pyrenes

Summary

Summary: A group of condensed ring hydrocarbons.

Top Publications

  1. ncbi Rapid quantification of polycyclic aromatic hydrocarbons in hydroxypropyl-beta-cyclodextrin (HPCD) soil extracts by synchronous fluorescence spectroscopy (SFS)
    Guoxiong Hua
    School of Biology and Psychology, Institute for Research on Environment and Sustainability, Newcastle University, Newcastle upon Tyne, UK
    Environ Pollut 148:176-81. 2007
  2. ncbi Seasonal variations in spontaneous levels of DNA damage; implication in the risk assessment of environmental chemicals
    L Verschaeve
    VITO, Environmental Toxicology, Boeretang 200, B 2400 Mol, Belgium
    J Appl Toxicol 27:612-20. 2007
  3. ncbi Aldo-keto reductase 1C2 is essential for 1-nitropyrene's but not for benzo[a]pyrene's induction of p53 phosphorylation and apoptosis
    Jyan Gwo J Su
    Department of Biochemical Science and Technology, College of Life Sciences, National Chiayi University, Chiayi 600, Taiwan
    Toxicology 244:257-70. 2008
  4. ncbi Nitrogen gas purging for the deoxygenation of polyaromatic hydrocarbon solutions in cyclohexane for routine fluorescence analysis
    Todd Pagano
    Department of Science and Mathematics, Laboratory Science Technology Program, Rochester Institute of Technology, National Technical Institute for the Deaf, 52 Lomb Memorial Drive, Rochester, New York 14623, USA
    Appl Spectrosc 62:333-6. 2008
  5. ncbi Intercalating nucleic acids containing insertions of 1-O-(1-pyrenylmethyl)glycerol: stabilisation of dsDNA and discrimination of DNA over RNA
    Ulf B Christensen
    Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, DK-5230 Odense M, Denmark
    Nucleic Acids Res 30:4918-25. 2002
  6. ncbi High exposure to polycyclic aromatic hydrocarbons may contribute to high risk of esophageal cancer in northeastern Iran
    Farin Kamangar
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 21218, USA
    Anticancer Res 25:425-8. 2005
  7. ncbi Biological monitoring of exposure to mixtures
    Claude Viau
    Human Toxicology Research Group, Department of Environmental and Occupational Health, University of Montreal, QC, Canada
    Toxicol Lett 134:9-16. 2002
  8. ncbi Pyrene is highly emissive when attached to the RNA duplex but not to the DNA duplex: the structural basis of this difference
    Mitsunobu Nakamura
    Department of Materials Science and Chemistry, University of Hyogo, 2167 Shosha, Himeji, Hyogo 671-2201, Japan
    Nucleic Acids Res 33:5887-95. 2005
  9. ncbi Urinary 1-hydroxypyrene and 2-naphthol concentrations in male Koreans
    H Kim
    Department of Preventive Medicine, College of Medicine, Chungbuk National University, 48 San Kaeshin dong, Hungdok gu, Cheongju, Chungbuk 361 763, S Korea
    Int Arch Occup Environ Health 74:59-62. 2001
  10. ncbi Integrity of duplex structures without hydrogen bonding: DNA with pyrene paired at abasic sites
    Serge Smirnov
    Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, NY 11794-8651, USA
    Nucleic Acids Res 30:5561-9. 2002

Research Grants

  1. Interventions for Tobacco Dependent Adolescents
    Dorothy Hatsukami; Fiscal Year: 2005
  2. BIOLOGICAL EFFECTS OF DNA ADDUCTS FORMED BY NITROPYRENES
    ASHIS BASU; Fiscal Year: 2002
  3. BIOLOGICAL EFFECTS OF DNA ADDUCTS FORMED BY NITROPYRENES
    ASHIS BASU; Fiscal Year: 2006
  4. INDEPENDENT SCIENTIST AWARD (NIEHS)
    ASHIS BASU; Fiscal Year: 2002
  5. REACTIVE INTERMEDIATES OF CARCINOGENESIS OF PAHS
    KENNETH LAALI; Fiscal Year: 2004
  6. Allosteric DNAzyme sensors for practical detection of mycotoxins
    SCOTT SILVERMAN; Fiscal Year: 2007
  7. Development and validation of a woodsmoke biomarker in urine
    Christopher Simpson; Fiscal Year: 2007
  8. A Request for support of 25th SPRSM Meeting
    James Wang; Fiscal Year: 2006
  9. Perfluorooctane sulfonate (PFOS) Affects Immunity through PPAR-alpha.
    Margie Peden Adams; Fiscal Year: 2007
  10. Evaluation of urinary 1-nitropyrene metabolities as a biomarker for exposure to d
    Christopher Simpson; Fiscal Year: 2007

Detail Information

Publications186 found, 100 shown here

  1. ncbi Rapid quantification of polycyclic aromatic hydrocarbons in hydroxypropyl-beta-cyclodextrin (HPCD) soil extracts by synchronous fluorescence spectroscopy (SFS)
    Guoxiong Hua
    School of Biology and Psychology, Institute for Research on Environment and Sustainability, Newcastle University, Newcastle upon Tyne, UK
    Environ Pollut 148:176-81. 2007
    ..Hence, SFS is a potential means to simplify the present non-exhaustive hydroxypropyl-beta-cyclodextrin (HPCD)-based extraction technique for the evaluation of PAH bioavailability in soil...
  2. ncbi Seasonal variations in spontaneous levels of DNA damage; implication in the risk assessment of environmental chemicals
    L Verschaeve
    VITO, Environmental Toxicology, Boeretang 200, B 2400 Mol, Belgium
    J Appl Toxicol 27:612-20. 2007
    ..The investigation confirms that the blood sampling period is crucial in the planning and interpretation of biomonitoring studies...
  3. ncbi Aldo-keto reductase 1C2 is essential for 1-nitropyrene's but not for benzo[a]pyrene's induction of p53 phosphorylation and apoptosis
    Jyan Gwo J Su
    Department of Biochemical Science and Technology, College of Life Sciences, National Chiayi University, Chiayi 600, Taiwan
    Toxicology 244:257-70. 2008
    ..The metabolic and signaling pathways for the toxic effects of both 1-NP and B[a]P are similar except that AKR1C2 plays differential role between them. The results provide valuable information for further investigations on AKRs...
  4. ncbi Nitrogen gas purging for the deoxygenation of polyaromatic hydrocarbon solutions in cyclohexane for routine fluorescence analysis
    Todd Pagano
    Department of Science and Mathematics, Laboratory Science Technology Program, Rochester Institute of Technology, National Technical Institute for the Deaf, 52 Lomb Memorial Drive, Rochester, New York 14623, USA
    Appl Spectrosc 62:333-6. 2008
    ..61 +/- 0.02, 4.17 +/- 0.02, 7.63 +/- 0.07, and 21.81 +/- 0.35, respectively...
  5. ncbi Intercalating nucleic acids containing insertions of 1-O-(1-pyrenylmethyl)glycerol: stabilisation of dsDNA and discrimination of DNA over RNA
    Ulf B Christensen
    Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, DK-5230 Odense M, Denmark
    Nucleic Acids Res 30:4918-25. 2002
    ..Fluorescence measurements show a stronger interaction of the pyrene moiety with DNA than with RNA, indicating intercalation as the stabilising factor in DNA/INA duplexes...
  6. ncbi High exposure to polycyclic aromatic hydrocarbons may contribute to high risk of esophageal cancer in northeastern Iran
    Farin Kamangar
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 21218, USA
    Anticancer Res 25:425-8. 2005
    ..The northeastern region of Iran has some of the highest rates of esophageal squamous cell carcinoma (ESCC) in the world...
  7. ncbi Biological monitoring of exposure to mixtures
    Claude Viau
    Human Toxicology Research Group, Department of Environmental and Occupational Health, University of Montreal, QC, Canada
    Toxicol Lett 134:9-16. 2002
    ..Finally, there is clearly a need for a greater research effort on the toxicology of mixtures to make biological monitoring a useful tool in occupational health...
  8. ncbi Pyrene is highly emissive when attached to the RNA duplex but not to the DNA duplex: the structural basis of this difference
    Mitsunobu Nakamura
    Department of Materials Science and Chemistry, University of Hyogo, 2167 Shosha, Himeji, Hyogo 671-2201, Japan
    Nucleic Acids Res 33:5887-95. 2005
    ..Molecular dynamics simulations support these differences in the local structural elements around the pyrene between the pyrene-RNA/RNA and the pyrene-DNA/DNA duplexes...
  9. ncbi Urinary 1-hydroxypyrene and 2-naphthol concentrations in male Koreans
    H Kim
    Department of Preventive Medicine, College of Medicine, Chungbuk National University, 48 San Kaeshin dong, Hungdok gu, Cheongju, Chungbuk 361 763, S Korea
    Int Arch Occup Environ Health 74:59-62. 2001
    ..We analyzed urinary 1-OHP and 2-naphthol concentrations in 292 male Koreans (129 university students and 163 shipyard workers) to define the distribution pattern in Koreans with no or low occupational exposure to PAHs...
  10. ncbi Integrity of duplex structures without hydrogen bonding: DNA with pyrene paired at abasic sites
    Serge Smirnov
    Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, NY 11794-8651, USA
    Nucleic Acids Res 30:5561-9. 2002
    ..The results support the idea that the stability and replication of a P.F pair is due to its ability to mimic Watson-Crick structure...
  11. ncbi Modulation of pyrene fluorescence in DNA probes depends upon the nature of the conformationally restricted nucleotide
    Dmytro Honcharenko
    Department of Bioorganic Chemistry, Box 581, Biomedical Center, Uppsala University, SE 75123 Uppsala, Sweden
    J Org Chem 73:2829-42. 2008
    ..Our data corroborate that the pyrene moiety is intercalated in the X-modified mismatched ODN/RNA (G mismatch) heteroduplex as compared to that of the Y-modified ODN/RNA (G mismatch) heteroduplex, in which it is located outside the helix...
  12. ncbi Bis-pyrene-labeled oligonucleotides: sequence specificity of excimer and monomer fluorescence changes upon hybridization with DNA
    Kazushige Yamana
    Department of Applied Chemistry, Himeji Institute of Technology, 2167 Shosha, Himeji, Hyogo 671 2201, Japan
    Bioconjug Chem 13:1266-73. 2002
    ..The excimer and monomer fluorescence changes were found to be sensitive to a mismatch base present in the target DNA. The bis-pyrene-modified ODNs thus provide a sequence-sepcific fluorescent probe of DNA...
  13. ncbi Associations between exposure to polycyclic aromatic hydrocarbons and temporal change of urinary 1-hydroxypyrene levels in Taiwanese coke-oven workers
    Ying-Chu Lin
    Graduate Institute of Dental Science, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Occup Environ Med 48:930-6. 2006
    ..CONCLUSIONS: We suggest that the pattern of temporal change of urinary 1-OHP levels is different between topside-oven and side-oven workers...
  14. ncbi Urinary excretion of 8-hydroxy-2-deoxyguanosine and 1-hydroxypyrene in coke-oven workers
    Ming Tsang Wu
    Graduate Institute of Occupational Safety and Health and Department of Occupational Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Environ Mol Mutagen 42:98-105. 2003
    ..02). Our findings suggest that urinary 1-OHP and 8-OH-dG reflect occupational PAH exposure and oxidative DNA damage in COWs. In addition, multiple vitamins may reduce oxidative stress caused by PAH exposure...
  15. ncbi Influence of genetic polymorphisms of CYP1A1 and GSTM1 on the urinary levels of 1-hydroxypyrene
    P Apostoli
    Chair of Industrial Hygiene, Department of Experimental and Applied Medicine, University of Brescia, P le Spedali Civili, 1, Brescia 25123, Italy
    Toxicol Lett 144:27-34. 2003
    ..No influence of the genetic polymorphism of CYP1A1 and GSTM1 on the urinary levels of 1-OH-P was observed in this study...
  16. ncbi Plant-accelerated dissipation of phenanthrene and pyrene from water in the presence of a nonionic-surfactant
    Yanzheng Gao
    College of Resource and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China
    Chemosphere 63:1560-7. 2006
    ..Results obtained from this study provided some insight with regard to the feasibility of phytoremediation for PAH contaminated water bodies with coexisted contaminants of surfactants...
  17. ncbi Elevated concentrations of 1-hydroxypyrene in schoolchildren during winter in Christchurch, New Zealand
    Jo Anne E Cavanagh
    Landcare Research, PO Box 40, Lincoln 7640, New Zealand
    Sci Total Environ 374:51-9. 2007
    ....
  18. ncbi Using pyrene-labeled HIV-1 TAR to measure RNA-small molecule binding
    Kenneth F Blount
    Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358, USA
    Nucleic Acids Res 31:5490-500. 2003
    ..We conclude that this newly developed assay can be generalized to measure the binding affinities and selectivities of a variety of small molecules to a specific RNA target...
  19. ncbi 2H-NMR study and molecular dynamics simulation of the location, alignment, and mobility of pyrene in POPC bilayers
    Barbara Hoff
    IMVM, Bioprocess Engineering, University of Karlsruhe, 76131 Karlsruhe, Germany
    Biophys J 88:1818-27. 2005
    ..The good agreement can be explained by the fact that the different kind of motions of a pyrene molecule are already averaged within a few nanoseconds, which is the timescale covered by the MD simulation...
  20. ncbi Associations between XRCC1 and ERCC2 polymorphisms and DNA damage in peripheral blood lymphocyte among coke oven workers
    Shuguang Leng
    National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China
    Biomarkers 9:395-406. 2004
    ....
  21. ncbi Urinary 1-hydroxypyrene in children living in city and rural residences in Denmark
    Ase Marie Hansen
    National Institute of Occupational Health, Copenhagen Ø, Denmark
    Sci Total Environ 347:98-105. 2005
    ..The present study aims to assess the biological uptake in children of polycyclic aromatic hydrocarbons measured as 1-hydroxypyrene in urine from children living in city and rural residences...
  22. ncbi Plant uptake, accumulation and translocation of phenanthrene and pyrene in soils
    Yanzheng Gao
    Department of Environmental Sciences, Zhejiang University, Hangzhou 310028, China
    Chemosphere 55:1169-78. 2004
    ..24% for pyrene in planted versus unplanted control soils, whereas plant-promoted biodegradation was the predominant contribution of remediation enhancement of soil phenanthrene and pyrene in the presence of vegetation...
  23. ncbi Association between urinary 1-hydroxypyrene and genotoxic effects in coke oven workers
    E Siwinska
    Institute of Occupational Medicine and Environmental Health, 13 Koscielna St, 41 200 Sosnowiec, Poland
    Occup Environ Med 61:e10. 2004
    ....
  24. ncbi Stable and selective formation of hoogsteen-type triplexes and duplexes using twisted intercalating nucleic acids (TINA) prepared via postsynthetic Sonogashira solid-phase coupling reactions
    Vyacheslav V Filichev
    Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark
    J Am Chem Soc 127:14849-58. 2005
    ..0 degrees C at pH 7.2, while the T(m) of unmodified dsDNA was 47.0 degrees C. Experiments with mismatched oligonucleotides, luminescent properties, and potential applications of TINA technology is discussed...
  25. ncbi [An improved high performance liquid chromatography method for determination of 1-hydroxypyrene in urine]
    Xiaohua Li
    National Institute of Occupational Medicine and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China
    Wei Sheng Yan Jiu 32:616-7. 2003
    ..This method is sensitive, efficient and reliable, and was successfully used for the determination of 1-hydroxypyrene in urine of workers exposed to polycyclic aromatic hydrocarbon...
  26. ncbi Adsorption of polycyclic aromatic hydrocarbons by carbon nanomaterials
    Kun Yang
    Department of Plant, Soil and Insect Sciences, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Environ Sci Technol 40:1855-61. 2006
    ..In addition, high adsorption capacity of PAHs by carbon nanotubes may add to their high environmental risks once released to the environment, and result in potential alteration of PAHs fate and bioavailability in the environment...
  27. ncbi Application of the partition-limited model for plant uptake of organic chemicals from soil and water
    Yanzheng Gao
    Department of Environmental Sciences, Zhejiang University, Hangzhou 310028, China
    Sci Total Environ 336:171-82. 2005
    ..05, n = 10). This investigation substantiated the concept of the partition-limited model and its utility for vegetation-uptake assessment...
  28. ncbi Pyrene-labeled lipids as tools in membrane biophysics and cell biology
    Pentti Somerharju
    Institute of Biomedicine, Biomedicum, Room C205b, Haartmaninkatu 8, P O Box 63, University of Helsinki, 00014 Helsinki, Finland
    Chem Phys Lipids 116:57-74. 2002
    ..The main disadvantage of pyrene lipids is the relatively large size of the fluorophore. Another disadvantage is that they require UV-excitation, which is not feasible with all microscopes...
  29. ncbi Effects of occupation, lifestyle and genetic polymorphisms of CYP1A1, CYP2E1, GSTM1 and GSTT1 on urinary 1-hydroxypyrene and 2-naphthol concentrations
    H M Nan
    Department of Preventive Medicine, College of Medicine, Chungbuk National University, South Korea
    Carcinogenesis 22:787-93. 2001
    ..In individuals not occupationally exposed to PAHs GSTM1 and smoking seem to influence the urinary concentration of 2-naphthol...
  30. ncbi RNA tertiary folding monitored by fluorescence of covalently attached pyrene
    S K Silverman
    Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of Colorado at Boulder 80309 0215, USA
    Biochemistry 38:14224-37. 1999
    ....
  31. ncbi 5'-bis-pyrenylated oligonucleotides displaying excimer fluorescence provide sensitive probes of RNA sequence and structure
    E Kostenko
    Novosibirsk Institute of Bioorganic Chemistry, Lavrentiev Avenue 8, Novosibirsk 630090, Russia
    Nucleic Acids Res 29:3611-20. 2001
    ..Potentially, these conjugates may be considered as fluorescent probes for RNA structure investigation...
  32. ncbi Impact of metabolic genotypes on levels of biomarkers of genotoxic exposure
    B Schoket
    Department of Biochemistry, National Institute of Environmental Health, József Fodor National Centre for Public Health, Budapest H 1097, Hungary
    Mutat Res 482:57-69. 2001
    ....
  33. ncbi The effect of relevant genotypes on PAH exposure-related biomarkers
    Terhi Kuljukka-Rabb
    Institute of Occupational Health, FIN 00250 Helsinki, Finland
    J Expo Anal Environ Epidemiol 12:81-91. 2002
    ..Even at high exposures metabolic polymorphisms seem to have some effect on biomarker levels, and should be assessed in biomonitoring studies...
  34. ncbi Urinary 1-hydroxypyrene in coke oven workers relative to exposure, alcohol consumption, and metabolic enzymes
    J Zhang
    Department of Community Health Science, Saga Medical School, Saga 849 8501, Japan
    Occup Environ Med 58:716-21. 2001
    ....
  35. ncbi The effect of coal stoves and environmental tobacco smoke on the level of urinary 1-hydroxypyrene
    E Siwinska
    Institute of Occupational Medicine and Environmental Health, Sosnowiec, Poland
    Mutat Res 445:147-53. 1999
    ..When the results associated with this kind of exposure were excluded, median 1-OH-PY levels from the three examined areas assumed a pattern more similar to that of the benzo(a)pyrene (BaP) concentrations in ambient air...
  36. ncbi Diesel exhaust exposure among adolescents in Harlem: a community-driven study
    M E Northridge
    Harlem Center for Health Promotion and Disease Prevention, New York, NY, USA
    Am J Public Health 89:998-1002. 1999
    ..This study sought individual-level data on diesel exhaust exposure and lung function among adolescents in Harlem as part of a community-driven research agenda...
  37. ncbi Multiple folding pathways for the P4-P6 RNA domain
    S K Silverman
    Department of Chemistry and Biochemistry and Howard Hughes Medical Institute, University of Colorado at Boulder, Boulder, Colorado 80309, USA
    Biochemistry 39:12465-75. 2000
    ..The fast kinetic phase reflects folding that is facilitated by these interactions, whereas the slow kinetics are observed when these interactions are disrupted at lower ionic strength and higher temperature...
  38. ncbi DNA damage in T- and B-lymphocytes and granulocytes in emission inspection and incineration workers exposed to polycyclic aromatic hydrocarbons
    Donggeun Sul
    Department of Preventive Medicine, College of Medicine and Institute for Environmental Health, Medical Science Research Center, Korea University, Seoul, South Korea
    Mutat Res 538:109-19. 2003
    ..A comparison of DNA damage in three groups showed that B-lymphocytes are useful target in the biomonitoring of human exposure...
  39. ncbi Anionic fullerenes, calixarenes, coronenes, and pyrenes as activators of oligo/polyarginines in model membranes and live cells
    Florent Perret
    Department of Organic Chemistry, University of Geneva, Geneva, Switzerland, Institute for Chemical Research, Kyoto University and PRESTO, JST, Kyoto, Japan
    J Am Chem Soc 127:1114-5. 2005
    ..Applied to HeLa cells, pyrenebutyrate is shown to significantly increase the uptake of a fluorescently labeled octaarginine in a concentration-dependent manner...
  40. ncbi Elevated levels of urinary 8-hydroxy-2 -deoxyguanosine, lymphocytic micronuclei, and serum glutathione S-transferase in workers exposed to coke oven emissions
    Ai-Lin Liu
    Department of Occupational and Environmental Health and Ministry of Education Key Lab for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
    Environ Health Perspect 114:673-7. 2006
    ..The consequences of the changes in these biomarkers, such as risk of cancer, warrant further investigations...
  41. ncbi An early transition state for folding of the P4-P6 RNA domain
    S K Silverman
    Department of Chemistry and Biochemistry, University of Colorado at Boulder, 80309 0215, USA
    RNA 7:161-6. 2001
    ..Our kinetic data are some of the first to provide quantitative values for an activation barrier and location of a transition state for tertiary folding of an RNA domain...
  42. ncbi Benchmark guideline for urinary 1-hydroxypyrene as biomarker of occupational exposure to polycyclic aromatic hydrocarbons
    F J Jongeneelen
    IndusTox Consult, PO Box 31070, NL 6503 CB, Nijmegen, The Netherlands
    Ann Occup Hyg 45:3-13. 2001
    ..3 micromol mol(-1) creatinine and 4.9 micromol mol(-1) creatinine, respectively, in these two industries. These latter values present the third level of the benchmark guideline...
  43. ncbi Urinary 1-hydroxypyrene and polycyclic aromatic hydrocarbon exposure among asphalt paving workers
    M D McClean
    Harvard School of Public Health, Boston, MA 02115, USA
    Ann Occup Hyg 48:565-78. 2004
    ....
  44. ncbi A pyrene-labeled G-quadruplex oligonucleotide as a fluorescent probe for potassium ion detection in biological applications
    Satoru Nagatoishi
    Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka 812-858, Japan
    Angew Chem Int Ed Engl 44:5067-70. 2005
  45. ncbi Optimization of excimer-forming two-probe nucleic acid hybridization method with pyrene as a fluorophore
    M Masuko
    Tsukuba Research Laboratory, Hamamatsu Photonics K K, Tokodai, Tsukuba 300 2635, Japan
    Nucleic Acids Res 26:5409-16. 1998
    ..two-probe nucleic acid hybridization (ETPH) method, is based on specific excimer formation between two pyrenes attached at the neighboring terminals of two sequential probe oligonucleotides complementary to a single target...
  46. ncbi Effects of genetic polymorphisms in metabolic enzymes on the relationships between 8-hydroxydeoxyguanosine levels in human leukocytes and urinary 1-hydroxypyrene and 2-naphthol concentrations
    Yong Dae Kim
    Department of Preventive Medicine, College of Medicine, Chungbuk National University, South Korea
    J Occup Health 45:160-7. 2003
    ..This relationship is affected by genetic polymorphisms in PAH metabolic enzymes...
  47. ncbi Pyrene-labeled oligodeoxynucleotide probe for detecting base insertion by excimer fluorescence emission
    Akimitsu Okamoto
    Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University and SORST, Japan Science and Technology Corporation, Kyoto 615-8510, Japan
    J Am Chem Soc 126:8364-5. 2004
    ..This method is useful for the determination of the presence/absence of insertion polymorphisms located at a specific site on the target DNA...
  48. ncbi Urinary 1-hydroxypyrene and t,t-muconic acid as biomarkers of exposure to environmental pollutants in two areas in Italy (EPIC-Florence and Ragusa)
    Calogero Saieva
    Molecular and Nutritional Epidemiology Unit, CSPO, Scientific Institute of Tuscany, Florence, Italy
    Tumori 89:679-86. 2003
    ..CONCLUSIONS: These two urinary metabolites are strongly related to tobacco smoke and do not appear to represent reliable biomarkers of exposure to environmental pollutants in the general population...
  49. ncbi Unambiguous detection of target DNAs by excimer-monomer switching molecular beacons
    Kazuhisa Fujimoto
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    J Org Chem 69:3271-5. 2004
    ..Advantages of the excimer-monomer switching molecular beacons were discussed in comparison with conventional ones...
  50. ncbi Pyrene-labeled base-discriminating fluorescent DNA probes for homogeneous SNP typing
    Akimitsu Okamoto
    Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University and SORST, Japan Science and Technology Corporation, Kyoto 615-8510, Japan
    J Am Chem Soc 126:4820-7. 2004
    ..Py)U- and (Py)C-containing oligodeoxynucleotides acted as effective reporter probes for homogeneous SNP typing of DNA samples containing c-Ha-ras and BRCA2 SNP sites...
  51. ncbi Locked nucleic acids and intercalating nucleic acids in the design of easily denaturing nucleic acids: thermal stability studies
    Vyacheslav V Filichev
    Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark
    Chembiochem 5:1673-9. 2004
    ..When two INA monomers were inserted into the stem of the LNA hairpin, the same experiment resulted in a significant hyperchromicity comparable with the one obtained for the corresponding DNA/DNA duplex...
  52. ncbi Exposure to genotoxins present in ambient air in Bangkok, Thailand--particle associated polycyclic aromatic hydrocarbons and biomarkers
    Mathuros Ruchirawa
    Laboratory of Environmental Toxicology, Chulabhorn Research Institute, Bangkok, Thailand
    Sci Total Environ 287:121-32. 2002
    ..However, for people who spend their working day in offices, the exposure is similar to people living in other metropolitan areas...
  53. ncbi Detection of acceptor sites for antisense oligonucleotides on native folded RNA by fluorescence spectroscopy
    Atsushi Mahara
    Department of Polymer Science and Engineering, Kyoto Institute of Technology, Matsugasaki, Kyoto 606 8585, Japan
    Bioorg Med Chem 11:2783-90. 2003
    ..These results indicated that the site targeted by OMUpy-8 was exposed to regulatory molecules, and suggest that the method presented here is useful to design antisense molecules...
  54. ncbi DNA strand breaks, oxidative damage, and 1-OH pyrene in roofers with coal-tar pitch dust and/or asphalt fume exposure
    M Toraason
    National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA
    Int Arch Occup Environ Health 74:396-404. 2001
    ..The increase in urinary 8OHdG coupled with the decrease in leukocyte 8-OHdG/dG, suggests that coal-tar exposure induces protective or repair mechanisms that result in reduced levels of steady-state oxidative-DNA damage...
  55. ncbi Physicochemical characterization of coke-plant soil for the assessment of polycyclic aromatic hydrocarbon availability and the feasibility of phytoremediation
    Sungwoo Ahn
    Department of Civil and Environmental Engineering, Stanford University, Stanford, California 94305-4020, USA
    Environ Toxicol Chem 24:2185-95. 2005
    ..The observed low bioavailability of PAHs probably inhibited PAH phytoremediation, as diffusion-limited mass transfer would limit the release of PAHs to the aqueous phase...
  56. ncbi Two fish bile reference materials certified for PAH metabolites
    Freek Ariese
    Department of Analytical Chemistry and Applied Spectroscopy and Institute for Environmental Studies, Vrije Universiteit Amsterdam, De Boelelaan 1087, NL 1081 HV, Amsterdam, The Netherlands
    J Environ Monit 7:869-76. 2005
    ..The major findings from earlier feasibility studies and recommendations for the optimal use of the reference materials are also included...
  57. ncbi Site contamination health risk assessment case study involving tenant relocation from a former gasworks site
    Len Turczynowicz
    Department of Health, Environmental Health Service, Adelaide, South Australia, Australia
    J Toxicol Environ Health A 70:1638-53. 2007
    ..Data indicated a low health risk associated with tenancy on the site. This report presents details of the health risk assessment process undertaken and discusses vindicative reasons for tenant relocation...
  58. ncbi The distribution and sources of polycyclic aromatic hydrocarbons in surface sediments along the Egyptian Mediterranean coast
    Ahmed El Nemr
    Environmental Division, National Institute of Oceanography and Fisheries, Kayet Bay, Alexandria, Egypt
    Environ Monit Assess 124:343-59. 2007
    ..Interferences of rather petrogenic and pyrolytic PAH contaminations were noticed in the harbors due to petroleum products deliveries and fuel combustion emissions from the ships staying alongside the quays...
  59. ncbi Differential responses of eubacterial, Mycobacterium, and Sphingomonas communities in polycyclic aromatic hydrocarbon (PAH)-contaminated soil to artificially induced changes in PAH profile
    Maarten Uyttebroek
    Division of Soil and Water Management, Catholic University of Leuven, Kasteelpark Arenberg 20, B 3001 Leuven, Belgium
    J Environ Qual 36:1403-11. 2007
    ....
  60. ncbi 1-Hydroxypyrene concentrations in first morning voids and 24-h composite urine: intra- and inter-individual comparisons
    In Kyu Han
    School of Public Health, Department of Environmental and Occupational Health, University of Medicine and Dentistry of New Jersey, 683 Hoes Lane West, Piscataway, New Jersey 08854, USA
    J Expo Sci Environ Epidemiol 18:477-85. 2008
    ..Creatinine adjustments did not significantly improve overall correlations between first morning void and 24-h measurements, but increased total variances for 24-h urines explained by first morning urines in coke workers...
  61. ncbi Urinary hydroxylated metabolites of polycyclic aromatic hydrocarbons as biomarkers of exposure in asphalt workers
    M Buratti
    Department of Occupational and Environmental Health, University of Milan and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via S Barnaba, Milan, Italy
    Biomarkers 12:221-39. 2007
    ..Fumes and vapours released during laying of hot asphalt mix have been recognised as a major source of exposure for asphalt workers...
  62. ncbi Occupational exposure to polycyclic aromatic hydrocarbons in German industries: association between exogenous exposure and urinary metabolites and its modulation by enzyme polymorphisms
    Hans Peter Rihs
    Berufsgenossenschaftliches Forschungsinstitut fur Arbeitsmedizin BGFA, Ruhr University of Bochum, Buerkle de la Camp Platz 1, 44789 Bochum, Germany
    Toxicol Lett 157:241-55. 2005
    ..001). OHPhe turned out to be also a suitable biomarker of occupational PAH exposure. The association with ambient PAH exposure and the influence of polymorphisms was more pronounced for OHPhe...
  63. ncbi Uptake of selected PAHs from contaminated soils by rice seedlings (Oryza sativa) and influence of rhizosphere on PAH distribution
    Yu Hong Su
    Chemistry Department, Xinjiang University, Urumqi 830046, China
    Environ Pollut 155:359-65. 2008
    ..24 and 14%, respectively, based on PYR concentrations in rhizosphere and non-rhizosphere soils, the biomass of rice roots, and the dry soil weight...
  64. ncbi Cyclodextrin enhanced biodegradation of polycyclic aromatic hydrocarbons and phenols in contaminated soil slurries
    Ian J Allan
    School of Environmental Sciences, University of East Anglia, NR4 7TJ Anglia, United Kingdom
    Environ Sci Technol 41:5498-504. 2007
    ..05) more available for biodegradation...
  65. ncbi Spatial distribution and sources of polycyclic aromatic hydrocarbons (PAHs) in soils from typical oil-sewage irrigation area, Northeast China
    Xiaojun Li
    Institute of Applied Ecology, Chinese Academy of Sciences, P O Box 417, Wenhua Road 72, Shenyang 110016, Peoples Republic of China
    Environ Monit Assess 143:257-65. 2008
    ....
  66. ncbi Uptake of polycyclic aromatic hydrocarbons by Trifolium pretense L. from water in the presence of a nonionic surfactant
    Yanzheng Gao
    College of Resource and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China
    Chemosphere 72:636-43. 2008
    ..Results from this study show promises for the potential efficacy of enhanced phytoremediation in PAH contaminated sites using surfactant amendment...
  67. ncbi [Environmental and biological monitoring of exposure to polycyclic aromatic hydrocarbons in workers of an electric steel foundry]
    E Bergamaschi
    Dipartimento di Clinica Medica, Nefrologia e Scienze della Prevenzione, Sezione di Medicina del Lavoro e Tossicologia Industriale, Universita degli Studi di Parma
    Med Lav 96:390-402. 2005
    ..To assess and classify exposure to Polycyclic Aromatic Hydrocarbons (PAHs) in some specific working areas of a steel foundry operating with a continuous casting process and evaluate biomonitoring data in different job tasks...
  68. ncbi The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers
    Bo Chen
    Department of Occupational Health and Toxicology, School of Public Health, Fudan University, Shanghai, 200032, PR China
    Sci Total Environ 381:38-46. 2007
    ..No influence was found in the association between urinary 1-OHP and other genetic polymorphisms such as CYP1A1, CYP1A2, CYP1B1, CYP2E1, EPHX1, EPHX2 in this population...
  69. ncbi External and internal exposure to polycyclic aromatic hydrocarbons (PAH) among workers in the production of fire-proof materials - proposal of a biological monitoring guidance value
    Ralf Preuss
    University of Erlangen-Nuremberg, Institute and Outpatient Clinic of Occupational, Social- and Environmental Medicine, Erlangen, Germany
    Int J Hyg Environ Health 209:575-80. 2006
    ..The following BMGVs for the non-smokers of this branch of industry are proposed: for 1-hydroxypyrene 18microg/g creatinine and for the sum of hydroxyphenanthrenes 77microg/g creatinine in urine measured at the end of the shift...
  70. ncbi [Effects of co-substrates on biodegradation of pyrene by ten bacterial strains]
    Dan Su
    Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China
    Ying Yong Sheng Tai Xue Bao 18:636-40. 2007
    ..8%. For SB04 and SB09, the biodegradation rate of PYR had no significant difference between MS1 and MS2, but for other strains, the stimulation effect of phenanthrene on PYR degradation was higher than that of glucose...
  71. ncbi Simultaneous determination of urinary hydroxylated metabolites of naphthalene, fluorene, phenanthrene, fluoranthene and pyrene as multiple biomarkers of exposure to polycyclic aromatic hydrocarbons
    Thaneeya Chetiyanukornkul
    Environmental Science Program, Faculty of Science, Chiang Mai University, Chiang Mai, 50200, Thailand
    Anal Bioanal Chem 386:712-8. 2006
    ..The results showed higher urinary concentrations of OHPAHs in rural villagers, consistent with higher respiratory exposure to PAHs...
  72. ncbi Partitioning and source diagnostics of polycyclic aromatic hydrocarbons in rivers in Tianjin, China
    Z Shi
    College of Environmental Sciences, Peking University, Beijing 100871, P R China
    Environ Pollut 146:492-500. 2007
    ..Coal combustion was identified to be a long-term and prevailing contamination source for sediment, while sewage/wastewater source could reasonably explain a short-term PAHs contamination of SPM...
  73. ncbi Identification of polycyclic aromatic hydrocarbons (PAHs) in suspended particulate matter by synchronous fluorescence spectroscopic technique
    Homdutt Sharma
    Department of Physics, Jamia Millia Islamia, Jamia Nagar, New Delhi 110 025, India
    Spectrochim Acta A Mol Biomol Spectrosc 68:43-9. 2007
    ..This is in agreement with our earlier work for determination of these PAHs using gas chromatography (GC). The seasonal variation of the PAHs was found to be maximum in winter and minimum during the monsoon...
  74. ncbi Selection and identification of bacteria isolated from waste crude oil with polycyclic aromatic hydrocarbons removal capacities
    F L Toledo
    Group of Environmental Microbiology, Department of Microbiology, Institute of Water Research, University of Granada, , Edificio Fray Luis de Granada, 18071 Granada, Spain
    Syst Appl Microbiol 29:244-52. 2006
    ..Finally, the capacity of certain strains to emulsify octane, xilene, toluene, mineral oil and crude oil, and its ability to remove hydrocarbons, look promising for its application in bioremediation technologies...
  75. ncbi Further validation of the HPCD-technique for the evaluation of PAH microbial availability in soil
    Kieron J Doick
    Department of Environmental Science, Institute of Environmental and Natural Science, Lancaster University, Bailrigg, Lancaster, LA1 4YQ, UK
    Environ Pollut 144:345-54. 2006
    ..Overall, a single HPCD-extraction technique proved accurate and reproducible for the estimation of PAH bioavailability from soil...
  76. ncbi Direct and indirect photolysis of polycyclic aromatic hydrocarbons in nitrate-rich surface waters
    Laura E Jacobs
    Environmental Science Graduate Program, The Ohio State University, Columbus, Ohio 43210, USA
    Environ Toxicol Chem 27:1643-8. 2008
    ..Overall photoreaction rates decreased for the lower-molecular-weight PAHs, because the fastest naphthalene photolytic rate was roughly two orders of magnitude slower than that of pyrene...
  77. ncbi Distribution of polycyclic aromatic hydrocarbons in thirty typical soil profiles in the Yangtze River Delta region, east China
    L F Ping
    Soil and Environment Bioremediation Research Center, State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences, Nanjing, China
    Environ Pollut 147:358-65. 2007
    ..Phenanthrene was found in soils below a depth of 100 cm in half of the sampling sites, but the detectable ratio of benzo(a)pyrene decreased sharply from 100% in topsoil to 0 in the 4th horizon...
  78. ncbi Impact of chemical oxidation on soil quality
    Catherine Sirguey
    Laboratoire Sols et Environnement UMR 1120, Nancy Université INPL INRA, 2 Avenue de la Foret de Haye, BP 172, Vandoeuvre les Nancy Cedex, France
    Chemosphere 72:282-9. 2008
    ..Plant growth was negatively affected by permanganate, related to lower soil permeability and aeration. Both treatments had an effect on soil properties but Fenton oxidation appeared to be more compatible with revegetation...
  79. ncbi Increased urinary excretion of 8-hydroxydeoxyguanosine in engine room personnel exposed to polycyclic aromatic hydrocarbons
    R Nilsson
    Department of Occupational Medicine, Goteborg University, St Sigfridsgatan 85, SE 41266 Göteborg, Sweden
    Occup Environ Med 61:692-6. 2004
    ..Several PAH are known carcinogens and mutagens...
  80. ncbi Characterization of cultures enriched from acidic polycyclic aromatic hydrocarbon-contaminated soil for growth on pyrene at low pH
    Maarten Uyttebroek
    Division Soil and Water Management, Catholic University of Leuven, Kasteelpark Arenberg 20, B 3001 Leuven, Belgium
    Appl Environ Microbiol 73:3159-64. 2007
    ..Our data indicate that a slow-growing Mycobacterium species is involved in PAH degradation in that culture and show that bacteria able to degrade high-molecular-weight PAHs at low pH are present in acidic PAH-contaminated soil...
  81. ncbi Assessment of contaminated sediments with an indoor freshwater/sediment microcosm assay
    Gaëlle Triffault-Bouchet
    Laboratoire des Sciences de l Environnement, Ecole Nationale des Travaux Publics de I Etat, Rue Maurice Audin, 69518 Vaulx en Velin Cedex, France
    Environ Toxicol Chem 24:2243-53. 2005
    ..Sediments A, B, C, and E should not be deposited in gravel quarries, and new, more sensitive endpoint measurements should be developed...
  82. ncbi Evaluation of biological monitoring markers using genomic and proteomic analysis for automobile emission inspectors and waste incinerating workers exposed to polycyclic aromatic hydrocarbons or 2,3,7,8,-tetracholrodedibenzo-p-dioxins
    Meyoung Kon Kim
    Department of Biochemistry and Molecular Biology, School of Medicine, Seoul 136-705, Korea
    Exp Mol Med 36:396-410. 2004
    ..Several proteins, such as transthyrethin, sarcolectin and haptoglobin, that were highly up- or down-regulated, could serve as biological monitoring markers for future study...
  83. ncbi [Bioremediation of PAHs contaminated soil using bio-slurry reactor process]
    Peijun Li
    Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016
    Ying Yong Sheng Tai Xue Bao 13:327-30. 2002
    ..In this research, the optimized parameters were operating temperature as 20-30 degrees C, ratio between water and soil as 2:1, airflow as 8 L.h-1.L-1, and the inoculating amount as 50 g.kg-1...
  84. ncbi Synchronous fluorescence spectrometry of 1-hydroxypyrene: a rapid screening method for identification of PAH exposure in tissue from marine polychaetes
    Anders M B Giessing
    Darling Marine Center, University of Maine, Walpole, ME 04573, USA
    Mar Environ Res 56:599-615. 2003
    ..I. and Arenicola marina appear to utilize predominantly sulfate and/or glucoside conjugation. The usefulness of 1-hydroxypyrene as a biomarker for PAH exposure in deposit-feeding invertebrates is discussed...
  85. ncbi "Humic coverage index" as a determining factor governing strain-specific hydrocarbon availability to contaminant-degrading bacteria in soils
    Bill W Bogan
    Gas Technology Institute, 1700 South Mount Prospect Road, Des Plaines, Illinois 60018, USA
    Environ Sci Technol 37:5168-74. 2003
    ....
  86. ncbi 1-Hydroxypyrene as a biomarker for fish exposure to polycyclic aromatic hydrocarbons
    T Hosnedl
    Department of Food Chemistry and Analysis, Institute of Chemical Technology, , 166 28 Prague 6, Czech Republic
    Bull Environ Contam Toxicol 71:465-72. 2003
  87. ncbi Multiple biomarkers study in painters in a shipyard in Korea
    Kyoung Ho Lee
    Department of Preventive Medicine, Institute of Environmental Medicine, Seoul National University College of Medicine, SNUMRC, 28 Yongon Dong, Chongno Gu, Seoul 110 799, South Korea
    Mutat Res 540:89-98. 2003
    ..These results suggest that painters in the shipyard were exposed to significant amounts of PAHs and possibly to other genotoxic aromatic compounds, and that urinary 1-OHPG may be a potential biomarker of PAH exposure in this population...
  88. ncbi Screening pyrene metabolites in the hemolymph of dungeness crabs (Cancer magister) with synchronous fluorescence spectrometry: method development and application
    Curtis V Eickhoff
    Department of Biological Sciences, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia V5A 1S6, Canada
    Environ Toxicol Chem 22:59-66. 2003
    ..Pyrene-associated fluorescent responses of the hemolymph were found to correlate positively with the concentration of total PAHs in the hepatopancreas (r = 0.39, p < 0.05)...
  89. ncbi Monitoring human occupational and environmental exposures to polycyclic aromatic compounds
    Henk C A Brandt
    Z. Jansestraat 46 II, 1097 CN, Amsterdam, The Netherlands
    Ann Occup Hyg 47:349-78. 2003
    ..Because of their strong association with cancer, chromosome aberrations are considered suitable indicators of increased cancer risk arising from exposure to PACs...
  90. ncbi Pyrene biotransformation products as biomarkers of polycyclic aromatic hydrocarbon exposure in terrestrial Isopoda: concentration-response relationship, and field study in a contaminated forest
    Gerard J Stroomberg
    Institute for Environmental Studies, Vrije Universiteit, De Boelelaan 1087, 1081 HV, Amsterdam, The Netherlands
    Environ Toxicol Chem 22:224-31. 2003
    ..As pyrene is one of the most predominant PAHs, analysis of its metabolites provides a good tool for environmental risk assessment of ecosystems with regard to PAH exposure, bioavailability, and biotransformation...
  91. ncbi Quantification of monohydroxy-PAH metabolites in urine by solid-phase extraction with isotope dilution-GC-MS
    Christopher J Smith
    Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Anal Bioanal Chem 372:216-20. 2002
    ..Method detection limits ranged from 2 ng L(-1) for 1-hydroxypyrene to 43.5 ng L(-1) for 1-hydroxynaphthalene. Using quality control charts from two urine pools, the method can be readily applied to biomonitoring PAH exposure...
  92. ncbi Detection of 1-hydroxypyrene in urine by direct fluorometric analysis on a solid sorbing phase. Validation and application of the method to biological monitoring of PAH-exposed persons
    Michel Lamotte
    Laboratoire de Physico Toxico Chimie, UMR CNRS 5472, Universite Bordeaux 1, F33405, Talence, France
    Anal Bioanal Chem 376:816-21. 2003
    ..Thus, the method appears to be an alternative to the usual method based on HPLC. Moreover it presents some advantages, being simple to operate and requiring relatively low-cost instruments...
  93. ncbi Simultaneous analysis of naphthols, phenanthrols, and 1-hydroxypyrene in urine as biomarkers of polycyclic aromatic hydrocarbon exposure: intraindividual variance in the urinary metabolite excretion profiles caused by intervention with beta-naphthoflavone
    Eivor Elovaara
    Laboratory of Toxicokinetics and Metabolism, Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, 00250, Helsinki, Finland
    Arch Toxicol 77:183-93. 2003
    ..This intervention study clarifies intraindividual variation in PAH metabolism and provides useful information for the development of new methods applicable in the biomonitoring of PAH exposure in humans...
  94. ncbi Bioaugmentation of tar-contaminated soils under field conditions using Pleurotus ostreatus refuse from commercial mushroom production
    Helle Hestbjerg
    Danish Institute of Agricultural Sciences, Department of Crop Physiology and Soil Science, Research Centre Foulum, PO Box 50, DK-8830 Tjele, Denmark
    Environ Toxicol Chem 22:692-8. 2003
    ..Reasons for the difference in performance of P. ostreatus in the two soils are discussed in terms of soil histories and bioavailability. The use of P. ostreatus refuse holds promising potential for bioremediation purposes...
  95. ncbi Urinary 1-hydroxypyrene as an indicator for assessing the exposures of booth attendants of a highway toll station to polycyclic aromatic hydrocarbons
    Perng Jy Tsai
    Department of Environmental and Occupational Health, Medical College, National Cheng Kung University, 138 Sheng Li Road, Tainan 704, Taiwan
    Environ Sci Technol 38:56-61. 2004
    ....
  96. ncbi Differential gene expression in mummichogs (Fundulus heteroclitus) following treatment with pyrene: comparison to a creosote contaminated site
    Jonathan A Roling
    University of Texas at El Paso, Biological Sciences, El Paso, TX 79968, USA
    Mar Environ Res 57:377-95. 2004
    ..Ultimately, we anticipate that the use of multiple biomarkers of PAH exposure will provide useful information on the potential effects of toxicants...
  97. ncbi A non-destructive assessment of the exposure of crabs to PAH using ELISA analyses of their urine and haemolymph
    G Fillmann
    Fundaçãdo Universidade Federal do Rio Grande, Depto de Oceanografia, Brazil
    Mar Environ Res 54:823-8. 2002
    ..Again, a good correlation was recorded between the ELISA and spectrofluorimetric analysis (r2 = 0.83). In this instance, difficulties were experienced with haemolymph analyses owing to a lack of sensitivity...
  98. ncbi Pyrene biotransformation and kinetics in the hepatopancreas of the isopod Porcellio scaber
    G J Stroomberg
    Institute for Environmental Studies, Vrije Universiteit, De Boelelaan 1087, 1081 HV, Amsterdam, Netherlands
    Arch Environ Contam Toxicol 47:324-31. 2004
    ....
  99. ncbi BIOMarkers for occupational diesel exhaust exposure monitoring (BIOMODEM)--a study in underground mining
    P T J Scheepers
    Department of Epidemiology and Biostatistics, University Medical Centre St Radboud, PO Box 9101, NL 6500 HB Nijmegen, The Netherlands
    Toxicol Lett 134:305-17. 2002
    ..The study indicated that smoking, diet and residential indoor air pollution are important non-occupational factors to consider when interpreting biomonitoring results...
  100. ncbi Determination of exposure to polycyclic aromatic hydrocarbons in some work groups in Turkey by measurement of 1-hydroxypyrene levels in urine
    I Ates
    Department of Toxicology, Faculty of Pharmacy, Ankara University, 06100, Tandogan, Ankara, Turkey
    Bull Environ Contam Toxicol 73:242-8. 2004
  101. ncbi Evaluation of chemical pretreatment of contaminated soil for improved PAH bioremediation
    Reetta Piskonen
    VTT Biotechnology, PO Box 1500, 02044, Espoo, Finland
    Appl Microbiol Biotechnol 65:627-34. 2004
    ..The efficiency of the Fenton oxidation may decrease when surfactants are added simultaneously with Fenton's reagent to contaminated soil...

Research Grants68

  1. Interventions for Tobacco Dependent Adolescents
    Dorothy Hatsukami; Fiscal Year: 2005
    ....
  2. BIOLOGICAL EFFECTS OF DNA ADDUCTS FORMED BY NITROPYRENES
    ASHIS BASU; Fiscal Year: 2002
    ..objective of this research is to investigate the mechanism of mutagenesis and DNA repair induced by the nitrated pyrenes that are known environmental pollutants and are suspected to pose threats to human health...
  3. BIOLOGICAL EFFECTS OF DNA ADDUCTS FORMED BY NITROPYRENES
    ASHIS BASU; Fiscal Year: 2006
    ..objective of this research is to investigate the mechanism of mutagenesis and DNA repair induced by the nitrated pyrenes that are known environmental pollutants and are suspected to pose threats to human health...
  4. INDEPENDENT SCIENTIST AWARD (NIEHS)
    ASHIS BASU; Fiscal Year: 2002
    ..of this current research is to investigate the mechanisms of mutagenesis and DNA repair induced by the nitrated pyrenes. To accomplish this goal, his laboratory has used the tools of organic synthesis and recombinant DNA technology ..
  5. REACTIVE INTERMEDIATES OF CARCINOGENESIS OF PAHS
    KENNETH LAALI; Fiscal Year: 2004
    ..DNA binding and mammalian cell mutagenicity studies on the substituted and derivatized-PAHs proposed for stable ion work will enhance the available literature data on structure/reactivity relationships. ..
  6. Allosteric DNAzyme sensors for practical detection of mycotoxins
    SCOTT SILVERMAN; Fiscal Year: 2007
    ..Improved sensors for detecting mycotoxins and thereby revealing the presence of fungi will allow proper remedial actions to be taken. ..
  7. Development and validation of a woodsmoke biomarker in urine
    Christopher Simpson; Fiscal Year: 2007
    ....
  8. A Request for support of 25th SPRSM Meeting
    James Wang; Fiscal Year: 2006
    ....
  9. Perfluorooctane sulfonate (PFOS) Affects Immunity through PPAR-alpha.
    Margie Peden Adams; Fiscal Year: 2007
    ..In Experiment B mice will not be immunized. The unimmunized and immunized experiments will be conducted to control for possible differences in response related to lymphocyte activation from the immunization. ..
  10. Evaluation of urinary 1-nitropyrene metabolities as a biomarker for exposure to d
    Christopher Simpson; Fiscal Year: 2007
    ....
  11. TOBACCO EXPOSURE REDUCTION
    Dorothy Hatsukami; Fiscal Year: 2007
    ..The results of research from this TTURC will provide the scientific basis for urgent policy, public education, and regulatory efforts to reduce tobacco harm. ..
  12. Innovative Interventions for Smoking Cessation
    Dorothy Hatsukami; Fiscal Year: 2009
    ..The results of this study will provide useful information on directions to pursue to improve our pharmacotherapies and behavioral treatments and to better understand the various aspects of addiction. ..
  13. Factors influencing regulation of the dynamics of the actin filament pointed end
    Alla Kostyukova; Fiscal Year: 2009
    ..The information obtained in this study will help us to understand the formation of the capping complex at the pointed end and its function in regulating dynamics of the actin filament in cells and tissues. ..
  14. Evaluation of Oral Tobacco as a Harm Reduction Method for Smokers
    Dorothy Hatsukami; Fiscal Year: 2009
    ..The results from these studies will help determine the effects and feasibility of using oral tobacco products as both a cessation aid and a method to reduce individual health risk in cigarette smokers. ..
  15. Factors influencing regulation of the dynamics of the actin filament pointed end
    Alla S Kostyukova; Fiscal Year: 2010
    ..The information obtained in this study will help us to understand the formation of the capping complex at the pointed end and its function in regulating dynamics of the actin filament in cells and tissues. ..
  16. Evaluation of Oral Tobacco as a Harm Reduction Method for Smokers
    Dorothy K Hatsukami; Fiscal Year: 2010
    ..The results from these studies will help determine the effects and feasibility of using oral tobacco products as both a cessation aid and a method to reduce individual health risk in cigarette smokers. ..
  17. Novel Determinants and Measures of Smokeless Tobacco Use
    Dorothy K Hatsukami; Fiscal Year: 2010
    ..This study would demonstrate the feasibility and impact of switching ST users to less toxic ST products. Together, these studies will help to guide important policy decisions to reduce the toll of tobacco-related disease. ..
  18. Quantifying Biosynthesized Porphyrins and Complexes
    MARK SCHLAUTMAN; Fiscal Year: 2004
    ..The CL detection systems developed for ion-pair HPLC in this project will ultimately find use as powerful new detection systems for micro-chip, nano-chip, and microarray applications. ..
  19. A Multidisciplinary Study of Mechanisms for Tendinitis
    James Wang; Fiscal Year: 2005
    ..The findings from this study will also be useful in helping design experiments to study other repetitive motion disorders (e.g., carpal tunnel syndrome). ..
  20. STAR POLYMER UNIMOLECULAR MICELLES FOR DRUG DELIVERY
    Fei Wang; Fiscal Year: 2004
    ..abstract_text> ..
  21. TIMING OF SMOKING INTERVENTION IN ALCOHOL TREATMENT
    ANNE JOSEPH; Fiscal Year: 2001
    ....
  22. Semiconductor Nanocrystals for Biomedical Imaging
    Fei Wang; Fiscal Year: 2005
    ..Both types of encapsulated nanoparticle probes will be used to transfect cultured mammalian cells in order to assess QD luminescence in a physiological milieu. ..
  23. BRANCHED COPOLYMER AS PEPTIDE DRUG DELIVERY SYSTEM
    Fei Wang; Fiscal Year: 2006
    ..New drug delivery systems have had an impact on nearly every branch of medicine. Controlled drug delivery is a $20 billion industry and rising rapidly...