dihydrotestosterone

Summary

Summary: A potent androgenic metabolite of TESTOSTERONE. Dihydrotestosterone (DHT) is generated by a 5-alpha reduction of testosterone. Unlike testosterone, DHT cannot be aromatized to ESTRADIOL therefore DHT is considered a pure androgenic steroid.

Top Publications

  1. ncbi Testosterone and dihydrotestosterone tissue levels in recurrent prostate cancer
    Mark A Titus
    Department of Pathology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, 27599 7295, USA
    Clin Cancer Res 11:4653-7. 2005
  2. ncbi The androgen axis in recurrent prostate cancer
    James L Mohler
    Department of Surgery, Division of Urology, Pathology and Laboratory Medicine, University of North Carolina Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
    Clin Cancer Res 10:440-8. 2004
  3. pmc Activation of the androgen receptor by intratumoral bioconversion of androstanediol to dihydrotestosterone in prostate cancer
    James L Mohler
    Department of Urology, Roswell Park Cancer Institute, Buffalo, New York, USA
    Cancer Res 71:1486-96. 2011
  4. ncbi A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy
    C W Gregory
    Laboratory for Reproductive Biology, Department of Pediatrics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Cancer Res 61:4315-9. 2001
  5. pmc Developmental time course of estradiol, testosterone, and dihydrotestosterone levels in discrete regions of male and female rat brain
    Anne T M Konkle
    Faculty of Health Sciences, Interdisciplinary School of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
    Endocrinology 152:223-35. 2011
  6. ncbi A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome
    Louise Mannerås
    Institute of Neuroscience and Physiology, Department of Physiology, Sahlgrenska Academy, Goteborg University, Box 434, SE 405 30 Goteborg, Sweden
    Endocrinology 148:3781-91. 2007
  7. pmc Dihydrotestosterone stimulates amino acid uptake and the expression of LAT2 in mouse skeletal muscle fibres through an ERK1/2-dependent mechanism
    M M Hamdi
    Biomedical and Clinical Sciences Research Institute, School of Medicine, Health Policy and Practice, University of East Anglia, Norwich NR4 7TJ, UK
    J Physiol 589:3623-40. 2011
  8. ncbi Effect of dihydrotestosterone on hydrogen peroxide-induced apoptosis of mouse embryonic stem cells
    Sang Hun Lee
    Department of Veterinary Physiology, BK21 Biotherapy Human Resources Center, College of Veterinary Medicine, Chonnam National University, Gwangju 500 757, Korea
    J Cell Physiol 216:269-75. 2008
  9. doi The effect of dihydrotestosterone exposure during or prior to the masculinization programming window on reproductive development in male and female rats
    A Dean
    MRC Centre for Reproductive Health, University of Edinburgh, The Queen s Medical Research Institute, Edinburgh, UK
    Int J Androl 35:330-9. 2012
  10. ncbi Development of a quantitative RT-PCR method to study 5alpha-reductase mRNA isozymes in rat prostate in different androgen status
    Jesus M Torres
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Granada, Granada, Spain
    Prostate 56:74-9. 2003

Research Grants

  1. Role of 5-alpha Reductase in Testosterone Actions
    Shalendar Bhasin; Fiscal Year: 2007
  2. ALTERED METABOLISM AND CARCINOGENESIS BY DES
    CORAL LAMARTINIERE; Fiscal Year: 1990
  3. Androgen Modulation of Neurodegeneration in Dopamine Neurons
    Rebecca L Cunningham; Fiscal Year: 2009
  4. Androgen Modulation of Neurodegeneration in Dopamine Neurons
    Rebecca L Cunningham; Fiscal Year: 2010
  5. PROGESTERONE RECEPTOR AND ACTION IN THE PRIMATE OVARY
    Richard Stouffer; Fiscal Year: 2007
  6. PROGESTERONE RECEPTOR AND ACTION IN THE PRIMATE OVARY
    Richard Stouffer; Fiscal Year: 2009
  7. PROGESTERONE RECEPTOR AND ACTION IN THE PRIMATE OVARY
    Richard L Stouffer; Fiscal Year: 2010
  8. PROGESTERONE RECEPTOR AND ACTION IN THE PRIMATE OVARY
    Richard Stouffer; Fiscal Year: 2006
  9. Role of 5-alpha Reductase in Testosterone Actions
    Shalender Bhasin; Fiscal Year: 2004
  10. Role of 5-alpha Reductase in Testosterone Actions
    Shalender Bhasin; Fiscal Year: 2006

Detail Information

Publications257 found, 100 shown here

  1. ncbi Testosterone and dihydrotestosterone tissue levels in recurrent prostate cancer
    Mark A Titus
    Department of Pathology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, 27599 7295, USA
    Clin Cancer Res 11:4653-7. 2005
    ..Many groups have pursued mechanisms of ligand-independent androgen receptor activation but we found high levels of testicular androgens in recurrent prostate cancer tissue using RIA...
  2. ncbi The androgen axis in recurrent prostate cancer
    James L Mohler
    Department of Surgery, Division of Urology, Pathology and Laboratory Medicine, University of North Carolina Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
    Clin Cancer Res 10:440-8. 2004
    ..High levels of expression of androgen receptor and androgen receptor-regulated genes in recurrent prostate cancer suggest a role for androgen receptor and its ligands in prostate cancer recurrence...
  3. pmc Activation of the androgen receptor by intratumoral bioconversion of androstanediol to dihydrotestosterone in prostate cancer
    James L Mohler
    Department of Urology, Roswell Park Cancer Institute, Buffalo, New York, USA
    Cancer Res 71:1486-96. 2011
    The androgen receptor (AR) mediates the growth of benign and malignant prostate in response to dihydrotestosterone (DHT)...
  4. ncbi A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy
    C W Gregory
    Laboratory for Reproductive Biology, Department of Pediatrics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Cancer Res 61:4315-9. 2001
    ..development and growth of prostate cancer depends on the androgen receptor and its high-affinity binding of dihydrotestosterone, which derives from testosterone...
  5. pmc Developmental time course of estradiol, testosterone, and dihydrotestosterone levels in discrete regions of male and female rat brain
    Anne T M Konkle
    Faculty of Health Sciences, Interdisciplinary School of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
    Endocrinology 152:223-35. 2011
    ..profile of steroids in the rat brain using RIA to quantify the level of estradiol, testosterone, and dihydrotestosterone in discrete subregions of the brain from embryonic d 19 to adulthood...
  6. ncbi A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome
    Louise Mannerås
    Institute of Neuroscience and Physiology, Department of Physiology, Sahlgrenska Academy, Goteborg University, Box 434, SE 405 30 Goteborg, Sweden
    Endocrinology 148:3781-91. 2007
    ..Female rats received the nonaromatizable androgen dihydrotestosterone (DHT) or the aromatase inhibitor letrozole by continuous administration, beginning before puberty, to ..
  7. pmc Dihydrotestosterone stimulates amino acid uptake and the expression of LAT2 in mouse skeletal muscle fibres through an ERK1/2-dependent mechanism
    M M Hamdi
    Biomedical and Clinical Sciences Research Institute, School of Medicine, Health Policy and Practice, University of East Anglia, Norwich NR4 7TJ, UK
    J Physiol 589:3623-40. 2011
    b>Dihydrotestosterone (DHT) has acute/non-genomic actions in adult mammalian skeletal muscles whose physiological functions are still poorly understood...
  8. ncbi Effect of dihydrotestosterone on hydrogen peroxide-induced apoptosis of mouse embryonic stem cells
    Sang Hun Lee
    Department of Veterinary Physiology, BK21 Biotherapy Human Resources Center, College of Veterinary Medicine, Chonnam National University, Gwangju 500 757, Korea
    J Cell Physiol 216:269-75. 2008
    ..Therefore, using mouse embryonic stem (ES) cells as a model system, this study evaluated the effects of dihydrotestosterone (DHT), a biologically active testosterone metabolite, on H2O2-induced apoptosis...
  9. doi The effect of dihydrotestosterone exposure during or prior to the masculinization programming window on reproductive development in male and female rats
    A Dean
    MRC Centre for Reproductive Health, University of Edinburgh, The Queen s Medical Research Institute, Edinburgh, UK
    Int J Androl 35:330-9. 2012
    ..masculinization could be advanced or enhanced by treating pregnant rats with either 1 or 10 mg/kg/day dihydrotestosterone (DHT) prior to (early window, EW; e11.5-e14.5) or during the MPW (e15.5-e18...
  10. ncbi Development of a quantitative RT-PCR method to study 5alpha-reductase mRNA isozymes in rat prostate in different androgen status
    Jesus M Torres
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Granada, Granada, Spain
    Prostate 56:74-9. 2003
    ..The development and growth of the prostate gland depends on androgen stimulation. Dihydrotestosterone (DHT) is the primary androgen responsible for prostate development and also for the pathogenesis of benign ..
  11. ncbi Prostate cancer stromal cells and LNCaP cells coordinately activate the androgen receptor through synthesis of testosterone and dihydrotestosterone from dehydroepiandrosterone
    Atsushi Mizokami
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Sciences, Takaramachi, Kanazawa City, Japan
    Endocr Relat Cancer 16:1139-55. 2009
    ..Biosynthesis of testosterone or dihydrotestosterone from DHEA in stromal cells and LNCaP cells was involved in this stimulation of LNCaP cell proliferation...
  12. ncbi Postnatal testosterone exposure results in insulin resistance, enlarged mesenteric adipocytes, and an atherogenic lipid profile in adult female rats: comparisons with estradiol and dihydrotestosterone
    Camilla Alexanderson
    Institute of Neuroscience and Physiology, Department of Physiology Endocrinology, Sahlgrenska Academy, Goteborg University, Box 434, 405 30, Goteborg, Sweden
    Endocrinology 148:5369-76. 2007
    ..in these programming effects, we compared testosterone-exposed rats to rats exposed to estradiol or dihydrotestosterone (DHT)...
  13. pmc Stereo-selective inhibition of transient receptor potential TRPC5 cation channels by neuroactive steroids
    Y Majeed
    Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, UK
    Br J Pharmacol 162:1509-20. 2011
    ..Steroids are known to modulate fear and anxiety states, and we therefore investigated whether TRPC5 exhibited sensitivity to steroids...
  14. doi Endothelial regulation of eNOS, PAI-1 and t-PA by testosterone and dihydrotestosterone in vitro and in vivo
    L Goglia
    Department of Reproductive Medicine and Child Development, Molecular and Cellular Gynecological Endocrinology Laboratory MCGEL, University of Pisa, Pisa, Italy
    Mol Hum Reprod 16:761-9. 2010
    ..of this study is the identification of direct endothelial regulation by the androgens testosterone (T) and dihydrotestosterone (DHT)...
  15. ncbi The androgen 5alpha-dihydrotestosterone and its metabolite 5alpha-androstan-3beta, 17beta-diol inhibit the hypothalamo-pituitary-adrenal response to stress by acting through estrogen receptor beta-expressing neurons in the hypothalamus
    Trent D Lund
    Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    J Neurosci 26:1448-56. 2006
    ..action on these neurons, we examined the effects of central implants of 17beta-estradiol (E2), 5alpha-dihydrotestosterone (DHT), the DHT metabolite 5alpha-androstan-3beta, 17beta-diol (3beta-diol), and several ER subtype-..
  16. pmc Tissue culture media supplemented with 10% fetal calf serum contains a castrate level of testosterone
    J P Michiel Sedelaar
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, School of Medicine, Baltimore, MD 21231, USA
    Prostate 69:1724-9. 2009
    ..e., DC-FCS) is often used instead of FCS to minimize the level of androgen provided in 10% serum supplemented media. Therefore, total and free testosterone levels in 10%DC-FCS containing media were likewise determined...
  17. ncbi The influence of androgen deprivation therapy on dihydrotestosterone levels in the prostatic tissue of patients with prostate cancer
    Tsutomu Nishiyama
    Division of Urology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan nisiyamamed niigata u ac jp
    Clin Cancer Res 10:7121-6. 2004
    The influence of androgen deprivation therapy on dihydrotestosterone levels in the prostatic tissue is not clearly known...
  18. ncbi Pharmacologic basis for the enhanced efficacy of dutasteride against prostatic cancers
    Yi Xu
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Clin Cancer Res 12:4072-9. 2006
    Prostatic dihydrotestosterone (DHT) concentration is regulated by precursors from systemic circulation and prostatic enzymes of androgen metabolism, particularly 5alpha-reductases (i.e., SRD5A1 and SRD5A2)...
  19. ncbi Testosterone and dihydrotestosterone, but not estradiol, enhance survival of new hippocampal neurons in adult male rats
    Mark D Spritzer
    Department of Psychology, The University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
    Dev Neurobiol 67:1321-33. 2007
    ..We next tested the role of testosterone's two major metabolites, dihydrotestosterone (DHT), and estradiol, upon neurogenesis. Thirty days of injections of DHT (0.25 and 0...
  20. doi Low-frequency electro-acupuncture and physical exercise improve metabolic disturbances and modulate gene expression in adipose tissue in rats with dihydrotestosterone-induced polycystic ovary syndrome
    Louise Mannerås
    Institute of Neuroscience and Physiology, Department of Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Endocrinology 149:3559-68. 2008
    ..b>Dihydrotestosterone (inducing PCOS) or vehicle (control) was administrated continuously, beginning before puberty...
  21. ncbi 17beta-hydroxysteroid dehydrogenase type 1 stimulates breast cancer by dihydrotestosterone inactivation in addition to estradiol production
    Juliette A Aka
    Research Center of the Laval University Hospital Center CHUQ CHUL and Laval University, Quebec, Canada
    Mol Endocrinol 24:832-45. 2010
    The active estrogen estradiol (E2) stimulates breast cancer cell (BCC) growth, whereas the androgen dihydrotestosterone (DHT) has shown an antiproliferative effect...
  22. doi Sex differences in brain and plasma beta-endorphin content following testosterone, dihydrotestosterone and estradiol administration to gonadectomized rats
    Nicola Pluchino
    Department of Reproductive Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Neuroendocrinology 89:411-23. 2009
    The present study aims at evaluating the effect of a 2-week treatment with testosterone (T), dihydrotestosterone (DHT) and estradiol valerate (E(2)V) on brain and plasma beta-endorphin (beta-END) concentrations in gonadectomized rats of ..
  23. ncbi Dihydrotestosterone and the prostate: the scientific rationale for 5alpha-reductase inhibitors in the treatment of benign prostatic hyperplasia
    Gerald Andriole
    Division of Urological Surgery, Washington University in St Louis, St Louis, Missouri 63110, USA
    J Urol 172:1399-403. 2004
    We reviewed the physiological and pathogenic role of dihydrotestosterone (DHT), evidence for the beneficial effects of decreasing DHT through 5alpha-reductase inhibition and the effects of altering the androgen balance with these agents.
  24. ncbi Organizational effects of testosterone, estradiol, and dihydrotestosterone on vasopressin mRNA expression in the bed nucleus of the stria terminalis
    Tina M Han
    Center for Neuroendocrine Studies, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Neurobiol 54:502-10. 2003
    ..We then sought to determine the effects of testosterone metabolites, estradiol and dihydrotestosterone, given alone or in combination, on AVP expression in the BST...
  25. pmc Developmental programming: differential effects of prenatal testosterone and dihydrotestosterone on follicular recruitment, depletion of follicular reserve, and ovarian morphology in sheep
    Peter Smith
    AgResearch Wallaceville, Upper Hutt, New Zealand
    Biol Reprod 80:726-36. 2009
    ..Pregnant sheep were given twice-weekly injections of testosterone or dihydrotestosterone (DHT), a nonaromatizable androgen, from Days 30 to 90 of gestation...
  26. doi Dihydrotestosterone suppresses foam cell formation and attenuates atherosclerosis development
    Yang Qiu
    Department of Medicine and Bioregulatory Science, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Endocrinology 151:3307-16. 2010
    ..We investigated the effect of the nonaromatized natural androgen 5alpha-dihydrotestosterone (DHT) on the rabbit atherogenesis in relation to the proatherogenic molecule lectin-like oxidized-low-..
  27. pmc Thrombospondin-1 regulates the normal prostate in vivo through angiogenesis and TGF-beta activation
    Philip P Fitchev
    Department of Surgery, NorthShore University HealthSystem Research Institute, Evanston, IL 60201, USA
    Lab Invest 90:1078-90. 2010
    ..Therefore, loss of TSP-1 during tumorigenesis would eliminate two barriers to cancer progression...
  28. doi Dihydrotestosterone protects human vascular endothelial cells from H(2)O(2)-induced apoptosis through inhibition of caspase-3, caspase-9 and p38 MAPK
    Zhe rong Xu
    Department of Geriatrics, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    Eur J Pharmacol 643:254-9. 2010
    ..This study was designed to investigate the protective effect and potential mechanisms of dihydrotestosterone (DHT) against H(2)O(2)-induced apoptosis of human umbilical vein endothelial cells (ECV-304)...
  29. pmc Androgen-dependent regulation of human MUC1 mucin expression
    Stephen Mitchell
    Department of Histopathology, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK
    Neoplasia 4:9-18. 2002
    ..This is also functionally associated with decreased cell-cell adhesion, a recognised feature of progressive malignancy. These findings have important implications for physiological and pathological processes...
  30. ncbi Dihydrotestosterone interacts with EGFR/MAPK signalling and modulates EGFR levels in androgen receptor-positive LNCaP prostate cancer cells
    Biswajit Mukherjee
    Hormones and Signal Transduction Group, German Cancer Research Centre, D 69120 Heidelberg, Germany
    Int J Oncol 33:623-9. 2008
    ..We found that 5alpha-dihydrotestosterone (DHT) and EGF had a synergistic effect on AR activity as detected by a luciferase reporter system, although ..
  31. pmc Mild exercise increases dihydrotestosterone in hippocampus providing evidence for androgenic mediation of neurogenesis
    Masahiro Okamoto
    Laboratory of Exercise Biochemistry and Neuroendocrinology, Faculty of Health and Sports Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8574, Japan
    Proc Natl Acad Sci U S A 109:13100-5. 2012
    ..A mass-spectrometric analysis demonstrated that hippocampal dihydrotestosterone increased significantly, whereas testosterone levels did not increase significantly after 2 wk of treadmill ..
  32. pmc Estrogen receptor β and 17β-hydroxysteroid dehydrogenase type 6, a growth regulatory pathway that is lost in prostate cancer
    Selvaraj Muthusamy
    Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX 77204, USA
    Proc Natl Acad Sci U S A 108:20090-4. 2011
    ..The proliferative action of the androgen receptor is activated by 5α-dihydrotestosterone (DHT). Thus, prostate growth is governed by the balance between androgen receptor and ERβ activation...
  33. pmc Isoflavone supplements stimulated the production of serum equol and decreased the serum dihydrotestosterone levels in healthy male volunteers
    M Tanaka
    Department of Urology, Nara Medical University, Kashihara, Japan
    Prostate Cancer Prostatic Dis 12:247-52. 2009
    ..of sex hormone-binding globulin significantly increased, and the serum levels of free testosterone and dihydrotestosterone (DHT) decreased significantly after 3-month supplementation...
  34. doi Electrical and manual acupuncture stimulation affect oestrous cyclicity and neuroendocrine function in an 5α-dihydrotestosterone-induced rat polycystic ovary syndrome model
    Yi Feng
    Institute of Neuroscience and Physiology, Department of Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden
    Exp Physiol 97:651-62. 2012
    ..than manual stimulation in regulating disturbed oestrous cyclicity in rats with PCOS induced by 5α-dihydrotestosterone. To identify the central mechanisms of the effects of stimulation, we assessed hypothalamic mRNA expression ..
  35. doi Serum testosterone, dihydrotestosterone and estradiol concentrations in older men self-reporting very good health: the healthy man study
    Gideon Sartorius
    Andrology Department, Concord Hospital, Clayton, Vic, Australia
    Clin Endocrinol (Oxf) 77:755-63. 2012
    To determine serum concentrations, intra-individual variability and impact of age-related co-morbidities on serum testosterone (T), dihydrotestosterone (DHT), estradiol (E(2)) and estrone (E(1)) in older men.
  36. pmc Reexamination of testosterone, dihydrotestosterone, estradiol and estrone levels across the menstrual cycle and in postmenopausal women measured by liquid chromatography-tandem mass spectrometry
    Micol S Rothman
    Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    Steroids 76:177-82. 2011
    ..liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays to determine testosterone (T) and dihydrotestosterone (DHT) along with estradiol (E2) and estrone (E1) levels across the menstrual cycle of 31 healthy ..
  37. pmc Prenatal testosterone and dihydrotestosterone exposure disrupts ovine testicular development
    Charles L Bormann
    Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Reproduction 142:167-73. 2011
    ..The objectives of this study were to determine the effects of prenatal 5α-dihydrotestosterone (DHT) and testosterone treatment during ovine sexual differentiation on post-pubertal testicular formation ..
  38. pmc Estradiol induction of spermatogenesis is mediated via an estrogen receptor-{alpha} mechanism involving neuroendocrine activation of follicle-stimulating hormone secretion
    Charles M Allan
    ANZAC Research Institute, Sydney, New South Wales 2139, Australia
    Endocrinology 151:2800-10. 2010
    Both testosterone and its nonaromatizable metabolite dihydrotestosterone (DHT) induce spermatogenesis in gonadotropin-deficient hpg mice...
  39. pmc Modulation of androgen receptor activation function 2 by testosterone and dihydrotestosterone
    Emily B Askew
    Curriculum in Toxicology, Laboratories for Reproductive Biology, Lineberger Comprehensive Cancer Center, Department of Pediatrics, University of North Carolina, Chapel Hill 27599, USA
    J Biol Chem 282:25801-16. 2007
    ..transcriptionally activated by high affinity binding of testosterone (T) or its 5alpha-reduced metabolite, dihydrotestosterone (DHT), a more potent androgen required for male reproductive tract development...
  40. pmc The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men
    Kishore M Lakshman
    Division of Endocrinology, Diabetes and Nutrition, Boston Claude D Pepper Older Americans Independence Center for Function Promoting Therapies, Boston University School of Medicine, Boston Medical Center, 670 Albany Street, Second Floor, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 95:3955-64. 2010
    During testosterone (T) therapy, T is partly converted to 17beta-estradiol (E2) and 5alpha-dihydrotestosterone (DHT). Effects of age, testosterone dose, and body composition on total and free E2 and DHT levels are unknown.
  41. doi Rapid membrane responses to dihydrotestosterone are sex dependent in growth plate chondrocytes
    Khairat Elbaradie
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, United States
    J Steroid Biochem Mol Biol 132:15-23. 2012
    ..female rat growth plate chondrocytes convert testosterone to 17β-estradiol, male chondrocytes produce 5α-dihydrotestosterone (DHT)...
  42. pmc Androgen decreases dopamine neurone survival in rat midbrain
    M L Johnson
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA
    J Neuroendocrinol 22:238-47. 2010
    ..Replacement with testosterone or the non-aromatisable analogue dihydrotestosterone (DHT) in castrated animals reduced TH-IR cell number in the SNpc and VTA in rats...
  43. ncbi Steroid 5alpha-reductase isozymes in the adult female rat brain: central role of dihydrotestosterone
    J M Torres
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Granada, Avda de Madrid s n, 18012 Granada, Spain
    J Mol Endocrinol 36:239-45. 2006
    ..In this work, we studied the effects of testosterone (T) and dihydrotestosterone (DHT) on mRNA levels of both 5alpha-R isoforms in the prefrontal cortex of the adult female rat by one-step ..
  44. ncbi Sexual dimorphism of growth plate prehypertrophic and hypertrophic chondrocytes in response to testosterone requires metabolism to dihydrotestosterone (DHT) by steroid 5-alpha reductase type 1
    P Raz
    Hebrew University Hadassah, Jerusalem, Israel
    J Cell Biochem 95:108-19. 2005
    ..response of rat costochondral cartilage cells to testosterone requires further metabolism of the hormone to dihydrotestosterone (DHT)...
  45. doi Activation of PKR/eIF2α signaling cascade is associated with dihydrotestosterone-induced cell cycle arrest and apoptosis in human liver cells
    Rongyang Dai
    Department of Biochemistry of Luzhou Medical College, Luzhou, Sichuan, China
    J Cell Biochem 113:1800-8. 2012
    ..b>Dihydrotestosterone (DHT) is the active metabolite of the major circulating androgen, testosterone...
  46. ncbi Androgens and estrogens induce seasonal-like growth of song nuclei in the adult songbird brain
    Anthony D Tramontin
    Department of Neurosurgery Research, University of California, San Francisco, California 94143, USA
    J Neurobiol 57:130-40. 2003
    ..regressed song control nuclei were implanted with silastic capsules containing either crystalline T, 5alpha-dihydrotestosterone (DHT), estradiol (E(2)), or a combination of DHT+E(2). Control animals received empty implants...
  47. ncbi Androgen receptor signaling induced by supraphysiological doses of dihydrotestosterone in human peripheral blood lymphocytes
    Esther Imperlini
    Fondazione SDN IRCCS, Napoli, Italy
    Proteomics 10:3165-75. 2010
    ..Testosterone, the main male sexual hormone, binds AR directly and indirectly, through conversion into dihydrotestosterone (DHT), its more active metabolite...
  48. pmc Nuclear compartmentalization of N-CoR and its interactions with steroid receptors
    Yin Wu
    Department of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Mol Cell Biol 26:6633-55. 2006
    ..In fluorescence recovery after photobleaching analysis, mobility of the N-CoR was reduced by 5alpha-dihydrotestosterone (DHT)-bound AR...
  49. ncbi Upregulation of prostate specific membrane antigen/folate hydrolase transcription by an enhancer
    Kenneth R Noss
    Research Service 151, Overton Brooks Veterans Administration Medical Center, Shreveport, LA 71101 4295, USA
    Gene 285:247-56. 2002
    ..These results demonstrate significant upregulation of transcription by the PSMA promoter/enhancer, with specificity for the LNCaP prostate cell line, and downregulation of transcription in response to physiological levels of androgen...
  50. ncbi Role of androgens on MCF-7 breast cancer cell growth and on the inhibitory effect of letrozole
    Luciana F Macedo
    Department of Pharmacology and Experimental Therapeutics, University of Maryland, 685 West Baltimore Street, Baltimore, MD 21201, USA
    Cancer Res 66:7775-82. 2006
    ..Here, we report that androgens, such as the aromatizable androstenedione and the non-aromatizable 5alpha-dihydrotestosterone, inhibit MCF-7 cell proliferation...
  51. doi A novel spreadsheet method for calculating the free serum concentrations of testosterone, dihydrotestosterone, estradiol, estrone and cortisol: with illustrative examples from male and female populations
    Norman A Mazer
    Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston, MA, United States
    Steroids 74:512-9. 2009
    In humans, testosterone (T), dihydrotestosterone (DHT), estradiol (E2), estrone (E1) and cortisol (C) bind to the serum proteins sex hormone-binding globulin (SHBG), albumin (Alb) and corticosteroid-binding globulin (CBG)...
  52. ncbi Lack of effect of testosterone and dihydrotestosterone compared to 17beta-oestradiol in 1-methyl-4-phenyl-1,2,3,6, tetrahydropyridine-mice
    A Ekue
    Molecular Endocrinology and Oncology Research Center, Laval University Medical Center, CHUL and Faculty of Pharmacy, Laval University, Quebec, Canada
    J Neuroendocrinol 14:731-6. 2002
    ..The effects of 17beta-oestradiol (2 microg/day), testosterone (100 microg/day) and dihydrotestosterone (DHT) (2 microg/day or 100 microg/day) were studied during 5 days before and after an acute treatment of ..
  53. ncbi The role of 5alpha-reduction in steroid hormone physiology
    J D Wilson
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75390 8857, USA
    Reprod Fertil Dev 13:673-8. 2001
    A role for 5alpha-reduction in androgen physiology was first established with the recognition that dihydrotestosterone, the 5alpha-reduced metabolite of testosterone, is formed in many androgen target tissues, binds to the androgen ..
  54. ncbi Estrogen receptor-beta mediates dihydrotestosterone-induced stimulation of the arginine vasopressin promoter in neuronal cells
    Toni R Pak
    Department of Biomedical Science, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523, USA
    Endocrinology 148:3371-82. 2007
    ..However, 5alpha-dihydrotestosterone (DHT) has also been shown to play a role in the regulation of AVP expression, thus implicating the ..
  55. pmc Potential prostate cancer drug target: bioactivation of androstanediol by conversion to dihydrotestosterone
    James L Mohler
    Department of Urology, Roswell Park Cancer Institute, Department of Urology, University at Buffalo, State University of New York, Buffalo, New York, USA
    Clin Cancer Res 17:5844-9. 2011
    High-affinity binding of dihydrotestosterone (DHT) to the androgen receptor (AR) initiates androgen-dependent gene activation, required for normal male sex development in utero, and contributes to prostate cancer development and ..
  56. pmc Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer
    Kai Hsiung Chang
    Division of Hematology and Oncology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8852, USA
    Proc Natl Acad Sci U S A 108:13728-33. 2011
    ..The development of CRPC is dependent upon the intratumoral generation of the potent androgen, dihydrotestosterone (DHT), from adrenal precursor steroids...
  57. doi A novel ultrapressure liquid chromatography tandem mass spectrometry method for the simultaneous determination of androstenedione, testosterone, and dihydrotestosterone in pediatric blood samples: age- and sex-specific reference data
    A E Kulle
    Department of Pediatrics, Christian Albrechts University of Kiel, 24105 Kiel, Germany
    J Clin Endocrinol Metab 95:2399-409. 2010
    ..Mass spectrometry-based methods are available for individual steroids but need complex sample preparation and report only fragmentary reference data for the pediatric population...
  58. pmc Androgen treatment and muscle strength in elderly men: A meta-analysis
    Kenneth J Ottenbacher
    Division of Rehabilitation Sciences, Sealy Center on Aging, Houston, Texas, USA
    J Am Geriatr Soc 54:1666-73. 2006
    ..To review published, randomized trials examining the effect of androgen treatment on muscle strength in older men...
  59. ncbi Persistent intraprostatic androgen concentrations after medical castration in healthy men
    Stephanie T Page
    University of Washington Medical Center, Division of Metabolism, Endocrinology and Nutrition, Box 357138, 1959 NE Pacific, Seattle, WA 98195
    J Clin Endocrinol Metab 91:3850-6. 2006
    ..Studies of men with prostate cancer have suggested that prostatic androgens are preserved in the setting of castration. Tissue androgens might stimulate prostate growth, producing adverse clinical consequences...
  60. ncbi p66Shc protein is upregulated by steroid hormones in hormone-sensitive cancer cells and in primary prostate carcinomas
    Ming Shyue Lee
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Int J Cancer 108:672-8. 2004
    ..05). The data collectively indicate that p66(Shc) protein levels correlate with steroid hormone-stimulated cell growth and prostate carcinogenesis...
  61. ncbi Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells
    Tea Lanisnik Rizner
    Department of Pharmacology, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Endocrinology 144:2922-32. 2003
    ..adenine dinucleotide (NAD(+))-dependent oxidation of 3alpha-androstanediol (3alpha-diol) to 5alpha-dihydrotestosterone (5alpha-DHT)...
  62. ncbi Differential regulation of steroid 5alpha-reductase isozymes expression by androgens in the adult rat brain
    J M Torres
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Granada, Avda de Madrid s n, 18012 Granada, Spain
    FASEB J 17:1428-33. 2003
    ..of 5alpha-R in the brain derives from its capability to convert testosterone (T) to a more potent androgen, dihydrotestosterone (DHT), and to convert progesterone and deoxycorticosterone (DOC) to their respective 5alpha-reduced ..
  63. pmc Activated androgen receptor downregulates E-cadherin gene expression and promotes tumor metastasis
    Yan Nian Liu
    Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan
    Mol Cell Biol 28:7096-108. 2008
    ..Treating cells with the AR ligand, dihydrotestosterone (DHT), triggered the reduction of E-cadherin expression and induced changes in cell morphology from an ..
  64. doi Androgen biosynthetic pathways in the human prostate
    Van Luu-The
    Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center, Laval University, Quebec, Canada
    Best Pract Res Clin Endocrinol Metab 22:207-21. 2008
    It is well recognized that there are two androgens, namely testosterone (T) and dihydrotestosterone (DHT); T plays an important role in the testis and muscle, and DHT is crucial for the development, function and pathology of the prostate...
  65. ncbi Marked suppression of dihydrotestosterone in men with benign prostatic hyperplasia by dutasteride, a dual 5alpha-reductase inhibitor
    Richard V Clark
    Clinical Pharmacology, GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina 27709, USA
    J Clin Endocrinol Metab 89:2179-84. 2004
    b>Dihydrotestosterone (DHT) is the primary metabolite of testosterone in the prostate and skin. Testosterone is converted to DHT by 5alpha-reductase, which exists in two isoenzyme forms (types 1 and 2)...
  66. doi Dihydrotestosterone and leptin regulate gonadotropin-releasing hormone (GnRH) expression and secretion in human GnRH-secreting neuroblasts
    Annamaria Morelli
    Andrology Unit, Department of Clinical Physiotherapy, University of Florence, Florence, Italy
    J Sex Med 6:397-407. 2009
    ....
  67. pmc Multiple steps determine the overall rate of the reduction of 5alpha-dihydrotestosterone catalyzed by human type 3 3alpha-hydroxysteroid dehydrogenase: implications for the elimination of androgens
    Yi Jin
    Center of Excellence in Environmental Toxicology, Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6084, USA
    Biochemistry 45:13054-63. 2006
    ..or aldo-keto reductase (AKR) 1C2, eliminates the androgen signal in human prostate by reducing 5alpha-dihydrotestosterone (DHT, potent androgen) to form 3alpha-androstanediol (inactive androgen), thereby depriving the androgen ..
  68. ncbi Androgens activate mitogen-activated protein kinase signaling: role in neuroprotection
    Thuy Vi V Nguyen
    Neuroscience Graduate Program, University of Southern California, Los Angeles, California 90089 0191, USA
    J Neurochem 94:1639-51. 2005
    ..We observed that testosterone and its non-aromatizable metabolite dihydrotestosterone (DHT) rapidly and transiently activate MAPK in cultured hippocampal neurons, as evidenced by ..
  69. pmc Effects of dihydrotestosterone on differentiation and proliferation of human mesenchymal stem cells and preadipocytes
    Vandana Gupta
    Department of Medicine, Boston University, School of Medicine, Boston Medical Center, Boston, MA 02118, USA
    Mol Cell Endocrinol 296:32-40. 2008
    ..Here, we investigated whether dihydrotestosterone (DHT) regulates proliferation, differentiation, or functional maturation of hMSCs and human preadipocytes ..
  70. ncbi Inhibition of MCF-7 breast cancer cell proliferation by 5alpha-dihydrotestosterone; a role for p21(Cip1/Waf1)
    M A Greeve
    Department of Anatomical Pathology, Royal Perth Hospital, Wellington Street, Perth, Western Australia 6000, Australia
    J Mol Endocrinol 32:793-810. 2004
    ..In this study, treatment of asynchronously growing MCF-7 breast cancer cells with the androgen, 5alpha-dihydrotestosterone (DHT), was shown to inhibit cell proliferation and induce moderate increases in the proportion of G1 phase ..
  71. doi Dihydrotestosterone sensitises LNCaP cells to death induced by epigallocatechin-3-Gallate (EGCG) or an IGF-I receptor inhibitor
    Francis Thomas
    IGF and Metabolic Endocrinology Group, Department of Clinical Sciences North Bristol, The Medical School Unit, Southmead Hospital, Bristol, UK
    Prostate 69:219-24. 2009
    ..Compelling evidence has accumulated for chemopreventive effects for the active component of green tea Epigallocatechin-3-Gallate (EGCG) particularly for prostate cancer (CaP)...
  72. ncbi Mathematical model for the androgenic regulation of the prostate in intact and castrated adult male rats
    Laura K Potter
    Curriculum in Toxicology, University of North Carolina, Chapel Hill, NC, USA
    Am J Physiol Endocrinol Metab 291:E952-64. 2006
    ..The model describes the systemic and local kinetics of testosterone (T), 5alpha-dihydrotestosterone (DHT), and luteinizing hormone (LH), with metabolism of T to DHT by 5alpha-reductase in liver and prostate...
  73. ncbi Uterine adenocarcinoma in mice following developmental treatment with estrogens: a model for hormonal carcinogenesis
    R R Newbold
    Developmental Endocrinology and Pharmacology Section, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709
    Cancer Res 50:7677-81. 1990
    ..The experimental induction of these tumors will provide the basis for additional studies in mechanisms of hormonal carcinogenesis...
  74. ncbi Insulin-like growth factor binding protein-3 is regulated by dihydrotestosterone and stimulates deoxyribonucleic acid synthesis and cell proliferation in LNCaP prostate carcinoma cells
    J L Martin
    Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St Leonards, New South Wales, Australia
    Endocrinology 141:2401-9. 2000
    ..Confluent monolayers of cells secreted approximately 0.7 ng/ml IGFBP-3 over 24 h. Dihydrotestosterone (DHT, 10 nM) and 1,25-dihydroxyvitamin D3 (vitamin D, 10 nM) increased IGFBP-3 in media to 149 +/- 15% and ..
  75. ncbi Dihydrotestosterone-inducible dickkopf 1 from balding dermal papilla cells causes apoptosis in follicular keratinocytes
    Mi Hee Kwack
    Department of Immunology, School of Medicine, Kyungpook National University, Daegu, Korea
    J Invest Dermatol 128:262-9. 2008
    ..Here, we screened dihydrotestosterone (DHT)-regulated genes in balding DP cells and found that dickkopf 1 (DKK-1) is one of the most upregulated ..
  76. ncbi Testosterone's anti-anxiety and analgesic effects may be due in part to actions of its 5alpha-reduced metabolites in the hippocampus
    Kassandra L Edinger
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Psychoneuroendocrinology 30:418-30. 2005
    ..that if T's anti-anxiety and analgesic effects are due in part to actions of its 5alpha-reduced metabolite (dihydrotestosterone-DHT) and/or its 3alpha-hydroxysteroid dehydrogenase reduced metabolite (3alpha-androstanediol-3alpha-diol), ..
  77. ncbi Differential regulation of rat testicular 5alpha-reductase type 1 and 2 isoforms by testosterone and FSH
    K Pratis
    Prince Henry s Institute of Medical Research, PO Box 5152, Clayton, Victoria 3168, Australia
    J Endocrinol 176:393-403. 2003
    Testosterone is metabolised to the more potent androgen, dihydrotestosterone, by the 5alpha-reductase (5alphaR) enzyme...
  78. pmc Differential effects of testosterone, dihydrotestosterone and estradiol on carotenoid deposition in an avian sexually selected signal
    Stefania Casagrande
    Behavioral Biology, Centre for Behavior and Neuroscience, University of Groningen, Haren, The Netherlands
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 197:1-13. 2011
    ..T can be converted to dihydrotestosterone (DHT) and estradiol (E2), and variation in conversion rate may partly explain some contradictory findings ..
  79. pmc Atmospheric pressure photoionization tandem mass spectrometry of androgens in prostate cancer
    Fred Bjørn Lih
    National Institute of Environmental Health Sciences National Institutes of Health Department of Health and Human Services, Research Triangle Park, North Carolina 27709 2233, USA
    Anal Chem 82:6000-7. 2010
    ..Quantitation of the saturated keto-steroids dihydrotestosterone and 5-alpha-androstanedione required detection of a novel parent ion, [M + 15](+)...
  80. doi 5alpha-dihydrotestosterone (DHT) retards wound closure by inhibiting re-epithelialization
    S C Gilliver
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    J Pathol 217:73-82. 2009
    ..We previously demonstrated that blocking the conversion of testosterone to 5alpha-dihydrotestosterone (DHT) limits its ability to impair healing, suggesting that DHT is a more potent inhibitor of repair than ..
  81. pmc Structural features discriminate androgen receptor N/C terminal and coactivator interactions
    Emily B Askew
    Laboratories for Reproductive Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 7500, USA
    Mol Cell Endocrinol 348:403-10. 2012
    ..We conclude that helix 12 residues outside the AF2 binding cleft modulate AR transcriptional activity by providing flexibility to accommodate FXXLF or LXXLL motif binding...
  82. ncbi Dihydrotestosterone may inhibit hypothalamo-pituitary-adrenal activity by acting through estrogen receptor in the male mouse
    Trent D Lund
    Department of Biomedical Sciences, Colorado State University, Anatomy W103, 1617 Campus Delivery, Fort Collins, CO 80523 1670, USA
    Neurosci Lett 365:43-7. 2004
    ..to environmental perturbation has been shown to be enhanced by estrogen but inhibited by the androgen dihydrotestosterone (DHT). However, the mechanism of androgen's action has not been identified...
  83. ncbi Oxidative 3alpha-hydroxysteroid dehydrogenase activity of human type 10 17beta-hydroxysteroid dehydrogenase
    Xue Ying He
    Department of Pharmacology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    J Steroid Biochem Mol Biol 87:191-8. 2003
    ..catalyzes the oxidation of 5alpha-androstane-3alpha,17beta-diol (adiol), an almost inactive androgen, to dihydrotestosterone (DHT) rather than androsterone or androstanedione...
  84. ncbi Free testosterone and free dihydrotestosterone throughout the life span of men
    Luboslav Starka
    Steroid Hormones Dept, Institute of Endocrinology, Prague, Czech Republic
    J Steroid Biochem Mol Biol 116:118-20. 2009
    The dihydrotestosterone/testosterone ratio seems to be an important factor in the expression of androgenic activity, especially in the prostate and pilosebaceous unit...
  85. pmc Dihydrotestosterone differentially modulates the cortisol response of the hypothalamic-pituitary-adrenal axis in male and female rhesus macaques, and restores circadian secretion of cortisol in females
    Donna J Toufexis
    Division of Developmental and Cognitive Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30322, USA
    Brain Res 1429:43-51. 2012
    ..male rhesus macaques, and replacement with sex-specific low and high physiological doses of dihydrotestosterone (DHT) in the same adult males as well as in adult, gonadally-suppressed, female rhesus macaques...
  86. ncbi Identification of the major oxidative 3alpha-hydroxysteroid dehydrogenase in human prostate that converts 5alpha-androstane-3alpha,17beta-diol to 5alpha-dihydrotestosterone: a potential therapeutic target for androgen-dependent disease
    David R Bauman
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6084, USA
    Mol Endocrinol 20:444-58. 2006
    Androgen-dependent prostate diseases initially require 5alpha-dihydrotestosterone (DHT) for growth...
  87. ncbi The proliferative effects of 5-androstene-3 beta,17 beta-diol and 5 alpha-dihydrotestosterone on cell cycle analysis and cell proliferation in MCF7, T47D and MDAMB231 breast cancer cell lines
    S R Aspinall
    School of Surgery and Reproductive Sciences, The Medical School, University of Newcastle, Newcastle upon Tyne, Benton NE2 4HH, UK
    J Steroid Biochem Mol Biol 88:37-51. 2004
    ..In this study the proliferative affects of 5 alpha-dihydrotestosterone and 5-androstene-3 beta,17 beta-diol, which may be considered true metabolites acting at a tissue level, on ..
  88. ncbi The effect of dutasteride on intraprostatic dihydrotestosterone concentrations in men with benign prostatic hyperplasia
    R Wurzel
    Department of Urology, Grove Hill Medical Center, New Britain, CT 06052, USA
    Prostate Cancer Prostatic Dis 10:149-54. 2007
    The dual 5alpha-reductase inhibitor, dutasteride has been shown to suppress serum dihydrotestosterone (DHT) by >90%. In the present study, the effect of dutasteride 0.5 mg/day on intraprostatic DHT levels was investigated...
  89. pmc Epidermal-growth-factor-dependent phosphorylation and ubiquitinylation of MAGE-11 regulates its interaction with the androgen receptor
    Suxia Bai
    Laboratories for Reproductive Biology, CB 7500, University of North Carolina, Chapel Hill, NC 27599 7500, USA
    Mol Cell Biol 28:1947-63. 2008
    ..EGF in the presence of dihydrotestosterone stabilizes the AR-MAGE complex through the site-specific phosphorylation of MAGE-11 at Thr-360 and ..
  90. pmc Prx1 enhances androgen receptor function in prostate cancer cells by increasing receptor affinity to dihydrotestosterone
    Rishi Raj Chhipa
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Mol Cancer Res 7:1543-52. 2009
    ..In the present study, we evaluated the biological significance of Prx1 in modulating dihydrotestosterone (DHT)-stimulated growth and AR target gene expression of prostate cancer cells...
  91. ncbi Prostatic luminal cell differentiation and prostatic steroid-binding protein (PBP) gene expression are differentially affected by neonatal castration
    L Janulis
    Department of Urology, Northwestern University Medical School, Chicago, IL 60611, USA
    Prostate 43:195-204. 2000
    ..The purpose of this study was to examine the differentiation of prostatic epithelial cells after neonatal castration...
  92. ncbi Gonadal steroid attenuation of developing hamster facial motoneuron loss by axotomy: equal efficacy of testosterone, dihydrotestosterone, and 17-beta estradiol
    Christopher B Huppenbauer
    Department of Cell Biology, Neurobiology, and Anatomy, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois 60153, USA
    J Neurosci 25:4004-13. 2005
    ..The second half examines the neuroprotective effects of testosterone propionate, 17-beta estradiol, and dihydrotestosterone on FMNs of P7 hamsters after facial nerve transection at the SMF...
  93. ncbi Androgen metabolism in the prostate of the finasteride-treated, adult rat: a possible explanation for the differential action of testosterone and 5 alpha-dihydrotestosterone during development of the male urogenital tract
    F W George
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235 8857, USA
    Endocrinology 138:871-7. 1997
    Previous work has clearly demonstrated that inhibition of 5 alpha-dihydrotestosterone (DHT) formation in vivo is not as effective as total androgen ablation (castration) in causing involution of the prostate...
  94. ncbi 5Alpha-dihydrotestosterone up-regulates transthyretin levels in mice and rat choroid plexus via an androgen receptor independent pathway
    T Quintela
    Health Sciences Research Centre CICS, University of Beira Interior, Av Infante D Henrique, 6200 506 Covilha, Portugal
    Brain Res 1229:18-26. 2008
    ..In this study we examined the effects of 5alpha-dihydrotestosterone (DHT) on TTR protein and mRNA levels, in primary cultures of rat CPs epithelial cells (CPEC) by Western ..
  95. pmc Hypothalamic neuroendocrine functions in rats with dihydrotestosterone-induced polycystic ovary syndrome: effects of low-frequency electro-acupuncture
    Yi Feng
    Institute of Neuroscience and Physiology, Department of Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 4:e6638. 2009
    ..Repeated low-frequency EA normalized estrous cyclicity and restored GnRH and AR protein expression. These results may help explain the beneficial neuroendocrine effects of low-frequency EA in women with PCOS...
  96. pmc Testosterone, not 5α-dihydrotestosterone, stimulates LRH-1 leading to FSH-independent expression of Cyp19 and P450scc in granulosa cells
    Yan Guang Wu
    Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Mol Endocrinol 25:656-68. 2011
    ..T can be converted into estradiol, a classical estrogen, by Cyp19 and into 5α-dihydrotestosterone, a pure androgen, by 5α-reductase...
  97. ncbi Impaired dihydrotestosterone catabolism in human prostate cancer: critical role of AKR1C2 as a pre-receptor regulator of androgen receptor signaling
    Qing Ji
    Department of Medicine, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    Cancer Res 67:1361-9. 2007
    ..We now report that dihydrotestosterone (DHT) levels are significantly greater in prostate cancer tumors compared with their paired benign tissues...
  98. ncbi Testosterone decreases reactive astroglia and reactive microglia after brain injury in male rats: role of its metabolites, oestradiol and dihydrotestosterone
    George Barreto
    Instituto Cajal, C S I C, Madrid, Spain
    Eur J Neurosci 25:3039-46. 2007
    ..we have assessed the effect of early and late therapy with testosterone or its metabolites, oestradiol and dihydrotestosterone, on reactive astroglia and reactive microglia after a stab wound brain injury in orchidectomized Wistar ..
  99. ncbi Partitioning of 5alpha-dihydrotestosterone and 5alpha-androstane-3alpha, 17beta-diol activated pathways for stimulating human prostate cancer LNCaP cell proliferation
    Eva H Nunlist
    Department of Urology, University of Oklahoma Health Sciences Center, 920 Stanton L Young Blvd, WP3150, Oklahoma City, OK 73104, USA
    J Steroid Biochem Mol Biol 91:157-70. 2004
    ..Despite our understanding of molecular actions of 5alpha-dihydrotestosterone (5alpha-DHT) in the prostate through the trans-activation of the androgen receptor (AR), comprehensive ..
  100. ncbi Regulation of the initial segment of the murine epididymis by dihydrotestosterone and testicular exocrine secretions studied by expression of specific proteins and gene expression
    C Avram
    Institut für Reproduktionsmedizin, Universitat Munster, Domagkstrasse 11, 48149, Germany
    Cell Tissue Res 317:13-22. 2004
    ..Administration of dihydrotestosterone (DHT) to the castrates maintained the proximal and distal caput epithelia and induced a proximal epithelium,..
  101. ncbi Effects of steroid hormones on spermatogenesis and GnRH release in male Leopard frogs, Rana pipiens
    Pei San Tsai
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309 0354, USA
    Gen Comp Endocrinol 134:330-8. 2003
    ..suggest reproduction in the ranid frogs is potently regulated by the gonadal steroids, in particular 5alpha-dihydrotestosterone (DHT) and 17beta-estradiol (E(2)), and a non-gonadal steroid, the stress hormone corticosterone (Cort)...

Research Grants78

  1. Role of 5-alpha Reductase in Testosterone Actions
    Shalendar Bhasin; Fiscal Year: 2007
    ..as a prohormone that is converted in the body to two active metabolites, estradiol 17beta and 5-alpha dihydrotestosterone (DHT)...
  2. ALTERED METABOLISM AND CARCINOGENESIS BY DES
    CORAL LAMARTINIERE; Fiscal Year: 1990
    ..which (designated P-450a) catalyzes the 7 alpha-hydroxylation of testosterone, androstenedione and 5 alpha-dihydrotestosterone. Antibodies against cytochrome P-450a recognize two other forms of rat liver microsomal cytochrome P-450, ..
  3. Androgen Modulation of Neurodegeneration in Dopamine Neurons
    Rebecca L Cunningham; Fiscal Year: 2009
    ..gonadally intact aged males, and gonadectomized aged males plus replacement androgen (testosterone or dihydrotestosterone) for either a chronic (3 months) or acute (1 week) treatment time length prior to 6-OHDA lesion...
  4. Androgen Modulation of Neurodegeneration in Dopamine Neurons
    Rebecca L Cunningham; Fiscal Year: 2010
    ..gonadally intact aged males, and gonadectomized aged males plus replacement androgen (testosterone or dihydrotestosterone) for either a chronic (3 months) or acute (1 week) treatment time length prior to 6-OHDA lesion...
  5. PROGESTERONE RECEPTOR AND ACTION IN THE PRIMATE OVARY
    Richard Stouffer; Fiscal Year: 2007
    ..a 3p-hydroxysteroid dehydrogenase inhibitor) and P (R5020) or other steroid (estrogen, R2858 or androgen, dihydrotestosterone) replacements...
  6. PROGESTERONE RECEPTOR AND ACTION IN THE PRIMATE OVARY
    Richard Stouffer; Fiscal Year: 2009
    ..a 3p-hydroxysteroid dehydrogenase inhibitor) and P (R5020) or other steroid (estrogen, R2858 or androgen, dihydrotestosterone) replacements...
  7. PROGESTERONE RECEPTOR AND ACTION IN THE PRIMATE OVARY
    Richard L Stouffer; Fiscal Year: 2010
    ..a 3p-hydroxysteroid dehydrogenase inhibitor) and P (R5020) or other steroid (estrogen, R2858 or androgen, dihydrotestosterone) replacements...
  8. PROGESTERONE RECEPTOR AND ACTION IN THE PRIMATE OVARY
    Richard Stouffer; Fiscal Year: 2006
    ..a 3p-hydroxysteroid dehydrogenase inhibitor) and P (R5020) or other steroid (estrogen, R2858 or androgen, dihydrotestosterone) replacements...
  9. Role of 5-alpha Reductase in Testosterone Actions
    Shalender Bhasin; Fiscal Year: 2004
    ..as a prohormone that is converted in the body to two active metabolites, estradiol 17beta and 5-alpha dihydrotestosterone (DHT)...
  10. Role of 5-alpha Reductase in Testosterone Actions
    Shalender Bhasin; Fiscal Year: 2006
    ..as a prohormone that is converted in the body to two active metabolites, estradiol 17beta and 5-alpha dihydrotestosterone (DHT)...
  11. Role of 5-alpha Reductase in Testosterone Actions
    Shalender Bhasin; Fiscal Year: 2004
    ..as a prohormone that is converted in the body to two active metabolites, estradiol 17beta and 5-alpha dihydrotestosterone (DHT)...
  12. Role of 5-alpha Reductase in Testosterone Actions
    Shalender Bhasin; Fiscal Year: 2005
    ..as a prohormone that is converted in the body to two active metabolites, estradiol 17beta and 5-alpha dihydrotestosterone (DHT)...
  13. Role of 5-alpha Reductase in Testosterone Actions
    Shalender Bhasin; Fiscal Year: 2003
    ..as a prohormone that is converted in the body to two active metabolites, estradiol 17beta and 5-alpha dihydrotestosterone (DHT)...
  14. Hormonal Regulation of Sex Differences in Stress Effects in Prefrontal Cortex
    Cara L Wellman; Fiscal Year: 2010
    ..and unstressed rats that have undergone castration and implantation of either no hormone, testosterone, dihydrotestosterone, or estradiol...
  15. Maintainance of Organ Function Following Injury
    Irshad Chaudry; Fiscal Year: 2006
    Our recent studies indicate that depletion of androgens (testosterone and dihydrotestosterone) two weeks prior to onset of hemorrhage prevents the depression of cardiac function following trauma-hemorrhage and resuscitation...
  16. FREE PLASMA SEX HORMONE AND ANDROGEN ACTION
    Robert Rosenfield; Fiscal Year: 1980
    ..be developed for the measurement of the major plasma androgens--the 17 beta-hydroxysteroids (testosterone, dihydrotestosterone, delta 5-androstenediol, and 3 alpha/3 beta-androstanediols) and 17-ketosteroids (androstenedione and ..
  17. MOLECULAR EPIDEMIOLOGY OF BIRTH DEFECTS
    Jeanne Manson; Fiscal Year: 2000
    ..studies indicate at SRD5A2 enzyme activity is critical in formation of the external male genital tract, and dihydrotestosterone produced by this enzyme is essential for normal development of the penis, scrotum and prostate...
  18. MOLECULAR EPIDEMIOLOGY OF BIRTH DEFECTS
    Jeanne Manson; Fiscal Year: 2000
    ..studies indicate at SRD5A2 enzyme activity is critical in formation of the external male genital tract, and dihydrotestosterone produced by this enzyme is essential for normal development of the penis, scrotum and prostate...
  19. MAINTENANCE OF ORGAN FUNCTION FOLLOWING INJURY
    Irshad Chaudry; Fiscal Year: 2003
    Our recent studies indicate that depletion of androgens (testosterone and dihydrotestosterone) two weeks prior to onset of hemorrhage prevents the depression of cardiac function following trauma-hemorrhage and resuscitation...
  20. MAINTENANCE OF ORGAN FUNCTION FOLLOWING INJURY
    Irshad Chaudry; Fiscal Year: 2002
    Our recent studies indicate that depletion of androgens (testosterone and dihydrotestosterone) two weeks prior to onset of hemorrhage prevents the depression of cardiac function following trauma-hemorrhage and resuscitation...
  21. MAINTENANCE OF ORGAN FUNCTION FOLLOWING INJURY
    Irshad Chaudry; Fiscal Year: 2001
    Our recent studies indicate that depletion of androgens (testosterone and dihydrotestosterone) two weeks prior to onset of hemorrhage prevents the depression of cardiac function following trauma-hemorrhage and resuscitation...
  22. MAINTENANCE OF ORGAN FUNCTION FOLLOWING INJURY
    Irshad Chaudry; Fiscal Year: 2000
    Our recent studies indicate that depletion of androgens (testosterone and dihydrotestosterone) two weeks prior to onset of hemorrhage prevents the depression of cardiac function following trauma-hemorrhage and resuscitation...
  23. MAINTENANCE OF ORGAN FUNCTION FOLLOWING INJURY
    Irshad Chaudry; Fiscal Year: 2000
    Our recent studies indicate that depletion of androgens (testosterone and dihydrotestosterone) two weeks prior to onset of hemorrhage prevents the depression of cardiac function following trauma-hemorrhage and resuscitation...
  24. MAINTENANCE OF ORGAN FUNCTION FOLLOWING INJURY
    Irshad Chaudry; Fiscal Year: 1999
    Our recent studies indicate that depletion of androgens (testosterone and dihydrotestosterone) two weeks prior to onset of hemorrhage prevents the depression of cardiac function following trauma-hemorrhage and resuscitation...
  25. Maintainance of Organ Function Following Injury
    Irshad Chaudry; Fiscal Year: 2007
    Our recent studies indicate that depletion of androgens (testosterone and dihydrotestosterone) two weeks prior to onset of hemorrhage prevents the depression of cardiac function following trauma-hemorrhage and resuscitation...
  26. BIOCHEMICAL TOXICOLOGY OF CYTOCHROME P-450
    Andrew Parkinson; Fiscal Year: 1991
    ..which (designated P-450a) catalyzes the 7 alpha-hydroxylation of testosterone, androstenedione and 5 alpha-dihydrotestosterone. Antibodies against cytochrome P-450a recognize two other forms of rat liver microsomal cytochrome P-450, ..
  27. BIOCHEMICAL TOXICOLOGY OF CYTOCHROME P-450
    Andrew Parkinson; Fiscal Year: 1993
    ..which (designated P-450a) catalyzes the 7 alpha-hydroxylation of testosterone, androstenedione and 5 alpha-dihydrotestosterone. Antibodies against cytochrome P-450a recognize two other forms of rat liver microsomal cytochrome P-450, ..
  28. HORMONAL REGULATION OF ETHANOL METABOLISM
    Esteban Mezey; Fiscal Year: 1999
    ..Alcohol dehydrogenase is increased by growth hormone and suppressed by dihydrotestosterone. Glucagon and epinephrine enhance alcohol dehydrogenase and this effect is most likely mediated by cAMP...
  29. HORMONAL REGULATION OF ETHANOL METABOLISM
    Esteban Mezey; Fiscal Year: 2000
    ..Alcohol dehydrogenase is increased by growth hormone and suppressed by dihydrotestosterone. Glucagon and epinephrine enhance alcohol dehydrogenase and this effect is most likely mediated by cAMP...
  30. Impact of Puberty on the Kidney in Diabetes
    PASCALE LANE; Fiscal Year: 2003
    ..the role of the androgen receptor in the renal response to DM; and 5)Determine whether conversion to dihydrotestosterone is necessary for the post-pubertal renal response to STZ DM...
  31. Impact of Puberty on the Kidney in Diabetes
    PASCALE LANE; Fiscal Year: 2004
    ..the role of the androgen receptor in the renal response to DM; and 5)Determine whether conversion to dihydrotestosterone is necessary for the post-pubertal renal response to STZ DM...
  32. Impact of Puberty on the Kidney in Diabetes
    PASCALE LANE; Fiscal Year: 2005
    ..the role of the androgen receptor in the renal response to DM; and 5)Determine whether conversion to dihydrotestosterone is necessary for the post-pubertal renal response to STZ DM...
  33. PROSTATIC DIFFERENTIATION AND SEX HORMONE METABOLISM
    Shuk Mei Ho; Fiscal Year: 2004
    ..T, 5alpha-dihydrotestosterone (DHT), PRL and E2 were shown to exert different proliferation- and dysplasia-promoting actions on explants ..
  34. PROSTATIC DIFFERENTIATION AND SEX HORMONE METABOLISM
    Shuk Mei Ho; Fiscal Year: 2006
    ..T, 5alpha-dihydrotestosterone (DHT), PRL and E2 were shown to exert different proliferation- and dysplasia-promoting actions on explants ..
  35. Impact of Puberty on the Kidney in Diabetes
    PASCALE LANE; Fiscal Year: 2004
    ..the role of the androgen receptor in the renal response to DM; and 5)Determine whether conversion to dihydrotestosterone is necessary for the post-pubertal renal response to STZ DM...
  36. PROSTATIC DIFFERENTIATION AND SEX HORMONE METABOLISM
    Shuk Mei Ho; Fiscal Year: 2005
    ..T, 5alpha-dihydrotestosterone (DHT), PRL and E2 were shown to exert different proliferation- and dysplasia-promoting actions on explants ..
  37. Impact of Puberty on the Kidney in Diabetes
    PASCALE LANE; Fiscal Year: 2001
    ..the role of the androgen receptor in the renal response to DM; and 5)Determine whether conversion to dihydrotestosterone is necessary for the post-pubertal renal response to STZ DM...
  38. Impact of Puberty on the Kidney in Diabetes
    PASCALE LANE; Fiscal Year: 2002
    ..the role of the androgen receptor in the renal response to DM; and 5)Determine whether conversion to dihydrotestosterone is necessary for the post-pubertal renal response to STZ DM...
  39. PROSTATIC DIFFERENTIATION AND SEX HORMONE METABOLISM
    Shuk Mei Ho; Fiscal Year: 2007
    ..T, 5alpha-dihydrotestosterone (DHT), PRL and E2 were shown to exert different proliferation- and dysplasia-promoting actions on explants ..
  40. PROSTATIC DIFFERENTIATION AND SEX HORMONE METABOLISM
    Shuk Mei Ho; Fiscal Year: 2005
    ..T, 5alpha-dihydrotestosterone (DHT), PRL and E2 were shown to exert different proliferation- and dysplasia-promoting actions on explants ..
  41. Androgen Receptor Function in Prostate Cancer
    Richard G Pestell; Fiscal Year: 2012
    ..AR acetylation and phosphorylation are linked, 2. SirT1 expression and function are regulated by dihydrotestosterone (DHT) and metabolism 3. AR is repressed by the NAD-dependent histone deacetylases (SirT1), and 4...
  42. Association between the Y chromosome and androgens
    Kathryn Sandberg; Fiscal Year: 2007
    ..Serum concentrations of free testosterone, dehydroepiandrosterone, dehydroepiandrosterone sulfate and dihydrotestosterone will be assessed by radioimmunoassay...
  43. Androgen Receptor Function in Prostate Cancer
    Richard Pestell; Fiscal Year: 2009
    ..AR acetylation and phosphorylation are linked, 2. SirT1 expression and function are regulated by dihydrotestosterone (DHT) and metabolism 3. AR is repressed by the NAD-dependent histone deacetylases (SirT1), and 4...
  44. Equol and Regulation of Prostate Growth
    Robert Handa; Fiscal Year: 2009
    ..circulating testosterone;inhibition of 5-alpha reductase, an enzyme that synthesizes the potent androgen, dihydrotestosterone;or blocking the actions of the androgen receptor...
  45. Association between the Y chromosome and androgens
    Kathryn Sandberg; Fiscal Year: 2006
    ..Serum concentrations of free testosterone, dehydroepiandrosterone, dehydroepiandrosterone sulfate and dihydrotestosterone will be assessed by radioimmunoassay...
  46. Androgen Receptor Function in Prostate Cancer
    Richard G Pestell; Fiscal Year: 2010
    ..AR acetylation and phosphorylation are linked, 2. SirT1 expression and function are regulated by dihydrotestosterone (DHT) and metabolism 3. AR is repressed by the NAD-dependent histone deacetylases (SirT1), and 4...
  47. ANDROGENIC STEROIDS/PROTEIN METABOLISM/MUSCLE STRENGTH
    Shalender Bhasin; Fiscal Year: 1992
    ..In addition total and free testosterone (T), dihydrotestosterone, LH, FSH and SHBG levels will be monitored before, during and after treatment as markers of androgen ..
  48. Equol and Regulation of Prostate Growth
    Robert J Handa; Fiscal Year: 2010
    ..circulating testosterone;inhibition of 5-alpha reductase, an enzyme that synthesizes the potent androgen, dihydrotestosterone;or blocking the actions of the androgen receptor...
  49. Association between the Y chromosome and androgens
    Kathryn Sandberg; Fiscal Year: 2005
    ..Serum concentrations of free testosterone, dehydroepiandrosterone, dehydroepiandrosterone sulfate and dihydrotestosterone will be assessed by radioimmunoassay...
  50. BPH AND PROSTATE CA IN 5A-REDUCTASE-2 DEFICIENT CARRIERS
    Julianne Imperato McGinley; Fiscal Year: 1999
    The major phase of this study if designed to test the hypothesis that a mild decrease in dihydrotestosterone (DHT) throughout life will prevent the development of benign prostatic hyperplasia and prostate cancer...
  51. BPH AND PROSTATE CA IN 5A-REDUCTASE-2 DEFICIENT CARRIERS
    Julianne Imperato McGinley; Fiscal Year: 2000
    The major phase of this study if designed to test the hypothesis that a mild decrease in dihydrotestosterone (DHT) throughout life will prevent the development of benign prostatic hyperplasia and prostate cancer...
  52. A Novel Synthetic Androgen Receptor Antagonist
    Zhongyun Dong; Fiscal Year: 2009
    ..DL3 inhibits dihydrotestosterone (DHT)-stimulated cell growth and gene expression in all prostate cancer cell lines tested, including ..
  53. A Novel Synthetic Androgen Receptor Antagonist
    Zhongyun Dong; Fiscal Year: 2010
    ..DL3 inhibits dihydrotestosterone (DHT)-stimulated cell growth and gene expression in all prostate cancer cell lines tested, including ..
  54. Estrogen Metabolism and Action in Prostate Cancer Etiology in the PCPT
    Ashraful Hoque; Fiscal Year: 2006
    ..inhibitor finasteride (versus placebo) found that inhibiting SRD5A2 from converting testosterone into dihydrotestosterone reduced total prostate cancer risk by 25%, but also increased the risk of high-grade cancer...
  55. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad Chaudry; Fiscal Year: 2006
    ..Studies also show that increased 5alpha-dihydrotestosterone synthesis in T cells is the likely cause for immune depression in males, while continued E2 synthesis ..
  56. Estrogen Metabolism and Action in Prostate Cancer Etiology in PCPT
    Ashraful Hoque; Fiscal Year: 2007
    ..inhibitor finasteride (versus placebo) found that inhibiting SRD5A2 from converting testosterone into dihydrotestosterone reduced total prostate cancer risk by 25%, but also increased the risk of high-grade cancer...
  57. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad Chaudry; Fiscal Year: 2004
    ..Studies also show that increased 5alpha-dihydrotestosterone synthesis in T cells is the likely cause for immune depression in males, while continued E2 synthesis ..
  58. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad Chaudry; Fiscal Year: 2005
    ..Studies also show that increased 5alpha-dihydrotestosterone synthesis in T cells is the likely cause for immune depression in males, while continued E2 synthesis ..
  59. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad Chaudry; Fiscal Year: 2003
    ..Studies also show that increased 5alpha-dihydrotestosterone synthesis in T cells is the likely cause for immune depression in males, while continued E2 synthesis ..
  60. STEROID 5 ALPHA REDUCTASE--STRUCTURE/FUNCTION
    Shutsung Liao; Fiscal Year: 2000
    ..5a-Reductase converts testosterone, the major circulating androgen in men, to dihydrotestosterone, a process believed to amplify the androgenic signal...
  61. STEROID 5 ALPHA REDUCTASE--STRUCTURE/FUNCTION
    Shutsung Liao; Fiscal Year: 1999
    ..5a-Reductase converts testosterone, the major circulating androgen in men, to dihydrotestosterone, a process believed to amplify the androgenic signal...
  62. MECHANISMS OF CYCLIC LH AND FSH RELEASE
    CHARLES BLAKE; Fiscal Year: 1991
    ..Some hosts will receive sc implants of Silastic elastomer capsules containing testosterone (T), 5alpha- dihydrotestosterone (DHT), or contain immunoreactive LH, FSH, or both hormones using immunocytochemistry (ICC); size of LH and ..
  63. Mechanisms of Testosterone Effects on Body Composition
    Shalendar Bhasin; Fiscal Year: 2007
    ..We hypothesize that testosterone and dihydrotestosterone (DHT), two prototypical androgens, promote the differentiation of adult, pluripotent mesenchymal stem cells ..
  64. Mechanisms of Testosterone Effects on Body Composition
    Shalender Bhasin; Fiscal Year: 2006
    ..We hypothesize that testosterone and dihydrotestosterone (DHT), two prototypical androgens, promote the differentiation of adult, pluripotent mesenchymal stem cells ..
  65. Mechanisms of Testosterone Effects on Body Composition
    Shalender Bhasin; Fiscal Year: 2005
    ..We hypothesize that testosterone and dihydrotestosterone (DHT), two prototypical androgens, promote the differentiation of adult, pluripotent mesenchymal stem cells ..
  66. Mechanisms of Testosterone Effects on Body Composition
    Shalender Bhasin; Fiscal Year: 2004
    ..We hypothesize that testosterone and dihydrotestosterone (DHT), two prototypical androgens, promote the differentiation of adult, pluripotent mesenchymal stem cells ..
  67. Testosterone:Physical Function in Men on Hemodialysis
    Shalender Bhasin; Fiscal Year: 2003
    ..Total and free testosterone and dihydrotestosterone levels will be measured as markers of androgen bioavailability, and LH, FSH, and SHBG as markers of ..
  68. Testosterone:Physical Function in Men on Hemodialysis
    Shalender Bhasin; Fiscal Year: 2003
    ..Total and free testosterone and dihydrotestosterone levels will be measured as markers of androgen bioavailability, and LH, FSH, and SHBG as markers of ..
  69. Testosterone:Physical Function in Men on Hemodialysis
    Shalender Bhasin; Fiscal Year: 2004
    ..Total and free testosterone and dihydrotestosterone levels will be measured as markers of androgen bioavailability, and LH, FSH, and SHBG as markers of ..
  70. Testosterone:Physical Function in Men on Hemodialysis
    Shalender Bhasin; Fiscal Year: 2004
    ..Total and free testosterone and dihydrotestosterone levels will be measured as markers of androgen bioavailability, and LH, FSH, and SHBG as markers of ..
  71. Testosterone:Physical Function in Men on Hemodialysis
    Shalender Bhasin; Fiscal Year: 2001
    ..Total and free testosterone and dihydrotestosterone levels will be measured as markers of androgen bioavailability, and LH, FSH, and SHBG as markers of ..
  72. Testosterone:Physical Function in Men on Hemodialysis
    Shalender Bhasin; Fiscal Year: 2002
    ..Total and free testosterone and dihydrotestosterone levels will be measured as markers of androgen bioavailability, and LH, FSH, and SHBG as markers of ..
  73. In vivo effects of sulforaphane supplementation on normal human prostate
    DANIEL W contact LIN; Fiscal Year: 2010
    ..and reduces oxidative damage in human prostate and (2) increases DHT catabolism and reduces intra-prostatic dihydrotestosterone (DHT) concentration...