Genomes and Genes
Summary: Two-ring crystalline hydrocarbons isolated from coal tar. They are used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, preservatives, and, formerly, as topical antiseptics.
Publications298 found, 100 shown here
- Myosin-II-dependent localization and dynamics of F-actin during cytokinesisKausalya Murthy
Department of Biology and Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, 01003, USA
Curr Biol 15:724-31. 2005..The mechanism(s) that contribute to the spatially and temporally regulated assembly and disassembly of the CR at the cell equator are poorly understood...
- Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysisGeoffrey A Block
Denver Nephrologists, Denver, USA
N Engl J Med 350:1516-25. 2004..We report the results of two identical randomized, double-blind, placebo-controlled trials evaluating the safety and effectiveness of the calcimimetic agent cinacalcet hydrochloride...
- Combined therapy with cinacalcet and low doses of vitamin D sterols in patients with moderate to severe secondary hyperparathyroidismGeoffrey A Block
Denver Nephrologists, Denver, CO 80230, USA
Nephrol Dial Transplant 23:2311-8. 2008....
- Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymesBirgit Heltweg
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Cancer Res 66:4368-77. 2006..Cambinol was well tolerated in mice and inhibited growth of Burkitt lymphoma xenografts. Inhibitors of NAD-dependent deacetylases may constitute novel anticancer agents...
- Paricalcitol versus cinacalcet plus low-dose vitamin D therapy for the treatment of secondary hyperparathyroidism in patients receiving haemodialysis: results of the IMPACT SHPT studyMarkus Ketteler
Division of Nephrology, Klinikum Coburg, Coburg, Germany
Nephrol Dial Transplant 27:3270-8. 2012....
- The ADVANCE study: a randomized study to evaluate the effects of cinacalcet plus low-dose vitamin D on vascular calcification in patients on hemodialysisPaolo Raggi
Division of Cardiology, Emory University, Atlanta, GA, USA
Nephrol Dial Transplant 26:1327-39. 2011....
- Inhibition of interneuron firing extends the spread of endocannabinoid signaling in the cerebellumAnatol C Kreitzer
Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
Neuron 34:787-96. 2002..Because interneurons can project over several hundred micrometers, this inhibition of firing allows cells to regulate synaptic inputs at distances well beyond the limits of endocannabinoid diffusion...
- Cinacalcet hydrochloride treatment significantly improves all-cause and cardiovascular survival in a large cohort of hemodialysis patientsGeoffrey A Block
Denver Nephrology Research Division, Denver, Colorado 80230, USA
Kidney Int 78:578-89. 2010..v. vitamin D. Definitive proof, however, of a survival advantage awaits the performance of randomized clinical trials...
- Effects of cinacalcet and concurrent low-dose vitamin D on FGF23 levels in ESRDJames B Wetmore
University of Kansas Medical Center, MS 3002, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
Clin J Am Soc Nephrol 5:110-6. 2010..The effects of various treatments for secondary hyperparathyroidism on FGF23 levels in ESRD have not been examined in a clinical trial...
- Synergistic effects of p38 mitogen-activated protein kinase inhibition with a corticosteroid in alveolar macrophages from patients with chronic obstructive pulmonary diseaseJ Armstrong
Medicines Evaluation Unit, National Institute for Health Research Translational Research Facility, University Hospital of South Manchester Foundation Trust, University of Manchester, Manchester, United Kingdom
J Pharmacol Exp Ther 338:732-40. 2011..Combining a p38 MAPK inhibitor with a corticosteroid synergistically enhances the anti-inflammatory effects on LPS-mediated cytokine production by alveolar macrophages from patients with COPD and controls...
- Cannabinoids prevent lipopolysaccharide-induced neurodegeneration in the rat substantia nigra in vivo through inhibition of microglial activation and NADPH oxidaseEun Sook Chung
Department of Biochemistry and Molecular Biology, School of Medicine Kyung Hee University, Seoul 130 701, Korea
Brain Res 1451:110-6. 2012..The present data suggest that cannabinoids may be beneficial for the treatment of neurodegenerative diseases, such as PD, that are associated with microglial activation...
- Bidirectional regulation of mu-opioid and CB1-cannabinoid receptor in rats self-administering heroin or WIN 55,212-2Liana Fattore
Institute of Neuroscience, National Research Council CNR, Section of Cagliari, Italy
Eur J Neurosci 25:2191-200. 2007....
- Effects of the calcimimetic cinacalcet HCl on cardiovascular disease, fracture, and health-related quality of life in secondary hyperparathyroidismJohn Cunningham
University College London, The Middlesex Hospital, London, UK
Kidney Int 68:1793-800. 2005..Cinacalcet, a calcimimetic that modulates the calcium-sensing receptor, reduces parathyroid hormone (PTH) secretion and lowers serum calcium and phosphorus concentrations in patients with end-stage renal disease (ESRD) and secondary HPT...
- Cinacalcet treatment and serum FGF23 levels in haemodialysis patients with secondary hyperparathyroidismMasahiro Koizumi
Division of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine, Isehara, Japan
Nephrol Dial Transplant 27:784-90. 2012..Cinacalcet hydrochloride is effective in treating SHPT, but little is known as to whether treatment with cinacalcet alters these levels and whether pretreatment FGF23 levels predict response to this therapy...
- Stable-isotope probing of the polycyclic aromatic hydrocarbon-degrading bacterial guild in a contaminated soilMaiysha D Jones
Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, CB 7431 Chapel Hill, NC 27599 7431, USA
Environ Microbiol 13:2623-32. 2011....
- Posttraining activation of CB1 cannabinoid receptors in the CA1 region of the dorsal hippocampus impairs object recognition long-term memoryJulia R Clarke
Centro de Memoria, Instituto de Pesquisas Biomédicas, Pontificia Universidade Catolica do Rio Grande do Sul, Av Ipiranga 6690, RS 90610 000 Porto Alegre, Brazil
Neurobiol Learn Mem 90:374-81. 2008..Our data indicate that activation of hippocampal CB1 receptors early after training hampers consolidation of object recognition memory...
- Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesisYannick Marchalant
Department of Psychology, The Ohio State University, Columbus, 43210, USA
Neurobiol Dis 34:300-7. 2009..Our results provide insight into the role of the endocannabinoid and vanilloid systems upon two different and detrimental aspects of normal and pathological aging, chronic neuroinflammation and decline in neurogenesis...
- Opposing actions of chronic Delta9-tetrahydrocannabinol and cannabinoid antagonists on hippocampal long-term potentiationAlexander F Hoffman
United States Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, Cellular Neurobiology Branch, Electrophysiology Research Unit, Baltimore, Maryland 21224, USA
Learn Mem 14:63-74. 2007..These data define consequences of repeated Delta(9)-THC exposure for synaptic plasticity in the hippocampus that may help explain memory impairments in humans following chronic marijuana use...
- Structure-activity relationships of the p38alpha MAP kinase inhibitor 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naph- thalen-1-yl]urea (BIRB 796)John Regan
Department of Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals, Research and Development Center, 900 Ridgebury Road, Ridgefield, Connecticut 06877, USA
J Med Chem 46:4676-86. 2003..Finally, we describe several compounds that potently inhibit TNF-alpha production when dosed orally in mice...
- Towards selective antagonists of T-type calcium channels: design, characterization and potential applications of NNC 55-0396Ming Li
Department of Pharmacology SL 83, Tulane University Health Science Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
Cardiovasc Drug Rev 23:173-96. 2005..We conclude that NNC 55-0396, by virtue of its modified structure, does not produce the metabolite that causes inhibition of L-type Ca2+ channel channels, thus rendering it more selective to T-type Ca2+ channels...
- Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activitiesChristopher M Jenkins
Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 279:48968-75. 2004....
- Inhibition of nitric oxide production in RAW264.7 macrophages by cannabinoids and palmitoylethanolamideR A Ross
Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, AB25 2ZD, Scotland, Aberdeen, UK
Eur J Pharmacol 401:121-30. 2000..In contrast, the inhibition by palmitoylethanolamide does not appear to be mediated by cannabinoid receptors...
- nag genes of Ralstonia (formerly Pseudomonas) sp. strain U2 encoding enzymes for gentisate catabolismN Y Zhou
School of Biological Sciences, University of Wales, Bangor, Gwynedd LL57 2UW, Wales, United Kingdom
J Bacteriol 183:700-8. 2001..NagJ is homologous to a glutathione S-transferase, and NagM and NagN are proteins homologous to each other and to other proteins of unknown function. Downstream of the operon is a partial sequence with homology to a transposase...
- CB1 cannabinoid receptors mediate anxiolytic effects: convergent genetic and pharmacological evidence with CB1-specific agentsJ Haller
Institute of Experimental Medicine, Budapest, Hungary
Behav Pharmacol 15:299-304. 2004..This suggests that agonists of the former, or antagonists of the latter, are promising new compounds in the pharmacotherapy of anxiety...
- Correlated species differences in the effects of cannabinoid ligands on anxiety and on GABAergic and glutamatergic synaptic transmissionJ Haller
Institute of Experimental Medicine, Department of Behavioral Neurobiology, 1450 Budapest, PO Box 67, Hungary
Eur J Neurosci 25:2445-56. 2007..We suggest that the anxiety-related effects of cannabinoids depend on the relative cannabinoid responsiveness of GABAergic and glutamatergic neurotransmission...
- Polybrominated diphenyl ethers, polychlorinated naphthalenes and polycyclic musks in human fat from Italy: comparison to polychlorinated biphenyls and organochlorine pesticidesAlessandra Schiavone
Department of Environmental Science G Sarfatti, University of Siena, Via P A Mattioli 4, I 53100 Siena, Italy
Environ Pollut 158:599-606. 2010Prior to this study, reports of occurrence of polycyclic musks and polychlorinated naphthalenes (PCNs) in human tissues from Italy were not available...
- Cinacalcet (KRN1493) effectively decreases the serum intact PTH level with favorable control of the serum phosphorus and calcium levels in Japanese dialysis patientsMasafumi Fukagawa
Division of Nephrology and Kidney Center, Kobe University School of Medicine, Chuo Ku, Kobe, Japan
Nephrol Dial Transplant 23:328-35. 2008..In this study, we examined the efficacy and safety of cinacalcet in Japanese patients on maintenance haemodialysis...
- Electronic polarizability as a predictor of biodegradation rates of dimethylnaphthalenes. an ab initio and density functional theory studyVito Librando
Research Centre for Analysis, Monitoring and Minimization Methods of Environmental Risk, c o Department of Chemistry, University of Catania, viale A Doria 8, 95125 Catania, Italy
Environ Sci Technol 41:1646-52. 2007..The present approach is potentially suitable for applications on PAHs with higher molecular weight...
- Reduced infarct size and accumulation of microglia in rats treated with WIN 55,212-2 after neonatal strokeD Fernández-López
Department of Neurology, Neonatal Brain Disorders Center, University of California San Francisco, 521 Parnassus Avenue, Room C 215, San Francisco, CA 94143 0663, USA
Neuroscience 207:307-15. 2012..Cumulatively, our results show that the cannabinoid agonist WIN protects against neonatal focal stroke in part due to inhibitory effects on microglia...
- Neuroprotective effect of WIN 55,212-2 pretreatment against focal cerebral ischemia through activation of extracellular signal-regulated kinases in ratsBo Hu
Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an 710032, Shaanxi Province, China
Eur J Pharmacol 645:102-7. 2010..These findings suggest that the neuroprotective effect of WIN 55,212-2 pretreatment against focal cerebral ischemia is through the activation of extracellular signal-regulated kinases in rats...
- Long-term treatment with cinacalcet and conventional therapy reduces parathyroid hyperplasia in severe secondary hyperparathyroidismMario Meola
Department of Internal Medicine, S Anna School of Advanced Studies, Nephrology and Dialysis Unit, University of Pisa, Italy
Nephrol Dial Transplant 24:982-9. 2009....
- Cannabinoid receptor agonist 13, a novel cannabinoid agonist: first in human pharmacokinetics and safetyAnne Gardin
Novartis Institutes for BioMedical Research, Basel, CH 4002, Switzerland
Drug Metab Dispos 37:827-33. 2009..Food intake increased CRA13 C(max) and AUC(0 - tz) by approximately 2-fold, whereas t(max) was unaffected...
- Cinacalcet effectively reduces parathyroid hormone secretion and gland volume regardless of pretreatment gland size in patients with secondary hyperparathyroidismHirotaka Komaba
Division of Nephrology and Kidney Center, Kobe University School of Medicine, Kobe, Japan
Clin J Am Soc Nephrol 5:2305-14. 2010..However, it has not been proven whether parathyroid gland size predicts response to therapy and whether cinacalcet is capable of inducing a reduction in parathyroid volume...
- Selective recognition of pyrimidine-pyrimidine DNA mismatches by distance-constrained macrocyclic bis-intercalatorsMatthias Bahr
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D 52056 Aachen, Germany
Nucleic Acids Res 36:5000-12. 2008..Altogether, our results demonstrate that macrocyclic distance-constrained bis-intercalators are efficient and selective mismatch-binding ligands that can interfere with mismatch-binding enzymes...
- Study design and subject baseline characteristics in the ADVANCE Study: effects of cinacalcet on vascular calcification in haemodialysis patientsJurgen Floege
Division of Nephrology, RWTH University of Aachen, Aachen, Germany
Nephrol Dial Transplant 25:1916-23. 2010..We report the ADVANCE Study design and baseline subject characteristics...
- Neuronal cytoskeleton and synaptic densities are altered after a chronic treatment with the cannabinoid receptor agonist WIN 55,212-2Patricia Tagliaferro
Instituto de Biologia Celular y Neurociencias Prof E De Robertis, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 3 er piso, C1121ABG, Buenos Aires, Argentina
Brain Res 1085:163-76. 2006....
- Cinacalcet reduces plasma intact parathyroid hormone, serum phosphate and calcium levels in patients with secondary hyperparathyroidism irrespective of its severityJ M Frazao
School of Medicine, Porto University, Porto, Portugal
Clin Nephrol 76:233-43. 2011..To evaluate the relationship between the severity of secondary hyperparathyroidism (SHPT) - defined in terms of baseline plasma intact parathyroid hormone (iPTH) level - and the magnitude of response to cinacalcet...
- Functional mechanism of the abscisic acid agonist pyrabactinQi Hao
State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China
J Biol Chem 285:28946-52. 2010..The study provides a framework for the development of novel ABA agonists that may have applicable potentials in agriculture...
- Thirsty plants and beyond: structural mechanisms of abscisic acid perception and signalingKarsten Melcher
Laboratory of Structural Sciences, Van Andel Research Institute, 333 Bostwick Ave N E, Grand Rapids, MI 49503, USA
Curr Opin Struct Biol 20:722-9. 2010....
- Group VIA phospholipase A2 (iPLA2beta) participates in angiotensin II-induced transcriptional up-regulation of regulator of g-protein signaling-2 in vascular smooth muscle cellsZhongwen Xie
Department of Physiology and the Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
J Biol Chem 282:25278-89. 2007..Collectively, our results demonstrate that iPLA2beta participates in Ang II-induced transcriptional up-regulation of RGS2 in VSMC...
- The effect of chronic peripubertal cannabinoid treatment on deficient object recognition memory in rats after neonatal mPFC lesionMiriam Schneider
Department of Psychiatry and Psychotherapy, University of Cologne, 50924 Cologne, Germany
Eur Neuropsychopharmacol 17:180-6. 2007..This study shows that behavioral deviations induced by neonatal mPFC lesions can be exacerbated by pubertal chronic cannabinoid treatment, leading to long-lasting impairments of mnemonic short-term information processing...
- Apoptosis of insulin-secreting cells induced by endoplasmic reticulum stress is amplified by overexpression of group VIA calcium-independent phospholipase A2 (iPLA2 beta) and suppressed by inhibition of iPLA2 betaSasanka Ramanadham
Mass Spectrometry Resource, Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Washington University School of Medicine, Box 8127, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
Biochemistry 43:918-30. 2004..These findings indicate that iPLA(2)beta participates in ER stress-induced apoptosis, a pathway that promotes beta-cell death in diabetes...
- Macrocyclic DNA-mismatch-binding ligands: structural determinants of selectivityAnton Granzhan
UMR176 CNRS, Institut Curie, Centre de Recherche, Centre Universitaire, 91405 Orsay, France
Chemistry 16:878-89. 2010..The study demonstrates that the topology of the ligands plays a crucial role in determining the mismatch-binding affinity and selectivity of the macrocyclic bisintercalators...
- Post-training CB1 cannabinoid receptor agonist activation disrupts long-term consolidation of spatial memories in the hippocampusT T Yim
Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, Canada T1K 3M4
Neuroscience 151:929-36. 2008..Plausible pharmacological interactions between cannabinoids and other neurotransmitter systems and associated plasticity mechanisms are discussed...
- Group VIA calcium-independent phospholipase A2 mediates endothelial cell S phase progressionShane P Herbert
Faculty of Biological Sciences, Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
J Biol Chem 281:35709-16. 2006..Consequently, iPLA2-VIA is a novel regulator of endothelial cell S phase progression, cell cycle residence, and angiogenesis...
- The CB1 receptor agonist, WIN 55,212-2, dose-dependently disrupts object recognition memory in adult ratsJean Ha Baek
Dept of Pharmacology and Toxicology, School of Medical Sciences, University of Otago Medical School, Dunedin, New Zealand
Neurosci Lett 464:71-3. 2009..These results suggest that WIN can interfere with object recognition memory even in adult rats following a single injection of a low dose...
- Structure-activity study in the class of 6-(3'-hydroxyphenyl)naphthalenes leading to an optimization of a pharmacophore model for 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitorsSandrine Marchais-Oberwinkler
8 2 Pharmaceutical and Medicinal Chemistry, Saarland University, P O Box 15 11 50, D 66041 Saarbrucken, Germany
Mol Cell Endocrinol 301:205-11. 2009..Compound 18 also showed a good selectivity toward 17beta-HSD2 and the estrogen receptors alpha and beta...
- Detection of JWH-018 metabolites in smoking mixture post-administration urineTim Sobolevsky
Moscow Antidoping Centre, Elizavetinsky per 10, 105005 Moscow, Russia
Forensic Sci Int 200:141-7. 2010..The parent compound was not detected in urine...
- In vitro phase I metabolism of the synthetic cannabimimetic JWH-018Annette Wintermeyer
Institute of Legal Medicine, Medical Faculty, University of Cologne, Melatengürtel 60 62, 50823 Cologne, Germany
Anal Bioanal Chem 398:2141-53. 2010..N-dealkylation also in combination with both monohydroxylation and dihydrodiol formation of the N-dealkylated metabolite was detected. Finally, a metabolite was found carboxylated at the alkyl side chain...
- A bromoenol lactone suicide substrate inactivates group VIA phospholipase A2 by generating a diffusible bromomethyl keto acid that alkylates cysteine thiolsHaowei Song
Medicine Department Mass Spectrometry Facility, Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
Biochemistry 45:1061-73. 2006....
- Depolarization-induced suppression of excitation in murine autaptic hippocampal neuronesAlex Straiker
Department of Anaesthesiology, University of Washington, Seattle, WA 98195, USA
J Physiol 569:501-17. 2005..With long-term exposure (approximately 18 h), delta9-THC also desensitizes CB1 receptors. Lastly, a functional endocannabinoid transporter is necessary for the expression of DSE...
- Detection of genes involved in biodegradation and biotransformation in microbial communities by using 50-mer oligonucleotide microarraysSung Keun Rhee
Environmental Sciences Division, Oak Ridge National Laboratory, P O Box 2008, Oak Ridge, TN 37831 6038, USA
Appl Environ Microbiol 70:4303-17. 2004....
- Achieving NKF-K/DOQI bone metabolism and disease treatment goals with cinacalcet HClSharon M Moe
Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Kidney Int 67:760-71. 2005....
- Cannabinoids and morphine differentially affect HIV-1 expression in CD4(+) lymphocyte and microglial cell culturesP K Peterson
Minneapolis Medical Research Foundation, 914 S Eighth Street, Minneapolis, MN 55404, USA
J Neuroimmunol 147:123-6. 2004..These in vitro findings support the notion that pharmacologic factors need to be considered in epidemiological studies and animal models that pertain to HIV-1 infection...
- Immunoregulation of a viral model of multiple sclerosis using the synthetic cannabinoid R+WIN55,212J Ludovic Croxford
Department of Microbiology Immunology, Interdepartmental Immunobiology Center, Northwestern University Medical School, 303 E Chicago Avenue, Chicago, IL 60611, USA
J Clin Invest 111:1231-40. 2003..Clinical trials investigating the therapeutic potential of cannabinoids for the symptomatic treatment of MS are ongoing, and this study demonstrates that they may also have potent immunoregulatory properties...
- Outcomes of secondary hyperparathyroidism in chronic kidney disease and the direct costs of treatmentMelanie S Joy
School of Medicine, Division of Nephrology and Hypertension, UNC Kidney Center, Univerisity of North Carolina, Chapel Hill, NC 27599 7155, USA
J Manag Care Pharm 13:397-411. 2007..The number of patients who will be identified and prescribed therapies for complications such as secondary hyperparathyroidism (SHPT) is greater than initially proposed...
- Identity between the Ca2+-independent phospholipase A2 enzymes from P388D1 macrophages and Chinese hamster ovary cellsM A Balboa
Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, California 92093 0601, USA
J Biol Chem 272:8576-80. 1997..Additionally, covalent modification of the CHO enzyme by [3H]bromoenol lactone is dependent on active enzyme as is the P388D1 iPLA2. Finally, both enzymes have the same specific activities under identical experimental conditions...
- Cyclic stretch-induced stress fiber dynamics - dependence on strain rate, Rho-kinase and MLCKChin Fu Lee
Department of Biomedical Engineering, Texas A and M University, College Station, TX 77843 3120, United States
Biochem Biophys Res Commun 401:344-9. 2010..These results shed new light on the mechanism by which stress fibers reorient in response to cyclic stretch in different regions of the actin cytoskeleton...
- Bacterial metabolism of naphthalene: construction and use of recombinant bacteria to study ring cleavage of 1,2-dihydroxynaphthalene and subsequent reactionsR W Eaton
Environmental Research Laboratory, U S Environmental Protection Agency, Gulf Breeze, Florida 32561
J Bacteriol 174:7542-54. 1992..On the basis of the identification of the enzymes encoded by various clones, the gene order for the nah operon was shown to be p, A, B, F, C, E, D...
- The Calcimimetic agent AMG 073 lowers plasma parathyroid hormone levels in hemodialysis patients with secondary hyperparathyroidismWilliam G Goodman
Department of Medicine, Division of Nephrology, Medical Center, UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
J Am Soc Nephrol 13:1017-24. 2002....
- Anaerobic degradation of naphthalene by a pure culture of a novel type of marine sulphate-reducing bacteriumA Galushko
Fakultat fur Biologie, Universitat Konstanz, Germany
Environ Microbiol 1:415-20. 1999..Quantification of substrate consumption, sulphide formation and formed cell mass revealed that naphthalene was completely oxidized with sulphate as the electron acceptor...
- A randomized, double-blind, placebo-controlled study to assess the efficacy and safety of cinacalcet HCl in participants with CKD not receiving dialysisMichel Chonchol
University of Colorado Health Science Center, Division of Renal Diseases and Hypertension, Denver, CO 80262, USA
Am J Kidney Dis 53:197-207. 2009..Secondary hyperparathyroidism is observed in patients with early chronic kidney disease (CKD). This study investigated the safety and efficacy of cinacalcet for secondary hyperparathyroidism in participants with CKD not receiving dialysis...
- Cooperative endocannabinoid production by neuronal depolarization and group I metabotropic glutamate receptor activationTakako Ohno-Shosaku
Department of Cellular Neurophysiology, Graduate School of Medical Science, Kanazawa University, Kanazawa 920 8640, Japan
Eur J Neurosci 15:953-61. 2002..Enhancement of DSI by DHPG was also observed in hippocampal slices. These results suggest that two pathways work in a cooperative manner to release endocannabinoids via a common intracellular cascade...
- Physiologically based pharmacokinetic model for terbinafine in rats and humansMahboubeh Hosseini-Yeganeh
Faculty of Pharmacy, University of Sydney, Sydney, New South Wales 2006, Australia
Antimicrob Agents Chemother 46:2219-28. 2002....
- Tissue distribution of terbinafine in ratsM Hosseini-Yeganeh
Faculty of Pharmacy, College of Health Sciences, University of Sydney, Sydney, NSW, 2006, Australia
J Pharm Sci 90:1817-28. 2001..Uptake of terbinafine into brain (K(p) = 1.3) and muscle (K(p) = 1.0) was significantly lower. In conclusion, terbinafine displays extensive uptake to peripheral tissues, which contributes to the long elimination half-life of this drug...
- Complete sequence and genetic organization of pDTG1, the 83 kilobase naphthalene degradation plasmid from Pseudomonas putida strain NCIB 9816-4Jonathan J Dennis
Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada, T6G 2E9
J Mol Biol 341:753-68. 2004....
- Cannabinoids attenuate capsaicin-evoked hyperalgesia through spinal and peripheral mechanismsL M Johanek
Department of Psychiatry, University of Minnesota, 420 Delaware Street SE, Mayo Mail Code 392, Minneapolis, MN 55455, USA
Pain 93:303-15. 2001..These data show that cannabinoids possess antihyperalgesic properties at doses that alone do not produce antinociception, and are capable of acting at both spinal and peripheral sites...
- Inhibition of p38 MAP kinase by utilizing a novel allosteric binding siteChristopher Pargellis
Department of Biology, Boehringer Ingelheim Pharmaceuticals, Research and Development Center, 900 Ridgebury Road, Ridgefield, Connecticut 06877, USA
Nat Struct Biol 9:268-72. 2002..One of the most potent compounds in this series, BIRB 796, has picomolar affinity for the kinase and low nanomolar inhibitory activity in cell culture...
- Two distinct classes of muscarinic action on hippocampal inhibitory synapses: M2-mediated direct suppression and M1/M3-mediated indirect suppression through endocannabinoid signallingYuko Fukudome
Department of Cellular Neurophysiology, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8640, Japan
Eur J Neurosci 19:2682-92. 2004..Thus, the muscarinic system can influence hippocampal functions by controlling different subsets of inhibitory synapses through the two distinct mechanisms...
- Cannabinoid receptor-mediated inhibition of the rat tail-flick reflex after microinjection into the rostral ventromedial medullaW J Martin
Department of Psychology, Brown University, Providence, RI 02912, USA
Neurosci Lett 242:33-6. 1998..These results demonstrate that the cannabinoid receptor system participates in the descending control of nociception and raise the possibility that actions of endogenous cannabinoids in the RVM may modulate nociceptive responsiveness...
- Pharmacokinetics, pharmacodynamics, and safety of cinacalcet hydrochloride in hemodialysis patients at doses up to 200 mg once dailyRobert Z Harris
Department of Pharmacokinetics and Drug Metabolism, Amgen Inc, Thousand Oaks, CA 91360, USA
Am J Kidney Dis 44:1070-6. 2004..This study investigated the pharmacokinetics, pharmacodynamics, safety, and tolerability of cinacalcet HCl over a dose range of 25 to 300 mg/d in patients receiving dialysis...
- Myosin light chain kinase is involved in lipopolysaccharide-induced disruption of colonic epithelial barrier and bacterial translocation in ratsRaphael Moriez
Institut National de la Recherche Agronomique, Neuro Gastroenterology and Nutrition Unit, 180 chemin de Tournefeuille, BP 3, 31931 Toulouse Cedex 9, France
Am J Pathol 167:1071-9. 2005..Inhibition of MLCK-dependent colonocyte cytoskeleton contraction by ML-7 prevents the LPS-induced alterations of CPP and its subsequent effects...
- Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson's disease: role of CB(1) and TRPV1 receptorsMaria Grazia Morgese
Department of Biomedical Sciences, University of Foggia, Viale Luigi Pinto 1, 71100 Foggia, Italy
Exp Neurol 208:110-9. 2007..Our data indicate that pharmacological blockade of TRPV1 receptors unmasks the anti-dyskinetic effects of FAAH inhibitors and that CB(1) and TRPV1 receptors play opposite roles in levodopa-induced dyskinesias...
- Role of an endoplasmic reticulum Ca(2+)-independent phospholipase A(2) in oxidant-induced renal cell deathBrian S Cummings
Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Am J Physiol Renal Physiol 283:F492-8. 2002..These results are the first to demonstrate the expression and subcellular localization of an ER-iPLA(2). These results also suggest that ER-iPLA(2) functions to protect against oxidant-induced lipid peroxidation and oncosis...
- Ca2+-independent phospholipase A2 enhances store-operated Ca2+ entry in dystrophic skeletal muscle fibersFrançois Xavier Boittin
Laboratory of Pharmacology, Geneva Lausanne School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, 1211 Geneva 4, Switzerland
J Cell Sci 119:3733-42. 2006..The Ca2+-independent phospholipase A2 pathway therefore appears as an attractive target to reduce excessive Ca2+ influx and subsequent degeneration occurring in dystrophic fibers...
- Studies on the different modes of action of the anticoagulant protease inhibitors DX-9065a and Argatroban. I. Effects on thrombin generationHajime Nagashima
New Product Research Laboratories II, Daiichi Pharmaceutical Co, Ltd, Tokyo 104 8369, Japan
J Biol Chem 277:50439-44. 2002..This study demonstrates differential inhibition of thrombin generation by fXa and thrombin inhibitors and has implications for the pharmacological regulation of blood coagulation by the anticoagulant protease inhibitors...
- Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non-small cell lung cancer growth and metastasisAnju Preet
Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
Cancer Prev Res (Phila) 4:65-75. 2011..These results suggest that CB1 and CB2 could be used as novel therapeutic targets against NSCLC...
- D2 dopamine receptor activation facilitates endocannabinoid-mediated long-term synaptic depression of GABAergic synaptic transmission in midbrain dopamine neurons via cAMP-protein kinase A signalingBin Pan
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
J Neurosci 28:14018-30. 2008....
- Red yeast rice increases excretion of bile acids in hamstersKa Ying Ma
Food and Nutritional Sciences Program, Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
Biomed Environ Sci 22:269-77. 2009..To investigate the hypocholesterolemic activity of red yeast rice (RYR) and its underlying mechanism...
- Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: an integrated analysis of two double-blind, randomised controlled trialsJon L Pryor
University of Minnesota, Minneapolis, MN 55455, USA
Lancet 368:929-37. 2006..No drugs are approved for treatment of premature ejaculation. Our aim was to determine the efficacy and tolerability of on-demand dapoxetine in patients with severe premature ejaculation...
- Cinacalcet HCl and concurrent low-dose vitamin D improves treatment of secondary hyperparathyroidism in dialysis patients compared with vitamin D alone: the ACHIEVE study resultsSteven Fishbane
Winthrop University Hospital, Department of Nephrology, Mineola, New York 11501, USA
Clin J Am Soc Nephrol 3:1718-25. 2008..The ACHIEVE study was designed to test two treatment strategies for achieving KDOQI goals...
- Chronic exposure to cannabinoids during adolescence but not during adulthood impairs emotional behaviour and monoaminergic neurotransmissionFrancis Rodriguez Bambico
Neurobiological Psychiatry Unit, Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, Canada H3A1A1
Neurobiol Dis 37:641-55. 2010..These suggest that long-term exposure to cannabinoids during adolescence induces anxiety-like and depression-like behaviours in adulthood and that this may be instigated by serotonergic hypoactivity and noradrenergic hyperactivity...
- Cyclooxygenases, thromboxane, and atherosclerosis: plaque destabilization by cyclooxygenase-2 inhibition combined with thromboxane receptor antagonismKarine M Egan
Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
Circulation 111:334-42. 2005..We addressed this issue and the role of TxA2 in the promotion and regression of diffuse, established atherosclerosis in Apobec-1/LDLR double KOs (DKOs)...
- Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemiaJudith Branger
Department of Infectious Diseases, Tropical Medicine, and AIDS, Academic Medical Center, and CLB and Laboratory for Clinical and Experimental Immunology, University of Amsterdam, Amsterdam, The Netherlands
J Immunol 168:4070-7. 2002..Furthermore, the anti-inflammatory potential of an oral p38 MAPK inhibitor in humans in vivo suggests that p38 MAPK inhibitors may provide a new therapeutic option in the treatment of inflammatory diseases...
- Pharmacodynamics of the type II calcimimetic compound cinacalcet HClEdward F Nemeth
Amgen, Inc, Thousand Oaks, CA 91320 1799, USA
J Pharmacol Exp Ther 308:627-35. 2004..The present findings provide compelling evidence that cinacalcet HCl is a potent and stereoselective activator of the parathyroid CaR and, as such, might be beneficial in the treatment of hyperparathyroidism...
- Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammalian iPLChristopher M Jenkins
Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 277:32807-14. 2002....
- Suppression by WIN55212-2, a cannabinoid receptor agonist, of inflammatory reactions in mouse ear: Interference with the actions of an endogenous ligand, 2-arachidonoylglycerolSaori Oka
Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Tsukui gun, Kanagawa 199 0195, Japan
Eur J Pharmacol 538:154-62. 2006..These results suggest that the anti-inflammatory activity of WIN55212-2 is attributable, at least in part, to interference with the actions of the endogenous ligand, 2-arachidonoylglycerol...
- Calcium-independent phospholipase A2 modulates cytosolic oxidant activity and contractile function in murine skeletal muscle cellsMing C Gong
Dept of Physiology, Univ of Kentucky Medical Center, 800 Rose St, Lexington, KY 40536, USA
J Appl Physiol 100:399-405. 2006..These findings suggest that constitutively expressed iPLA2 modulates oxidant activity in skeletal muscle fibers by supporting ROS production, thereby influencing contractile properties and fatigue characteristics...
- Combined genomic and proteomic approaches identify gene clusters involved in anaerobic 2-methylnaphthalene degradation in the sulfate-reducing enrichment culture N47Drazenka Selesi
Institute of Groundwater Ecology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
J Bacteriol 192:295-306. 2010..The present work provides the first insight into the genetic basis of anaerobic 2-methylnaphthalene metabolism and delivers implications for understanding contaminant degradation...
- Behavioural disturbances and altered Fos protein expression in adult rats after chronic pubertal cannabinoid treatmentNico Wegener
Brain Research Institute, Department of Neuropharmacology, University of Bremen, Bremen, Germany
Brain Res 1253:81-91. 2009....
- Polychlorinated naphthalenes (PCNs) in riverine and marine sediments of the Laizhou Bay area, North ChinaXiaohui Pan
Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China
Environ Pollut 159:3515-21. 2011..In marine sediments, it was suggested that PCNs along the coast of Laizhou Bay were mainly controlled by riverine input. While in the central bay, PCN distributions were possibly impacted by combined multiple factors...
- Early initiation of cinacalcet for the treatment of secondary hyperparathyroidism in hemodialysis patients: a three-year clinical experienceLeonardo Lucchi
Nephrology and Dialysis, Internal Medicine, Azienda Policlinico, Modena, Italy
Artif Organs 35:1186-93. 2011..These results suggest that the metabolic control obtained with low-dose CN administered early in the course of SHPT can be maintained or increased over time...
- The calcimimetic AMG 641 abrogates parathyroid hyperplasia, bone and vascular calcification abnormalities in uremic ratsCharles Henley
Department of Metabolic Disorders, Amgen Inc, Thousand Oaks, CA 91320, USA
Eur J Pharmacol 616:306-13. 2009..These results suggest that calcimimetics can reduce the development of vascular calcification, parathyroid hyperplasia and bone abnormalities associated with secondary hyperparathyroidism...
- Economic analysis of cinacalcet in combination with low-dose vitamin D versus flexible-dose vitamin D in treating secondary hyperparathyroidism in hemodialysis patientsTheresa I Shireman
Department of Preventive Medicine and Public Health and the Landon Center on Aging, University of Kansas Medical Center, Kansas City, KS, USA
Am J Kidney Dis 56:1108-16. 2010..The economic implications of these treatment regimens have not been explored...
- Meta-analysis of biochemical and patient-level effects of calcimimetic therapyGiovanni F M Strippoli
NHMRC Centre for Clinical Research Excellence in Renal Medicine, Cochrane Renal Group, School of Public Health, University of Sydney, Australia
Am J Kidney Dis 47:715-26. 2006..We conducted a meta-analysis to evaluate outcomes of therapy with these novel agents...
- Simultaneous control of PTH and CaxP Is sustained over three years of treatment with cinacalcet HClStuart M Sprague
Evanston Northwestern Healthcare and Northwestern University Feinberg School of Medicine, Evanston, IL 60201, USA
Clin J Am Soc Nephrol 4:1465-76. 2009..Final efficacy analysis was at week 180...
- Agonist-induced calcium entry correlates with STIM1 translocationKehinde Ross
Dermatological Sciences, Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom
J Cell Physiol 211:569-76. 2007..Thus by differentially regulating store-refilling after agonist-mediated depletion, LPA and UTP may exert distinct effects on the duration of STIM1 localization at the plasma membrane, and thus, on the magnitude and duration of ACE...
- Dose determination of cinacalcet hydrochloride in Japanese hemodialysis patients with secondary hyperparathyroidismTakashi Akiba
Department of Blood Purification and Internal Medicine, Kidney Center, Tokyo Women s Medical University, Tokyo, Japan
Ther Apher Dial 12:117-25. 2008..On the basis of both efficacy and safety results, 25 mg has been identified as the optimal starting dose of cinacalcet for Japanese hemodialysis patients with secondary hyperparathyroidism...
- Polychlorinated naphthalenes and other dioxin-like compounds in Elbe River sedimentsWerner Brack
UFZ Helmholtz Centre for Environmental Research, Leipzig, Germany
Environ Toxicol Chem 27:519-28. 2008..The investigation focused on polychlorinated naphthalenes (PCNs) that have not been determined previously in the Elbe River...
- 1-Pentyl-3-phenylacetylindoles and JWH-018 share in vivo cannabinoid profiles in miceJenny L Wiley
RTI International, Research Triangle Park, NC 27709 2194, USA
Drug Alcohol Depend 123:148-53. 2012..Although abused by humans, most published research on this class of compounds has been performed in vitro. The purpose of this study was to evaluate a novel series of 1-pentyl-3-phenylacetylindoles in mice...
- Atmospheric pressure photoionization mass spectrometry. Ionization mechanism and the effect of solvent on the ionization of naphthalenesTiina J Kauppila
Viikki Drug Discovery Technology Center, Department of Pharmacy, University of Helsinki, Finland
Anal Chem 74:5470-9. 2002..atmospheric pressure photoionization and the effect of solvent on the ionization efficiency was studied using 7 naphthalenes and 13 different solvent systems...
- Cannabinoid Regulation of Basal Ganglia Glutamate and GABASCOTT RAWLS; Fiscal Year: 2007..Our outcomes will be a first step in determining whether blocking endocannabinoid inactivation offers any therapeutic advantage over direct activation of cannabinoid receptors with marijuana. [unreadable] [unreadable] [unreadable]..
- LUNG INJURY BY NAPHTHALENESAlan Buckpitt; Fiscal Year: 2009..Human exposure to naphthalenes occurs from a variety of sources including cigarette smoke and polluted air...
- METABOLISM & CARCINOGENICITY OF HALOAROMATIC POLLUTANTSStephen Safe; Fiscal Year: 1980The metabolically-mediated toxicity of halogenated aromatic pollutants (polyhalogenated biphenyls, benzenes, naphthalenes and p-terphenyls) depends on a variety of factors which include the nature of the halogen atom, the nature of the ..
- Drug discrimination and THC withdrawal in monkeysLANCE MCMAHON; Fiscal Year: 2005..abstract_text> ..
- Pharmacotherapy of Cannabinoid Withdrawal: Pre-Clinical StudiesLance R McMahon; Fiscal Year: 2010..Collectively, these specific aims provide a framework for developing novel pharmacotherapies of marijuana withdrawal that could markedly decrease marijuana use and dependence. ..
- Can beta-lactam antibiotics decrease morphine physical dependence?SCOTT RAWLS; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- PRIMARY HYPERPARATHYROIDISM: NON-CLASSICAL MANIFESTATIONSShonni Silverberg; Fiscal Year: 2009..abstract_text> ..
- DIURNAL AND PULSATILE PTH SECRETION IN RENAL FAILUREWilliam Goodman; Fiscal Year: 2001....
- Tools for mapping transcriptional networksUri Alon; Fiscal Year: 2006..We expect that the analysis tools and concepts developed in E. coli will be very useful in mapping complex regulatory circuits in other cell types. [unreadable] [unreadable]..
- Nasal dosimetry of diacetyl and butyric acid vaporsJohn Morris; Fiscal Year: 2005....
- NON-OPIOID ANALGESICS DERIVED FROM IMPROGANLINDSAY HOUGH; Fiscal Year: 2006..These experiments will help to discover the mechanism of action of this novel class of agents, and lead to the development of new pharmacotherapies for pain. ..
- Azinomycins - Total Synthesis and Mechanism of ActionRobert Coleman; Fiscal Year: 2007..abstract_text> ..
- Asymmetric Synthesis of Cytotoxic Natural ProductsRobert Coleman; Fiscal Year: 2005..abstract_text> ..
- TOWARD THE OPTIMAL TIMING OF INITIATION OF DIALYSISGlenn Chertow; Fiscal Year: 2003..The investigators have provided additional preliminary studies and have provided an extensive, detailed example of how the Monte Carlo models will be specified, validated, and optimized. ..
- Developmental Psychopharmacology of AntipsychoticsJENNY WILEY; Fiscal Year: 2007..This information will help to provide a more rational basis for making treatment decisions concerning children and adolescents who may benefit from treatment with an antipsychotic. [unreadable] [unreadable]..
- HISTAMINERGIC MECHANISMS OF ANTINOCICEPTIONLINDSAY HOUGH; Fiscal Year: 2009..abstract_text> ..
- Leptin Action and Resistance in POMC-NeuronsSHANE HENTGES; Fiscal Year: 2005..abstract_text> ..
- Joint Action Analysis of Poly-drug WithdrawalRobert Raffa; Fiscal Year: 2006..g., electrophysiologic or molecular biology techniques. An improved understanding of how withdrawal is influenced by poly-drug abuse could lead to development of enhanced clinical treatment. ..
- Mechanisms of Growth Factor-Estrogen Receptor CrosstalkStephen Safe; Fiscal Year: 2006..abstract_text> ..
- DESIGN AND SYNTHESIS OF NONPEPTIDE PROTEASE INHIBITORSArun K Ghosh; Fiscal Year: 2010..This research integrates organic synthesis, protein-ligand x-ray crystallography, molecular modeling and in-depth virus and cell-biological studies to design the next generation of HIV-1 protease inhibitors. ..
- MECHANISMS OF CELL INJURY IN BURN COMPLICATED BY SEPSISDeborah Carlson; Fiscal Year: 2006..The proposed work focuses on five specific aims to increase our understanding of the cellular events involved in burn and sepsis-related myocardial injury. ..
- Disorders of Syntactic ComprehensionDAVID NORMAN CAPLAN; Fiscal Year: 2011..The results could have important consequences for howwe think of these disorders and the neural organization that supports these functions. ..
- Regulation of vascular smooth muscle calcium sensitivityPaul H Ratz; Fiscal Year: 2010..The Specific Aim of this study will be to test the hypothesis that ROK and PKCzeta both mediate KCI- induced Ca sensitization of FA, and that iPLA2 and PI3K are required as upstream activators of ROK and PKCzeta. ..
- Novel Inhibitors of Akt Signaling in Pancreatic CancerGarth Powis; Fiscal Year: 2009..The PtdIns-3-kinase/Akt signaling pathway is upregulated in many pancreatic cancers making it an ideal target for drugs to treat the disease. ..
- MECHANISMS OF CANNABINOID'S ANTIEMETIC ACTIONSNISSAR DARMANI; Fiscal Year: 2007..The results will have important implications for the therapeutic utility of these "agonist antiemetics". [unreadable] [unreadable]..
- Synthesis of Polyketides and TerpenesDavid A Evans; Fiscal Year: 2010..As a consequence, organic synthesis is a critical discipline that continues to have an important impact on the fields of both medicine and biology. ..
- NEW AMINO-PROTECTING GROUPS AND COUPLING REAGENTSLOUIS CARPINO; Fiscal Year: 2009..Microwave irradiation is expected to allow for the most efficient syntheses, especially with Bsmoc and HOAt-based chemistry. ..
- TOXICOLOGY OF ENVIRONMENT CONTAMINANTSStephen Safe; Fiscal Year: 2007..The proposed training program will continue to provide trainees with a challenging academic and research environment that will prepare them for future careers in academic, industry and government. ..
- Gender differences in the interactions between endocannabinoids and stressCecilia Hillard; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- Nanoscale-Natural Products ChemistryTADEUSZ MOLINSKI; Fiscal Year: 2009....
- ANTIFUNGALS FROM MARINE INVERTEBRATES--AIDS ADJUVANTSTadeusz F Molinski; Fiscal Year: 2010..Optimized leads identified from those libraries will be advanced to in vitro and in vivo trials. ..
- Alcoholic Hepatitis: Molecular MechanismsStephen Safe; Fiscal Year: 2008..The long-term goal of this project is to device appropriate therapies that will prevent neutrophilic steatohepatitis in chronic alcoholics by reducing neutrophil infiltration into liver. [unreadable] [unreadable] [unreadable]..
- Opioids: Relative Reinforcing Strength and DependenceCarol Paronis; Fiscal Year: 2008..Results of these studies will improve our ability to assess the effectiveness with which agonist-based medications may combat its addictive power. ..
- Sex Differences in Endocannabioid-Mediated BehaviorsChristian Reich; Fiscal Year: 2008..Fear conditioning will be performed with established classical-conditioning protocols. [unreadable] [unreadable]..
- Monellin activates the human sweet taste receptorEmeline Maillet; Fiscal Year: 2008..Knowledge of the structure/function relationship of TIRs may be valuable in the development of novel, low caloric sweeteners to help fight against diet-related disorders such as obesity and diabetes. ..
- CATCH: Mechanochemistry and Regulation in Smooth MuscleThomas Butler; Fiscal Year: 2008..4) Determination of the extent of involvement of myosin crossbridges in catch force maintenance by measurements of changes in orientation of fluorescent probes attached to the regulatory light chain. ..
- CA2+ RECEPTOR, PTHRP & MALIGNANCY-INDUCED OSTEOLYSISEdward M Brown; Fiscal Year: 2004..abstract_text> ..
- Function of a Novel Matrix Junction in Endothelial CellsJonathan Jones; Fiscal Year: 2005..In aim 3, we will analyze the function(s) of components of the VMA in angiogenesis in vivo. These studies will provide new insight into the role of integrin/matrix interactions in angiogenesis. ..
- PAIN MODULATION BY ENDOGENOUS CANNABINOIDSJ Walker; Fiscal Year: 2004..The experiments will determine the peripheral fiber types and the spinal cord neurons and neural pathways that induce the release of anandamide. ..
- NEUROLOGICAL BASIS OF PAIN: ROLE OF CANNABINOIDSJ Walker; Fiscal Year: 2003..The results of these studies will reveal mechanisms by which cannabinoids modulate the pathological pain, and suggests future studies directed at determining the role of endocannabinoids in pain processing. ..
- ESTROGEN INDUCED RESPONSES VIA ER/SPL COMPLEXESStephen Safe; Fiscal Year: 2002..These results will ultimately facilitate design of chemotherapeutic approaches which target specific genes. ..
- P450 MEDIATED LUNG TOXICITYAlan Buckpitt; Fiscal Year: 2002....
- MARIJUANA WITHDRAWALJ Walker; Fiscal Year: 2002..In addition, the investigations in the hippocampus may have relevance to learning and memory and thus have implications for certain mental illnesses such as Alzheimer's disease or other diseases that affect mental health. ..
- ASYMMETRIC SYNTHESIS OF VANCOMYCIN ANTIBIOTICSDavid Evans; Fiscal Year: 2001..During the course of this project we intend to confirm (correct) the absolute stereochemical assignments of the principal members of this family by total synthesis. ..
- MECHANISMS OF CANNABINOIDS ANTIEMETIC ACTIONSNISSAR DARMANI; Fiscal Year: 2001..The results will define an important role for the cannabinoid receptors in the vomiting circuits and may implicate an antiemetic role for the endogenous cannabinoids. ..
- ALKYL PCDFS--INHIBITION OF MAMMARY CANCERStephen Safe; Fiscal Year: 2001..Thus the proposed studies will define a new mechanism-based class of antiestrogens that can be used alone or in combination with tamoxifen for treatment of breast and endometrial cancer. ..
- DEVELOPMENT OF LIGAND ASSISTED ASYMMETRIC SYNTHESESArun Ghosh; Fiscal Year: 2001..Besides the broad range of scope and generality, this line of research will provide excellent opportunities to teach and train graduate and undergraduate students in the laboratory. ..
- ACQUISITION OF MIRCOARRAY SPOTTER, READER, SOFTWAREAlan Buckpitt; Fiscal Year: 2001..abstract_text> ..
- MICROPET: HIGH RESOLUTION SMALL ANIMAL PET SCANNERNed Kalin; Fiscal Year: 2001..This scanner will also enhance research efforts in such wide-ranging areas as cardiology, oncology neurology, radiology and medical physics. ..
- Role of Central CRH in Stress-Induced BehaviorNed Kalin; Fiscal Year: 2006....
- Chronic Cannabinoids, Tumor Growth and HyperalgesiaDARRYL HAMAMOTO; Fiscal Year: 2005..Positive results from these studies would suggest that cannabinoids could be useful for the treatment of cancer pain. ..
- Dermal Exposure to 1,6-Hexamethylene DiisocyanateLeena Nylander French; Fiscal Year: 2005..abstract_text> ..
- Brain Endocannabinoids and Chronic StressCecilia Hillard; Fiscal Year: 2005..The successful completion of these studies will enhance our understanding of the processes involved in the adaptation of the brain to chronic stress. ..
- ASYMMETRIC SYNTHESIS OF IONOPHORE/MACROLIDE ANTIBIOTICSDavid Evans; Fiscal Year: 2005..Our goal has been to set in place all of the reactions necessary for the rapid assemblage of any polyketide target structure. ..
- Coactivation of Estrogen Receptor alpha/Sp1Stephen Safe; Fiscal Year: 2006..abstract_text> ..
- 2,3,7,8,--TCDD Effects on the Estrogenic ResponsesStephen Safe; Fiscal Year: 2006..The proposed Aims will address important mechanistic considerations on IDRE-independent inhibitory AhR-ERa crosstalk and pathways critical for inhibition of mammary tumor growth by SAhRMs. ..
- PHARMACOLOGY OF BOVINE PARATHYROID CA++ RECEPTORSEdward M Brown; Fiscal Year: 2002....
- Biology and Drug Resistance of Candida BiofilmsMahmoud Ghannoum; Fiscal Year: 2005..albicans biofilms. By studying biofilm model systems and applying this knowledge to the patient population, we will gain a wealth of data about the biology and drug resistance of C. albicans in biofilms. ..
- MECHANISM OF IL-12 INHIBITION BY CANDIDA ALBICANSMahmoud Ghannoum; Fiscal Year: 2009..Data obtained from these studies will lead to a better understanding of the complex immune response to CA infection and may identify novel prevention/treatment strategies for candidiasis. ..
- INHIBITION OF PTH SECRETION: CaR AND THE CYTOSKELETONEdward M Brown; Fiscal Year: 2007..Phosphorylation of caveolin-1 under high Ca 2+ conditions may anchor the CaR-PTH unit to the plasma membrane, limiting PTH secretion. ..
- CALCIUM RECEPTOR SIGNAL RECOGNITION AND TRANSDUCTIONEdward M Brown; Fiscal Year: 2006..abstract_text> ..
- CA2+-RECEPTOR: IMMUNE MODULATION IN VIVO AND IN VITROEdward M Brown; Fiscal Year: 2007..3) To develop an animal model of activating and/or inactivating antibodies by immunization with the CaR's extracellular domain. [unreadable] [unreadable]..
- Electroporation and transcutaneous extraction of drugsSATHYANARAYANA MURTHY; Fiscal Year: 2006..Further we also plan to correlate the time course of unbound ciprofloxacin in dermal ECF with that in synovial fluid determined by microdialysis in rat. [unreadable] [unreadable] [unreadable]..
- Improving genomic prediction models in breast cancerJohn Olson; Fiscal Year: 2005....
- REGULATION OF DETRUSOR SMOOTH MUSCLE CONTRACTIONPAUL RATZ; Fiscal Year: 2005..Collectively, these studies will provide new insights into the cellular mechanisms regulating DSM contractions. ..
- Developing Biomarker-Based Prognostics In Breast CancerJohn Olson; Fiscal Year: 2008..abstract_text> ..