bacitracin

Summary

Summary: A complex of cyclic peptide antibiotics produced by the Tracy-I strain of Bacillus subtilis. The commercial preparation is a mixture of at least nine bacitracins with bacitracin A as the major constituent. It is used topically to treat open infections such as infected eczema and infected dermal ulcers. (From Goodman and Gilman, The Pharmacological Basis of Therapeutics, 8th ed, p1140)

Top Publications

  1. ncbi Topical triple-antibiotic ointment as a novel therapeutic choice in wound management and infection prevention: a practical perspective
    Robert A Bonomo
    Case Western Reserve University, Veteran Affairs Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
    Expert Rev Anti Infect Ther 5:773-82. 2007
  2. pmc Generic and specific adaptive responses of Streptococcus pneumoniae to challenge with three distinct antimicrobial peptides, bacitracin, LL-37, and nisin
    Joanna A Majchrzykiewicz
    Department of Molecular Genetics, University of Groningen, Groningen Biomolecular Sciences and Biotechnology Institute, P O Box 14, 9750 AA Haren, The Netherlands
    Antimicrob Agents Chemother 54:440-51. 2010
  3. pmc The BceABRS four-component system regulates the bacitracin-induced cell envelope stress response in Streptococcus mutans
    Jing Ouyang
    Department of Applied Oral Sciences, Dalhousie University, Halifax, Nova Scotia, Canada B3H 3J5
    Antimicrob Agents Chemother 54:3895-906. 2010
  4. ncbi Nebulized bacitracin/colimycin: a treatment option in recalcitrant chronic rhinosinusitis with Staphylococcus aureus? A double-blind, randomized, placebo-controlled, cross-over pilot study
    W J M Videler
    Dept of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Rhinology 46:92-8. 2008
  5. pmc Peptide antibiotic sensing and detoxification modules of Bacillus subtilis
    Anna Staron
    Ludwig Maximilians University, Department Biology I, Microbiology, Munich, Germany
    Antimicrob Agents Chemother 55:515-25. 2011
  6. ncbi Two-component system VraSR positively modulates the regulation of cell-wall biosynthesis pathway in Staphylococcus aureus
    Makoto Kuroda
    Bacteriology, Juntendo University, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Mol Microbiol 49:807-21. 2003
  7. pmc Genes involved in bacitracin resistance in Streptococcus mutans
    Hiromasa Tsuda
    Department of Preventive Dentistry, Kyushu University Faculty of Dental Science, Fukuoka 812 8582, Japan
    Antimicrob Agents Chemother 46:3756-64. 2002
  8. pmc Bacitracin-resistant clone of Streptococcus pyogenes isolated from pharyngitis patients in Belgium
    Surbhi Malhotra-Kumar
    Department of Microbiology, University of Antwerp UIA, Antwerp, Belgium
    J Clin Microbiol 41:5282-4. 2003
  9. pmc Acquired bacitracin resistance in Enterococcus faecalis is mediated by an ABC transporter and a novel regulatory protein, BcrR
    Janet M Manson
    Department of Microbiology and Immunology, Otago School of Medical Sciences, University of Otago, P O Box 56, Dunedin, New Zealand
    Antimicrob Agents Chemother 48:3743-8. 2004
  10. pmc The ABC transporter AnrAB contributes to the innate resistance of Listeria monocytogenes to nisin, bacitracin, and various beta-lactam antibiotics
    Barry Collins
    Department of Microbiology, University College Cork, Cork, Ireland
    Antimicrob Agents Chemother 54:4416-23. 2010

Detail Information

Publications230 found, 100 shown here

  1. ncbi Topical triple-antibiotic ointment as a novel therapeutic choice in wound management and infection prevention: a practical perspective
    Robert A Bonomo
    Case Western Reserve University, Veteran Affairs Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
    Expert Rev Anti Infect Ther 5:773-82. 2007
    ..The formulation contains neomycin, polymyxin B and bacitracin in a petrolatum base...
  2. pmc Generic and specific adaptive responses of Streptococcus pneumoniae to challenge with three distinct antimicrobial peptides, bacitracin, LL-37, and nisin
    Joanna A Majchrzykiewicz
    Department of Molecular Genetics, University of Groningen, Groningen Biomolecular Sciences and Biotechnology Institute, P O Box 14, 9750 AA Haren, The Netherlands
    Antimicrob Agents Chemother 54:440-51. 2010
    To investigate the response of Streptococcus pneumoniae to three distinct antimicrobial peptides (AMPs), bacitracin, nisin, and LL-37, transcriptome analysis of challenged bacteria was performed...
  3. pmc The BceABRS four-component system regulates the bacitracin-induced cell envelope stress response in Streptococcus mutans
    Jing Ouyang
    Department of Applied Oral Sciences, Dalhousie University, Halifax, Nova Scotia, Canada B3H 3J5
    Antimicrob Agents Chemother 54:3895-906. 2010
    Streptococcus mutans is known to be resistant to bacitracin, a cyclic polypeptide antibiotic produced by certain species of the genus Bacillus. This property is often exploited in the isolation of S...
  4. ncbi Nebulized bacitracin/colimycin: a treatment option in recalcitrant chronic rhinosinusitis with Staphylococcus aureus? A double-blind, randomized, placebo-controlled, cross-over pilot study
    W J M Videler
    Dept of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Rhinology 46:92-8. 2008
    ..We have performed a pilot study in order to determine whether nebulized topical antibiotic therapy improves sinusitis symptoms more than saline-based placebo in patients with recalcitrant chronic rhinosinusitis...
  5. pmc Peptide antibiotic sensing and detoxification modules of Bacillus subtilis
    Anna Staron
    Ludwig Maximilians University, Department Biology I, Microbiology, Munich, Germany
    Antimicrob Agents Chemother 55:515-25. 2011
    ..BceRS-BceAB (BceRS-AB) responds to bacitracin, plectasin, mersacidin, and actagardine. YxdJK-LM is induced by a cationic antimicrobial peptide, LL-37...
  6. ncbi Two-component system VraSR positively modulates the regulation of cell-wall biosynthesis pathway in Staphylococcus aureus
    Makoto Kuroda
    Bacteriology, Juntendo University, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Mol Microbiol 49:807-21. 2003
    ..aureus showed significant decrease of resistance against teicoplanin, beta-lactam, bacitracin and fosfomycin but not of D-cycloserine and levofloxacin...
  7. pmc Genes involved in bacitracin resistance in Streptococcus mutans
    Hiromasa Tsuda
    Department of Preventive Dentistry, Kyushu University Faculty of Dental Science, Fukuoka 812 8582, Japan
    Antimicrob Agents Chemother 46:3756-64. 2002
    Streptococcus mutans is resistant to bacitracin, which is a peptide antibiotic produced by certain species of Bacillus. The purpose of this study was to clarify the bacitracin resistance mechanism of S. mutans...
  8. pmc Bacitracin-resistant clone of Streptococcus pyogenes isolated from pharyngitis patients in Belgium
    Surbhi Malhotra-Kumar
    Department of Microbiology, University of Antwerp UIA, Antwerp, Belgium
    J Clin Microbiol 41:5282-4. 2003
    We report 16 bacitracin-resistant Streptococcus pyogenes isolates recovered from pharyngitis patients in Belgium, 14 of which belonged to a particular emm type (emm28)...
  9. pmc Acquired bacitracin resistance in Enterococcus faecalis is mediated by an ABC transporter and a novel regulatory protein, BcrR
    Janet M Manson
    Department of Microbiology and Immunology, Otago School of Medical Sciences, University of Otago, P O Box 56, Dunedin, New Zealand
    Antimicrob Agents Chemother 48:3743-8. 2004
    b>Bacitracin resistance (bacitracin MIC, >/=256 microg ml(-1)) has been reported in Enterococcus faecalis, and in the present study we report on the genetic basis for this resistance...
  10. pmc The ABC transporter AnrAB contributes to the innate resistance of Listeria monocytogenes to nisin, bacitracin, and various beta-lactam antibiotics
    Barry Collins
    Department of Microbiology, University College Cork, Cork, Ireland
    Antimicrob Agents Chemother 54:4416-23. 2010
    ..The loss of this putative multidrug resistance transporter also greatly enhanced sensitivity to bacitracin, gallidermin, and a selection of β-lactam antibiotics...
  11. ncbi Genome-wide transcriptional profiling of the response of Staphylococcus aureus to cell-wall-active antibiotics reveals a cell-wall-stress stimulon
    S Utaida
    Microbiology Group, Department of Biological Sciences, Illinois State University, Normal, IL 61791 4120, USA
    Microbiology 149:2719-32. 2003
    ..and stress responses (including msrA, htrA, psrA and hslO), were upregulated by oxacillin, D-cycloserine or bacitracin. This response may represent the transcriptional signature of a cell-wall stimulon induced in response to cell-..
  12. ncbi Bacitracin reveals a role for multiple thiol isomerases in platelet function
    Aisling Robinson
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Br J Haematol 132:339-48. 2006
    ..Using a highly purified form of bacitracin, a thiol isomerase inhibitor, we now provide further evidence of the functional significance of this enzymatic ..
  13. ncbi Effect of zinc bacitracin and salinomycin on intestinal microflora and performance of broilers
    R M Engberg
    Department of Animal Nutrition and Physiology, Danish Institute of Agricultural Sciences, Research Centre Foulum, Tjele
    Poult Sci 79:1311-9. 2000
    ..with four groups of broiler chickens fed experimental diets formulated to provide no supplementation, 20 mg zinc bacitracin, 60 mg salinomycin, or both feed additives in combination...
  14. ncbi The efficacy of bacitracin methylene disalicylate when fed in combination with narasin in the management of necrotic enteritis in broiler chickens
    J Brennan
    Maple Leaf Foods Agresearch, Burford, Ontario, Canada
    Poult Sci 82:360-3. 2003
    The efficacy of bacitracin methylene disalicylate (BMD) in the management of necrotic enteritis (NE) when fed in combination with narasin was investigated in a floor-pen study of 2,000 broiler chickens using a Clostridium perfringens ..
  15. ncbi Anaphylaxis to topical bacitracin ointment
    Karen Greenberg
    Emergency Medicine Department, University of Medicine and Dentistry of New Jersey, School of Osteopathic Medicine, Kennedy Health System Stratford Division, Stratford, NJ 08084, USA
    Am J Emerg Med 25:95-6. 2007
  16. pmc Regulation of the Bacillus subtilis bcrC bacitracin resistance gene by two extracytoplasmic function sigma factors
    Min Cao
    Department of Microbiology, Cornell University, Ithaca, New York 14853 8101, USA
    J Bacteriol 184:6123-9. 2002
    b>Bacitracin resistance is normally conferred by either of two major mechanisms, the BcrABC transporter, which pumps out bacitracin, or BacA, an undecaprenol kinase that provides C(55)-isoprenyl phosphate by de novo synthesis...
  17. pmc Antimicrobial susceptibility of Bacillus strains isolated from primary starters for African traditional bread production and characterization of the bacitracin operon and bacitracin biosynthesis
    David B Adimpong
    University of Copenhagen, Faculty of Science, Department of Food Science, Frederiksberg, Denmark
    Appl Environ Microbiol 78:7903-14. 2012
    ..The ermD and ermK genes were localized on an 11.4-kbp plasmid. All of the B. sonorensis strains harbored the bacitracin synthetase gene, bacA, and the transporter gene bcrA, which correlated with their observed resistance to ..
  18. pmc Resistance to bacitracin as modulated by an Escherichia coli homologue of the bacitracin ABC transporter BcrC subunit from Bacillus licheniformis
    Y M Harel
    Institut Curie, Batiment 110, Centre Universitaire, F 91405 Orsay, France
    J Bacteriol 181:6176-8. 1999
    ..reading frame from the Escherichia coli chromosome, bcrC(EC), encodes a homologue to the BcrC subunit of the bacitracin permease from Bacillus licheniformis...
  19. ncbi Pathways of chemical degradation of polypeptide antibiotic bacitracin
    Viljem Pavli
    Stability Testing Department, Krka d d, Novo mesto, Ljubljana, Slovenia
    Biol Pharm Bull 29:2160-7. 2006
    We described the main pathways of bacitracin (Bc) decomposition, chromatographically set the position of its major degradation products and evaluated microbiological activity of isolated components of Bc and its degradation products...
  20. ncbi The two-component regulatory system BacRS is associated with bacitracin 'self-resistance' of Bacillus licheniformis ATCC 10716
    A M Neumüller
    Philipps Universitat Marburg, FB Chemie Biochemie, Germany
    Eur J Biochem 268:3180-9. 2001
    b>Bacitracin is a peptide antibiotic produced by several Bacillus licheniformis strains that is most active against other Gram-positive microorganisms, but not against the producer strain itself...
  21. ncbi From road rash to top allergen in a flash: bacitracin
    Sharon E Jacob
    Department of Dermatology and Cutaneous Surgery, University of Miami, Miami, Florida
    Dermatol Surg 30:521-4. 2004
    b>Bacitracin is an antibiotic that is produced by Bacillus subtilis, which is used in several types of consumer products, including cosmetics and ophthalmic and cutaneous ointments.
  22. doi 1H NMR, mechanism, and mononuclear oxidative activity of the antibiotic metallopeptide bacitracin: the role of D-Glu-4, interaction with pyrophosphate moiety, DNA binding and cleavage, and bioactivity
    William M Tay
    Department of Chemistry and MBIG, University of South Florida, Tampa, Florida 33620 5250, USA
    J Am Chem Soc 132:5652-61. 2010
    The peptidyl antibiotic bacitracin (Bc) is one of the most widely used antibiotics which can bind divalent transition metal ions, including Mn(II), Co(II), Ni(II), Cu(II), and Zn(II)...
  23. ncbi Cell wall stress responses in Bacillus subtilis: the regulatory network of the bacitracin stimulon
    Thorsten Mascher
    Department of Microbiology, Cornell University, Ithaca, NY 14853 8101, USA
    Mol Microbiol 50:1591-604. 2003
    ..We report the response of Bacillus subtilis to bacitracin, an inhibitor of cell wall biosynthesis found in its natural environment...
  24. ncbi Anaphylactic reaction to bacitracin ointment
    Hyland Cronin
    Geisinger Health System, 100 N Academy Ave, MC 14 06, Danville, PA 17822, USA
    Cutis 83:127-9. 2009
    We report a case of an 11-year-old boy who experienced an anaphylactic reaction after administration of bacitracin ointment. After falling and scraping his left elbow, bacitracin ointment was applied to the wound...
  25. doi Bacitracin and nisin resistance in Staphylococcus aureus: a novel pathway involving the BraS/BraR two-component system (SA2417/SA2418) and both the BraD/BraE and VraD/VraE ABC transporters
    Aurelia Hiron
    Institut Pasteur, Biology of Gram Positive Pathogens, Department of Microbiology, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 81:602-22. 2011
    ..b>Bacitracin, a cyclic dodecylpeptide antibiotic, binds to undecaprenyl pyrophosphate, the lipid carrier for cell wall ..
  26. doi Bacitracin sensing and resistance in Staphylococcus aureus
    Yuuma Yoshida
    Department of Oral Microbiology, Kagoshima University Graduate School of Medical and Dental Sciences, Japan
    FEMS Microbiol Lett 320:33-9. 2011
    ..uncharacterized TCS (designated as BceRS, MW gene ID: MW2545-2544) resulted in an increase in susceptibility to bacitracin. In this study, we focused on this TCS and tried to identify the TCS-controlled factors affecting the ..
  27. pmc Antiviral propierties of 5,5'-dithiobis-2-nitrobenzoic acid and bacitracin against T-tropic human immunodeficiency virus type 1
    Humberto H Lara
    Laboratorio de Inmunología y Virología, Departamento de Microbiologia e Inmunologia, Universidad Autonoma de Nuevo Leon, San Nicolas de los Garza, Nuevo Leon, Mexico
    Virol J 8:137. 2011
    b>Bacitracin and the membrane-impermeant thiol reagent 5,5'-dithiobis-2-nitrobenzoic acid (DTNB) are agents known to inhibit protein disulfide isomerase (PDI), a cell-surface protein critical in HIV-1 entry therefore they are fusion ..
  28. doi Effects of zinc bacitracin, bird age and access to range on bacterial microbiota in the ileum and caeca of broiler chickens
    J Gong
    Guelph Food Research Centre, Agriculture and Agri Food Canada, Guelph, ON, Canada
    J Appl Microbiol 104:1372-82. 2008
    Determining the effects of zinc bacitracin, bird age and access to range on bacterial microbiota in the ileum and caeca of broilers.
  29. doi Study on the dissemination of the bcrABDR cluster in Enterococcus spp. reveals that the BcrAB transporter is sufficient to confer high-level bacitracin resistance
    Renata Matos
    Instituto de Biologia Experimental e Tecnológica Instituto de Tecnologia Química e Biológica, Oeiras, Portugal
    Int J Antimicrob Agents 34:142-7. 2009
    b>Bacitracin is used both in clinical practice and as an animal growth promoter in some countries. Recent reports revealed the dissemination of high-level bacitracin resistance (HLBR) in the genus Enterococcus...
  30. ncbi Detection of IgE antibodies to bacitracin using a commercially available streptavidin-linked solid phase in a patient with anaphylaxis to triple antibiotic ointment
    Saba Sharif
    Kaiser Permanente, Los Angeles Medical Center, Los Angeles, California, USA
    Ann Allergy Asthma Immunol 98:563-6. 2007
    b>Bacitracin is a commonly used topical antibiotic that has on occasion been reported to cause anaphylaxis. Evidence of the role of bacitracin specific IgE in such reactions has been demonstrated by skin testing...
  31. ncbi Protein disulfide isomerase suppresses the transcriptional activity of NF-kappaB
    Toshio Higuchi
    Pharmaceutical Frontier Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc, Yokohama, Kanagawa, Japan
    Biochem Biophys Res Commun 318:46-52. 2004
    ..This negative regulation of NF-kappaB was reversed by bacitracin, a PDI inhibitor...
  32. ncbi Bacitracin is not a specific inhibitor of protein disulfide isomerase
    Anna Riikka Karala
    Biocenter Oulu and Department of Biochemistry, University of Oulu, Oulu, Finland
    FEBS J 277:2454-62. 2010
    To successfully dissect molecular pathways in vivo, there is often a need to use specific inhibitors. Bacitracin is very widely used as an inhibitor of protein disulfide isomerase (PDI) in vivo...
  33. pmc An ABC transporter of Streptococcus pneumoniae involved in susceptibility to vancoresmycin and bacitracin
    Petra Becker
    Fachbereich Biologie, Abteilung Mikrobiologie, Technische Universitat Kaiserslautern, P O Box 3049, 67653 Kaiserslautern, Germany
    Antimicrob Agents Chemother 53:2034-41. 2009
    ..Due to the similarity of Spr0812-Spr0813 to bacitracin transporters of Streptococcus mutans and Bacillus spp...
  34. ncbi YtsCD and YwoA, two independent systems that confer bacitracin resistance to Bacillus subtilis
    Remi Bernard
    Laboratoire de Chimie Bacterienne, Institut de Biologie Structurale et Microbiologie, CNRS, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    FEMS Microbiol Lett 228:93-7. 2003
    ..tested for their sensitivity towards a series of antibiotics, null yts mutants were found to be sensitive to bacitracin. Real-time polymerase chain reaction (PCR) experiments demonstrated that the presence of bacitracin in the ..
  35. pmc A bacitracin-resistant Bacillus subtilis gene encodes a homologue of the membrane-spanning subunit of the Bacillus licheniformis ABC transporter
    Reiko Ohki
    Department of Molecular Biolog, School of Health Sciences, Kyorin University, 476 Miyashita, Hachioji, Tokyo 192 0005, Japan
    J Bacteriol 185:51-9. 2003
    b>Bacitracin is a peptide antibiotic nonribosomally produced by Bacillus licheniformis...
  36. doi Characterization of the mechanism of the Staphylococcus aureus cell envelope by bacitracin and bacitracin-metal ions
    Zu De Qi
    College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, People s Republic of China
    J Membr Biol 225:27-37. 2008
    b>Bacitracin is a metal-dependent dodecapeptide antipeptide produced by Bacillus species...
  37. ncbi Distribution and variation of bacitracin synthetase gene sequences in laboratory stock strains of Bacillus licheniformis
    Hiroaki Ishihara
    Faculty of Liberal Arts, Tohoku Gakuin University, Tenjinsawa 2 1 1, Izumi ku, Sendai 981 3193, Japan
    Curr Microbiol 45:18-23. 2002
    Distribution and variation of bacitracin synthetase gene (bac) sequences in 22 laboratory stock strains of Bacillus licheniformis were studied by Southern hybridization of bac gene probes from B...
  38. ncbi Influence of molecular dipoles on human skin permeability: Use of 6-ketocholestanol to enhance the transdermal delivery of bacitracin
    Josep Cladera
    School of Biomedical Sciences, Medical School, University of Nottingham, Nottingham NG 7 2UH, United Kingdom
    J Pharm Sci 92:1018-27. 2003
    ..Using fluorescein-labeled bacitracin and confocal microscopy, we show that the penetration of the antibiotic peptide bacitracin into the epidermis is ..
  39. pmc Protein disulfide-isomerase mediates delivery of nitric oxide redox derivatives into platelets
    Susannah E Bell
    Department of Biomedical Science, University of Westminster, 115 New Cavendish Street, London W1W 6UW, UK
    Biochem J 403:283-8. 2007
    ..These results further highlight the importance of PDI in mediating the action of a wide range of NO-related signals...
  40. pmc Amplification of the bacA gene confers bacitracin resistance to Escherichia coli
    B D Cain
    Department of Biochemistry and Molecular Biology, University of Florida, Gainesville 32610
    J Bacteriol 175:3784-9. 1993
    An Escherichia coli genomic library was constructed in order to facilitate selection for genes which confer bacitracin resistance through amplification...
  41. pmc Resistance to bacitracin in Bacillus subtilis: unexpected requirement of the BceAB ABC transporter in the control of expression of its own structural genes
    Remi Bernard
    Laboratoire de Chimie Bacterienne, Institut de Biologie Structurale et Microbiologie, CNRS, 31 Chemin Joseph Aiguier, 13009 Marseille, France
    J Bacteriol 189:8636-42. 2007
    The Bacillus subtilis BceAB ABC transporter involved in a defense mechanism against bacitracin is composed of a membrane-spanning domain and a nucleotide-binding domain...
  42. ncbi The bacA gene, which determines bacitracin susceptibility in Streptococcus pneumoniae and Staphylococcus aureus, is also required for virulence
    A F Chalker
    Anti Infective Research UP1345, SmithKline Beecham Pharmaceuticals, 1250 South Collegeville Road, PO Box 5089, Collegeville, PA 19426 0989, USA
    Microbiology 146:1547-53. 2000
    ..aureus bacA mutant showed slightly reduced virulence in a mouse model of infection and an eightfold increase in bacitracin susceptibility. However, a Strep...
  43. pmc Antibiotic resistance in Escherichia coll and Enterococcus spp. isolates from commercial broiler chickens receiving growth-promoting doses of bacitracin or virginiamycin
    Alexandre Thibodeau
    University of Montreal, Faculty of Veterinary Medicine, 3200 rue Sicotte, Saint Hyacinthe, Quebec J2S 2M2
    Can J Vet Res 72:129-36. 2008
    Antibacterial agents such as zinc bacitracin (ZB) and virginiamycin (VG) are used as growth promoting agents (GP) in broiler chicken production...
  44. pmc Inhibition of human immunodeficiency virus infection by agents that interfere with thiol-disulfide interchange upon virus-receptor interaction
    H J Ryser
    Department of Pathology, Boston University School of Medicine, MA 02118
    Proc Natl Acad Sci U S A 91:4559-63. 1994
    ..More recently it was found that the same membrane function can be inhibited by bacitracin, an inhibitor of protein disulfide-isomerase (PDI), and by monoclonal antibodies against PDI, suggesting that ..
  45. pmc Thiol/disulfide exchange is required for membrane fusion directed by the Newcastle disease virus fusion protein
    Surbhi Jain
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Virol 81:2328-39. 2007
    ..that inhibitors of cell surface thiol/disulfide isomerase activity--5'5-dithio-bis(2-nitrobenzoic acid) (DTNB), bacitracin, and anti-protein disulfide isomerase antibody--inhibited cell-cell fusion and virus entry but had no effect on ..
  46. pmc Genetic evidence for the actin homolog gene mreBH and the bacitracin resistance gene bcrC as targets of the alternative sigma factor SigI of Bacillus subtilis
    Chi Ling Tseng
    Institute of Biochemistry and Molecular Biology, School of Life Science, National Yang Ming University, Taipei 112, Taiwan
    J Bacteriol 190:1561-7. 2008
    ..search procedure, we found putative sigmaI promoters preceding the actin homolog gene mreBH and the bacitracin resistance gene bcrC of B. subtilis. Overexpression of the B...
  47. ncbi Metalloantibiotic Mn(II)-bacitracin complex mimicking manganese superoxide dismutase
    Theeraphon Piacham
    Department of Clinical Microbiology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand
    Biochem Biophys Res Commun 341:925-30. 2006
    ..g., free transition metal ions and metal-free bacitracin. The SOD activity of the complex was found to be in the order of Mn(II)>Cu(II)>Co(II)>Ni(II)...
  48. ncbi Comparison of soap and antibiotic solutions for irrigation of lower-limb open fracture wounds. A prospective, randomized study
    Jeffrey O Anglen
    Department of Orthopaedics, Indiana University, 541 Clinical Drive, Suite 600, Indianapolis, IN 46202 5111, USA
    J Bone Joint Surg Am 87:1415-22. 2005
    ..This study was performed to compare the efficacy of those two solutions in the treatment of open fractures in humans...
  49. ncbi Identification of multiple genes encoding membrane proteins with undecaprenyl pyrophosphate phosphatase (UppP) activity in Escherichia coli
    Meriem El Ghachi
    Laboratoire des Enveloppes Bactériennes et Antibiotiques, Unite Mixte de Recherche 8619 CNRS, Universite Paris Sud, 91405 Orsay, France
    J Biol Chem 280:18689-95. 2005
    ..Overexpression of either of these genes, or of a fourth identified one, yeiU, is shown to result in bacitracin resistance and increased levels of undecaprenyl pyrophosphate phosphatase activity, as previously observed for ..
  50. ncbi Optimization of HPLC method for stability testing of bacitracin
    V Pavli
    Department for Stability Testing, Krka Pharmaceuticals, Novo mesto, Slovenia
    J Pharm Biomed Anal 24:977-82. 2001
    A stability indicating HPLC assay for bacitracin has been developed and validated. The assay is based on a gradient elution, reversed phase column and UV diode array detection...
  51. ncbi The bacA gene of Escherichia coli encodes an undecaprenyl pyrophosphate phosphatase activity
    Meriem El Ghachi
    Laboratoire des Enveloppes Bactériennes et Antibiotiques, Institut de Biochimie et Biophysique Moleculaire et Cellulaire, UMR 8619 CNRS, Universite Paris Sud, Batiment 430, 91405 Orsay, France
    J Biol Chem 279:30106-13. 2004
    The bacA gene, the overexpression of which results in bacitracin resistance, was inactivated and shown to be non-essential for growth of Escherichia coli...
  52. doi Resistance to bacitracin in Streptococcus pyogenes from oropharyngeal colonization and noninvasive infections in Portugal was caused by two clones of distinct virulence genotypes
    Renato Pires
    Centro de Recursos Microbiológicos, Faculdade de Ciencias e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal
    FEMS Microbiol Lett 296:235-40. 2009
    During 2000-2007 in Lisbon, we identified 45 bacitracin-resistant Streptococcus pyogenes isolates among 1629 isolates: 24 from oropharyngeal healthy carriers (out of 1026), 21 from patients with noninvasive infections (out of 559) and ..
  53. pmc In vitro activities of ramoplanin, teicoplanin, vancomycin, linezolid, bacitracin, and four other antimicrobials against intestinal anaerobic bacteria
    D M Citron
    R M Alden Research Laboratory, Santa Monica, California 90404, USA
    Antimicrob Agents Chemother 47:2334-8. 2003
    ....
  54. ncbi The BceRS two-component regulatory system induces expression of the bacitracin transporter, BceAB, in Bacillus subtilis
    Reiko Ohki
    Department of Molecular Biology, School of Health Sciences, Kyorin University, 476 Miyashita, Hachiouji, Tokyo 192 0005, Japan
    Mol Microbiol 49:1135-44. 2003
    ..Disruption of these genes resulted in hypersensitivity to bacitracin, a peptide antibiotic that is non-ribosomally synthesized in some strains of Bacillus...
  55. ncbi BcrC from Bacillus subtilis acts as an undecaprenyl pyrophosphate phosphatase in bacitracin resistance
    Remi Bernard
    Laboratoire de Chimie Bacterienne, Institut de Biologie Structurale et Microbiologie, Batiment 430, 91405 Orsay Cedex, France
    J Biol Chem 280:28852-7. 2005
    ..called YwoA, in Escherichia coli or in Bacillus subtilis allows these bacteria to stand higher concentrations of bacitracin. It was suggested that BcrC(Bs) was a membrane-spanning domain of an ATP binding cassette (ABC) transporter ..
  56. ncbi Mechanism of bacitracin permeation enhancement through the skin and cellular membranes from an ethosomal carrier
    B Godin
    Department of Pharmaceutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, POB 12065, Jerusalem 91120, Israel
    J Control Release 94:365-79. 2004
    The main objective of the present work was to investigate the dermal and intracellular delivery of bacitracin, a model polypeptide antibiotic, from ethosomes...
  57. doi Bacitracin sensing in Bacillus subtilis
    Eva Rietkötter
    Department of General Microbiology, Georg August University, Gottingen, Germany
    Mol Microbiol 68:768-85. 2008
    ..The bacitracin stress response network of Bacillus subtilis consists of four signal-transducing systems, the two-component ..
  58. pmc Multilocus sequence typing analysis of Clostridium perfringens isolates from necrotic enteritis outbreaks in broiler chicken populations
    G Chalmers
    Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
    J Clin Microbiol 46:3957-64. 2008
    ..perfringens type A strains, was also found, but only in the presence of netB. Resistance to bacitracin was found in 34% of isolates from antimicrobial agent-free birds and in 100% of isolates from conventionally ..
  59. ncbi Engineered biosynthesis of the peptide antibiotic bacitracin in the surrogate host Bacillus subtilis
    K Eppelmann
    Department of Chemistry, Philipps University, D-35032 Marburg, Germany
    J Biol Chem 276:34824-31. 2001
    ..synthetases and subsequently used the same chromosomal location for integration of the entire 49-kilobase bacitracin biosynthetic gene cluster from Bacillus licheniformis by a stepwise homologous recombination method...
  60. ncbi Attempts to eradicate methicillin-resistant Staphylococcus aureus colonization with the use of trimethoprim-sulfamethoxazole, rifampin, and bacitracin
    J S Roccaforte
    Medical Services, Veterans Administration Medical Center, Omaha, NE 68105
    Am J Infect Control 16:141-6. 1988
    ..0 days) was oral trimethoprim-sulfamethoxazole, 160/800 mg twice daily, oral rifampin, 600 mg once daily, and bacitracin ointment three times a day. Eradication succeeded in 40 patients, 9 relapsed, and MRSA persisted in 7...
  61. ncbi The role of the bacitracin ABC transporter in bacitracin resistance and collateral detergent sensitivity
    Z Podlesek
    Department of Biology, University of Ljubljana, Slovenia
    FEMS Microbiol Lett 188:103-6. 2000
    The bacitracin resistance of Bacillus licheniformis, a producer of bacitracin, is mediated by the ABC transporter Bcr...
  62. ncbi A randomized controlled trial comparing mupirocin versus Polysporin Triple for the prevention of catheter-related infections in peritoneal dialysis patients (the MP3 study)
    Sarbjit V Jassal
    Department of Medicine, University of Toronto, and Division of Nephrology, University Health Network, Toronto, Ontario, Canada
    Perit Dial Int 28:67-72. 2008
    ....
  63. ncbi An alternative to antibiotic-based drugs in feed for enhancing performance of broilers grown on Eimeria spp.-infected litter
    V G Stanley
    Cooperative Agricultural Research Center, Prairie View A and M University, Prairie View, Texas 77446, USA
    Poult Sci 83:39-44. 2004
    Three trials were conducted to evaluate the effects of lasalocid, an anticoccidial feed additive (90.7 kg/ton); bacitracin, a growth-promoter (50 g/ton); and yeast culture residue (YCR) (1 kg/ton) on the performance of broiler chicks ..
  64. ncbi Postoperative topical antimicrobial use
    Vaneeta M Sheth
    Department of Dermatology and the Division of Dermatologic Surgery, The University of Texas Southwestern Medical Center, Dallas, TX, USA
    Dermatitis 19:181-9. 2008
    ..b>Bacitracin was also a common culprit, although at a lower rate (8%)...
  65. ncbi Comparison of dio-bacit, bacitracin-trimethoprim/ sulphamethoxazole and latex agglutination in the diagnosis of Group A beta-hemolytic streptococci
    Mustafa Altindis
    Department of Microbiology and Clinical Microbiology, Kocatepe University Faculty of Medicine, Afyon, Turkey
    Yonsei Med J 45:56-60. 2004
    ..media, Dio-Bacit, in a two section plate containing 5% sheep blood agar on one side and sheep blood agar with bacitracin (2 microg/ml) on the other was compared for its efficiency in identifying GAS with bacitracin and bacitracin + ..
  66. doi Adaptation to flavomycin in the ruminal bacterium, Prevotella bryantii
    J E Edwards
    Rowett Research Institute, Bucksburn, Aberdeen, UK
    J Appl Microbiol 104:1617-23. 2008
    ..This paper explores the adaptation mechanism of a common ruminal bacterium, Prevotella bryantii, to one of the banned compounds, flavomycin (flavophospholipol)...
  67. pmc Regulatory overlap and functional redundancy among Bacillus subtilis extracytoplasmic function sigma factors
    Thorsten Mascher
    Department of Microbiology, Wing Hall, Cornell University, Ithaca, NY 14853 8101, USA
    J Bacteriol 189:6919-27. 2007
    ..In several cases, these antibiotic-sensitive phenotypes are significantly enhanced in the triple mutant strain relative to strains lacking only one or two sigma factors...
  68. ncbi Risk factors for yeast superinfection in the treatment of suspected exit site infections: a case-control study
    L Oliveira
    Department of Medicine, University of Ottawa, Ottawa Hospital, Ottawa, Ontario, Canada
    J Vasc Access 9:35-8. 2008
    ..The purpose of our study was to determine if the use of polysporin double in the treatment of exit site infections was associated with the emergence of yeast positive exit site cultures...
  69. ncbi Isolation of bacillus subtilis MH-4 from soil and its potential of polypeptidic antibiotic production
    Bushra Jamil
    Department of Microbiology, Quaid i Azam, University, Islamabad, Pakistan
    Pak J Pharm Sci 20:26-31. 2007
    The genus Bacillus produces mainly polypeptide antibiotics such as bacitracin and polymyxin. Bacillus species were isolated from soil by soil sprinkle technique. And all were screened for the production of antibiotic...
  70. ncbi Use of antibiotic-containing ointment versus plain petrolatum during and after clean cutaneous surgery
    William D James
    J Am Acad Dermatol 55:915-6. 2006
  71. ncbi Povidone-iodine-induced burn: case report and review of the literature
    Donna O Lowe
    Department of Pharmacy Services, Toronto General Hospital, University Health Network, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Pharmacotherapy 26:1641-5. 2006
    ..Given the widespread use of povidone-iodine and the potential for development of infection after a burn, clinicians need to be aware of this possible povidone-iodine-associated adverse drug reaction, and of preventive measures...
  72. ncbi Effects of feed additives and mixed eimeria species infection on intestinal microbial ecology of broilers
    M E Hume
    Food and Feed Safety Research Unit, Southern Plains Agricultural Research Center, USDA, ARS, College Station, TX 77845, USA
    Poult Sci 85:2106-11. 2006
    ..microbial communities (MC) were examined in broilers fed diets supplemented with a combination of antibiotic (bacitracin methylene disalicylate) and ionophore (Coban 60), and diets containing 1 of 2 essential oil (EO) blends, Crina ..
  73. doi Microscopic and physiologic evidence for biofilm-associated wound colonization in vivo
    Stephen C Davis
    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Wound Repair Regen 16:23-9. 2008
    ..The structural and physiological results support the hypothesis that bacterial biofilms play a role in wound colonization and infection...
  74. ncbi The effects of Grobiotic-P on growth performance, nutrient digestibilities, and cecal microbial populations in young chicks
    P Biggs
    Department of Animal Sciences, University of Illinois, Urbana 61801, USA
    Poult Sci 87:1796-803. 2008
    ..diet containing no GB (negative control) and a diet containing an antibiotic growth promoter (positive control), bacitracin methylene disalicylate...
  75. ncbi Relationship of dietary antimicrobial drug administration with broiler performance, decreased population levels of Lactobacillus salivarius, and reduced bile salt deconjugation in the ileum of broiler chickens
    J Guban
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Canada
    Poult Sci 85:2186-94. 2006
    ..Birds raised in floor pens had lower BW and feed intakes than those raised in cages. The administration of bacitracin in the feed increased feed intake from d 12 to d 35, decreased the feed conversion ratio during the same period ..
  76. doi Skin testing after anaphylaxis to a topical Neosporin preparation
    Brian C Schroer
    Ann Allergy Asthma Immunol 101:444. 2008
  77. ncbi Effects of a dried Bacillus subtilis culture on egg quality
    L Li
    College of Animal Science and Technology, China Agricultural University, Beijing, PR China 214036 corrected
    Poult Sci 85:364-8. 2006
    ..The remaining groups received the control diet that contained either 20 mg of zinc bacitracin/kg and 4 mg of colistin sulfate/kg or 500, 1,000, or 1,500 mg of B. subtilis culture/ kg, respectively...
  78. ncbi Unmarked gene deletion mutagenesis of gtfB and gtfC in Streptococcus mutans using a targeted hit-and-run strategy with a thermosensitive plasmid
    D Atlagic
    Department of Oral Biology, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Oral Microbiol Immunol 21:132-5. 2006
    ..of about 99% and were analyzed for deletions of gtfB, gtfC and a part of mbrA by the lack of insoluble glucan synthesis, sensitivity to bacitracin, and polymerase chain reaction. Targeted gene deletions occurred at a frequency of 2.5%.
  79. ncbi Live attenuated vaccine-based control of necrotic enteritis of broiler chickens
    D R Thompson
    Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ont, Canada N1G 2W1
    Vet Microbiol 113:25-34. 2006
    ..The procedure used experimental infection for 5 days followed by bacitracin treatment for 9 days, and then re-challenge 2 days later with a virulent strain, CP4...
  80. ncbi Effect of growth promotant usage on enterococci species on a poultry farm
    Antoinette L Debnam
    Department of Avian Medicine, University of Georgia, Athens, GA 30605, USA
    Avian Dis 49:361-5. 2005
    ..and did not use any antimicrobials, while two other houses on the farm used flavomycin, virginiamycin, and bacitracin during different poultry grow-outs...
  81. ncbi Staphylococcal Drp35 is the functional counterpart of the eukaryotic PONs
    Kazuya Morikawa
    Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tennoh dai, Tsukuba 305 8575, Japan
    FEMS Microbiol Lett 249:185-90. 2005
    ..Drp35 is a lactonase that does not contribute directly to the resistance to the inducer antibiotics except for bacitracin. The detailed analysis on the expression of Drp35 revealed that in addition to a broad range of antibiotics, ..
  82. ncbi Contemporary antimicrobial activity of triple antibiotic ointment: a multiphased study of recent clinical isolates in the United States and Australia
    Ronald N Jones
    JMI Laboratories, North Liberty, IA 52317, USA
    Diagn Microbiol Infect Dis 54:63-71. 2006
    Triple antibiotic ointment (TAO) containing neomycin, polymyxin B, and bacitracin was launched in the 1950s in the United States (USA) as a prescription product and then was used over the counter (OTC) since the 1970s (USA) to prevent ..
  83. ncbi Bacterial isolates and antimicrobial susceptibilities in equine bacterial ulcerative keratitis (1993--2004)
    R L Keller
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, C247 Veterinary Teaching Hospital, Knoxville, Tennessee 37996 4544, USA
    Equine Vet J 37:207-11. 2005
    ..Emerging bacterial resistance to commonly used topical antibiotics has been demonstrated. Previous antibiotic use may alter the antimicrobial susceptibility of bacterial isolates...
  84. ncbi Allergic contact dermatitis from medical adhesive bandages in patients who report having a reaction to medical bandages
    Travis J Widman
    Oregon Health and Science University, Portland, OR, USA
    Dermatitis 19:32-7. 2008
    ..These reports do not adequately correspond to the frequency that patients report having an "allergy" to medical adhesive bandages...
  85. pmc Antimicrobial use and resistance in swine waste treatment systems
    Archana Jindal
    Department of Civil and Environmental Engineering, University of Illinois at Urbana Champaign, 3204 Newmark Civil Engineering Laboratory, MC250, 205 North Mathews Avenue, Urbana, IL 61801, USA
    Appl Environ Microbiol 72:7813-20. 2006
    ....
  86. ncbi A prospective, randomized pilot evaluation of topical triple antibiotic versus mupirocin for the prevention of uncomplicated soft tissue wound infection
    Robert Hood
    Department of Emergency Medicine, Cleveland Clinic Foundation, Metro Health Medical Center, Ohio 44195, USA
    Am J Emerg Med 22:1-3. 2004
    ..There were no serious adverse effects in either group. This pilot study found a similar rate of wound infection and adverse events between TAO and mupirocin ointments. Results should be confirmed in a larger equivalency trial...
  87. ncbi Influence of in-feed zinc bacitracin and tiamulin treatment on experimental avian intestinal spirochaetosis caused by Brachyspira intermedia
    D J Hampson
    Division of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, WA 6150, Australia
    Avian Pathol 31:285-91. 2002
    ..Birds received a diet containing 100 parts/10(6) zinc bacitracin (ZnB), and were monitored for 10 weeks. B...
  88. ncbi Susceptibility of Streptococcus mutans and Streptococcus sobrinus to cell wall inhibitors and development of a novel selective medium for S. sobrinus
    M Hirasawa
    Department of Microbiology, Nihon University School of Dentistry at Matsudo, Chiba, Japan
    Caries Res 36:155-60. 2002
    ..sobrinus and 125 microg/ml for S. mutans. Further addition of fosfomycin, bacitracin and sodium chloride to Mitis Salivarius agar (MS) supplemented with AZT resulted in growth inhibition of S...
  89. ncbi Dietary enzyme and zinc bacitracin reduce colonisation of layer hens by the intestinal spirochaete Brachyspira intermedia
    D J Hampson
    Division of Veterinary and Biomedical Sciences, Murdoch University, WA 6150, Perth, Australia
    Vet Microbiol 86:351-60. 2002
    ..birds were randomly divided into four groups of 10, with the diet for each group containing either 50 ppm zinc bacitracin (ZnB), 100 ppm ZnB, 256 ppm of dietary enzyme (Avizyme), 1302), or no additive...
  90. ncbi Evaluation of tiamulin and lincomycin for the treatment of broiler breeders experimentally infected with the intestinal spirochaete Brachyspira pilosicoli
    C P Stephens
    Toowoomba Veterinary Laboratory, Animal and Plant Health Service, Department of Primary Industries, Toowoomba, QLD 4350, Australia
    Avian Pathol 31:299-304. 2002
    ..At 29 weeks of age, all birds were transferred to a diet containing 50 parts/10(6) zinc bacitracin (ZnB) and were re-challenged with the same B. pilosicoli strain at 32 weeks of age, weekly for 5 weeks...
  91. ncbi Antimicrobial susceptibility of intestinal bacteria from Swiss poultry flocks before the ban of antimicrobial growth promoters
    A Frei
    Department of Food Science, Swiss Federal Institute of Technology,
    Syst Appl Microbiol 24:116-21. 2001
    ..faecium (27), staphylococci (n = 39) and lactobacilli (n = 14) showed a hundred percent resistance against bacitracin which was included in the feed of the mother animals, but not in the feed of the investigated animals. E...
  92. ncbi Prophylaxis of radiation-associated mucositis in conventionally treated patients with head and neck cancer: a double-blind, phase III, randomized, controlled trial evaluating the clinical efficacy of an antimicrobial lozenge using a validated mucositis sc
    S El-Sayed
    Ottawa Regional Cancer Centre, Ottawa, Ontario, Canada
    J Clin Oncol 20:3956-63. 2002
    ..randomized trial was to evaluate the clinical efficacy of an economically viable antimicrobial lozenge (bacitracin, clotrimazole, and gentamicin [BcoG]) in the alleviation of radiation-induced mucositis in patients with head ..
  93. ncbi [Comparison of checkerboard and time-kill methods for the analysis of two antibiotics combined]
    Wanda Grzybowska
    Zakład Antybiotyków i Mikrobiologii NIZP w Warszawie
    Med Dosw Mikrobiol 56:391-403. 2004
    ..Combinations of procaine penicillin, polymyxin B and bacitracin with neomycin and procaine penicillin with dihydrostreptomycin were examined...
  94. ncbi Susceptibility of skin and soft-tissue isolates of Staphylococcus aureus and Streptococcus pyogenes to topical antibiotics: indications of clonal spread of fusidic acid-resistant Staphylococcus aureus
    Jan Egil Afset
    Department of Microbiology, School of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Scand J Infect Dis 35:84-9. 2003
    ..Minimum inhibitory concentrations (MIC) of bacitracin, fusidic acid and mupirocin were tested using the E-test...
  95. ncbi [Topical antibiotics and clinical use]
    Salih Cesur
    Refik Saydam Hifzissihha Merkezi, Tüberküloz Referans Laboratuvan, Ankara
    Mikrobiyol Bul 36:353-61. 2002
    ..Topical antibiotics of choice include bacitracin, neomycin, polymyxin B, mupirocin, nitrofurazone and fusidic acid...
  96. pmc An antibiotic-inducible cell wall-associated protein that protects Bacillus subtilis from autolysis
    Letal I Salzberg
    Department of Microbiology, 370 Wing Hall, Cornell University, Ithaca, NY 14853, USA
    J Bacteriol 189:4671-80. 2007
    ..subtilis. These results support a model in which induction of YoeB in response to cell envelope stress decreases the activity of autolysins and thereby reduces the rate of antibiotic-dependent cell death...
  97. ncbi Beneficial effect of beta-mannanase feed enzyme on performance of chicks challenged with Eimerla sp. and Clostridium perfringens
    M E Jackson
    ChemGen Corp, Gaithersburg, MD 20877, USA
    Avian Dis 47:759-63. 2003
    ..The disease challenge model was therefore judged as highly effective. Additions of a commonly used antibiotic, bacitracin methylene disalicilate (BMD), and coccidiostat, salinomycin, were highly effective in partially counteracting ..
  98. ncbi Role of bile in intestinal barrier function and its inhibitory effect on bacterial translocation in obstructive jaundice in rats
    Yorihiko Ogata
    Department of Digestive Surgery, Graduate School of Medicine, University of Tokushima, Tokushima, Japan
    J Surg Res 115:18-23. 2003
    ..The aim of this study was to investigate the role of bile and bile acids in intestinal barrier function against bacterial translocation...
  99. ncbi Use of elemental iodine for shunt infection prophylaxis
    SooHo Choi
    Division of Neurosurgery, Childrens Hospital of Los Angeles, CA 90027, USA
    Neurosurgery 52:908-12; discussion 912-3. 2003
    ....
  100. ncbi Chronic foot ulcer. Identifying patient's current topical therapy aids in diagnosis
    Norman Levine
    University of Arizona Health Sciences Center, Tucson, USA
    Geriatrics 58:19. 2003
  101. ncbi Comparison of the effects of commonly used wound agents on epithelialization and neovascularization
    D Kjolseth
    Division of Plastic and Reconstructive Surgery, University of Louisville, KY 40292
    J Am Coll Surg 179:305-12. 1994
    ..In this study, we examined the effect of six commonly used topical wound agents (bacitracin, sodium hypochlorite, silver nitrate, silver sulfadiazine, mafenide acetate, and povidone-iodine) on ..

Research Grants29

  1. A Bacitracin derivative for systemic use
    Ake Elhammer; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  2. Structural studies of target recognition by large natural product antibiotics
    Patrick J Loll; Fiscal Year: 2010
    ..The specific molecules under study include ramoplanin, enduracidin, and bacitracin. The third class of antibiotics comprises cyclic decapeptides that permeabilize bacterial membranes...
  3. PDl: Function in thrombus formation and antithrombotic action of inhibitors in m
    Bruce Furie; Fiscal Year: 2012
    ..A time-dependent increase in PDl antigen was observed in the thrombus following injury. Infusion of bacitracin or a blocking monoclonal antibody to PDl into the circulation completely inhibited platelet thrombus formation ..
  4. REGULATION OF LEUKOCYTE L-SELECTIN SHEDDING VIA PDI
    Snezna Rogelj; Fiscal Year: 2004
    ..Adaptation of bacterially-derived, biofilm-degrading enzymes offers a novel option to biofitm control. Bacitracin, a peptide antibiotic derived from the biofilm-forming Bacillus licheniformis, inhibits the cell wall formation ..
  5. METABOLISM OF ERYTHROCYTE STROMA
    Stanley Schrier; Fiscal Year: 1980
    ..of transglutaminases in RBC endocytosis using the transglutaminase inhibitors histamine, dansylcadaverine, and bacitracin; the protein composition of the endocytic vacuoles produced in intact RBC...
  6. MECHANISM OF ACTION FOR BACITRACIN, POLYMYXIN AND EM 49
    Daniel Storm; Fiscal Year: 1980
    ..b>Bacitracin A inhibits the biosynthesis of peptidoglycan by forming a strong complex with the C55 isoprenyl pyrophosphate ..
  7. Structural studies of target recognition by large natural product antibiotics
    PATRICK LOLL; Fiscal Year: 2009
    ..The specific molecules under study include ramoplanin, enduracidin, and bacitracin. The third class of antibiotics comprises cyclic decapeptides that permeabilize bacterial membranes...
  8. Structural studies of target recognition by large natural product antibiotics
    PATRICK LOLL; Fiscal Year: 2007
    ..The specific molecules under study include ramoplanin, enduracidin, and bacitracin. The third class of antibiotics comprises cyclic decapeptides that permeabilize bacterial membranes...
  9. Structural studies of target recognition by large natural product antibiotics
    PATRICK LOLL; Fiscal Year: 2009
    ..The specific molecules under study include ramoplanin, enduracidin, and bacitracin. The third class of antibiotics comprises cyclic decapeptides that permeabilize bacterial membranes...
  10. FUNCTION OF ENKEPHALINS: RELATION TO PROSTAGLANDINS
    SEYMOUR EHRENPREIS; Fiscal Year: 1980
    ..Highest enzyme activity was found in the 20,000xg pellet. D-phenylalanine (DPA), bacitracin and puromycin were found to inhibit enkephalinases; inhibitory potency parallels analgesic activity in mice...
  11. Conformal Sealant for Burn Wound Repair
    Weiliam Chen; Fiscal Year: 2010
    ..In general, they may be covered with an occlusive dressing or a topical antimicrobial (e.g., Silvadene or bacitracin) cream and an absorptive dressing;evidently, these are all applied on an ad hoc basis and none of them promotes ..
  12. CATALYTIC ANTIBIOTICS
    John Griffin; Fiscal Year: 2002
    Vancomycin and bacitracin are peptide-derived natural products which exert antibacterial activity via inhibition of peptidoglycan biosynthesis...
  13. CATALYTIC ANTIBIOTICS
    John Griffin; Fiscal Year: 2001
    Vancomycin and bacitracin are peptide-derived natural products which exert antibacterial activity via inhibition of peptidoglycan biosynthesis...
  14. CATALYTIC ANTIBIOTICS
    John Griffin; Fiscal Year: 1999
    Vancomycin and bacitracin are peptide-derived natural products which exert antibacterial activity via inhibition of peptidoglycan biosynthesis...
  15. CATALYTIC ANTIBIOTICS
    John Griffin; Fiscal Year: 2000
    Vancomycin and bacitracin are peptide-derived natural products which exert antibacterial activity via inhibition of peptidoglycan biosynthesis...
  16. DRUGS DIRECTED AGAINST ISOPRENOID BIOSYNTHESIS
    Dean Crick; Fiscal Year: 1999
    ..The observation that M. tuberculosis is susceptible to the topical antibiotic bacitracin, which inhibits isoprenoid biosynthesis demonstrates that the synthesis of the isoprenoid compounds is required ..
  17. PROTEIN-LIPID INTERACTION
    Robert Gennis; Fiscal Year: 1980
    ..It is likely that the E. coli outer membrane is an active participant in this phenomenon. Bacitracin is a peptide antibiotic whose structure is known and which forms a complex with polyisoprenyl pyrophosphates...
  18. Understanding ceftazidime resistance in SHV B-Lactamases
    ROBERT BONOMO; Fiscal Year: 2008
    ..abstract_text> ..
  19. Challenges in beta-Lactamase Mediated Resistance
    Robert A Bonomo; Fiscal Year: 2010
    ..We will engineer mutations in these beta-lactamases to understand their catalytic properties, study the interactions of new inhibitors with these enzymes, and determine their structures by X-ray crystallography. ..
  20. Conference--Dermatologic Disease in Skin of Color
    Susan Taylor; Fiscal Year: 2002
    ..They believe that these presentations and discussions will lead to a greater interest in the specific problem related to access to care for dermatologic disease among persons of color. ..
  21. Multidrug resistant Acinetobacter baumannii,
    Robert A Bonomo; Fiscal Year: 2010
    ..baumannii, form a basis for the evaluation of novel beta-lactams, and show how enzyme drug targets influence substrate affinity and catalysis. ..
  22. Understanding ceftazidime resistance in SHV B-Lactamases
    ROBERT BONOMO; Fiscal Year: 2006
    ..abstract_text> ..
  23. Multidrug resistant Acinetobacter baumannii,
    ROBERT BONOMO; Fiscal Year: 2007
    ..baumannii, form a basis for the evaluation of novel beta-lactams, and show how enzyme drug targets influence substrate affinity and catalysis. ..
  24. Multidrug resistant Acinetobacter baumannii,
    ROBERT BONOMO; Fiscal Year: 2009
    ..baumannii, form a basis for the evaluation of novel beta-lactams, and show how enzyme drug targets influence substrate affinity and catalysis. ..
  25. Understanding ceftazidime resistance in SHV B-Lactamases
    ROBERT BONOMO; Fiscal Year: 2009
    ..abstract_text> ..
  26. Multidrug resistant Acinetobacter baumannii,
    ROBERT BONOMO; Fiscal Year: 2008
    ..baumannii, form a basis for the evaluation of novel beta-lactams, and show how enzyme drug targets influence substrate affinity and catalysis. ..
  27. Understanding ceftazidime resistance in SHV B-Lactamases
    ROBERT BONOMO; Fiscal Year: 2007
    ..abstract_text> ..