in patients who have failed both ..
  70. ncbi Outcomes at school age after postnatal dexamethasone therapy for lung disease of prematurity
    Tsu F Yeh
    Department of Pediatrics, College of Medicine, China Medical University, Taichung, Taiwan
    N Engl J Med 350:1304-13. 2004
    ..at school age in children who had participated in a double-blind, placebo-controlled trial of early postnatal dexamethasone therapy (initiated within 12 hours after birth) for the prevention of chronic lung disease of prematurity.
  71. doi Mechanism of glucocorticoid-induced oxidative stress in rat hippocampal slice cultures
    Jung Man You
    Department of Medical Science, Graduate School of East West Medical Science, East West Integrated Medical Science Research Center, Kyung Hee University, Yongin si 446 701, Korea
    Can J Physiol Pharmacol 87:440-7. 2009
    ..for ROS, using 2',7'-dichlorodihydrofluorescein diacetate fluorescence, showed that treatment of synthetic GC, dexamethasone (DEX) significantly enhanced ROS levels...
  72. pmc 11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle
    Stuart A Morgan
    Centre for Endocrinology, Diabetes and Metabolism, Institute of Biomedical Research, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, U K
    Diabetes 58:2506-15. 2009
    ..We aimed to determine the mechanisms underpinning glucocorticoid-induced insulin resistance in skeletal muscle and indentify how 11beta-HSD1 inhibitors improve insulin sensitivity...
  73. doi Epinephrine and dexamethasone in children with bronchiolitis
    Amy C Plint
    Department of Pediatrics, University of Ottawa and Children s Hospital of Eastern Ontario, Ottawa, Canada
    N Engl J Med 360:2079-89. 2009
    ..Although numerous studies have explored the benefit of using nebulized epinephrine or corticosteroids alone to treat infants with bronchiolitis, the effectiveness of combining these medications is not well established...
  74. pmc Prenatal programming of rat thick ascending limb chloride transport by low-protein diet and dexamethasone
    Amit Dagan
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Am J Physiol Regul Integr Comp Physiol 297:R93-9. 2009
    Prenatal administration of dexamethasone and a low-protein diet has been shown to result in hypertension in the offspring when they are adults. The cause for the hypertension is unknown...
  75. doi Dexamethasone with bupivacaine increases duration of analgesia in ultrasound-guided interscalene brachial plexus blockade
    Peter A Vieira
    Department of Anesthesiology, Baystate Medical Center, Springfield, Massachusetts 01199, USA
    Eur J Anaesthesiol 27:285-8. 2010
    b>Dexamethasone has been shown to prolong the duration of postoperative analgesia when given as an adjunct for peripheral nerve blocks...
  76. ncbi A randomized double-blind study comparing rizatriptan, dexamethasone, and the combination of both in the acute treatment of menstrually related migraine
    Marcelo Bigal
    Merck Research Laboratories, Whitehouse Station, NJ, USA
    Headache 48:1286-93. 2008
    To assess the efficacy and tolerability of rizatriptan (RI), dexamethasone (DE), and RI combined with DE (RI+DE) in the acute treatment of menstrually related migraine (MRM).
  77. pmc The role of MAP kinase phosphatase-1 in the protective mechanism of dexamethasone against endotoxemia
    Xianxi Wang
    Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, Ohio, USA
    Life Sci 83:671-80. 2008
    ..The specific aim of the present study is to understand the role of Mkp-1 in the anti-inflammatory function of glucocorticoids...
  78. doi Adiponectin, skeletal muscle adiponectin receptor expression and insulin resistance following dexamethasone
    Christina Jang
    Department of Endocrinology and Diabetes, St Vincent s Hospital, Melbourne, Australia
    Clin Endocrinol (Oxf) 69:745-50. 2008
    ..Skeletal muscle is a major site of adiponectin action and of glucocorticoid-induced insulin resistance. Little human data exist however, regarding the impact of exogenous glucocorticoids on adiponectin receptors in skeletal muscle...
  79. ncbi High-dose melphalan versus melphalan plus dexamethasone for AL amyloidosis
    Arnaud Jaccard
    Department of Hematology, Centre Hospitalier Universitaire, Université et Centre National de la Recherche Scientifique, UMR 6101, Limoges, France
    N Engl J Med 357:1083-93. 2007
    ....
  80. pmc Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1
    O Kassel
    Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, PO Box 3640, D-76021 Karlsruhe, Germany
    EMBO J 20:7108-16. 2001
    ..These results identify MKP-1 as essential for glucocorticoid-mediated control of Erk-1/2 activation and unravel a novel regulatory mechanism for this anti-inflammatory drug...
  81. pmc Prenatal programming of rat proximal tubule Na+/H+ exchanger by dexamethasone
    Amit Dagan
    Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9063, USA
    Am J Physiol Regul Integr Comp Physiol 292:R1230-5. 2007
    Prenatal administration of dexamethasone causes hypertension in rats when they are studied as adults...
  82. ncbi A randomized, double-blind, parallel, comparative study to evaluate the efficacy and safety of ramosetron plus dexamethasone injection for the prevention of acute chemotherapy-induced nausea and vomiting
    Ching Liang Ho
    Division of Hematology Oncology, Tri Service General Hospital, Taipei, Taiwan
    Jpn J Clin Oncol 40:294-301. 2010
    To evaluate the efficacy of intravenous ramosetron plus dexamethasone for the prevention of acute chemotherapy-induced nausea and vomiting.
  83. doi Glucocorticoid receptor activates poised FKBP51 locus through long-distance interactions
    Ville Paakinaho
    Institute of Biomedicine Medical Biochemistry, University of Kuopio, P O Box 1627, FI 70211 Kuopio, Finland
    Mol Endocrinol 24:511-25. 2010
    ..receptor (GR) in human A549 lung cancer cells showing robust accumulation of FKBP51 mRNA in response to dexamethasone exposure...
  84. doi Therapeutic effect of tolerogenic dendritic cells in established collagen-induced arthritis is associated with a reduction in Th17 responses
    Jeroen N Stoop
    Newcastle University, Newcastle upon Tyne, UK
    Arthritis Rheum 62:3656-65. 2010
    ..The aims of this study were to determine the therapeutic action of tolerogenic DCs in a type II collagen-induced arthritis model and to investigate their effects on Th17 cells and other T cell subsets in mice with established arthritis...
  85. pmc Mechanism of glucocorticoid protection of airway smooth muscle from proasthmatic effects of long-acting beta2-adrenoceptor agonist exposure
    Gustavo Nino
    Children s Hospital of Philadelphia Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Allergy Clin Immunol 125:1020-7. 2010
    ..with inhaled glucocorticoids, however, asthma control is improved, raising the following question: Do glucocorticoids inhibit the proasthmatic mechanism that mediates altered contractility in LABA-exposed airway smooth muscle (ASM)?..
  86. pmc Mapracorat, a novel selective glucocorticoid receptor agonist, inhibits hyperosmolar-induced cytokine release and MAPK pathways in human corneal epithelial cells
    Megan E Cavet
    Pharmaceutical R and D, Bausch and Lomb, Inc, Rochester, NY 14609, USA
    Mol Vis 16:1791-800. 2010
    ..This study assessed the anti-inflammatory effects of mapracorat in an in vitro osmotic stress model which mimics some of the pathophysiological changes seen in dry eye...
  87. doi L-plastin phosphorylation: a novel target for the immunosuppressive drug dexamethasone in primary human T cells
    Guido H Wabnitz
    Institute for Immunology, Ruprecht Karls University, Heidelberg, Germany
    Eur J Immunol 41:3157-69. 2011
    ..Interestingly, L-plastin phosphorylation is inhibited by the glucocorticoid dexamethasone. In line with this finding, dexamethasone treatment leads to a reduced F-actin content in stimulated T cells ..
  88. ncbi Deciphering the phosphorylation "code" of the glucocorticoid receptor in vivo
    Zhen Wang
    Department of Microbiology, Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 277:26573-80. 2002
    ..Phosphorylation of both residues increased upon treatment with the GR agonist dexamethasone. Using a battery of agonists and antagonists, we found that the transcriptional activity of GR correlated with ..
  89. pmc Hypothalamic-pituitary-adrenal axis dysregulation in depressed children and adolescents: a meta-analysis
    Nestor L Lopez-Duran
    University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, United States of America
    Psychoneuroendocrinology 34:1272-83. 2009
    ..We examined: (a) 17 published studies of HPA-axis response to the dexamethasone suppression test (DST) in depressed youth (DST; N=926) and (b) 17 studies of basal HPA-axis functioning (N=..
  90. doi Neonatal dexamethasone treatment for chronic lung disease of prematurity alters the hypothalamus-pituitary-adrenal axis and immune system activity at school age
    Rosa Karemaker
    Department of Neonatology, University Medical Center Utrecht, Utrecht, The Netherlands
    Pediatrics 121:e870-8. 2008
    To compare long-term effects of neonatal treatment with dexamethasone or hydrocortisone for chronic lung disease of prematurity on the hypothalamus-pituitary-adrenal axis and the immune response in children at school age.
  91. doi Finding the optimal postnatal dexamethasone regimen for preterm infants at risk of bronchopulmonary dysplasia: a systematic review of placebo-controlled trials
    Wes Onland
    Emma Children s Hospital, Academic Medical Center, Department of Neonatology, Amsterdam, Netherlands
    Pediatrics 123:367-77. 2009
    Postnatal dexamethasone therapy reduces the incidence of bronchopulmonary dysplasia in preterm infants but may be associated with an increased risk for adverse neurodevelopmental outcome.
  92. pmc Effect of dexamethasone on quality of life in children with acute lymphoblastic leukaemia: a prospective observational study
    Machteld A G de Vries
    Department of Paediatrics and Division of Oncology Haematology, VU University Medical Centre, Amsterdam, The Netherlands
    Health Qual Life Outcomes 6:103. 2008
    ..The maintenance phase of the Dutch ALL-9 protocol consisted of alternating two weeks on and five weeks off dexamethasone (6 mg/m(2)/day)...
  93. doi Evaluation of the safety and performance of an applicator for a novel intravitreal dexamethasone drug delivery system for the treatment of macular edema
    Julia A Haller
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland, USA
    Retina 29:46-51. 2009
    Evaluation of safety and performance of an applicator-inserted dexamethasone drug delivery system.
  94. doi Pharmacokinetics and pharmacodynamics of a sustained-release dexamethasone intravitreal implant
    Joan En Chang-Lin
    Department of Research and Development, Allergan, Inc, Irvine, CA, USA
    Invest Ophthalmol Vis Sci 52:80-6. 2011
    To determine the pharmacokinetics and pharmacodynamics of a sustained-release dexamethasone (DEX) intravitreal implant (Ozurdex; Allergan, Inc.).
  95. doi Double-blind, randomised, controlled study of the efficacy and tolerability of palonosetron plus dexamethasone for 1 day with or without dexamethasone on days 2 and 3 in the prevention of nausea and vomiting induced by moderately emetogenic chemotherapy
    M Aapro
    Division of Oncology, Institut Multidisciplinaire d Oncologie, Clinique de Genolier, Genolier, Switzerland
    Ann Oncol 21:1083-8. 2010
    ..We evaluated the possibility to reduce the total dose of corticosteroids when palonosetron, a long-acting second-generation 5-hydroxytryptamine-3 (5-HT(3)) receptor antagonist, is used...
  96. pmc Rapid non-genomic inhibition of ATP-induced Cl- secretion by dexamethasone in human bronchial epithelium
    V Urbach
    INSERM U454, CHU A de Villeneuve, 34295 Montpellier cedex 05, France
    J Physiol 545:869-78. 2002
    A non-genomic antisecretory role for dexamethasone at low concentrations (0.1 nM to1 microM) is described in monolayers of human bronchial epithelial cells in primary culture and in a continuous cell line (16HBE14o- cells)...
  97. ncbi Hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone and highly active antiretroviral therapy for patients with acquired immunodeficiency syndrome-related Burkitt lymphoma/leukemia
    Jorge Cortes
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 94:1492-9. 2002
    ..investigated the feasibility and efficacy of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (hyper-CVAD), a dose-intensive chemotherapy regimen, in patients with AIDS-associated Burkitt lymphoma/..
  98. ncbi Long-term adaptations in glucocorticoid receptor and mineralocorticoid receptor mRNA and negative feedback on the hypothalamo-pituitary-adrenal axis following neonatal maternal separation
    Charlotte O Ladd
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Biol Psychiatry 55:367-75. 2004
    ..We hypothesized that maternally separated rats experience adequate proactive glucocorticoid negative feedback but deficient "reactive" negative feedback, contributing to prolonged hypothalamic-pituitary-adrenal stress responses...
  99. ncbi Hydrocortisone and dexamethasone in very deformable drug carriers have increased biological potency, prolonged effect, and reduced therapeutic dosage
    Gregor Cevc
    Medizinische Biophysik, Technische Universitat Munchen, Ismaningerstr 22, D 81675 Munchen, Deutschland, E U, Germany
    Biochim Biophys Acta 1663:61-73. 2004
    We characterised biological properties of novel formulations of two low-potency glucocorticosteroids, dexamethasone and hydrocortisone, which have an equivalent dose ratio of 1:50 in vasoconstriction tests...
  100. ncbi Hyperresponsiveness of hypothalamic-pituitary-adrenal axis to combined dexamethasone/corticotropin-releasing hormone challenge in female borderline personality disorder subjects with a history of sustained childhood abuse
    Thomas Rinne
    GGZ Buitenamstel, Department of Psychiatry, Free University Amsterdam, The Netherlands
    Biol Psychiatry 52:1102-12. 2002
    ..In humans, PTSD and MDD are associated with decreased and increased resistance to glucocorticoid feedback, respectively, which might reflect persistent changes in neuroendocrine sequelae following childhood abuse...
  101. ncbi Dexamethasone conjugated poly(amidoamine) dendrimer as a gene carrier for efficient nuclear translocation
    Joon Sig Choi
    Department of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon 305 764, South Korea
    Int J Pharm 320:171-8. 2006
    ..In this study, a glucocorticoid, dexamethasone, was conjugated to polyamidoamine (PAMAM) dendrimer and the effect of the conjugation was investigated...

Research Grants81

  1. Regulation of HSV-1 Gene Expression and Replication by Nuclear Hormone Receptors
    SHAOCHUNG VICTOR HSIA; Fiscal Year: 2012
    ..Fifth, standard procedures used to induce HSV-1 reactivation, such as hyperthermia and dexamethasone treatment, also decrease TH levels...
  2. Endogenous Hemoglobin And Heme Detoxification After Intracerebral Hemorrhage
    Xiurong Zhao; Fiscal Year: 2009
    ..by Nrf2, whereas CD163 and CD91 expression is promoted by macrophage colony-stimulating factor (M-CSF) or Dexamethasone (DEX)...
  3. Endogenous Hemoglobin And Heme Detoxification After Intracerebral Hemorrhage
    Xiurong Zhao; Fiscal Year: 2010
    ..by Nrf2, whereas CD163 and CD91 expression is promoted by macrophage colony-stimulating factor (M-CSF) or Dexamethasone (DEX)...
  4. Transscleral Transport & Polymeric Delivery of Antibody & Steroids for Macular Ed
    Ashim Mitra; Fiscal Year: 2009
    ..the specific aims of this new grant application are: (1) to determine transscleral permeability of steroids (dexamethasone and prednisolone) and anti-VEGF monoclonal antibody (bevacizumab) (i) alone (ii) encapsulated in unmodified ..
  5. Transscleral Transport & Polymeric Delivery of Antibody & Steroids for Macular Ed
    Ashim K Mitra; Fiscal Year: 2010
    ..the specific aims of this new grant application are: (1) to determine transscleral permeability of steroids (dexamethasone and prednisolone) and anti-VEGF monoclonal antibody (bevacizumab) (i) alone (ii) encapsulated in unmodified ..
  6. Steroid Responsive Mechanisms in the Ear
    Dennis Trune; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Glucocorticoids (prednisone, methlyprednisolone, dexamethasone) have been employed for decades for control of hearing loss...
  7. Steroid Responsive Mechanisms in the Ear
    Dennis Trune; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Glucocorticoids (prednisone, methlyprednisolone, dexamethasone) have been employed for decades for control of hearing loss...
  8. Steroid Responsive Mechanisms in the Ear
    DENNIS ROYAL TRUNE; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Glucocorticoids (prednisone, methlyprednisolone, dexamethasone) have been employed for decades for control of hearing loss...
  9. PHTHALOCYANINE PHOTODYNAMIC THERAPY OF SKIN TUMORS
    Hasan Mukhtar; Fiscal Year: 1999
    ..of apoptosis, then by attempting to block apoptosis by basic fibroblast growth factor or enhance it by dexamethasone, with assessment of apoptosis by DNA fragmentation, histology, direct immunoperoxidase staining of digoxigenin-..
  10. Mechanisms of comorbidity between epilepsy and depression
    Andrey M Mazarati; Fiscal Year: 2010
    ..This will be achieved by measuring, using radioimmunoassay, both basal and dexamethasone/corticotropine releasing hormone (DEX/CRH)- induced increase of plasma corticosterone (CORT) levels during ..
  11. Mechanisms of comorbidity between epilepsy and depression
    Andrey M Mazarati; Fiscal Year: 2011
    ..This will be achieved by measuring, using radioimmunoassay, both basal and dexamethasone/corticotropine releasing hormone (DEX/CRH)- induced increase of plasma corticosterone (CORT) levels during ..
  12. Center Driven Project
    PAUL ANDREW CLEMONS; Fiscal Year: 2011
    ..former case, for example, one clinical trial was initiated based on the discovery that sirolimus converts a dexamethasone-resistant state of leukemia (ALL) - HRG-bl +HRG-D1 ce||Sj jdentjfjec| by its gene-expression signature, to a ..
  13. The effects of dexamethasone on tumor and microglial cells in glioma
    TERREIA SUTTON JONES; Fiscal Year: 2012
    ..Corticoisteroids such as dexamethasone (Dex) have remained the standard of care for resolving brain tumor-associated neurological symptoms for ..
  14. BIOLOGY OF TRABECULAR MESHWORK IN HEALTH AND DISEASE
    BEATRICE YUE; Fiscal Year: 1993
    ..Glucocorticoids such as dexamethasone induced intraocular pressure elevations in susceptible humans and rabbits, and the underlying alterations in ..
  15. BIOLOGY OF TRABECULAR MESHWORK IN HEALTH & DISEASE
    BEATRICE YUE; Fiscal Year: 1992
    ..Glucocorticoids such as dexamethasone induced intraocular pressure elevations in susceptible humans and rabbits, and the underlying alterations in ..
  16. Model systems for hematologic disorders caused by ribosomal protein deficiency
    George Thomas; Fiscal Year: 2009
    ..cells depleted of either small or large ribosomal subunit proteins;Aim2: Determine the effects of dexamethasone, lenalidomide, and leucine on the p53 response and on rpL5 and rpL11 translation in primary human ..
  17. Model systems for hematologic disorders caused by ribosomal protein deficiency
    George Thomas; Fiscal Year: 2010
    ..cells depleted of either small or large ribosomal subunit proteins;Aim2: Determine the effects of dexamethasone, lenalidomide, and leucine on the p53 response and on rpL5 and rpL11 translation in primary human ..
  18. Ocular Drug Delivery Devices for Improved Postoperative Cataract Care
    Buddy D Ratner; Fiscal Year: 2010
    ..One bead-shaped device will integrate dexamethasone for the prevention of inflammation...
  19. Investigating the Role of Adipocytes on Leukemia Relapse
    STEVEN DAVID MITTELMAN; Fiscal Year: 2010
    ..effects to impair chemotherapy of ALL: they secrete as yet unidentified factors which cause ALL resistance to dexamethasone, and they concentrate vincristine out of the extracellular environment, making it inaccessible to the ALL ..
  20. Investigating the Role of Adipocytes on Leukemia Relapse
    STEVEN MITTELMAN; Fiscal Year: 2009
    ..effects to impair chemotherapy of ALL: they secrete as yet unidentified factors which cause ALL resistance to dexamethasone, and they concentrate vincristine out of the extracellular environment, making it inaccessible to the ALL ..
  21. INTRAVITREAL DRUG DELIVERY
    Paul Ashton; Fiscal Year: 1993
    ..the following model compounds at a steady rate for 2 months in vivo: gentamicin, ganciclovir, flurbiprofen, dexamethasone, octreotide and cyclosporine A...
  22. DEXAMETHASONE/NGF REGULATE CASEIN KINASE IN PC12 CELLS
    Robert Van Buskirk; Fiscal Year: 1990
    ..Furthermore, work presented in this proposal (1) demonstrates that dexamethasone completely inhibits this nerve growth factor-induced increase in casein kinase activity and that (2) this ..
  23. INDUCTION OF ACUTE PHASE PROTEIN BIOSYNTHESIS
    Irving Kushner; Fiscal Year: 1990
    ..and extend our finding that conditioned medium prepared from LPS-activated human monocytes in the presence of dexamethasone, and lacking demonstrable I1-1, induces increased synthesis of CRP in two human hepatoma cell line Employing ..
  24. MODEL OF HYPERCORTISOLISM FOR MAJOR DEPRESSIONS
    Alan Schatzberg; Fiscal Year: 1999
    ..effects on the adrenal cortex, ACTH stimulation tests will also be administered after chronic separations to dexamethasone pretreated monkeys...
  25. STUDY OF DEXAMETHASONE IN NEONATAL LUPUS CHB
    Jill Buyon; Fiscal Year: 2002
    ..In Specific Aim 1, a randomized double-blind placebo-controlled trial will examine the effect of daily oral dexamethasone (4 mg) on the outcome of CHB...
  26. STUDY OF DEXAMETHASONE IN NEONATAL LUPUS CHB
    Jill Buyon; Fiscal Year: 2001
    ..In Specific Aim 1, a randomized double-blind placebo-controlled trial will examine the effect of daily oral dexamethasone (4 mg) on the outcome of CHB...
  27. STUDY OF DEXAMETHASONE IN NEONATAL LUPUS CHB
    Jill Buyon; Fiscal Year: 2004
    ..In Specific Aim 1, a randomized double-blind placebo-controlled trial will examine the effect of daily oral dexamethasone (4 mg) on the outcome of CHB...
  28. STUDY OF DEXAMETHASONE IN NEONATAL LUPUS CHB
    Jill Buyon; Fiscal Year: 2000
    ..In Specific Aim 1, a randomized double-blind placebo-controlled trial will examine the effect of daily oral dexamethasone (4 mg) on the outcome of CHB...
  29. IMPROVED STEROID THERAPY FOR HEARING LOSS
    Dennis Trune; Fiscal Year: 2000
    In spite of years of treating various forms of hearing loss with glucocorticoids (prednisone, dexamethasone), there is virtually no clinical or experimental evidence that inflammation of the ear is the underlying etiology...
  30. IMPROVED STEROID THERAPY FOR HEARING LOSS
    Dennis Trune; Fiscal Year: 1999
    In spite of years of treating various forms of hearing loss with glucocorticoids (prednisone, dexamethasone), there is virtually no clinical or experimental evidence that inflammation of the ear is the underlying etiology...
  31. STUDY OF DEXAMETHASONE IN NEONATAL LUPUS CHB
    Jill Buyon; Fiscal Year: 2003
    ..In Specific Aim 1, a randomized double-blind placebo-controlled trial will examine the effect of daily oral dexamethasone (4 mg) on the outcome of CHB...
  32. Radiovirotherapy for Multiple Myeloma
    Stephen J Russell; Fiscal Year: 2010
    ..Aim 2. To determine whether dexamethasone can ameliorate the bone marrow toxicity of I-131...
  33. Radiovirotherapy for Multiple Myeloma
    Stephen Russell; Fiscal Year: 2009
    ..Aim 2. To determine whether dexamethasone can ameliorate the bone marrow toxicity of I-131...
  34. PHYSIOLOGICAL/BIOCHRONOMETRIC ANALYSIS OF 6-METHOXY-2-BENZOXAZOLINONE EXPOSURE
    Fitzgerald Spencer; Fiscal Year: 1999
    The broad objective of this study will be to investigate whether dexamethasone, a synthetic glucocorticoid useful in chemical reproductive therapy in humans, can indirectly affect ovarian function...
  35. CARNITINE ACYLTRANSFERASE CHARACTERISTICS
    Linda Brady; Fiscal Year: 1991
    ..In H4IIE cells and hepatocytes CPT mRNA is induced by peroxisomal proliferators, cAMP, dexamethasone, epinephrine, fatty acids and dicarboxylic acids, and repressed by insulin...
  36. CORTICOSTEROIDS, STRESS, AND NICOTINE DEPENDENCE
    Ovide Pomerleau; Fiscal Year: 1992
    ..upon nicotine self-administration via smoking by administering different doses of a synthetic corticosteroid, dexamethasone (IA); to test the possibility that increased nicotine intake following dexamethasone is the result of non-..
  37. CORTICOSTEROIDS, STRESS, AND NICOTINE DEPENDENCE
    OVIDE POMERLAU; Fiscal Year: 1990
    ..upon nicotine self-administration via smoking by administering different doses of a synthetic corticosteroid, dexamethasone (IA); to test the possibility that increased nicotine intake following dexamethasone is the result of non-..
  38. TGF B1S ROLE IN PRIMARY AND REPARATIVE DENTINOGENESIS
    RENA D SOUZA; Fiscal Year: 1999
    ..Our studies of adult denition in TGF-beta1 (-/-) mice kept alive on dexamethasone show extensive pulp and periapical pathology and a marked attrition of occlusal surfaces...
  39. TGF B1'S ROLE IN PRIMARY AND REPARATIVE DENTINOGENESIS
    RENA D SOUZA; Fiscal Year: 2001
    ..Our studies of adult denition in TGF-beta1 (-/-) mice kept alive on dexamethasone show extensive pulp and periapical pathology and a marked attrition of occlusal surfaces...
  40. TGF B1'S ROLE IN PRIMARY AND REPARATIVE DENTINOGENESIS
    RENA D SOUZA; Fiscal Year: 2000
    ..Our studies of adult denition in TGF-beta1 (-/-) mice kept alive on dexamethasone show extensive pulp and periapical pathology and a marked attrition of occlusal surfaces...
  41. CYTOKINE REGULATION OF P450 IN CULTURED RAT HEPATOCYTES
    Joseph Williams; Fiscal Year: 1993
    ..Rat hepatocytes will be cultured on Matrigel matrix in Williams E medium containing insulin and dexamethasone. Recently, such rat hepatocyte cultures been shown to be inducible by phenobarbital (PB) for P450IIB 1/2 to ..
  42. FETAL MEMBRANE GROWTH & ACCOMMODATION DURING PREGNANCY: COLLAGEN REMODEL, CANCER
    Lynnae Millar; Fiscal Year: 2004
    ..This proposal attempts to study long-term effects of dexamethasone exposure in the neonatal period, particularly regarding vulnerability to stress during later development...
  43. Prophylaxis of adrenal insufficiency to prevent CLD
    Kristi Watterberg; Fiscal Year: 2004
    ..Early treatment with dexamethasone may decrease CLD; however, this therapy has serious immediate and long-term adverse effects...
  44. Prophylaxis of adrenal insufficiency to prevent CLD
    Kristi Watterberg; Fiscal Year: 2002
    ..Early treatment with dexamethasone may decrease CLD; however, this therapy has serious immediate and long-term adverse effects...
  45. Prophylaxis of adrenal insufficiency to prevent CLD
    Kristi Watterberg; Fiscal Year: 2001
    ..Early treatment with dexamethasone may decrease CLD; however, this therapy has serious immediate and long-term adverse effects...
  46. Prophylaxis of adrenal insufficiency to prevent CLD
    Kristi Watterberg; Fiscal Year: 2003
    ..Early treatment with dexamethasone may decrease CLD; however, this therapy has serious immediate and long-term adverse effects...
  47. Prophylaxis of adrenal insufficiency to prevent CLD
    Kristi Watterberg; Fiscal Year: 2005
    ..Early treatment with dexamethasone may decrease CLD; however, this therapy has serious immediate and long-term adverse effects...
  48. Glucocorticoids & Vitamin D: Role in Antitumor Effects
    Candace Johnson; Fiscal Year: 2007
    ..In vitro and in vivo, dexamethasone (dex) potentiates calcitriol-mediated antitumor activity through the vitamin D receptor (VDR)...
  49. GLUCOCORTICOIDS & VITAMIN D: ROLE IN ANTI-TUMOR EFFECTS
    Candace Johnson; Fiscal Year: 2009
    ..In vitro and in vivo, dexamethasone (dex) potentiates calcitriol-mediated antitumor activity through the vitamin D receptor (VDR)...
  50. INNER EAR FLUID INTERACTIONS
    Alec N Salt; Fiscal Year: 2010
    ..elimination from the ear, pharmacokinetic studies of the clinically relevant drugs gentamicin (a cation) and dexamethasone (an anion) will be performed using sequential sampling methods...
  51. Response of Major Histocompatibility Complex (MHC) to DEX & PCN in Non-APC(pilot)
    BRAULIO JIMENEZ; Fiscal Year: 2004
    ..control of PCN employed differential display to detect rat liver mRNA species selectively induced by PCN or by Dexamethasone(DEX). These studies revealed the induction of RT1...
  52. GLUCOCORTICOIDS & VITAMIN D: ROLE IN ANTI-TUMOR EFFECTS
    Candace Johnson; Fiscal Year: 2006
    ..In vitro and in vivo, dexamethasone (dex) potentiates calcitriol-mediated antitumor activity through the vitamin D receptor (VDR)...
  53. GLUCOCORTICOIDS & VITAMIN D: ROLE IN ANTI-TUMOR EFFECTS
    Candace Johnson; Fiscal Year: 2005
    ..In vitro and in vivo, dexamethasone (dex) potentiates calcitriol-mediated antitumor activity through the vitamin D receptor (VDR)...
  54. Development of a novel anti-inflammatory treatment for clinical management of end
    Rafal Farjo; Fiscal Year: 2009
    ..To address inflammation, the administration of a steroid, such as dexamethasone, is often given concurrently with antibiotics;however, multiple studies have demonstrated that dexamethasone ..
  55. MUSCLE PROTEIN TURNOVER AND AMINO ACID UPTAKE IN SEPSIS
    Per Olof Hasselgren; Fiscal Year: 2009
    ..Studies are performed in two models of muscle wasting, i.e., in septic rats and in dexamethasone-treated cultured myotubes...
  56. Evaluation of CYP24 as a Target for Enhancing Vitamin D
    Donald Trump; Fiscal Year: 2005
    ..g. taxanes, platinum analogues, antracenediones). High dose dexamethasone (Dex) potentiates the antitumor effects and blunts calcitriol-induced hypercalcemia...
  57. Evaluation of CYP24 as a Target for Enhancing Vitamin D*
    Donald Trump; Fiscal Year: 2006
    ..g. taxanes, platinum analogues, antracenediones). High dose dexamethasone (Dex) potentiates the antitumor effects and blunts calcitriol-induced hypercalcemia...
  58. MUSCLE PROTEIN TURNOVER AND AMINO ACID UPTAKE IN SEPSIS
    Per Olof Hasselgren; Fiscal Year: 2006
    ..Studies are performed in two models of muscle wasting, i.e., in septic rats and in dexamethasone-treated cultured myotubes...
  59. MUSCLE PROTEIN TURNOVER AND AMINO ACID UPTAKE IN SEPSIS
    Per Olof Hasselgren; Fiscal Year: 2007
    ..Studies are performed in two models of muscle wasting, i.e., in septic rats and in dexamethasone-treated cultured myotubes...
  60. Regulation of NHE3 by glucocorticoids, SGK1 and NHERF2
    CHANGHYON YUN; Fiscal Year: 2006
    ..However, we recently found using Caco-2 cells that dexamethasone activates NHE3 transport without affecting NHE3 mRNA expression...
  61. COLON-SPECIFIC DRUG DELIVERY
    David Friend; Fiscal Year: 1992
    ..The specific aims of the proposed work are to (1)synthesize the beta-D-glucuronides of dexamethasone and flunisolide, (2) study the hydrolysis of the prodrugs under in vitro conditions in rat (normal, germfree, ..
  62. Regulation of NHE3 by glucocorticoids, SGK1 and NHERF2
    CHANGHYON YUN; Fiscal Year: 2003
    ..However, we recently found using Caco-2 cells that dexamethasone activates NHE3 transport without affecting NHE3 mRNA expression...
  63. MECHANISMS OF ACTH REGULATION: MEDICATION EFFECT
    Roger Kathol; Fiscal Year: 1992
    ..releasing hormone (oCRH) tests; 36 will have 8 insulin tolerance tests (ITTs); and 36 will have 6 dexamethasone suppression tests (DSTs) and 3 lumbar punctures (LPs)...
  64. AROMATASE IN ADIPOSE--RELATIONSHIP TO AGING AND CANCER
    Evan Simpson; Fiscal Year: 1993
    ..promoter selection appears to be dictated by the culture conditions, namely the presence or absence of cAMP, dexamethasone and growth factors...
  65. Regulation of NHE3 by glucocorticoids, SGK1 and NHERF2
    CHANGHYON YUN; Fiscal Year: 2004
    ..However, we recently found using Caco-2 cells that dexamethasone activates NHE3 transport without affecting NHE3 mRNA expression...
  66. AROMATASE IN ADIPOSE--RELATIONSHIP TO AGING AND CANCER
    Evan Simpson; Fiscal Year: 2002
    ..promoter selection appears to be dictated by the culture conditions, namely the presence or absence of cAMP, dexamethasone and growth factors...
  67. AROMATASE IN ADIPOSE--RELATIONSHIP TO AGING AND CANCER
    Evan Simpson; Fiscal Year: 2005
    ..promoter selection appears to be dictated by the culture conditions, namely the presence or absence of cAMP, dexamethasone and growth factors...
  68. AROMATASE IN ADIPOSE--RELATIONSHIP TO AGING AND CANCER
    Evan Simpson; Fiscal Year: 2001
    ..promoter selection appears to be dictated by the culture conditions, namely the presence or absence of cAMP, dexamethasone and growth factors...
  69. AROMATASE IN ADIPOSE--RELATIONSHIP TO AGING AND CANCER
    Evan Simpson; Fiscal Year: 2003
    ..promoter selection appears to be dictated by the culture conditions, namely the presence or absence of cAMP, dexamethasone and growth factors...
  70. Regulation of NHE3 by glucocorticoids, SGK1 and NHERF2
    CHANGHYON YUN; Fiscal Year: 2005
    ..However, we recently found using Caco-2 cells that dexamethasone activates NHE3 transport without affecting NHE3 mRNA expression...
  71. AROMATASE IN ADIPOSE--RELATIONSHIP TO AGING AND CANCER
    Evan Simpson; Fiscal Year: 1999
    ..promoter selection appears to be dictated by the culture conditions, namely the presence or absence of cAMP, dexamethasone and growth factors...
  72. Regulation of NHE3 by glucocorticoids, SGK1 and NHERF2
    CHANGHYON YUN; Fiscal Year: 2007
    ..However, we recently found using Caco-2 cells that dexamethasone activates NHE3 transport without affecting NHE3 mRNA expression...
  73. AROMATASE IN ADIPOSE--RELATIONSHIP TO AGING AND CANCER
    Evan Simpson; Fiscal Year: 2000
    ..promoter selection appears to be dictated by the culture conditions, namely the presence or absence of cAMP, dexamethasone and growth factors...
  74. CONTROL OF HUMAN MUSCLE CELL GROWTH AND DIFFERENTIATION
    RICHARD HAM; Fiscal Year: 1990
    ..growth medium for HMSC, consisting of optimize nutrient medium MCDB 120 plus epidermal growth factor (EGF), dexamethasone, insulin, fetuin, and serum albumin, will be used as the starting point for these studies...
  75. Lipid storage and mobilization in M. tuberculosis as antilatency drugs targets
    Pappachan Kolattukudy; Fiscal Year: 2009
    ..will be tested for their ability to successfully go through dormancy and reactivation in a rabbit containment/dexamethasone reactivation model of TB latency...
  76. Lipid storage and mobilization in M. tuberculosis as antilatency drugs targets
    PAPPACHAN KOLATTUKUDY KOLATTUKUDY; Fiscal Year: 2010
    ..will be tested for their ability to successfully go through dormancy and reactivation in a rabbit containment/dexamethasone reactivation model of TB latency...