naphthalenes

Summary

Summary: Two-ring crystalline hydrocarbons isolated from coal tar. They are used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, preservatives, and, formerly, as topical antiseptics.

Top Publications

  1. ncbi Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes
    Birgit Heltweg
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 66:4368-77. 2006
  2. ncbi Effects of cinacalcet and concurrent low-dose vitamin D on FGF23 levels in ESRD
    James B Wetmore
    University of Kansas Medical Center, MS 3002, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Clin J Am Soc Nephrol 5:110-6. 2010
  3. ncbi Calcium-independent phospholipase A2 modulates cytosolic oxidant activity and contractile function in murine skeletal muscle cells
    Ming C Gong
    Dept. of Physiology, Univ. of Kentucky Medical Center, 800 Rose St, Lexington, KY 40536, USA
    J Appl Physiol 100:399-405. 2006
  4. ncbi Opposing actions of chronic Delta9-tetrahydrocannabinol and cannabinoid antagonists on hippocampal long-term potentiation
    Alexander F Hoffman
    United States Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, Cellular Neurobiology Branch, Electrophysiology Research Unit, Baltimore, Maryland 21224, USA
    Learn Mem 14:63-74. 2007
  5. ncbi Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammalian iPL
    Christopher M Jenkins
    Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 277:32807-14. 2002
  6. ncbi CB1 cannabinoid receptors mediate anxiolytic effects: convergent genetic and pharmacological evidence with CB1-specific agents
    J Haller
    Institute of Experimental Medicine, Budapest, Hungary
    Behav Pharmacol 15:299-304. 2004
  7. ncbi Correlated species differences in the effects of cannabinoid ligands on anxiety and on GABAergic and glutamatergic synaptic transmission
    J Haller
    Institute of Experimental Medicine, Department of Behavioral Neurobiology, 1450 Budapest, PO Box 67, Hungary
    Eur J Neurosci 25:2445-56. 2007
  8. ncbi Posttraining activation of CB1 cannabinoid receptors in the CA1 region of the dorsal hippocampus impairs object recognition long-term memory
    Julia R Clarke
    Centro de Memoria, Instituto de Pesquisas Biomédicas, Pontificia Universidade Catolica do Rio Grande do Sul, Av Ipiranga 6690, RS 90610 000 Porto Alegre, Brazil
    Neurobiol Learn Mem 90:374-81. 2008
  9. ncbi Group VIA calcium-independent phospholipase A2 mediates endothelial cell S phase progression
    Shane P Herbert
    Faculty of Biological Sciences, Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biol Chem 281:35709-16. 2006
  10. ncbi Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesis
    Yannick Marchalant
    Department of Psychology, The Ohio State University, Columbus, 43210, USA
    Neurobiol Dis 34:300-7. 2009

Research Grants

  1. LUNG INJURY BY NAPHTHALENES
    Alan Buckpitt; Fiscal Year: 2009
  2. LUNG INJURY BY NAPHTHALENES
    Alan Buckpitt; Fiscal Year: 1993
  3. LUNG INJURY BY NAPHTHALENES
    Alan Buckpitt; Fiscal Year: 2004
  4. Treatment of Cannabinoid Withdrawal in Rhesus Monkeys
    LANCE MCMAHON; Fiscal Year: 2007
  5. Drug discrimination and THC withdrawal in monkeys
    LANCE MCMAHON; Fiscal Year: 2005
  6. Nicotine dependence: neuropharmacology in monkeys
    Lance R McMahon; Fiscal Year: 2010
  7. Treatment of Cannabinoid Withdrawal in Rhesus Monkeys
    Lance R McMahon; Fiscal Year: 2010
  8. Pharmacotherapy of Cannabinoid Withdrawal: Pre-Clinical Studies
    Lance R McMahon; Fiscal Year: 2010
  9. Cannabinoid Regulation of Basal Ganglia Glutamate and GABA
    SCOTT RAWLS; Fiscal Year: 2007
  10. Synthesis of Bioactive Alkaloids and Peptides
    David A Evans; Fiscal Year: 2010

Detail Information

Publications218 found, 100 shown here

  1. ncbi Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes
    Birgit Heltweg
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 66:4368-77. 2006
    ..Cambinol was well tolerated in mice and inhibited growth of Burkitt lymphoma xenografts. Inhibitors of NAD-dependent deacetylases may constitute novel anticancer agents...
  2. ncbi Effects of cinacalcet and concurrent low-dose vitamin D on FGF23 levels in ESRD
    James B Wetmore
    University of Kansas Medical Center, MS 3002, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Clin J Am Soc Nephrol 5:110-6. 2010
    ..The effects of various treatments for secondary hyperparathyroidism on FGF23 levels in ESRD have not been examined in a clinical trial...
  3. ncbi Calcium-independent phospholipase A2 modulates cytosolic oxidant activity and contractile function in murine skeletal muscle cells
    Ming C Gong
    Dept. of Physiology, Univ. of Kentucky Medical Center, 800 Rose St, Lexington, KY 40536, USA
    J Appl Physiol 100:399-405. 2006
    ..These findings suggest that constitutively expressed iPLA2 modulates oxidant activity in skeletal muscle fibers by supporting ROS production, thereby influencing contractile properties and fatigue characteristics...
  4. ncbi Opposing actions of chronic Delta9-tetrahydrocannabinol and cannabinoid antagonists on hippocampal long-term potentiation
    Alexander F Hoffman
    United States Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, Cellular Neurobiology Branch, Electrophysiology Research Unit, Baltimore, Maryland 21224, USA
    Learn Mem 14:63-74. 2007
    ..These data define consequences of repeated Delta(9)-THC exposure for synaptic plasticity in the hippocampus that may help explain memory impairments in humans following chronic marijuana use...
  5. ncbi Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammalian iPL
    Christopher M Jenkins
    Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 277:32807-14. 2002
    ....
  6. ncbi CB1 cannabinoid receptors mediate anxiolytic effects: convergent genetic and pharmacological evidence with CB1-specific agents
    J Haller
    Institute of Experimental Medicine, Budapest, Hungary
    Behav Pharmacol 15:299-304. 2004
    ..This suggests that agonists of the former, or antagonists of the latter, are promising new compounds in the pharmacotherapy of anxiety...
  7. ncbi Correlated species differences in the effects of cannabinoid ligands on anxiety and on GABAergic and glutamatergic synaptic transmission
    J Haller
    Institute of Experimental Medicine, Department of Behavioral Neurobiology, 1450 Budapest, PO Box 67, Hungary
    Eur J Neurosci 25:2445-56. 2007
    ..We suggest that the anxiety-related effects of cannabinoids depend on the relative cannabinoid responsiveness of GABAergic and glutamatergic neurotransmission...
  8. ncbi Posttraining activation of CB1 cannabinoid receptors in the CA1 region of the dorsal hippocampus impairs object recognition long-term memory
    Julia R Clarke
    Centro de Memoria, Instituto de Pesquisas Biomédicas, Pontificia Universidade Catolica do Rio Grande do Sul, Av Ipiranga 6690, RS 90610 000 Porto Alegre, Brazil
    Neurobiol Learn Mem 90:374-81. 2008
    ..Our data indicate that activation of hippocampal CB1 receptors early after training hampers consolidation of object recognition memory...
  9. ncbi Group VIA calcium-independent phospholipase A2 mediates endothelial cell S phase progression
    Shane P Herbert
    Faculty of Biological Sciences, Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biol Chem 281:35709-16. 2006
    ..Consequently, iPLA2-VIA is a novel regulator of endothelial cell S phase progression, cell cycle residence, and angiogenesis...
  10. ncbi Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesis
    Yannick Marchalant
    Department of Psychology, The Ohio State University, Columbus, 43210, USA
    Neurobiol Dis 34:300-7. 2009
    ..Our results provide insight into the role of the endocannabinoid and vanilloid systems upon two different and detrimental aspects of normal and pathological aging, chronic neuroinflammation and decline in neurogenesis...
  11. ncbi Post-training CB1 cannabinoid receptor agonist activation disrupts long-term consolidation of spatial memories in the hippocampus
    T T Yim
    Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, Canada T1K 3M4
    Neuroscience 151:929-36. 2008
    ..Plausible pharmacological interactions between cannabinoids and other neurotransmitter systems and associated plasticity mechanisms are discussed...
  12. ncbi The CB1 receptor agonist, WIN 55,212-2, dose-dependently disrupts object recognition memory in adult rats
    Jean Ha Baek
    Dept of Pharmacology and Toxicology, School of Medical Sciences, University of Otago Medical School, Dunedin, New Zealand
    Neurosci Lett 464:71-3. 2009
    ..These results suggest that WIN can interfere with object recognition memory even in adult rats following a single injection of a low dose...
  13. ncbi Cyclic stretch-induced stress fiber dynamics - dependence on strain rate, Rho-kinase and MLCK
    Chin Fu Lee
    Department of Biomedical Engineering, Texas A and M University, College Station, TX 77843 3120, United States
    Biochem Biophys Res Commun 401:344-9. 2010
    ..These results shed new light on the mechanism by which stress fibers reorient in response to cyclic stretch in different regions of the actin cytoskeleton...
  14. ncbi Structure-activity study in the class of 6-(3'-hydroxyphenyl)naphthalenes leading to an optimization of a pharmacophore model for 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitors
    Sandrine Marchais-Oberwinkler
    8 2 Pharmaceutical and Medicinal Chemistry, Saarland University, P O Box 15 11 50, D 66041 Saarbrucken, Germany
    Mol Cell Endocrinol 301:205-11. 2009
    ..Compound 18 also showed a good selectivity toward 17beta-HSD2 and the estrogen receptors alpha and beta...
  15. ncbi Detection of JWH-018 metabolites in smoking mixture post-administration urine
    Tim Sobolevsky
    Moscow Antidoping Centre, Elizavetinsky per 10, 105005 Moscow, Russia
    Forensic Sci Int 200:141-7. 2010
    ..The parent compound was not detected in urine...
  16. ncbi In vitro phase I metabolism of the synthetic cannabimimetic JWH-018
    Annette Wintermeyer
    Institute of Legal Medicine, Medical Faculty, University of Cologne, Melatengürtel 60 62, 50823 Cologne, Germany
    Anal Bioanal Chem 398:2141-53. 2010
    ..N-dealkylation also in combination with both monohydroxylation and dihydrodiol formation of the N-dealkylated metabolite was detected. Finally, a metabolite was found carboxylated at the alkyl side chain...
  17. ncbi Role of an endoplasmic reticulum Ca(2+)-independent phospholipase A(2) in oxidant-induced renal cell death
    Brian S Cummings
    Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Physiol Renal Physiol 283:F492-8. 2002
    ..These results are the first to demonstrate the expression and subcellular localization of an ER-iPLA(2). These results also suggest that ER-iPLA(2) functions to protect against oxidant-induced lipid peroxidation and oncosis...
  18. ncbi Tolerance to the memory disruptive effects of cannabinoids involves adaptation by hippocampal neurons
    Robert E Hampson
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
    Hippocampus 13:543-56. 2003
    ....
  19. ncbi Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson's disease: role of CB(1) and TRPV1 receptors
    Maria Grazia Morgese
    Department of Biomedical Sciences, University of Foggia, Viale Luigi Pinto 1, 71100 Foggia, Italy
    Exp Neurol 208:110-9. 2007
    ..Our data indicate that pharmacological blockade of TRPV1 receptors unmasks the anti-dyskinetic effects of FAAH inhibitors and that CB(1) and TRPV1 receptors play opposite roles in levodopa-induced dyskinesias...
  20. ncbi Ca2+-independent phospholipase A2 enhances store-operated Ca2+ entry in dystrophic skeletal muscle fibers
    François Xavier Boittin
    Laboratory of Pharmacology, Geneva Lausanne School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, 1211 Geneva 4, Switzerland
    J Cell Sci 119:3733-42. 2006
    ..The Ca2+-independent phospholipase A2 pathway therefore appears as an attractive target to reduce excessive Ca2+ influx and subsequent degeneration occurring in dystrophic fibers...
  21. ncbi Studies on the different modes of action of the anticoagulant protease inhibitors DX-9065a and Argatroban. I. Effects on thrombin generation
    Hajime Nagashima
    New Product Research Laboratories II, Daiichi Pharmaceutical Co, Ltd, Tokyo 104 8369, Japan
    J Biol Chem 277:50439-44. 2002
    ..This study demonstrates differential inhibition of thrombin generation by fXa and thrombin inhibitors and has implications for the pharmacological regulation of blood coagulation by the anticoagulant protease inhibitors...
  22. ncbi The CB1 cannabinoid receptor is the major cannabinoid receptor at excitatory presynaptic sites in the hippocampus and cerebellum
    Yoshinobu Kawamura
    Department of Cellular Neuroscience, Graduate School of Medicine, Osaka University, Suita 565 0871, Japan
    J Neurosci 26:2991-3001. 2006
    ....
  23. ncbi Apoptosis of insulin-secreting cells induced by endoplasmic reticulum stress is amplified by overexpression of group VIA calcium-independent phospholipase A2 (iPLA2 beta) and suppressed by inhibition of iPLA2 beta
    Sasanka Ramanadham
    Mass Spectrometry Resource, Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Washington University School of Medicine, Box 8127, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Biochemistry 43:918-30. 2004
    ..These findings indicate that iPLA(2)beta participates in ER stress-induced apoptosis, a pathway that promotes beta-cell death in diabetes...
  24. ncbi Keratinocyte growth factor protects against Clara cell injury induced by naphthalene
    A O Yildirim
    Clinical Research Group Chronic Airway Diseases, Medical Faculty, Philipps University Marburg, Hans Meerwein Str 1, 35043 Marburg, Germany
    Eur Respir J 32:694-704. 2008
    ..This suggests that N-terminally truncated recombinant human keratinocyte growth factor exerts its beneficial effect through a decrease in the expression of cytochrome P(450) isoform 2F2...
  25. ncbi Selective recognition of pyrimidine-pyrimidine DNA mismatches by distance-constrained macrocyclic bis-intercalators
    Matthias Bahr
    Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D 52056 Aachen, Germany
    Nucleic Acids Res 36:5000-12. 2008
    ..Altogether, our results demonstrate that macrocyclic distance-constrained bis-intercalators are efficient and selective mismatch-binding ligands that can interfere with mismatch-binding enzymes...
  26. ncbi Macrocyclic DNA-mismatch-binding ligands: structural determinants of selectivity
    Anton Granzhan
    UMR176 CNRS, Institut Curie, Centre de Recherche, Centre Universitaire, 91405 Orsay, France
    Chemistry 16:878-89. 2010
    ..The study demonstrates that the topology of the ligands plays a crucial role in determining the mismatch-binding affinity and selectivity of the macrocyclic bisintercalators...
  27. ncbi Polychlorinated dibenzo-p-dioxins, dibenzofurans, biphenyls, and naphthalenes in plasma of workers deployed at the World Trade Center after the collapse
    Yuichi Horii
    Center for Environmental Science in Saitama, Kazo, Saitama 347 0115, Japan
    Environ Sci Technol 44:5188-94. 2010
    ..PCDDs), polychlorinated dibenzofurans (PCDFs), polychlorinated biphenyls (PCBs), and polychlorinated naphthalenes (PCNs)...
  28. ncbi Red yeast rice increases excretion of bile acids in hamsters
    Ka Ying Ma
    Food and Nutritional Sciences Program, Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Biomed Environ Sci 22:269-77. 2009
    ..To investigate the hypocholesterolemic activity of red yeast rice (RYR) and its underlying mechanism...
  29. ncbi Myosin light-chain kinase contributes to short-term endothelial cell cytoskeletal alteration induced by serum from burned rats
    Bo Chen
    Department of Pathophysiology, First Military Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 24:481-4, 488. 2004
    ..CONCLUSION: Serum from burned rats induces characteristic morphological changes in the endothelial cell actin cytoskeleton mainly due to the MLCK activation, an effect that can be reversed by the inhibition of MLCK...
  30. ncbi Antinociceptive effect of cannabinoid agonist WIN 55,212-2 in rats with a spinal cord injury
    Aldric Hama
    University of Miami Miller School of Medicine, The Miami Project to Cure Paralysis, 1095 NW 14th Terrace R 48, Miami, FL 33136, USA
    Exp Neurol 204:454-7. 2007
    ..These data indicate that a CB(1)-selective agonist may be novel therapeutic treatment for clinical SCI pain...
  31. ncbi Functional mechanism of the abscisic acid agonist pyrabactin
    Qi Hao
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China
    J Biol Chem 285:28946-52. 2010
    ..The study provides a framework for the development of novel ABA agonists that may have applicable potentials in agriculture...
  32. ncbi Ancisheynine, the first n,c-coupled naphthylisoquinoline alkaloid: total synthesis and stereochemical analysis
    Gerhard Bringmann
    Institute of Organic Chemistry, University of Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    Org Lett 8:1037-40. 2006
    ..The assignment of their axial configurations succeeded by quantum chemical CD calculations...
  33. ncbi Cannabinoids blocks tactile allodynia in diabetic mice without attenuation of its antinociceptive effect
    Ahmet Dogrul
    Department of Pharmacology, Gülhane Academy of Medicine, 06018 Etlik, Ankara, Turkey
    Neurosci Lett 368:82-6. 2004
    ..WIN 55, 212-2 also produced a dose-dependent antiallodynic effect in diabetic mice. This study suggests that cannabinoids have a potential beneficial effect on experimental diabetic neuropathic pain...
  34. ncbi Metabolites of the mangrove fungus Xylaria sp. BL321 from the South China Sea
    Yong Xiang Song
    School of Chemistry and Chemical Engineering, Sun Yat Sen University, Guangzhou, P R China
    Planta Med 78:172-6. 2012
    ..Compounds 4-7 displayed cytotoxicity against human breast cancer cell lines MCF-7 and MDA-MB-435, while compounds 1- 3 were inactive (IC(50) > 50 µM)...
  35. ncbi Thirsty plants and beyond: structural mechanisms of abscisic acid perception and signaling
    Karsten Melcher
    Laboratory of Structural Sciences, Van Andel Research Institute, 333 Bostwick Ave N E, Grand Rapids, MI 49503, USA
    Curr Opin Struct Biol 20:722-9. 2010
    ....
  36. ncbi Synthesis and cytotoxic evaluation of eremophilane sesquiterpene 07H239-A derivatives
    Yong Xiang Song
    School of Chemistry and Chemical Engineering, Sun Yat Sen University, Guangzhou, P R China
    Chem Pharm Bull (Tokyo) 59:1186-9. 2011
    ....
  37. ncbi Cannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphoma
    Jenny Flygare
    Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet, Karolinska University Hospital Huddinge, F-46, SE-141 86 Stockholm, Sweden
    FEBS Lett 579:6885-9. 2005
    ..Induction of apoptosis, as measured by FACS/Annexin V-FITC, contributed to the growth suppressive effect of Win-55,212-2. Our data suggest that cannabinoid receptors may be considered as potential therapeutic targets in MCL...
  38. ncbi First experience with direct, selective factor Xa inhibition in patients with non-ST-elevation acute coronary syndromes: results of the XaNADU-ACS Trial
    J H Alexander
    Duke University Center and Duke Clinical Research Institute, Durham, NC 27715, USA
    J Thromb Haemost 3:439-47. 2005
    ..Anticoagulants with predictable kinetics and anticoagulant effects, better efficacy, and greater safety are needed...
  39. ncbi Late-postnatal cannabinoid exposure persistently increases FoxP2 expression within zebra finch striatum
    Ken Soderstrom
    Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, North Carolina 27834, USA
    Dev Neurobiol 70:195-203. 2010
    ..Thus, song-altering cannabinoid treatments are associated with persistent increases in basal expression of FoxP2 in zebra finch striatum...
  40. ncbi Effects of Delta9-tetrahydrocannabivarin on [35S]GTPgammaS binding in mouse brain cerebellum and piriform cortex membranes
    I Dennis
    School of Pharmacy, University of Reading, Whiteknights, Reading, UK
    Br J Pharmacol 154:1349-58. 2008
    ..Here, we investigate the mode of cannabinoid action in [35S]GTPgammaS binding assays...
  41. ncbi JWH018, a common constituent of 'Spice' herbal blends, is a potent and efficacious cannabinoid CB receptor agonist
    Brady K Atwood
    The Gill Center and the Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA
    Br J Pharmacol 160:585-93. 2010
    ..Other effects of JWH018 on CB(1) receptor-mediated signalling are not known, particularly in neurons. Here we have evaluated the signalling pathways activated by JWH018 at CB(1) receptors...
  42. ncbi CB(1) cannabinoid receptor activation dose dependently modulates neuronal activity within caudal but not rostral song control regions of adult zebra finch telencephalon
    Ken Soderstrom
    Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
    Psychopharmacology (Berl) 199:265-73. 2008
    ..It is becoming clear that CB(1)-receptor-mediated signaling is important to normal processes of vocal development...
  43. ncbi Supraspinal role of protein kinase C in oxaliplatin-induced neuropathy in rat
    M Norcini
    Department of Clinical and Preclinical Pharmacology, University of Florence, Italy
    Pain 146:141-7. 2009
    ....
  44. ncbi Prolonged exposure to WIN55,212-2 causes downregulation of the CB1 receptor and the development of tolerance to its anticonvulsant effects in the hippocampal neuronal culture model of acquired epilepsy
    Robert E Blair
    Department of Neurology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Neuropharmacology 57:208-18. 2009
    ....
  45. ncbi Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes
    Donald A Patrick
    Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Eur J Med Chem 44:3543-51. 2009
    ..3 microM). Compound 2 displayed the greatest activity against T. b. rhodesiense in vivo, curing three of four infected mice dosed intraperitoneally at 5 mg/kg x 4 days...
  46. ncbi Factors influencing trends of polychlorinated naphthalenes and other dioxin-like compounds in lake trout (Salvelinus namaycush) from Lake Ontario, North America (1979-2004)
    Sarah B Gewurtz
    Department of Chemistry, Brock University, 500 Glenridge Avenue, St Catharines, Ontario L2S 3A1, Canada
    Environ Toxicol Chem 28:921-30. 2009
    Concentrations of polychlorinated naphthalenes (PCNs) were determined in archived lake trout (Salvelinus namaycush) from Lake Ontario, North America, collected between 1979 and 2004 to evaluate their temporal trends and the factors ..
  47. ncbi Naphthalene exposure: effects on gene expression and proliferation in human cord blood cells
    Cristina Diodovich
    Laboratory of Hematotoxicology, ECVAM, Institute for Health and Consumer Protection, J.R.C, 21020 Ispra, Italy
    J Biochem Mol Toxicol 17:286-94. 2003
    ..Furthermore, macroarray analysis showed that naphthalene modified cord blood gene expression, inducing IL-8 precursor and T-cell transcription factor and decreasing the level of RNA-binding protein FUS/TLS...
  48. ncbi Synthetic selective inhibitors of coagulation factor Xa strongly inhibit thrombin generation without affecting initial thrombin forming time necessary for platelet activation in hemostasis
    M Ieko
    Departments of Internal Medicine, Health Sciences University of Hokkaido, Ishikari Tobetsu, Hokkaido, Japan
    J Thromb Haemost 2:612-8. 2004
    ....
  49. ncbi Two distinct classes of muscarinic action on hippocampal inhibitory synapses: M2-mediated direct suppression and M1/M3-mediated indirect suppression through endocannabinoid signalling
    Yuko Fukudome
    Department of Cellular Neurophysiology, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8640, Japan
    Eur J Neurosci 19:2682-92. 2004
    ..Thus, the muscarinic system can influence hippocampal functions by controlling different subsets of inhibitory synapses through the two distinct mechanisms...
  50. ncbi 'Knock-down' of spinal CB1 receptors produces abnormal pain and elevates spinal dynorphin content in mice
    Ahmet Dogrul
    Department of Pharmacology, School of Medicine, , 06018, Etlik, Ankara, Turkey
    Pain 100:203-9. 2002
    ....
  51. ncbi Rationale and design of a randomized, double-blind, parallel-group study of terutroban 30 mg/day versus aspirin 100 mg/day in stroke patients: the prevention of cerebrovascular and cardiovascular events of ischemic origin with terutroban in patients with
    M G Bousser
    Hôpital Lariboisière AP HP, INSERM U 740, Paris, France
    Cerebrovasc Dis 27:509-18. 2009
    ....
  52. ncbi Upregulation of spinal cannabinoid-1-receptors following nerve injury enhances the effects of Win 55,212-2 on neuropathic pain behaviors in rats
    Grewo Lim
    Department of Anesthesia and Critical Care, MGH Pain Center, WACC 324, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA 02114, USA
    Pain 105:275-83. 2003
    ..These results indicate that upregulation of spinal CB1Rs following peripheral nerve injury may contribute to the therapeutic effects of exogenous cannabinoids on neuropathic pain...
  53. ncbi Cannabinoid exposure alters learning of zebra finch vocal patterns
    Ken Soderstrom
    Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
    Brain Res Dev Brain Res 142:215-7. 2003
    ..Adult exposure did not change song that had already been learned. Our results demonstrate the potential for cannabinoid exposure to produce distinct effects during post-natal CNS development...
  54. ncbi Zebra finch CB1 cannabinoid receptor: pharmacology and in vivo and in vitro effects of activation
    K Soderstrom
    Florida State University, Department of Psychology, Tallahassee, FL 32306 1270, USA
    J Pharmacol Exp Ther 297:189-97. 2001
    ..Overall, cannabinoid inhibition of adult song production and conserved pharmacology render the zebra finch a promising model to investigate cannabinoid effects on learning by juveniles...
  55. ncbi Global anticoagulant effects of a synthetic anti-factor Xa inhibitor (DX-9065a): implications for interventional use
    Mahmut Tobu
    Department of Pathology and Pharmacology, Loyola University, Maywood, Illinois, USA
    Clin Appl Thromb Hemost 9:1-17. 2003
    ..DX-9065a did not affect the ecarin clotting time and thrombin time at concentrations up to 12.5 microgram/mL. Because DX-9065a prolonged the dRVVT, this may impact diagnostic screening of patients with systemic lupus erythematosus...
  56. ncbi Activation of cannabinoid receptors in rat brain by WIN 55212-2 produces coupling to multiple G protein alpha-subunits with different potencies
    P L Prather
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Mol Pharmacol 57:1000-10. 2000
    ....
  57. ncbi DX-9065a inhibition of factor Xa and the prothrombinase complex: mechanism of inhibition and comparison with therapeutic heparins
    Alireza R Rezaie
    Edward A Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, St Louis, Missouri, USA
    Thromb Haemost 89:112-21. 2003
    ..Further studies revealed that Tyr(99), a residue in the extended S2-S4 binding pocket of fXa, plays a key role in determination of specificity of the DX-9065a interaction...
  58. ncbi The development of a MIP-optosensor for the detection of monoamine naphthalenes in drinking water
    Angel Valero-Navarro
    Department of Analytical Chemistry, University of Granada, c Fuentenueva s n, 18071 Granada, Spain
    Biosens Bioelectron 24:2305-11. 2009
    ..Finally, we applied it to the analysis of 1-NA and 2-NA in tap and mineral waters, obtaining a 98% average recovery rate...
  59. ncbi Chemometric-assisted MIP-optosensing system for the simultaneous determination of monoamine naphthalenes in drinking waters
    Angel Valero-Navarro
    Department of Analytical Chemistry, University of Granada, Granada, Spain
    Talanta 78:57-65. 2009
    ..Predictive ability, accuracy, figures of merit, as well as advantages and disadvantages of the different strategies were discussed...
  60. ncbi Current external and internal exposure to naphthalene of workers occupationally exposed to polycyclic aromatic hydrocarbons in different industries
    Ralf Preuss
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen-Nuremberg, Schillerstrasse 25/29, 91054 Erlangen, Germany
    Int Arch Occup Environ Health 78:355-62. 2005
    ....
  61. ncbi In situ naphthalene bioactivation and nasal airflow cause region-specific injury patterns in the nasal mucosa of rats exposed to naphthalene by inhalation
    Myong Gyong Lee
    Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Pharmacol Exp Ther 314:103-10. 2005
    ....
  62. ncbi Secondary hyperparathyroidism: review of the disease and its treatment
    Angel L M de Francisco
    Servicio de Nefrologia, Hospital Universitario Valdecilla, Santander, Spain
    Clin Ther 26:1976-93. 2004
    ..The poor control of mineral and parathyroid hormone (PTH) levels characteristic of SHPT is associated with serious clinical consequences...
  63. ncbi In vivo effects of ozone exposure on protein adduct formation by 1-nitronaphthalene in rat lung
    Asa M Wheelock
    Department of Molecular Biosciences and Anatomy, School of Veterinary Medicine, University of California, Davis, USA
    Am J Respir Cell Mol Biol 33:130-7. 2005
    ..These studies identified in vivo protein targets for reactive 1-NN metabolites that are potentially associated with the mechanism of 1-NN toxicity and the synergistic effects of ozone...
  64. ncbi Bile acids induce MUC2 overexpression in human colon carcinoma cells
    Shumei Song
    Department of Gastrointestinal Medicine and Nutrition, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030-4009, USA
    Cancer 103:1606-14. 2005
    ..CONCLUSIONS: Bile acids induced mucin expression in human colon carcinoma cells by increasing MUC2 transcription through a process involving MAP kinase-independent, PKC-dependent activation of AP-1...
  65. ncbi Combined genomic and proteomic approaches identify gene clusters involved in anaerobic 2-methylnaphthalene degradation in the sulfate-reducing enrichment culture N47
    Drazenka Selesi
    Institute of Groundwater Ecology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    J Bacteriol 192:295-306. 2010
    ..The present work provides the first insight into the genetic basis of anaerobic 2-methylnaphthalene metabolism and delivers implications for understanding contaminant degradation...
  66. ncbi Atherosclerosis regression and TP receptor inhibition: effect of S18886 on plaque size and composition--a magnetic resonance imaging study
    Juan F Viles-Gonzalez
    Cardiovascular Biology Research Laboratory, Cardiovascular Institute, PO Box 1030, Mount Sinai School of Medicine, New York, NY 10029, USA
    Eur Heart J 26:1557-61. 2005
    ..The possibility of combining antithrombotic and antiatherosclerotic activity by means of the administration of TP inhibitors deserves further investigation in a clinical setting...
  67. ncbi Cinacalcet HCl attenuates parathyroid hyperplasia in a rat model of secondary hyperparathyroidism
    Matthew Colloton
    Department of Metabolic Disorders, Amgen, Inc, Thousand Oaks, California 91320, USA
    Kidney Int 67:467-76. 2005
    ..These results support a role for the CaR in regulating parathyroid cell proliferation. Therefore, cinacalcet HCl may represent a novel therapy for improving the management of secondary HPT...
  68. ncbi Cyclooxygenases, thromboxane, and atherosclerosis: plaque destabilization by cyclooxygenase-2 inhibition combined with thromboxane receptor antagonism
    Karine M Egan
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Circulation 111:334-42. 2005
    ..TP ligands, including COX-1 (but not COX-2)-derived TxA2, promote initiation and early progression of atherogenesis in Apobec-1/LDLR DKOs but appear unimportant in the maintenance of established disease...
  69. ncbi Enzymatic reactions in anaerobic 2-methylnaphthalene degradation by the sulphate-reducing enrichment culture N 47
    Michael Safinowski
    , , Wilhelmstr. 56, , Germany
    FEMS Microbiol Lett 240:99-104. 2004
    ..The two novel reactions presented here demonstrate that the original methyl-group of 2-methylnaphthalene is oxidised to the carboxyl group of 2-naphthoic acid in the upper part of the anaerobic degradation pathway...
  70. ncbi Polychlorinated dibenzo-p-dioxins, dibenzofurans, biphenyls, naphthalenes and polybrominated diphenyl ethers in the edible fish caught from the Baltic Sea and lakes in Finland
    Pirjo Isosaari
    National Public Health Institute, Department of Environmental Health, P O Box 95, FI 70701 Kuopio, Finland
    Environ Pollut 141:213-25. 2006
    ..dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), polychlorinated biphenyls (PCBs), polychlorinated naphthalenes (PCNs) and polybrominated diphenyl ethers (PBDEs)...
  71. ncbi Characterization of a structurally intact in situ lung model and comparison of naphthalene protein adducts generated in this model vs lung microsomes
    Ching Yu Lin
    Department of Molecular Biosciences, School of Veterinary Medicine, Molecular Structure Facility, University of California, Davis, California 95616, USA
    Chem Res Toxicol 18:802-13. 2005
    ..The proteins adducted and identified from in situ incubations were not the same proteins identified from microsomal incubations...
  72. ncbi Depurinating naphthalene-DNA adducts in mouse skin related to cancer initiation
    Muhammad Saeed
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Free Radic Biol Med 47:1075-81. 2009
    ..This is the same mechanism as other weak carcinogens, such as the natural and synthetic estrogens, and benzene...
  73. ncbi Calindol, a positive allosteric modulator of the human Ca(2+) receptor, activates an extracellular ligand-binding domain-deleted rhodopsin-like seven-transmembrane structure in the absence of Ca(2+)
    Kausik Ray
    Laboratory of Cellular Biology, NIDCD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:37013-20. 2005
    ..These findings demonstrate distinct allosteric linkages between Ca(2+) site(s) in the ECD and 7TMD and the 7TMD site(s) for calcimimetics...
  74. ncbi Cannabinoid CB1 receptors of the dorsal hippocampus are important for induction of conditioned place preference (CPP) but do not change morphine CPP
    Mohammad Reza Zarrindast
    Department of Pharmacology and Iranian National Center for Addiction Studies, Medical Sciences, University of Tehran, Iran
    Brain Res 1163:130-7. 2007
    ..These results suggest that endocannabinoid system in the dorsal hippocampus is important for the CPP paradigm. However, agents did not alter morphine-induced CPP...
  75. ncbi The safety of oral antifungal treatments for superficial dermatophytosis and onychomycosis: a meta-analysis
    Chia Hsuin Chang
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Am J Med 120:791-8. 2007
    ..We estimated the absolute risks of treatment termination and incidence of adverse liver outcomes among all commonly used oral antifungal treatments for superficial dermatophytosis and onychomycosis...
  76. ncbi Human cytochrome P450 2A13 efficiently metabolizes chemicals in air pollutants: naphthalene, styrene, and toluene
    Tatsuki Fukami
    Drug Metabolism and Toxicology, Division of Pharmaceutical Sciences, Graduate School of Medical Science, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    Chem Res Toxicol 21:720-5. 2008
    ....
  77. ncbi Uptake of selected PAHs from contaminated soils by rice seedlings (Oryza sativa) and influence of rhizosphere on PAH distribution
    Yu Hong Su
    Chemistry Department, Xinjiang University, Urumqi 830046, China
    Environ Pollut 155:359-65. 2008
    ..24 and 14%, respectively, based on PYR concentrations in rhizosphere and non-rhizosphere soils, the biomass of rice roots, and the dry soil weight...
  78. ncbi Direct in vitro evidence of the suppressive effect of cinacalcet HCl on parathyroid hormone secretion in human parathyroid cells with pathologically reduced calcium-sensing receptor levels
    Takehisa Kawata
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan
    J Bone Miner Metab 24:300-6. 2006
    ..Data from this in vitro analysis support the clinical application of cinacalcet in PHPT and SHPT therapy...
  79. ncbi Anaerobic degradation of naphthalene and 2-methylnaphthalene by strains of marine sulfate-reducing bacteria
    Florin Musat
    Max Planck Institute for Marine Microbiology, Celsiusstrasse 1, 28359 Bremen, Germany
    Environ Microbiol 11:209-19. 2009
    ..The inability to utilize 1-naphthol or 2-naphthol also excludes these compounds as free intermediates. Results leave open the possibility of naphthalene carboxylation, another previously suggested activation mechanism...
  80. ncbi Naphthalene emissions from moth repellents or toilet deodorant blocks determined using head-space and small-chamber tests
    Wan Kuen Jo
    Department of Environmental Engineering, Kyungpook National University, Daegu 702 701, Korea
    J Environ Sci (China) 20:1012-7. 2008
    ..The emission factor for naphthalene was nearly 100 times higher for a ball MR than for a gel or a paper MR. For the ball MR, the lower ACH level resulted in higher emission rate...
  81. ncbi The CB1 cannabinoid receptor mediates glutamatergic synaptic suppression in the hippocampus
    K A Takahashi
    Department of Neuroscience, Albert Einstein College of Medicine of Yeshiva University, Kennedy Center Room 703, 1410 Pelham Parkway South, Bronx, NY 10461, USA
    Neuroscience 139:795-802. 2006
    ..Our results strongly suggest that cannabinoid-induced suppression of the Sch-CA1 synapse is mediated by CB1. Non-canonical cannabinoid receptors do not seem to play a major role in inhibiting transmitter release at this synapse...
  82. ncbi Acute effects of the cannabinoid receptor agonist WIN55212-2 on dopamine release in rat: an in vivo electrochemical study
    Wun Chin Wu
    Department of Electrical Engineering of National Penghu University, Penghu
    Chin J Physiol 51:152-9. 2008
    ..SR141716A (3 mg/kg, i.p.) blocked the effects on DA release by WIN55212-2 (5 mg/kg, i.p.). Vehicle alone did not change DA release. These results suggest that cannabinoids modulate DA release in the striatum...
  83. ncbi Redundant mechanisms for anaphase chromosome movements: crane-fly spermatocyte spindles normally use actin filaments but also can function without them
    Lacramioara Fabian
    Biology Department, York University, Toronto, Ontario, Canada
    Protoplasma 225:169-84. 2005
    ....
  84. ncbi The OPTIMA study: assessing a new cinacalcet (Sensipar/Mimpara) treatment algorithm for secondary hyperparathyroidism
    PierGiorgio Messa
    Nephrology Division, CROFF Policlinico di Milano, Via della Commenda, 20122 Milano, Italy
    Clin J Am Soc Nephrol 3:36-45. 2008
    ..The primary end point was the proportion of patients with mean intact PTH < or =300 pg/ml during a 7-wk efficacy assessment phase...
  85. ncbi Parathyroidectomy in the calcimimetic era
    Grahame J Elder
    Centre for Transplant and Renal Research, Westmead Millennium Institute, Department of Renal Medicine, Westmead Hospital, Westmead, NSW 2145, Australia
    Nephrology (Carlton) 10:511-5. 2005
    ..This highlights the need for prospective studies with 'hard' endpoints, to establish evidence-based roles for parathyroidectomy and calcimimetic therapy...
  86. ncbi Depolarization-induced suppression of excitation in murine autaptic hippocampal neurones
    Alex Straiker
    Department of Anaesthesiology, University of Washington, Seattle, WA 98195, USA
    J Physiol 569:501-17. 2005
    ..With long-term exposure (approximately 18 h), delta9-THC also desensitizes CB1 receptors. Lastly, a functional endocannabinoid transporter is necessary for the expression of DSE...
  87. ncbi The Prevention of cerebrovascular and cardiovascular Events of ischemic origin with teRutroban in patients with a history oF ischemic strOke or tRansient ischeMic attack (PERFORM) study: baseline characteristics of the population
    M G Bousser
    Department of Neurology, Hôpital Lariboisière AP HP, INSERM U 740, Paris, France
    Cerebrovasc Dis 27:608-13. 2009
    ..Here we describe the baseline characteristics of the population...
  88. ncbi Systemic activation of the calcium sensing receptor produces acute effects on vascular tone and circulatory function in uremic and normal rats: focus on central versus peripheral control of vascular tone and blood pressure by cinacalcet
    Ryan M Fryer
    Integrative Pharmacology, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6119, USA
    J Pharmacol Exp Ther 323:217-26. 2007
    ..Moreover, subsequent mechanistic studies suggest that increases in MAP produced by cinacalcet may be mediated by reduced tonic NO synthase-dependent NO production subsequent to reductions in blood iCa2+...
  89. ncbi Bromoenol lactone promotes cell death by a mechanism involving phosphatidate phosphohydrolase-1 rather than calcium-independent phospholipase A2
    Lucia Fuentes
    Institute of Molecular Biology and Genetics, University of Valladolid School of Medicine, E 47005 Valladolid, Spain
    J Biol Chem 278:44683-90. 2003
    ....
  90. ncbi Morphology of nasal lesions in F344/N rats following chronic inhalation exposure to naphthalene vapors
    Philip H Long
    Pathology Associates, A Division of Charles River Laboratories, West Chester, Ohio 45069, USA
    Toxicol Pathol 31:655-64. 2003
    ....
  91. ncbi Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis
    Geoffrey A Block
    Denver Nephrologists, Denver, USA
    N Engl J Med 350:1516-25. 2004
    ..We report the results of two identical randomized, double-blind, placebo-controlled trials evaluating the safety and effectiveness of the calcimimetic agent cinacalcet hydrochloride...
  92. ncbi Site-specific metabolism of naphthalene and 1-nitronaphthalene in dissected airways of rhesus macaques
    Bridget Boland
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616, USA
    J Pharmacol Exp Ther 310:546-54. 2004
    ....
  93. ncbi L-NAME (N omega-nitro-L-arginine methyl ester), a nitric-oxide synthase inhibitor, and WIN 55212-2 [4,5-dihydro-2-methyl-4(4-morpholinylmethyl)-1-(1-naphthalenyl-carbonyl)-6H-pyrrolo[3,2,1ij]quinolin-6-one], a cannabinoid agonist, interact to evoke synerg
    S M Rawls
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA 19140, USA
    J Pharmacol Exp Ther 308:780-6. 2004
    ..The present data are the first evidence that drug combinations of NOS blockers and cannabinoid agonists produce synergistic hypothermia. Thus, NO and cannabinoid systems may interact to induce superadditive hypothermia...
  94. ncbi Naphthalene and its biomarkers as measures of occupational exposure to polycyclic aromatic hydrocarbons
    Stephen M Rappaport
    Department of Environmental Sciences and Engineering, School of Public Health, CB 7431, University of North Carolina, Chapel Hill, NC 27599 7431, USA
    J Environ Monit 6:413-6. 2004
    ..Since naphthalene has also been shown to be a respiratory carcinogen in several animal studies, it is also argued that naphthalene exposures should be monitored per se in industries with high levels of PAH...
  95. ncbi Cannabinoid agonist-induced sensitisation to morphine place preference in mice
    Carmen Manzanedo
    , , Universidad Complutense de Madrid, 28223 Madrid, Spain
    Neuroreport 15:1373-7. 2004
    ..Our results suggest the existence of cross-talk between cannabinoids and opiates on the sensitisation to morphine and the implication of the endocannabinoid system in the process of sensitisation to opiates...
  96. ncbi Functional localization of cannabinoid receptors and endogenous cannabinoid production in distinct neuron populations of the hippocampus
    Alexander F Hoffman
    Cellular Neurobiology Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Eur J Neurosci 18:524-34. 2003
    ....
  97. ncbi Cannabinoid modulation of sensitivity to time
    Jonathon D Crystal
    Department of Psychology, University of Georgia, Athens, GA 30602 3013, USA
    Behav Brain Res 144:57-66. 2003
    ..Computational modeling with an information processing theory of timing suggests that the reduction in sensitivity to time can be attributed to a disorder of attention...
  98. ncbi Contrasting effects of WIN 55212-2 on motility of the rat bladder and uterus
    Natalia Dmitrieva
    Program in Neuroscience, Florida State University, Tallahassee, Florida 32306-1270, USA
    J Neurosci 22:7147-53. 2002
    ....
  99. ncbi Modulation of gastric emptying and gastrointestinal transit in rats through intestinal cannabinoid CB(1) receptors
    Marco Landi
    Research Center Sanofi Midy, Sanofi-Synthelabo, SPA, Via G.B. Piranesi 38, 20137 Milan, Italy
    Eur J Pharmacol 450:77-83. 2002
    ..p. These findings are consistent with a primary role of peripheral cannabinoid CB(1) receptor mechanisms in gastrointestinal transit delay by specific agonists...
  100. ncbi Inhibition of GABAergic neurotransmission in the ventral tegmental area by cannabinoids
    Bela Szabo
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albertstrasse 25, D 79104 Freiburg i Br, Germany
    Eur J Neurosci 15:2057-61. 2002
    ..Depression of the GABAergic inhibitory input of dopaminergic neurons would increase their firing rate in vivo. Accordingly, dopamine release in the projection region of VTA neurons, the nucleus accumbens, would also increase...
  101. ncbi Functional tolerance and blockade of long-term depression at synapses in the nucleus accumbens after chronic cannabinoid exposure
    Alexander F Hoffman
    Cellular Neurobiology Branch, Section on Cellular Neurophysiology, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, United States Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 23:4815-20. 2003
    ..These data demonstrate that long-term exposure to the active ingredient of marijuana blocks synaptic plasticity in the NAc and reduces the sensitivity of GABAergic and glutamatergic synapses to both cannabinoids and opioids...

Research Grants132 found, 100 shown here

  1. LUNG INJURY BY NAPHTHALENES
    Alan Buckpitt; Fiscal Year: 2009
    ..Human exposure to naphthalenes occurs from a variety of sources including cigarette smoke and polluted air...
  2. LUNG INJURY BY NAPHTHALENES
    Alan Buckpitt; Fiscal Year: 1993
    ..These studies will provide a better basis for assessing risk of human exposure to naphthalene/2-methylnaphthalene and will result in methods that are applicable for assessing hazards of other pneumotoxic chemicals...
  3. LUNG INJURY BY NAPHTHALENES
    Alan Buckpitt; Fiscal Year: 2004
    ..One class of these toxic chemicals, the naphthalenes, are potentially important both because they result in a well defined injury to bronchiolar epithelial cells ..
  4. Treatment of Cannabinoid Withdrawal in Rhesus Monkeys
    LANCE MCMAHON; Fiscal Year: 2007
    ..abstract_text> ..
  5. Drug discrimination and THC withdrawal in monkeys
    LANCE MCMAHON; Fiscal Year: 2005
    ..abstract_text> ..
  6. Nicotine dependence: neuropharmacology in monkeys
    Lance R McMahon; Fiscal Year: 2010
    ..This grant investigates the receptor pharmacology of currently approved medications for smoking cessation and could lead to better treatment, thereby decreasing the devastating health consequence of tobacco use. ..
  7. Treatment of Cannabinoid Withdrawal in Rhesus Monkeys
    Lance R McMahon; Fiscal Year: 2010
    ..This competing continuation addresses a need to understand mechanisms at cannabinoid receptors that mediate the dependence liability of marijuana and the potential therapeutic utility of the cannabinoids. ..
  8. Pharmacotherapy of Cannabinoid Withdrawal: Pre-Clinical Studies
    Lance R McMahon; Fiscal Year: 2010
    ..Collectively, these specific aims provide a framework for developing novel pharmacotherapies of marijuana withdrawal that could markedly decrease marijuana use and dependence. ..
  9. Cannabinoid Regulation of Basal Ganglia Glutamate and GABA
    SCOTT RAWLS; Fiscal Year: 2007
    ..Our outcomes will be a first step in determining whether blocking endocannabinoid inactivation offers any therapeutic advantage over direct activation of cannabinoid receptors with marijuana. ..
  10. Synthesis of Bioactive Alkaloids and Peptides
    David A Evans; Fiscal Year: 2010
    ..Consequently, organic synthesis is a critical discipline that continues to have a pivotal impact on the fields of both medicine and biology. This grant will focus on the synthesis of bioactive alkaloids and peptides. ..
  11. Exogenous/endogenous cannabinoids--A comparison
    TORBJORN JARBE; Fiscal Year: 2006
    ....
  12. Synthesis of Polyketides and Terpenes
    David Evans; Fiscal Year: 2007
    ..As a consequence, organic synthesis is a critical discipline that continues to have an important impact on the fields of both medicine and biology. ..
  13. DIURNAL AND PULSATILE PTH SECRETION IN RENAL FAILURE
    William Goodman; Fiscal Year: 2001
    ....
  14. ASYMMETRIC SYNTHESIS OF IONOPHORE & MACROLIDE ANTIBIOTIC
    David Evans; Fiscal Year: 1993
    ....
  15. ASYMMETRIC SYNTHESIS OF VANCOMYCIN ANTIBIOTICS
    David Evans; Fiscal Year: 1993
    ..During the course of this project we intend to confirm (correct) the absolute stereochemical assignment of the principal members of this family by total synthesis...
  16. Synthesis of Polyketides and Terpenes
    David A Evans; Fiscal Year: 2010
    ..As a consequence, organic synthesis is a critical discipline that continues to have an important impact on the fields of both medicine and biology. ..
  17. Endogenous/exogenous cannabinoids: A comparison
    TORBJORN U JARBE; Fiscal Year: 2010
    ....
  18. ASYMMETRIC SYNTHESIS OF IONOPHORE/MACROLIDE ANTIBIOTICS
    David Evans; Fiscal Year: 1999
    ..The goal of these studies will be to reveal some of the general rules for predicting the stereochemical outcome of complex aldol fragment coupling reactions. ..
  19. Ca2+-Sensing Receptor: Novel Roles in Calcium Homeostasis
    Edward M Brown; Fiscal Year: 2010
    ..These studies should clarify important mechanisms by which the body regulates calcium in bodily fluids under normal circumstances and how these processes can go awry in disease states. ..
  20. CALCIUM RECEPTOR SIGNAL RECOGNITION AND TRANSDUCTION
    Edward M Brown; Fiscal Year: 2006
    ..abstract_text> ..
  21. Molecular mechanisms of altered calcium sensing in human parathyroid disease
    JOHN A contact OLSON; Fiscal Year: 2010
    ..Finally, by learning more about why parathyroid tumors don't sense calcium properly, we will be able to identify promising new approaches for treating patient with HPT using medications rather than surgery. ..
  22. MECHANISM OF IL-12 INHIBITION BY CANDIDA ALBICANS
    Mahmoud Ghannoum; Fiscal Year: 2009
    ..Data obtained from these studies will lead to a better understanding of the complex immune response to CA infection and may identify novel prevention/treatment strategies for candidiasis. ..
  23. Identification of early phase C. albicans biofilm proteins
    Mahmoud A Ghannoum; Fiscal Year: 2010
    ..albicans biofilms and may suggest potential therapeutic and diagnostic targets for the prevention, treatment, and diagnosis of oral Candida infections. ..
  24. Developing Biomarker-Based Prognostics In Breast Cancer
    John Olson; Fiscal Year: 2007
    ..abstract_text> ..
  25. INHIBITION OF PTH SECRETION: CaR AND THE CYTOSKELETON
    Edward M Brown; Fiscal Year: 2007
    ..Phosphorylation of caveolin-1 under high Ca 2+ conditions may anchor the CaR-PTH unit to the plasma membrane, limiting PTH secretion. ..
  26. CA2+-RECEPTOR: IMMUNE MODULATION IN VIVO AND IN VITRO
    Edward M Brown; Fiscal Year: 2007
    ..2) To identify and characterize activating antibodies to the CaR in persons with hypoparathyroidism. (3) To develop an animal model of activating and/or inactivating antibodies by immunization with the CaR's extracellular domain. ..
  27. Are Cardioprotective Medications Effective in ESRD?
    Theresa I Shireman; Fiscal Year: 2010
    ..This project will evaluate the effectiveness of cardioprotective medications in reducing cardiac deaths and hospitalizations in ESRD patients. ..
  28. PHOSPHOLIPASE B--MECHANISMS AUGMENTING CANDIDA VIRULENCE
    Mahmoud Ghannoum; Fiscal Year: 2003
    ..albicans. Using specific proteinase inhibitors and mutants deleted for both PLB1 and SAPs, we will determine whether these enzymes act in concert to enhance the virulence of C. albicans. ..
  29. Ca2+-RECEPTOR--SIGNAL RECOGNITION AND TRANSDUCTION
    Edward M Brown; Fiscal Year: 2003
    ..abstract_text> ..
  30. CALCIUM RECEPTOR SIGNAL RECOGNITION AND TRANSDUCTION
    Edward M Brown; Fiscal Year: 2000
    ..These studies should provide new insights into how the CaR regulates parathyroid function in health and disease states and, perhaps, into how it controls the function of other cells. ..
  31. PHARMACOLOGY OF BOVINE PARATHYROID CA++ RECEPTORS
    Edward M Brown; Fiscal Year: 2002
    ....
  32. Biology and Drug Resistance of Candida Biofilms
    Mahmoud Ghannoum; Fiscal Year: 2005
    ..albicans biofilms. By studying biofilm model systems and applying this knowledge to the patient population, we will gain a wealth of data about the biology and drug resistance of C. albicans in biofilms. ..