methacycline

Summary

Summary: A broad-spectrum semisynthetic antibiotic related to TETRACYCLINE but excreted more slowly and maintaining effective blood levels for a more extended period.

Top Publications

  1. ncbi Development and validation of an HPLC confirmatory method for the determination of seven tetracycline antibiotics residues in milk according to the European Union Decision 2002/657/EC
    Victoria F Samanidou
    Laboratory of Analytical Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece
    J Sep Sci 30:2430-9. 2007
  2. doi Inhibition of Epithelial-to-Mesenchymal Transition and Pulmonary Fibrosis by Methacycline
    Ying Xi
    1 Pulmonary and Critical Care Division and Department of Medicine, and
    Am J Respir Cell Mol Biol 50:51-60. 2014
  3. doi Binding of methacycline to human serum albumin at subdomain IIA using multispectroscopic and molecular modeling methods
    Chengyu Dong
    Collecge of Life and Environmental Science, Minzu University of China, Beijing, 100081, China
    Luminescence 28:933-41. 2013
  4. ncbi Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines
    Kenneth N Agwuh
    Department of Medical Microbiology, Old Medical School, Leeds General Infirmary Great George Street, Leeds LS1 2EX, UK
    J Antimicrob Chemother 58:256-65. 2006
  5. doi Evaluation of the antioxidant activity of tetracycline antibiotics in vitro
    Aleksandra Kładna
    Department of Medical History and Ethics, Pomeranian Medical Academy, Ul Rybacka 1, 70 204, Szczecin, Poland
    Luminescence 27:249-55. 2012
  6. doi Preparation of antibodies and development of an enzyme-linked immunosorbent assay (ELISA) for the determination of doxycycline antibiotic in milk samples
    Javier Adrian
    Applied Molecular Receptors Group, Department of Chemical and Biomolecular Nanotechnology, Institute for Advanced Chemistry of Catalonia, Spanish Council for Scientific Research, Jordi Girona 18 26, Barcelona, Spain
    J Agric Food Chem 60:3837-46. 2012
  7. doi High-performance liquid chromatography using pressurized liquid extraction for the determination of seven tetracyclines in egg, fish and shrimp
    Yu Liu
    Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, No 68 South Xuefu Road, Changqing Garden, Wuhan, Hubei 430023, PR China
    J Chromatogr B Analyt Technol Biomed Life Sci 917:11-7. 2013
  8. ncbi Detection of tetracycline resistance genes by PCR methods
    Rustam I Aminov
    Rowett Research Institute, Aberdeen, UK
    Methods Mol Biol 268:3-13. 2004
  9. doi Production of monoclonal antibody against doxycycline for immunoassay of seven tetracyclines in bovine muscle and milk
    Feng Gao
    College of Veterinary Medicine, Agricultural University of Hebei, Baoding Hebei, China
    J Environ Sci Health B 48:92-100. 2013
  10. ncbi Liquid chromatography with ultraviolet absorbance detection for the analysis of tetracycline residues in honey
    Pilar Viñas
    Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, E 30071 Murcia, Spain
    J Chromatogr A 1022:125-9. 2004

Scientific Experts

  • Funian Zhao
  • Deng Gaowa Ao
  • Xian Xiang Sun
  • R Injac
  • David W Leung
  • M C Mahedero
  • Skuli Skulason
  • Mark L Nelson
  • L Monser
  • Chong-qiu Jiang
  • Ying Liu
  • Susan Henry
  • Aleksandra Kładna
  • Victoria F Samanidou
  • M M De Zan
  • Ying Xi
  • Chengyu Dong
  • Feng Gao
  • Evaggelia N Evaggelopoulou
  • Javier Adrian
  • Paweł Berczyński
  • Irena Kruk
  • Hassan Y Aboul-Enein
  • Teresa Michalska
  • J Kurittu
  • Michael W Epperly
  • Andrea Nastri Grasso
  • Elisa Cristofani
  • M A Bimazubute
  • Jiantao Li
  • M D Gil Garcia
  • A Carrasco-Pancorbo
  • M J Culzoni
  • H C Goicoechea
  • Silvia Casado-Terrones
  • Nuria Pastor-Navarro
  • S Rempe
  • Kenneth N Agwuh
  • Thao Do Thi
  • Gao Wa Aodeng
  • Abid Iftikhar
  • J Fiori
  • Guo Hui Wan
  • Na Zhang
  • Rustam I Aminov
  • Pilar Viñas
  • Iu M Maksimovskiĭ
  • Steven C Chen
  • Kevin Tan
  • Ying Wei
  • Alexis N Brumwell
  • Harold A Chapman
  • Thomas J Kim
  • Yong Hyun Kim
  • Hui C Zhang
  • Guo X Zhao
  • Jian P Wang
  • Ping Wang
  • Ningning Lu
  • S Y Rawal
  • Fátima Fernández
  • M Pilar Marco
  • E C Gil
  • Francisco Sanchez-Baeza
  • Jean Claude Rwigema
  • M Karp
  • Donna Shields
  • Joel S Greenberger
  • S Lönnberg
  • M Virta
  • Darcy Franicola
  • Peter Wipf
  • M Tod
  • George Georges
  • Brandon Stone
  • Xichen Zhang
  • William McBride
  • Roberta Galarini
  • Laura Fioroni
  • J Crommen
  • Chiara Antonini
  • E Arancio
  • Nilson Dias Vieira
  • P Gustin
  • Luciane dos Santos Teixeira
  • Lilia Coronato Courrol
  • Gloria Tovo
  • P Chiap
  • Arianna Piersanti
  • J Cl Van Heugen

Detail Information

Publications56

  1. ncbi Development and validation of an HPLC confirmatory method for the determination of seven tetracycline antibiotics residues in milk according to the European Union Decision 2002/657/EC
    Victoria F Samanidou
    Laboratory of Analytical Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece
    J Sep Sci 30:2430-9. 2007
    ..for the determination of seven tetracyclines (TCs) in milk: minocycline (MNC), TC, oxytetracycline (OTC), methacycline (MTC), demeclocycline (DMC), chlortetracycline (CTC), and doxycycline (DC)...
  2. doi Inhibition of Epithelial-to-Mesenchymal Transition and Pulmonary Fibrosis by Methacycline
    Ying Xi
    1 Pulmonary and Critical Care Division and Department of Medicine, and
    Am J Respir Cell Mol Biol 50:51-60. 2014
    ..Compounds that directly blocked Smad2/3 phosphorylation were excluded. From 2,100 bioactive compounds, methacycline was identified as an inhibitor of A549 EMT with the half maximal inhibitory concentration (IC50) of roughly 5 μ..
  3. doi Binding of methacycline to human serum albumin at subdomain IIA using multispectroscopic and molecular modeling methods
    Chengyu Dong
    Collecge of Life and Environmental Science, Minzu University of China, Beijing, 100081, China
    Luminescence 28:933-41. 2013
    ..4% in HSA secondary structure. Moreover, the coexistence of metal ions such as Ca(2+) , Al(3+) , Fe(3+) , Zn(2+) , Cu(2+) , Cr(3+) and Cd(2+) can decrease the binding constants of METC-HSA. Copyright © 2012 John Wiley & Sons, Ltd. ..
  4. ncbi Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines
    Kenneth N Agwuh
    Department of Medical Microbiology, Old Medical School, Leeds General Infirmary Great George Street, Leeds LS1 2EX, UK
    J Antimicrob Chemother 58:256-65. 2006
    ..the oldest group, represented by tetracycline, oxytetracycline, chlortetracycline, demeclocycline, lymecycline, methacycline and rolitetracycline is characterized by poor absorption after food...
  5. doi Evaluation of the antioxidant activity of tetracycline antibiotics in vitro
    Aleksandra Kładna
    Department of Medical History and Ethics, Pomeranian Medical Academy, Ul Rybacka 1, 70 204, Szczecin, Poland
    Luminescence 27:249-55. 2012
    ..activity of the seven tetracyclines (TCs; tetracycline, chlortetracycline, oxytetracycline, doxocycline, methacycline, demeclocycline, minocycline) was determined using the free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH(•)) ..
  6. doi Preparation of antibodies and development of an enzyme-linked immunosorbent assay (ELISA) for the determination of doxycycline antibiotic in milk samples
    Javier Adrian
    Applied Molecular Receptors Group, Department of Chemical and Biomolecular Nanotechnology, Institute for Advanced Chemistry of Catalonia, Spanish Council for Scientific Research, Jordi Girona 18 26, Barcelona, Spain
    J Agric Food Chem 60:3837-46. 2012
    ..The assay is very selective for DC with a minor recognition of methacycline (32% of cross-reactivity)...
  7. doi High-performance liquid chromatography using pressurized liquid extraction for the determination of seven tetracyclines in egg, fish and shrimp
    Yu Liu
    Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, No 68 South Xuefu Road, Changqing Garden, Wuhan, Hubei 430023, PR China
    J Chromatogr B Analyt Technol Biomed Life Sci 917:11-7. 2013
    ..and applied to the quantitative determination of oxytetracycline, tetracycline, chlortetracycline, minocycline, methacycline, demeclocycline and doxycycline in egg, fish and shrimp...
  8. ncbi Detection of tetracycline resistance genes by PCR methods
    Rustam I Aminov
    Rowett Research Institute, Aberdeen, UK
    Methods Mol Biol 268:3-13. 2004
    ..of broad-spectrum antibiotics that include tetracycline, chlortetracycline, oxytetracycline, demeclocycline, methacycline, doxycycline, minocycline, and a number of other semisynthetic derivatives...
  9. doi Production of monoclonal antibody against doxycycline for immunoassay of seven tetracyclines in bovine muscle and milk
    Feng Gao
    College of Veterinary Medicine, Agricultural University of Hebei, Baoding Hebei, China
    J Environ Sci Health B 48:92-100. 2013
    ..seven tetracycline drugs (doxycycline, tetracycline, chlortetracycline, oxytetracycline, minocycline, methacycline, demeclocycline)...
  10. ncbi Liquid chromatography with ultraviolet absorbance detection for the analysis of tetracycline residues in honey
    Pilar Viñas
    Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, E 30071 Murcia, Spain
    J Chromatogr A 1022:125-9. 2004
    ..tetracycline, oxytetracycline (OTC), chlortetracycline (CTC), doxycycline (DC), minocycline (MINO) and methacycline (MTC)) in honey of different types...
  11. doi Confirmatory development and validation of HPLC-DADmethod for the determination of tetracyclines in gilthead seabream (Sparus aurata) muscle tissue
    Evaggelia N Evaggelopoulou
    Laboratory of Analytical Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece
    J Sep Sci 35:1372-8. 2012
    ..oxytetracycline, 4-epi-oxytetracycline, chlortetracycline, 4-epi-chlortetracycline, doxycycline, methacycline and demeclocycline were separated on a Kromasil, C18 (250 mm × 4 mm, 5 μm) analytical column by gradient ..
  12. ncbi HPLC-DAD and LC-ESI-MS analysis of doxycycline and related impurities in doxipan mix, a medicated premix for incorporation in medicated feedstuff
    J Fiori
    Dipartimento di Scienze Farmaceutiche, Alma Mater Studiorum Universita di Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    J Pharm Biomed Anal 37:979-85. 2005
    ..A method based on Luna C18 column and UV detection at 346 nm was validated for the determination of DOX in a medicated premix for incorporation in medicated feedstuff...
  13. ncbi Solving matrix-effects exploiting the second order advantage in the resolution and determination of eight tetracycline antibiotics in effluent wastewater by modelling liquid chromatography data with multivariate curve resolution-alternating least squares
    M M De Zan
    Laboratorio de Desarrollo Analítico y Quimiometría, Cátedra de Química Analítica I, Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral, C C 242, S3000ZAA Santa Fe, Argentina
    J Chromatogr A 1179:106-14. 2008
    ..First, eight tetracyclines (tetracycline, oxytetracycline, chlorotetracycline, demeclocycline, methacycline, doxycycline, meclocycline and minocycline) were isolated from 250 mL effluent wastewater samples by solid-..
  14. ncbi Solving matrix effects exploiting the second-order advantage in the resolution and determination of eight tetracycline antibiotics in effluent wastewater by modelling liquid chromatography data with multivariate curve resolution-alternating least squares
    M D Gil Garcia
    Departamento de Hidrogeologia y Quimica Analitica, Facultad de Ciencias Experimentales, Universidad de Almeria, La Canada de San Urbano, 04120 Almeria, Spain
    J Chromatogr A 1179:115-24. 2008
    ..The results showed that the eight tetracycline antibiotics can be successfully determined in wastewaters, the drawbacks due to matrix interferences being adequately handled and overcome by using U-PSL/RBL...
  15. ncbi Thermostability testing and degradation profiles of doxycycline in bulk, tablets, and capsules by HPLC
    Rade Injac
    Faculty of Pharmacy, Department of Pharmaceutical Biology, University of Ljubljana, Askerceva 7, 1000 Ljubljana, Slovenia
    J Chromatogr Sci 45:623-8. 2007
    ..After 90 days, metacycline and 6-epidoxycyline are almost equal in test samples from standard bulk form, tablets, and capsules. It is 27.8+/-0.3%, 13.7+/-0.1%, and 18.8+/-0.2%, respectively...
  16. ncbi Determination of tetracycline residues in honey by CZE with ultraviolet absorbance detection
    Silvia Casado-Terrones
    Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Granada, Spain
    Electrophoresis 28:2882-7. 2007
    ..a sensitive CE method to determine eight tetracyclines (TCs) (chlortetracycline, demeclocycline, doxycycline, methacycline, minocycline, oxytetracycline, TC, and rolitetracycline (RTC)) in honey samples...
  17. ncbi Synthesis of haptens and development of a sensitive immunoassay for tetracycline residues. Application to honey samples
    Nuria Pastor-Navarro
    Departamento de Quimica, Universidad Politecnica de Valencia, Camino de Vera s n, 46071 Valencia, Spain
    Anal Chim Acta 594:211-8. 2007
    ..The optimized ELISA showed cross-reactivity to rolitetracycline (91%), oxytetracycline (30%), methacycline (14%), and chlortetracycline (10%)...
  18. ncbi Quantitative analysis of methacycline hydrochloride by direct potentiometry using the internal solid contact sensor
    Xian Xiang Sun
    Department of Chemical Engineering, Jiangsu Polytechnic University, Changzhou, PR China
    Anal Sci 23:231-3. 2007
    An internal solid contact sensor (ISCS) for the determination of methacycline hydrochloride (MC...
  19. doi Optical properties of metacycline, oxytetracycline and chlortetracycline europium complexes in the presence of hydrogen peroxide
    Andrea Nastri Grasso
    Centro de Lasers e Aplicacoes, IPEN CNEN SP, Av Lineu Prestes 2242 Cidade Universitária, Sao Paulo, SP, Brazil
    J Fluoresc 19:715-21. 2009
    ..The results show that the emission band of EuOTc have enhancement in the presence of hydrogen peroxide. A calibration curve was shown for this complex with the best molar ratio obtained...
  20. ncbi Tetracyclines and pulmonary inflammation
    S Rempe
    Carl T Hayden VA Medical Center, Research RS 151, Building 27, 650 East Indian School Road, Phoenix, AZ 85012, USA
    Endocr Metab Immune Disord Drug Targets 7:232-6. 2007
    Tetracycline and its derivatives, such as chlortetracycline, oxytetracycline, minocycline, doxycycline, methacycline and lymecycline, are naturally occurring or semi-synthetic polyketide compounds that exhibit a well known broad-spectrum ..
  21. doi Characterization of the superoxide anion radical scavenging activity by tetracycline antibiotics in aprotic media
    Aleksandra Kładna
    Department of Medical History and Ethics, Pomeranian Medical University of Szczecin, Ul Rybacka 1, 70 204, Szczecin, Poland
    Luminescence 26:611-5. 2011
    ..radical (O2•¯) scavenging activities of tetracycline, chlortetracycline, oxytetracycline, doxycycline and methacycline were characterized, along with a very efficient O2•¯ scavenger, tiron, in dimethyl sulphoxide (DMSO), using ..
  22. ncbi [Determination of antibiotics residues in the raw fresh milk of farms in the Miyun County of Beijing with Mg2+ -sensitized metacycline fluorescence microscopic imaging technique]
    Ying Liu
    College of Life and Environmental Science, Minzu University of China, Beijing 100081, China
    Guang Pu Xue Yu Guang Pu Fen Xi 30:1279-84. 2010
    ..2 x 10(-6) mol x L(-1)) when 0.50 microL droplet was spotted. This method has been satisfactorily applied to the determination of metacycline in the raw fresh milk samples with the recovery of 93.8%-108% and RSD less than 4.3%...
  23. pmc Screening of antimicrobial agents for in vitro radiation protection and mitigation capacity, including those used in supportive care regimens for bone marrow transplant recipients
    Michael W Epperly
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    In Vivo 24:9-19. 2010
    ..cilastatin, amikacin, ceftazidine, vancomycin, tetracycline, doxycycline, ciprofloxacin, metronidazole, methacycline, minocycline, meclocycline, oxytetracycline and rolitetracycline were added in 1, 10, or 100 micromolar ..
  24. doi Determination of tetracyclines in food samples by molecularly imprinted monolithic column coupling with high performance liquid chromatography
    Xiangli Sun
    Department of Chemistry, Nankai University, Tianjin 300071, PR China
    Talanta 79:926-34. 2009
    ..A method for determination of TCs at low concentration level in milk and honey samples was successfully developed by using the monolithic column as the precolumn for solid phase extraction of six TCs compounds...
  25. doi A confirmatory method for the determination of tetracyclines in muscle using high-performance liquid chromatography with diode-array detection
    Elisa Cristofani
    Istituto Zooprofilattico Sperimentale dell Umbria e delle Marche, Via G Salvemini, 1, I 06126 Perugia, Italy
    Anal Chim Acta 637:40-6. 2009
    ..25, 0.5, 1 and 1.5 times the maximum residue limit) were analysed. Method trueness and precision (repeatability and intra-laboratory reproducibility) as well as decision limits (CCalpha) and detection capabilities (CCbeta) are reported...
  26. ncbi [Studies and application of fluorescence of metacycline enhanced by synergetic effect of beta-cyclodextrin and DBS]
    Deng Gaowa Ao
    College of Chemistry and Chemical Engineering, Inner Mongolia University, Huhhot 010021, China
    Guang Pu Xue Yu Guang Pu Fen Xi 28:2640-3. 2008
    ..996 6. The detection limit was 7.4 x 10(-9) mol x L(-1) this method was satisfactorily applied to the determination of metacycline in pharmaceutical preparations. The recovery was within the range of 95% to 106%...
  27. doi Pre-study and in-study validation of an ultra-high pressure LC method coupled to tandem mass spectrometry for off-line determination of oxytetracycline in nasal secretions of healthy pigs
    M A Bimazubute
    Unit of Pharmacology, Pharmacotherapy and Toxicology, Department for Functional Sciences, Veterinary Medicine, B41, University of Liege, B 4000 Liege, Belgium
    J Chromatogr B Analyt Technol Biomed Life Sci 877:2349-57. 2009
    ..The maximum risk of observing future measurements falling outside the acceptance limits during routine as well as the measurements uncertainty were also estimated...
  28. doi Determination of tetracyclines residues in honey by on-line solid-phase extraction high-performance liquid chromatography
    Jiantao Li
    College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, PR China
    Talanta 75:1245-52. 2008
    ..The relative standard deviations (R.S.D.) for the determination of TCs ranged from 3.4 to 7.1% within a day and ranged from 3.2 to 8.9% in 3 days, respectively...
  29. doi Reversed-phase high-performance liquid chromatography coupled to ultraviolet and electrospray time-of-flight mass spectrometry on-line detection for the separation of eight tetracyclines in honey samples
    A Carrasco-Pancorbo
    Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Fuentenueva s n, E 18071 Granada, Spain
    J Chromatogr A 1195:107-16. 2008
    Eight antibiotics, chlortetracycline, demeclocycline, doxycycline, methacycline, minocycline, oxytetracycline, tetracycline and rolitetracycline, were separated and quantified in Spanish honey extracts of different floral origin using a ..
  30. ncbi Minocycline protects photoreceptors from light and oxidative stress in primary bovine retinal cell culture
    David W Leung
    Acucela, Inc, Bothell, Washington 98021, USA
    Invest Ophthalmol Vis Sci 48:412-21. 2007
    ....
  31. ncbi [Determination of metacycline in mixture sample by synchronous-derivative fluorimetry]
    Gao Wa Aodeng
    College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China
    Guang Pu Xue Yu Guang Pu Fen Xi 26:1530-2. 2006
    ..MTC can be determined in the presence of OTC in the range of OTC+MTC ratio of 1+116-1+1. The recoveries of MTC in the mixture sample are in the range of 94%-102%...
  32. ncbi Rapid liquid chromatographic method for simultaneous determination of tetracyclines antibiotics and 6-epi-doxycycline in pharmaceutical products using porous graphitic carbon column
    L Monser
    Institut National des Sciences Appliquées et de la Technoloqie, Centre Urbain Nord, Tunis, Tunisia
    J Pharm Biomed Anal 23:353-62. 2000
    ..Comparison between retentions obtained with PGC and with silica-based stationary phase (ODS), showed similar variations of the capacity factors with the mobile phase composition, but with a different elution order...
  33. ncbi Qualitative detection of tetracycline residues in milk with a luminescence-based microbial method: the effect of milk composition and assay performance in relation to an immunoassay and a microbial inhibition assay
    J Kurittu
    Department of Biotechnology, University of Turku, Finland
    J Food Prot 63:953-7. 2000
    ..to all tetracyclines tested (oxytetracycline, tetracycline, chlortetracycline, doxycycline, demeclocycline, methacycline, minocycline) than Delvotest SP, and for five tetracyclines out of seven more sensitive than Snap...
  34. ncbi Toxicity in a double-blind, placebo-controlled pilot trial with D-penicillamine and metacycline in secondary progressive multiple sclerosis
    B Dubois
    Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Belgium
    Mult Scler 4:74-8. 1998
    ....
  35. ncbi Evaluation of amperometric detection for the liquid-chromatographic determination of tetracycline antibiotics and their common contaminants in pharmaceutical formulations
    A G Kazemifard
    College of Pharmacy, University of Tehran, Iran
    J Pharm Biomed Anal 16:689-96. 1997
    ..permits the simultaneous determination of trace amounts of chlortetracycline, demeclocycline, doxycycline, methacycline, minocycline, oxytetracycline and tetracycline as well as the separation of their common impurities (epi, ..
  36. ncbi Implementation of OSPOP, an algorithm for the estimation of optimal sampling times in pharmacokinetics by the ED, EID and API criteria
    M Tod
    Departement de Pharmacotoxicologie, Hopital Avicenne, Bobigny, France
    Comput Methods Programs Biomed 50:13-22. 1996
    ..Six to seven distinct sampling times could be estimated. Higher numbers of samples revealed coalescing of design points...
  37. ncbi Simple continuous and simultaneous determination of tetracycline residues
    C E Tsai
    Department of Veterinary Public Health, Faculty of Agriculture, Miyazaki University, Japan
    Res Vet Sci 56:277-83. 1994
    ..for the determination of five different tetracyclines (oxytetracycline, tetracycline, chlortetracycline, methacycline and doxycycline)...
  38. ncbi Application of optimal sampling theory to the determination of metacycline pharmacokinetic parameters: effect of model misspecification
    M Tod
    Departement de Pharmacotoxicologie, Hopital Avicenne, Bobigny, France
    J Pharmacokinet Biopharm 22:129-46. 1994
    ..In this context, the stochastic model was superior and yielded very good estimates of the bioavailability parameters with only 8 samples per subject...
  39. ncbi [Antibiotic binding by leukocytes from brucellosis patients]
    A Z Nigmatulin
    Karaganda Medical Institute
    Antibiot Khimioter 35:40-2. 1990
    ..aggravation at the intoxication peak and accumulation of a large number of Brucella in the cells binding of methacycline, rifampicin and gentamicin somewhat increased...
  40. ncbi Assay and purity control of metacycline by thin-layer chromatography combined with UV and fluorescence densitometry--a comparison with liquid chromatography
    W Naidong
    Katholieke Universiteit Leuven, Laboratorium voor Farmaceutische Chemie, Leuven, Belgium
    J Pharm Biomed Anal 9:717-23. 1991
    ..9999. For TLC-UV the relative standard deviation (RSD) for the assay of the main component was less than 2%, for TLC-F less than 3.0% and for LC less than 1.0%...
  41. ncbi Determination of metacycline and related substances by column liquid chromatography on poly(styrene-divinylbenzene)
    W Naidong
    Katholieke Universiteit Leuven, Institut voor Farmaceutische Wetenschappen, Belgium
    J Chromatogr 586:61-6. 1991
    ..2-Acetyl-2 decarboxamidometacycline, 6-epidoxycycline and doxycycline were the main impurities, while 4-epimetacycline and oxytetracycline were minor impurities...
  42. ncbi Isolation of doxycycline, 6-epidoxycycline and 2-acetyl-2- decarboxamidometacycline from commercial metacycline by preparative column liquid chromatography on silica gel
    W Naidong
    Katholieke Universiteit Leuven, Institut voor Farmaceutische Wetenschappen, Belgium
    J Chromatogr 586:67-72. 1991
    ..The presence of the 2-acetyl derivative was not surprising since analogous 2-acetyl derivatives have been identified in other tetracyclines...
  43. ncbi A group-specific microbiological test for the detection of tetracycline residues in raw milk
    J Kurittu
    Department of Biotechnology, University of Turku, Finland
    J Agric Food Chem 48:3372-7. 2000
    ..The detection limits for tetracycline, oxytetracycline, chlortetracycline, doxycycline, methacycline, demeclocycline, and minocycline were between 2 and 35 ng/mL...
  44. ncbi Analysis of metacycline by capillary electrophoresis
    E C Gil
    Centro de Química Farmacéutica, Atabey, Playa, Havana, Cuba
    Electrophoresis 22:497-502. 2001
    ..The limits of detection and quantitation are 0.024% and 0.06%, respectively, relative to a 2.5 mg/mL solution. Six commercial samples were analyzed quantitatively...
  45. ncbi Determination of tetracyclines in ovine milk by high-performance liquid chromatography with a coulometric electrode array system
    Funian Zhao
    Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
    J Chromatogr A 1055:109-14. 2004
    ..to analyze residual tetracyclines (TCs) (oxytetracycline (OTC), tetracycline (TC), chlortetracycline (CTC), methacycline (MTC), doxycycline (DC)) in ovine milk, using high-performance liquid chromatography (HPLC) with a coulometric ..
  46. ncbi Precision study on capillary electrophoresis methods for metacycline
    Thao Do Thi
    Laboratory of Pharmaceutical Chemistry and Drug Analysis, Faculty of Pharmaceutical Sciences, Katholieke Universiteit Leuven, Leuven, Belgium
    Electrophoresis 27:2317-29. 2006
    ..Although the new method could be transferred to different instruments, the precision remained poor mainly due to the contributions of the between-replicate and the between-injection variances...
  47. ncbi In vitro release of tetracyclines in presence of H2-receptor antagonists
    Abid Iftikhar
    Faculty of Pharmacy, Hamdard University, Karachi
    Pak J Pharm Sci 18:55-60. 2005
    ..e., tetracycline, demeclocycline, oxytetracycline, methacycline and doxycycline in presence of cimetidine and ranitidine has been studied by USP XX dissolution method...
  48. ncbi Determination of tetracyclines residues in honey using high-performance liquid chromatography with potassium permanganate-sodium sulfite-beta-cyclodextrin chemiluminescence detection
    Guo Hui Wan
    Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, PR China
    J Chromatogr B Analyt Technol Biomed Life Sci 824:57-64. 2005
    ..4% within a day (n=11) and ranged from 2.2 to 8.6% in 3 days (n=9), respectively. The method was successfully applied to the determination of TCA residues in honey samples. The possible mechanism of the CL reaction was also discussed...
  49. ncbi Lysozyme-enhanced europium(III)-metacycline luminescence and its application to the determination of metacycline
    Na Zhang
    Department of Chemistry, Shandong Normal University, Jinan, 250014, China
    Anal Sci 21:541-4. 2005
    ..Interferences of other coexisting substances were studied. The developed method was successfully applied to the determination of MC in serum and urine samples. The mechanism of fluorescence enhancement was also studied...
  50. ncbi Improvements in europium sensitized fluorimetric determination of demeclocycline and methacycline
    M C Mahedero
    Department of Analytical Chemistry, University of Extremadura, 06071 Badajoz, Spain
    J Pharm Biomed Anal 37:1101-4. 2005
    Demeclocycline (DM) and methacycline (MT) have been determined by europium-sensitized fluorescence, using EDTA as co-ligand and cetyltrimethylammonium chloride as surfactant...
  51. ncbi Study of the interactions between tetracycline analogues and lysozyme
    Chong Qiu Jiang
    Department of Chemistry, Shandong Normal University, Jinan 250014, China
    Bioorg Med Chem 12:2043-7. 2004
    The interactions between tetracycline analogues (oxytetracycline, doxycycline, methacycline) and lysozyme (LYSO) were studied by using UV-visible absorption and spectrofluorimetric method...
  52. ncbi Development of a simple HPLC method for separation of doxycycline and its degradation products
    S Skulason
    Faculty of Pharmacy, University of Iceland, Hagi, Hofsvallagotu 53, IS 107 Reykjavik, Iceland
    J Pharm Biomed Anal 33:667-72. 2003
    ..Preliminary results indicate that this method can also be applied for separating other tetracyclines such as minocycline, chlortetracycline, tetracycline and demeclocycline...
  53. ncbi [Efficacy of treatment of chronic destructive forms of apical periodontitis using oral decontamination antibiotic therapy]
    Iu M Maksimovskiĭ
    Stomatologiia (Mosk) 82:16-9. 2003
    ..05 and p < 0.01) after preventive treatment with lincomycin or rondomycin, characterized by potent osteotropic effects (decontamination with rondomycin 81.8%, with lincomycin 70.3% vs. 31.0% without decontamination therapy)...
  54. ncbi Versatile and facile synthesis of diverse semisynthetic tetracycline derivatives via Pd-catalyzed reactions
    Mark L Nelson
    Paratek Pharmaceuticals, Inc, 75 Kneeland Street, Boston, Massachusetts 02111, USA
    J Org Chem 68:5838-51. 2003
    ..these reactions, including numerous upper periphery derivatives of doxycycline, minocycline, sancycline, and methacycline modified at positions C7, C9, and C6-C13 on the tetracycline naphthacene ring...
  55. ncbi Non-antimicrobial properties of tetracyclines--dental and medical implications
    S Y Rawal
    School of Dentistry, University of the West Indies, Eric Williams Medical Sciences Complex, Mount Hope, Uriah Butler Highway, Champs Fleur, Trinidad and Tobago
    West Indian Med J 50:105-8. 2001
    ..b>Methacycline, doxycycline and minocycline are all semi-synthetic derivatives...
  56. ncbi The extra-weak chemiluminescence generated during oxidation of some tetracycline antibiotics. 1. Autoxidation
    I Kruk
    Institute of Physics, Technical University of Szczecin, Poland
    J Photochem Photobiol B 14:329-43. 1992
    ..The data support the concept that, during the autoxidation of TCs, cytotoxic oxygen species such as HO., O2.-, H2O2 and 1O2 are formed...