naphthalenes

Summary

Summary: Two-ring crystalline hydrocarbons isolated from coal tar. They are used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, preservatives, and, formerly, as topical antiseptics.

Top Publications

  1. ncbi Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis
    Geoffrey A Block
    Denver Nephrologists, Denver, USA
    N Engl J Med 350:1516-25. 2004
  2. ncbi Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes
    Birgit Heltweg
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 66:4368-77. 2006
  3. doi Combined therapy with cinacalcet and low doses of vitamin D sterols in patients with moderate to severe secondary hyperparathyroidism
    Geoffrey A Block
    Denver Nephrologists, Denver, CO 80230, USA
    Nephrol Dial Transplant 23:2311-8. 2008
  4. doi Cinacalcet hydrochloride treatment significantly improves all-cause and cardiovascular survival in a large cohort of hemodialysis patients
    Geoffrey A Block
    Denver Nephrology Research Division, Denver, Colorado 80230, USA
    Kidney Int 78:578-89. 2010
  5. pmc Effects of cinacalcet and concurrent low-dose vitamin D on FGF23 levels in ESRD
    James B Wetmore
    University of Kansas Medical Center, MS 3002, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Clin J Am Soc Nephrol 5:110-6. 2010
  6. ncbi Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesis
    Yannick Marchalant
    Department of Psychology, The Ohio State University, Columbus, 43210, USA
    Neurobiol Dis 34:300-7. 2009
  7. doi Posttraining activation of CB1 cannabinoid receptors in the CA1 region of the dorsal hippocampus impairs object recognition long-term memory
    Julia R Clarke
    Centro de Memoria, Instituto de Pesquisas Biomédicas, Pontificia Universidade Catolica do Rio Grande do Sul, Av Ipiranga 6690, RS 90610 000 Porto Alegre, Brazil
    Neurobiol Learn Mem 90:374-81. 2008
  8. pmc Paricalcitol versus cinacalcet plus low-dose vitamin D therapy for the treatment of secondary hyperparathyroidism in patients receiving haemodialysis: results of the IMPACT SHPT study
    Markus Ketteler
    Division of Nephrology, Klinikum Coburg, Coburg, Germany
    Nephrol Dial Transplant 27:3270-8. 2012
  9. doi Stable-isotope probing of the polycyclic aromatic hydrocarbon-degrading bacterial guild in a contaminated soil
    Maiysha D Jones
    Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, CB 7431 Chapel Hill, NC 27599 7431, USA
    Environ Microbiol 13:2623-32. 2011
  10. pmc Opposing actions of chronic Delta9-tetrahydrocannabinol and cannabinoid antagonists on hippocampal long-term potentiation
    Alexander F Hoffman
    United States Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, Cellular Neurobiology Branch, Electrophysiology Research Unit, Baltimore, Maryland 21224, USA
    Learn Mem 14:63-74. 2007

Research Grants

  1. LUNG INJURY BY NAPHTHALENES
    Alan Buckpitt; Fiscal Year: 2009
  2. LUNG INJURY BY NAPHTHALENES
    Alan Buckpitt; Fiscal Year: 1993
  3. LUNG INJURY BY NAPHTHALENES
    Alan Buckpitt; Fiscal Year: 2004
  4. Treatment of Cannabinoid Withdrawal in Rhesus Monkeys
    LANCE MCMAHON; Fiscal Year: 2007
  5. Nicotine dependence: neuropharmacology in monkeys
    Lance R McMahon; Fiscal Year: 2010
  6. Drug discrimination and THC withdrawal in monkeys
    LANCE MCMAHON; Fiscal Year: 2005
  7. Pharmacotherapy of Cannabinoid Withdrawal: Pre-Clinical Studies
    Lance R McMahon; Fiscal Year: 2010
  8. Treatment of Cannabinoid Withdrawal in Rhesus Monkeys
    Lance R McMahon; Fiscal Year: 2010
  9. Cannabinoid Regulation of Basal Ganglia Glutamate and GABA
    SCOTT RAWLS; Fiscal Year: 2007
  10. EXOGENOUS AND ENDOGENOUS CANNABINOIDS--A COMPARISON
    TORBJORN JARBE; Fiscal Year: 2000

Detail Information

Publications260 found, 100 shown here

  1. ncbi Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis
    Geoffrey A Block
    Denver Nephrologists, Denver, USA
    N Engl J Med 350:1516-25. 2004
    ..We report the results of two identical randomized, double-blind, placebo-controlled trials evaluating the safety and effectiveness of the calcimimetic agent cinacalcet hydrochloride...
  2. ncbi Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes
    Birgit Heltweg
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 66:4368-77. 2006
    ..Cambinol was well tolerated in mice and inhibited growth of Burkitt lymphoma xenografts. Inhibitors of NAD-dependent deacetylases may constitute novel anticancer agents...
  3. doi Combined therapy with cinacalcet and low doses of vitamin D sterols in patients with moderate to severe secondary hyperparathyroidism
    Geoffrey A Block
    Denver Nephrologists, Denver, CO 80230, USA
    Nephrol Dial Transplant 23:2311-8. 2008
    ....
  4. doi Cinacalcet hydrochloride treatment significantly improves all-cause and cardiovascular survival in a large cohort of hemodialysis patients
    Geoffrey A Block
    Denver Nephrology Research Division, Denver, Colorado 80230, USA
    Kidney Int 78:578-89. 2010
    ..v. vitamin D. Definitive proof, however, of a survival advantage awaits the performance of randomized clinical trials...
  5. pmc Effects of cinacalcet and concurrent low-dose vitamin D on FGF23 levels in ESRD
    James B Wetmore
    University of Kansas Medical Center, MS 3002, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Clin J Am Soc Nephrol 5:110-6. 2010
    ..The effects of various treatments for secondary hyperparathyroidism on FGF23 levels in ESRD have not been examined in a clinical trial...
  6. ncbi Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesis
    Yannick Marchalant
    Department of Psychology, The Ohio State University, Columbus, 43210, USA
    Neurobiol Dis 34:300-7. 2009
    ..Our results provide insight into the role of the endocannabinoid and vanilloid systems upon two different and detrimental aspects of normal and pathological aging, chronic neuroinflammation and decline in neurogenesis...
  7. doi Posttraining activation of CB1 cannabinoid receptors in the CA1 region of the dorsal hippocampus impairs object recognition long-term memory
    Julia R Clarke
    Centro de Memoria, Instituto de Pesquisas Biomédicas, Pontificia Universidade Catolica do Rio Grande do Sul, Av Ipiranga 6690, RS 90610 000 Porto Alegre, Brazil
    Neurobiol Learn Mem 90:374-81. 2008
    ..Our data indicate that activation of hippocampal CB1 receptors early after training hampers consolidation of object recognition memory...
  8. pmc Paricalcitol versus cinacalcet plus low-dose vitamin D therapy for the treatment of secondary hyperparathyroidism in patients receiving haemodialysis: results of the IMPACT SHPT study
    Markus Ketteler
    Division of Nephrology, Klinikum Coburg, Coburg, Germany
    Nephrol Dial Transplant 27:3270-8. 2012
    ....
  9. doi Stable-isotope probing of the polycyclic aromatic hydrocarbon-degrading bacterial guild in a contaminated soil
    Maiysha D Jones
    Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, CB 7431 Chapel Hill, NC 27599 7431, USA
    Environ Microbiol 13:2623-32. 2011
    ....
  10. pmc Opposing actions of chronic Delta9-tetrahydrocannabinol and cannabinoid antagonists on hippocampal long-term potentiation
    Alexander F Hoffman
    United States Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, Cellular Neurobiology Branch, Electrophysiology Research Unit, Baltimore, Maryland 21224, USA
    Learn Mem 14:63-74. 2007
    ..These data define consequences of repeated Delta(9)-THC exposure for synaptic plasticity in the hippocampus that may help explain memory impairments in humans following chronic marijuana use...
  11. ncbi Outcomes of secondary hyperparathyroidism in chronic kidney disease and the direct costs of treatment
    Melanie S Joy
    School of Medicine, Division of Nephrology and Hypertension, UNC Kidney Center, Univerisity of North Carolina, Chapel Hill, NC 27599 7155, USA
    J Manag Care Pharm 13:397-411. 2007
    ..The number of patients who will be identified and prescribed therapies for complications such as secondary hyperparathyroidism (SHPT) is greater than initially proposed...
  12. pmc Cinacalcet HCl and concurrent low-dose vitamin D improves treatment of secondary hyperparathyroidism in dialysis patients compared with vitamin D alone: the ACHIEVE study results
    Steven Fishbane
    Winthrop University Hospital, Department of Nephrology, Mineola, New York 11501, USA
    Clin J Am Soc Nephrol 3:1718-25. 2008
    ..ACHIEVE included a 6-week screening phase, including vitamin D washout, a 16-week dose-titration phase, and an 11-week assessment phase...
  13. doi The ADVANCE study: a randomized study to evaluate the effects of cinacalcet plus low-dose vitamin D on vascular calcification in patients on hemodialysis
    Paolo Raggi
    Division of Cardiology, Emory University, Atlanta, GA, USA
    Nephrol Dial Transplant 26:1327-39. 2011
    ....
  14. ncbi Achieving NKF-K/DOQI bone metabolism and disease treatment goals with cinacalcet HCl
    Sharon M Moe
    Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Kidney Int 67:760-71. 2005
    ....
  15. ncbi Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammalian iPL
    Christopher M Jenkins
    Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 277:32807-14. 2002
    ....
  16. pmc nag genes of Ralstonia (formerly Pseudomonas) sp. strain U2 encoding enzymes for gentisate catabolism
    N Y Zhou
    School of Biological Sciences, University of Wales, Bangor, Gwynedd LL57 2UW, Wales, United Kingdom
    J Bacteriol 183:700-8. 2001
    ..NagJ is homologous to a glutathione S-transferase, and NagM and NagN are proteins homologous to each other and to other proteins of unknown function. Downstream of the operon is a partial sequence with homology to a transposase...
  17. ncbi Inhibition of nitric oxide production in RAW264.7 macrophages by cannabinoids and palmitoylethanolamide
    R A Ross
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, AB25 2ZD, Scotland, Aberdeen, UK
    Eur J Pharmacol 401:121-30. 2000
    ..In contrast, the inhibition by palmitoylethanolamide does not appear to be mediated by cannabinoid receptors...
  18. pmc Correlated species differences in the effects of cannabinoid ligands on anxiety and on GABAergic and glutamatergic synaptic transmission
    J Haller
    Institute of Experimental Medicine, Department of Behavioral Neurobiology, 1450 Budapest, PO Box 67, Hungary
    Eur J Neurosci 25:2445-56. 2007
    ..We suggest that the anxiety-related effects of cannabinoids depend on the relative cannabinoid responsiveness of GABAergic and glutamatergic neurotransmission...
  19. ncbi CB1 cannabinoid receptors mediate anxiolytic effects: convergent genetic and pharmacological evidence with CB1-specific agents
    J Haller
    Institute of Experimental Medicine, Budapest, Hungary
    Behav Pharmacol 15:299-304. 2004
    ..This suggests that agonists of the former, or antagonists of the latter, are promising new compounds in the pharmacotherapy of anxiety...
  20. pmc Long-term treatment with cinacalcet and conventional therapy reduces parathyroid hyperplasia in severe secondary hyperparathyroidism
    Mario Meola
    Department of Internal Medicine, S Anna School of Advanced Studies, Nephrology and Dialysis Unit, University of Pisa, Italy
    Nephrol Dial Transplant 24:982-9. 2009
    ....
  21. doi Dose determination of cinacalcet hydrochloride in Japanese hemodialysis patients with secondary hyperparathyroidism
    Takashi Akiba
    Department of Blood Purification and Internal Medicine, Kidney Center, Tokyo Women s Medical University, Tokyo, Japan
    Ther Apher Dial 12:117-25. 2008
    ..On the basis of both efficacy and safety results, 25 mg has been identified as the optimal starting dose of cinacalcet for Japanese hemodialysis patients with secondary hyperparathyroidism...
  22. doi Cannabinoid receptor agonist 13, a novel cannabinoid agonist: first in human pharmacokinetics and safety
    Anne Gardin
    Novartis Institutes for BioMedical Research, Basel, CH 4002, Switzerland
    Drug Metab Dispos 37:827-33. 2009
    ..Food intake increased CRA13 C(max) and AUC(0 - tz) by approximately 2-fold, whereas t(max) was unaffected...
  23. pmc Cinacalcet effectively reduces parathyroid hormone secretion and gland volume regardless of pretreatment gland size in patients with secondary hyperparathyroidism
    Hirotaka Komaba
    Division of Nephrology and Kidney Center, Kobe University School of Medicine, Kobe, Japan
    Clin J Am Soc Nephrol 5:2305-14. 2010
    ..However, it has not been proven whether parathyroid gland size predicts response to therapy and whether cinacalcet is capable of inducing a reduction in parathyroid volume...
  24. pmc Functional mechanism of the abscisic acid agonist pyrabactin
    Qi Hao
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China
    J Biol Chem 285:28946-52. 2010
    ..The study provides a framework for the development of novel ABA agonists that may have applicable potentials in agriculture...
  25. pmc Thirsty plants and beyond: structural mechanisms of abscisic acid perception and signaling
    Karsten Melcher
    Laboratory of Structural Sciences, Van Andel Research Institute, 333 Bostwick Ave N E, Grand Rapids, MI 49503, USA
    Curr Opin Struct Biol 20:722-9. 2010
    ....
  26. doi Synergistic effects of p38 mitogen-activated protein kinase inhibition with a corticosteroid in alveolar macrophages from patients with chronic obstructive pulmonary disease
    J Armstrong
    Medicines Evaluation Unit, National Institute for Health Research Translational Research Facility, University Hospital of South Manchester Foundation Trust, University of Manchester, Manchester, United Kingdom
    J Pharmacol Exp Ther 338:732-40. 2011
    ..Combining a p38 MAPK inhibitor with a corticosteroid synergistically enhances the anti-inflammatory effects on LPS-mediated cytokine production by alveolar macrophages from patients with COPD and controls...
  27. ncbi Neuronal cytoskeleton and synaptic densities are altered after a chronic treatment with the cannabinoid receptor agonist WIN 55,212-2
    Patricia Tagliaferro
    Instituto de Biologia Celular y Neurociencias Prof E De Robertis, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 3 er piso, C1121ABG, Buenos Aires, Argentina
    Brain Res 1085:163-76. 2006
    ....
  28. ncbi Pharmacodynamics of the type II calcimimetic compound cinacalcet HCl
    Edward F Nemeth
    Amgen, Inc, Thousand Oaks, CA 91320 1799, USA
    J Pharmacol Exp Ther 308:627-35. 2004
    ..The present findings provide compelling evidence that cinacalcet HCl is a potent and stereoselective activator of the parathyroid CaR and, as such, might be beneficial in the treatment of hyperparathyroidism...
  29. pmc Selective recognition of pyrimidine-pyrimidine DNA mismatches by distance-constrained macrocyclic bis-intercalators
    Matthias Bahr
    Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D 52056 Aachen, Germany
    Nucleic Acids Res 36:5000-12. 2008
    ..Altogether, our results demonstrate that macrocyclic distance-constrained bis-intercalators are efficient and selective mismatch-binding ligands that can interfere with mismatch-binding enzymes...
  30. ncbi Cinacalcet reduces plasma intact parathyroid hormone, serum phosphate and calcium levels in patients with secondary hyperparathyroidism irrespective of its severity
    J M Frazao
    School of Medicine, Porto University, Porto, Portugal
    Clin Nephrol 76:233-43. 2011
    ..To evaluate the relationship between the severity of secondary hyperparathyroidism (SHPT) - defined in terms of baseline plasma intact parathyroid hormone (iPTH) level - and the magnitude of response to cinacalcet...
  31. doi Study design and subject baseline characteristics in the ADVANCE Study: effects of cinacalcet on vascular calcification in haemodialysis patients
    Jurgen Floege
    Division of Nephrology, RWTH University of Aachen, Aachen, Germany
    Nephrol Dial Transplant 25:1916-23. 2010
    ..We report the ADVANCE Study design and baseline subject characteristics...
  32. pmc Group VIA phospholipase A2 (iPLA2beta) participates in angiotensin II-induced transcriptional up-regulation of regulator of g-protein signaling-2 in vascular smooth muscle cells
    Zhongwen Xie
    Department of Physiology and the Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
    J Biol Chem 282:25278-89. 2007
    ..Collectively, our results demonstrate that iPLA2beta participates in Ang II-induced transcriptional up-regulation of RGS2 in VSMC...
  33. ncbi The effect of chronic peripubertal cannabinoid treatment on deficient object recognition memory in rats after neonatal mPFC lesion
    Miriam Schneider
    Department of Psychiatry and Psychotherapy, University of Cologne, 50924 Cologne, Germany
    Eur Neuropsychopharmacol 17:180-6. 2007
    ..This study shows that behavioral deviations induced by neonatal mPFC lesions can be exacerbated by pubertal chronic cannabinoid treatment, leading to long-lasting impairments of mnemonic short-term information processing...
  34. pmc Apoptosis of insulin-secreting cells induced by endoplasmic reticulum stress is amplified by overexpression of group VIA calcium-independent phospholipase A2 (iPLA2 beta) and suppressed by inhibition of iPLA2 beta
    Sasanka Ramanadham
    Mass Spectrometry Resource, Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Washington University School of Medicine, Box 8127, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Biochemistry 43:918-30. 2004
    ..These findings indicate that iPLA(2)beta participates in ER stress-induced apoptosis, a pathway that promotes beta-cell death in diabetes...
  35. doi Macrocyclic DNA-mismatch-binding ligands: structural determinants of selectivity
    Anton Granzhan
    UMR176 CNRS, Institut Curie, Centre de Recherche, Centre Universitaire, 91405 Orsay, France
    Chemistry 16:878-89. 2010
    ..The study demonstrates that the topology of the ligands plays a crucial role in determining the mismatch-binding affinity and selectivity of the macrocyclic bisintercalators...
  36. doi Post-training CB1 cannabinoid receptor agonist activation disrupts long-term consolidation of spatial memories in the hippocampus
    T T Yim
    Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, Canada T1K 3M4
    Neuroscience 151:929-36. 2008
    ..Plausible pharmacological interactions between cannabinoids and other neurotransmitter systems and associated plasticity mechanisms are discussed...
  37. doi Cyclic stretch-induced stress fiber dynamics - dependence on strain rate, Rho-kinase and MLCK
    Chin Fu Lee
    Department of Biomedical Engineering, Texas A and M University, College Station, TX 77843 3120, United States
    Biochem Biophys Res Commun 401:344-9. 2010
    ..These results shed new light on the mechanism by which stress fibers reorient in response to cyclic stretch in different regions of the actin cytoskeleton...
  38. ncbi Group VIA calcium-independent phospholipase A2 mediates endothelial cell S phase progression
    Shane P Herbert
    Faculty of Biological Sciences, Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biol Chem 281:35709-16. 2006
    ..Consequently, iPLA2-VIA is a novel regulator of endothelial cell S phase progression, cell cycle residence, and angiogenesis...
  39. doi The CB1 receptor agonist, WIN 55,212-2, dose-dependently disrupts object recognition memory in adult rats
    Jean Ha Baek
    Dept of Pharmacology and Toxicology, School of Medical Sciences, University of Otago Medical School, Dunedin, New Zealand
    Neurosci Lett 464:71-3. 2009
    ..These results suggest that WIN can interfere with object recognition memory even in adult rats following a single injection of a low dose...
  40. doi In vitro phase I metabolism of the synthetic cannabimimetic JWH-018
    Annette Wintermeyer
    Institute of Legal Medicine, Medical Faculty, University of Cologne, Melatengürtel 60 62, 50823 Cologne, Germany
    Anal Bioanal Chem 398:2141-53. 2010
    ..N-dealkylation also in combination with both monohydroxylation and dihydrodiol formation of the N-dealkylated metabolite was detected. Finally, a metabolite was found carboxylated at the alkyl side chain...
  41. doi Structure-activity study in the class of 6-(3'-hydroxyphenyl)naphthalenes leading to an optimization of a pharmacophore model for 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitors
    Sandrine Marchais-Oberwinkler
    8 2 Pharmaceutical and Medicinal Chemistry, Saarland University, P O Box 15 11 50, D 66041 Saarbrucken, Germany
    Mol Cell Endocrinol 301:205-11. 2009
    ..Compound 18 also showed a good selectivity toward 17beta-HSD2 and the estrogen receptors alpha and beta...
  42. doi Detection of JWH-018 metabolites in smoking mixture post-administration urine
    Tim Sobolevsky
    Moscow Antidoping Centre, Elizavetinsky per 10, 105005 Moscow, Russia
    Forensic Sci Int 200:141-7. 2010
    ..The parent compound was not detected in urine...
  43. ncbi Cooperative endocannabinoid production by neuronal depolarization and group I metabotropic glutamate receptor activation
    Takako Ohno-Shosaku
    Department of Cellular Neurophysiology, Graduate School of Medical Science, Kanazawa University, Kanazawa 920 8640, Japan
    Eur J Neurosci 15:953-61. 2002
    ..Enhancement of DSI by DHPG was also observed in hippocampal slices. These results suggest that two pathways work in a cooperative manner to release endocannabinoids via a common intracellular cascade...
  44. ncbi Structure-activity relationships of the p38alpha MAP kinase inhibitor 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naph- thalen-1-yl]urea (BIRB 796)
    John Regan
    Department of Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals, Research and Development Center, 900 Ridgebury Road, Ridgefield, Connecticut 06877, USA
    J Med Chem 46:4676-86. 2003
    ..Finally, we describe several compounds that potently inhibit TNF-alpha production when dosed orally in mice...
  45. pmc Physiologically based pharmacokinetic model for terbinafine in rats and humans
    Mahboubeh Hosseini-Yeganeh
    Faculty of Pharmacy, University of Sydney, Sydney, New South Wales 2006, Australia
    Antimicrob Agents Chemother 46:2219-28. 2002
    ....
  46. pmc Myosin light chain kinase is involved in lipopolysaccharide-induced disruption of colonic epithelial barrier and bacterial translocation in rats
    Raphael Moriez
    Institut National de la Recherche Agronomique, Neuro Gastroenterology and Nutrition Unit, 180 chemin de Tournefeuille, BP 3, 31931 Toulouse Cedex 9, France
    Am J Pathol 167:1071-9. 2005
    ..Inhibition of MLCK-dependent colonocyte cytoskeleton contraction by ML-7 prevents the LPS-induced alterations of CPP and its subsequent effects...
  47. ncbi Complete sequence and genetic organization of pDTG1, the 83 kilobase naphthalene degradation plasmid from Pseudomonas putida strain NCIB 9816-4
    Jonathan J Dennis
    Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada, T6G 2E9
    J Mol Biol 341:753-68. 2004
    ....
  48. ncbi Two distinct classes of muscarinic action on hippocampal inhibitory synapses: M2-mediated direct suppression and M1/M3-mediated indirect suppression through endocannabinoid signalling
    Yuko Fukudome
    Department of Cellular Neurophysiology, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8640, Japan
    Eur J Neurosci 19:2682-92. 2004
    ..Thus, the muscarinic system can influence hippocampal functions by controlling different subsets of inhibitory synapses through the two distinct mechanisms...
  49. ncbi Pharmacokinetics, pharmacodynamics, and safety of cinacalcet hydrochloride in hemodialysis patients at doses up to 200 mg once daily
    Robert Z Harris
    Department of Pharmacokinetics and Drug Metabolism, Amgen Inc, Thousand Oaks, CA 91360, USA
    Am J Kidney Dis 44:1070-6. 2004
    ..This study investigated the pharmacokinetics, pharmacodynamics, safety, and tolerability of cinacalcet HCl over a dose range of 25 to 300 mg/d in patients receiving dialysis...
  50. ncbi Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site
    Christopher Pargellis
    Department of Biology, Boehringer Ingelheim Pharmaceuticals, Research and Development Center, 900 Ridgebury Road, Ridgefield, Connecticut 06877, USA
    Nat Struct Biol 9:268-72. 2002
    ..One of the most potent compounds in this series, BIRB 796, has picomolar affinity for the kinase and low nanomolar inhibitory activity in cell culture...
  51. ncbi Tissue distribution of terbinafine in rats
    M Hosseini-Yeganeh
    Faculty of Pharmacy, College of Health Sciences, University of Sydney, Sydney, NSW, 2006, Australia
    J Pharm Sci 90:1817-28. 2001
    ..Uptake of terbinafine into brain (K(p) = 1.3) and muscle (K(p) = 1.0) was significantly lower. In conclusion, terbinafine displays extensive uptake to peripheral tissues, which contributes to the long elimination half-life of this drug...
  52. ncbi Cannabinoids attenuate capsaicin-evoked hyperalgesia through spinal and peripheral mechanisms
    L M Johanek
    Department of Psychiatry, University of Minnesota, 420 Delaware Street SE, Mayo Mail Code 392, Minneapolis, MN 55455, USA
    Pain 93:303-15. 2001
    ..These data show that cannabinoids possess antihyperalgesic properties at doses that alone do not produce antinociception, and are capable of acting at both spinal and peripheral sites...
  53. ncbi Cannabinoid receptor-mediated inhibition of the rat tail-flick reflex after microinjection into the rostral ventromedial medulla
    W J Martin
    Department of Psychology, Brown University, Providence, RI 02912, USA
    Neurosci Lett 242:33-6. 1998
    ..These results demonstrate that the cannabinoid receptor system participates in the descending control of nociception and raise the possibility that actions of endogenous cannabinoids in the RVM may modulate nociceptive responsiveness...
  54. pmc Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson's disease: role of CB(1) and TRPV1 receptors
    Maria Grazia Morgese
    Department of Biomedical Sciences, University of Foggia, Viale Luigi Pinto 1, 71100 Foggia, Italy
    Exp Neurol 208:110-9. 2007
    ..Our data indicate that pharmacological blockade of TRPV1 receptors unmasks the anti-dyskinetic effects of FAAH inhibitors and that CB(1) and TRPV1 receptors play opposite roles in levodopa-induced dyskinesias...
  55. ncbi Role of an endoplasmic reticulum Ca(2+)-independent phospholipase A(2) in oxidant-induced renal cell death
    Brian S Cummings
    Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Physiol Renal Physiol 283:F492-8. 2002
    ..These results are the first to demonstrate the expression and subcellular localization of an ER-iPLA(2). These results also suggest that ER-iPLA(2) functions to protect against oxidant-induced lipid peroxidation and oncosis...
  56. ncbi Ca2+-independent phospholipase A2 enhances store-operated Ca2+ entry in dystrophic skeletal muscle fibers
    François Xavier Boittin
    Laboratory of Pharmacology, Geneva Lausanne School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, 1211 Geneva 4, Switzerland
    J Cell Sci 119:3733-42. 2006
    ..The Ca2+-independent phospholipase A2 pathway therefore appears as an attractive target to reduce excessive Ca2+ influx and subsequent degeneration occurring in dystrophic fibers...
  57. ncbi Studies on the different modes of action of the anticoagulant protease inhibitors DX-9065a and Argatroban. I. Effects on thrombin generation
    Hajime Nagashima
    New Product Research Laboratories II, Daiichi Pharmaceutical Co, Ltd, Tokyo 104 8369, Japan
    J Biol Chem 277:50439-44. 2002
    ..This study demonstrates differential inhibition of thrombin generation by fXa and thrombin inhibitors and has implications for the pharmacological regulation of blood coagulation by the anticoagulant protease inhibitors...
  58. ncbi Suppression by WIN55212-2, a cannabinoid receptor agonist, of inflammatory reactions in mouse ear: Interference with the actions of an endogenous ligand, 2-arachidonoylglycerol
    Saori Oka
    Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Tsukui gun, Kanagawa 199 0195, Japan
    Eur J Pharmacol 538:154-62. 2006
    ..These results suggest that the anti-inflammatory activity of WIN55212-2 is attributable, at least in part, to interference with the actions of the endogenous ligand, 2-arachidonoylglycerol...
  59. doi A randomized, double-blind, placebo-controlled study to assess the efficacy and safety of cinacalcet HCl in participants with CKD not receiving dialysis
    Michel Chonchol
    University of Colorado Health Science Center, Division of Renal Diseases and Hypertension, Denver, CO 80262, USA
    Am J Kidney Dis 53:197-207. 2009
    ..Secondary hyperparathyroidism is observed in patients with early chronic kidney disease (CKD). This study investigated the safety and efficacy of cinacalcet for secondary hyperparathyroidism in participants with CKD not receiving dialysis...
  60. pmc Combined genomic and proteomic approaches identify gene clusters involved in anaerobic 2-methylnaphthalene degradation in the sulfate-reducing enrichment culture N47
    Drazenka Selesi
    Institute of Groundwater Ecology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    J Bacteriol 192:295-306. 2010
    ..The present work provides the first insight into the genetic basis of anaerobic 2-methylnaphthalene metabolism and delivers implications for understanding contaminant degradation...
  61. ncbi Calcium-independent phospholipase A2 modulates cytosolic oxidant activity and contractile function in murine skeletal muscle cells
    Ming C Gong
    Dept of Physiology, Univ of Kentucky Medical Center, 800 Rose St, Lexington, KY 40536, USA
    J Appl Physiol 100:399-405. 2006
    ..These findings suggest that constitutively expressed iPLA2 modulates oxidant activity in skeletal muscle fibers by supporting ROS production, thereby influencing contractile properties and fatigue characteristics...
  62. ncbi Inhibition of interneuron firing extends the spread of endocannabinoid signaling in the cerebellum
    Anatol C Kreitzer
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
    Neuron 34:787-96. 2002
    ..Because interneurons can project over several hundred micrometers, this inhibition of firing allows cells to regulate synaptic inputs at distances well beyond the limits of endocannabinoid diffusion...
  63. doi Behavioural disturbances and altered Fos protein expression in adult rats after chronic pubertal cannabinoid treatment
    Nico Wegener
    Brain Research Institute, Department of Neuropharmacology, University of Bremen, Bremen, Germany
    Brain Res 1253:81-91. 2009
    ....
  64. ncbi Brief trains of action potentials enhance pyramidal neuron excitability via endocannabinoid-mediated suppression of inhibition
    Dale A Fortin
    Dept of Pharmacology, MC 6125, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030, USA
    J Neurophysiol 92:2105-12. 2004
    ..The time course of this effect paralleled DSI expression and was completely blocked by AM251. Taken together, our data suggest a role for endocannabinoids in regulating the output of cortical PNs...
  65. doi Transdermal iontophoretic delivery of terbinafine hydrochloride: quantitation of drug levels in stratum corneum and underlying skin
    Vishal Sachdeva
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Mercer University, Atlanta, GA 30341, United States
    Int J Pharm 388:24-31. 2010
    ..Iontophoresis enhanced the delivery of terbinafine hydrochloride into the skin layers and, therefore, may be used to improve the treatment of skin fungal infections...
  66. doi The utility of naphthyl-keratin adducts as biomarkers for jet-fuel exposure
    Juei Chuan C Kang-Sickel
    Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, USA
    Biomarkers 16:590-9. 2011
    ..Further studies are warranted to characterize the relationship between NKA, other exposure biomarkers, and/or biomarkers of biological effects due to naphthalene and/or PAH exposure...
  67. ncbi Tolerance to the memory disruptive effects of cannabinoids involves adaptation by hippocampal neurons
    Robert E Hampson
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
    Hippocampus 13:543-56. 2003
    ....
  68. ncbi Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration
    Edward K Dziadulewicz
    Novartis Institutes for BioMedical Research, 5 Gower Place, London, United Kingdom
    J Med Chem 50:3851-6. 2007
    ....
  69. ncbi The CB1 cannabinoid receptor is the major cannabinoid receptor at excitatory presynaptic sites in the hippocampus and cerebellum
    Yoshinobu Kawamura
    Department of Cellular Neuroscience, Graduate School of Medicine, Osaka University, Suita 565 0871, Japan
    J Neurosci 26:2991-3001. 2006
    ....
  70. doi Cinacalcet for secondary hyperparathyroidism in children with end-stage renal disease
    Jutta Muscheites
    Department of Pediatrics, University of Rostock, Rostock, Germany
    Pediatr Nephrol 23:1823-9. 2008
    ..Therefore, our results support the initiation of a randomized, controlled, long-term trial in children...
  71. doi Selective lack of tolerance to delayed gastric emptying after daily administration of WIN 55,212-2 in the rat
    R Abalo
    Departamento de Ciencias de la Salud III, Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Madrid, Spain
    Neurogastroenterol Motil 21:1002-e80. 2009
    ..The different systems show differential sensitivity to cannabinoids and tolerance developed at different rates, with delayed gastric emptying being particularly resistant to attenuation upon chronic treatment...
  72. pmc Cannabinoid-induced hyperphagia: correlation with inhibition of proopiomelanocortin neurons?
    Jennie Ho
    Department of Basic Medical Sciences, Western University of Health Sciences, Pomona, CA 91766, United States
    Physiol Behav 92:507-19. 2007
    ..These data demonstrate that cannabinoids regulate appetite in the guinea pig in part through both presynaptic and postsynaptic actions on anorexigenic POMC neurons...
  73. doi Cinacalcet hydrochloride therapy for secondary hyperparathyroidism in hemodialysis patients
    Eid M El-Shafey
    Nephrology Division, Internal Medicine Department Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt
    Ther Apher Dial 15:547-55. 2011
    ..Suppression of iPTH with cinacalcet reverses bone loss in the proximal femur. Cinacalcet alleviated itching...
  74. doi Effect of a synthetic cannabinoid agonist on the proliferation and invasion of gastric cancer cells
    Xiang Shu Xian
    Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
    J Cell Biochem 110:321-32. 2010
    ..Our results open the possibilities in using cannabinoids as a new gastric cancer therapy...
  75. pmc Keratinocyte growth factor protects against Clara cell injury induced by naphthalene
    A O Yildirim
    Clinical Research Group Chronic Airway Diseases, Medical Faculty, Philipps University Marburg, Hans Meerwein Str 1, 35043 Marburg, Germany
    Eur Respir J 32:694-704. 2008
    ..This suggests that N-terminally truncated recombinant human keratinocyte growth factor exerts its beneficial effect through a decrease in the expression of cytochrome P(450) isoform 2F2...
  76. ncbi Myosin light-chain kinase contributes to short-term endothelial cell cytoskeletal alteration induced by serum from burned rats
    Bo Chen
    Department of Pathophysiology, First Military Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 24:481-4, 488. 2004
    ....
  77. doi Metabolites of the mangrove fungus Xylaria sp. BL321 from the South China Sea
    Yong Xiang Song
    School of Chemistry and Chemical Engineering, Sun Yat Sen University, Guangzhou, P R China
    Planta Med 78:172-6. 2012
    ..Compounds 4-7 displayed cytotoxicity against human breast cancer cell lines MCF-7 and MDA-MB-435, while compounds 1- 3 were inactive (IC(50) > 50 µM)...
  78. ncbi Synthesis and cytotoxic evaluation of eremophilane sesquiterpene 07H239-A derivatives
    Yong Xiang Song
    School of Chemistry and Chemical Engineering, Sun Yat Sen University, Guangzhou, P R China
    Chem Pharm Bull (Tokyo) 59:1186-9. 2011
    ....
  79. doi Polychlorinated dibenzo-p-dioxins, dibenzofurans, biphenyls, and naphthalenes in plasma of workers deployed at the World Trade Center after the collapse
    Yuichi Horii
    Center for Environmental Science in Saitama, Kazo, Saitama 347 0115, Japan
    Environ Sci Technol 44:5188-94. 2010
    ..PCDDs), polychlorinated dibenzofurans (PCDFs), polychlorinated biphenyls (PCBs), and polychlorinated naphthalenes (PCNs)...
  80. ncbi Cannabinoids blocks tactile allodynia in diabetic mice without attenuation of its antinociceptive effect
    Ahmet Dogrul
    Department of Pharmacology, Gülhane Academy of Medicine, 06018 Etlik, Ankara, Turkey
    Neurosci Lett 368:82-6. 2004
    ..WIN 55, 212-2 also produced a dose-dependent antiallodynic effect in diabetic mice. This study suggests that cannabinoids have a potential beneficial effect on experimental diabetic neuropathic pain...
  81. pmc Antinociceptive effect of cannabinoid agonist WIN 55,212-2 in rats with a spinal cord injury
    Aldric Hama
    University of Miami Miller School of Medicine, The Miami Project to Cure Paralysis, 1095 NW 14th Terrace R 48, Miami, FL 33136, USA
    Exp Neurol 204:454-7. 2007
    ..These data indicate that a CB(1)-selective agonist may be novel therapeutic treatment for clinical SCI pain...
  82. doi Red yeast rice increases excretion of bile acids in hamsters
    Ka Ying Ma
    Food and Nutritional Sciences Program, Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Biomed Environ Sci 22:269-77. 2009
    ..To investigate the hypocholesterolemic activity of red yeast rice (RYR) and its underlying mechanism...
  83. ncbi Cannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphoma
    Jenny Flygare
    Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet, Karolinska University Hospital Huddinge, F 46, SE 141 86 Stockholm, Sweden
    FEBS Lett 579:6885-9. 2005
    ..Induction of apoptosis, as measured by FACS/Annexin V-FITC, contributed to the growth suppressive effect of Win-55,212-2. Our data suggest that cannabinoid receptors may be considered as potential therapeutic targets in MCL...
  84. ncbi Ancisheynine, the first n,c-coupled naphthylisoquinoline alkaloid: total synthesis and stereochemical analysis
    Gerhard Bringmann
    Institute of Organic Chemistry, University of Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    Org Lett 8:1037-40. 2006
    ..The assignment of their axial configurations succeeded by quantum chemical CD calculations...
  85. pmc Effects of Delta9-tetrahydrocannabivarin on [35S]GTPgammaS binding in mouse brain cerebellum and piriform cortex membranes
    I Dennis
    School of Pharmacy, University of Reading, Whiteknights, Reading, UK
    Br J Pharmacol 154:1349-58. 2008
    ..Here, we investigate the mode of cannabinoid action in [35S]GTPgammaS binding assays...
  86. doi Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes
    Donald A Patrick
    Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Eur J Med Chem 44:3543-51. 2009
    ..3 microM). Compound 2 displayed the greatest activity against T. b. rhodesiense in vivo, curing three of four infected mice dosed intraperitoneally at 5 mg/kg x 4 days...
  87. pmc Prolonged exposure to WIN55,212-2 causes downregulation of the CB1 receptor and the development of tolerance to its anticonvulsant effects in the hippocampal neuronal culture model of acquired epilepsy
    Robert E Blair
    Department of Neurology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Neuropharmacology 57:208-18. 2009
    ....
  88. doi Supraspinal role of protein kinase C in oxaliplatin-induced neuropathy in rat
    M Norcini
    Department of Clinical and Preclinical Pharmacology, University of Florence, Italy
    Pain 146:141-7. 2009
    ....
  89. pmc Late-postnatal cannabinoid exposure persistently increases FoxP2 expression within zebra finch striatum
    Ken Soderstrom
    Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, North Carolina 27834, USA
    Dev Neurobiol 70:195-203. 2010
    ..Thus, song-altering cannabinoid treatments are associated with persistent increases in basal expression of FoxP2 in zebra finch striatum...
  90. doi Factors influencing trends of polychlorinated naphthalenes and other dioxin-like compounds in lake trout (Salvelinus namaycush) from Lake Ontario, North America (1979-2004)
    Sarah B Gewurtz
    Department of Chemistry, Brock University, 500 Glenridge Avenue, St Catharines, Ontario L2S 3A1, Canada
    Environ Toxicol Chem 28:921-30. 2009
    Concentrations of polychlorinated naphthalenes (PCNs) were determined in archived lake trout (Salvelinus namaycush) from Lake Ontario, North America, collected between 1979 and 2004 to evaluate their temporal trends and the factors ..
  91. ncbi First experience with direct, selective factor Xa inhibition in patients with non-ST-elevation acute coronary syndromes: results of the XaNADU-ACS Trial
    J H Alexander
    Duke University Center and Duke Clinical Research Institute, Durham, NC 27715, USA
    J Thromb Haemost 3:439-47. 2005
    ..Anticoagulants with predictable kinetics and anticoagulant effects, better efficacy, and greater safety are needed...
  92. pmc CB(1) cannabinoid receptor activation dose dependently modulates neuronal activity within caudal but not rostral song control regions of adult zebra finch telencephalon
    Ken Soderstrom
    Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
    Psychopharmacology (Berl) 199:265-73. 2008
    ..It is becoming clear that CB(1)-receptor-mediated signaling is important to normal processes of vocal development...
  93. pmc JWH018, a common constituent of 'Spice' herbal blends, is a potent and efficacious cannabinoid CB receptor agonist
    Brady K Atwood
    The Gill Center and the Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA
    Br J Pharmacol 160:585-93. 2010
    ..Other effects of JWH018 on CB(1) receptor-mediated signalling are not known, particularly in neurons. Here we have evaluated the signalling pathways activated by JWH018 at CB(1) receptors...
  94. ncbi Synthetic selective inhibitors of coagulation factor Xa strongly inhibit thrombin generation without affecting initial thrombin forming time necessary for platelet activation in hemostasis
    M Ieko
    Departments of Internal Medicine, Health Sciences University of Hokkaido, Ishikari Tobetsu, Hokkaido, Japan
    J Thromb Haemost 2:612-8. 2004
    ....
  95. ncbi Naphthalene exposure: effects on gene expression and proliferation in human cord blood cells
    Cristina Diodovich
    Laboratory of Hematotoxicology, ECVAM, Institute for Health and Consumer Protection, J R C, 21020 Ispra, Italy
    J Biochem Mol Toxicol 17:286-94. 2003
    ..Furthermore, macroarray analysis showed that naphthalene modified cord blood gene expression, inducing IL-8 precursor and T-cell transcription factor and decreasing the level of RNA-binding protein FUS/TLS...
  96. ncbi Upregulation of spinal cannabinoid-1-receptors following nerve injury enhances the effects of Win 55,212-2 on neuropathic pain behaviors in rats
    Grewo Lim
    Department of Anesthesia and Critical Care, MGH Pain Center, WACC 324, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA 02114, USA
    Pain 105:275-83. 2003
    ..These results indicate that upregulation of spinal CB1Rs following peripheral nerve injury may contribute to the therapeutic effects of exogenous cannabinoids on neuropathic pain...
  97. ncbi 'Knock-down' of spinal CB1 receptors produces abnormal pain and elevates spinal dynorphin content in mice
    Ahmet Dogrul
    Department of Pharmacology, School of Medicine, Gulhane Military Medical Academy, 06018, Etlik, Ankara, Turkey
    Pain 100:203-9. 2002
    ....
  98. doi Rationale and design of a randomized, double-blind, parallel-group study of terutroban 30 mg/day versus aspirin 100 mg/day in stroke patients: the prevention of cerebrovascular and cardiovascular events of ischemic origin with terutroban in patients with
    M G Bousser
    Hôpital Lariboisière AP HP, INSERM U 740, Paris, France
    Cerebrovasc Dis 27:509-18. 2009
    ....
  99. ncbi Cannabinoid exposure alters learning of zebra finch vocal patterns
    Ken Soderstrom
    Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
    Brain Res Dev Brain Res 142:215-7. 2003
    ..Adult exposure did not change song that had already been learned. Our results demonstrate the potential for cannabinoid exposure to produce distinct effects during post-natal CNS development...
  100. ncbi DX-9065a inhibition of factor Xa and the prothrombinase complex: mechanism of inhibition and comparison with therapeutic heparins
    Alireza R Rezaie
    Edward A Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, St Louis, Missouri, USA
    Thromb Haemost 89:112-21. 2003
    ..Further studies revealed that Tyr(99), a residue in the extended S2-S4 binding pocket of fXa, plays a key role in determination of specificity of the DX-9065a interaction...
  101. ncbi Activation of cannabinoid receptors in rat brain by WIN 55212-2 produces coupling to multiple G protein alpha-subunits with different potencies
    P L Prather
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Mol Pharmacol 57:1000-10. 2000
    ....

Research Grants157 found, 100 shown here

  1. LUNG INJURY BY NAPHTHALENES
    Alan Buckpitt; Fiscal Year: 2009
    ..Human exposure to naphthalenes occurs from a variety of sources including cigarette smoke and polluted air...
  2. LUNG INJURY BY NAPHTHALENES
    Alan Buckpitt; Fiscal Year: 1993
    ..These studies will provide a better basis for assessing risk of human exposure to naphthalene/2-methylnaphthalene and will result in methods that are applicable for assessing hazards of other pneumotoxic chemicals...
  3. LUNG INJURY BY NAPHTHALENES
    Alan Buckpitt; Fiscal Year: 2004
    ..One class of these toxic chemicals, the naphthalenes, are potentially important both because they result in a well defined injury to bronchiolar epithelial cells ..
  4. Treatment of Cannabinoid Withdrawal in Rhesus Monkeys
    LANCE MCMAHON; Fiscal Year: 2007
    ..abstract_text> ..
  5. Nicotine dependence: neuropharmacology in monkeys
    Lance R McMahon; Fiscal Year: 2010
    ..This grant investigates the receptor pharmacology of currently approved medications for smoking cessation and could lead to better treatment, thereby decreasing the devastating health consequence of tobacco use. ..
  6. Drug discrimination and THC withdrawal in monkeys
    LANCE MCMAHON; Fiscal Year: 2005
    ..abstract_text> ..
  7. Pharmacotherapy of Cannabinoid Withdrawal: Pre-Clinical Studies
    Lance R McMahon; Fiscal Year: 2010
    ..Collectively, these specific aims provide a framework for developing novel pharmacotherapies of marijuana withdrawal that could markedly decrease marijuana use and dependence. ..
  8. Treatment of Cannabinoid Withdrawal in Rhesus Monkeys
    Lance R McMahon; Fiscal Year: 2010
    ..This competing continuation addresses a need to understand mechanisms at cannabinoid receptors that mediate the dependence liability of marijuana and the potential therapeutic utility of the cannabinoids. ..
  9. Cannabinoid Regulation of Basal Ganglia Glutamate and GABA
    SCOTT RAWLS; Fiscal Year: 2007
    ..Our outcomes will be a first step in determining whether blocking endocannabinoid inactivation offers any therapeutic advantage over direct activation of cannabinoid receptors with marijuana. ..
  10. EXOGENOUS AND ENDOGENOUS CANNABINOIDS--A COMPARISON
    TORBJORN JARBE; Fiscal Year: 2000
    ....
  11. PRIMARY HYPERPARATHYROIDISM: NON-CLASSICAL MANIFESTATIONS
    Shonni Silverberg; Fiscal Year: 2009
    ..abstract_text> ..
  12. Vitamin D Deficiency in Primary Hyperparathyroidism
    Shonni J Silverberg; Fiscal Year: 2010
    ....
  13. Non-Classical Manifestations of Primary Hyperparathyroidism
    Shonni Silverberg; Fiscal Year: 2007
    ....
  14. Synthesis of Bioactive Alkaloids and Peptides
    David A Evans; Fiscal Year: 2010
    ..Consequently, organic synthesis is a critical discipline that continues to have a pivotal impact on the fields of both medicine and biology. This grant will focus on the synthesis of bioactive alkaloids and peptides. ..
  15. Exogenous/endogenous cannabinoids--A comparison
    TORBJORN JARBE; Fiscal Year: 2006
    ....
  16. Synthesis of Polyketides and Terpenes
    David A Evans; Fiscal Year: 2010
    ..As a consequence, organic synthesis is a critical discipline that continues to have an important impact on the fields of both medicine and biology. ..
  17. Synthesis of Polyketides and Terpenes
    David Evans; Fiscal Year: 2007
    ..As a consequence, organic synthesis is a critical discipline that continues to have an important impact on the fields of both medicine and biology. ..
  18. Endogenous/exogenous cannabinoids: A comparison
    TORBJORN U JARBE; Fiscal Year: 2010
    ....
  19. DIURNAL AND PULSATILE PTH SECRETION IN RENAL FAILURE
    William Goodman; Fiscal Year: 2001
    ....
  20. ASYMMETRIC SYNTHESIS OF IONOPHORE/MACROLIDE ANTIBIOTICS
    David Evans; Fiscal Year: 1999
    ..The goal of these studies will be to reveal some of the general rules for predicting the stereochemical outcome of complex aldol fragment coupling reactions. ..
  21. ASYMMETRIC SYNTHESIS OF IONOPHORE & MACROLIDE ANTIBIOTIC
    David Evans; Fiscal Year: 1993
    ....
  22. ASYMMETRIC SYNTHESIS OF VANCOMYCIN ANTIBIOTICS
    David Evans; Fiscal Year: 1993
    ..During the course of this project we intend to confirm (correct) the absolute stereochemical assignment of the principal members of this family by total synthesis...
  23. Leptin Action and Resistance in POMC-Neurons
    SHANE HENTGES; Fiscal Year: 2005
    ..abstract_text> ..
  24. Joint Action Analysis of Poly-drug Withdrawal
    Robert Raffa; Fiscal Year: 2006
    ..g., electrophysiologic or molecular biology techniques. An improved understanding of how withdrawal is influenced by poly-drug abuse could lead to development of enhanced clinical treatment. ..
  25. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 2003
    ....
  26. HISTAMINERGIC MECHANISMS OF ANALGESIA
    LINDSAY HOUGH; Fiscal Year: 1992
    ..These studies will enhance our knowledge of antinociceptive mechanisms, and may lead to the development of novel, clinically useful agents for the relief of pain...