Genomes and Genes
Summary: A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.
Articles from Journal RESEARCH
Articles from Journal RESEARCH1
Publications387 found, 100 shown here
- Empirical estimation of free testosterone from testosterone and sex hormone-binding globulin immunoassaysLam P Ly
Department of Andrology, Concord Hospital and ANZAC Research Institute, University of Sydney, Sydney NSW 2139, Australia
Eur J Endocrinol 152:471-8. 2005The growing interest in measuring blood free testosterone (FT) is constrained by the unsuitability of the laborious reference methods for wider adoption in routine diagnostic laboratories...
- Adverse events associated with testosterone administrationShehzad Basaria
Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts 02118, USA
N Engl J Med 363:109-22. 2010b>Testosterone supplementation has been shown to increase muscle mass and strength in healthy older men. The safety and efficacy of testosterone treatment in older men who have limitations in mobility have not been studied.
- Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancerMichael Stanbrough
Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Cancer Res 66:2815-25. 2006..aldo-keto reductase family 1, member C3 (AKR1C3), the prostatic enzyme that reduces adrenal androstenedione to testosterone, was confirmed by real-time reverse transcription-PCR and immunohistochemistry...
- Design and end points of clinical trials for patients with progressive prostate cancer and castrate levels of testosterone: recommendations of the Prostate Cancer Clinical Trials Working GroupHoward I Scher
Genitourinary Oncology Service, Department of Medicine, Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA
J Clin Oncol 26:1148-59. 2008To update eligibility and outcome measures in trials that evaluate systemic treatment for patients with progressive prostate cancer and castrate levels of testosterone.
- Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging studyHenry A Feldman
New England Research Institutes, Watertown, Massachusetts 02472, USA
J Clin Endocrinol Metab 87:589-98. 2002..The paradoxical finding that longitudinal age trends were steeper than cross-sectional trends suggests that incident poor health may accelerate the age-related decline in androgen levels...
- A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapyC W Gregory
Laboratory for Reproductive Biology, Department of Pediatrics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
Cancer Res 61:4315-9. 2001..depends on the androgen receptor and its high-affinity binding of dihydrotestosterone, which derives from testosterone. Most prostate tumors regress after therapy to prevent testosterone production by the testes, but the tumors ..
- Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guidelineShalender Bhasin
Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Clin Endocrinol Metab 95:2536-59. 2010..Our objective was to update the guidelines for the evaluation and treatment of androgen deficiency syndromes in adult men published previously in 2006...
- Clinical review 1: Adverse effects of testosterone therapy in adult men: a systematic review and meta-analysisM Mercè Fernández-Balsells
Knowledge and Encounter Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
J Clin Endocrinol Metab 95:2560-75. 2010The risks of testosterone therapy in men remain poorly understood.
- Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: a randomized, double-blind, placebo-controlled studyUpendram Srinivas-Shankar
Andrology Research Unit, Department of Medicine and Endocrinology, University of Manchester, Manchester Royal Infirmary, Grafton Street, Manchester, United Kingdom M13 9WL
J Clin Endocrinol Metab 95:639-50. 2010Physical frailty is associated with reduced muscle strength, impaired physical function, and quality of life. Testosterone (T) increases muscle mass and strength in hypogonadal patients...
- Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of AgingS M Harman
The Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
J Clin Endocrinol Metab 86:724-31. 2001Many studies have shown cross-sectional (and two small studies, longitudinal) declines in total and/or free testosterone (T) levels, with age, in men...
- Effects of 1α,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cellsWei Lin W Wang
Department of Biomedical Sciences, University at Albany, State University of New York, Albany, NY 12222, USA
Mol Cancer 10:58. 2011There is evidence from epidemiological and in vitro studies that the biological effects of testosterone (T) on cell cycle and survival are modulated by 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) in prostate cancer...
- Comparison of serum testosterone and estradiol measurements in 3174 European men using platform immunoassay and mass spectrometry; relevance for the diagnostics in aging menIlpo T Huhtaniemi
Department of Surgery and Cancer, Imperial College London, Hammersmith Campus, London, UK
Eur J Endocrinol 166:983-91. 2012The limitations of serum testosterone and estradiol (E(2)) measurements using non-extraction platform immunoassays (IAs) are widely recognized...
- Fetal programming effects of testosterone on the reward system and behavioral approach tendencies in humansMichael V Lombardo
Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
Biol Psychiatry 72:839-47. 2012..One potential mechanism underlying such observations is testosterone in early development...
- Association of testosterone therapy with mortality, myocardial infarction, and stroke in men with low testosterone levelsRebecca Vigen
The University of Texas at Southwestern Medical Center, Dallas
JAMA 310:1829-36. 2013Rates of testosterone therapy are increasing and the effects of testosterone therapy on cardiovascular outcomes and mortality are unknown...
- Effects of testosterone supplementation on markers of the metabolic syndrome and inflammation in hypogonadal men with the metabolic syndrome: the double-blinded placebo-controlled Moscow studySvetlana Y Kalinchenko
The Faculty of Medical Staff Refresher Training, People s Friendship University of Russia Medical Clinic of Reproduction MAMA, Moscow, Russia
Clin Endocrinol (Oxf) 73:602-12. 2010Men with the metabolic syndrome (MetS) have low plasma testosterone (T) levels. The aim of this study was to establish whether the normalization of plasma T improves the features of the MetS.
- Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged menDavid E Laaksonen
Department of Medicine, Kuopio University Hospital, Kuopio, Finland
Diabetes Care 27:1036-41. 2004..We assessed the association of low levels of testosterone and sex hormone-binding globulin (SHBG) with the development of the metabolic syndrome and diabetes in men.
- Low testosterone in men with type 2 diabetes: significance and treatmentMathis Grossmann
Department of Medicine, Austin Health Northern Health, University of Melbourne, Heidelberg, VIC 3084, Australia
J Clin Endocrinol Metab 96:2341-53. 2011The relationship between testosterone and diabetes in men is an important issue, given that one third of U.S. men aged 65 yr or older have diabetes, with a similar percentage having low testosterone levels.
- In men older than 70 years, total testosterone remains stable while free testosterone declines with age. The Health in Men StudyBu B Yeap
School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia
Eur J Endocrinol 156:585-94. 2007An age-related decline in serum total and free testosterone concentration may contribute to ill health in men, but limited data are available for men > 70 years of age...
- Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidismMichelle Welsh
MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh, United Kingdom
J Clin Invest 118:1479-90. 2008..Based on the timings in rats, we believe the programming window in humans is likely to be 8-14 weeks of gestation...
- Serum testosterone, dihydrotestosterone and estradiol concentrations in older men self-reporting very good health: the healthy man studyGideon Sartorius
Andrology Department, Concord Hospital, Clayton, Vic, Australia
Clin Endocrinol (Oxf) 77:755-63. 2012To determine serum concentrations, intra-individual variability and impact of age-related co-morbidities on serum testosterone (T), dihydrotestosterone (DHT), estradiol (E(2)) and estrone (E(1)) in older men.
- Reference ranges and determinants of testosterone, dihydrotestosterone, and estradiol levels measured using liquid chromatography-tandem mass spectrometry in a population-based cohort of older menBu B Yeap
School of Medicine and Pharmacology, Level 2, T Block, Fremantle Hospital, Alma Street, Fremantle, Western Australia 6160, Australia
J Clin Endocrinol Metab 97:4030-9. 2012b>Testosterone (T) levels decline with increasing age. Controversy exists over the threshold for classifying T as low vs. normal in older men. The relevance of assessing dihydrotestosterone (DHT) and estradiol (E2) remains unclear.
- Testosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trialsLin Xu
School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China
BMC Med 11:108. 2013b>Testosterone therapy is increasingly promoted...
- Kiss1-/- mice exhibit more variable hypogonadism than Gpr54-/- miceRisto Lapatto
Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
Endocrinology 148:4927-36. 2007..Kiss1 knockout females demonstrate a bimodal phenotypic variability, with some animals having higher gonadal weight, larger vaginal opening, and persistent vaginal cornification...
- Effect of testosterone supplementation on functional mobility, cognition, and other parameters in older men: a randomized controlled trialMarielle H Emmelot-Vonk
Department of Geriatric Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
JAMA 299:39-52. 2008Serum testosterone levels decline significantly with aging. Testosterone supplementation to older men might beneficially affect the aging processes.
- Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancerKai Hsiung Chang
Division of Hematology and Oncology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8852, USA
Proc Natl Acad Sci U S A 108:13728-33. 2011..of cases, advanced prostate cancer responds initially to androgen deprivation therapy by depletion of gonadal testosterone. The response is usually transient, and metastatic tumors almost invariably eventually progress as castration-..
- Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophyMasahisa Katsuno
Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan
Neuron 35:843-54. 2002..Female transgenic mice showed only a few manifestations that markedly deteriorated with testosterone administration...
- Testosterone and dominance in menA Mazur
Public Affairs Program, Syracuse University, NY 13244, USA
Behav Brain Sci 21:353-63; discussion 363-97. 1998In men, high levels of endogenous testosterone (T) seem to encourage behavior intended to dominate--to enhance one's status over--other people...
- Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trialsOlga M Calof
Boston University, School of Medicine, E201, 88 E Newton Street, Boston, MA 02118, USA
J Gerontol A Biol Sci Med Sci 60:1451-7. 2005We performed a meta-analysis of randomized clinical trials to determine the risks of adverse events associated with testosterone replacement in older men.
- The role of testosterone in social interactionChristoph Eisenegger
Behavioral and Clinical Neuroscience Institute, Department of Experimental Psychology, Downing Street, University of Cambridge, CB2 3EB, UK
Trends Cogn Sci 15:263-71. 2011Although animal researchers established the role of testosterone as a 'social hormone' decades ago, the investigation of its causal influence on human social behaviors has only recently begun...
- Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifosD Dai
National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
J Pharmacol Exp Ther 299:825-31. 2001..b>Testosterone and the insecticide chlorpyrifos were used to assess the catalytic activities of the most common CYP3A4 allele (..
- Measurement of total serum testosterone in adult men: comparison of current laboratory methods versus liquid chromatography-tandem mass spectrometryChristina Wang
Division of Endocrinology, Department of Medicine, Harbor UCLA Medical Center and Research and Education Institute, Torrance, California 90502, USA
J Clin Endocrinol Metab 89:534-43. 2004The diagnosis of male hypogonadism requires the demonstration of a low serum testosterone (T) level...
- Positive relationship between androgen and the endocrine disruptor, bisphenol A, in normal women and women with ovarian dysfunctionToru Takeuchi
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Japan
Endocr J 51:165-9. 2004..There were significant positive correlations between serum BPA and total testosterone (r = 0.391, p<0.001), free testosterone (r = 0.504, p<0.001), androstenedione (r = 0.684, p<0...
- Testosterone treatment improves body composition and sexual function in men with COPD, in a 6-month randomized controlled trialJ Svartberg
Department of Medicine, University Hospital of North Norway, N 9038 Tromsø, Norway
Respir Med 98:906-13. 2004The aim of this study was to assess the effect of a low-dose testosterone on body composition and pulmonary function, as well as on quality of life, sexuality, and psychological symptoms in patients with chronic obstructive pulmonary ..
- Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancerElahe A Mostaghel
Fred Hutchinson Cancer Research Center, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
Cancer Res 67:5033-41. 2007..Medical castration based on serum testosterone levels cannot be equated with androgen ablation in the prostate microenvironment...
- Androgens inhibit androgen receptor promoter activation in motor neuronsGuglielmo Vismara
Department of Endocrinology, Pathophysiology and Applied Biology Center of Excellence on Neurodegenerative Diseases of the University of Milan Via Balzaretti 9, 20133, Italy
Neurobiol Dis 33:395-404. 2009..b>Testosterone, dihydrotestosterone (DHT), but not estradiol, inhibited AR promoter activation...
- Selective inhibition of CYP17 with abiraterone acetate is highly active in the treatment of castration-resistant prostate cancerGerhardt Attard
Royal Marsden National Health Service Foundation Trust, Sutton, Surrey, United Kingdom
J Clin Oncol 27:3742-8. 2009..Abiraterone acetate is a potent, selective, and orally available inhibitor of CYP17, the key enzyme in androgen and estrogen biosynthesis...
- Characteristics of secondary, primary, and compensated hypogonadism in aging men: evidence from the European Male Ageing StudyAbdelouahid Tajar
The University of Manchester, Manchester Academic Health Science Centre, Department of Endocrinology, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, United Kingdom
J Clin Endocrinol Metab 95:1810-8. 2010The diagnosis of late-onset hypogonadism (LOH) in older men with age-related declines in testosterone (T) is currently not well characterized.
- Type 2 diabetes mellitus and testosterone: a meta-analysis studyG Corona
Andrology Unit and Endocrinology, Department of Clinical Physiopathology, University of Florence, Florence, Italy
Int J Androl 34:528-40. 2011..Despite the well-known link, the role of testosterone replacement therapy (TRT) in T2DM has not been completely clarified...
- Testosterone replacement in hypogonadal men with type 2 diabetes and/or metabolic syndrome (the TIMES2 study)T Hugh Jones
The Robert Hague Centre for Diabetes and Endocrinology, Barnsley Hospital, Barnsley, UK
Diabetes Care 34:828-37. 2011This study evaluated the effects of testosterone replacement therapy (TRT) on insulin resistance, cardiovascular risk factors, and symptoms in hypogonadal men with type 2 diabetes and/or metabolic syndrome (MetS).
- Testosterone, cardiovascular disease and the metabolic syndromeGiovanni Corona
Andrology and Sexual Medicine Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
Best Pract Res Clin Endocrinol Metab 25:337-53. 2011Recent evidence suggests that low, rather than high, testosterone (T) is associated with increased male morbidity and mortality...
- Sex hormone-binding globulin, but not testosterone, is associated prospectively and independently with incident metabolic syndrome in men: the framingham heart studyShalender Bhasin
Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, MA, USA
Diabetes Care 34:2464-70. 2011The association between total testosterone and metabolic syndrome has prompted speculation that low testosterone contributes to the pathophysiology of metabolic syndrome in men...
- Testosterone inhibits transforming growth factor-β signaling during myogenic differentiation and proliferation of mouse satellite cells: potential role of follistatin in mediating testosterone actionMelissa Braga
Division of Endocrinology and Metabolism, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, United States
Mol Cell Endocrinol 350:39-52. 2012b>Testosterone (T) administration is associated with increased satellite cell number and skeletal muscle hypertrophy, although there is considerable heterogeneity in the response of different skeletal muscle groups to T in vivo...
- Testosterone treatment and mortality in men with low testosterone levelsMolly M Shores
Veterans Affairs Puget Sound Health Care System, 1660 South Columbian Way, S 116PES, Seattle, Washington 98108, USA
J Clin Endocrinol Metab 97:2050-8. 2012Low testosterone levels in men have been associated with increased mortality. However, the influence of testosterone treatment on mortality in men with low testosterone levels is not known.
- Antiinflammatory effect of androgen receptor activation in human benign prostatic hyperplasia cellsLinda Vignozzi
Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy
J Endocrinol 214:31-43. 2012..demonstrated that prostate inflammation and tissue remodeling are exacerbated by hypogonadism and prevented by testosterone supplementation...
- Testosterone and dihydrotestosterone tissue levels in recurrent prostate cancerMark A Titus
Department of Pathology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, 27599 7295, USA
Clin Cancer Res 11:4653-7. 2005..Many groups have pursued mechanisms of ligand-independent androgen receptor activation but we found high levels of testicular androgens in recurrent prostate cancer tissue using RIA...
- Association of sex hormones and C-reactive protein levels in menVarant Kupelian
New England Research Institutes, Watertown, MA 02472, USA
Clin Endocrinol (Oxf) 72:527-33. 2010..The objective of this analysis was to investigate the association between sex hormone levels and C-reactive protein (CRP) in a population-based sample of men...
- Studies on prostatic cancer: I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. 1941Charles Huggins
J Urol 168:9-12. 2002
- Changes in muscle mass, muscle strength, and power but not physical function are related to testosterone dose in healthy older menThomas W Storer
Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, Massachusetts, USA
J Am Geriatr Soc 56:1991-9. 2008To examine the effect of graded doses of testosterone on physical function and muscle performance in healthy, older men.
- Growth of white matter in the adolescent brain: role of testosterone and androgen receptorJennifer S Perrin
Brain and Body Centre, University of Nottingham, Nottingham NG72RD, United Kingdom
J Neurosci 28:9519-24. 2008..Here, we provide evidence supporting the role of androgen receptor (AR) in mediating the effect of testosterone on white matter...
- Genetic determinants of serum testosterone concentrations in menClaes Ohlsson
Center for Bone and Arthritis Research, Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden
PLoS Genet 7:e1002313. 2011b>Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity...
- Testosterone-mediated neuroprotection through the androgen receptor in human primary neuronsJ Hammond
Bloomfield Center for Research in Aging, The Lady Davis Institute for Medical Research, Sir Mortimer B Davis, Jewish General Hospital, Montreal, Quebec, Canada
J Neurochem 77:1319-26. 2001..To determine if male hormones could also be neuroprotective, we investigated the effect of testosterone, methyltestosterone, and epitestosterone at physiological concentrations on primary cultures of human neurons ..
- Effect of sodium arsenite on spermatogenesis, plasma gonadotrophins and testosterone in ratsMahitosh Sarkar
Reproductive Physiology Unit, Dept of Physiology, University Colleges of Science and Technology, Calcutta University, 92 Acharya Prafulla Chandra Road, Calcutta 700009, India
Asian J Androl 5:27-31. 2003..To investigate the effect of arsenic on spermatogenesis...
- 2nd to 4th digit ratios, fetal testosterone and estradiolS Lutchmaya
Developmental Psychiatry Section, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge CB2 2AH, UK
Early Hum Dev 77:23-8. 2004..There is indirect evidence that 2D:4D is established in utero and is negatively related to prenatal testosterone and positively with prenatal estradiol...
- The relationship between testosterone and molecular markers of inflammation in older menM Maggio
Longitudinal Studies Section, Clinical Research Branch, CRB, National Institute on Aging, NIA, USA
J Endocrinol Invest 28:116-9. 2005..At the same time, aging is associated with a decrease in serum testosterone (T) levels...
- Mechanisms of obesity and related pathologies: androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunctionAbdulmaged M Traish
Department of Biochemistry and Urology, Boston University School of Medicine, MA 02118, USA
FEBS J 276:5755-67. 2009..Furthermore, obesity is also associated with reduced plasma testosterone levels, which contributes to hypogonadism and increases the risk of vascular pathology...
- Testosterone dose-response relationships in healthy young menS Bhasin
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
Am J Physiol Endocrinol Metab 281:E1172-81. 2001b>Testosterone increases muscle mass and strength and regulates other physiological processes, but we do not know whether testosterone effects are dose dependent and whether dose requirements for maintaining various androgen-dependent ..
- Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissuesShuyuan Yeh
Departments of Urology and Pathology, George H Whipple Lab for Cancer Research, University of Rochester, Rochester, NY 14642, USA
Proc Natl Acad Sci U S A 99:13498-503. 2002..Their testes are 80% smaller and serum testosterone concentrations are lower than in wild-type (wt) mice. Spermatogenesis is arrested at pachytene spermatocytes...
- The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal menChris J Malkin
Cardiology Department, Royal Hallamshire Hospital, Sheffield, United Kingdom S10 2JF
J Clin Endocrinol Metab 89:3313-8. 2004b>Testosterone has immune-modulating properties, and current in vitro evidence suggests that testosterone may suppress the expression of the proinflammatory cytokines TNFalpha, IL-1beta, and IL-6 and potentiate the expression of the ..
- Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum TStephanie T Page
Wesley Woods Health Center, 1841 Clifton Road Northeast, Atlanta, Georgia 30329 5102, USA
J Clin Endocrinol Metab 90:1502-10. 2005b>Testosterone (T) therapy in older men with low serum T levels increases lean body mass and decreases fat mass...
- Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a meta-analysisAndrea M Isidori
Cattedra di Andrologia, Universita La Sapienza, Rome, Italy
Clin Endocrinol (Oxf) 63:280-93. 2005Ageing in men is associated with a gradual decline in serum testosterone levels and a concomitant loss of muscle mass, accumulation of central adiposity, impaired mobility and increased risk of bone fractures...
- Large differences in testosterone excretion in Korean and Swedish men are strongly associated with a UDP-glucuronosyl transferase 2B17 polymorphismJenny Jakobsson
Clinical Pharmacology, C1 68, Karolinska Institutet at Karolinska University Hospital, S 141 86 Stockholm, Sweden
J Clin Endocrinol Metab 91:687-93. 2006..Uridine diphosphoglucuronosyl transferases have a key role in the homeostasis and metabolism of androgens. Recently a deletion polymorphism was detected in the UGT2B17 gene...
- Testosterone and human aggression: an evaluation of the challenge hypothesisJohn Archer
Department of Psychology, University of Central Lancashire, Preston, Lancashire PR12HE, UK
Neurosci Biobehav Rev 30:319-45. 2006Research on testosterone-behavior relationships in humans is assessed in relation to a version of the challenge hypothesis, originally proposed to account for testosterone-aggression associations in monogamous birds...
- Identification of late-onset hypogonadism in middle-aged and elderly menFrederick C W Wu
Andrology Research Unit, Developmental and Regenerative Biomedicine Research Group, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom
N Engl J Med 363:123-35. 2010The association between aging-related testosterone deficiency and late-onset hypogonadism in men remains a controversial concept...
- Effects of transdermal testosterone on bone and muscle in older men with low bioavailable testosterone levels, low bone mass, and physical frailtyAnne M Kenny
Center on Aging, MC 5215, University of Connecticut Health Center, Farmington, CT 06030, USA
J Am Geriatr Soc 58:1134-43. 2010To investigate the effects of testosterone supplementation on bone, body composition, muscle, physical function, and safety in older men.
- Testosterone and metabolic syndrome: a meta-analysis studyGiovanni Corona
Andrology and Sexual Medicine Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
J Sex Med 8:272-83. 2011Metabolic syndrome (MetS) is often associated with male hypogonadism. Despite the well-known link, the role of testosterone replacement therapy (TRT) in MetS has not been completely clarified.
- Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathwayRajan Singh
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
Endocrinology 144:5081-8. 2003b>Testosterone supplementation increases skeletal muscle mass and decreases fat mass; however, the underlying mechanisms are unknown...
- Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancerMotohide Uemura
Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Shirokanedai 4 6 1 Minato ku, Tokyo 108 8639, Japan
Cancer Sci 99:81-6. 2008..5 alpha-steroid reductase that produces the most potent androgen, 5 alpha-dihydrotestosterone (DHT), from testosterone. Liquid chromatography-tandem mass spectrometry analysis following an in vitro 5 alpha-steroid reductase ..
- Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetesD Kapoor
Centre for Diabetes and Endocrinology, Barnsley NHS Foundation Trust Hospital, Gawber Road, Barnsley S75 2EP, UK
Eur J Endocrinol 154:899-906. 2006Low levels of testosterone in men have been shown to be associated with type 2 diabetes, visceral adiposity, dyslipidaemia and metabolic syndrome...
- The mismatch effect: when testosterone and status are at oddsRobert A Josephs
Department of Psychology, The University of Texas at Austin, USA
J Pers Soc Psychol 90:999-1013. 2006..studies, the authors examined the psychological and physiological consequences of a mismatch between baseline testosterone and a person's current level of status...
- Non-genomic actions of androgensC D Foradori
Department of Biomedical Sciences, Neurobiology Section, Colorado State University, Fort Collins, CO 80523, USA
Front Neuroendocrinol 29:169-81. 2008..and neuroendocrine fields has viewed the androgen receptor (AR) as a transcription factor activated by testosterone or one of its many metabolites...
- Testosterone and type 2 diabetesMathis Grossmann
Department of Medicine, Austin Health Northern Health, University of Melbourne, Heidelberg, Victoria, Australia
Curr Opin Endocrinol Diabetes Obes 17:247-56. 2010To describe the relationship between testosterone levels and type 2 diabetes (T2D).
- Inhibition of human and rat testicular steroidogenic enzyme activities by bisphenol ALeping Ye
The 2nd Affiliated Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, PR China
Toxicol Lett 207:137-42. 2011Bisphenol A (BPA) is a potential endocrine disruptor. It has been shown that it reduces serum testosterone level in rodents after exposure. However, the mechanism is unclear...
- Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly menA W van den Beld
Department of Internal Medicine III, Erasmus University Rotterdam, The Netherlands
J Clin Endocrinol Metab 85:3276-82. 2000..in bone mass, body composition, and muscle strength with age are related to the fall in circulating endogenous testosterone (T) and estrogen concentrations...
- Testosterone administration impairs cognitive empathy in women depending on second-to-fourth digit ratioJack van Honk
Department of Experimental Psychology, Utrecht University, 3584 CS, Utrecht The Netherlands
Proc Natl Acad Sci U S A 108:3448-52. 2011..Females on average outperform males in this cognitive empathy, and the male sex hormone testosterone is thought to be involved...
- Clinical review: Endogenous testosterone and mortality in men: a systematic review and meta-analysisAndre B Araujo
Department of Epidemiology, New England Research Institutes, Inc, Watertown, Massachusetts 02472, USA
J Clin Endocrinol Metab 96:3007-19. 2011Low testosterone levels have been associated with outcomes that reduce survival in men.
- Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish menTina Kold Jensen
University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
Fertil Steril 82:863-70. 2004..To examine the relationship between body mass index (BMI) and semen quality among young men from the general population...
- Testosterone decreases trust in socially naive humansPeter A Bos
Department of Psychology, Utrecht University, 3584 CS, Utrecht, The Netherlands
Proc Natl Acad Sci U S A 107:9991-5. 2010..b>Testosterone, a steroid hormone associated with competition and dominance, is often viewed as an inhibitor of sociality, and ..
- Sex-specific associations between umbilical cord blood testosterone levels and language delay in early childhoodAndrew J O Whitehouse
Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, 100 Roberts Road, Subiaco, WA 6008, Australia
J Child Psychol Psychiatry 53:726-34. 2012Preliminary evidence suggests that prenatal testosterone exposure may be associated with language delay. However, no study has examined a large sample of children at multiple time-points.
- Dietary green and white teas suppress UDP-glucuronosyltransferase UGT2B17 mediated testosterone glucuronidationCarl Jenkinson
School of Life Sciences, Kingston University, London, UK
Steroids 77:691-5. 2012The anabolic steroid testosterone can be used by athletes to enhance athletic performance and muscle growth...
- Serum inhibin B in healthy pubertal and adolescent boys: relation to age, stage of puberty, and follicle-stimulating hormone, luteinizing hormone, testosterone, and estradiol levelsA M Andersson
Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
J Clin Endocrinol Metab 82:3976-81. 1997..In addition, serum levels of FSH, LH, testosterone, and estradiol levels were measured...
- The dark side of testosterone deficiency: II. Type 2 diabetes and insulin resistanceAbdulamaged M Traish
Department of Biochemistry and Urology, Boston University School of Medicine, Boston, MA 02118, USA
J Androl 30:23-32. 2009A considerable body of evidence exists suggesting a link among reduced testosterone plasma levels, type 2 diabetes (T2D), and insulin resistance (IR). Hypogonadal men are at higher risk for T2D...
- Increased incidence of diagnosed depressive illness in hypogonadal older menMolly M Shores
Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
Arch Gen Psychiatry 61:162-7. 2004Age-associated hypogonadism (testosterone deficit) occurs in 30% of men after the age of 55; it is associated with decreased muscle mass, bone mineral density, and libido, and with anorexia, fatigue, and irritability...
- Attentional, emotional and hormonal data in subjects of different agesGiuliano Fontani
Dipartimento di Fisiologia, Sezione di Neuroscienze e Fisiologia Applicata, Universita di Siena, Via A Moro 3, 53100, Siena, Italy
Eur J Appl Physiol 92:452-61. 2004..Emotionality was assessed on the basis of skin conductance, heart rate and frontalis muscle tone. Testosterone (T), free testosterone (fT), non-specifically bound testosterone (NST), sex hormone binding globulin (sHBG), ..
- Testosterone replacement therapy: current trends and future directionsE Nieschlag
Institute of Reproductive Medicine of the University Domagkstr 11, D 48129 Munster, Germany
Hum Reprod Update 10:409-19. 2004Male hypogonadism is characterized by abnormally low serum testosterone levels associated with typical symptoms, including mood disturbance, sexual dysfunction, decreased muscle mass and strength, and decreased bone mineral density...
- Protective effect of testosterone on early apoptotic damage induced by streptozotocin in rat pancreasS Morimoto
Instituto Nacional de Ciencias Medicas y Nutricion, SZ Vasco de Quiroga 15, Tlalpan 14000, D F Mexico, Mexico
J Endocrinol 187:217-24. 2005..present study was to investigate the early apoptotic damage induced by STZ in rat pancreas, and the effect of testosterone in preventing apoptosis of pancreatic beta cells...
- Fetal programming: prenatal testosterone treatment leads to follicular persistence/luteal defects; partial restoration of ovarian function by cyclic progesterone treatmentMohan Manikkam
Department of Pediatrics, University of Michigan, Ann Arbor, 48109 0404, USA
Endocrinology 147:1997-2007. 2006Prenatal testosterone (T) excess during midgestation leads to estrous cycle defects and polycystic ovaries in sheep...
- The relative contributions of aging, health, and lifestyle factors to serum testosterone decline in menThomas G Travison
New England Research Institutes, 9 Galen Street, Watertown, Massachusetts 02472, USA
J Clin Endocrinol Metab 92:549-55. 2007Although it is known that serum testosterone (T) concentrations decline with age, the relative contributions of changes in health and lifestyle to that decline have not been adequately assessed.
- A mixture of five phthalate esters inhibits fetal testicular testosterone production in the sprague-dawley rat in a cumulative, dose-additive mannerKembra L Howdeshell
Reproductive Toxicology Division, NHEERL, ORD, United States Environmental Protection Agency USEPA, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 105:153-65. 2008..benzylbutyl phthalate (BBP), di(n)butyl phthalate (DBP), and diethylhexyl phthalate (DEHP) decreases testicular testosterone production and insulin-like 3 hormone mRNA levels...
- Testosterone supplementation reverses sarcopenia in aging through regulation of myostatin, c-Jun NH2-terminal kinase, Notch, and Akt signaling pathwaysEkaterina L Kovacheva
Division of Endocrinology, Charles R Drew University, Los Angeles, California 90059, USA
Endocrinology 151:628-38. 2010Aging in rodents and humans is characterized by loss of muscle mass (sarcopenia). Testosterone supplementation increases muscle mass in healthy older men...
- Doping test results dependent on genotype of uridine diphospho-glucuronosyl transferase 2B17, the major enzyme for testosterone glucuronidationJenny Jakobsson Schulze
Clinical Pharmacology C1 68, Karolinska University Hospital, Huddinge, Stockholm, Sweden
J Clin Endocrinol Metab 93:2500-6. 2008b>Testosterone abuse is conventionally assessed by the urinary testosterone/epitestosterone (T/E) ratio, levels above 4.0 being considered suspicious...
- Testosterone and depression: systematic review and meta-analysisFahd Aziz Zarrouf
West Virginia University School of Medicine, Charleston Division, WV, USA
J Psychiatr Pract 15:289-305. 2009Studies suggest that testosterone (TT) replacement may have an antidepressant effect in depressed patients.
- Dysmetabolic syndrome in a man with a novel mutation of the aromatase gene: effects of testosterone, alendronate, and estradiol treatmentLaura Maffei
Consultorios Asociados de Endocrinologia, 1425 Buenos Aires, Argentina
J Clin Endocrinol Metab 89:61-70. 2004..The analysis of the effects induced by the successive treatment with high doses of testosterone, alendronate, and estradiol allows further insight into the roles of androgens and estrogens on several ..
- Reproductive effects in male rats exposed to diuronGlaura S A Fernandes
Departamento de Biologia Celular, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, Campinas, SP, Brazil
Reprod Toxicol 23:106-12. 2007..reproductive organ, liver and kidney weights; measurement of diuron concentrations in liver and kidney; plasma testosterone determinations; evaluation of daily sperm production per testis; sperm number and sperm transit time in the ..
- Insulin stimulates testosterone biosynthesis by human thecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction systemJ E Nestler
Department of Internal Medicine, Medical College of Virginia Virginia Commonwealth University, Richmond 23298, USA
J Clin Endocrinol Metab 83:2001-5. 1998To determine whether insulin stimulates human ovarian testosterone production in the polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system, thecal cells from ..
- Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human malesWaljit S Dhillo
Department of Metabolic Medicine, Faculty of Medicine, Imperial College London, London W12 ONN, United Kingdom
J Clin Endocrinol Metab 90:6609-15. 2005..The endogenous neuropeptide agonist for G protein-coupled receptor 54, kisspeptin, potently stimulates the hypothalamic-pituitary-gonadal axis in rodents and primates...
- Association of testosterone and sex hormone-binding globulin with metabolic syndrome and insulin resistance in menChaoyang Li
Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Diabetes Care 33:1618-24. 2010..We sought to assess the associations of testosterones and sex hormone-binding globulin (SHBG) with metabolic syndrome and insulin resistance in men...
- Effects of exogenous testosterone on the ventral striatal BOLD response during reward anticipation in healthy womenErno J Hermans
Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands
Neuroimage 52:277-83. 2010Correlational evidence in humans shows that levels of the androgen hormone testosterone are positively related to reinforcement sensitivity and competitive drive...
- Prevalence and incidence of androgen deficiency in middle-aged and older men: estimates from the Massachusetts Male Aging StudyAndre B Araujo
New England Research Institutes, Watertown, Massachusetts 02472, USA
J Clin Endocrinol Metab 89:5920-6. 2004..Data on androgen deficiency (defined using both signs/symptoms plus total and calculated free testosterone) were available for n = 1691 (baseline) and n = 1087 (follow-up) men from the Massachusetts Male Aging Study...
- Position statement: Utility, limitations, and pitfalls in measuring testosterone: an Endocrine Society position statementWilliam Rosner
St Luke s Roosevelt Hospital Center, 1000 Tenth Avenue, AJA 403, New York, New York 10019, USA
J Clin Endocrinol Metab 92:405-13. 2007The objective of the study was to evaluate the current state of clinical assays for total and free testosterone.
- Androgen receptor roles in spermatogenesis and fertility: lessons from testicular cell-specific androgen receptor knockout miceRuey Sheng Wang
Department of Pathology and Urology, George Whipple Laboratory for Cancer Research, University of Rochester Medical Center, Rochester, New York 14642, USA
Endocr Rev 30:119-32. 2009....
- Testosterone increases amygdala reactivity in middle-aged women to a young adulthood levelGuido A van Wingen
FC Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, The Netherlands
Neuropsychopharmacology 34:539-47. 2009b>Testosterone modulates mood and sexual function in women. However, androgen levels decline with age, which may relate to the age-associated change in sexual functioning and the prevalence of mood and anxiety disorders...
- TESTOSTERONE EFFECTS ON DIAPHRAGM MUSCLE FATIGUECesar Blanco; Fiscal Year: 2002DESCRIPTION (Adapted from the applicant's abstract): Anabolic-androgenic steroids (AAS), such as testosterone, are used to increase mass and strength...
- ANDROGEN AS ADJUNCT THERAPY IN RHEUMATOID ARTHRITISJohn Davis; Fiscal Year: 2002..A hypogonadic condition characterized by low serum testosterone has been previously described in male RA patients compared with age-matched controls with osteoarthritis, ..
- The Molecular Basis of Ovarian Testosterone ProductionRobert Rosenfield; Fiscal Year: 2004..and anovulation which appears to be due to dysregulation of steroidogenesis resulting in a high level of serum testosterone. Testosterone biosynthesis from androstenedione is carried out by androgenic 17b-hydroxysteroid dehydrogenase (..
- Xenoestrogen regulation of Leydig cellsBENSON TOKUNBO AKINGBEMI; Fiscal Year: 2010..Leydig cells are the predominant source of the male sex steroid hormone testosterone. Approximately 15% of infants fed soy-based formulas in the United States each year are exposed to the ..
- Yun Fai Chris Lau; Fiscal Year: 2014..Hence, the X-gene is a tumor suppressor gene. We show that these two sex chromosome genes can affect testosterone (male-hormone) associated physiology, again in opposing directions...
- Ashraf Gorgey; Fiscal Year: 2016..It is also unknown whether enhancing the decline anabolic homeostasis by providing testosterone (T) replacement therapy (TRT) would reverse body composition and metabolic profile changes in veterans with SCI...
- NICOLE RENEE TARTAGLIA; Fiscal Year: 2015..b>Testosterone deficiency develops during adolescence in the majority of affected males, but objective data about the ..
- A Soft Topical Antiandrogenic DrugWei Chu Xu; Fiscal Year: 2013..It is now widely recognized that testosterone (T) is an androgenic precursor of the more potent 5[unreadable]-dihydrotestosterone (DHT), produced by 5[..
- Epigenetics of Sex Differences in Brain and BehaviorBRIDGET NUGENT; Fiscal Year: 2012..that DNMT enzyme inhibition during the perinatal critical period will result in masculinized sex behavior in testosterone-primed adult female rats...
- John H Postlethwait; Fiscal Year: 2016..signal that promotes, in surrounding somatic cells, 3) the production of aromatase, the enzyme that 4) converts testosterone to estrogen, which preserves oocytes and biases the gonad toward a female fate;5) with insufficient quantities ..
- Gonadal Steroid Receptors and the Hypothalamo-Pituitary-Adrenal AxisRobert J Handa; Fiscal Year: 2013..is that sex differences in adult hormonal stress responses are primarily the result of the opposing actions of testosterone (T) and estrogen (E) on HPA function...
- Remote-control mouse-implantable micropumps for establishment of regenerative capJUAN GABRIEL contact SANTIAGO; Fiscal Year: 2010..then to identify effective temporal profiles for 5 other soluble regulators of MuSCs and their progeny (Wnt7a, testosterone, HGF, Wnt3a inhibitor, and MGF)...
- Sex Hormones in Postmenopausal Women in the Diabetes Prevention ProgramCatherine Kim; Fiscal Year: 2012..plasma stored from the baseline data collection and 2 years after randomization, we propose to examine ESH (testosterone, estradiol, sex hormone binding globulin) and follicle stimulating hormone (FSH) in a subset of DPP women ..
- Lucy A Waskell; Fiscal Year: 2014..This includes virtually all steroids (cholesterol, bile acids, estrogens, testosterone, cortisol, and vitamin D) and many lipids and eicosanoids...
- Henryk F Urbanski; Fiscal Year: 2014..In men, increasing age also results in significant perturbations in the levels of circulating androgens (testosterone and dehydroepiandrosterone (DHEA)), which has been linked to sarcopenia, osteoporosis, cardiovascular disease ..
- CRAIG STEPHEN ATWOOD; Fiscal Year: 2014..relevant sex steroids: women treated with E2 (3 controlled/1 uncontrolled studies) and men treated with testosterone (T;2 controlled studies), 3) the abrupt cognitive deficits observed in premenopausal women following '..
- DONNA LORRAINE WHITE; Fiscal Year: 2014..Experimental data suggests the AR and also its androgen ligands including the primary male sex hormone testosterone may play a role in increasing risk of liver cancer due to another viral infection, Hepatitis B virus...
- Mechanisms Regulating Reduced c-Kit-Dependent EAE Susceptibility in Male SJL MiceMELISSA ANN BROWN; Fiscal Year: 2013..This is not due to disparate serum testosterone levels between wild type and ckitW/Wv males, which show no significant differences...
- Melinda Sheffield-Moore; Fiscal Year: 2014..More recently, we found that 3 months of testosterone therapy downregulates ubiquitin and the E3 ubiquitin ligases MuRF1 and MAFbx/Atrogin-1 gene expression along ..
- Olfactory Circuits for Reproduction and RewardJames A Cherry; Fiscal Year: 2013..is differentially activated by male and female urinary volatiles in the two sexes and whether adult exposure to testosterone modulates the intensity of such responses...
- Kim Wallen; Fiscal Year: 2014..Current hormonal therapies for FSDD use treatment with an estrogen and testosterone, but their effectiveness is limited...
- Sex-Hormones and the TMPRSS2: ERG Fusion in Prostate Cancer ProgressionLorelei Mucci; Fiscal Year: 2013..whether obesity, with its known regulation of the hormonal milieu causing higher levels of estrogen and reduced testosterone, is associated with PCa progression by interacting with the TMPRSS2:ERG fusion...
- The Mechanism of Cryptorchidism in LH Receptor Knockout AnimalsZhenmin Lei; Fiscal Year: 2012..in mouse impaired development of adult-type Leydig cells which resulted in a dramatic reduction of INSL3 and testosterone levels. Surprisingly, serum estradiol levels were significantly increased...
- Regulation of Rhox5 Transcriptional ElongationMarcy E Richardson; Fiscal Year: 2013..subject of this proposal is the Rhox5 proximal promoter (Pp), which the Wilkinson laboratory showed depends on testosterone and androgen receptor (AR) for expression in Sertoli and caput epididymal cells...
- C Yan Cheng; Fiscal Year: 2016..TNF?, and transforming growth factor-?2/-3, TGF-?2 or -?3) have a disruptive effect on BTB integrity, whereas testosterone promotes BTB function, illustrating that the opposing effects of these molecules are crucial to maintain the ..
- The influence of selenium on biomarkers of prostate cancer riskKARAM E EL-BAYOUMY; Fiscal Year: 2012..biomarkers of risk PSA levels and testosterone metabolism, 3...
- LATRICE DOREEN FAULKNER; Fiscal Year: 2015..We will then castrate IR/LepRPOMC males and administer exogenous testosterone to evaluate their sensitivity to negative feedback...
- CYNTHIA LOUISE BETHEA; Fiscal Year: 2014..AR, and pivotal metabolic enzymes are localized in serotonin neurons and whether they are regulated by testosterone metabolites...
- Calcium Signaling in the Pubertal Activation of the GnRH Pulse GeneratorDaniel J Spergel; Fiscal Year: 2011..characterized by subtype with pharmacological antagonists, and compared in brain slices of gonadectomized and testosterone-clamped, as well as of gonadal-intact, male prepubertal, pubertal, and adult GnRH-GFP transgenic mice...
- Androgen Receptor-JunD Complex Inhibitors to Prevent Prostate Cancer ProgressionHirak S Basu; Fiscal Year: 2012..ROS levels are generally high in PCa cells as compared to their normal counterpart. Male hormone testosterone induces copious amounts of ROS generation specifically in PCa cells...
- Russ B Hauser; Fiscal Year: 2015..and BMI;3) altered serum concentrations of hormones that regulate somatic growth and pubertal development (testosterone, inhibin- B, MIS, LH, FSH, IGF-1, IGF-BP3, TSH and free T4);4) altered adult testis function, specifically ..
- Kassim Traore; Fiscal Year: 2014..litter size, and, later in life, Leydig cell hyperplasia, testicular atrophy, reduced serum levels of seru testosterone, and reduced fertility...
- GENDER DIFFERENCES IN STIMULANT ACTIONCynthia M Kuhn; Fiscal Year: 2012..In addition, we will determine if androgens like testosterone may exert the opposite effect to limit dopamine cell number, and so to limit cocaine-stimulated dopamine ..
- Delisa Fairweather; Fiscal Year: 2015..sera than women, that sex differences exist in anti-inflammatory complement receptor (CR)1 expression with testosterone reducing CR1/2 during coxsackievirus B3 (CVB3) myocarditis resulting in increased Th1, C3, CD11b/CR3 ..
- ELIZABETH AUSTEN LAWSON; Fiscal Year: 2015..AN is also associated with testosterone (T) deficiency, and preliminary data indicates that physiologic replacement leads to an increase in body mass ..
- Gender-Specific Role of p202 in Lupus SusceptibilityDivaker Choubey; Fiscal Year: 2010..of our proposed studies in the next funding period are to: (i) understand how sex hormones (estrogen and testosterone) differentially regulate the expression of Ifi202, a candidate lupus susceptibility gene (encoding p202 protein)..
- Oxymax System with Teadmill for Quantifying Exercise in MiceNeil B Ruderman; Fiscal Year: 2012..effects of exercise in mice with metabolic heart disease and myocardial dysfunction (Colucci)~ the ability of testosterone to enhance exercise performance in mice as they age (Bhasin and Jasuja)~ and the effects of overexpression and ..
- Adiposity and Outcomes of Clinically Localized Prostate CancerVincent L Freeman; Fiscal Year: 2013..adipose tissue-derived cytokines, eicosanoids products of arachidonic acid, and metabolites of estrogen and testosterone. Lifestyle factors that associate with more rapid progression of clinically early-stage prostate cancer are of ..
- REINA C VILLAREAL; Fiscal Year: 2014..Estrogen in males is mainly derived from the conversion of testosterone to estradiol by the enzyme aromatase...
- Participation in Cytochrome b5 in Anesthetic MetabolismLucy A Waskell; Fiscal Year: 2010..This includes virtually all steroids (cholesterol, bile acids, estrogens, testosterone, cortisol, and vitamin D) and many lipids and eicosanoids...
- Testosterone Replacement Therapy in Advanced Chronic Kidney DiseaseRalph Rabkin; Fiscal Year: 2009..In 2/3 of males with advanced CKD, serum testosterone (TT) levels are reduced and likely contribute to the wasting...
- Ruth I Wood; Fiscal Year: 2016..In 1991, testosterone was declared a controlled substance...
- Androgen Modulation of Neurodegeneration in Dopamine NeuronsRebecca L Cunningham; Fiscal Year: 2010..aged males, gonadally intact aged males, and gonadectomized aged males plus replacement androgen (testosterone or dihydrotestosterone) for either a chronic (3 months) or acute (1 week) treatment time length prior to 6-OHDA ..
- ERIC DOUGLAS AUSTIN; Fiscal Year: 2014..We hypothesize that estrogen-enhancing and testosterone-diminishing genotypes increase the risk of developing HPAH among BMPR2 mutation carriers...
- Regulation and Function of the Rhox5 Homeobox GeneMILES FROME WILKINSON; Fiscal Year: 2013..Because it is testosterone regulated and required for the normal fertility of male mice, studying Rhox5 has the potential to illuminate ..
- Sathish Kumar; Fiscal Year: 2016..As one of the common factors observed in these pregnancy pathologies, elevated maternal testosterone (T) is likely to contribute to the fetal programming of CV disorders...
- Wendy Saltzman; Fiscal Year: 2014..energetic (resting and maximal metabolic rates, daily energy expenditure), hormonal (corticosterone, testosterone), and behavioral (ingestive behavior, activity levels) measures...
- Kathryn M Rexrode; Fiscal Year: 2016..Specifically, we will test whether testosterone, estradiol, dehydroepiandrosterone sulfate (DHEAS), and sex hormone binding globulin (SHBG) might mediate ..
- Henryk F Urbanski; Fiscal Year: 2015DESCRIPTION (provided by applicant): In men and male rhesus macaques testosterone (T) and dehydroepiandrosterone (DHEA, an adrenal androgen precursor) show characteristic 24-hour patterns in the circulation, and both show significant age-..
- Equol and Regulation of Prostate GrowthRobert J Handa; Fiscal Year: 2011..gland pathology is evidenced by current therapies for these diseases, which include reduction in circulating testosterone;inhibition of 5-alpha reductase, an enzyme that synthesizes the potent androgen, dihydrotestosterone;or ..
- Genes Influencing Social BehaviorsDONALD WELLS PFAFF; Fiscal Year: 2010..as part of reproduction), compared to an 'affiliative behavior', maternal care compared to testosterone-facilitated aggression...
- Interactions of MAO A with vulnerability factors for aggressionMarco Bortolato; Fiscal Year: 2012..serotonin (5-HT), norepinephrine (NE) and dopamine (DA);male gender, in relation to the high levels of androgen testosterone and its metabolites...
- JASON LEE SPERRY; Fiscal Year: 2014..I hypothesize that estrogen will be associated with a protective effect while testosterone will be associated with poor outcome, as has been demonstrated repeatedly in the experimental animal literature...
- Maternal Androgen Excess: Vascular and Placental Function and Fetal ConsequencesKUNJU REDDIAR SATHISH KUMAR; Fiscal Year: 2012..Based on our preliminary data that testosterone does not cross placenta and the observation of vascular and placental defects in pregnant rats with elevated T, ..
- Hormonal and Paracrine Regulation of SpermatogenesisBarry R Zirkin; Fiscal Year: 2010..Naturally occurring ethnic differences in the response to testosterone (T)-based contraception will be studied to address this biological issue...
- MARA YVONNE ROTH; Fiscal Year: 2015..The specific aims of this proposal are: 1) to define the minimum intratesticular testosterone concentration necessary for spermatogenesis in men;2) to identify if variation in intratesticular hormone ..
- Sukhbir S Mokha; Fiscal Year: 2014..ORL1 agonists will be effective in adult men but their effectiveness may diminish in aging men as the levels of testosterone decline...
- Low birth weight, the kidney, and hypertensionBarbara T Alexander; Fiscal Year: 2013..Thus, we hypothesize that testosterone increases renal vascular resistance and exacerbates hypertension in male IUGR by enhancing the endothelin ..
- Structure and Function of Integral Membrane Enzyme Human AromataseDebashis Ghosh; Fiscal Year: 2012..determine the crystal structures of the complexes of P450arom with its (1) natural substrates androstenedione, testosterone, and 161-hydroxy-testosterone, as well as with (2) the inhibitors exemestane, letrozole, formestane, ..
- Matthew P Anderson; Fiscal Year: 2014..In males this period is identified by a testosterone surge that declines rapidly soon after birth...
- Xin Li; Fiscal Year: 2014..Hi-Myc mice will be treated with metformin, metformin plus rapamycin or vehicle for 12- and 24-weeks and MYC, testosterone (T), dihydrotestosterone (DHT), androgen receptor levels, proliferation, apoptosis indices and microvessel ..
- Sex/Gender Factors in Nicotine AddictionNancy K Mello; Fiscal Year: 2012..self-administration, and how acute and chronic treatment with neuroactive gonadal steroid hormones (estradiol, testosterone and progesterone) alters the reinforcing effects of nicotine...
- Wei Yan; Fiscal Year: 2014..provided by applicant): Leydig cells are interstitial cells of the testis and represent the major source of testosterone (T) production in men...
- Sex Steroids, and TMJ PainLarry Bellinger; Fiscal Year: 2009..Our central hypothesis is that changes in physiological estrogen, progesterone and testosterone concentrations modulates acute pain as modeled in the TMJ through action at peripheral tissue(s) within and ..
- Cardiovascular and Prostatic Safety of Testosterone Therapy in Aging MalesStephen K Van Den Eeden; Fiscal Year: 2013..libido, erectile dysfunction, fatigue and depression are found in conjunction with low levels of serum testosterone. Testosterone replacement therapy is a widespread and growing practice for treating androgen deficiency...
- Pubertal hyperandrogenemia, modification of day-night GnRH secretion, and PCOSChristopher R McCartney; Fiscal Year: 2012Project Summary/Abstract Polycystic ovary syndrome (PCOS) affects 6-8% of women and is marked by excess testosterone (T), irregular menses, and sub- or infertility...
- Role of 5-alpha Reductase in Testosterone ActionsShalendar Bhasin; Fiscal Year: 2007b>Testosterone, the predominant circulating androgen in men, also serves as a prohormone that is converted in the body to two active metabolites, estradiol 17beta and 5-alpha dihydrotestosterone (DHT)...
- TESTOSTERONE REPLACEMENT & PHYSICAL FUNCTION IN HIV+MENShalender Bhasin; Fiscal Year: 2005The role of testosterone as an anabolic agent is widely misunderstood and the mechanisms of its anabolic effects on the muscle are largely unknown...
- Mechanisms of Testosterone Effects on Body CompositionShalendar Bhasin; Fiscal Year: 2007b>Testosterone supplementation increases muscle mass and decreases fat mass in healthy young men, hypogonadal men, and in HTV-infected men with weight loss; these observations have prompted clinical trials of testosterone supplementation in ..
- Testosterone:Physical Function in Men on HemodialysisShalender Bhasin; Fiscal Year: 2004..b>Testosterone, when given in physiologic replacement doses, is an attractive anabolic intervention because it has been proven ..
- Prenatal Testosterone and Risk for Disordered Eating During PubertyKRISTEN CULBERT; Fiscal Year: 2009..Research suggests that prenatal testosterone may masculinize (i.e...
- Pem Homeobox Gene Function During SpermatogenesisJ Suzanne Lindsey; Fiscal Year: 2004..Communication between Sertoli cells of the testis and germ cells is essential for spermatogenesis. Testosterone regulates spermatogenesis through binding Sertoli cell androgen receptors and resultant gene transcription...
- ANDROGENS REGULATE IGF PATHWAY AND PROSTATE DISEASESJulianne Imperato McGinley; Fiscal Year: 2001..Androgens and IGFs interact to mutually potentiate their effects. Blocking conversion of testosterone to 5 alpha-dihydrotestosterone (DHT), inhibits prostatic IGF-I and IGF-I receptor gene expression while ..
- Allium Compounds in Control of Human Prostate CancerJOHN PINTO; Fiscal Year: 2003..in vitro, two events take place: (a) the proliferation rate of the LNCaP cells is markedly reduced and (b) testosterone concentration rapidly decreases in both the media in which the cells are growing as well as in the cells ..
- Nongenomic Androgen Signaling in Sertolli CellsWilliam H Walker; Fiscal Year: 2010The long-term goal of this project remains to determine the molecular and cellular mechanisms by which testosterone regulates spermatogenesis...
- Testosterone Therapy After Hip Fracture in Elderly WomenELLEN BINDER; Fiscal Year: 2005..The role of testosterone therapy for improving deficits in muscle mass, strength, and functional capacity in the frail elderly is ..
- REGULATION OF STEROIDOGENIC ENZYMES IN LEYDIG CELLSANITA PAYNE; Fiscal Year: 1993..of this project is to characterize the mechanisms that determine the capcity of Leydig cells to produce testosterone. We have approached this problem by studying the relationship of activities of steroid biosynthetic enzymes to ..
- MALE INFERTILITY AND ITS BIOLOGICAL BASISBarry Zirkin; Fiscal Year: 2002..Project I will examine the role of inadequate intratesticular testosterone concentration in human male infertility...
- METABOLISM & CONTROL OF TESTOSTERONE ANDROGENS IN MANRichard Horton; Fiscal Year: 1990..levels are reduced in androgen resistance and 5 alpha reductase deficiency cases in genetic males, and the testosterone/3 alpha diol glucuronide ratio is markedly altered...
- MOOD EFFECT OF TESTOSTERONE VS FLUOXETINE IN HIV ILLNESSJudith Rabkin; Fiscal Year: 2000..In this competitive continuation application, the primary goal is to evaluate the antidepressant effects of testosterone compared to fluoxetine in a double-blind randomized placebo controlled clinical trial for HIV-positive patients ..
- REGULATION OF SPERMATOGENESIS IN MAMMALSBarry Zirkin; Fiscal Year: 1991We propose to examine the quantitative response of specific spermatogenic cells to defined changes in testosterone concentration within the seminiferous tubules of the adult rat. Two specific aims are proposed...