dihydrotestosterone

Summary

Summary: A potent androgenic metabolite of TESTOSTERONE. Dihydrotestosterone (DHT) is generated by a 5-alpha reduction of testosterone. Unlike testosterone, DHT cannot be aromatized to ESTRADIOL therefore DHT is considered a pure androgenic steroid.

Top Publications

  1. ncbi Developmental time course of estradiol, testosterone, and dihydrotestosterone levels in discrete regions of male and female rat brain
    Anne T M Konkle
    Faculty of Health Sciences, Interdisciplinary School of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
    Endocrinology 152:223-35. 2011
  2. ncbi The androgen axis in recurrent prostate cancer
    James L Mohler
    Department of Surgery, Division of Urology, Pathology and Laboratory Medicine, University of North Carolina Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
    Clin Cancer Res 10:440-8. 2004
  3. ncbi Testosterone and dihydrotestosterone tissue levels in recurrent prostate cancer
    Mark A Titus
    Department of Pathology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, 27599 7295, USA
    Clin Cancer Res 11:4653-7. 2005
  4. ncbi A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome
    Louise Mannerås
    Institute of Neuroscience and Physiology, Department of Physiology, Sahlgrenska Academy, Goteborg University, Box 434, SE 405 30 Goteborg, Sweden
    Endocrinology 148:3781-91. 2007
  5. ncbi Endothelial regulation of eNOS, PAI-1 and t-PA by testosterone and dihydrotestosterone in vitro and in vivo
    L Goglia
    Department of Reproductive Medicine and Child Development, Molecular and Cellular Gynecological Endocrinology Laboratory MCGEL, University of Pisa, Pisa, Italy
    Mol Hum Reprod 16:761-9. 2010
  6. ncbi The androgen 5alpha-dihydrotestosterone and its metabolite 5alpha-androstan-3beta, 17beta-diol inhibit the hypothalamo-pituitary-adrenal response to stress by acting through estrogen receptor beta-expressing neurons in the hypothalamus
    Trent D Lund
    Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    J Neurosci 26:1448-56. 2006
  7. ncbi Tissue culture media supplemented with 10% fetal calf serum contains a castrate level of testosterone
    J P Michiel Sedelaar
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, School of Medicine, Baltimore, MD 21231, USA
    Prostate 69:1724-9. 2009
  8. ncbi Activated androgen receptor downregulates E-cadherin gene expression and promotes tumor metastasis
    Yan Nian Liu
    Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan
    Mol Cell Biol 28:7096-108. 2008
  9. ncbi Modulation of androgen receptor activation function 2 by testosterone and dihydrotestosterone
    Emily B Askew
    Curriculum in Toxicology, Laboratories for Reproductive Biology, Lineberger Comprehensive Cancer Center, Department of Pediatrics, University of North Carolina, Chapel Hill 27599, USA
    J Biol Chem 282:25801-16. 2007
  10. ncbi Upregulation of prostate specific membrane antigen/folate hydrolase transcription by an enhancer
    Kenneth R Noss
    Research Service (151, Overton Brooks Veterans Administration Medical Center, Shreveport, LA 71101-4295, USA
    Gene 285:247-56. 2002

Research Grants

  1. Role of 5-alpha Reductase in Testosterone Actions
    Shalendar Bhasin; Fiscal Year: 2007
  2. PROGESTERONE RECEPTOR AND ACTION IN THE PRIMATE OVARY
    Richard Stouffer; Fiscal Year: 2007
  3. PROGESTERONE RECEPTOR AND ACTION IN THE PRIMATE OVARY
    Richard Stouffer; Fiscal Year: 2009
  4. PROGESTERONE RECEPTOR AND ACTION IN THE PRIMATE OVARY
    Richard L Stouffer; Fiscal Year: 2010
  5. FREE PLASMA SEX HORMONE AND ANDROGEN ACTION
    Robert Rosenfield; Fiscal Year: 1980
  6. Impact of Puberty on the Kidney in Diabetes
    PASCALE LANE; Fiscal Year: 2005
  7. Maintainance of Organ Function Following Injury
    Irshad Chaudry; Fiscal Year: 2007
  8. HORMONAL REGULATION OF ETHANOL METABOLISM
    Esteban Mezey; Fiscal Year: 2000
  9. PROSTATIC DIFFERENTIATION AND SEX HORMONE METABOLISM
    Shuk Mei Ho; Fiscal Year: 2007
  10. Equol and Regulation of Prostate Growth
    Robert J Handa; Fiscal Year: 2010

Detail Information

Publications221 found, 100 shown here

  1. ncbi Developmental time course of estradiol, testosterone, and dihydrotestosterone levels in discrete regions of male and female rat brain
    Anne T M Konkle
    Faculty of Health Sciences, Interdisciplinary School of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
    Endocrinology 152:223-35. 2011
    ..profile of steroids in the rat brain using RIA to quantify the level of estradiol, testosterone, and dihydrotestosterone in discrete subregions of the brain from embryonic d 19 to adulthood...
  2. ncbi The androgen axis in recurrent prostate cancer
    James L Mohler
    Department of Surgery, Division of Urology, Pathology and Laboratory Medicine, University of North Carolina Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
    Clin Cancer Res 10:440-8. 2004
    ..High levels of expression of androgen receptor and androgen receptor-regulated genes in recurrent prostate cancer suggest a role for androgen receptor and its ligands in prostate cancer recurrence...
  3. ncbi Testosterone and dihydrotestosterone tissue levels in recurrent prostate cancer
    Mark A Titus
    Department of Pathology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, 27599 7295, USA
    Clin Cancer Res 11:4653-7. 2005
    ..Many groups have pursued mechanisms of ligand-independent androgen receptor activation but we found high levels of testicular androgens in recurrent prostate cancer tissue using RIA...
  4. ncbi A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome
    Louise Mannerås
    Institute of Neuroscience and Physiology, Department of Physiology, Sahlgrenska Academy, Goteborg University, Box 434, SE 405 30 Goteborg, Sweden
    Endocrinology 148:3781-91. 2007
    ..Female rats received the nonaromatizable androgen dihydrotestosterone (DHT) or the aromatase inhibitor letrozole by continuous administration, beginning before puberty, to ..
  5. ncbi Endothelial regulation of eNOS, PAI-1 and t-PA by testosterone and dihydrotestosterone in vitro and in vivo
    L Goglia
    Department of Reproductive Medicine and Child Development, Molecular and Cellular Gynecological Endocrinology Laboratory MCGEL, University of Pisa, Pisa, Italy
    Mol Hum Reprod 16:761-9. 2010
    ..of this study is the identification of direct endothelial regulation by the androgens testosterone (T) and dihydrotestosterone (DHT)...
  6. ncbi The androgen 5alpha-dihydrotestosterone and its metabolite 5alpha-androstan-3beta, 17beta-diol inhibit the hypothalamo-pituitary-adrenal response to stress by acting through estrogen receptor beta-expressing neurons in the hypothalamus
    Trent D Lund
    Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    J Neurosci 26:1448-56. 2006
    ..action on these neurons, we examined the effects of central implants of 17beta-estradiol (E2), 5alpha-dihydrotestosterone (DHT), the DHT metabolite 5alpha-androstan-3beta, 17beta-diol (3beta-diol), and several ER subtype-..
  7. ncbi Tissue culture media supplemented with 10% fetal calf serum contains a castrate level of testosterone
    J P Michiel Sedelaar
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, School of Medicine, Baltimore, MD 21231, USA
    Prostate 69:1724-9. 2009
    ..e., DC-FCS) is often used instead of FCS to minimize the level of androgen provided in 10% serum supplemented media. Therefore, total and free testosterone levels in 10%DC-FCS containing media were likewise determined...
  8. ncbi Activated androgen receptor downregulates E-cadherin gene expression and promotes tumor metastasis
    Yan Nian Liu
    Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan
    Mol Cell Biol 28:7096-108. 2008
    ..Treating cells with the AR ligand, dihydrotestosterone (DHT), triggered the reduction of E-cadherin expression and induced changes in cell morphology from an ..
  9. ncbi Modulation of androgen receptor activation function 2 by testosterone and dihydrotestosterone
    Emily B Askew
    Curriculum in Toxicology, Laboratories for Reproductive Biology, Lineberger Comprehensive Cancer Center, Department of Pediatrics, University of North Carolina, Chapel Hill 27599, USA
    J Biol Chem 282:25801-16. 2007
    ..transcriptionally activated by high affinity binding of testosterone (T) or its 5alpha-reduced metabolite, dihydrotestosterone (DHT), a more potent androgen required for male reproductive tract development...
  10. ncbi Upregulation of prostate specific membrane antigen/folate hydrolase transcription by an enhancer
    Kenneth R Noss
    Research Service (151, Overton Brooks Veterans Administration Medical Center, Shreveport, LA 71101-4295, USA
    Gene 285:247-56. 2002
    ..These results demonstrate significant upregulation of transcription by the PSMA promoter/enhancer, with specificity for the LNCaP prostate cell line, and downregulation of transcription in response to physiological levels of androgen...
  11. ncbi Stereo-selective inhibition of transient receptor potential TRPC5 cation channels by neuroactive steroids
    Y Majeed
    Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, UK
    Br J Pharmacol 162:1509-20. 2011
    ..Steroids are known to modulate fear and anxiety states, and we therefore investigated whether TRPC5 exhibited sensitivity to steroids...
  12. ncbi Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer
    Kai Hsiung Chang
    Division of Hematology and Oncology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8852, USA
    Proc Natl Acad Sci U S A 108:13728-33. 2011
    ..The development of CRPC is dependent upon the intratumoral generation of the potent androgen, dihydrotestosterone (DHT), from adrenal precursor steroids...
  13. ncbi Lack of effect of testosterone and dihydrotestosterone compared to 17beta-oestradiol in 1-methyl-4-phenyl-1,2,3,6, tetrahydropyridine-mice
    A Ekue
    Molecular Endocrinology and Oncology Research Center, Laval University Medical Center, CHUL and Faculty of Pharmacy, Laval University, Quebec, Canada
    J Neuroendocrinol 14:731-6. 2002
    ..The effects of 17beta-oestradiol (2 microg/day), testosterone (100 microg/day) and dihydrotestosterone (DHT) (2 microg/day or 100 microg/day) were studied during 5 days before and after an acute treatment of ..
  14. ncbi Dihydrotestosterone sensitises LNCaP cells to death induced by epigallocatechin-3-Gallate (EGCG) or an IGF-I receptor inhibitor
    Francis Thomas
    IGF and Metabolic Endocrinology Group, Department of Clinical Sciences North Bristol, The Medical School Unit, Southmead Hospital, Bristol, UK
    Prostate 69:219-24. 2009
    ..Compelling evidence has accumulated for chemopreventive effects for the active component of green tea Epigallocatechin-3-Gallate (EGCG) particularly for prostate cancer (CaP)...
  15. ncbi The role of 5alpha-reduction in steroid hormone physiology
    J D Wilson
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75390 8857, USA
    Reprod Fertil Dev 13:673-8. 2001
    A role for 5alpha-reduction in androgen physiology was first established with the recognition that dihydrotestosterone, the 5alpha-reduced metabolite of testosterone, is formed in many androgen target tissues, binds to the androgen ..
  16. ncbi Pharmacologic basis for the enhanced efficacy of dutasteride against prostatic cancers
    Yi Xu
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Clin Cancer Res 12:4072-9. 2006
    Prostatic dihydrotestosterone (DHT) concentration is regulated by precursors from systemic circulation and prostatic enzymes of androgen metabolism, particularly 5alpha-reductases (i.e., SRD5A1 and SRD5A2)...
  17. ncbi Role of androgens on MCF-7 breast cancer cell growth and on the inhibitory effect of letrozole
    Luciana F Macedo
    Department of Pharmacology and Experimental Therapeutics, University of Maryland, 685 West Baltimore Street, Baltimore, MD 21201, USA
    Cancer Res 66:7775-82. 2006
    ..Here, we report that androgens, such as the aromatizable androstenedione and the non-aromatizable 5alpha-dihydrotestosterone, inhibit MCF-7 cell proliferation...
  18. ncbi Estrogen receptor-beta mediates dihydrotestosterone-induced stimulation of the arginine vasopressin promoter in neuronal cells
    Toni R Pak
    Department of Biomedical Science, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523, USA
    Endocrinology 148:3371-82. 2007
    ..However, 5alpha-dihydrotestosterone (DHT) has also been shown to play a role in the regulation of AVP expression, thus implicating the ..
  19. ncbi Potential prostate cancer drug target: bioactivation of androstanediol by conversion to dihydrotestosterone
    James L Mohler
    Department of Urology, Roswell Park Cancer Institute, Department of Urology, University at Buffalo, State University of New York, Buffalo, New York, USA
    Clin Cancer Res 17:5844-9. 2011
    High-affinity binding of dihydrotestosterone (DHT) to the androgen receptor (AR) initiates androgen-dependent gene activation, required for normal male sex development in utero, and contributes to prostate cancer development and ..
  20. ncbi A novel spreadsheet method for calculating the free serum concentrations of testosterone, dihydrotestosterone, estradiol, estrone and cortisol: with illustrative examples from male and female populations
    Norman A Mazer
    Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston, MA, United States
    Steroids 74:512-9. 2009
    In humans, testosterone (T), dihydrotestosterone (DHT), estradiol (E2), estrone (E1) and cortisol (C) bind to the serum proteins sex hormone-binding globulin (SHBG), albumin (Alb) and corticosteroid-binding globulin (CBG)...
  21. ncbi Activation of the androgen receptor by intratumoral bioconversion of androstanediol to dihydrotestosterone in prostate cancer
    James L Mohler
    Department of Urology, Roswell Park Cancer Institute, Buffalo, New York, USA
    Cancer Res 71:1486-96. 2011
    The androgen receptor (AR) mediates the growth of benign and malignant prostate in response to dihydrotestosterone (DHT)...
  22. ncbi A novel ultrapressure liquid chromatography tandem mass spectrometry method for the simultaneous determination of androstenedione, testosterone, and dihydrotestosterone in pediatric blood samples: age- and sex-specific reference data
    A E Kulle
    Department of Pediatrics, Christian Albrechts University of Kiel, 24105 Kiel, Germany
    J Clin Endocrinol Metab 95:2399-409. 2010
    ..Mass spectrometry-based methods are available for individual steroids but need complex sample preparation and report only fragmentary reference data for the pediatric population...
  23. ncbi Marked suppression of dihydrotestosterone in men with benign prostatic hyperplasia by dutasteride, a dual 5alpha-reductase inhibitor
    Richard V Clark
    Clinical Pharmacology, GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina 27709, USA
    J Clin Endocrinol Metab 89:2179-84. 2004
    b>Dihydrotestosterone (DHT) is the primary metabolite of testosterone in the prostate and skin. Testosterone is converted to DHT by 5alpha-reductase, which exists in two isoenzyme forms (types 1 and 2)...
  24. ncbi Differential regulation of steroid 5alpha-reductase isozymes expression by androgens in the adult rat brain
    J M Torres
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Granada, Avda. de Madrid s/n, 18012 Granada, Spain
    FASEB J 17:1428-33. 2003
    ..of 5alpha-R in the brain derives from its capability to convert testosterone (T) to a more potent androgen, dihydrotestosterone (DHT), and to convert progesterone and deoxycorticosterone (DOC) to their respective 5alpha-reduced ..
  25. ncbi 17beta-hydroxysteroid dehydrogenase type 1 stimulates breast cancer by dihydrotestosterone inactivation in addition to estradiol production
    Juliette A Aka
    Research Center of the Laval University Hospital Center CHUQ CHUL and Laval University, Quebec, Canada
    Mol Endocrinol 24:832-45. 2010
    The active estrogen estradiol (E2) stimulates breast cancer cell (BCC) growth, whereas the androgen dihydrotestosterone (DHT) has shown an antiproliferative effect...
  26. ncbi Uterine adenocarcinoma in mice following developmental treatment with estrogens: a model for hormonal carcinogenesis
    R R Newbold
    Developmental Endocrinology and Pharmacology Section, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709
    Cancer Res 50:7677-81. 1990
    ..The experimental induction of these tumors will provide the basis for additional studies in mechanisms of hormonal carcinogenesis...
  27. ncbi Dihydrotestosterone-inducible dickkopf 1 from balding dermal papilla cells causes apoptosis in follicular keratinocytes
    Mi Hee Kwack
    Department of Immunology, School of Medicine, Kyungpook National University, Daegu, Korea
    J Invest Dermatol 128:262-9. 2008
    ..Here, we screened dihydrotestosterone (DHT)-regulated genes in balding DP cells and found that dickkopf 1 (DKK-1) is one of the most upregulated ..
  28. ncbi A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy
    C W Gregory
    Laboratory for Reproductive Biology, Department of Pediatrics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Cancer Res 61:4315-9. 2001
    ..development and growth of prostate cancer depends on the androgen receptor and its high-affinity binding of dihydrotestosterone, which derives from testosterone...
  29. ncbi Insulin-like growth factor binding protein-3 is regulated by dihydrotestosterone and stimulates deoxyribonucleic acid synthesis and cell proliferation in LNCaP prostate carcinoma cells
    J L Martin
    Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St Leonards, New South Wales, Australia
    Endocrinology 141:2401-9. 2000
    ..Confluent monolayers of cells secreted approximately 0.7 ng/ml IGFBP-3 over 24 h. Dihydrotestosterone (DHT, 10 nM) and 1,25-dihydroxyvitamin D3 (vitamin D, 10 nM) increased IGFBP-3 in media to 149 +/- 15% and ..
  30. ncbi Testosterone's anti-anxiety and analgesic effects may be due in part to actions of its 5alpha-reduced metabolites in the hippocampus
    Kassandra L Edinger
    Department of Psychology, The University at Albany-SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Psychoneuroendocrinology 30:418-30. 2005
    ..that if T's anti-anxiety and analgesic effects are due in part to actions of its 5alpha-reduced metabolite (dihydrotestosterone-DHT) and/or its 3alpha-hydroxysteroid dehydrogenase reduced metabolite (3alpha-androstanediol-3alpha-diol), ..
  31. ncbi Differential regulation of rat testicular 5alpha-reductase type 1 and 2 isoforms by testosterone and FSH
    K Pratis
    Prince Henry s Institute of Medical Research, PO Box 5152, Clayton, Victoria 3168, Australia
    J Endocrinol 176:393-403. 2003
    Testosterone is metabolised to the more potent androgen, dihydrotestosterone, by the 5alpha-reductase (5alphaR) enzyme...
  32. ncbi Dihydrotestosterone may inhibit hypothalamo-pituitary-adrenal activity by acting through estrogen receptor in the male mouse
    Trent D Lund
    Department of Biomedical Sciences, Colorado State University, Anatomy W103, 1617 Campus Delivery, Fort Collins, CO 80523 1670, USA
    Neurosci Lett 365:43-7. 2004
    ..to environmental perturbation has been shown to be enhanced by estrogen but inhibited by the androgen dihydrotestosterone (DHT). However, the mechanism of androgen's action has not been identified...
  33. ncbi Atmospheric pressure photoionization tandem mass spectrometry of androgens in prostate cancer
    Fred Bjørn Lih
    National Institute of Environmental Health Sciences National Institutes of Health Department of Health and Human Services, Research Triangle Park, North Carolina 27709 2233, USA
    Anal Chem 82:6000-7. 2010
    ..Quantitation of the saturated keto-steroids dihydrotestosterone and 5-alpha-androstanedione required detection of a novel parent ion, [M + 15](+)...
  34. ncbi The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men
    Kishore M Lakshman
    Division of Endocrinology, Diabetes and Nutrition, Boston Claude D Pepper Older Americans Independence Center for Function Promoting Therapies, Boston University School of Medicine, Boston Medical Center, 670 Albany Street, Second Floor, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 95:3955-64. 2010
    During testosterone (T) therapy, T is partly converted to 17beta-estradiol (E2) and 5alpha-dihydrotestosterone (DHT). Effects of age, testosterone dose, and body composition on total and free E2 and DHT levels are unknown.
  35. ncbi Oxidative 3alpha-hydroxysteroid dehydrogenase activity of human type 10 17beta-hydroxysteroid dehydrogenase
    Xue Ying He
    Department of Pharmacology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    J Steroid Biochem Mol Biol 87:191-8. 2003
    ..catalyzes the oxidation of 5alpha-androstane-3alpha,17beta-diol (adiol), an almost inactive androgen, to dihydrotestosterone (DHT) rather than androsterone or androstanedione...
  36. ncbi Prx1 enhances androgen receptor function in prostate cancer cells by increasing receptor affinity to dihydrotestosterone
    Rishi Raj Chhipa
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Mol Cancer Res 7:1543-52. 2009
    ..In the present study, we evaluated the biological significance of Prx1 in modulating dihydrotestosterone (DHT)-stimulated growth and AR target gene expression of prostate cancer cells...
  37. ncbi Sex differences in brain and plasma beta-endorphin content following testosterone, dihydrotestosterone and estradiol administration to gonadectomized rats
    Nicola Pluchino
    Department of Reproductive Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Neuroendocrinology 89:411-23. 2009
    The present study aims at evaluating the effect of a 2-week treatment with testosterone (T), dihydrotestosterone (DHT) and estradiol valerate (E(2)V) on brain and plasma beta-endorphin (beta-END) concentrations in gonadectomized rats of ..
  38. ncbi The proliferative effects of 5-androstene-3 beta,17 beta-diol and 5 alpha-dihydrotestosterone on cell cycle analysis and cell proliferation in MCF7, T47D and MDAMB231 breast cancer cell lines
    S R Aspinall
    School of Surgery and Reproductive Sciences, The Medical School, University of Newcastle, Newcastle upon Tyne, Benton NE2 4HH, UK
    J Steroid Biochem Mol Biol 88:37-51. 2004
    ..In this study the proliferative affects of 5 alpha-dihydrotestosterone and 5-androstene-3 beta,17 beta-diol, which may be considered true metabolites acting at a tissue level, on ..
  39. ncbi Identification of the major oxidative 3alpha-hydroxysteroid dehydrogenase in human prostate that converts 5alpha-androstane-3alpha,17beta-diol to 5alpha-dihydrotestosterone: a potential therapeutic target for androgen-dependent disease
    David R Bauman
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6084, USA
    Mol Endocrinol 20:444-58. 2006
    Androgen-dependent prostate diseases initially require 5alpha-dihydrotestosterone (DHT) for growth...
  40. ncbi 5alpha-dihydrotestosterone (DHT) retards wound closure by inhibiting re-epithelialization
    S C Gilliver
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    J Pathol 217:73-82. 2009
    ..We previously demonstrated that blocking the conversion of testosterone to 5alpha-dihydrotestosterone (DHT) limits its ability to impair healing, suggesting that DHT is a more potent inhibitor of repair than ..
  41. ncbi Free testosterone and free dihydrotestosterone throughout the life span of men
    Luboslav Starka
    Steroid Hormones Dept, Institute of Endocrinology, Prague, Czech Republic
    J Steroid Biochem Mol Biol 116:118-20. 2009
    The dihydrotestosterone/testosterone ratio seems to be an important factor in the expression of androgenic activity, especially in the prostate and pilosebaceous unit...
  42. ncbi Epidermal-growth-factor-dependent phosphorylation and ubiquitinylation of MAGE-11 regulates its interaction with the androgen receptor
    Suxia Bai
    Laboratories for Reproductive Biology, CB 7500, University of North Carolina, Chapel Hill, NC 27599 7500, USA
    Mol Cell Biol 28:1947-63. 2008
    ..EGF in the presence of dihydrotestosterone stabilizes the AR-MAGE complex through the site-specific phosphorylation of MAGE-11 at Thr-360 and ..
  43. ncbi Differential effects of testosterone, dihydrotestosterone and estradiol on carotenoid deposition in an avian sexually selected signal
    Stefania Casagrande
    Behavioral Biology, Centre for Behavior and Neuroscience, University of Groningen, Haren, The Netherlands
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 197:1-13. 2011
    ..T can be converted to dihydrotestosterone (DHT) and estradiol (E2), and variation in conversion rate may partly explain some contradictory findings ..
  44. ncbi Dihydrotestosterone differentially modulates the cortisol response of the hypothalamic-pituitary-adrenal axis in male and female rhesus macaques, and restores circadian secretion of cortisol in females
    Donna J Toufexis
    Division of Developmental and Cognitive Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30322, USA
    Brain Res 1429:43-51. 2012
    ..male rhesus macaques, and replacement with sex-specific low and high physiological doses of dihydrotestosterone (DHT) in the same adult males as well as in adult, gonadally-suppressed, female rhesus macaques...
  45. ncbi The effect of dutasteride on intraprostatic dihydrotestosterone concentrations in men with benign prostatic hyperplasia
    R Wurzel
    Department of Urology, Grove Hill Medical Center, New Britain, CT 06052, USA
    Prostate Cancer Prostatic Dis 10:149-54. 2007
    The dual 5alpha-reductase inhibitor, dutasteride has been shown to suppress serum dihydrotestosterone (DHT) by >90%. In the present study, the effect of dutasteride 0.5 mg/day on intraprostatic DHT levels was investigated...
  46. ncbi Reexamination of testosterone, dihydrotestosterone, estradiol and estrone levels across the menstrual cycle and in postmenopausal women measured by liquid chromatography-tandem mass spectrometry
    Micol S Rothman
    Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    Steroids 76:177-82. 2011
    ..liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays to determine testosterone (T) and dihydrotestosterone (DHT) along with estradiol (E2) and estrone (E1) levels across the menstrual cycle of 31 healthy ..
  47. ncbi Dihydrotestosterone stimulates amino acid uptake and the expression of LAT2 in mouse skeletal muscle fibres through an ERK1/2-dependent mechanism
    M M Hamdi
    Biomedical and Clinical Sciences Research Institute, School of Medicine, Health Policy and Practice, University of East Anglia, Norwich NR4 7TJ, UK
    J Physiol 589:3623-40. 2011
    b>Dihydrotestosterone (DHT) has acute/non-genomic actions in adult mammalian skeletal muscles whose physiological functions are still poorly understood...
  48. ncbi Gonadal steroid attenuation of developing hamster facial motoneuron loss by axotomy: equal efficacy of testosterone, dihydrotestosterone, and 17-beta estradiol
    Christopher B Huppenbauer
    Department of Cell Biology, Neurobiology, and Anatomy, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois 60153, USA
    J Neurosci 25:4004-13. 2005
    ..The second half examines the neuroprotective effects of testosterone propionate, 17-beta estradiol, and dihydrotestosterone on FMNs of P7 hamsters after facial nerve transection at the SMF...
  49. ncbi Prostatic luminal cell differentiation and prostatic steroid-binding protein (PBP) gene expression are differentially affected by neonatal castration
    L Janulis
    Department of Urology, Northwestern University Medical School, Chicago, IL 60611, USA
    Prostate 43:195-204. 2000
    ..The purpose of this study was to examine the differentiation of prostatic epithelial cells after neonatal castration...
  50. ncbi Structural features discriminate androgen receptor N/C terminal and coactivator interactions
    Emily B Askew
    Laboratories for Reproductive Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 7500, USA
    Mol Cell Endocrinol 348:403-10. 2012
    ..We conclude that helix 12 residues outside the AF2 binding cleft modulate AR transcriptional activity by providing flexibility to accommodate FXXLF or LXXLL motif binding...
  51. ncbi Androgens and estrogens induce seasonal-like growth of song nuclei in the adult songbird brain
    Anthony D Tramontin
    Department of Neurosurgery Research, University of California, San Francisco, California 94143, USA
    J Neurobiol 57:130-40. 2003
    ..regressed song control nuclei were implanted with silastic capsules containing either crystalline T, 5alpha-dihydrotestosterone (DHT), estradiol (E(2)), or a combination of DHT+E(2). Control animals received empty implants...
  52. ncbi Regulation of the initial segment of the murine epididymis by dihydrotestosterone and testicular exocrine secretions studied by expression of specific proteins and gene expression
    C Avram
    Institut für Reproduktionsmedizin, Universitat Munster, Domagkstrasse 11, 48149, Germany
    Cell Tissue Res 317:13-22. 2004
    ..Administration of dihydrotestosterone (DHT) to the castrates maintained the proximal and distal caput epithelia and induced a proximal epithelium,..
  53. ncbi Lack of antiandrogenic effects in adult male rats following acute exposure to 2,2-bis(4-chlorophenyl)-1,1-dichloroethylene (p,p'-DDE)
    Teresa L Leavens
    Curriculum in Toxicology, University of North Carolina, Chapel Hill, USA
    Toxicology 174:69-78. 2002
    ..Testosterone and dihydrotestosterone were measured in serum...
  54. ncbi Testosterone decreases reactive astroglia and reactive microglia after brain injury in male rats: role of its metabolites, oestradiol and dihydrotestosterone
    George Barreto
    Instituto Cajal, C S I C, Madrid, Spain
    Eur J Neurosci 25:3039-46. 2007
    ..we have assessed the effect of early and late therapy with testosterone or its metabolites, oestradiol and dihydrotestosterone, on reactive astroglia and reactive microglia after a stab wound brain injury in orchidectomized Wistar ..
  55. ncbi 5Alpha-dihydrotestosterone up-regulates transthyretin levels in mice and rat choroid plexus via an androgen receptor independent pathway
    T Quintela
    Health Sciences Research Centre CICS, University of Beira Interior, Av Infante D Henrique, 6200 506 Covilha, Portugal
    Brain Res 1229:18-26. 2008
    ..In this study we examined the effects of 5alpha-dihydrotestosterone (DHT) on TTR protein and mRNA levels, in primary cultures of rat CPs epithelial cells (CPEC) by Western ..
  56. ncbi 1,25(OH)2D3 and dihydrotestosterone interact to regulate proliferation and differentiation of epiphyseal chondrocytes
    K Krohn
    Department of Nutrition and Inborn Errors of Metabolism, University Children's Hospital, Munich D-80337, Germany
    Calcif Tissue Int 73:400-10. 2003
    ..We investigated possible interactions of 1,25(OH)2D3 and the non-aromatizable androgen dihydrotestosterone (DHT) in primary chondrocyte cultures from young male rats...
  57. ncbi Impaired dihydrotestosterone catabolism in human prostate cancer: critical role of AKR1C2 as a pre-receptor regulator of androgen receptor signaling
    Qing Ji
    Department of Medicine, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    Cancer Res 67:1361-9. 2007
    ..We now report that dihydrotestosterone (DHT) levels are significantly greater in prostate cancer tumors compared with their paired benign tissues...
  58. ncbi Effect of dihydrotestosterone on hydrogen peroxide-induced apoptosis of mouse embryonic stem cells
    Sang Hun Lee
    Department of Veterinary Physiology, BK21 Biotherapy Human Resources Center, College of Veterinary Medicine, Chonnam National University, Gwangju 500 757, Korea
    J Cell Physiol 216:269-75. 2008
    ..Therefore, using mouse embryonic stem (ES) cells as a model system, this study evaluated the effects of dihydrotestosterone (DHT), a biologically active testosterone metabolite, on H2O2-induced apoptosis...
  59. ncbi Effects of steroid hormones on spermatogenesis and GnRH release in male Leopard frogs, Rana pipiens
    Pei San Tsai
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309 0354, USA
    Gen Comp Endocrinol 134:330-8. 2003
    ..suggest reproduction in the ranid frogs is potently regulated by the gonadal steroids, in particular 5alpha-dihydrotestosterone (DHT) and 17beta-estradiol (E(2)), and a non-gonadal steroid, the stress hormone corticosterone (Cort)...
  60. ncbi Transcriptomic characterization of the long-term dihydrotestosterone effects in adipose tissue
    Carl Bolduc
    Functional Genomics Laboratory, Molecular Endocrinology and Oncology Research Center, Laval University Medical Center, 2705 Boulevard Laurier, Quebec City, Quebec, G1V 4G2 Canada
    Obesity (Silver Spring) 15:1107-32. 2007
    To study the long-term transcriptomic effects of dihydrotestosterone (DHT) in adipose tissue. Fat distribution is regulated by sexual hormones. It is still unclear if androgens are promoting or reducing intra-abdominal fat accumulation.
  61. ncbi Proteomics of rat prostate lobes treated with 2-N-hydroxylamino-1-methyl-6-phenylimidazo[4,5-b]pyridine, 5alpha-dihydrotestosterone, individually and in combination
    Telih Boyiri
    Department of Biochemistry and Molecular Biology and Penn State Cancer Institute, Penn State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Int J Oncol 35:559-67. 2009
    ....
  62. ncbi 5alpha-reductase isozymes and aromatase are differentially expressed and active in the androgen-independent human prostate cancer cell lines DU145 and PC3
    P Negri-Cesi
    Center for Endocrinological Oncology, Department of Endocrinology, University of Milan, Milan, Italy
    Prostate 41:224-32. 1999
    ..17-keto androgens); and 2) to analyze whether one or both the two known 5alpha-reductase isoforms (5alpha-R1 and 5alpha-R2) and the aromatase (Aro) are expressed and active in this pathology...
  63. ncbi Testosterone, not 5α-dihydrotestosterone, stimulates LRH-1 leading to FSH-independent expression of Cyp19 and P450scc in granulosa cells
    Yan Guang Wu
    Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Mol Endocrinol 25:656-68. 2011
    ..T can be converted into estradiol, a classical estrogen, by Cyp19 and into 5α-dihydrotestosterone, a pure androgen, by 5α-reductase...
  64. ncbi Postnatal testosterone exposure results in insulin resistance, enlarged mesenteric adipocytes, and an atherogenic lipid profile in adult female rats: comparisons with estradiol and dihydrotestosterone
    Camilla Alexanderson
    Institute of Neuroscience and Physiology, Department of Physiology Endocrinology, Sahlgrenska Academy, Goteborg University, Box 434, 405 30, Goteborg, Sweden
    Endocrinology 148:5369-76. 2007
    ..in these programming effects, we compared testosterone-exposed rats to rats exposed to estradiol or dihydrotestosterone (DHT)...
  65. ncbi Human androgen receptor mutation disrupts ternary interactions between ligand, receptor domains, and the coactivator TIF2 (transcription intermediary factor 2)
    J Lim
    Department of Obstetrics and Gynecology, National University of Singapore, Republic of Singapore
    Mol Endocrinol 14:1187-97. 2000
    ..Mesterolone, but not the physiological androgen dihydrotestosterone, restored mutant LBD interactions with the TAD and with TIF2, when expressed as fusion proteins in the two-..
  66. ncbi 5alpha-dihydrotestosterone inhibits 1alpha,25-dihydroxyvitamin D3-induced expression of CYP24 in human prostate cancer cells
    Yan Ru Lou
    Department of Anatomy, Medical School, University of Tampere, Finland
    Prostate 63:222-30. 2005
    A cross-talk between 1alpha,25-dihydroxyvitamin D(3) [1alpha,25-(OH)(2)D(3)] and 5alpha-dihydrotestosterone (DHT) in the growth inhibition has been demonstrated, but the mechanism is unknown.
  67. ncbi Androgen metabolism in the prostate of the finasteride-treated, adult rat: a possible explanation for the differential action of testosterone and 5 alpha-dihydrotestosterone during development of the male urogenital tract
    F W George
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235 8857, USA
    Endocrinology 138:871-7. 1997
    Previous work has clearly demonstrated that inhibition of 5 alpha-dihydrotestosterone (DHT) formation in vivo is not as effective as total androgen ablation (castration) in causing involution of the prostate...
  68. ncbi Dihydrotestosterone and the prostate: the scientific rationale for 5alpha-reductase inhibitors in the treatment of benign prostatic hyperplasia
    Gerald Andriole
    Division of Urological Surgery, Washington University in St. Louis, St. Louis, Missouri 63110, USA
    J Urol 172:1399-403. 2004
    PURPOSE: We reviewed the physiological and pathogenic role of dihydrotestosterone (DHT), evidence for the beneficial effects of decreasing DHT through 5alpha-reductase inhibition and the effects of altering the androgen balance with ..
  69. ncbi Three weeks of creatine monohydrate supplementation affects dihydrotestosterone to testosterone ratio in college-aged rugby players
    Johann van der Merwe
    Department of Physiological Sciences, Stellenbosch University, Stellenbosch, South Africa
    Clin J Sport Med 19:399-404. 2009
    ..It was hypothesized that the ratio of dihydrotestosterone (DHT, a biologically more active androgen) to testosterone (T) would change with creatine supplementation.
  70. ncbi Hypothalamic neuroendocrine functions in rats with dihydrotestosterone-induced polycystic ovary syndrome: effects of low-frequency electro-acupuncture
    Yi Feng
    Institute of Neuroscience and Physiology, Department of Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 4:e6638. 2009
    ..Repeated low-frequency EA normalized estrous cyclicity and restored GnRH and AR protein expression. These results may help explain the beneficial neuroendocrine effects of low-frequency EA in women with PCOS...
  71. ncbi Partitioning of 5alpha-dihydrotestosterone and 5alpha-androstane-3alpha, 17beta-diol activated pathways for stimulating human prostate cancer LNCaP cell proliferation
    Eva H Nunlist
    Department of Urology, University of Oklahoma Health Sciences Center, 920 Stanton L. Young Blvd, WP3150, Oklahoma City, OK 73104, USA
    J Steroid Biochem Mol Biol 91:157-70. 2004
    ..Despite our understanding of molecular actions of 5alpha-dihydrotestosterone (5alpha-DHT) in the prostate through the trans-activation of the androgen receptor (AR), comprehensive ..
  72. ncbi Isoflavone supplements stimulated the production of serum equol and decreased the serum dihydrotestosterone levels in healthy male volunteers
    M Tanaka
    Department of Urology, Nara Medical University, Kashihara, Japan
    Prostate Cancer Prostatic Dis 12:247-52. 2009
    ..of sex hormone-binding globulin significantly increased, and the serum levels of free testosterone and dihydrotestosterone (DHT) decreased significantly after 3-month supplementation...
  73. ncbi 17beta-estradiol, progesterone, and dihydrotestosterone suppress the growth of human melanoma by inhibiting interleukin-8 production
    N Kanda
    Department of Dermatology, Teikyo University, School of Medicine, Itabashi ku, Tokyo, Japan
    J Invest Dermatol 117:274-83. 2001
    We studied the effects of 17beta-estradiol, progesterone, and dihydrotestosterone on in vitro growth of human metastatic melanoma...
  74. ncbi The role of dihydrotestosterone in benign prostatic hyperplasia
    Culley Carson
    Division of Urology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7235, USA
    Urology 61:2-7. 2003
    This article examines the role of the androgen dihydrotestosterone (DHT) in the healthy and diseased prostate and considers the implications of the data on DHT for therapeutic approaches to benign prostatic hyperplasia (BPH)...
  75. ncbi Dynamic expression of caspase-2, -3, -8, and -9 proteins and enzyme activity, but not messenger ribonucleic acid, in the monkey corpus luteum during the menstrual cycle
    Marina C Peluffo
    Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, Oregon 97006, USA
    J Clin Endocrinol Metab 90:2327-35. 2005
    ..The increased caspase activity at mid-late stage suggests that apoptosis is involved in early luteolysis in primates. Gonadotropin, perhaps via local steroids, modulates initiator caspases in the primate CL...
  76. ncbi Testosterone, but not nonaromatizable dihydrotestosterone, improves working memory and alters nerve growth factor levels in aged male rats
    Heather A Bimonte-Nelson
    Department of Physiology and Neuroscience and the Center for Studies on Aging, Medical University of South Carolina, Charleston 29425, USA
    Exp Neurol 181:301-12. 2003
    ..We treated aged male rats with either testosterone or dihydrotestosterone (DHT), the latter of which is not aromatized to estrogen, in order to determine whether these treatments ..
  77. ncbi Cognitive changes associated with supplementation of testosterone or dihydrotestosterone in mildly hypogonadal men: a preliminary report
    Monique M Cherrier
    Department of Psychiatry and Behavioral Sciences, University of Washington Medical School, Seattle, Washington 98108, USA
    J Androl 24:568-76. 2003
    ..examined changes in cognition in hypogonadal men given testosterone (T) or older hypogonadal men given dihydrotestosterone (DHT) gel...
  78. ncbi Tumor localization of 16beta-18F-fluoro-5alpha-dihydrotestosterone versus 18F-FDG in patients with progressive, metastatic prostate cancer
    Steven M Larson
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Nucl Med 45:366-73. 2004
    ..trial was an initial assessment of the feasibility, in vivo targeting, and biokinetics of 16beta-(18)F-fluoro-5alpha-dihydrotestosterone ((18)F-FDHT) PET in patients with metastatic prostate cancer to assess androgen receptor expression.
  79. ncbi Androgen receptor-dependent PSA expression in androgen-independent prostate cancer cells does not involve androgen receptor occupancy of the PSA locus
    Li Jia
    Department of Urology and Preventive Medicine, Norris Cancer Center, USC Keck School of Medicine, Los Angeles, California 90089, USA
    Cancer Res 65:8003-8. 2005
    ..The addition of dihydrotestosterone to the culture medium increased the expression of both genes in both cell types...
  80. ncbi The Estradiol-Dihydrotestosterone model of prostate cancer
    A Edward Friedman
    Department of Mathematics, University of Chicago, 5734 S, University Avenue, Chicago, IL 60637, USA
    Theor Biol Med Model 2:10. 2005
    ..This article proposes a theory which resolves this apparent paradox. MODEL: The Estradiol-Dihydrotestosterone(E-D) model introduced in this paper proposes that 17beta-estradiol(E2) is essential for initiating the ..
  81. ncbi Feedback inhibition of steroidogenic acute regulatory protein expression in vitro and in vivo by androgens
    Christopher P Houk
    Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Endocrinology 145:1269-75. 2004
    ..androgen receptor antagonist, enhanced StAR mRNA expression when added to cAMP-treated MA-10 cells, whereas dihydrotestosterone, a potent androgen receptor agonist, attenuated these responses...
  82. ncbi Endogenous coactivator ARA70 interacts with estrogen receptor alpha (ERalpha) and modulates the functional ERalpha/androgen receptor interplay in MCF-7 cells
    Marilena Lanzino
    Department of Pharmacobiology, University of Calabria, 87036 Arcavacata di Rende CS, Italy
    J Biol Chem 280:20421-30. 2005
    ..Thus, ARA70 is a coactivator for ERalpha and may represent a functional link between ERalpha/AR modulating their cross-talk in models of estrogen signaling in MCF-7 and HeLa cells...
  83. ncbi Xenoestrogen action in prostate cancer: pleiotropic effects dependent on androgen receptor status
    Yelena B Wetherill
    Department of Cell Biology and Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Cancer Res 65:54-65. 2005
    ..Moreover, in vitro radioligand binding assay revealed that BPA alters 5alpha-dihydrotestosterone binding to AR-T877A likely through noncompetitive inhibition...
  84. ncbi Equol is a novel anti-androgen that inhibits prostate growth and hormone feedback
    Trent D Lund
    Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80524, USA
    Biol Reprod 70:1188-95. 2004
    ..Using binding assays, we determined that equol specifically binds 5alpha-dihydrotestosterone (DHT), but not testosterone, dehydroepiandrosterone, or estrogen with high affinity...
  85. ncbi Deleterious effects of dihydrotestosterone on cerebral ischemic injury
    Jian Cheng
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Cereb Blood Flow Metab 27:1553-62. 2007
    ..The present study determined if the potent and nonaromatizable androgen, dihydrotestosterone (DHT), exacerbates ischemic damage in the male rat and alters postischemic gene expression after middle ..
  86. ncbi Sex steroids and all-cause and cause-specific mortality in men
    Andre B Araujo
    New England Research Institutes, 9 Galen St, Watertown, MA 02472, USA
    Arch Intern Med 167:1252-60. 2007
    ..Sex steroid levels are related to metabolic outcomes that could convey higher risk of premature death...
  87. ncbi Inhibition of the dihydrotestosterone-activated androgen receptor by nuclear receptor corepressor
    Shinta Cheng
    Cancer Biology Program, Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Endocrinol 16:1492-501. 2002
    ..This report demonstrates that NCoR interacts directly with the androgen receptor (AR) and represses dihydrotestosterone-stimulated AR transcriptional activity...
  88. ncbi Dihydrotestosterone activates sexual behavior in adult male hamsters but not in juveniles
    R D Romeo
    Department of Psychology, Neuroscience Program, Michigan State University, 48824, East Lansing, MI, USA
    Physiol Behav 73:579-84. 2001
    The effect of an androgenic metabolite of testosterone, dihydrotestosterone (DHT), on reproductive behavior and brain androgen receptor (AR) immunoreactivity was compared in juvenile and adult male Syrian hamsters...
  89. ncbi Testosterone and 5 alpha-dihydrotestosterone inhibit in vitro growth of human breast cancer cell lines
    J Ortmann
    Department of Obstetrics and Gynecology, Division of Gynecological Endocrinology and Reproductive Medicine, , Heidelberg, Germany
    Gynecol Endocrinol 16:113-20. 2002
    ..In the present study, we investigated the relationship between AR status and testosterone and 5 alpha-dihydrotestosterone (DHT)-dependent proliferation of the human breast carcinoma cell lines MCF-7, T47-D, MDA-MB 435S and BT-20...
  90. ncbi A double-blind, placebo-controlled, randomized clinical trial of transdermal dihydrotestosterone gel on muscular strength, mobility, and quality of life in older men with partial androgen deficiency
    L P Ly
    Department of Andrology, Concord Hospital, Concord, New South Wales 2139, Australia
    J Clin Endocrinol Metab 86:4078-88. 2001
    ..b>Dihydrotestosterone is the highest potency natural androgen with the additional features that it is neither aromatizable nor ..
  91. ncbi Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone
    J S Sack
    Bristol-Myers Squibb Pharmaceutical Research Institute, P.O. Box 4000, Princeton, NJ 08543-4000, USA
    Proc Natl Acad Sci U S A 98:4904-9. 2001
    ..wild-type androgen receptor (AR) and the T877A mutant corresponding to that in LNCaP cells, both bound to dihydrotestosterone, have been refined at 2.0 A resolution...
  92. ncbi Increased ovulation rate in gilts treated with dihydrotestosterone
    H Cardenas
    Department of Animal Sciences, The Ohio State University, 2029 Coffey Road, Columbus, OH 43210, USA
    Reproduction 123:527-33. 2002
    ..The present study was conducted to examine the effects of 5alpha-dihydrotestosterone (DHT), a non-aromatizable androgen receptor ligand, on ovulation rate and amounts of androgen receptor and ..
  93. ncbi Testosterone, androstenedione and dihydrotestosterone concentrations are elevated in female patients with major depression
    B Weber
    Central Institute of Mental Health, PO Box 122120, 68072, Mannheim, Germany
    Psychoneuroendocrinology 25:765-71. 2000
    ..To date, there is only sparse information about the regulation of androstenedione, testosterone and dihydrotestosterone (DHT) concentrations in women with severe major depression...
  94. ncbi Dihydrotestosterone and estrogen regulation of rat brain androgen-receptor immunoreactivity
    C S Lynch
    Department of Psychology, University of Louisiana, P O Box 43131, Lafayette, LA 70504, USA
    Physiol Behav 69:445-53. 2000
    ..that occurs with androgenic-anabolic steroid (AAS) administration may be mediated by AAS metabolites, dihydrotestosterone (DHT), and estrogen. Castrated and intact male rats received 14 s.c...
  95. ncbi Dihydrotestosterone treatment in adolescents with delayed puberty: does it explain insulin resistance of puberty?
    R J Saad
    Children s Hospital of Pittsburgh, 3705 Fifth Avenue at DeSoto Street, Pittsburgh, PA 15213, USA
    J Clin Endocrinol Metab 86:4881-6. 2001
    ..The present investigation evaluated the effects of 4 months of dihydrotestosterone administration (50 mg im every 2 wk) on body composition, glucose, fat, and protein metabolism, and insulin ..
  96. ncbi Simultaneous measurement of serum testosterone and dihydrotestosterone by liquid chromatography-tandem mass spectrometry
    Steve Shiraishi
    General Clinical Research Center, Division of Endocrinology and Metabolism, Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, CA 90509, USA
    Clin Chem 54:1855-63. 2008
    ..Recent reports have described inherent problems with androgen immunoassays compared with mass spectrometry analyses...
  97. ncbi The effect of allelic variation in aldo-keto reductase 1C2 on the in vitro metabolism of dihydrotestosterone
    Ryan H Takahashi
    Division of Pharmaceutics and Biopharmaceutics, Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 East Mall, Vancouver, BC, Canada V6T 1Z3
    J Pharmacol Exp Ther 329:1032-9. 2009
    ..1C2 is a human, cytosolic enzyme that has an important role in the deactivation of the potent androgen dihydrotestosterone (DHT)...
  98. ncbi The expression of the ADAMs proteases in prostate cancer cell lines and their regulation by dihydrotestosterone
    D R McCulloch
    Centre for Molecular Biotechnology, School of Life Sciences, Queensland University of Technology, Queensland 4000, Brisbane, Australia
    Mol Cell Endocrinol 167:11-21. 2000
    ..Since androgens are implicated in prostate cancer cell growth and maintenance, the regulation of ADAMs by dihydrotestosterone (DHT) was investigated in the androgen-dependent cell line LNCaP...
  99. ncbi Adrenal and gonadal steroids inhibit IL-6 secretion by human marrow cells
    C M Gordon
    Division of Adolescent Young Adult Medicine, Children s Hospital, Boston, MA 02115, USA
    Cytokine 16:178-86. 2001
    ..marrow cells and a line of marrow stromal cells (KM101) is inhibited by dehydroepiandrosterone (DHEA), dihydrotestosterone (DHT) and 17beta-oestradiol (E(2))...
  100. ncbi Reciprocal regulation of 5alpha-dihydrotestosterone, interleukin-6 and interleukin-8 during proliferation of epithelial ovarian carcinoma
    Yue Wang
    Department of Immunology, Tianjin Medical University, Tianjin, PR, China
    Cancer Biol Ther 6:864-71. 2007
    ..In these studies, the effect of 5alpha-dihydrotestosterone (DHT) on the expression levels of IL-6 and IL-8 was investigated...
  101. ncbi Dihydrotestosterone inhibits granulosa cell proliferation by decreasing the cyclin D2 mRNA expression and cell cycle arrest at G1 phase
    P K Pradeep
    Department of Obstetrics and Gynecology, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA
    Endocrinology 143:2930-5. 2002
    ..In the present study, we examined the molecular mechanism by which dihydrotestosterone (DHT), a 5alpha reduced metabolite of testosterone, mediates the inhibition of granulosa cell proliferation,..

Research Grants77

  1. Role of 5-alpha Reductase in Testosterone Actions
    Shalendar Bhasin; Fiscal Year: 2007
    ..as a prohormone that is converted in the body to two active metabolites, estradiol 17beta and 5-alpha dihydrotestosterone (DHT)...
  2. PROGESTERONE RECEPTOR AND ACTION IN THE PRIMATE OVARY
    Richard Stouffer; Fiscal Year: 2007
    ..a 3p-hydroxysteroid dehydrogenase inhibitor) and P (R5020) or other steroid (estrogen, R2858 or androgen, dihydrotestosterone) replacements...
  3. PROGESTERONE RECEPTOR AND ACTION IN THE PRIMATE OVARY
    Richard Stouffer; Fiscal Year: 2009
    ..a 3p-hydroxysteroid dehydrogenase inhibitor) and P (R5020) or other steroid (estrogen, R2858 or androgen, dihydrotestosterone) replacements...
  4. PROGESTERONE RECEPTOR AND ACTION IN THE PRIMATE OVARY
    Richard L Stouffer; Fiscal Year: 2010
    ..a 3p-hydroxysteroid dehydrogenase inhibitor) and P (R5020) or other steroid (estrogen, R2858 or androgen, dihydrotestosterone) replacements...
  5. FREE PLASMA SEX HORMONE AND ANDROGEN ACTION
    Robert Rosenfield; Fiscal Year: 1980
    ..be developed for the measurement of the major plasma androgens--the 17 beta-hydroxysteroids (testosterone, dihydrotestosterone, delta 5-androstenediol, and 3 alpha/3 beta-androstanediols) and 17-ketosteroids (androstenedione and ..
  6. Impact of Puberty on the Kidney in Diabetes
    PASCALE LANE; Fiscal Year: 2005
    ..the role of the androgen receptor in the renal response to DM; and 5)Determine whether conversion to dihydrotestosterone is necessary for the post-pubertal renal response to STZ DM...
  7. Maintainance of Organ Function Following Injury
    Irshad Chaudry; Fiscal Year: 2007
    Our recent studies indicate that depletion of androgens (testosterone and dihydrotestosterone) two weeks prior to onset of hemorrhage prevents the depression of cardiac function following trauma-hemorrhage and resuscitation...
  8. HORMONAL REGULATION OF ETHANOL METABOLISM
    Esteban Mezey; Fiscal Year: 2000
    ..Alcohol dehydrogenase is increased by growth hormone and suppressed by dihydrotestosterone. Glucagon and epinephrine enhance alcohol dehydrogenase and this effect is most likely mediated by cAMP...
  9. PROSTATIC DIFFERENTIATION AND SEX HORMONE METABOLISM
    Shuk Mei Ho; Fiscal Year: 2007
    ..T, 5alpha-dihydrotestosterone (DHT), PRL and E2 were shown to exert different proliferation- and dysplasia-promoting actions on explants ..
  10. Equol and Regulation of Prostate Growth
    Robert J Handa; Fiscal Year: 2010
    ..circulating testosterone;inhibition of 5-alpha reductase, an enzyme that synthesizes the potent androgen, dihydrotestosterone;or blocking the actions of the androgen receptor...
  11. Androgen Receptor Function in Prostate Cancer
    Richard G Pestell; Fiscal Year: 2010
    ..AR acetylation and phosphorylation are linked, 2. SirT1 expression and function are regulated by dihydrotestosterone (DHT) and metabolism 3. AR is repressed by the NAD-dependent histone deacetylases (SirT1), and 4...
  12. Equol and Regulation of Prostate Growth
    Robert Handa; Fiscal Year: 2009
    ..circulating testosterone; inhibition of 5-alpha reductase, an enzyme that synthesizes the potent androgen, dihydrotestosterone; or blocking the actions of the androgen receptor...
  13. A Novel Synthetic Androgen Receptor Antagonist
    Zhongyun Dong; Fiscal Year: 2010
    ..DL3 inhibits dihydrotestosterone (DHT)-stimulated cell growth and gene expression in all prostate cancer cell lines tested, including ..
  14. Estrogen Metabolism and Action in Prostate Cancer Etiology in PCPT
    Ashraful Hoque; Fiscal Year: 2007
    ..inhibitor finasteride (versus placebo) found that inhibiting SRD5A2 from converting testosterone into dihydrotestosterone reduced total prostate cancer risk by 25%, but also increased the risk of high-grade cancer...
  15. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad Chaudry; Fiscal Year: 2006
    ..Studies also show that increased 5alpha-dihydrotestosterone synthesis in T cells is the likely cause for immune depression in males, while continued E2 synthesis ..
  16. Mechanisms of Testosterone Effects on Body Composition
    Shalendar Bhasin; Fiscal Year: 2007
    ..We hypothesize that testosterone and dihydrotestosterone (DHT), two prototypical androgens, promote the differentiation of adult, pluripotent mesenchymal stem cells ..
  17. Testosterone:Physical Function in Men on Hemodialysis
    Shalender Bhasin; Fiscal Year: 2004
    ..Total and free testosterone and dihydrotestosterone levels will be measured as markers of androgen bioavailability, and LH, FSH, and SHBG as markers of ..
  18. In vivo effects of sulforaphane supplementation on normal human prostate
    DANIEL W contact LIN; Fiscal Year: 2010
    ..and reduces oxidative damage in human prostate and (2) increases DHT catabolism and reduces intra-prostatic dihydrotestosterone (DHT) concentration...