naphthalenes

Summary

Summary: Two-ring crystalline hydrocarbons isolated from coal tar. They are used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, preservatives, and, formerly, as topical antiseptics.

Top Publications

  1. ncbi Myosin-II-dependent localization and dynamics of F-actin during cytokinesis
    Kausalya Murthy
    Department of Biology and Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, 01003, USA
    Curr Biol 15:724-31. 2005
  2. ncbi Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis
    Geoffrey A Block
    Denver Nephrologists, Denver, USA
    N Engl J Med 350:1516-25. 2004
  3. ncbi Combined therapy with cinacalcet and low doses of vitamin D sterols in patients with moderate to severe secondary hyperparathyroidism
    Geoffrey A Block
    Denver Nephrologists, Denver, CO 80230, USA
    Nephrol Dial Transplant 23:2311-8. 2008
  4. ncbi Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes
    Birgit Heltweg
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 66:4368-77. 2006
  5. pmc Paricalcitol versus cinacalcet plus low-dose vitamin D therapy for the treatment of secondary hyperparathyroidism in patients receiving haemodialysis: results of the IMPACT SHPT study
    Markus Ketteler
    Division of Nephrology, Klinikum Coburg, Coburg, Germany
    Nephrol Dial Transplant 27:3270-8. 2012
  6. ncbi The ADVANCE study: a randomized study to evaluate the effects of cinacalcet plus low-dose vitamin D on vascular calcification in patients on hemodialysis
    Paolo Raggi
    Division of Cardiology, Emory University, Atlanta, GA, USA
    Nephrol Dial Transplant 26:1327-39. 2011
  7. ncbi Inhibition of interneuron firing extends the spread of endocannabinoid signaling in the cerebellum
    Anatol C Kreitzer
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
    Neuron 34:787-96. 2002
  8. ncbi Cinacalcet hydrochloride treatment significantly improves all-cause and cardiovascular survival in a large cohort of hemodialysis patients
    Geoffrey A Block
    Denver Nephrology Research Division, Denver, Colorado 80230, USA
    Kidney Int 78:578-89. 2010
  9. pmc Effects of cinacalcet and concurrent low-dose vitamin D on FGF23 levels in ESRD
    James B Wetmore
    University of Kansas Medical Center, MS 3002, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Clin J Am Soc Nephrol 5:110-6. 2010
  10. ncbi Synergistic effects of p38 mitogen-activated protein kinase inhibition with a corticosteroid in alveolar macrophages from patients with chronic obstructive pulmonary disease
    J Armstrong
    Medicines Evaluation Unit, National Institute for Health Research Translational Research Facility, University Hospital of South Manchester Foundation Trust, University of Manchester, Manchester, United Kingdom
    J Pharmacol Exp Ther 338:732-40. 2011

Detail Information

Publications298 found, 100 shown here

  1. ncbi Myosin-II-dependent localization and dynamics of F-actin during cytokinesis
    Kausalya Murthy
    Department of Biology and Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, 01003, USA
    Curr Biol 15:724-31. 2005
    ..The mechanism(s) that contribute to the spatially and temporally regulated assembly and disassembly of the CR at the cell equator are poorly understood...
  2. ncbi Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis
    Geoffrey A Block
    Denver Nephrologists, Denver, USA
    N Engl J Med 350:1516-25. 2004
    ..We report the results of two identical randomized, double-blind, placebo-controlled trials evaluating the safety and effectiveness of the calcimimetic agent cinacalcet hydrochloride...
  3. ncbi Combined therapy with cinacalcet and low doses of vitamin D sterols in patients with moderate to severe secondary hyperparathyroidism
    Geoffrey A Block
    Denver Nephrologists, Denver, CO 80230, USA
    Nephrol Dial Transplant 23:2311-8. 2008
    ....
  4. ncbi Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes
    Birgit Heltweg
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 66:4368-77. 2006
    ..Cambinol was well tolerated in mice and inhibited growth of Burkitt lymphoma xenografts. Inhibitors of NAD-dependent deacetylases may constitute novel anticancer agents...
  5. pmc Paricalcitol versus cinacalcet plus low-dose vitamin D therapy for the treatment of secondary hyperparathyroidism in patients receiving haemodialysis: results of the IMPACT SHPT study
    Markus Ketteler
    Division of Nephrology, Klinikum Coburg, Coburg, Germany
    Nephrol Dial Transplant 27:3270-8. 2012
    ....
  6. ncbi The ADVANCE study: a randomized study to evaluate the effects of cinacalcet plus low-dose vitamin D on vascular calcification in patients on hemodialysis
    Paolo Raggi
    Division of Cardiology, Emory University, Atlanta, GA, USA
    Nephrol Dial Transplant 26:1327-39. 2011
    ....
  7. ncbi Inhibition of interneuron firing extends the spread of endocannabinoid signaling in the cerebellum
    Anatol C Kreitzer
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
    Neuron 34:787-96. 2002
    ..Because interneurons can project over several hundred micrometers, this inhibition of firing allows cells to regulate synaptic inputs at distances well beyond the limits of endocannabinoid diffusion...
  8. ncbi Cinacalcet hydrochloride treatment significantly improves all-cause and cardiovascular survival in a large cohort of hemodialysis patients
    Geoffrey A Block
    Denver Nephrology Research Division, Denver, Colorado 80230, USA
    Kidney Int 78:578-89. 2010
    ..v. vitamin D. Definitive proof, however, of a survival advantage awaits the performance of randomized clinical trials...
  9. pmc Effects of cinacalcet and concurrent low-dose vitamin D on FGF23 levels in ESRD
    James B Wetmore
    University of Kansas Medical Center, MS 3002, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Clin J Am Soc Nephrol 5:110-6. 2010
    ..The effects of various treatments for secondary hyperparathyroidism on FGF23 levels in ESRD have not been examined in a clinical trial...
  10. ncbi Synergistic effects of p38 mitogen-activated protein kinase inhibition with a corticosteroid in alveolar macrophages from patients with chronic obstructive pulmonary disease
    J Armstrong
    Medicines Evaluation Unit, National Institute for Health Research Translational Research Facility, University Hospital of South Manchester Foundation Trust, University of Manchester, Manchester, United Kingdom
    J Pharmacol Exp Ther 338:732-40. 2011
    ..Combining a p38 MAPK inhibitor with a corticosteroid synergistically enhances the anti-inflammatory effects on LPS-mediated cytokine production by alveolar macrophages from patients with COPD and controls...
  11. ncbi Cannabinoids prevent lipopolysaccharide-induced neurodegeneration in the rat substantia nigra in vivo through inhibition of microglial activation and NADPH oxidase
    Eun Sook Chung
    Department of Biochemistry and Molecular Biology, School of Medicine Kyung Hee University, Seoul 130 701, Korea
    Brain Res 1451:110-6. 2012
    ..The present data suggest that cannabinoids may be beneficial for the treatment of neurodegenerative diseases, such as PD, that are associated with microglial activation...
  12. ncbi Bidirectional regulation of mu-opioid and CB1-cannabinoid receptor in rats self-administering heroin or WIN 55,212-2
    Liana Fattore
    Institute of Neuroscience, National Research Council CNR, Section of Cagliari, Italy
    Eur J Neurosci 25:2191-200. 2007
    ....
  13. ncbi Effects of the calcimimetic cinacalcet HCl on cardiovascular disease, fracture, and health-related quality of life in secondary hyperparathyroidism
    John Cunningham
    University College London, The Middlesex Hospital, London, UK
    Kidney Int 68:1793-800. 2005
    ..Cinacalcet, a calcimimetic that modulates the calcium-sensing receptor, reduces parathyroid hormone (PTH) secretion and lowers serum calcium and phosphorus concentrations in patients with end-stage renal disease (ESRD) and secondary HPT...
  14. ncbi Cinacalcet treatment and serum FGF23 levels in haemodialysis patients with secondary hyperparathyroidism
    Masahiro Koizumi
    Division of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine, Isehara, Japan
    Nephrol Dial Transplant 27:784-90. 2012
    ..Cinacalcet hydrochloride is effective in treating SHPT, but little is known as to whether treatment with cinacalcet alters these levels and whether pretreatment FGF23 levels predict response to this therapy...
  15. ncbi Stable-isotope probing of the polycyclic aromatic hydrocarbon-degrading bacterial guild in a contaminated soil
    Maiysha D Jones
    Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, CB 7431 Chapel Hill, NC 27599 7431, USA
    Environ Microbiol 13:2623-32. 2011
    ....
  16. ncbi Posttraining activation of CB1 cannabinoid receptors in the CA1 region of the dorsal hippocampus impairs object recognition long-term memory
    Julia R Clarke
    Centro de Memoria, Instituto de Pesquisas Biomédicas, Pontificia Universidade Catolica do Rio Grande do Sul, Av Ipiranga 6690, RS 90610 000 Porto Alegre, Brazil
    Neurobiol Learn Mem 90:374-81. 2008
    ..Our data indicate that activation of hippocampal CB1 receptors early after training hampers consolidation of object recognition memory...
  17. ncbi Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesis
    Yannick Marchalant
    Department of Psychology, The Ohio State University, Columbus, 43210, USA
    Neurobiol Dis 34:300-7. 2009
    ..Our results provide insight into the role of the endocannabinoid and vanilloid systems upon two different and detrimental aspects of normal and pathological aging, chronic neuroinflammation and decline in neurogenesis...
  18. pmc Opposing actions of chronic Delta9-tetrahydrocannabinol and cannabinoid antagonists on hippocampal long-term potentiation
    Alexander F Hoffman
    United States Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, Cellular Neurobiology Branch, Electrophysiology Research Unit, Baltimore, Maryland 21224, USA
    Learn Mem 14:63-74. 2007
    ..These data define consequences of repeated Delta(9)-THC exposure for synaptic plasticity in the hippocampus that may help explain memory impairments in humans following chronic marijuana use...
  19. ncbi Structure-activity relationships of the p38alpha MAP kinase inhibitor 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naph- thalen-1-yl]urea (BIRB 796)
    John Regan
    Department of Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals, Research and Development Center, 900 Ridgebury Road, Ridgefield, Connecticut 06877, USA
    J Med Chem 46:4676-86. 2003
    ..Finally, we describe several compounds that potently inhibit TNF-alpha production when dosed orally in mice...
  20. ncbi Towards selective antagonists of T-type calcium channels: design, characterization and potential applications of NNC 55-0396
    Ming Li
    Department of Pharmacology SL 83, Tulane University Health Science Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Cardiovasc Drug Rev 23:173-96. 2005
    ..We conclude that NNC 55-0396, by virtue of its modified structure, does not produce the metabolite that causes inhibition of L-type Ca2+ channel channels, thus rendering it more selective to T-type Ca2+ channels...
  21. ncbi Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities
    Christopher M Jenkins
    Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 279:48968-75. 2004
    ....
  22. ncbi Inhibition of nitric oxide production in RAW264.7 macrophages by cannabinoids and palmitoylethanolamide
    R A Ross
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, AB25 2ZD, Scotland, Aberdeen, UK
    Eur J Pharmacol 401:121-30. 2000
    ..In contrast, the inhibition by palmitoylethanolamide does not appear to be mediated by cannabinoid receptors...
  23. pmc nag genes of Ralstonia (formerly Pseudomonas) sp. strain U2 encoding enzymes for gentisate catabolism
    N Y Zhou
    School of Biological Sciences, University of Wales, Bangor, Gwynedd LL57 2UW, Wales, United Kingdom
    J Bacteriol 183:700-8. 2001
    ..NagJ is homologous to a glutathione S-transferase, and NagM and NagN are proteins homologous to each other and to other proteins of unknown function. Downstream of the operon is a partial sequence with homology to a transposase...
  24. ncbi CB1 cannabinoid receptors mediate anxiolytic effects: convergent genetic and pharmacological evidence with CB1-specific agents
    J Haller
    Institute of Experimental Medicine, Budapest, Hungary
    Behav Pharmacol 15:299-304. 2004
    ..This suggests that agonists of the former, or antagonists of the latter, are promising new compounds in the pharmacotherapy of anxiety...
  25. pmc Correlated species differences in the effects of cannabinoid ligands on anxiety and on GABAergic and glutamatergic synaptic transmission
    J Haller
    Institute of Experimental Medicine, Department of Behavioral Neurobiology, 1450 Budapest, PO Box 67, Hungary
    Eur J Neurosci 25:2445-56. 2007
    ..We suggest that the anxiety-related effects of cannabinoids depend on the relative cannabinoid responsiveness of GABAergic and glutamatergic neurotransmission...
  26. ncbi Polybrominated diphenyl ethers, polychlorinated naphthalenes and polycyclic musks in human fat from Italy: comparison to polychlorinated biphenyls and organochlorine pesticides
    Alessandra Schiavone
    Department of Environmental Science G Sarfatti, University of Siena, Via P A Mattioli 4, I 53100 Siena, Italy
    Environ Pollut 158:599-606. 2010
    Prior to this study, reports of occurrence of polycyclic musks and polychlorinated naphthalenes (PCNs) in human tissues from Italy were not available...
  27. ncbi Cinacalcet (KRN1493) effectively decreases the serum intact PTH level with favorable control of the serum phosphorus and calcium levels in Japanese dialysis patients
    Masafumi Fukagawa
    Division of Nephrology and Kidney Center, Kobe University School of Medicine, Chuo Ku, Kobe, Japan
    Nephrol Dial Transplant 23:328-35. 2008
    ..In this study, we examined the efficacy and safety of cinacalcet in Japanese patients on maintenance haemodialysis...
  28. ncbi Electronic polarizability as a predictor of biodegradation rates of dimethylnaphthalenes. an ab initio and density functional theory study
    Vito Librando
    Research Centre for Analysis, Monitoring and Minimization Methods of Environmental Risk, c o Department of Chemistry, University of Catania, viale A Doria 8, 95125 Catania, Italy
    Environ Sci Technol 41:1646-52. 2007
    ..The present approach is potentially suitable for applications on PAHs with higher molecular weight...
  29. pmc Reduced infarct size and accumulation of microglia in rats treated with WIN 55,212-2 after neonatal stroke
    D Fernández-López
    Department of Neurology, Neonatal Brain Disorders Center, University of California San Francisco, 521 Parnassus Avenue, Room C 215, San Francisco, CA 94143 0663, USA
    Neuroscience 207:307-15. 2012
    ..Cumulatively, our results show that the cannabinoid agonist WIN protects against neonatal focal stroke in part due to inhibitory effects on microglia...
  30. ncbi Neuroprotective effect of WIN 55,212-2 pretreatment against focal cerebral ischemia through activation of extracellular signal-regulated kinases in rats
    Bo Hu
    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an 710032, Shaanxi Province, China
    Eur J Pharmacol 645:102-7. 2010
    ..These findings suggest that the neuroprotective effect of WIN 55,212-2 pretreatment against focal cerebral ischemia is through the activation of extracellular signal-regulated kinases in rats...
  31. pmc Long-term treatment with cinacalcet and conventional therapy reduces parathyroid hyperplasia in severe secondary hyperparathyroidism
    Mario Meola
    Department of Internal Medicine, S Anna School of Advanced Studies, Nephrology and Dialysis Unit, University of Pisa, Italy
    Nephrol Dial Transplant 24:982-9. 2009
    ....
  32. ncbi Cannabinoid receptor agonist 13, a novel cannabinoid agonist: first in human pharmacokinetics and safety
    Anne Gardin
    Novartis Institutes for BioMedical Research, Basel, CH 4002, Switzerland
    Drug Metab Dispos 37:827-33. 2009
    ..Food intake increased CRA13 C(max) and AUC(0 - tz) by approximately 2-fold, whereas t(max) was unaffected...
  33. pmc Cinacalcet effectively reduces parathyroid hormone secretion and gland volume regardless of pretreatment gland size in patients with secondary hyperparathyroidism
    Hirotaka Komaba
    Division of Nephrology and Kidney Center, Kobe University School of Medicine, Kobe, Japan
    Clin J Am Soc Nephrol 5:2305-14. 2010
    ..However, it has not been proven whether parathyroid gland size predicts response to therapy and whether cinacalcet is capable of inducing a reduction in parathyroid volume...
  34. pmc Selective recognition of pyrimidine-pyrimidine DNA mismatches by distance-constrained macrocyclic bis-intercalators
    Matthias Bahr
    Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D 52056 Aachen, Germany
    Nucleic Acids Res 36:5000-12. 2008
    ..Altogether, our results demonstrate that macrocyclic distance-constrained bis-intercalators are efficient and selective mismatch-binding ligands that can interfere with mismatch-binding enzymes...
  35. ncbi Study design and subject baseline characteristics in the ADVANCE Study: effects of cinacalcet on vascular calcification in haemodialysis patients
    Jurgen Floege
    Division of Nephrology, RWTH University of Aachen, Aachen, Germany
    Nephrol Dial Transplant 25:1916-23. 2010
    ..We report the ADVANCE Study design and baseline subject characteristics...
  36. ncbi Neuronal cytoskeleton and synaptic densities are altered after a chronic treatment with the cannabinoid receptor agonist WIN 55,212-2
    Patricia Tagliaferro
    Instituto de Biologia Celular y Neurociencias Prof E De Robertis, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 3 er piso, C1121ABG, Buenos Aires, Argentina
    Brain Res 1085:163-76. 2006
    ....
  37. ncbi Cinacalcet reduces plasma intact parathyroid hormone, serum phosphate and calcium levels in patients with secondary hyperparathyroidism irrespective of its severity
    J M Frazao
    School of Medicine, Porto University, Porto, Portugal
    Clin Nephrol 76:233-43. 2011
    ..To evaluate the relationship between the severity of secondary hyperparathyroidism (SHPT) - defined in terms of baseline plasma intact parathyroid hormone (iPTH) level - and the magnitude of response to cinacalcet...
  38. pmc Functional mechanism of the abscisic acid agonist pyrabactin
    Qi Hao
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China
    J Biol Chem 285:28946-52. 2010
    ..The study provides a framework for the development of novel ABA agonists that may have applicable potentials in agriculture...
  39. pmc Thirsty plants and beyond: structural mechanisms of abscisic acid perception and signaling
    Karsten Melcher
    Laboratory of Structural Sciences, Van Andel Research Institute, 333 Bostwick Ave N E, Grand Rapids, MI 49503, USA
    Curr Opin Struct Biol 20:722-9. 2010
    ....
  40. pmc Group VIA phospholipase A2 (iPLA2beta) participates in angiotensin II-induced transcriptional up-regulation of regulator of g-protein signaling-2 in vascular smooth muscle cells
    Zhongwen Xie
    Department of Physiology and the Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
    J Biol Chem 282:25278-89. 2007
    ..Collectively, our results demonstrate that iPLA2beta participates in Ang II-induced transcriptional up-regulation of RGS2 in VSMC...
  41. ncbi The effect of chronic peripubertal cannabinoid treatment on deficient object recognition memory in rats after neonatal mPFC lesion
    Miriam Schneider
    Department of Psychiatry and Psychotherapy, University of Cologne, 50924 Cologne, Germany
    Eur Neuropsychopharmacol 17:180-6. 2007
    ..This study shows that behavioral deviations induced by neonatal mPFC lesions can be exacerbated by pubertal chronic cannabinoid treatment, leading to long-lasting impairments of mnemonic short-term information processing...
  42. pmc Apoptosis of insulin-secreting cells induced by endoplasmic reticulum stress is amplified by overexpression of group VIA calcium-independent phospholipase A2 (iPLA2 beta) and suppressed by inhibition of iPLA2 beta
    Sasanka Ramanadham
    Mass Spectrometry Resource, Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Washington University School of Medicine, Box 8127, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Biochemistry 43:918-30. 2004
    ..These findings indicate that iPLA(2)beta participates in ER stress-induced apoptosis, a pathway that promotes beta-cell death in diabetes...
  43. ncbi Macrocyclic DNA-mismatch-binding ligands: structural determinants of selectivity
    Anton Granzhan
    UMR176 CNRS, Institut Curie, Centre de Recherche, Centre Universitaire, 91405 Orsay, France
    Chemistry 16:878-89. 2010
    ..The study demonstrates that the topology of the ligands plays a crucial role in determining the mismatch-binding affinity and selectivity of the macrocyclic bisintercalators...
  44. ncbi Post-training CB1 cannabinoid receptor agonist activation disrupts long-term consolidation of spatial memories in the hippocampus
    T T Yim
    Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, Canada T1K 3M4
    Neuroscience 151:929-36. 2008
    ..Plausible pharmacological interactions between cannabinoids and other neurotransmitter systems and associated plasticity mechanisms are discussed...
  45. ncbi Group VIA calcium-independent phospholipase A2 mediates endothelial cell S phase progression
    Shane P Herbert
    Faculty of Biological Sciences, Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biol Chem 281:35709-16. 2006
    ..Consequently, iPLA2-VIA is a novel regulator of endothelial cell S phase progression, cell cycle residence, and angiogenesis...
  46. ncbi The CB1 receptor agonist, WIN 55,212-2, dose-dependently disrupts object recognition memory in adult rats
    Jean Ha Baek
    Dept of Pharmacology and Toxicology, School of Medical Sciences, University of Otago Medical School, Dunedin, New Zealand
    Neurosci Lett 464:71-3. 2009
    ..These results suggest that WIN can interfere with object recognition memory even in adult rats following a single injection of a low dose...
  47. ncbi Structure-activity study in the class of 6-(3'-hydroxyphenyl)naphthalenes leading to an optimization of a pharmacophore model for 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitors
    Sandrine Marchais-Oberwinkler
    8 2 Pharmaceutical and Medicinal Chemistry, Saarland University, P O Box 15 11 50, D 66041 Saarbrucken, Germany
    Mol Cell Endocrinol 301:205-11. 2009
    ..Compound 18 also showed a good selectivity toward 17beta-HSD2 and the estrogen receptors alpha and beta...
  48. ncbi Detection of JWH-018 metabolites in smoking mixture post-administration urine
    Tim Sobolevsky
    Moscow Antidoping Centre, Elizavetinsky per 10, 105005 Moscow, Russia
    Forensic Sci Int 200:141-7. 2010
    ..The parent compound was not detected in urine...
  49. ncbi In vitro phase I metabolism of the synthetic cannabimimetic JWH-018
    Annette Wintermeyer
    Institute of Legal Medicine, Medical Faculty, University of Cologne, Melatengürtel 60 62, 50823 Cologne, Germany
    Anal Bioanal Chem 398:2141-53. 2010
    ..N-dealkylation also in combination with both monohydroxylation and dihydrodiol formation of the N-dealkylated metabolite was detected. Finally, a metabolite was found carboxylated at the alkyl side chain...
  50. pmc A bromoenol lactone suicide substrate inactivates group VIA phospholipase A2 by generating a diffusible bromomethyl keto acid that alkylates cysteine thiols
    Haowei Song
    Medicine Department Mass Spectrometry Facility, Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biochemistry 45:1061-73. 2006
    ....
  51. pmc Depolarization-induced suppression of excitation in murine autaptic hippocampal neurones
    Alex Straiker
    Department of Anaesthesiology, University of Washington, Seattle, WA 98195, USA
    J Physiol 569:501-17. 2005
    ..With long-term exposure (approximately 18 h), delta9-THC also desensitizes CB1 receptors. Lastly, a functional endocannabinoid transporter is necessary for the expression of DSE...
  52. pmc Detection of genes involved in biodegradation and biotransformation in microbial communities by using 50-mer oligonucleotide microarrays
    Sung Keun Rhee
    Environmental Sciences Division, Oak Ridge National Laboratory, P O Box 2008, Oak Ridge, TN 37831 6038, USA
    Appl Environ Microbiol 70:4303-17. 2004
    ....
  53. ncbi Achieving NKF-K/DOQI bone metabolism and disease treatment goals with cinacalcet HCl
    Sharon M Moe
    Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Kidney Int 67:760-71. 2005
    ....
  54. ncbi Cannabinoids and morphine differentially affect HIV-1 expression in CD4(+) lymphocyte and microglial cell cultures
    P K Peterson
    Minneapolis Medical Research Foundation, 914 S Eighth Street, Minneapolis, MN 55404, USA
    J Neuroimmunol 147:123-6. 2004
    ..These in vitro findings support the notion that pharmacologic factors need to be considered in epidemiological studies and animal models that pertain to HIV-1 infection...
  55. pmc Immunoregulation of a viral model of multiple sclerosis using the synthetic cannabinoid R+WIN55,212
    J Ludovic Croxford
    Department of Microbiology Immunology, Interdepartmental Immunobiology Center, Northwestern University Medical School, 303 E Chicago Avenue, Chicago, IL 60611, USA
    J Clin Invest 111:1231-40. 2003
    ..Clinical trials investigating the therapeutic potential of cannabinoids for the symptomatic treatment of MS are ongoing, and this study demonstrates that they may also have potent immunoregulatory properties...
  56. ncbi Outcomes of secondary hyperparathyroidism in chronic kidney disease and the direct costs of treatment
    Melanie S Joy
    School of Medicine, Division of Nephrology and Hypertension, UNC Kidney Center, Univerisity of North Carolina, Chapel Hill, NC 27599 7155, USA
    J Manag Care Pharm 13:397-411. 2007
    ..The number of patients who will be identified and prescribed therapies for complications such as secondary hyperparathyroidism (SHPT) is greater than initially proposed...
  57. ncbi Identity between the Ca2+-independent phospholipase A2 enzymes from P388D1 macrophages and Chinese hamster ovary cells
    M A Balboa
    Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, California 92093 0601, USA
    J Biol Chem 272:8576-80. 1997
    ..Additionally, covalent modification of the CHO enzyme by [3H]bromoenol lactone is dependent on active enzyme as is the P388D1 iPLA2. Finally, both enzymes have the same specific activities under identical experimental conditions...
  58. ncbi Cyclic stretch-induced stress fiber dynamics - dependence on strain rate, Rho-kinase and MLCK
    Chin Fu Lee
    Department of Biomedical Engineering, Texas A and M University, College Station, TX 77843 3120, United States
    Biochem Biophys Res Commun 401:344-9. 2010
    ..These results shed new light on the mechanism by which stress fibers reorient in response to cyclic stretch in different regions of the actin cytoskeleton...
  59. pmc Bacterial metabolism of naphthalene: construction and use of recombinant bacteria to study ring cleavage of 1,2-dihydroxynaphthalene and subsequent reactions
    R W Eaton
    Environmental Research Laboratory, U S Environmental Protection Agency, Gulf Breeze, Florida 32561
    J Bacteriol 174:7542-54. 1992
    ..On the basis of the identification of the enzymes encoded by various clones, the gene order for the nah operon was shown to be p, A, B, F, C, E, D...
  60. ncbi The Calcimimetic agent AMG 073 lowers plasma parathyroid hormone levels in hemodialysis patients with secondary hyperparathyroidism
    William G Goodman
    Department of Medicine, Division of Nephrology, Medical Center, UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    J Am Soc Nephrol 13:1017-24. 2002
    ....
  61. ncbi Anaerobic degradation of naphthalene by a pure culture of a novel type of marine sulphate-reducing bacterium
    A Galushko
    Fakultat fur Biologie, Universitat Konstanz, Germany
    Environ Microbiol 1:415-20. 1999
    ..Quantification of substrate consumption, sulphide formation and formed cell mass revealed that naphthalene was completely oxidized with sulphate as the electron acceptor...
  62. ncbi A randomized, double-blind, placebo-controlled study to assess the efficacy and safety of cinacalcet HCl in participants with CKD not receiving dialysis
    Michel Chonchol
    University of Colorado Health Science Center, Division of Renal Diseases and Hypertension, Denver, CO 80262, USA
    Am J Kidney Dis 53:197-207. 2009
    ..Secondary hyperparathyroidism is observed in patients with early chronic kidney disease (CKD). This study investigated the safety and efficacy of cinacalcet for secondary hyperparathyroidism in participants with CKD not receiving dialysis...
  63. ncbi Cooperative endocannabinoid production by neuronal depolarization and group I metabotropic glutamate receptor activation
    Takako Ohno-Shosaku
    Department of Cellular Neurophysiology, Graduate School of Medical Science, Kanazawa University, Kanazawa 920 8640, Japan
    Eur J Neurosci 15:953-61. 2002
    ..Enhancement of DSI by DHPG was also observed in hippocampal slices. These results suggest that two pathways work in a cooperative manner to release endocannabinoids via a common intracellular cascade...
  64. pmc Physiologically based pharmacokinetic model for terbinafine in rats and humans
    Mahboubeh Hosseini-Yeganeh
    Faculty of Pharmacy, University of Sydney, Sydney, New South Wales 2006, Australia
    Antimicrob Agents Chemother 46:2219-28. 2002
    ....
  65. ncbi Tissue distribution of terbinafine in rats
    M Hosseini-Yeganeh
    Faculty of Pharmacy, College of Health Sciences, University of Sydney, Sydney, NSW, 2006, Australia
    J Pharm Sci 90:1817-28. 2001
    ..Uptake of terbinafine into brain (K(p) = 1.3) and muscle (K(p) = 1.0) was significantly lower. In conclusion, terbinafine displays extensive uptake to peripheral tissues, which contributes to the long elimination half-life of this drug...
  66. ncbi Complete sequence and genetic organization of pDTG1, the 83 kilobase naphthalene degradation plasmid from Pseudomonas putida strain NCIB 9816-4
    Jonathan J Dennis
    Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada, T6G 2E9
    J Mol Biol 341:753-68. 2004
    ....
  67. ncbi Cannabinoids attenuate capsaicin-evoked hyperalgesia through spinal and peripheral mechanisms
    L M Johanek
    Department of Psychiatry, University of Minnesota, 420 Delaware Street SE, Mayo Mail Code 392, Minneapolis, MN 55455, USA
    Pain 93:303-15. 2001
    ..These data show that cannabinoids possess antihyperalgesic properties at doses that alone do not produce antinociception, and are capable of acting at both spinal and peripheral sites...
  68. ncbi Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site
    Christopher Pargellis
    Department of Biology, Boehringer Ingelheim Pharmaceuticals, Research and Development Center, 900 Ridgebury Road, Ridgefield, Connecticut 06877, USA
    Nat Struct Biol 9:268-72. 2002
    ..One of the most potent compounds in this series, BIRB 796, has picomolar affinity for the kinase and low nanomolar inhibitory activity in cell culture...
  69. ncbi Two distinct classes of muscarinic action on hippocampal inhibitory synapses: M2-mediated direct suppression and M1/M3-mediated indirect suppression through endocannabinoid signalling
    Yuko Fukudome
    Department of Cellular Neurophysiology, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8640, Japan
    Eur J Neurosci 19:2682-92. 2004
    ..Thus, the muscarinic system can influence hippocampal functions by controlling different subsets of inhibitory synapses through the two distinct mechanisms...
  70. ncbi Cannabinoid receptor-mediated inhibition of the rat tail-flick reflex after microinjection into the rostral ventromedial medulla
    W J Martin
    Department of Psychology, Brown University, Providence, RI 02912, USA
    Neurosci Lett 242:33-6. 1998
    ..These results demonstrate that the cannabinoid receptor system participates in the descending control of nociception and raise the possibility that actions of endogenous cannabinoids in the RVM may modulate nociceptive responsiveness...
  71. ncbi Pharmacokinetics, pharmacodynamics, and safety of cinacalcet hydrochloride in hemodialysis patients at doses up to 200 mg once daily
    Robert Z Harris
    Department of Pharmacokinetics and Drug Metabolism, Amgen Inc, Thousand Oaks, CA 91360, USA
    Am J Kidney Dis 44:1070-6. 2004
    ..This study investigated the pharmacokinetics, pharmacodynamics, safety, and tolerability of cinacalcet HCl over a dose range of 25 to 300 mg/d in patients receiving dialysis...
  72. pmc Myosin light chain kinase is involved in lipopolysaccharide-induced disruption of colonic epithelial barrier and bacterial translocation in rats
    Raphael Moriez
    Institut National de la Recherche Agronomique, Neuro Gastroenterology and Nutrition Unit, 180 chemin de Tournefeuille, BP 3, 31931 Toulouse Cedex 9, France
    Am J Pathol 167:1071-9. 2005
    ..Inhibition of MLCK-dependent colonocyte cytoskeleton contraction by ML-7 prevents the LPS-induced alterations of CPP and its subsequent effects...
  73. pmc Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson's disease: role of CB(1) and TRPV1 receptors
    Maria Grazia Morgese
    Department of Biomedical Sciences, University of Foggia, Viale Luigi Pinto 1, 71100 Foggia, Italy
    Exp Neurol 208:110-9. 2007
    ..Our data indicate that pharmacological blockade of TRPV1 receptors unmasks the anti-dyskinetic effects of FAAH inhibitors and that CB(1) and TRPV1 receptors play opposite roles in levodopa-induced dyskinesias...
  74. ncbi Role of an endoplasmic reticulum Ca(2+)-independent phospholipase A(2) in oxidant-induced renal cell death
    Brian S Cummings
    Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Physiol Renal Physiol 283:F492-8. 2002
    ..These results are the first to demonstrate the expression and subcellular localization of an ER-iPLA(2). These results also suggest that ER-iPLA(2) functions to protect against oxidant-induced lipid peroxidation and oncosis...
  75. ncbi Ca2+-independent phospholipase A2 enhances store-operated Ca2+ entry in dystrophic skeletal muscle fibers
    François Xavier Boittin
    Laboratory of Pharmacology, Geneva Lausanne School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, 1211 Geneva 4, Switzerland
    J Cell Sci 119:3733-42. 2006
    ..The Ca2+-independent phospholipase A2 pathway therefore appears as an attractive target to reduce excessive Ca2+ influx and subsequent degeneration occurring in dystrophic fibers...
  76. ncbi Studies on the different modes of action of the anticoagulant protease inhibitors DX-9065a and Argatroban. I. Effects on thrombin generation
    Hajime Nagashima
    New Product Research Laboratories II, Daiichi Pharmaceutical Co, Ltd, Tokyo 104 8369, Japan
    J Biol Chem 277:50439-44. 2002
    ..This study demonstrates differential inhibition of thrombin generation by fXa and thrombin inhibitors and has implications for the pharmacological regulation of blood coagulation by the anticoagulant protease inhibitors...
  77. pmc Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non-small cell lung cancer growth and metastasis
    Anju Preet
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Cancer Prev Res (Phila) 4:65-75. 2011
    ..These results suggest that CB1 and CB2 could be used as novel therapeutic targets against NSCLC...
  78. pmc D2 dopamine receptor activation facilitates endocannabinoid-mediated long-term synaptic depression of GABAergic synaptic transmission in midbrain dopamine neurons via cAMP-protein kinase A signaling
    Bin Pan
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Neurosci 28:14018-30. 2008
    ....
  79. ncbi Red yeast rice increases excretion of bile acids in hamsters
    Ka Ying Ma
    Food and Nutritional Sciences Program, Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Biomed Environ Sci 22:269-77. 2009
    ..To investigate the hypocholesterolemic activity of red yeast rice (RYR) and its underlying mechanism...
  80. ncbi Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: an integrated analysis of two double-blind, randomised controlled trials
    Jon L Pryor
    University of Minnesota, Minneapolis, MN 55455, USA
    Lancet 368:929-37. 2006
    ..No drugs are approved for treatment of premature ejaculation. Our aim was to determine the efficacy and tolerability of on-demand dapoxetine in patients with severe premature ejaculation...
  81. pmc Cinacalcet HCl and concurrent low-dose vitamin D improves treatment of secondary hyperparathyroidism in dialysis patients compared with vitamin D alone: the ACHIEVE study results
    Steven Fishbane
    Winthrop University Hospital, Department of Nephrology, Mineola, New York 11501, USA
    Clin J Am Soc Nephrol 3:1718-25. 2008
    ..The ACHIEVE study was designed to test two treatment strategies for achieving KDOQI goals...
  82. ncbi Chronic exposure to cannabinoids during adolescence but not during adulthood impairs emotional behaviour and monoaminergic neurotransmission
    Francis Rodriguez Bambico
    Neurobiological Psychiatry Unit, Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, Canada H3A1A1
    Neurobiol Dis 37:641-55. 2010
    ..These suggest that long-term exposure to cannabinoids during adolescence induces anxiety-like and depression-like behaviours in adulthood and that this may be instigated by serotonergic hypoactivity and noradrenergic hyperactivity...
  83. ncbi Cyclooxygenases, thromboxane, and atherosclerosis: plaque destabilization by cyclooxygenase-2 inhibition combined with thromboxane receptor antagonism
    Karine M Egan
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Circulation 111:334-42. 2005
    ..We addressed this issue and the role of TxA2 in the promotion and regression of diffuse, established atherosclerosis in Apobec-1/LDLR double KOs (DKOs)...
  84. ncbi Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia
    Judith Branger
    Department of Infectious Diseases, Tropical Medicine, and AIDS, Academic Medical Center, and CLB and Laboratory for Clinical and Experimental Immunology, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 168:4070-7. 2002
    ..Furthermore, the anti-inflammatory potential of an oral p38 MAPK inhibitor in humans in vivo suggests that p38 MAPK inhibitors may provide a new therapeutic option in the treatment of inflammatory diseases...
  85. ncbi Pharmacodynamics of the type II calcimimetic compound cinacalcet HCl
    Edward F Nemeth
    Amgen, Inc, Thousand Oaks, CA 91320 1799, USA
    J Pharmacol Exp Ther 308:627-35. 2004
    ..The present findings provide compelling evidence that cinacalcet HCl is a potent and stereoselective activator of the parathyroid CaR and, as such, might be beneficial in the treatment of hyperparathyroidism...
  86. ncbi Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammalian iPL
    Christopher M Jenkins
    Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 277:32807-14. 2002
    ....
  87. ncbi Suppression by WIN55212-2, a cannabinoid receptor agonist, of inflammatory reactions in mouse ear: Interference with the actions of an endogenous ligand, 2-arachidonoylglycerol
    Saori Oka
    Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Tsukui gun, Kanagawa 199 0195, Japan
    Eur J Pharmacol 538:154-62. 2006
    ..These results suggest that the anti-inflammatory activity of WIN55212-2 is attributable, at least in part, to interference with the actions of the endogenous ligand, 2-arachidonoylglycerol...
  88. ncbi Calcium-independent phospholipase A2 modulates cytosolic oxidant activity and contractile function in murine skeletal muscle cells
    Ming C Gong
    Dept of Physiology, Univ of Kentucky Medical Center, 800 Rose St, Lexington, KY 40536, USA
    J Appl Physiol 100:399-405. 2006
    ..These findings suggest that constitutively expressed iPLA2 modulates oxidant activity in skeletal muscle fibers by supporting ROS production, thereby influencing contractile properties and fatigue characteristics...
  89. pmc Combined genomic and proteomic approaches identify gene clusters involved in anaerobic 2-methylnaphthalene degradation in the sulfate-reducing enrichment culture N47
    Drazenka Selesi
    Institute of Groundwater Ecology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    J Bacteriol 192:295-306. 2010
    ..The present work provides the first insight into the genetic basis of anaerobic 2-methylnaphthalene metabolism and delivers implications for understanding contaminant degradation...
  90. ncbi Behavioural disturbances and altered Fos protein expression in adult rats after chronic pubertal cannabinoid treatment
    Nico Wegener
    Brain Research Institute, Department of Neuropharmacology, University of Bremen, Bremen, Germany
    Brain Res 1253:81-91. 2009
    ....
  91. ncbi Polychlorinated naphthalenes (PCNs) in riverine and marine sediments of the Laizhou Bay area, North China
    Xiaohui Pan
    Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China
    Environ Pollut 159:3515-21. 2011
    ..In marine sediments, it was suggested that PCNs along the coast of Laizhou Bay were mainly controlled by riverine input. While in the central bay, PCN distributions were possibly impacted by combined multiple factors...
  92. ncbi Early initiation of cinacalcet for the treatment of secondary hyperparathyroidism in hemodialysis patients: a three-year clinical experience
    Leonardo Lucchi
    Nephrology and Dialysis, Internal Medicine, Azienda Policlinico, Modena, Italy
    Artif Organs 35:1186-93. 2011
    ..These results suggest that the metabolic control obtained with low-dose CN administered early in the course of SHPT can be maintained or increased over time...
  93. ncbi The calcimimetic AMG 641 abrogates parathyroid hyperplasia, bone and vascular calcification abnormalities in uremic rats
    Charles Henley
    Department of Metabolic Disorders, Amgen Inc, Thousand Oaks, CA 91320, USA
    Eur J Pharmacol 616:306-13. 2009
    ..These results suggest that calcimimetics can reduce the development of vascular calcification, parathyroid hyperplasia and bone abnormalities associated with secondary hyperparathyroidism...
  94. ncbi Economic analysis of cinacalcet in combination with low-dose vitamin D versus flexible-dose vitamin D in treating secondary hyperparathyroidism in hemodialysis patients
    Theresa I Shireman
    Department of Preventive Medicine and Public Health and the Landon Center on Aging, University of Kansas Medical Center, Kansas City, KS, USA
    Am J Kidney Dis 56:1108-16. 2010
    ..The economic implications of these treatment regimens have not been explored...
  95. ncbi Meta-analysis of biochemical and patient-level effects of calcimimetic therapy
    Giovanni F M Strippoli
    NHMRC Centre for Clinical Research Excellence in Renal Medicine, Cochrane Renal Group, School of Public Health, University of Sydney, Australia
    Am J Kidney Dis 47:715-26. 2006
    ..We conducted a meta-analysis to evaluate outcomes of therapy with these novel agents...
  96. pmc Simultaneous control of PTH and CaxP Is sustained over three years of treatment with cinacalcet HCl
    Stuart M Sprague
    Evanston Northwestern Healthcare and Northwestern University Feinberg School of Medicine, Evanston, IL 60201, USA
    Clin J Am Soc Nephrol 4:1465-76. 2009
    ..Final efficacy analysis was at week 180...
  97. pmc Agonist-induced calcium entry correlates with STIM1 translocation
    Kehinde Ross
    Dermatological Sciences, Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom
    J Cell Physiol 211:569-76. 2007
    ..Thus by differentially regulating store-refilling after agonist-mediated depletion, LPA and UTP may exert distinct effects on the duration of STIM1 localization at the plasma membrane, and thus, on the magnitude and duration of ACE...
  98. ncbi Dose determination of cinacalcet hydrochloride in Japanese hemodialysis patients with secondary hyperparathyroidism
    Takashi Akiba
    Department of Blood Purification and Internal Medicine, Kidney Center, Tokyo Women s Medical University, Tokyo, Japan
    Ther Apher Dial 12:117-25. 2008
    ..On the basis of both efficacy and safety results, 25 mg has been identified as the optimal starting dose of cinacalcet for Japanese hemodialysis patients with secondary hyperparathyroidism...
  99. ncbi Polychlorinated naphthalenes and other dioxin-like compounds in Elbe River sediments
    Werner Brack
    UFZ Helmholtz Centre for Environmental Research, Leipzig, Germany
    Environ Toxicol Chem 27:519-28. 2008
    ..The investigation focused on polychlorinated naphthalenes (PCNs) that have not been determined previously in the Elbe River...
  100. pmc 1-Pentyl-3-phenylacetylindoles and JWH-018 share in vivo cannabinoid profiles in mice
    Jenny L Wiley
    RTI International, Research Triangle Park, NC 27709 2194, USA
    Drug Alcohol Depend 123:148-53. 2012
    ..Although abused by humans, most published research on this class of compounds has been performed in vitro. The purpose of this study was to evaluate a novel series of 1-pentyl-3-phenylacetylindoles in mice...
  101. ncbi Atmospheric pressure photoionization mass spectrometry. Ionization mechanism and the effect of solvent on the ionization of naphthalenes
    Tiina J Kauppila
    Viikki Drug Discovery Technology Center, Department of Pharmacy, University of Helsinki, Finland
    Anal Chem 74:5470-9. 2002
    ..atmospheric pressure photoionization and the effect of solvent on the ionization efficiency was studied using 7 naphthalenes and 13 different solvent systems...

Research Grants68

  1. Cannabinoid Regulation of Basal Ganglia Glutamate and GABA
    SCOTT RAWLS; Fiscal Year: 2007
    ..Our outcomes will be a first step in determining whether blocking endocannabinoid inactivation offers any therapeutic advantage over direct activation of cannabinoid receptors with marijuana. [unreadable] [unreadable] [unreadable]..
  2. LUNG INJURY BY NAPHTHALENES
    Alan Buckpitt; Fiscal Year: 2009
    ..Human exposure to naphthalenes occurs from a variety of sources including cigarette smoke and polluted air...
  3. METABOLISM & CARCINOGENICITY OF HALOAROMATIC POLLUTANTS
    Stephen Safe; Fiscal Year: 1980
    The metabolically-mediated toxicity of halogenated aromatic pollutants (polyhalogenated biphenyls, benzenes, naphthalenes and p-terphenyls) depends on a variety of factors which include the nature of the halogen atom, the nature of the ..
  4. Drug discrimination and THC withdrawal in monkeys
    LANCE MCMAHON; Fiscal Year: 2005
    ..abstract_text> ..
  5. Pharmacotherapy of Cannabinoid Withdrawal: Pre-Clinical Studies
    Lance R McMahon; Fiscal Year: 2010
    ..Collectively, these specific aims provide a framework for developing novel pharmacotherapies of marijuana withdrawal that could markedly decrease marijuana use and dependence. ..
  6. Can beta-lactam antibiotics decrease morphine physical dependence?
    SCOTT RAWLS; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  7. PRIMARY HYPERPARATHYROIDISM: NON-CLASSICAL MANIFESTATIONS
    Shonni Silverberg; Fiscal Year: 2009
    ..abstract_text> ..
  8. DIURNAL AND PULSATILE PTH SECRETION IN RENAL FAILURE
    William Goodman; Fiscal Year: 2001
    ....
  9. Tools for mapping transcriptional networks
    Uri Alon; Fiscal Year: 2006
    ..We expect that the analysis tools and concepts developed in E. coli will be very useful in mapping complex regulatory circuits in other cell types. [unreadable] [unreadable]..
  10. Nasal dosimetry of diacetyl and butyric acid vapors
    John Morris; Fiscal Year: 2005
    ....
  11. NON-OPIOID ANALGESICS DERIVED FROM IMPROGAN
    LINDSAY HOUGH; Fiscal Year: 2006
    ..These experiments will help to discover the mechanism of action of this novel class of agents, and lead to the development of new pharmacotherapies for pain. ..
  12. Azinomycins - Total Synthesis and Mechanism of Action
    Robert Coleman; Fiscal Year: 2007
    ..abstract_text> ..
  13. Asymmetric Synthesis of Cytotoxic Natural Products
    Robert Coleman; Fiscal Year: 2005
    ..abstract_text> ..
  14. TOWARD THE OPTIMAL TIMING OF INITIATION OF DIALYSIS
    Glenn Chertow; Fiscal Year: 2003
    ..The investigators have provided additional preliminary studies and have provided an extensive, detailed example of how the Monte Carlo models will be specified, validated, and optimized. ..
  15. Developmental Psychopharmacology of Antipsychotics
    JENNY WILEY; Fiscal Year: 2007
    ..This information will help to provide a more rational basis for making treatment decisions concerning children and adolescents who may benefit from treatment with an antipsychotic. [unreadable] [unreadable]..
  16. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 2009
    ..abstract_text> ..
  17. Leptin Action and Resistance in POMC-Neurons
    SHANE HENTGES; Fiscal Year: 2005
    ..abstract_text> ..
  18. Joint Action Analysis of Poly-drug Withdrawal
    Robert Raffa; Fiscal Year: 2006
    ..g., electrophysiologic or molecular biology techniques. An improved understanding of how withdrawal is influenced by poly-drug abuse could lead to development of enhanced clinical treatment. ..
  19. Mechanisms of Growth Factor-Estrogen Receptor Crosstalk
    Stephen Safe; Fiscal Year: 2006
    ..abstract_text> ..
  20. DESIGN AND SYNTHESIS OF NONPEPTIDE PROTEASE INHIBITORS
    Arun K Ghosh; Fiscal Year: 2010
    ..This research integrates organic synthesis, protein-ligand x-ray crystallography, molecular modeling and in-depth virus and cell-biological studies to design the next generation of HIV-1 protease inhibitors. ..
  21. MECHANISMS OF CELL INJURY IN BURN COMPLICATED BY SEPSIS
    Deborah Carlson; Fiscal Year: 2006
    ..The proposed work focuses on five specific aims to increase our understanding of the cellular events involved in burn and sepsis-related myocardial injury. ..
  22. Disorders of Syntactic Comprehension
    DAVID NORMAN CAPLAN; Fiscal Year: 2011
    ..The results could have important consequences for howwe think of these disorders and the neural organization that supports these functions. ..
  23. Regulation of vascular smooth muscle calcium sensitivity
    Paul H Ratz; Fiscal Year: 2010
    ..The Specific Aim of this study will be to test the hypothesis that ROK and PKCzeta both mediate KCI- induced Ca sensitization of FA, and that iPLA2 and PI3K are required as upstream activators of ROK and PKCzeta. ..
  24. Novel Inhibitors of Akt Signaling in Pancreatic Cancer
    Garth Powis; Fiscal Year: 2009
    ..The PtdIns-3-kinase/Akt signaling pathway is upregulated in many pancreatic cancers making it an ideal target for drugs to treat the disease. ..
  25. MECHANISMS OF CANNABINOID'S ANTIEMETIC ACTIONS
    NISSAR DARMANI; Fiscal Year: 2007
    ..The results will have important implications for the therapeutic utility of these "agonist antiemetics". [unreadable] [unreadable]..
  26. Synthesis of Polyketides and Terpenes
    David A Evans; Fiscal Year: 2010
    ..As a consequence, organic synthesis is a critical discipline that continues to have an important impact on the fields of both medicine and biology. ..
  27. NEW AMINO-PROTECTING GROUPS AND COUPLING REAGENTS
    LOUIS CARPINO; Fiscal Year: 2009
    ..Microwave irradiation is expected to allow for the most efficient syntheses, especially with Bsmoc and HOAt-based chemistry. ..
  28. TOXICOLOGY OF ENVIRONMENT CONTAMINANTS
    Stephen Safe; Fiscal Year: 2007
    ..The proposed training program will continue to provide trainees with a challenging academic and research environment that will prepare them for future careers in academic, industry and government. ..
  29. Gender differences in the interactions between endocannabinoids and stress
    Cecilia Hillard; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  30. Nanoscale-Natural Products Chemistry
    TADEUSZ MOLINSKI; Fiscal Year: 2009
    ....
  31. ANTIFUNGALS FROM MARINE INVERTEBRATES--AIDS ADJUVANTS
    Tadeusz F Molinski; Fiscal Year: 2010
    ..Optimized leads identified from those libraries will be advanced to in vitro and in vivo trials. ..
  32. Alcoholic Hepatitis: Molecular Mechanisms
    Stephen Safe; Fiscal Year: 2008
    ..The long-term goal of this project is to device appropriate therapies that will prevent neutrophilic steatohepatitis in chronic alcoholics by reducing neutrophil infiltration into liver. [unreadable] [unreadable] [unreadable]..
  33. Opioids: Relative Reinforcing Strength and Dependence
    Carol Paronis; Fiscal Year: 2008
    ..Results of these studies will improve our ability to assess the effectiveness with which agonist-based medications may combat its addictive power. ..
  34. Sex Differences in Endocannabioid-Mediated Behaviors
    Christian Reich; Fiscal Year: 2008
    ..Fear conditioning will be performed with established classical-conditioning protocols. [unreadable] [unreadable]..
  35. Monellin activates the human sweet taste receptor
    Emeline Maillet; Fiscal Year: 2008
    ..Knowledge of the structure/function relationship of TIRs may be valuable in the development of novel, low caloric sweeteners to help fight against diet-related disorders such as obesity and diabetes. ..
  36. CATCH: Mechanochemistry and Regulation in Smooth Muscle
    Thomas Butler; Fiscal Year: 2008
    ..4) Determination of the extent of involvement of myosin crossbridges in catch force maintenance by measurements of changes in orientation of fluorescent probes attached to the regulatory light chain. ..
  37. CA2+ RECEPTOR, PTHRP & MALIGNANCY-INDUCED OSTEOLYSIS
    Edward M Brown; Fiscal Year: 2004
    ..abstract_text> ..
  38. Function of a Novel Matrix Junction in Endothelial Cells
    Jonathan Jones; Fiscal Year: 2005
    ..In aim 3, we will analyze the function(s) of components of the VMA in angiogenesis in vivo. These studies will provide new insight into the role of integrin/matrix interactions in angiogenesis. ..
  39. PAIN MODULATION BY ENDOGENOUS CANNABINOIDS
    J Walker; Fiscal Year: 2004
    ..The experiments will determine the peripheral fiber types and the spinal cord neurons and neural pathways that induce the release of anandamide. ..
  40. NEUROLOGICAL BASIS OF PAIN: ROLE OF CANNABINOIDS
    J Walker; Fiscal Year: 2003
    ..The results of these studies will reveal mechanisms by which cannabinoids modulate the pathological pain, and suggests future studies directed at determining the role of endocannabinoids in pain processing. ..
  41. ESTROGEN INDUCED RESPONSES VIA ER/SPL COMPLEXES
    Stephen Safe; Fiscal Year: 2002
    ..These results will ultimately facilitate design of chemotherapeutic approaches which target specific genes. ..
  42. P450 MEDIATED LUNG TOXICITY
    Alan Buckpitt; Fiscal Year: 2002
    ....
  43. MARIJUANA WITHDRAWAL
    J Walker; Fiscal Year: 2002
    ..In addition, the investigations in the hippocampus may have relevance to learning and memory and thus have implications for certain mental illnesses such as Alzheimer's disease or other diseases that affect mental health. ..
  44. ASYMMETRIC SYNTHESIS OF VANCOMYCIN ANTIBIOTICS
    David Evans; Fiscal Year: 2001
    ..During the course of this project we intend to confirm (correct) the absolute stereochemical assignments of the principal members of this family by total synthesis. ..
  45. MECHANISMS OF CANNABINOIDS ANTIEMETIC ACTIONS
    NISSAR DARMANI; Fiscal Year: 2001
    ..The results will define an important role for the cannabinoid receptors in the vomiting circuits and may implicate an antiemetic role for the endogenous cannabinoids. ..
  46. ALKYL PCDFS--INHIBITION OF MAMMARY CANCER
    Stephen Safe; Fiscal Year: 2001
    ..Thus the proposed studies will define a new mechanism-based class of antiestrogens that can be used alone or in combination with tamoxifen for treatment of breast and endometrial cancer. ..
  47. DEVELOPMENT OF LIGAND ASSISTED ASYMMETRIC SYNTHESES
    Arun Ghosh; Fiscal Year: 2001
    ..Besides the broad range of scope and generality, this line of research will provide excellent opportunities to teach and train graduate and undergraduate students in the laboratory. ..
  48. ACQUISITION OF MIRCOARRAY SPOTTER, READER, SOFTWARE
    Alan Buckpitt; Fiscal Year: 2001
    ..abstract_text> ..
  49. MICROPET: HIGH RESOLUTION SMALL ANIMAL PET SCANNER
    Ned Kalin; Fiscal Year: 2001
    ..This scanner will also enhance research efforts in such wide-ranging areas as cardiology, oncology neurology, radiology and medical physics. ..
  50. Role of Central CRH in Stress-Induced Behavior
    Ned Kalin; Fiscal Year: 2006
    ....
  51. Chronic Cannabinoids, Tumor Growth and Hyperalgesia
    DARRYL HAMAMOTO; Fiscal Year: 2005
    ..Positive results from these studies would suggest that cannabinoids could be useful for the treatment of cancer pain. ..
  52. Dermal Exposure to 1,6-Hexamethylene Diisocyanate
    Leena Nylander French; Fiscal Year: 2005
    ..abstract_text> ..
  53. Brain Endocannabinoids and Chronic Stress
    Cecilia Hillard; Fiscal Year: 2005
    ..The successful completion of these studies will enhance our understanding of the processes involved in the adaptation of the brain to chronic stress. ..
  54. ASYMMETRIC SYNTHESIS OF IONOPHORE/MACROLIDE ANTIBIOTICS
    David Evans; Fiscal Year: 2005
    ..Our goal has been to set in place all of the reactions necessary for the rapid assemblage of any polyketide target structure. ..
  55. Coactivation of Estrogen Receptor alpha/Sp1
    Stephen Safe; Fiscal Year: 2006
    ..abstract_text> ..
  56. 2,3,7,8,--TCDD Effects on the Estrogenic Responses
    Stephen Safe; Fiscal Year: 2006
    ..The proposed Aims will address important mechanistic considerations on IDRE-independent inhibitory AhR-ERa crosstalk and pathways critical for inhibition of mammary tumor growth by SAhRMs. ..
  57. PHARMACOLOGY OF BOVINE PARATHYROID CA++ RECEPTORS
    Edward M Brown; Fiscal Year: 2002
    ....
  58. Biology and Drug Resistance of Candida Biofilms
    Mahmoud Ghannoum; Fiscal Year: 2005
    ..albicans biofilms. By studying biofilm model systems and applying this knowledge to the patient population, we will gain a wealth of data about the biology and drug resistance of C. albicans in biofilms. ..
  59. MECHANISM OF IL-12 INHIBITION BY CANDIDA ALBICANS
    Mahmoud Ghannoum; Fiscal Year: 2009
    ..Data obtained from these studies will lead to a better understanding of the complex immune response to CA infection and may identify novel prevention/treatment strategies for candidiasis. ..
  60. INHIBITION OF PTH SECRETION: CaR AND THE CYTOSKELETON
    Edward M Brown; Fiscal Year: 2007
    ..Phosphorylation of caveolin-1 under high Ca 2+ conditions may anchor the CaR-PTH unit to the plasma membrane, limiting PTH secretion. ..
  61. CALCIUM RECEPTOR SIGNAL RECOGNITION AND TRANSDUCTION
    Edward M Brown; Fiscal Year: 2006
    ..abstract_text> ..
  62. CA2+-RECEPTOR: IMMUNE MODULATION IN VIVO AND IN VITRO
    Edward M Brown; Fiscal Year: 2007
    ..3) To develop an animal model of activating and/or inactivating antibodies by immunization with the CaR's extracellular domain. [unreadable] [unreadable]..
  63. Electroporation and transcutaneous extraction of drugs
    SATHYANARAYANA MURTHY; Fiscal Year: 2006
    ..Further we also plan to correlate the time course of unbound ciprofloxacin in dermal ECF with that in synovial fluid determined by microdialysis in rat. [unreadable] [unreadable] [unreadable]..
  64. Improving genomic prediction models in breast cancer
    John Olson; Fiscal Year: 2005
    ....
  65. REGULATION OF DETRUSOR SMOOTH MUSCLE CONTRACTION
    PAUL RATZ; Fiscal Year: 2005
    ..Collectively, these studies will provide new insights into the cellular mechanisms regulating DSM contractions. ..
  66. Developing Biomarker-Based Prognostics In Breast Cancer
    John Olson; Fiscal Year: 2008
    ..abstract_text> ..