Genomes and Genes
Summary: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.
Publications247 found, 100 shown here
- Tetracycline resistance determinants: mechanisms of action, regulation of expression, genetic mobility, and distributionM C Roberts
Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle 98195 7238, USA
FEMS Microbiol Rev 19:1-24. 1996b>Tetracycline-resistant bacteria were first isolated in 1953 from Shigella dysenteriae, a bacterium which causes bacterial dysentery. Since then tetracycline-resistant bacterial have been found in increasing numbers of species and genera...
- Update on acquired tetracycline resistance genesMarilyn C Roberts
Department of Pathobiology, Box 357238, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA
FEMS Microbiol Lett 245:195-203. 2005This mini-review summarizes the changes in the field of bacterial acquired tetracycline resistance (tet) and oxytetracycline (otr) genes identified since the last major review in 2001...
- Global changes in Kaposi's sarcoma-associated virus gene expression patterns following expression of a tetracycline-inducible Rta transactivatorHiroyuki Nakamura
Department of Microbiology and Molecular Genetics, Division of Tumor Virology, New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
J Virol 77:4205-20. 2003..This system uses Flp-mediated efficient recombination and tetracycline-inducible expression...
- Hepatic differentiation of human bone marrow-derived mesenchymal stem cells by tetracycline-regulated hepatocyte nuclear factor 3betaKyoko Ishii
Department of Genetic Medicine and Regenerative Therapeutics, Division of Molecular and Genetic Medicine, Graduate School of Medicine, Tottori University, Yonago, Japan
Hepatology 48:597-606. 2008..In the present study, we established a tetracycline (Tet)-regulated expression system for HNF3beta in UE7T-13 BM-MSCs...
- erm(B)-carrying elements in tetracycline-resistant pneumococci and correspondence between Tn1545 and Tn6003Ileana Cochetti
Institute of Microbiology and Biomedical Sciences, Polytechnic University of Marche Medical School, Via Tronto 10 A, 60020 Ancona, Italy
Antimicrob Agents Chemother 52:1285-90. 2008..the genetic organization of erm(B)-carrying transposons of Streptococcus pneumoniae and their distribution in tetracycline-resistant clinical isolates...
- The tetracycline resistomeMaulik Thaker
Department of Biochemistry and Biomedical Sciences, Michael G DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Canada
Cell Mol Life Sci 67:419-31. 2010Resistance to tetracycline emerged soon after its discovery six decades ago...
- Abundance of six tetracycline resistance genes in wastewater lagoons at cattle feedlots with different antibiotic use strategiesNicholas Peak
Department of Civil, Environmental, and Architectural Engineering, University of Kansas, Lawrence, KS 66045, USA
Environ Microbiol 9:143-51. 2007The abundance of six tetracycline resistance genes tet(O), tet(Q), tet(W), tet(M), tet(B) and tet(L), were quantified over time in wastewater lagoons at concentrated animal feeding operations (CAFO) to assess how feedlot operation affects ..
- Tetracycline-inducible gene expression and gene deletion in Candida albicansYang-Nim Park
, , , , Germany
Eukaryot Cell 4:1328-42. 2005..We have established a system that allows induction of gene expression in C. albicans by the addition of tetracycline (Tet)...
- Conditional tetracycline-regulated expression of TGF-beta1 in liver of transgenic mice leads to reversible intermediary fibrosisElke Ueberham
University of Leipzig, Institute for Biochemistry, Germany
Hepatology 37:1067-78. 2003Based on the tetracycline-regulated gene expression system, a double-transgenic mouse model for liver fibrosis was established in which the expression of transforming growth factor beta1 (TGF-beta1) can be regulated deliberately by ..
- Silencing Mycobacterium smegmatis by using tetracycline repressorsXinzheng V Guo
Department of Microbiology and Immunology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10021, USA
J Bacteriol 189:4614-23. 2007..processes in mycobacteria, we and others have developed regulated expression systems that are repressed by a tetracycline repressor (TetR) and induced with tetracyclines, permitting the construction of conditional mutants of ..
- Multiplex PCR for the detection of tetracycline resistant genesL K Ng
National Microbiology Laboratory, Population and Public Health Branch, Winnipeg, MB, R3E 3R2, Canada
Mol Cell Probes 15:209-15. 2001Specific primer pairs were selected for the PCR amplification of 14 tetracycline resistant genes commonly found in Gram positive and Gram negative organisms...
- Targeting of a tetracycline-inducible expression system to the transcriptionally silent minichromosomes of Trypanosoma bruceiBill Wickstead
School of Biological Sciences, University of Manchester, 2.205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
Mol Biochem Parasitol 125:211-6. 2002
- The TetR family of transcriptional repressorsJuan L Ramos
Department of Plant Biochemistry and Molecular and Cellular Biology, Estacion Experimental del Zaidin, Consejo Superior de Investigaciones Cientificas, Granada, Spain
Microbiol Mol Biol Rev 69:326-56. 2005..e., TetR bound to the target operator represses tetA transcription and is released in the presence of tetracycline), or more complex, involving a series of regulatory cascades in which either the expression of the TetR family ..
- Identification of tet(M) in two Lactococcus lactis strains isolated from a Spanish traditional starter-free cheese made of raw milk and conjugative transfer of tetracycline resistance to lactococci and enterococciAna Belén Flórez
Instituto de Productos Lácteos de Asturias CSIC, Carretera de Infiesto s n, 33300 Villaviciosa, Asturias, Spain
Int J Food Microbiol 121:189-94. 2008Specific PCR and sequencing showed that a tet(M) gene was present in two tetracycline-resistant Lactococcus lactis strains isolated from a raw milk, starter-free cheese...
- Tetracycline-inducible viral interleukin-10 intraocular gene transfer, using adeno-associated virus in experimental autoimmune uveoretinitisJustine R Smith
INSERM U598, Institut Biomedical des Cordeliers, 75270 Paris, France
Hum Gene Ther 16:1037-46. 2005..Our results show that local intravitreal injection of AAV2/2 is an effective means by which to deliver immunoregulatory molecules into the eye during uveitis, a chronic human ocular disease...
- Effects of mouse strain, position of integration and tetracycline analogue on the tetracycline conditional system in transgenic miceAndrea Robertson
Imperial College School of Science, Technology and Medicine, Division of Biomedical Sciences and Clinical Sciences Centre, London, UK
Gene 282:65-74. 2002The tetracycline conditional system is a very powerful method for achieving control of gene expression in transgenic mice, allowing one to turn expression both off and on in the same animal...
- Tetracycline treatment and sex-ratio distortion: a role for Wolbachia in the moulting of filarial nematodes?M Casiraghi
Dipartimento di Patologia Animale, Universita di Milano, Milan, Italy
Int J Parasitol 32:1457-68. 2002..These bacteria are thought to be beneficial to the host nematode. Indeed, tetracycline treatments reduce the population of Wolbachia in filarial worms and have detrimental effects on the nematode...
- Tests of cytoplasmic RNA interference (RNAi) and construction of a tetracycline-inducible T7 promoter system in Trypanosoma cruziWanderson D DaRocha
Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Caixa Postal 486, Belo Horizonte, Brazil
Mol Biochem Parasitol 133:175-86. 2004..We generated a strain of T. cruzi CL-Brener in which the T7 promoter and tetracycline operator could be used to maximize tetracycline-regulated dsRNA synthesis and constructed plasmids that direct ..
- Structure and function in rhodopsin: high-level expression of rhodopsin with restricted and homogeneous N-glycosylation by a tetracycline-inducible N-acetylglucosaminyltransferase I-negative HEK293S stable mammalian cell linePhilip J Reeves
Departments of Biology and Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 99:13419-24. 2002..The tetracycline-inducible opsin expression system was assembled into this GnTI(-) HEK293S cell line...
- Expression of transgenes targeted to the Gt(ROSA)26Sor locus is orientation dependentDouglas Strathdee
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom Centre for Neuroscience Research, University of Edinburgh, Edinburgh, Scotland
PLoS ONE 1:e4. 2006..A single copy of the DNA construct can be inserted by targeting into regions of chromatin that allow the desired developmental and tissue-specific expression of the transgene...
- Tetracycline aptamer-controlled regulation of pre-mRNA splicing in yeastJulia E Weigand
Lehrstuhl fur Mikrobiologie, Friedrich Alexander Universitat Erlangen Nurnberg, Staudtstrasse 5, 91058 Erlangen, Germany
Nucleic Acids Res 35:4179-85. 2007..We apply the synthetic tetracycline (tc)-binding riboswitch to establish a gene expression system for conditional tc-dependent control of pre-mRNA ..
- Tetracycline-regulatable system to tightly control gene expression in the pathogenic fungus Candida albicansH Nakayama
Department of Mycology, Nippon Roche K K Research Center, 200 Kajiwara, Kamakura, Kanagawa 247 8530, Japan
Infect Immun 68:6712-9. 2000..To this end, we developed a convenient system to control gene expression in C. albicans by the tetracycline-regulatable (TR) promoters...
- A tetracycline-binding RNA aptamerC Berens
Institute of Microbiology and Genetics, Vienna Biocenter Dr. Bohrgasse 9/4, A-1030, Vienna, Austria
Bioorg Med Chem 9:2549-56. 2001..To study the mode of interaction of tetracycline with RNA, we isolated aptamers with high affinity to this antibiotic via in vitro selection...
- Identification of tetracycline- and erythromycin-resistant Gram-positive cocci within the fermenting microflora of an Italian dairy food productC Devirgiliis
INRAN National Research Institute on Food and Nutrition, Via Ardeatina, Rome, Italy
J Appl Microbiol 109:313-23. 2010..Microbiological and molecular analysis of antibiotic resistance in Gram-positive cocci derived from the Italian PDO (Protected Designation of Origin) dairy food product Mozzarella di Bufala Campana...
- Brugia pahangi and Wolbachia: the kinetics of bacteria elimination, worm viability, and host responses following tetracycline treatmentSharon R Chirgwin
Department of Pathobiological Science, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA
Exp Parasitol 103:16-26. 2003..b>Tetracycline has been used to cure filariae of Wolbachia, as a novel means of chemotherapeutic treatment for both ocular and ..
- The 27.8-kb R-plasmid pTET3 from Corynebacterium glutamicum encodes the aminoglycoside adenyltransferase gene cassette aadA9 and the regulated tetracycline efflux system Tet 33 flanked by active copies of the widespread insertion sequence IS6100Andreas Tauch
Degussa AG, Kantstrasse 2, D 33790 Halle Künsebeck, Germany
Plasmid 48:117-29. 2002..8-kb R-plasmid pTET3 from Corynebacterium glutamicum LP-6 which encodes streptomycin, spectinomycin, and tetracycline resistance...
- Inducible endothelial cell-specific gene expression in transgenic mouse embryos and adult miceUrban Deutsch
Theodor Kocher Institute, University of Bern, Bern, Switzerland
Exp Cell Res 314:1202-16. 2008..These transgenic model systems provide versatile tools for the TET-regulated manipulation of endothelial cell-specific gene expression in the entire embryonic vasculature and distinct vascular beds in adult mice...
- Development of a BAC vector for integration-independent and tight regulation of transgenes in rodents via the Tet systemKai Schonig
Department of Molecular Biology, Central Institute of Metal Health and Heidelberg University, Medical Faculty Mannheim, J5, 68159, Mannheim, Germany
Transgenic Res 20:709-20. 2011..Similarly, tetracycline (Tet) controlled transcription units most commonly used for conditional transgene expression in mice are ..
- Proteomic analysis of the sarcosine-insoluble outer membrane fraction of Pseudomonas aeruginosa responding to ampicilin, kanamycin, and tetracycline resistanceXuanxian Peng
Center for Proteomics, Department of Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, People's Republic of China
J Proteome Res 4:2257-65. 2005..aeruginosa responding to ampicilin, kanamycin and tetracycline resistances...
- Ligand-induced conformational capture of a synthetic tetracycline riboswitch revealed by pulse EPRDorith Wunnicke
Fachbereich Physik, Universitat Osnabruck, 49069 Osnabruck, Germany
RNA 17:182-8. 2011..spectroscopy combined with site-directed spin labeling was used to elucidate the conformational transition of a tetracycline aptamer upon ligand binding...
- An improved tetracycline-inducible expression vector for Staphylococcus aureusRebecca M Corrigan
Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
Plasmid 61:126-9. 2009The tetracycline-inducible expression vector pALC2073 allowed high level expression of the cloned sasG gene but repression by uninduced cells was leaky...
- Brugia malayi gene expression in response to the targeting of the Wolbachia endosymbiont by tetracycline treatmentElodie Ghedin
University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
PLoS Negl Trop Dis 3:e525. 2009..Elimination of the endosymbiont leads to sterilization of the adult female. Previous biochemical and genetic studies have established that communication with its endobacterium is essential for survival of the worm...
- Tetracycline-chelated Mg2+ ion initiates helix unwinding in Tet repressor inductionP Orth
Institut fur Kristallographie, Freie Universitat Berlin, Germany
Biochemistry 38:191-8. 1999The homodimeric tetracycline repressor (TetR) regulates resistance to the antibiotic tetracycline at the transcriptional level. TetR binds in the absence of Tc to palindromic operator sequences utilizing two helix-turn-helix (HTH) motifs...
- Use of a nonmedicated dietary supplement correlates with increased prevalence of streptomycin-sulfa-tetracycline-resistant Escherichia coli on a dairy farmArtashes R Khachatryan
Department of Veterinary Microbiology and Pathology, 402 Bustad Hall, Pullman, WA 99164-7040, USA
Appl Environ Microbiol 72:4583-8. 2006..Between 2001 and 2004 the prevalence of fecal E. coli strains resistant to streptomycin, sulfadiazine, and tetracycline (SSuT strains) declined from 59.2% to 26.1% in the calf population...
- Tet(M)-promoted release of tetracycline from ribosomes is GTP dependentV Burdett
Department of Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Bacteriol 178:3246-51. 1996..factor G (EF-G), interacts with the protein biosynthetic machinery to render this process resistant to tetracycline in vivo and in vitro...
- Prevalence of Helicobacter pylori resistance to metronidazole, clarithromycin, amoxycillin, tetracycline and trovafloxacin in The NetherlandsY J Debets-Ossenkopp
Department of Clinical Microbiology and Infection Control, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
J Antimicrob Chemother 43:511-5. 1999..We report the prevalence rates of H. pylori resistance to metronidazole, clarithromycin, amoxycillin, tetracycline and trovafloxacin in The Netherlands. A total of 231 H...
- Pretreatment antibiotic resistance in Helicobacter pylori infection: results of three randomized controlled studiesG Realdi
Department of Internal Medicine, University of Sassari, Italy
Helicobacter 4:106-12. 1999..The aim of this study was to evaluate the relation between pretreatment antibiotic resistance and outcome by using six different treatment regimens for H. pylori infection...
- Sphingobacterium sp. strain PM2-P1-29 harbours a functional tet(X) gene encoding for the degradation of tetracyclineS Ghosh
Department of Civil Engineering, University of Minnesota, Minneapolis, 55455 0116, USA
J Appl Microbiol 106:1336-42. 2009..which is curious because tet(X) encodes for a NADP-dependent monooxygenase that requires oxygen to degrade tetracycline. In this study, we characterized a tetracycline resistant, aerobic, Gram-negative Sphingobacterium sp...
- The induction of folding cooperativity by ligand binding drives the allosteric response of tetracycline repressorSean E Reichheld
Department of Biochemistry and Molecular Genetics, University of Toronto, Toronto, ON, Canada
Proc Natl Acad Sci U S A 106:22263-8. 2009b>Tetracycline (Tc) repressor (TetR) undergoes an allosteric transition upon interaction with the antibiotic, Tc, that abrogates its ability to specifically bind its operator DNA...
- New Tn916-related elements causing erm(B)-mediated erythromycin resistance in tetracycline-susceptible pneumococciIleana Cochetti
Institute of Microbiology and Biomedical Sciences, Polytechnic University of Marche Medical School, 60020 Ancona, Italy
J Antimicrob Chemother 60:127-31. 2007To analyse the as yet unexplored genetic elements encoding erm(B)-mediated erythromycin resistance in tetracycline-susceptible pneumococci.
- Decreased nanobacteria levels and symptoms of nanobacteria-associated interstitial cystitis/painful bladder syndrome after tetracycline treatmentQing Hua Zhang
Urological Research Institute of PLA, Southwest Hospital, Third Military Medical University, Chongqing, 400038, People s Republic of China
Int Urogynecol J 21:103-9. 2010....
- Developing tTA transgenic rats for inducible and reversible gene expressionHongxia Zhou
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Int J Biol Sci 5:171-81. 2009..conditional expression of desired genes in rats, we generated several lines of the transgenic rats carrying the tetracycline-controlled transactivator (tTA) gene...
- Resistance to tetracycline, macrolide-lincosamide-streptogramin, trimethoprim, and sulfonamide drug classesMarilyn C Roberts
Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle 98195, USA
Mol Biotechnol 20:261-83. 2002..In this article, we will examine the genes which confer resistance to tetracycline, macrolide-lincosamide-streptogramin (MLS), trimethoprim, and sulfonamide.
- Tetracycline resistance in Escherichia coli and persistence in the infantile colonic microbiotaNahid Karami
Department of Clinical Bacteriology, Goteborg University, Guldhedsgatan 10A, SE 413 46 Goteborg, Sweden
Antimicrob Agents Chemother 50:156-61. 2006..We assessed the carriage of tetracycline resistance genes, persistence in the microbiota, fecal population counts and virulence factor genes in 309 ..
- A practical, enantioselective synthetic route to a key precursor to the tetracycline antibioticsJason D Brubaker
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Org Lett 9:3523-5. 2007A practical, enantioselective synthetic route to a key precursor to the tetracycline antibiotics is reported. The route proceeds in nine steps (21% yield) from the commercial substance methyl 3-hydroxy-5-isoxazolecarboxylate...
- Changes in immune parameters and their correction in human cases of tick-borne encephalitisA V Atrasheuskaya
State Research Centre of Virology and Biotechnology (Vector, Koltsovo, Novosibirsk Region, Russia
Clin Exp Immunol 131:148-54. 2003..In this study, we investigated the potential clinical benefits of administering tetracycline hydrochloride to patients hospitalized due to suspected TBEV infection presenting with fever and evidence of a ..
- Molecular investigation of macrolide and Tetracycline resistances in oral bacteria isolated from Tunisian childrenBochra Kouidhi
Laboratoire d Analyses, Traitement et Valorisation des Polluants de l Environnement et des Produits, Faculté de Pharmacie de Monastir, Biologie clinique, Rue Avicenne, 5000 Monastir, Tunisie
Arch Oral Biol 56:127-35. 2011..This study aims to investigate the antibiotic susceptibility of strains isolated from the oral cavity of Tunisian children...
- Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell sizeNao Hosokawa
Department of Bioregulation and Metabolism, Tokyo Metropolitan Institute of Medical Science, 3-18-22 Honkomagome, Tokyo 113-8613, Japan
FEBS Lett 580:2623-9. 2006..The generated cell lines will be useful reagents for future mechanistic studies into the regulation and physiologic significance of autophagy...
- Development, validation, and application of PCR primers for detection of tetracycline efflux genes of gram-negative bacteriaR I Aminov
Department of Animal Sciences, University of Illinois at Urbana Champaign USDA Agricultural Research Service, Urbana, Illinois 61801, USA
Appl Environ Microbiol 68:1786-93. 2002Phylogenetic analysis of tetracycline resistance genes, which confer resistance due to the efflux of tetracycline from the cell catalyzed by drug:H(+) antiport and share a common structure with 12 transmembrane segments (12-TMS), ..
- pTcINDEX: a stable tetracycline-regulated expression vector for Trypanosoma cruziMartin C Taylor
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
BMC Biotechnol 6:32. 2006..To this end we report the development of a stable tetracycline-dependent expression vector applicable to this parasite and describe in detail the parameters of the system.
- A tetracycline-regulated adenovirus encoding dominant-negative caspase-9 is regulated in rat brain and protects against neurotoxin-induced cell death in vitro, but not in vivoAllison D Ebert
Children s Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60614, USA
Exp Neurol 191:S80-94. 2005..In this study, we determined that a tetracycline-regulated adenovirus harboring a dominant-negative form of caspase-9 (Casp9DN) and the marker gene, enhanced ..
- Distribution of tetracycline and streptomycin resistance genes and class 1 integrons in Enterobacteriaceae isolated from dairy and nondairy farm soilsVelusamy Srinivasan
Department of Animal Science and the Food Safety Center of Excellence, The University of Tennessee, Knoxville, TN 37996, USA
Microb Ecol 55:184-93. 2008The prevalence of selected tetracycline and streptomycin resistance genes and class 1 integrons in Enterobacteriaceae (n = 80) isolated from dairy farm soil and nondairy soils was evaluated...
- A novel tetracycline labeling schedule for longitudinal evaluation of the short-term effects of anabolic therapy with a single iliac crest bone biopsy: early actions of teriparatideRobert Lindsay
Clinical Research Center, New York State Department of Health, Helen Hayes Hospital, West Haverstraw, New York 10993, USA
J Bone Miner Res 21:366-73. 2006We describe a quadruple tetracycline labeling method that allows longitudinal assessment of short-term changes in bone formation in a single biopsy...
- Structural basis for specific, high-affinity tetracycline binding by an in vitro evolved aptamer and artificial riboswitchHong Xiao
Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
Chem Biol 15:1125-37. 2008The tetracycline aptamer is an in vitro selected RNA that binds to the antibiotic with the highest known affinity of an artificial RNA for a small molecule (Kd approximately 0.8 nM)...
- Tight positive regulation of transgene expression by a single adenovirus vector containing the rtTA and tTS expression cassettes in separate genome regionsHiroyuki Mizuguchi
Division of Cellular and Gene Therapy Products, National Institute of Health Sciences, Tokyo 158 8501, Japan
Hum Gene Ther 14:1265-77. 2003We previously developed single adenovirus (Ad) vectors that contained the components for a tetracycline-regulatable gene-expression system in the E1 and E3 deletion regions, and showed that the Ad vectors containing the tet-on system ..
- Optimisation and characterisation of bioadhesive controlled release tetracycline microspheresS Govender
School of Pharmacy and Pharmacology, University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa
Int J Pharm 306:24-40. 2005A Box-Behnken experimental design was employed to statistically optimise the formulation parameters of a tetracycline microsphere preparation for maximum bioadhesivity and controlled drug release...
- A recombinant Escherichia coli sensor strain for the detection of tetracyclinesM T Korpela
Department of Biotechnology, University of Turku, Finland
Anal Chem 70:4457-62. 1998A bioluminescent Escherichia coli K-12 strain for the specific detection of the tetracycline group of antibiotics is described...
- Biodegradable microparticles for sustained delivery of tetracycline to the periodontal pocket: formulatory and drug release studiesE Esposito
Department of Pharmaceutical Sciences, Ferrara University, Italy
J Microencapsul 14:175-87. 1997This paper describes the production and characterization of biodegradable microparticles containing tetracycline, designed for periodontal disease therapy...
- Changes in tetracycline susceptibility of enteric bacteria following switching to nonmedicated milk replacer for dairy calvesJohn B Kaneene
Center for Comparative Epidemiology, Michigan State University, East Lansing, Michigan 48824 1314, USA
J Clin Microbiol 46:1968-77. 2008..to determine if discontinuing use of calf milk replacer medicated with oxytetracycline results in increased tetracycline susceptibility in Salmonella and Campylobacter spp. and Escherichia coli in dairy calves over a 12-month period...
- Electrochemical aptasensor for tetracycline detectionYoon Jin Kim
School of Life Sciences and Biotechnology, Korea University, Anam Dong, Seongbuk gu, Seoul 136 701, Republic of Korea
Bioprocess Biosyst Eng 33:31-7. 2010An electrochemical aptasensor was developed for the detection of tetracycline using ssDNA aptamer that selectively binds to tetracycline as recognition element...
- Tetracycline aspiration. Case report and review of the literatureK M Sundar
Department of Medicine, University of Utah School of Medicine, and Pulmonary Division, LDS Hospital, 8th Avenue and C Street, Salt Lake City, UT 84143, USA
Respiration 68:416-9. 2001A 74-year-old woman presented with a 2-day history of cough, dyspnea and wheezing following aspiration of a tetracycline tablet...
- In vitro activity of tigecycline, tetracycline and fluoroquinolones against Brucella melitensisS Kilic
Refik Saydam National Hygiene Center, Department of Communicable Diseases Research Ankara, Turkey
J Chemother 20:33-7. 2008..the in vitro susceptibility of 60 Brucella melitensis isolates obtained from blood and fluids to tigecycline, tetracycline and three quinolones (ciprofloxacin, levofloxacin, moxifloxacin)...
- Tetracycline-resistant Chlamydia suis isolates in ItalyA Di Francesco
Department of Veterinary Public Health and Animal Pathology, Faculty of Veterinary Medicine, University of Bologna, Bologna, Italy
Vet Rec 163:251-2. 2008
- Sustained tetracycline-regulated transgene expression in vivo in rat retinal ganglion cells using a single type 2 adeno-associated viral vectorSebastien Folliot
, CHU-Hotel Dieu, Bat. J. Monnet, 30 Avenue J. Monnet, 44035 Nantes Cedex 01, France
J Gene Med 5:493-501. 2003..The purpose of our study was to evaluate whether a single recombinant AAV-2 (rAAV) encoding for a tetracycline (Tet)-regulated destabilized reporter gene could provide quantitative profiles of gene regulation targeted to ..
- Susceptibility to tetracycline and erythromycin of Lactobacillus paracasei strains isolated from traditional Italian fermented foodsRoberta Comunian
AGRIS Sardegna, Dipartimento per la Ricerca nelle Produzioni Animali, Olmedo SS, Italy
Int J Food Microbiol 138:151-6. 2010..Lactobacillus paracasei, isolated from Italian fermented products coming from different geographical areas, to tetracycline and erythromycin, two antimicrobials widely used in clinical and animal therapy...
- Tetracycline-associated transcriptional regulation of transfer genes of the Bacteroides conjugative transposon CTnDOTRobert T Jeters
Department of Microbiology, 601 S Goodwin Ave, Rm B103, University of Illinois, Urbana, IL 61801
J Bacteriol 191:6374-82. 2009..A distinctive feature of CTnDOT is that its excision and transfer are stimulated by tetracycline. Regulation of the genes responsible for excision has been described previously...
- Quantification of virus-envelope-mediated cell fusion using a tetracycline transcriptional transactivator: fusion does not correlate with syncytium formationWu Ou
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Building 4 Room 336, 4 Center Drive, MSC 4060, Bethesda, MD 20892 0460, USA
Virology 324:263-72. 2004..We developed a new, quantitative cell fusion assay based on the tetracycline-controlled transactivator (tTA)-induced expression of a luciferase reporter gene...
- Tetracycline prevents Aβ oligomer toxicity through an atypical supramolecular interactionCristina Airoldi
Department of Biotechnology and Biosciences, University of Milano Bicocca, P zza della Scienza 2, 20126, Milan, Italy
Org Biomol Chem 9:463-72. 2011The antibiotic tetracycline was reported to possess an anti-amyloidogenic activity on a variety of amyloidogenic proteins both in in vitro and in vivo models...
- Topical minocycline and tetracycline rinses in treatment of recurrent aphthous stomatitis: a randomized cross-over studyMeir Gorsky
Department of Oral Pathology and Oral Medicine, The Maurice and Gabriella Goldschleger School of Dental Medicine, Tel Aviv University, Israel
Dermatol Online J 13:1. 2007..We assessed minocycline and tetracycline oral rinses in patients with frequent episodes of RAS in a clinical randomized crossover trial...
- Mapping of the second tetracycline binding site on the ribosomal small subunit of E.coliMaria M Anokhina
Department of Chemistry, Moscow State University, 119992 Moscow, Russian Federation
Nucleic Acids Res 32:2594-7. 2004b>Tetracycline blocks stable binding of aminoacyl-tRNA to the bacterial ribosomal A-site. Various tetracycline binding sites have been identified in crystals of the 30S ribosomal small subunit of Thermus thermophilus...
- Investigation of erythromycin and tetracycline resistance genes in methicillin-resistant staphylococciNurittin Ardic
Gulhane Military Medical Academy, Haydarpasa Training Hospital, Department of Microbiology and Clinical Microbiology, 81327 Uskudar, Istanbul, Turkey
Int J Antimicrob Agents 26:213-8. 2005In this study, erythromycin [erm(A) and erm(C)] and tetracycline [tet(K) and tet(M)] resistance genes were investigated by multiplex polymerase chain reaction (PCR) in a total of 56 methicillin-resistant (mecA+) staphylococcal hospital ..
- Specific binding of divalent metal ions to tetracycline and to the Tet repressor/tetracycline complexGottfried J Palm
Institut fur Biochemie, Universitat Greifswald, Felix Hausdorff Strasse 4, 17489, Greifswald, Germany
J Biol Inorg Chem 13:1097-110. 2008..The Tet repressor, TetR, is the molecular switch for tetracycline resistance determinants in gram-negative bacteria...
- Performance of a tetracycline-responsive transactivator system for regulating transgenes in the oomycete Phytophthora infestansHoward S Judelson
Department of Plant Pathology, University of California, Riverside, CA 92521, USA
Curr Genet 51:297-307. 2007..Here the adaptation of the reverse tetracycline transactivator (rtTA) system to P. infestans is described...
- Gamma globulin, Evan's blue, aprotinin A PLA2 inhibitor, tetracycline and antioxidants protect epithelial cells against damage induced by synergism among streptococcal hemolysins, oxidants and proteinases: relation to the prevention of post-streptococcal I Ginsburg
Department of Oral Biology, Hebrew University Hadassah, School of Dental Medicine, Jerusalem, Israel
FEMS Immunol Med Microbiol 22:247-56. 1998..inhibited either by micromolar amounts of gamma globulin, and Evan's blue which neutralized SLO activity, by tetracycline, trasylol (aprotinin), epsilon amino caproic acid and by soybean trypsin inhibitor, all proteinase inhibitors ..
- Geographical difference in antimicrobial resistance pattern of Helicobacter pylori clinical isolates from Indian patients: Multicentric studyS P Thyagarajan
Departments of Microbiology and Gastroenterology, Dr ALM Post Graduate Institute of Basic Medical Sciences and Government General Hospital, Chennai, India
J Gastroenterol Hepatol 18:1373-8. 2003..pylori treatment regimen to be used in these areas...
- Molecular analysis of tetracycline-resistant gonococci: rapid detection of resistant genotypes using a real-time PCR assayStefania Starnino
Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
FEMS Microbiol Lett 286:16-23. 2008The aim of this study was to examine tetracycline-resistant gonococci and to set up a real-time PCR method to identify, in the same assay, both the chromosomally and the plasmid-mediated tetracycline-resistant genotypes...
- Tet 42, a novel tetracycline resistance determinant isolated from deep terrestrial subsurface bacteriaMindy G Brown
Department of Biomedical Sciences, Florida State University College of Medicine, 1115 West Call Street, Tallahassee, FL 32306 4300, USA
Antimicrob Agents Chemother 52:4518-21. 2008Tet 42, a novel tetracycline resistance determinant from deep subsurface bacteria, was characterized and found to have a 30% sequence similarity to TetA(Z)...
- Antimicrobial resistance of Helicobacter pylori isolates from Iranian adults and childrenFarideh Siavoshi
Department of Microbiology, Faculty of Sciences, Tehran University, PO Box 14155 6455, Tehran, Iran
Arch Iran Med 9:308-14. 2006..of 2001 through 2004 to find out whether their susceptibilities to metronidazole, clarithromycin, amoxicillin, tetracycline, and furazolidone differ between the two groups or have changed compared with the results from our previous ..
- A versatile nonviral vector system for tetracycline-dependent one-step conditional induction of transgene expressionK Inoue
Department of Molecular Biology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
Gene Ther 16:1383-94. 2009In this study, we describe a novel self-contained, nonviral vector system for the rapid development of tetracycline (Tet)-inducible transgene expression systems in mammalian cell lines...
- A combination of sbmA and tolC mutations in Escherichia coli K-12 Tn10-carrying strains results in hypersusceptibility to tetracyclineRicardo E de Cristóbal
Departamento de Bioquimica de la Nutricion, Instituto Superior de Investigaciones Biologicas, Consejo Nacional de Investigaciones Científicas y Técnicas Universidad Nacional de Tucumán, 4000 San Miguel de Tucuman, Tucuman, Argentina
J Bacteriol 190:1491-4. 2008Previously, we demonstrated that Escherichia coli tolC mutations reduce the high-level resistance to tetracycline afforded by the transposon Tn10-encoded TetA pump from resistance at 200 microg/ml to resistance at 40 microg/ml...
- Tetracycline rapidly reaches all the constituent cells of uropathogenic Escherichia coli biofilmsG Stone
Drew U, Madison, NJ
Antimicrob Agents Chemother 46:2458-61. 2002We have developed a method for visualizing Escherichia coli cells that are exposed to tetracycline in a biofilm, based on a previous report that liposomes containing the E. coli TetR(B) protein fluoresce when exposed to this antibiotic...
- The effects of residual tetracycline on soil enzymatic activities and plant growthX Wei
Croucher Institute for Environmental Sciences, Hong Kong Baptist University, Hong Kong, P R China
J Environ Sci Health B 44:461-71. 2009A pot trial was carried out to investigate the adverse effects of tetracycline (TC) on soil microbial communities, microbial activities, and the growth of ryegrass (Lolium perenne L)...
- Fast set-up of doxycycline-inducible protein expression in human cell lines with a single plasmid based on Epstein-Barr virus replication and the simple tetracycline repressorMarkus Bach
Department of Pharmacology, University of Cologne, Germany
FEBS J 274:783-90. 2007..and efficient episomal propagation in human cell lines, a cassette for continuous expression of the simple tetracycline repressor, and a cytomegalovirus-type 2 tetracycline operator (tetO2)-tetO2 promoter...
- Gene in the major cotransduction gap of the Escherichia coli K-12 linkage map required for the expression of chromosomal resistance to tetracycline and other antibioticsA M George
J Bacteriol 155:541-8. 1983In Escherichia coli K-12, amplifiable resistance to tetracycline, chloramphenicol, and other unrelated antibiotics was mediated by at least four spatially separated loci...
- Controlled local delivery of tetracycline with polymer strips in the treatment of periodontitisLynn R Friesen
Department of Periodontics, University of Missouri-Kansas City, School of Dentistry, 64108, USA
J Periodontol 73:13-9. 2002..The primary purpose of this study was to evaluate the efficacy of tetracycline strips administered singly or in multiples in conjunction with root planing, versus root planing alone, or to ..
- Proteomic analysis of outer membrane proteins from Acinetobacter baumannii DU202 in tetracycline stress conditionSung Ho Yun
Proteome Research Team, Korea Basic Science Institute, Daejeon, 305 806, Republic of Korea
J Microbiol 46:720-7. 2008..A. baumannii DU202 is a multi-drug resistant strain, and is highly resistant to tetracycline (MIC>1,024 micro/ml). The surface proteome of A...
- Prevalence of Helicobacter pylori resistance to metronidazole, clarithromycin, amoxycillin and tetracycline in LebanonAla I Sharara
Department of Internal Medicine, Box 11 0236 16B, American University of Beirut Medical Center, Beirut, Lebanon
Int J Antimicrob Agents 19:155-8. 2002..Fifty-four consecutively recovered H. pylori isolates were tested against metronidazole, clarithromycin, tetracycline and amoxycillin using the epsilometer test. Resistance to metronidazole (MIC > 8 mg/l) was found in 29...
- Effects of oxacillin and tetracycline on autolysis, autolysin processing and atl transcription in Staphylococcus aureusNagender Ledala
Microbiology Group, Department of Biological Sciences, Illinois State University, Normal, IL 61790-4120, USA
Int J Antimicrob Agents 27:518-24. 2006..The objective of our study was to examine the effect of oxacillin, chloramphenicol and tetracycline on autolysis, peptidoglycan hydrolase profiles and transcription of atl encoding the major S...
- Molecular basis and transferability of tetracycline resistance in Enterococcus italicus LMG 22195 from fermented milkMiriam Zago
Agriculture Research Council, Research Centre for Fodder Crop and Dairy Productions CRA FLC, Lodi, Italy
Int J Food Microbiol 142:234-6. 2010A tetracycline-resistant Enterococcus italicus strain from fermented milk, LMG 22195, was found to contain a tet(S) gene located on a plasmid of approximately 20kb...
- Lab-on-valve system integrating a chemiluminescent entity and in situ generation of nascent bromine as oxidant for chemiluminescent determination of tetracyclineMei Yang
Research Center for Analytical Sciences, Northeastern University, Box 332, Shenyang 110004, China
Anal Chem 78:5900-5. 2006..of the LOV for in situ oxidation of KBr and generation of bromine as oxidant for the bromine-hydrogen peroxide-tetracycline (TC) chemiluminescent reaction...
- Phenotypic characterization of the binding of tetracycline to human serum albuminZhenxing Chi
Shandong Provincial Key Laboratory of Water Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Shandong University, China America CRC for Environment and Health, Shandong Province, 27 Shanda South Road, Jinan 250100, People s Republic of China
Biomacromolecules 12:203-9. 2011Because of the widely usage of the veterinary drug tetracycline (TC), its residue exist extensively in the environment (e.g., animal food, soils, surface water, and groundwater) and can enter human body, being potential harmful...
- Helicobacter pylori: prevalence of antimicrobial resistance in clinical isolatesC Hooton
Department of Microbiology, Cork University Hospital, Ireland
Br J Biomed Sci 63:113-6. 2006..determine the in vitro susceptibility of Helicobacter pylori to clarithromycin, metronidazole, amoxycillin and tetracycline, the four antibiotics commonly used in eradication therapies...
- Antibiotic resistance in an in vitro subgingival biofilm modelM J Sedlacek
Department of Oral Biology, University of Florida, Gainesville, FL 32610 0424, USA
Oral Microbiol Immunol 22:333-9. 2007..The purpose of this study was to utilize an in vitro biofilm model of subgingival plaque to investigate resistances in subgingival biofilm communities to antibiotics commonly used as adjuncts to periodontal therapy...
- Airborne multidrug-resistant bacteria isolated from a concentrated swine feeding operationAmy Chapin
Johns Hopkins Bloomberg School of Public Health, Department of Environmental Health Sciences, Baltimore, Maryland 21205-2103, USA
Environ Health Perspect 113:137-42. 2005..level using standard biochemical tests and analyzed for resistance to erythromycin, clindamycin, virginiamycin, tetracycline, and vancomycin using the agar dilution method...
- [Susceptibility of 36 Helicobacter pylori clinical isolates to four first-line antibiotics and virulence factors]J Díaz-Regañón
Servicio de Microbiologia, Hospital Universitario de la Princesa, Madrid, Spain
Rev Esp Quimioter 19:34-8. 2006..clarithromycin is increasing, especially in children, although they are still susceptible to amoxicillin and tetracycline. In order to determine the susceptibility pattern to these antibiotics 36 H...
- Resistance rate to antibiotics of Helicobacter pylori isolates in eastern TaiwanChi Tan Hu
Division of Gastroenterology, Buddhist Tzu Chi General Hospital, Taipei, Taiwan
J Gastroenterol Hepatol 22:720-3. 2007..pylori) strains resistant to metronidazole, clarithromycin and amoxicillin is increasing worldwide. The aim of this study was to determine the antibiotic susceptibility patterns in H. pylori strains isolated from eastern Taiwan...
- Nasal antibiotic-resistant Propionibacterium acnes carriage in acne vulgaris patients in TurkeyCagri Ergin
J Dermatol 33:899-901. 2006
- Susceptibility of bacteria from feline and canine urinary tract infections to doxycycline and tetracycline concentrations attained in urine four hours after oral dosageB J Wilson
Faculty of Veterinary Science, The University of Sydney, New South Wales, 2006
Aust Vet J 84:8-11. 2006OBJECTIVES: To measure urinary concentrations of doxycycline in cats and dogs and tetracycline in dogs 4 h after conventional oral dosing and determine whether these antibiotics were present in sufficient concentrations to be effective ..
- Distribution and molecular analysis of mef(A)-containing elements in tetracycline-susceptible and -resistant Streptococcus pyogenes clinical isolates with efflux-mediated erythromycin resistanceAndrea Brenciani
Institute of Microbiology and Biomedical Sciences, Marche Polytechnic University, 60131 Ancona, Italy
J Antimicrob Chemother 54:991-8. 2004..To further characterize a tet(O)-mef(A) element...
- Comparison of E-test and disk diffusion assay to evaluate resistance of Helicobacter pylori isolates to amoxicillin, clarithromycin, metronidazole and tetracycline in Costa RicaLore Lang
, , Universidad de Costa Rica, 2060 Ciudad Universitaria Rodrigo Facio, San Jos, Costa Rica
Int J Antimicrob Agents 24:572-7. 2004..3% to clarithromycin and 5.3% to amoxicillin. No isolate was resistant to tetracycline. Multiple resistance was found in 4.3% of the isolates. H...
- Doxycycline- and tetracycline-regulated transcriptional silencer enhance the expression level and transactivating performance of rtTAJen-Feng Lai
Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, No. 7 Chung-Shan S. Road, Taipei, 100 Taiwan
J Gene Med 6:1403-13. 2004BACKGROUND: The tetracycline-regulated transcriptional silencer (tTS) has been demonstrated to mitigate leaky expression of the tetracycline-inducible promoter under uninduced condition, and, when conjugated with reverse-type tetracycline-..
- TRANSCRIPTIONAL CONTROL OF MAMMALIAN BRAIN DEVELOPMENTEseng Lai; Fiscal Year: 2001..differentiation, the PI has shown, using a mink lung cell line where BF-1 expression is under control of tetracycline withdrawal, that the presence of BF-1 promotes entry into S phase in the presence of TGF-b...
- Peptide Derivatives to treat Urinary Tract InfectionsLaszlo Otvos; Fiscal Year: 2003..Pyrrhocoricin and its designed analogs kill (-lactam-, tetracycline- and aminoglycoside-resistant Escherichia coli, Klebsiella pneumoniae, Salmonella typhimurium, and Haemophilus ..
- NUCLEIC ACID PROBES OF RIBOSOMAL STRUCTURE AND FUNCTIONBARRY COOPERMAN; Fiscal Year: 2003..Many antibiotics in current clinical use, such as tetracycline, erythromycin and other macrolides, neomycin and other aminoglycosides, and chloramphenicol target ribosomes as ..
- Enhancement of antimicrobics by electrical currentRobin Patel; Fiscal Year: 2007..of electric current can enhance the killing of biofilm bacteria by non-aminoglycoside, non-quinolone, non-tetracycline antimicrobics and whether the bioelectric effect is generalizable to Staphylococcus aureus...
- PENICILLIN RESISTANT NEISSERIA GONORRHOEAE (CMRNG)Robert Nicholas; Fiscal Year: 2000..Gonococcal resistance to tetracycline has also dramatically risen...
- Glutathione and Lung FibrosisRui Ming Liu; Fiscal Year: 2010..Increasing GSH in lung ELF in tetracycline inducible lung specific glutamate cysteine ligase (GCL) transgenic mice also inhibits TGF-(-induced PAI-1 ..
- CONJUGAL TRANSFER OF BACTEROIDES ANTIBIOTIC RESISTANCESAbigail Salyers; Fiscal Year: 1999..Virtually all clinical isolates are now resistant to tetracycline whereas tetracycline resistance was once uncommon...
- MRI AND MRS OF HORMONAL INDUCED CHANGES IN BREAST CANCERHadassa Degani; Fiscal Year: 2007..a stably transfected human c-myc gene, whose expression is stringently controlled by the bacterial reverse tetracycline transcription activator protein...
- Molecular mechanism of immune evasion by Yersinia pestisTomas Mustelin; Fiscal Year: 2003..Although several vaccines exist, and Yersinia usually is sensitive to streptomycin and tetracycline type antibiotics, the pneumonic form of the disease is difficult to treat and still often results in death...
- Alteration of circadian rhythm and sleep by HIV protein TatJian Ding; Fiscal Year: 2009..To assess the long term effect of Tat to the sleep and circadian timing system, we used the tetracycline-dependent and brain (GFAP) specific Tat transgenic mice...
- Molecular Targets in Peptidoglycan SynthesisChristopher Davies; Fiscal Year: 2010..Penicillin and tetracycline are no longer used to treat gonococcal infections due to the emergence of resistant strains of N. gonorrhoeae...
- SURFACE ANTIGENS OF ORAL BACTEROIDES SPECIESAnn Progulske Fox; Fiscal Year: 1993..homologous recombination between the wild-type and inactivated HA genes has occurred should be resistant to tetracycline. All tetracycline resistant colonies will be tested for the presence of defective HA gene by immunological and ..
- Molecular Targets in Peptidoglycan SynthesisChristopher Davies; Fiscal Year: 2009..Penicillin and tetracycline are no longer used to treat gonococcal infections due to the emergence of resistant strains of N. gonorrhoeae...
- Structural basis of tetracycline resistance by efflux pump TetLDa Neng Wang; Fiscal Year: 2010..tetracyclines is mediated by membrane transporter proteins that catalyze efflux of tetracyclines in the form of tetracycline-magnesium complex. The structural basis for substrate recognition by such efflux proteins is poorly understood...
- Development and Plasticity of a Retinotectal SystemMu ming Poo; Fiscal Year: 2010..or mutated forms of Ephrin-B1 or EphB2 in a few RGCs or tectal cells by electroporation, and (3) global tetracycline-induced transgenic expression of these proteins in either all presynaptic RGCs or all postsynaptic tectal cells...
- STRUCTURE AND GENETIC CONTROL OF COLICINESDonald Helinski; Fiscal Year: 2005..Plasmid RK2 specifies resistance to the antibiotics ampicillin, tetracycline and kanamycin, and will replicate and is stably maintained in a wide range of Gram-negative bacteria...
- INTESTINAL LIPOPROTEINS IN THE NEONATEDennis Black; Fiscal Year: 2007..Further studies are proposed using an AAV vector expression system, tetracycline regulatable gene expression technology and subcellular fractionation techniques to test the main hypothesis ..