pyrenes

Summary

Summary: A group of condensed ring hydrocarbons.

Top Publications

  1. ncbi Rapid quantification of polycyclic aromatic hydrocarbons in hydroxypropyl-beta-cyclodextrin (HPCD) soil extracts by synchronous fluorescence spectroscopy (SFS)
    Guoxiong Hua
    School of Biology and Psychology, Institute for Research on Environment and Sustainability, Newcastle University, Newcastle upon Tyne, UK
    Environ Pollut 148:176-81. 2007
  2. ncbi Seasonal variations in spontaneous levels of DNA damage; implication in the risk assessment of environmental chemicals
    L Verschaeve
    VITO, Environmental Toxicology, Boeretang 200, B 2400 Mol, Belgium
    J Appl Toxicol 27:612-20. 2007
  3. doi Aldo-keto reductase 1C2 is essential for 1-nitropyrene's but not for benzo[a]pyrene's induction of p53 phosphorylation and apoptosis
    Jyan Gwo J Su
    Department of Biochemical Science and Technology, College of Life Sciences, National Chiayi University, Chiayi 600, Taiwan
    Toxicology 244:257-70. 2008
  4. doi Nitrogen gas purging for the deoxygenation of polyaromatic hydrocarbon solutions in cyclohexane for routine fluorescence analysis
    Todd Pagano
    Department of Science and Mathematics, Laboratory Science Technology Program, Rochester Institute of Technology, National Technical Institute for the Deaf, 52 Lomb Memorial Drive, Rochester, New York 14623, USA
    Appl Spectrosc 62:333-6. 2008
  5. ncbi Biotransformation and bioconcentration of pyrene in Daphnia magna
    Jarkko Akkanen
    Department of Biology, Laboratory of Aquatic Ecology and Ecotoxicology, University of Joensuu, P O Box 111, FIN 80101, Joensuu, Finland
    Aquat Toxicol 64:53-61. 2003
  6. doi Low levels of the air pollutant 1-nitropyrene induce DNA damage, increased levels of reactive oxygen species and endoplasmic reticulum stress in human endothelial cells
    Helen Andersson
    Uppsala University, Department of Pharmaceutical Biosciences, BMC, Uppsala, Sweden
    Toxicology 262:57-64. 2009
  7. pmc 2H-NMR study and molecular dynamics simulation of the location, alignment, and mobility of pyrene in POPC bilayers
    Barbara Hoff
    IMVM, Bioprocess Engineering, University of Karlsruhe, 76131 Karlsruhe, Germany
    Biophys J 88:1818-27. 2005
  8. doi Urinary 1-hydroxypyrene (1-HP) in environmental and occupational studies--a review
    Ase M Hansen
    National Research Centre for the Working Environment NRCWE, 105 Lersø Parkallé, DK 2100 Copenhagen, Denmark
    Int J Hyg Environ Health 211:471-503. 2008
  9. pmc Monitoring of fatty aldehyde dehydrogenase by formation of pyrenedecanoic acid from pyrenedecanal
    Markus A Keller
    Division of Biological Chemistry, Biocenter, Innsbruck Medical University, A 6020 Innsbruck, Austria
    J Lipid Res 51:1554-9. 2010
  10. ncbi Unambiguous detection of target DNAs by excimer-monomer switching molecular beacons
    Kazuhisa Fujimoto
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    J Org Chem 69:3271-5. 2004

Detail Information

Publications215 found, 100 shown here

  1. ncbi Rapid quantification of polycyclic aromatic hydrocarbons in hydroxypropyl-beta-cyclodextrin (HPCD) soil extracts by synchronous fluorescence spectroscopy (SFS)
    Guoxiong Hua
    School of Biology and Psychology, Institute for Research on Environment and Sustainability, Newcastle University, Newcastle upon Tyne, UK
    Environ Pollut 148:176-81. 2007
    ..Hence, SFS is a potential means to simplify the present non-exhaustive hydroxypropyl-beta-cyclodextrin (HPCD)-based extraction technique for the evaluation of PAH bioavailability in soil...
  2. ncbi Seasonal variations in spontaneous levels of DNA damage; implication in the risk assessment of environmental chemicals
    L Verschaeve
    VITO, Environmental Toxicology, Boeretang 200, B 2400 Mol, Belgium
    J Appl Toxicol 27:612-20. 2007
    ..The investigation confirms that the blood sampling period is crucial in the planning and interpretation of biomonitoring studies...
  3. doi Aldo-keto reductase 1C2 is essential for 1-nitropyrene's but not for benzo[a]pyrene's induction of p53 phosphorylation and apoptosis
    Jyan Gwo J Su
    Department of Biochemical Science and Technology, College of Life Sciences, National Chiayi University, Chiayi 600, Taiwan
    Toxicology 244:257-70. 2008
    ..The metabolic and signaling pathways for the toxic effects of both 1-NP and B[a]P are similar except that AKR1C2 plays differential role between them. The results provide valuable information for further investigations on AKRs...
  4. doi Nitrogen gas purging for the deoxygenation of polyaromatic hydrocarbon solutions in cyclohexane for routine fluorescence analysis
    Todd Pagano
    Department of Science and Mathematics, Laboratory Science Technology Program, Rochester Institute of Technology, National Technical Institute for the Deaf, 52 Lomb Memorial Drive, Rochester, New York 14623, USA
    Appl Spectrosc 62:333-6. 2008
    ..61 +/- 0.02, 4.17 +/- 0.02, 7.63 +/- 0.07, and 21.81 +/- 0.35, respectively...
  5. ncbi Biotransformation and bioconcentration of pyrene in Daphnia magna
    Jarkko Akkanen
    Department of Biology, Laboratory of Aquatic Ecology and Ecotoxicology, University of Joensuu, P O Box 111, FIN 80101, Joensuu, Finland
    Aquat Toxicol 64:53-61. 2003
    ..The data demonstrate capability and importance of CYP monooxygenases in biotransformation of polycyclic aromatic hydrocarbons in D. magna...
  6. doi Low levels of the air pollutant 1-nitropyrene induce DNA damage, increased levels of reactive oxygen species and endoplasmic reticulum stress in human endothelial cells
    Helen Andersson
    Uppsala University, Department of Pharmaceutical Biosciences, BMC, Uppsala, Sweden
    Toxicology 262:57-64. 2009
    ..Our findings suggest that the human blood vessel endothelium is a sensitive target tissue for the major nitro-PAH constituent in diesel exhaust...
  7. pmc 2H-NMR study and molecular dynamics simulation of the location, alignment, and mobility of pyrene in POPC bilayers
    Barbara Hoff
    IMVM, Bioprocess Engineering, University of Karlsruhe, 76131 Karlsruhe, Germany
    Biophys J 88:1818-27. 2005
    ..The good agreement can be explained by the fact that the different kind of motions of a pyrene molecule are already averaged within a few nanoseconds, which is the timescale covered by the MD simulation...
  8. doi Urinary 1-hydroxypyrene (1-HP) in environmental and occupational studies--a review
    Ase M Hansen
    National Research Centre for the Working Environment NRCWE, 105 Lersø Parkallé, DK 2100 Copenhagen, Denmark
    Int J Hyg Environ Health 211:471-503. 2008
    ..The highest contribution originates from environmental tobacco smoke, but also different country, cooking culture, and behavior influences urinary of 1-HP...
  9. pmc Monitoring of fatty aldehyde dehydrogenase by formation of pyrenedecanoic acid from pyrenedecanal
    Markus A Keller
    Division of Biological Chemistry, Biocenter, Innsbruck Medical University, A 6020 Innsbruck, Austria
    J Lipid Res 51:1554-9. 2010
    ..Thus, monitoring of pyrenedecanoic acid formation from pyrenedecanal by HPLC with fluorescence detection provides a robust and sensitive method for determination of fatty aldehyde dehydrogenase activity...
  10. ncbi Unambiguous detection of target DNAs by excimer-monomer switching molecular beacons
    Kazuhisa Fujimoto
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    J Org Chem 69:3271-5. 2004
    ..Advantages of the excimer-monomer switching molecular beacons were discussed in comparison with conventional ones...
  11. doi Inhibition of free DNA degradation by the deformation of DNA exposed to trace polycyclic aromatic hydrocarbon contaminants
    Fuxing Kang
    Institute of Organic Contaminant Control and Soil Remediation, College of Resource and Environmental Science, Nanjing Agricultural University, Nanjing 210095, PR China
    Environ Sci Technol 44:8891-6. 2010
    ....
  12. ncbi Benchmark guideline for urinary 1-hydroxypyrene as biomarker of occupational exposure to polycyclic aromatic hydrocarbons
    F J Jongeneelen
    IndusTox Consult, PO Box 31070, NL 6503 CB, Nijmegen, The Netherlands
    Ann Occup Hyg 45:3-13. 2001
    ..3 micromol mol(-1) creatinine and 4.9 micromol mol(-1) creatinine, respectively, in these two industries. These latter values present the third level of the benchmark guideline...
  13. ncbi Short- and long-term sorption/desorption of polycyclic aromatic hydrocarbons onto artificial solids: effects of particle and pore sizes and organic matters
    Hongwen Sun
    Department of Environmental Engineering, Graduate School of Engineering, Osaka University, Yamadaoka 2 1, Suita, Osaka 565 0871, Japan
    Water Res 37:2960-8. 2003
    ..Irreversibility of desorption is considered to be a more influencing factor than percentage of desorption for describing the extent of sequestration...
  14. doi Excretion profiles and half-lives of ten urinary polycyclic aromatic hydrocarbon metabolites after dietary exposure
    Zheng Li
    Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, GA 30341, USA
    Chem Res Toxicol 25:1452-61. 2012
    ..It is essential to consider the relatively short half-life, the timing of samples relative to exposures, and the effect of diet when conducting PAH exposure biomonitoring studies...
  15. ncbi Urinary 1-hydroxypyrene concentrations in Chinese coke oven workers relative to job category, respirator usage, and cigarette smoking
    Bo Chen
    School of Public Health, Fudan University, Shanghai, P R China
    Am J Ind Med 50:657-63. 2007
    ..We investigated whether urinary 1-OHP concentrations in Chinese coke oven workers (COWs) are modulated by job category, respirator usage, and cigarette smoking...
  16. ncbi Pyrene biotransformation and kinetics in the hepatopancreas of the isopod Porcellio scaber
    G J Stroomberg
    Institute for Environmental Studies, Vrije Universiteit, De Boelelaan 1087, 1081 HV, Amsterdam, Netherlands
    Arch Environ Contam Toxicol 47:324-31. 2004
    ....
  17. doi Uptake of polycyclic aromatic hydrocarbons by Trifolium pretense L. from water in the presence of a nonionic surfactant
    Yanzheng Gao
    College of Resource and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China
    Chemosphere 72:636-43. 2008
    ..Results from this study show promises for the potential efficacy of enhanced phytoremediation in PAH contaminated sites using surfactant amendment...
  18. ncbi Sensitive biomarker of polycyclic aromatic hydrocarbons (PAHs): urinary 1-hydroxyprene glucuronide in relation to smoking and low ambient levels of exposure
    Y Hu
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    Biomarkers 11:306-18. 2006
    ..Furthermore, multiple regression analyses of 1-OHP-G on PAHs exposure indicated that cigarette smoke was a major confounding factor and should be considered and adjusted for while using 1-OHP to estimate PAHs exposure...
  19. doi Determinants of urinary 1-hydroxypyrene glucuronide in South Korean children
    Kyoung Ho Lee
    Biomedical Research Group, Hanyang Brain Korea 21, Hanyang University, Seoul, Republic of Korea
    Int Arch Occup Environ Health 82:961-8. 2009
    ..This study was conducted to investigate the dominant sources of the urinary pyrene metabolite, 1-hydroxypyrene glucuronide (1-OHPG), in South Korean children...
  20. pmc Synthesis of oligonucleotides containing 2'-deoxyguanosine adducts of nitropyrenes
    Laureen C Colis
    Department of Chemistry, University of Connecticut, Storrs, Connecticut 06269, USA
    Nucleosides Nucleotides Nucleic Acids 28:67-77. 2009
    ..A total synthetic approach, by contrast, involves several synthetic steps, including Buchwald-Hartwig Pd-catalyzed coupling, but can be used for incorporating both the major and minor adducts in DNA in high yield...
  21. doi Occupational exposure to polycyclic aromatic hydrocarbons and DNA damage by industry: a nationwide study in Germany
    Boleslaw Marczynski
    BGFA Research Institute of Occupational Medicine, German Social Accident Insurance, Ruhr University Bochum, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    Arch Toxicol 83:947-57. 2009
    ..The type of industry contributed to genotoxic DNA damage and DNA damage was not unequivocally associated to PAH on the individual level most likely due to potential contributions of co-exposures...
  22. pmc An early transition state for folding of the P4-P6 RNA domain
    S K Silverman
    Department of Chemistry and Biochemistry, University of Colorado at Boulder, 80309 0215, USA
    RNA 7:161-6. 2001
    ..Our kinetic data are some of the first to provide quantitative values for an activation barrier and location of a transition state for tertiary folding of an RNA domain...
  23. ncbi Multiple folding pathways for the P4-P6 RNA domain
    S K Silverman
    Department of Chemistry and Biochemistry and Howard Hughes Medical Institute, University of Colorado at Boulder, Boulder, Colorado 80309, USA
    Biochemistry 39:12465-75. 2000
    ..The fast kinetic phase reflects folding that is facilitated by these interactions, whereas the slow kinetics are observed when these interactions are disrupted at lower ionic strength and higher temperature...
  24. pmc Traffic-related air pollution and DNA damage: a longitudinal study in Taiwanese traffic conductors
    Han Bin Huang
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    PLoS ONE 7:e37412. 2012
    ....
  25. ncbi Urinary 1-hydroxypyrene-glucuronide as a biomarker of exposure to various vehicle exhausts among highway toll-station workers in Taipei, Taiwan
    Ching Huang Lai
    Department of Public Health, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Arch Environ Health 59:61-9. 2004
    ..The authors determined that exposure to various traffic exhausts increased the urinary concentration of 1-OHP-gluc in a dose-response pattern, which suggests that this chemical may be a useful biomarker for exposure to vehicle exhausts...
  26. ncbi Simultaneous determination of urinary hydroxylated metabolites of naphthalene, fluorene, phenanthrene, fluoranthene and pyrene as multiple biomarkers of exposure to polycyclic aromatic hydrocarbons
    Thaneeya Chetiyanukornkul
    Environmental Science Program, Faculty of Science, Chiang Mai University, Chiang Mai, 50200, Thailand
    Anal Bioanal Chem 386:712-8. 2006
    ..The results showed higher urinary concentrations of OHPAHs in rural villagers, consistent with higher respiratory exposure to PAHs...
  27. ncbi 1-Hydroxypyrene concentrations in first morning voids and 24-h composite urine: intra- and inter-individual comparisons
    In Kyu Han
    School of Public Health, Department of Environmental and Occupational Health, University of Medicine and Dentistry of New Jersey, 683 Hoes Lane West, Piscataway, New Jersey 08854, USA
    J Expo Sci Environ Epidemiol 18:477-85. 2008
    ..Creatinine adjustments did not significantly improve overall correlations between first morning void and 24-h measurements, but increased total variances for 24-h urines explained by first morning urines in coke workers...
  28. ncbi Urinary 1-hydroxypyrene as an indicator for assessing the exposures of booth attendants of a highway toll station to polycyclic aromatic hydrocarbons
    Perng Jy Tsai
    Department of Environmental and Occupational Health, Medical College, National Cheng Kung University, 138 Sheng Li Road, Tainan 704, Taiwan
    Environ Sci Technol 38:56-61. 2004
    ....
  29. ncbi Influence of genetic polymorphisms of CYP1A1 and GSTM1 on the urinary levels of 1-hydroxypyrene
    P Apostoli
    Chair of Industrial Hygiene, Department of Experimental and Applied Medicine, University of Brescia, P le Spedali Civili, 1, Brescia 25123, Italy
    Toxicol Lett 144:27-34. 2003
    ..No influence of the genetic polymorphism of CYP1A1 and GSTM1 on the urinary levels of 1-OH-P was observed in this study...
  30. pmc Association between urinary 1-hydroxypyrene and genotoxic effects in coke oven workers
    E Siwinska
    Institute of Occupational Medicine and Environmental Health, 13 Koscielna St, 41 200 Sosnowiec, Poland
    Occup Environ Med 61:e10. 2004
    ....
  31. ncbi Urinary hydroxy-metabolites of naphthalene, phenanthrene and pyrene as markers of exposure to diesel exhaust
    Leea Kuusimaki
    Finnish Institute of Occupational Health, Topeliuksenkatu 41aA, 00250 Helsinki, Finland
    Int Arch Occup Environ Health 77:23-30. 2004
    ....
  32. pmc Pyrene is highly emissive when attached to the RNA duplex but not to the DNA duplex: the structural basis of this difference
    Mitsunobu Nakamura
    Department of Materials Science and Chemistry, University of Hyogo, 2167 Shosha, Himeji, Hyogo 671 2201, Japan
    Nucleic Acids Res 33:5887-95. 2005
    ..Molecular dynamics simulations support these differences in the local structural elements around the pyrene between the pyrene-RNA/RNA and the pyrene-DNA/DNA duplexes...
  33. pmc Pyrene excimer signaling molecular beacons for probing nucleic acids
    Patrick Conlon
    Center for Research at Bio nano Interface, Department of Chemistry and Shands Cancer Center, University of Florida Genetics Institute, University of Florida, Gainesville, Florida 32611 7200, USA
    J Am Chem Soc 130:336-42. 2008
    ..The long fluorescence lifetime ( approximately 40 ns), large Stokes shift (130 nm), and tunable intensity of the excimer make this multiple-pyrene moiety a useful alternative to traditional fluorophore labeling in nucleic acid probes...
  34. pmc Exposure to traffic exhausts and oxidative DNA damage
    C H Lai
    Department of Public Health, National Defence Medical Center, Taipei, Taiwan 114, ROC
    Occup Environ Med 62:216-22. 2005
    ..To assess the relations between exposure to traffic exhausts and indicators of oxidative DNA damage among highway toll station workers...
  35. pmc Optimization of excimer-forming two-probe nucleic acid hybridization method with pyrene as a fluorophore
    M Masuko
    Tsukuba Research Laboratory, Hamamatsu Photonics K K, Tokodai, Tsukuba 300 2635, Japan
    Nucleic Acids Res 26:5409-16. 1998
    ..two-probe nucleic acid hybridization (ETPH) method, is based on specific excimer formation between two pyrenes attached at the neighboring terminals of two sequential probe oligonucleotides complementary to a single target...
  36. pmc Higher urine 1-hydroxy pyrene glucuronide (1-OHPG) is associated with tobacco smoke exposure and drinking maté in healthy subjects from Rio Grande do Sul, Brazil
    Renato B Fagundes
    Universidade Federal de Santa Maria, Departamento de Clinica Medica, Centro de Ciencias da Saude, Santa Maria, RS, Brazil
    BMC Cancer 6:139. 2006
    ..The aims of the current study were to investigate the degree and sources of PAH exposure of the inhabitants of this region of southern Brazil...
  37. doi Unique sandwich stacking of pyrene-adenine-pyrene for selective and ratiometric fluorescent sensing of ATP at physiological pH
    Zhaochao Xu
    Department of Chemistry and Nano Science and Department of Bioinspired Science, Ewha Womans University, Seoul, 120 750, Korea
    J Am Chem Soc 131:15528-33. 2009
    ..Sensor 1 is also applied to monitor the hydrolysis of ATP and ADP by apyrase. The results indicate that 1 is a useful fluorescent sensor for investigations of ATP-relevant biological processes...
  38. doi Supramolecular chemical sensors based on pyrene monomer-excimer dual luminescence
    Sekar Karuppannan
    ICMUB, CNRS, UMR, Universite de Bourgogne, Dijon, France
    Chem Asian J 6:964-84. 2011
    ..This induces a conformational change or the exchange of a component of the system, which is the cause of the luminescence switch effect...
  39. ncbi Calcium-dependent protein-protein interactions induce changes in proximity relationships of Cys48 and Cys64 in chicken skeletal troponin I
    Ying Ming Liou
    Department of Life Science, Institute of Biochemistry, National Chung Hsing University, Taichung, Taiwan
    Eur J Biochem 270:3092-100. 2003
    ..Thus a conformational change in the N-terminal region of TnI may be necessary for full activation of muscle contraction...
  40. ncbi Urinary 1-hydroxypyrene and polycyclic aromatic hydrocarbon exposure among asphalt paving workers
    M D McClean
    Harvard School of Public Health, Boston, MA 02115, USA
    Ann Occup Hyg 48:565-78. 2004
    ....
  41. ncbi Degradation of pyrene by Mycobacterium flavescens
    D Dean-Ross
    Department of Biology, Indiana University Purdue University at Fort Wayne 46805 1499, USA
    Appl Microbiol Biotechnol 46:307-12. 1996
    ..The product of initial ring oxidation, 4,5-dihydroxy-4,5-dihydropyrene was identified, as well as ring-fission products including 4-phenanthroic acid, phthalic acid, and 4,5-phenanthrenedioic acid...
  42. ncbi Pyrene-labeled base-discriminating fluorescent DNA probes for homogeneous SNP typing
    Akimitsu Okamoto
    Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University and SORST, Japan Science and Technology Corporation, Kyoto 615 8510, Japan
    J Am Chem Soc 126:4820-7. 2004
    ..Py)U- and (Py)C-containing oligodeoxynucleotides acted as effective reporter probes for homogeneous SNP typing of DNA samples containing c-Ha-ras and BRCA2 SNP sites...
  43. ncbi Pyrene-labeled oligodeoxynucleotide probe for detecting base insertion by excimer fluorescence emission
    Akimitsu Okamoto
    Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University and SORST, Japan Science and Technology Corporation, Kyoto 615 8510, Japan
    J Am Chem Soc 126:8364-5. 2004
    ..This method is useful for the determination of the presence/absence of insertion polymorphisms located at a specific site on the target DNA...
  44. ncbi Biological monitoring of exposure to mixtures
    Claude Viau
    Human Toxicology Research Group, Department of Environmental and Occupational Health, University of Montreal, QC, Canada
    Toxicol Lett 134:9-16. 2002
    ..Finally, there is clearly a need for a greater research effort on the toxicology of mixtures to make biological monitoring a useful tool in occupational health...
  45. ncbi Anionic fullerenes, calixarenes, coronenes, and pyrenes as activators of oligo/polyarginines in model membranes and live cells
    Florent Perret
    Department of Organic Chemistry, University of Geneva, Geneva, Switzerland, Institute for Chemical Research, Kyoto University and PRESTO, JST, Kyoto, Japan
    J Am Chem Soc 127:1114-5. 2005
    ..Applied to HeLa cells, pyrenebutyrate is shown to significantly increase the uptake of a fluorescently labeled octaarginine in a concentration-dependent manner...
  46. ncbi Pyrene excimer fluorescence of yeast alcohol dehydrogenase: a sensitive probe to investigate ligand binding and unfolding pathway of the enzyme
    Manas Kumar Santra
    School of Biosciences and Bioengineering, Indian Institute of Technology, Bombay, Powai, Mumbai, India
    Photochem Photobiol 82:480-6. 2006
    ..5 M GdnHCl. Interestingly, residual structures of YADH were detected even in the presence of 5 M GdnHCl using the excimer fluorescence of PM-YADH...
  47. doi 1-Hydroxypyrene as a biomarker of PAH exposure in the marine polychaete Nereis diversicolor
    Zhanna M Tairova
    Department of Science, Systems and Models, Roskilde University, Universitetsvej 1, DK 4000 Roskilde, Denmark
    Mar Environ Res 67:38-46. 2009
    ....
  48. ncbi Urinary 1-hydroxypyrene and 2-naphthol concentrations in male Koreans
    H Kim
    Department of Preventive Medicine, College of Medicine, Chungbuk National University, 48 San Kaeshin dong, Hungdok gu, Cheongju, Chungbuk 361 763, S Korea
    Int Arch Occup Environ Health 74:59-62. 2001
    ..We analyzed urinary 1-OHP and 2-naphthol concentrations in 292 male Koreans (129 university students and 163 shipyard workers) to define the distribution pattern in Koreans with no or low occupational exposure to PAHs...
  49. ncbi Biliary 1-hydroxypyrene as a biomarker of exposure to polycyclic aromatic hydrocarbons in fish
    Jana Blahova
    Department of Veterinary Public Health and Toxicology, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic
    Neuro Endocrinol Lett 29:663-8. 2008
    ..The aim of this study was the assessment of the Svitava and Svratka rivers contamination by polycyclic aromatic hydrocarbons (PAH) using 1-hydroxypyrene (1-OHP) concentrations in fish bile as a biomarker...
  50. pmc Intercalating nucleic acids containing insertions of 1-O-(1-pyrenylmethyl)glycerol: stabilisation of dsDNA and discrimination of DNA over RNA
    Ulf B Christensen
    Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, DK 5230 Odense M, Denmark
    Nucleic Acids Res 30:4918-25. 2002
    ..Fluorescence measurements show a stronger interaction of the pyrene moiety with DNA than with RNA, indicating intercalation as the stabilising factor in DNA/INA duplexes...
  51. pmc Elevated levels of urinary 8-hydroxy-2 -deoxyguanosine, lymphocytic micronuclei, and serum glutathione S-transferase in workers exposed to coke oven emissions
    Ai Lin Liu
    Department of Occupational and Environmental Health and Ministry of Education Key Lab for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Environ Health Perspect 114:673-7. 2006
    ..The consequences of the changes in these biomarkers, such as risk of cancer, warrant further investigations...
  52. ncbi Toxicological and biochemical responses of the earthworm Lumbricus rubellus to pyrene, a non-carcinogenic polycyclic aromatic hydrocarbon
    P J Brown
    Centre for Ecology and Hydrology, Monks Wood, Abbots Ripton, Huntingdon, Cambridgeshire PE28 2LS, UK
    Chemosphere 57:1675-81. 2004
    ....
  53. ncbi Bis-pyrene-labeled oligonucleotides: sequence specificity of excimer and monomer fluorescence changes upon hybridization with DNA
    Kazushige Yamana
    Department of Applied Chemistry, Himeji Institute of Technology, 2167 Shosha, Himeji, Hyogo 671 2201, Japan
    Bioconjug Chem 13:1266-73. 2002
    ..The excimer and monomer fluorescence changes were found to be sensitive to a mismatch base present in the target DNA. The bis-pyrene-modified ODNs thus provide a sequence-sepcific fluorescent probe of DNA...
  54. doi Modulation of pyrene fluorescence in DNA probes depends upon the nature of the conformationally restricted nucleotide
    Dmytro Honcharenko
    Department of Bioorganic Chemistry, Box 581, Biomedical Center, Uppsala University, SE 75123 Uppsala, Sweden
    J Org Chem 73:2829-42. 2008
    ..Our data corroborate that the pyrene moiety is intercalated in the X-modified mismatched ODN/RNA (G mismatch) heteroduplex as compared to that of the Y-modified ODN/RNA (G mismatch) heteroduplex, in which it is located outside the helix...
  55. pmc Integrity of duplex structures without hydrogen bonding: DNA with pyrene paired at abasic sites
    Serge Smirnov
    Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
    Nucleic Acids Res 30:5561-9. 2002
    ..The results support the idea that the stability and replication of a P.F pair is due to its ability to mimic Watson-Crick structure...
  56. ncbi A fluorescent probe-labeled Escherichia coli aspartate transcarbamoylase that monitors the allosteric conformational state
    Jay M West
    Department of Chemistry, Boston College, Merkert Chemistry Center, Chestnut Hill, Massachusetts 02467, USA
    J Biol Chem 279:945-51. 2004
    ....
  57. pmc Mechanism of template-independent nucleotide incorporation catalyzed by a template-dependent DNA polymerase
    Kevin A Fiala
    Department of Biochemistry, The Ohio State University, Columbus, OH 43210, USA
    J Mol Biol 365:590-602. 2007
    ..This unprecedented base-stacking pattern can be applied to subsequent blunt-end additions only if all incorporated dAMPs are extrahelical, leading to predominantly single non-templated dATP incorporation...
  58. doi Pyrene fluorescence analysis offers new insights into the conformation of the lipoprotein-binding domain of human apolipoprotein E
    Arti B Patel
    Department of Chemistry and Biochemistry, 1250 Bellflower Boulevard, California State University Long Beach, Long Beach, California 90840, USA
    Biochemistry 49:1766-75. 2010
    ..This study presents the possibility of employing pyrene fluorophores as powerful new alternatives to obtain conformational information of proteins at physiologically relevant concentrations...
  59. ncbi High exposure to polycyclic aromatic hydrocarbons may contribute to high risk of esophageal cancer in northeastern Iran
    Farin Kamangar
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 21218, USA
    Anticancer Res 25:425-8. 2005
    ..The northeastern region of Iran has some of the highest rates of esophageal squamous cell carcinoma (ESCC) in the world...
  60. ncbi [An improved high performance liquid chromatography method for determination of 1-hydroxypyrene in urine]
    Xiaohua Li
    National Institute of Occupational Medicine and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China
    Wei Sheng Yan Jiu 32:616-7. 2003
    ..This method is sensitive, efficient and reliable, and was successfully used for the determination of 1-hydroxypyrene in urine of workers exposed to polycyclic aromatic hydrocarbon...
  61. ncbi Urinary 1-hydroxypyrene in children living in city and rural residences in Denmark
    Ase Marie Hansen
    National Institute of Occupational Health, Copenhagen Ø, Denmark
    Sci Total Environ 347:98-105. 2005
    ..The present study aims to assess the biological uptake in children of polycyclic aromatic hydrocarbons measured as 1-hydroxypyrene in urine from children living in city and rural residences...
  62. ncbi Associations between XRCC1 and ERCC2 polymorphisms and DNA damage in peripheral blood lymphocyte among coke oven workers
    Shuguang Leng
    National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China
    Biomarkers 9:395-406. 2004
    ....
  63. ncbi Plant-accelerated dissipation of phenanthrene and pyrene from water in the presence of a nonionic-surfactant
    Yanzheng Gao
    College of Resource and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China
    Chemosphere 63:1560-7. 2006
    ..Results obtained from this study provided some insight with regard to the feasibility of phytoremediation for PAH contaminated water bodies with coexisted contaminants of surfactants...
  64. ncbi Elevated concentrations of 1-hydroxypyrene in schoolchildren during winter in Christchurch, New Zealand
    Jo Anne E Cavanagh
    Landcare Research, PO Box 40, Lincoln 7640, New Zealand
    Sci Total Environ 374:51-9. 2007
    ....
  65. ncbi Adsorption of polycyclic aromatic hydrocarbons by carbon nanomaterials
    Kun Yang
    Department of Plant, Soil and Insect Sciences, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Environ Sci Technol 40:1855-61. 2006
    ..In addition, high adsorption capacity of PAHs by carbon nanotubes may add to their high environmental risks once released to the environment, and result in potential alteration of PAHs fate and bioavailability in the environment...
  66. ncbi Application of the partition-limited model for plant uptake of organic chemicals from soil and water
    Yanzheng Gao
    Department of Environmental Sciences, Zhejiang University, Hangzhou 310028, China
    Sci Total Environ 336:171-82. 2005
    ..05, n = 10). This investigation substantiated the concept of the partition-limited model and its utility for vegetation-uptake assessment...
  67. ncbi Stable and selective formation of hoogsteen-type triplexes and duplexes using twisted intercalating nucleic acids (TINA) prepared via postsynthetic Sonogashira solid-phase coupling reactions
    Vyacheslav V Filichev
    Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
    J Am Chem Soc 127:14849-58. 2005
    ..0 degrees C at pH 7.2, while the T(m) of unmodified dsDNA was 47.0 degrees C. Experiments with mismatched oligonucleotides, luminescent properties, and potential applications of TINA technology is discussed...
  68. ncbi Plant uptake, accumulation and translocation of phenanthrene and pyrene in soils
    Yanzheng Gao
    Department of Environmental Sciences, Zhejiang University, Hangzhou 310028, China
    Chemosphere 55:1169-78. 2004
    ..24% for pyrene in planted versus unplanted control soils, whereas plant-promoted biodegradation was the predominant contribution of remediation enhancement of soil phenanthrene and pyrene in the presence of vegetation...
  69. pmc Diesel exhaust exposure among adolescents in Harlem: a community-driven study
    M E Northridge
    Harlem Center for Health Promotion and Disease Prevention, New York, NY, USA
    Am J Public Health 89:998-1002. 1999
    ..This study sought individual-level data on diesel exhaust exposure and lung function among adolescents in Harlem as part of a community-driven research agenda...
  70. ncbi DNA damage in T- and B-lymphocytes and granulocytes in emission inspection and incineration workers exposed to polycyclic aromatic hydrocarbons
    Donggeun Sul
    Department of Preventive Medicine, College of Medicine and Institute for Environmental Health, Medical Science Research Center, Korea University, Seoul, South Korea
    Mutat Res 538:109-19. 2003
    ..A comparison of DNA damage in three groups showed that B-lymphocytes are useful target in the biomonitoring of human exposure...
  71. ncbi Pyrene-labeled lipids as tools in membrane biophysics and cell biology
    Pentti Somerharju
    Institute of Biomedicine, Biomedicum, Room C205b, Haartmaninkatu 8, P O Box 63, University of Helsinki, 00014 Helsinki, Finland
    Chem Phys Lipids 116:57-74. 2002
    ..The main disadvantage of pyrene lipids is the relatively large size of the fluorophore. Another disadvantage is that they require UV-excitation, which is not feasible with all microscopes...
  72. ncbi The effect of relevant genotypes on PAH exposure-related biomarkers
    Terhi Kuljukka-Rabb
    Institute of Occupational Health, FIN 00250 Helsinki, Finland
    J Expo Anal Environ Epidemiol 12:81-91. 2002
    ..Even at high exposures metabolic polymorphisms seem to have some effect on biomarker levels, and should be assessed in biomonitoring studies...
  73. ncbi Associations between exposure to polycyclic aromatic hydrocarbons and temporal change of urinary 1-hydroxypyrene levels in Taiwanese coke-oven workers
    Ying Chu Lin
    Graduate Institute of Dental Science, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Occup Environ Med 48:930-6. 2006
    ..Our aim is to analyze the association between polycyclic aromatic hydrocarbon (PAH) exposure and the temporal change of urinary 1-hydroxypyrene (1-OHP)...
  74. pmc Urinary 1-hydroxypyrene in coke oven workers relative to exposure, alcohol consumption, and metabolic enzymes
    J Zhang
    Department of Community Health Science, Saga Medical School, Saga 849 8501, Japan
    Occup Environ Med 58:716-21. 2001
    ....
  75. ncbi Urinary excretion of 8-hydroxy-2-deoxyguanosine and 1-hydroxypyrene in coke-oven workers
    Ming Tsang Wu
    Graduate Institute of Occupational Safety and Health and Department of Occupational Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Environ Mol Mutagen 42:98-105. 2003
    ..02). Our findings suggest that urinary 1-OHP and 8-OH-dG reflect occupational PAH exposure and oxidative DNA damage in COWs. In addition, multiple vitamins may reduce oxidative stress caused by PAH exposure...
  76. pmc Using pyrene-labeled HIV-1 TAR to measure RNA-small molecule binding
    Kenneth F Blount
    Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0358, USA
    Nucleic Acids Res 31:5490-500. 2003
    ..We conclude that this newly developed assay can be generalized to measure the binding affinities and selectivities of a variety of small molecules to a specific RNA target...
  77. ncbi Impact of metabolic genotypes on levels of biomarkers of genotoxic exposure
    B Schoket
    Department of Biochemistry, National Institute of Environmental Health, József Fodor National Centre for Public Health, Budapest H 1097, Hungary
    Mutat Res 482:57-69. 2001
    ....
  78. ncbi Effects of occupation, lifestyle and genetic polymorphisms of CYP1A1, CYP2E1, GSTM1 and GSTT1 on urinary 1-hydroxypyrene and 2-naphthol concentrations
    H M Nan
    Department of Preventive Medicine, College of Medicine, Chungbuk National University, South Korea
    Carcinogenesis 22:787-93. 2001
    ..In individuals not occupationally exposed to PAHs GSTM1 and smoking seem to influence the urinary concentration of 2-naphthol...
  79. pmc 5'-bis-pyrenylated oligonucleotides displaying excimer fluorescence provide sensitive probes of RNA sequence and structure
    E Kostenko
    Novosibirsk Institute of Bioorganic Chemistry, Lavrentiev Avenue 8, Novosibirsk 630090, Russia
    Nucleic Acids Res 29:3611-20. 2001
    ..Potentially, these conjugates may be considered as fluorescent probes for RNA structure investigation...
  80. ncbi RNA tertiary folding monitored by fluorescence of covalently attached pyrene
    S K Silverman
    Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of Colorado at Boulder 80309 0215, USA
    Biochemistry 38:14224-37. 1999
    ....
  81. ncbi The effect of coal stoves and environmental tobacco smoke on the level of urinary 1-hydroxypyrene
    E Siwinska
    Institute of Occupational Medicine and Environmental Health, Sosnowiec, Poland
    Mutat Res 445:147-53. 1999
    ..When the results associated with this kind of exposure were excluded, median 1-OH-PY levels from the three examined areas assumed a pattern more similar to that of the benzo(a)pyrene (BaP) concentrations in ambient air...
  82. ncbi Locked nucleic acids and intercalating nucleic acids in the design of easily denaturing nucleic acids: thermal stability studies
    Vyacheslav V Filichev
    Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark
    Chembiochem 5:1673-9. 2004
    ..When two INA monomers were inserted into the stem of the LNA hairpin, the same experiment resulted in a significant hyperchromicity comparable with the one obtained for the corresponding DNA/DNA duplex...
  83. ncbi Exposure to genotoxins present in ambient air in Bangkok, Thailand--particle associated polycyclic aromatic hydrocarbons and biomarkers
    Mathuros Ruchirawa
    Laboratory of Environmental Toxicology, Chulabhorn Research Institute, Bangkok, Thailand
    Sci Total Environ 287:121-32. 2002
    ..However, for people who spend their working day in offices, the exposure is similar to people living in other metropolitan areas...
  84. ncbi Effects of genetic polymorphisms in metabolic enzymes on the relationships between 8-hydroxydeoxyguanosine levels in human leukocytes and urinary 1-hydroxypyrene and 2-naphthol concentrations
    Yong Dae Kim
    Department of Preventive Medicine, College of Medicine, Chungbuk National University, South Korea
    J Occup Health 45:160-7. 2003
    ..This relationship is affected by genetic polymorphisms in PAH metabolic enzymes...
  85. ncbi A pyrene-labeled G-quadruplex oligonucleotide as a fluorescent probe for potassium ion detection in biological applications
    Satoru Nagatoishi
    Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka 812 858, Japan
    Angew Chem Int Ed Engl 44:5067-70. 2005
  86. ncbi DNA strand breaks, oxidative damage, and 1-OH pyrene in roofers with coal-tar pitch dust and/or asphalt fume exposure
    M Toraason
    National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA
    Int Arch Occup Environ Health 74:396-404. 2001
    ..The increase in urinary 8OHdG coupled with the decrease in leukocyte 8-OHdG/dG, suggests that coal-tar exposure induces protective or repair mechanisms that result in reduced levels of steady-state oxidative-DNA damage...
  87. ncbi Detection of acceptor sites for antisense oligonucleotides on native folded RNA by fluorescence spectroscopy
    Atsushi Mahara
    Department of Polymer Science and Engineering, Kyoto Institute of Technology, Matsugasaki, Kyoto 606 8585, Japan
    Bioorg Med Chem 11:2783-90. 2003
    ..These results indicated that the site targeted by OMUpy-8 was exposed to regulatory molecules, and suggest that the method presented here is useful to design antisense molecules...
  88. ncbi Urinary 1-hydroxypyrene and t,t-muconic acid as biomarkers of exposure to environmental pollutants in two areas in Italy (EPIC-Florence and Ragusa)
    Calogero Saieva
    Molecular and Nutritional Epidemiology Unit, CSPO, Scientific Institute of Tuscany, Florence, Italy
    Tumori 89:679-86. 2003
    ..Int J Cancer, 87: 444-451, 2000) and showed that mean DNA adduct levels varied considerably among different centers, being highest in Florence (a large metropolitan area in Tuscany) and lowest in Ragusa (a small town in Sicily)...
  89. ncbi [Environmental and biological monitoring of exposure to polycyclic aromatic hydrocarbons in workers of an electric steel foundry]
    E Bergamaschi
    Dipartimento di Clinica Medica, Nefrologia e Scienze della Prevenzione, Sezione di Medicina del Lavoro e Tossicologia Industriale, Universita degli Studi di Parma
    Med Lav 96:390-402. 2005
    ..To assess and classify exposure to Polycyclic Aromatic Hydrocarbons (PAHs) in some specific working areas of a steel foundry operating with a continuous casting process and evaluate biomonitoring data in different job tasks...
  90. ncbi [Effects of co-substrates on biodegradation of pyrene by ten bacterial strains]
    Dan Su
    Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China
    Ying Yong Sheng Tai Xue Bao 18:636-40. 2007
    ..8%. For SB04 and SB09, the biodegradation rate of PYR had no significant difference between MS1 and MS2, but for other strains, the stimulation effect of phenanthrene on PYR degradation was higher than that of glucose...
  91. pmc Characterization of cultures enriched from acidic polycyclic aromatic hydrocarbon-contaminated soil for growth on pyrene at low pH
    Maarten Uyttebroek
    Division Soil and Water Management, Catholic University of Leuven, Kasteelpark Arenberg 20, B 3001 Leuven, Belgium
    Appl Environ Microbiol 73:3159-64. 2007
    ..Our data indicate that a slow-growing Mycobacterium species is involved in PAH degradation in that culture and show that bacteria able to degrade high-molecular-weight PAHs at low pH are present in acidic PAH-contaminated soil...
  92. ncbi The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers
    Bo Chen
    Department of Occupational Health and Toxicology, School of Public Health, Fudan University, Shanghai, 200032, PR China
    Sci Total Environ 381:38-46. 2007
    ..No influence was found in the association between urinary 1-OHP and other genetic polymorphisms such as CYP1A1, CYP1A2, CYP1B1, CYP2E1, EPHX1, EPHX2 in this population...
  93. doi Direct and indirect photolysis of polycyclic aromatic hydrocarbons in nitrate-rich surface waters
    Laura E Jacobs
    Environmental Science Graduate Program, The Ohio State University, Columbus, Ohio 43210, USA
    Environ Toxicol Chem 27:1643-8. 2008
    ..Overall photoreaction rates decreased for the lower-molecular-weight PAHs, because the fastest naphthalene photolytic rate was roughly two orders of magnitude slower than that of pyrene...
  94. ncbi Urinary hydroxylated metabolites of polycyclic aromatic hydrocarbons as biomarkers of exposure in asphalt workers
    M Buratti
    Department of Occupational and Environmental Health, University of Milan and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via S Barnaba, Milan, Italy
    Biomarkers 12:221-39. 2007
    ..Fumes and vapours released during laying of hot asphalt mix have been recognised as a major source of exposure for asphalt workers...
  95. ncbi Selection and identification of bacteria isolated from waste crude oil with polycyclic aromatic hydrocarbons removal capacities
    F L Toledo
    Group of Environmental Microbiology, Department of Microbiology, Institute of Water Research, University of Granada, c Ramón y Cajal n 4, Edificio Fray Luis de Granada, 18071 Granada, Spain
    Syst Appl Microbiol 29:244-52. 2006
    ..Finally, the capacity of certain strains to emulsify octane, xilene, toluene, mineral oil and crude oil, and its ability to remove hydrocarbons, look promising for its application in bioremediation technologies...
  96. ncbi Identification of polycyclic aromatic hydrocarbons (PAHs) in suspended particulate matter by synchronous fluorescence spectroscopic technique
    Homdutt Sharma
    Department of Physics, Jamia Millia Islamia, Jamia Nagar, New Delhi 110 025, India
    Spectrochim Acta A Mol Biomol Spectrosc 68:43-9. 2007
    ..This is in agreement with our earlier work for determination of these PAHs using gas chromatography (GC). The seasonal variation of the PAHs was found to be maximum in winter and minimum during the monsoon...
  97. ncbi Differential responses of eubacterial, Mycobacterium, and Sphingomonas communities in polycyclic aromatic hydrocarbon (PAH)-contaminated soil to artificially induced changes in PAH profile
    Maarten Uyttebroek
    Division of Soil and Water Management, Catholic University of Leuven, Kasteelpark Arenberg 20, B 3001 Leuven, Belgium
    J Environ Qual 36:1403-11. 2007
    ....
  98. ncbi The distribution and sources of polycyclic aromatic hydrocarbons in surface sediments along the Egyptian Mediterranean coast
    Ahmed El Nemr
    Environmental Division, National Institute of Oceanography and Fisheries, Kayet Bay, Alexandria, Egypt
    Environ Monit Assess 124:343-59. 2007
    ..Interferences of rather petrogenic and pyrolytic PAH contaminations were noticed in the harbors due to petroleum products deliveries and fuel combustion emissions from the ships staying alongside the quays...
  99. ncbi Spatial distribution and sources of polycyclic aromatic hydrocarbons (PAHs) in soils from typical oil-sewage irrigation area, Northeast China
    Xiaojun Li
    Institute of Applied Ecology, Chinese Academy of Sciences, P O Box 417, Wenhua Road 72, Shenyang 110016, Peoples Republic of China
    Environ Monit Assess 143:257-65. 2008
    ....
  100. ncbi External and internal exposure to polycyclic aromatic hydrocarbons (PAH) among workers in the production of fire-proof materials - proposal of a biological monitoring guidance value
    Ralf Preuss
    University of Erlangen Nuremberg, Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Erlangen, Germany
    Int J Hyg Environ Health 209:575-80. 2006
    ..The following BMGVs for the non-smokers of this branch of industry are proposed: for 1-hydroxypyrene 18microg/g creatinine and for the sum of hydroxyphenanthrenes 77microg/g creatinine in urine measured at the end of the shift...
  101. doi Uptake of selected PAHs from contaminated soils by rice seedlings (Oryza sativa) and influence of rhizosphere on PAH distribution
    Yu Hong Su
    Chemistry Department, Xinjiang University, Urumqi 830046, China
    Environ Pollut 155:359-65. 2008
    ..24 and 14%, respectively, based on PYR concentrations in rhizosphere and non-rhizosphere soils, the biomass of rice roots, and the dry soil weight...

Research Grants69

  1. Interventions for Tobacco Dependent Adolescents
    Dorothy Hatsukami; Fiscal Year: 2005
    ....
  2. BIOLOGICAL EFFECTS OF DNA ADDUCTS FORMED BY NITROPYRENES
    ASHIS BASU; Fiscal Year: 2002
    ..objective of this research is to investigate the mechanism of mutagenesis and DNA repair induced by the nitrated pyrenes that are known environmental pollutants and are suspected to pose threats to human health...
  3. BIOLOGICAL EFFECTS OF DNA ADDUCTS FORMED BY NITROPYRENES
    ASHIS BASU; Fiscal Year: 2006
    ..objective of this research is to investigate the mechanism of mutagenesis and DNA repair induced by the nitrated pyrenes that are known environmental pollutants and are suspected to pose threats to human health...
  4. INDEPENDENT SCIENTIST AWARD (NIEHS)
    ASHIS BASU; Fiscal Year: 2002
    ..of this current research is to investigate the mechanisms of mutagenesis and DNA repair induced by the nitrated pyrenes. To accomplish this goal, his laboratory has used the tools of organic synthesis and recombinant DNA technology ..
  5. Allosteric DNAzyme sensors for practical detection of mycotoxins
    SCOTT SILVERMAN; Fiscal Year: 2007
    ..Improved sensors for detecting mycotoxins and thereby revealing the presence of fungi will allow proper remedial actions to be taken. ..
  6. REACTIVE INTERMEDIATES OF CARCINOGENESIS OF PAHS
    KENNETH LAALI; Fiscal Year: 2004
    ..DNA binding and mammalian cell mutagenicity studies on the substituted and derivatized-PAHs proposed for stable ion work will enhance the available literature data on structure/reactivity relationships. ..
  7. Body Burden of PAHs and Cardiovascular Disease in the United States
    John Clark; Fiscal Year: 2007
    ..Results of this proposed study can be used to influence policy decisions and resource allocation for the prevention of cardiovascular disease. ..
  8. Novel Determinants and Measures of Smokeless Tobacco Use
    Dorothy K Hatsukami; Fiscal Year: 2010
    ..This study would demonstrate the feasibility and impact of switching ST users to less toxic ST products. Together, these studies will help to guide important policy decisions to reduce the toll of tobacco-related disease. ..
  9. A Request for support of 25th SPRSM Meeting
    James Wang; Fiscal Year: 2006
    ....
  10. Evaluation of Oral Tobacco as a Harm Reduction Method for Smokers
    Dorothy K Hatsukami; Fiscal Year: 2010
    ..The results from these studies will help determine the effects and feasibility of using oral tobacco products as both a cessation aid and a method to reduce individual health risk in cigarette smokers. ..
  11. Perfluorooctane sulfonate (PFOS) Affects Immunity through PPAR-alpha.
    Margie Peden Adams; Fiscal Year: 2007
    ..In Experiment B mice will not be immunized. The unimmunized and immunized experiments will be conducted to control for possible differences in response related to lymphocyte activation from the immunization. ..
  12. Evaluation of urinary 1-nitropyrene metabolities as a biomarker for exposure to d
    Christopher Simpson; Fiscal Year: 2007
    ....
  13. Development and validation of a woodsmoke biomarker in urine
    Christopher Simpson; Fiscal Year: 2007
    ....
  14. Evaluation of Oral Tobacco as a Harm Reduction Method for Smokers
    Dorothy Hatsukami; Fiscal Year: 2009
    ..The results from these studies will help determine the effects and feasibility of using oral tobacco products as both a cessation aid and a method to reduce individual health risk in cigarette smokers. ..
  15. Innovative Interventions for Smoking Cessation
    Dorothy Hatsukami; Fiscal Year: 2009
    ..The results of this study will provide useful information on directions to pursue to improve our pharmacotherapies and behavioral treatments and to better understand the various aspects of addiction. ..
  16. Factors influencing regulation of the dynamics of the actin filament pointed end
    Alla Kostyukova; Fiscal Year: 2009
    ..The information obtained in this study will help us to understand the formation of the capping complex at the pointed end and its function in regulating dynamics of the actin filament in cells and tissues. ..
  17. Factors influencing regulation of the dynamics of the actin filament pointed end
    Alla S Kostyukova; Fiscal Year: 2010
    ..The information obtained in this study will help us to understand the formation of the capping complex at the pointed end and its function in regulating dynamics of the actin filament in cells and tissues. ..
  18. TOBACCO EXPOSURE REDUCTION
    Dorothy Hatsukami; Fiscal Year: 2007
    ..The results of research from this TTURC will provide the scientific basis for urgent policy, public education, and regulatory efforts to reduce tobacco harm. ..
  19. Quantifying Biosynthesized Porphyrins and Complexes
    MARK SCHLAUTMAN; Fiscal Year: 2004
    ..The CL detection systems developed for ion-pair HPLC in this project will ultimately find use as powerful new detection systems for micro-chip, nano-chip, and microarray applications. ..
  20. A Multidisciplinary Study of Mechanisms for Tendinitis
    James Wang; Fiscal Year: 2005
    ..The findings from this study will also be useful in helping design experiments to study other repetitive motion disorders (e.g., carpal tunnel syndrome). ..
  21. STAR POLYMER UNIMOLECULAR MICELLES FOR DRUG DELIVERY
    Fei Wang; Fiscal Year: 2004
    ..abstract_text> ..
  22. TIMING OF SMOKING INTERVENTION IN ALCOHOL TREATMENT
    ANNE JOSEPH; Fiscal Year: 2001
    ....
  23. Semiconductor Nanocrystals for Biomedical Imaging
    Fei Wang; Fiscal Year: 2005
    ..Both types of encapsulated nanoparticle probes will be used to transfect cultured mammalian cells in order to assess QD luminescence in a physiological milieu. ..
  24. BRANCHED COPOLYMER AS PEPTIDE DRUG DELIVERY SYSTEM
    Fei Wang; Fiscal Year: 2006
    ..New drug delivery systems have had an impact on nearly every branch of medicine. Controlled drug delivery is a $20 billion industry and rising rapidly...