maprotiline

Summary

Summary: A bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use.

Top Publications

  1. doi The antidepressants maprotiline and fluoxetine have potent selective antiproliferative effects against Burkitt lymphoma independently of the norepinephrine and serotonin transporters
    Suzanne M Cloonan
    School of Biochemistry and Immunology, Trinity College Dublin, Ireland
    Leuk Lymphoma 51:523-39. 2010
  2. doi The antidepressants maprotiline and fluoxetine induce Type II autophagic cell death in drug-resistant Burkitt's lymphoma
    Suzanne M Cloonan
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Int J Cancer 128:1712-23. 2011
  3. doi The synergistic interaction between morphine and maprotiline after intrathecal injection in rats
    Vera L A Pettersen
    Programa de Pós Graduação em Cirurgia Geral da Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Anesth Analg 109:1312-7. 2009
  4. ncbi [Comparative observation on efficacy of jieyu pill and maprotiline in treating depression]
    Zhen ming Shen
    5th Hospital of Tangshan City, Hebei Province 063004
    Zhongguo Zhong Xi Yi Jie He Za Zhi 24:415-7. 2004
  5. ncbi Central and peripheral anti-inflammatory effects of maprotiline on carrageenan-induced paw edema in rats
    V Hajhashemi
    Department of Pharmacology, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
    Inflamm Res 59:1053-9. 2010
  6. pmc The involvement of the opioidergic system in the antinociceptive mechanism of action of antidepressant compounds
    A M Gray
    Division of Pharmacology, The Welsh School of Pharmacy, UWC, Cardiff, Wales
    Br J Pharmacol 124:669-74. 1998
  7. ncbi Imipramine, mianserine and maprotiline block delayed rectifier potassium current in ventricular myocytes
    Oscar Casis
    Department of Physiology, School of Pharmacy, University of the Basque Country, Bilbao, Spain
    Pharmacol Res 45:141-6. 2002
  8. ncbi Effect of the antidepressant maprotiline on Ca2+ movement and proliferation in human prostate cancer cells
    Shu Shong Hsu
    Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
    Clin Exp Pharmacol Physiol 31:444-9. 2004
  9. ncbi Gender differences in the efficacy of fluoxetine and maprotiline in depressed patients: a double-blind trial of antidepressants with serotonergic or norepinephrinergic reuptake inhibition profile
    F Martenyi
    Eli Lilly Regional Medical Center, Barichgasse 40 42, A 1030, Vienna, Austria
    Eur Neuropsychopharmacol 11:227-32. 2001
  10. ncbi Comparisons of glucose-insulin homeostasis following maprotiline and fluoxetine treatment in depressed males
    Yi Chyan Chen
    Department of Psychiatry, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    J Affect Disord 103:257-61. 2007

Detail Information

Publications152 found, 100 shown here

  1. doi The antidepressants maprotiline and fluoxetine have potent selective antiproliferative effects against Burkitt lymphoma independently of the norepinephrine and serotonin transporters
    Suzanne M Cloonan
    School of Biochemistry and Immunology, Trinity College Dublin, Ireland
    Leuk Lymphoma 51:523-39. 2010
    ..We report that the SSRI fluoxetine and the NSRI maprotiline are potent antiproliferative agents against human Burkitt lymphoma (BL), having little effect on normal blood ..
  2. doi The antidepressants maprotiline and fluoxetine induce Type II autophagic cell death in drug-resistant Burkitt's lymphoma
    Suzanne M Cloonan
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Int J Cancer 128:1712-23. 2011
    ..We report that the antidepressants maprotiline and fluoxetine induce autophagic PCD in the chemoresistant Burkitt's lymphoma (BL) cell line DG-75, which does ..
  3. doi The synergistic interaction between morphine and maprotiline after intrathecal injection in rats
    Vera L A Pettersen
    Programa de Pós Graduação em Cirurgia Geral da Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Anesth Analg 109:1312-7. 2009
    ..effects of the intrathecal administration of morphine with that of a nonselective (amitriptyline) or selective (maprotiline or citalopram) antidepressant drug using the thermal withdrawal test in rats...
  4. ncbi [Comparative observation on efficacy of jieyu pill and maprotiline in treating depression]
    Zhen ming Shen
    5th Hospital of Tangshan City, Hebei Province 063004
    Zhongguo Zhong Xi Yi Jie He Za Zhi 24:415-7. 2004
    ..To investigate the clinical efficacy, adverse reaction and safety of Jieyu pill (JYP) in treating depression...
  5. ncbi Central and peripheral anti-inflammatory effects of maprotiline on carrageenan-induced paw edema in rats
    V Hajhashemi
    Department of Pharmacology, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
    Inflamm Res 59:1053-9. 2010
    To explore the site of action of maprotiline, as an atypical antidepressant, on carrageenan-induced paw edema.
  6. pmc The involvement of the opioidergic system in the antinociceptive mechanism of action of antidepressant compounds
    A M Gray
    Division of Pharmacology, The Welsh School of Pharmacy, UWC, Cardiff, Wales
    Br J Pharmacol 124:669-74. 1998
    ....
  7. ncbi Imipramine, mianserine and maprotiline block delayed rectifier potassium current in ventricular myocytes
    Oscar Casis
    Department of Physiology, School of Pharmacy, University of the Basque Country, Bilbao, Spain
    Pharmacol Res 45:141-6. 2002
    Imipramine, mianserine and maprotiline are three widely used antidepressant drugs with different chemical structure...
  8. ncbi Effect of the antidepressant maprotiline on Ca2+ movement and proliferation in human prostate cancer cells
    Shu Shong Hsu
    Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
    Clin Exp Pharmacol Physiol 31:444-9. 2004
    1. The effect of maprotiline, an antidepressant, on human prostate cells is unclear...
  9. ncbi Gender differences in the efficacy of fluoxetine and maprotiline in depressed patients: a double-blind trial of antidepressants with serotonergic or norepinephrinergic reuptake inhibition profile
    F Martenyi
    Eli Lilly Regional Medical Center, Barichgasse 40 42, A 1030, Vienna, Austria
    Eur Neuropsychopharmacol 11:227-32. 2001
    ..The pharmacodynamic effect of antidepressants may also show gender differences, as suggested by reports of better response of young women to non-tricyclic antidepressants...
  10. ncbi Comparisons of glucose-insulin homeostasis following maprotiline and fluoxetine treatment in depressed males
    Yi Chyan Chen
    Department of Psychiatry, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    J Affect Disord 103:257-61. 2007
    ..To investigate the effects of antidepressants on glucose-insulin homeostasis, we provided homogenous situation and performed standard procedures to assess the interactions of antidepressants and glucose regulation during hospitalization...
  11. ncbi Neuroleptic malignant-like syndrome due to donepezil and maprotiline
    Norio Ohkoshi
    Department of Neurology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan ohkoshin md tsukuba ac jp
    Neurology 60:1050-1. 2003
  12. ncbi Atypical tetracyclic antidepressant maprotiline is an antagonist at cardiac hERG potassium channels
    Claudia Kiesecker
    Department of Cardiology, Medical University Hospital Heidelberg, Im Neuenheimer Feld 350, 69120, Heidelberg, Germany
    Naunyn Schmiedebergs Arch Pharmacol 373:212-20. 2006
    b>Maprotiline is an antidepressant compound with an atypical tetracyclic structure that is widely used in elderly patients due to its favourable side-effect profile...
  13. ncbi Inhibition of cardiac HERG potassium channels by antidepressant maprotiline
    Tania Ferrer-Villada
    Unidad de Investigación Carlos Méndez del Centro Universitario de Investigaciones Biomédicas de la Universidad de Colima, Apdo Postal 199, C P 28000, Colima, Mexico
    Eur J Pharmacol 531:1-8. 2006
    ..block of human ether-a-go-go-related gene (HERG) K+ channels expressed in cells HEK-293 and Xenopus oocytes by maprotiline. The IC50 determined at 0 mV on HERG expressed HEK-293 cell and oocytes was 5.2 and 23.7 microM, respectively...
  14. ncbi Combination of clozapine and maprotiline in refractory psychotic depression
    M Hrdlicka
    Department of Psychiatry, Charles University, Second Medical School, V Uvalu 84, 15006, Prague, Czech Republic
    Eur Psychiatry 17:484. 2002
  15. ncbi Cardiovascular effects of fluvoxamine and maprotiline in depressed patients
    W Hewer
    Neurobiology Unit, Central Institute of Mental Health, Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 246:1-6. 1995
    ..In the present study the cardiovascular effects of fluvoxamine and maprotiline were compared in a double-blind trial in which the quantitative changes in ECGs were assessed before and during ..
  16. ncbi [Antidepressants with different action mechanisms in the treatment of chronic daily headache]
    A V Amelin
    Zh Nevrol Psikhiatr Im S S Korsakova 107:38-44. 2007
    ..inhibitor of serotonin reuptake), milnacipran (selective inhibitor of serotonin and noradrenalin reuptake) and maprotiline (selective inhibitor of noradrenalin reuptake) have been compared during the treatment of 120 patients with ..
  17. ncbi Effects of noradrenaline and serotonin reuptake inhibitors on pituitary-adrenocortical and sympatho-adrenomedullar system of adult rats
    Sladjana Dronjak
    Institute of Nuclear of Sciences Vinca, Laboratory of Molecular Biology and Endocrinology, 11000 Belgrade, Serbia
    Neuro Endocrinol Lett 28:614-20. 2007
    ..activity of pituitary-adrenocortical and sympatho-adrenomedullar systems in animals, we compared the effects of maprotiline (a selective inhibitor of noradrenaline reuptake) and fluxilan (a selective inhibitor of serotonin reuptake) on ..
  18. ncbi [Review of pharmacological efficacies and side effects of antidepressants]
    Atsuko Ikenouchi-Sugita
    Department of Psychiatry, University of Occupational and Environmental Health
    Nihon Rinsho 65:1633-7. 2007
    ..Clinicians should select antidepressants considering their pharmacologic profiles and avoiding adverse effects...
  19. ncbi Maprotiline induced weight gain in depressive disorder: changes in circulating ghrelin and adiponectin levels and insulin sensitivity
    Murat Pinar
    Tatvan Military Hospital, Internal Medicine Service, Tatvan Bitlis, Turkey
    Prog Neuropsychopharmacol Biol Psychiatry 32:135-9. 2008
    ..We investigated the relation of maprotiline induced weight gain to serum ghrelin and adiponectin levels, as well as insulin resistance in lean subjects ..
  20. ncbi Mouse strain differences in the unpredictable chronic mild stress: a four-antidepressant survey
    Ipek Yalcin
    Universite Francois Rabelais de Tours, France
    Behav Brain Res 193:140-3. 2008
    ..drugs including the tricyclics imipramine (20 mg/(kgday)) and desipramine (10 mg/(kgday)), the tetracyclic maprotiline (20 mg/(kgday)) and the selective serotonin reuptake inhibitor (SSRI) fluoxetine (10mg/(kgday)) in both Swiss ..
  21. ncbi [QT prolongation and torsade de pointes tachycardia during therapy with maprotiline. Differential diagnostic and therapeutic aspects]
    S Lentini
    Medizinische Klinik und Poliklinik II,
    Dtsch Med Wochenschr 126:1396-400. 2001
    ..In addition, there had been long-term anti-depressant therapy with the tetracyclic agent maprotiline. INVESTIGATIONS: Torsade de pointes tachycardia was documented in the electrocardiograms...
  22. ncbi Age-dependent interactive changes in serotonergic and noradrenergic cortical axon terminals in F344 rats
    Sadamu Nakai
    Department of Basic Gerontology, National Center for Geriatrics and Gerontology, 36 3 Gengo, Morioka, Obu, Aichi 474 8522, Japan
    Neurosci Res 54:220-9. 2006
    ..We also used noradrenaline uptake inhibitor (maprotiline) to verify the effects of NA on degeneration of 5-HT axons...
  23. ncbi Maprotiline block of the human ether-a-go-go-related gene (HERG) K+ channel
    Su Hyun Jo
    Department of Physiology, Institute of Bioscience and Biotechnology, Kangwon National University College of Medicine, Chuncheon, Korea
    Arch Pharm Res 30:453-60. 2007
    b>Maprotiline, an atypical antidepressant, can induce prolonged QT and torsades de pointes. We studied the effects of maprotiline on human ether-a-go-go-related gene (HERG) channels expressed in Xenopus oocytes and HEK293 cells...
  24. ncbi Are the effects of the antidepressants amitriptyline, maprotiline, and fluoxetine on inhibitory avoidance state-dependent?
    M Carmen Arenas
    Department of Psychobiology, University of Valencia, Blasco Ibanez 21, 46010 Valencia, Spain
    Behav Brain Res 166:150-8. 2006
    ..The present work was designed to investigate whether the antidepressants amitriptyline (30 mg/kg), maprotiline (25 mg/kg), and fluoxetine (15 mg/kg) produce SDL of the inhibitory avoidance conditioning in male and female ..
  25. ncbi Chronic inhibition of the norepinephrine transporter in the brain participates in seizure sensitization to cocaine and local anesthetics
    Shigeaki Arai
    Department of Dental Pharmacology, Division of Integrated Medical Science, Hiroshima University Graduate School of Biomedical Sciences, Kasumi 1 2 3, Minami Ku, Hiroshima 734 8553, Japan
    Brain Res 964:83-90. 2003
    ..Daily treatments of desipramine and maprotiline, selective norepinephrine uptake inhibitors, markedly increased the incidence and intensity of lidocaine-..
  26. ncbi Falling spells associated with antidepressant drug treatment
    R Winter
    Department of Neurology, University Hospital, Heidelberg, Federal Republic of Germany
    Eur Arch Psychiatry Clin Neurosci 241:314-6. 1992
    ..Further factors predisposing to the falling spells remain to be defined...
  27. ncbi Reduction of Submissive Behavior Model for antidepressant drug activity testing: study using a video-tracking system
    Albert Pinhasov
    CNS Research Team, Johnson and Johnson Pharmaceutical Research and Development, L L C Spring House, Pennsylvania 19477 0776, USA
    Behav Pharmacol 16:657-64. 2005
    ..with manual scoring, and to extend those results to studies with other drugs, including the antidepressant maprotiline and the delta-opioid antagonist naltrindole, which is not known to have antidepressant activity...
  28. ncbi Changes in AMPA subunit expression in the mouse brain after chronic treatment with the antidepressant maprotiline: a link between noradrenergic and glutamatergic function?
    Chay Hoon Tan
    Department of Pharmacology, National University of Singapore, 119260, Singapore, Singapore
    Exp Brain Res 170:448-56. 2006
    ..expression of AMPA receptor subunits in different brain regions of mice that had been chronically injected with maprotiline. The latter is a modified tricyclic antidepressant that functions as a noradrenaline uptake inhibitor...
  29. ncbi Synthesis and C-11 labeling of three potent norepinephrine transporter selective ligands ((R)-nisoxetine, lortalamine, and oxaprotiline) for comparative PET studies in baboons
    Kuo Shyan Lin
    Chemistry Department, Brookhaven National Laboratory, Bldg 555, Upton, NY 11973, USA
    Bioorg Med Chem 13:4658-66. 2005
    ..These C-11 labeled tracers allowed us to carry out comparative studies of NET in baboons with positron emission tomography (PET) and evaluate their potential as PET tracers for imaging brain NET...
  30. ncbi [Placebo to antidepressant effects ratio by electroencephalographic data]
    V K Bochkarev
    Zh Nevrol Psikhiatr Im S S Korsakova 104:42-8. 2004
    An analysis of EEG spectral characteristics of placebo effect and antidepressant (fluoxetine, maprotiline) monotherapy in patients with mild or moderate depressive episodes (ICD-10) has been conducted...
  31. ncbi Acute effects of maprotiline on learning, anxiety, activity and analgesia in male and female mice
    Concepcion Vinader-Caerols
    Department of Psychobiology, University of Valencia, Blasco Ibanez 21, 46010 Valencia, Spain
    Acta Neurobiol Exp (Wars) 66:23-31. 2006
    The acute effects of maprotiline (2.5, 5, 10, 15, 20 or 25 mg/kg) on learning, anxiety, activity and analgesia in male and female mice were evaluated...
  32. ncbi Chronic treatment with antidepressants decreases intraoperative core hypothermia
    Akira Kudoh
    Department of Anesthesiology, Hirosaki National Hospital, Japan
    Anesth Analg 97:275-9, table of contents. 2003
    ..of the patients treated with clomipramine tended to be higher than that of the patients treated with maprotiline. In conclusion, intraoperative core hypothermia in chronically depressed patients was decreased...
  33. ncbi Current perception thresholds of patients with long-term administration of maprotiline
    A Kudoh
    Department of Anesthesiology, Hirosaki National Hospital, Hirosaki, Japan
    Pharmacopsychiatry 36:57-60. 2003
    ..evaluate sensory nerve function using current perception thresholds (CPTs) in patients who were administrated maprotiline. Twelve patients with post-herpetic neuralgia and 20 control subjects were studied...
  34. ncbi Differential effects of K(ATP) channel blockers on [(3)H]-noradrenaline overflow after short- and long-term exposure to (+)-oxaprotiline or desipramine
    Klaus Eckhardt
    Sektion Klinische Neuropharmakologie, Neurologische Universitatsklinik Freiburg, Breisacherstrasse 64, 79106, Freiburg, Germany
    Naunyn Schmiedebergs Arch Pharmacol 367:168-75. 2003
    ..The unexpected effect of longer exposure to uptake blockers could be somehow related to the clinical time latency of the antidepressant efficacy of monoamine uptake blockers...
  35. ncbi Comparative evaluation of positron emission tomography radiotracers for imaging the norepinephrine transporter: (S,S) and (R,R) enantiomers of reboxetine analogs ([11C]methylreboxetine, 3-Cl-[11C]methylreboxetine and [18F]fluororeboxetine), (R)-[11C]nisox
    Yu Shin Ding
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurochem 94:337-51. 2005
    ..Thus, to our knowledge (S,S)-[11C]MRB remains by far the most promising NET ligand for PET studies...
  36. ncbi Serotonin syndrome due to association of venlafaxine, maprotiline and reboxetine
    José Manuel Bertolín-Guillén
    Eur Psychiatry 19:456-7. 2004
  37. ncbi Tricyclic antidepressants, QT interval prolongation, and torsade de pointes
    W Victor R Vieweg
    Department of Psychiatry, Cardiology Division, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23238 5414, USA
    Psychosomatics 45:371-7. 2004
    ..Case reports identify amitriptyline and maprotiline as the tricyclic antidepressants most likely to provoke torsade de pointes...
  38. ncbi Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: a multi-level, single-sample approach
    H Kirchherr
    Medical Laboratory Bremen, Haferwende 12, D 28359 Bremen, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 843:100-13. 2006
    ..flupentixol, fluphenazine, fluvoxamine, haloperidol, hydroxyrisperidone, imipramine, levomepromazine, maprotiline, mianserine, mirtazapine, moclobemide, norclomipramine, nordoxepin, norfluoxetine, nortriptyline, O-..
  39. ncbi Involvement of norepinephrine neurons in the hypothermia induced by intracerebroventricular administration of 6-hydroxydopamine in mice, evidenced by antidepressants
    I Leroux-Nicollet
    Unité de Neuropsychopharmacologie Expérimentale, U A 1170 du C N R S, U F R de Médecine et Pharmacie de Rouen, Saint Etienne du Rouvray, France
    J Neural Transm 74:17-27. 1988
    ..hypothermia is partly antagonized by norepinephrine uptake inhibitors (desipramine, nomifensine, viloxazine, maprotiline, protryptiline), as well as amfonelic acid...
  40. ncbi Effects of psychotropic drugs on seizure threshold
    Francesco Pisani
    Department of Neurosciences and of Psychiatric and Anaesthesiological Sciences, First Neurological Clinic, The University of Messina, Messina, Italy
    Drug Saf 25:91-110. 2002
    ..converges on the following: seizures triggered by psychotropic drugs are a dose-dependent adverse effect; maprotiline and clomipramine among antidepressants and chlorpromazine and clozapine among antipsychotics that have a ..
  41. ncbi A comparative solid-phase extraction study for the simultaneous determination of fluoxetine, amitriptyline, nortriptyline, trimipramine, maprotiline, clomipramine, and trazodone in whole blood by capillary gas-liquid chromatography with nitrogen-phosphoru
    M A Martinez
    Department of Chemistry, National Institute of Toxicology, Ministry of Justice, C Luis Cabrera 9, 28002 Madrid, Spain
    J Anal Toxicol 27:353-8. 2003
    ..the simultaneous detection of the seven antidepressants fluoxetine, amitriptyline, nortriptyline, trimipramine, maprotiline, clomipramine, and trazodone in whole blood at concentration levels of 100-2000 ng/mL by gas chromatography ..
  42. ncbi Solid-phase extraction and analysis of 20 antidepressant drugs in human plasma by LC/MS with SSI method
    Tatsuo Shinozuka
    Department of Central Research Laboratory, School of Medicine, Keio University, 35 Shinanomachi, Tokyo 160 8582, Japan
    Forensic Sci Int 162:108-12. 2006
    ..amitriptyline, desipramine, trimipramine, nortriptyline, clomipramine, amoxapine, lofepramine, dosulepin, maprotiline, mianserin, setiptiline, trazodone, fluvoxamine, paroxetine, milnacipran, sulpiride, tandspirone, ..
  43. ncbi SSRIS versus tricyclic antidepressants in depressed inpatients: a meta-analysis of efficacy and tolerability
    I M Anderson
    Department of Psychiatry, University of Manchester, Manchester Royal Infirmary, United Kingdom
    Depress Anxiety 7:11-7. 1998
    ..and amitriptyline) and those with predominantly noradrenaline reuptake (imipramine, desipramine and maprotiline), only the dual action TCAs had greater efficacy than SSRIs (effect size = -0.30, 95% CI -0.54 to -0.05, P = 0...
  44. ncbi Tianeptine: a review of its use in depressive disorders
    A J Wagstaff
    Adis International Limited, Mairangi Bay, Auckland, New Zealand
    CNS Drugs 15:231-59. 2001
    ..Comparison with maprotiline indicated superior efficacy for tianeptine but dothiepin appeared superior in another study...
  45. ncbi Effects of zimeldine and its metabolites, clomipramine, imipramine and maprotiline in experimental allergic neuritis in Lewis rats
    B O Bengtsson
    Department of Psychiatry, Faculty of Health Sciences, University Hospital, Linkoping, Sweden
    J Neuroimmunol 39:109-22. 1992
    ..its metabolites norzimeldine and CPP 200 as well as of the antidepressants clomipramine, imipramine and maprotiline on in vitro immune response were tested...
  46. ncbi The interaction of antidepressant drugs with enteric 5-HT7 receptors
    A Lucchelli
    Department of Experimental and Applied Pharmacology, School of Pharmacy, University of Pavia, Italy
    Naunyn Schmiedebergs Arch Pharmacol 362:284-9. 2000
    In this study the functional interaction of the antidepressant drugs amitriptyline, mianserin, maprotiline, imipramine, fluoxetine and the putative antidepressant drug flibanserin has been studied on 5-HT7-mediated responses to 5-..
  47. ncbi An investigation of monoamine receptors involved in antinociceptive effects of antidepressants
    Fumiko Yokogawa
    Department of Anesthesiology, School of Medicine, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8666, Japan
    Anesth Analg 95:163-8, table of contents. 2002
    ..Antidepressants acting as potent inhibitors of norepinephrine reuptake (nisoxetine, nortriptyline, and maprotiline) or inhibiting reuptake of both norepinephrine and serotonin (5-HT) (imipramine and milnacipran) induced dose-..
  48. ncbi Aldehyde oxidase activity and inhibition in hepatocytes and cytosolic fractions from mouse, rat, monkey and human
    Jasminder Sahi
    CELLZDIRECT, 4301 Emperor Blvd, Durham, North Carolina 27703, USA
    Drug Metab Lett 2:176-83. 2008
    ..e. raloxifene, perphenazine, menadione, maprotiline, ketoconazole, erythromycin, and estradiol...
  49. ncbi Clinical trials with hypericum extracts in patients with depression--results, comparisons, conclusions for therapy with antidepressant drugs
    Volker Schulz
    Phytomedicine 9:468-74. 2002
    ..in water (V/V), of which six were placebo-controlled, two compared Hypericum with imipramine and one each with maprotiline, amitriptyline, sertraline or light therapy. Dosages ranged from 450-1200 mg extract per day...
  50. ncbi Dothiepin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness
    S G Lancaster
    ADIS Drug Information Services, Manchester, England
    Drugs 38:123-47. 1989
    ..In addition, dothiepin appears to be comparable to imipramine, doxepin, maprotiline, mianserin, fluoxetine, fluvoxamine and trazodone...
  51. ncbi Development and preliminary application of high-performance liquid chromatographic assay of urinary metabolites of diazepam in humans
    K Chiba
    Department of Clinical Pharmacology, International Medical Center of Japan, Tokyo
    J Chromatogr B Biomed Appl 668:77-84. 1995
    ..None of 22 drugs and 17 metabolites, except for mianserin, maprotiline and imipramine N-oxide, interfered with the detection of DZP metabolites...
  52. ncbi Effects of selective adrenoceptor agonists and antagonists on aggressive behavior elicited by apomorphine, DL-dopa and fusaric acid in REM-sleep-deprived rats
    L R Troncone
    Servico de Farmacologia, Instituto Butantan, Paulo, Brasil
    Physiol Behav 50:173-8. 1991
    ..with phentolamine, propranolol, metaraminol, prazosin, clonidine, yohimbine, isoproterenol, butoxamine and maprotiline. Only isoproterenol reduced FA-induced aggressiveness...
  53. ncbi Inhibition of the cardiac L-type calcium channel current by antidepressant drugs
    Ivan Zahradnik
    Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Vlarska 5, 833 34 Bratislava, Slovak Republic
    J Pharmacol Exp Ther 324:977-84. 2008
    ..33 Hz, the antidepressants imipramine, clomipramine, desipramine, amitriptyline, maprotiline, citalopram, and dibenzepin blocked I(Ca), with IC(50) values of 8.3, 11.6, 11.7, 23.2, 31.0, 64.5, and 364 muM...
  54. ncbi [Application of liquid chromatography coupled with mass spectrometry (LC/MS) to determine antidepressants in blood samples]
    Ewa Pufal
    Katedry Medycyny Sadowej UMK w Toruniu, Collegium Medicum im Ludwika Rydygiera w Bydgoszczy
    Arch Med Sadowej Kryminol 58:171-6. 2008
    ..twelve antidepressant drugs (amitriptyline, chlorpromazine, clomipramine, doxepin, fluoxetine, levomepromazine, maprotiline, paroxetine, perazine, promazine, sertraline, thioridazine) in blood samples was developed using high-..
  55. ncbi Effect of pharmacologically selective antidepressants on serotonin uptake in rat platelets
    Z Fisar
    Department of Psychiatry, 1st Faculty of Medicine, Charles University, Ke Karlovu 11, 120 00 Prague 2, Czech Republic
    Gen Physiol Biophys 24:113-28. 2005
    ..Laboratory rats were administered norepinephrine reuptake inhibitors (desipramine, maprotiline), selective 5-HT reuptake inhibitor (citalopram), reversible monoamine oxidase inhibitor (moclobemide), and ..
  56. pmc Destruction of dopaminergic neurons in the midbrain by 6-hydroxydopamine decreases hippocampal cell proliferation in rats: reversal by fluoxetine
    Katsuaki Suzuki
    Osaka Hamamatsu Joint Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
    PLoS ONE 5:e9260. 2010
    ..effects of the selective serotonin reuptake inhibitor (SSRI) fluoxetine and the selective noradrenaline reuptake inhibitor maprotiline on the reduction in cell proliferation in the subgranular zone (SGZ) by the unilateral 6-OHDA lesion.
  57. doi Potential utility of histamine H3 receptor antagonist pharmacophore in antipsychotics
    Y von Coburg
    Johann Wolfgang Goethe Universitat, Institut fur Pharmazeutische Chemie, Biozentrum, ZAFES CMP, Max von Laue Strasse 9, 60438 Frankfurt, Germany
    Bioorg Med Chem Lett 19:538-42. 2009
    ..The 4-(3-piperidinopropoxy)phenyl pharmacophore moiety has been linked to amitriptyline, maprotiline, chlorpromazine, chlorprothixene, fluphenazine, and clozapine...
  58. doi Relationships among endocrine and signaling-related responses to antidepressants in human monocytic U-937 blood cells: analysis of factors and response patterns
    Stefan Gebhardt
    Department of Psychiatry and Psychotherapy, Philipps University of Marburg, Rudolf Bultmann Strasse 8, D 35033 Marburg, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 32:1682-7. 2008
    Antidepressants (AD) (desipramine, imipramine, maprotiline, mirtazapine) and corticosteroid (CS) were examined for their effects on gene expression in human monocytic U-937 blood cells...
  59. ncbi Determination of antidepressants in human postmortem blood, brain tissue, and hair using gas chromatography-mass spectrometry
    Sarah M R Wille
    Laboratory of Toxicology, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
    Int J Legal Med 123:451-8. 2009
    ..mirtazapine, viloxazine, venlafaxine, citalopram, mianserin, reboxetine, fluoxetine, fluvoxamine, sertraline, maprotiline, melitracen, paroxetine, desmethylfluoxetine, desmethylmianserin, desmethylmirtazapine, desmethylsertraline, ..
  60. ncbi Effect of long-term administration of antidepressants on the lipid composition of brain plasma membranes
    Z Fisar
    Department of Psychiatry, 1st Faculty of Medicine, Charles University, Ke Karlovu 11, 120 00 Prague 2, Czech Republic
    Gen Physiol Biophys 24:221-36. 2005
    ..Laboratory rats were given desipramine, maprotiline, citalopram, moclobemide or lithium for a 4-week period...
  61. ncbi A new method for simultaneous determination of cyclic antidepressants and their metabolites in urine using enzymatic hydrolysis and fast GC-MS
    Sumandeep Rana
    Redwood Toxicology Laboratory, Santa Rosa, California 95403, USA
    J Anal Toxicol 32:355-63. 2008
    ..used for quantitation of amitriptyline, nortriptyline, imipramine, desipramine, doxepin, desmethyldoxepin, and maprotiline in human urine, in addition to the qualitative determination of their hydroxylated metabolites...
  62. ncbi Antidepressant-like effects of neferine in the forced swimming test involve the serotonin1A (5-HT1A) receptor in mice
    Yumi Sugimoto
    Laboratory of Pharmacology, Department of Clinical Pharmacy, Yokohama College of Pharmacy, Matano cho, Totsuka ku, Yokohama, 245 0066, Japan
    Eur J Pharmacol 634:62-7. 2010
    ..dose effects of neferine in the forced swimming test were almost equal to those of the typical antidepressants maprotiline and imipramine. The involvement of the 5-HT receptor subtypes was also studied using 5-HT receptor antagonists...
  63. ncbi Lofepramine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness
    S G Lancaster
    ADIS Drug Information Services, Manchester, England
    Drugs 37:123-40. 1989
    ..overall therapeutic efficacy of lofepramine is comparable to that of imipramine, amitriptyline, clomipramine, maprotiline and mianserin in patients with depression of varying severity, and coexisting anxiety...
  64. ncbi Berberine produces antidepressant-like effects in the forced swim test and in the tail suspension test in mice
    Wen Huang Peng
    Graduate Institute of Chinese Pharmaceutical Sciences, College of Pharmacy, China Medical University, 91, Hsueh Shih Road, Taichung, Taiwan, ROC
    Life Sci 81:933-8. 2007
    ..the combination of the desipramine [DES, an inhibitor of reuptake of noradrenaline (NA) and serotonin (5-HT)], maprotiline (MAP, selective NA reuptake inhibitor), fluoxetine (FLU, selective 5-HT reuptake inhibitor) and moclobemide [..
  65. ncbi Semicarbazide-sensitive amine oxidase (SSAO) in the brain
    Toshio Obata
    Department of Pharmacology, Oita Medical University, Hasama, Japan
    Neurochem Res 27:263-8. 2002
    ..SSAO in monkey brain was observed by tricyclic antidepressant drug imipramine, as compared to tetracyclic drug maprotiline or non-cyclic drug nomifensine...
  66. ncbi Trimipramine, anxiety, depression and sleep
    J C Pecknold
    Douglas Research Center, Quebec, Canada
    Drugs 38:25-31; discussion 49-50. 1989
    ..Further controlled trials showed superior anxiolytic efficacy of trimipramine to amitriptyline and doxepin with comparable anxiolytic efficacy of trimipramine with maprotiline. All agents had equal antidepressant effects.
  67. ncbi Different pharmacological interaction of clonidine and guanabenz with antidepressive drugs
    J S Gutkind
    Catedra de Farmacologia, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina
    Clin Exp Hypertens A 9:1531-47. 1987
    ..The acute pretreatment (1 mg.kg-1) with desipramine (DMI), maprotiline (MAP) and mianserin (MIA) reduced the hypotensive and bradycardiac responses induced by CLO (10 micrograms...
  68. doi Psychotropic drugs associated with corrected QT interval prolongation
    Charlotte van Noord
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Clin Psychopharmacol 29:9-15. 2009
    ....
  69. ncbi [Effects of electroacupuncture on behavior, plasma COR and expressions of PKA and PKC in hippocampus of the depression model rat]
    Fan Lu
    Medical College, Xiamen University, Fujian, and Xiamen City Hospital of TCM, China
    Zhongguo Zhen Jiu 28:214-8. 2008
    ..To probe into the mechanism of acupuncture for treatment of depression...
  70. ncbi Paroxetine. An update of its pharmacology and therapeutic use in depression and a review of its use in other disorders
    N S Gunasekara
    Adis International Limited, Auckland, New Zealand
    Drugs 55:85-120. 1998
    ..those with placebo and similar to those achieved with other agents including tricyclic antidepressants (TCAs), maprotiline, nefazodone and the selective serotonin reuptake inhibitors (SSRIs) fluoxetine, fluvoxamine and sertraline...
  71. doi In vitro autoradiography and in vivo evaluation in cynomolgus monkey of [18F]FE-PE2I, a new dopamine transporter PET radioligand
    Andrea Varrone
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
    Synapse 63:871-80. 2009
    ..was observed in caudate and putamen that was selectively abolished by GBR12909 or beta-CIT but not by maprotiline. High doses of citalopram (>5 microM) also inhibited [18F]FE-PE2I binding in the striatum...
  72. ncbi Serotonin and noradrenaline reuptake inhibitors in animal models of pain
    Daisuke Mochizucki
    Asahi Kasei Pharma, Chiyoda ku, Tokyo, Japan
    Hum Psychopharmacol 19:S15-9. 2004
    ..formalin into the paw of a rodent, inhibitors of noradrenaline reuptake such as nisoxetine, nortriptyline and maprotiline and dual inhibitors of the noradrenaline and serotonin reuptake such as imipramine and milnacipran produce ..
  73. ncbi [Psychotropic drug-induced change of weight: a review]
    T Drieling
    Abt für Psychiatrie und Psychotherapie, Universitätsklinik für Psychiatrie und Psychosomatik Freiburg Direktor Univ Prof Dr med M Berger
    Fortschr Neurol Psychiatr 75:65-80. 2007
    ..The purpose of this study is to give a systematic review of change of weight associated with commonly used psychotropic drugs...
  74. ncbi The promises and pitfalls of reboxetine
    Michelle E Page
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    CNS Drug Rev 9:327-42. 2003
    ..b>Maprotiline, a non-tricyclic compound, is also a NE selective reuptake inhibitor...
  75. ncbi A clinical flow cytometric biomarker strategy: validation of peripheral leukocyte phospholipidosis using Nile red
    Bartley W Halstead
    Toxicology and Drug Disposition, A Division of Eli Lilly and Company, Greenfield, IN 46140, USA
    J Appl Toxicol 26:169-77. 2006
    ..Replicate studies with model test compounds were conducted in which F344 rats were given 4 or 7 doses of either maprotiline hydrochloride, imipramine hydrochloride, tilorone dihydrochloride, amikacin hydrate or vehicle control...
  76. ncbi [11C]LBT-999: a suitable radioligand for investigation of extra-striatal dopamine transporter with PET
    Wadad Saba
    CEA, Service Hospitalier Frederic Joliot, DRM DSV, Orsay, France
    Synapse 61:17-23. 2007
    ..v.) or the norepinephrine transporter antagonist maprotiline (5 mg/kg i.v.) had no effect on LBT specific binding. Pharmacological challenge with PE2I (1 mg/kg i.v...
  77. ncbi Tandem regulation of phosphoinositide signaling and acute behavioral effects induced by antidepressant agents in rats
    Kimberly R Tyeryar
    Laboratory of Integrative Neuropharmacology, Programs in Neuroscience and Molecular Medicine, Department of Pharmaceutical Sciences, University of Maryland, Baltimore, MD 21201 1075, USA
    Psychopharmacology (Berl) 193:271-82. 2007
    ..Thus, cross talk between antidepressant-induced CDP-diacylglycerol and 5HT(2) signaling could contribute to the antidepressant mechanism...
  78. doi Effects of repeated maprotiline and fluoxetine treatment on gene expression of catecholamine synthesizing enzymes in adrenal medulla of unstressed and stressed rats
    N Spasojevic
    Institute of Nuclear Sciences Vinca, Laboratory of Molecular Biology and Endocrinology, 11000 Belgrade, Serbia
    Auton Autacoid Pharmacol 30:213-7. 2010
    1 Repeated maprotiline (a noradrenaline reuptake inhibitor) and fluoxetine (a serotonin reuptake inhibitor) treatment on gene expression of catecholamine biosynthetic enzymes were examined in adrenal medulla of unstressed control and ..
  79. ncbi Antidepressant-like effects of mild hypoxia preconditioning in the learned helplessness model in rats
    Elena Rybnikova
    Laboratory of Neuroendocrinology, Pavlov Institute of Physiology, Russian Academy of Sciences, Makarova 6, 199034 St Petersburg, Russian Federation
    Neurosci Lett 417:234-9. 2007
    ..The findings suggest hypoxic preconditioning as an effective tool for the prophylaxis of post-stress affective pathologies in humans...
  80. ncbi Mood disorders in patients with epilepsy: epidemiology and management
    Cynthia L Harden
    Comprehensive Epilepsy Center, Weill Medical College of Cornell University, New York, New York 10021, USA
    CNS Drugs 16:291-302. 2002
    ..Among these agents, citalopram has a low risk of interactions with AEDs. Bupropion, clomipramine and maprotiline are associated with a greater risk of seizures compared with other antidepressants and consequently should be ..
  81. ncbi Inhibition of monoamine oxidase within monoaminergic neurons in the rat brain by (E)-beta-fluoromethylene-m-tyrosine (MDL 72394)
    I Fagervall
    Department of Neuropharmacology, Astra Alab AB, Sodertalje, Sweden
    J Neurochem 52:467-71. 1989
    ..or [14C]dopamine (DA) in the absence and presence of the selective amine uptake inhibitors citalopram (5-HT), maprotiline (NA), and GBR 12909 (DA)...
  82. ncbi Duration and adherence of antidepressant treatment (2003 to 2007) based on prescription database
    M C Serna
    Regional Primary Care Management Office, Catalan Institute of Health, University of Lleida, Lleida, Spain
    Eur Psychiatry 25:206-13. 2010
    ..Many patients discontinue antidepressant therapy long before the six-month minimum duration recommended for the treatment of major depression and many other diagnoses...
  83. ncbi Is iprindole an indirect betamimetic drug?
    H Ganry
    Laboratoire de Pharmacologie, Faculte de Medecine, Nantes, France
    Neuropsychobiology 20:187-93. 1988
    ..In an acute dose, iprindole potentiates the effect of maprotiline on yohimbine toxicity...
  84. doi Pharmacological and neurochemical characterization of the involvement of hippocampal adrenoreceptor subtypes in the modulation of acute limbic seizures
    Ralph Clinckers
    Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Research Group Experimental Pharmacology, Vrije Universiteit Brussel, Brussels, Belgium
    J Neurochem 115:1595-607. 2010
    ..The noradrenaline reuptake inhibitor maprotiline mediated anticonvulsant effects, associated with dose-dependent increases in extracellular hippocampal ..
  85. ncbi Cytochrome P450 enzymes contributing to demethylation of maprotiline in man
    Lars Brachtendorf
    Institute for Pharmacology, Clinical Pharmacology, University of Koln, Germany
    Pharmacol Toxicol 90:144-9. 2002
    From case reports of patients treated with the tetracyclic antidepressant drug maprotiline, it appears that this drug is subject to polymorphic metabolism...
  86. ncbi The anxiolytic-like effect of MCI-225, a selective NA reuptake inhibitor with 5-HT3 receptor antagonism
    J Eguchi
    Pharmaceuticals Research Laboratory I, Yokohama Research Center Mitsubishi Tokyo Pharmaceuticals, Inc, Yokohama, Japan
    Pharmacol Biochem Behav 68:677-83. 2001
    ..this study, we investigated the effect of MCI-225 in anxiety models in comparison with diazepam, ondansetron, maprotiline, imipramine, and trazodone. In social interaction (SI) test in rats, MCI-225 (10 and 30 mg/kg, p.o...
  87. ncbi Epileptogenic drugs: a systematic review
    Claudio Ruffmann
    Centro per l Epilessia e Clinica Neurologica, Università Bicocca, Monza, Milan, Italy
    Expert Rev Neurother 6:575-89. 2006
    ..Drugs with intermediate epileptogenic potential include propofol, maprotiline, tricyclic antidepressants and chlorambucil...
  88. pmc Neuroprotective effects of psychotropic drugs in Huntington's disease
    Edward C Lauterbach
    Department of Psychiatry and Behavioral Sciences, Mercer University School of Medicine, 655 First Street, Macon, GA 31201, USA
    Int J Mol Sci 14:22558-603. 2013
    ..mitochondrial protection (haloperidol, trifluoperazine, imipramine, desipramine, nortriptyline, maprotiline, trazodone, sertraline, venlafaxine, melatonin), neurogenesis (lithium, valproate, fluoxetine, sertraline), and ..
  89. ncbi [The feasible applications of hypoxic preconditioning for prevention of post-stress depressive episodes]
    E A Rybnikova
    Zh Nevrol Psikhiatr Im S S Korsakova 107:43-8. 2007
    ....
  90. ncbi [Evaluation of antidepressant activity in a model of depressionlike state due to social isolation in rats]
    P D Shabanov
    Eksp Klin Farmakol 68:11-5. 2005
    ..A comparative study of three antidepressants with different mechanism of action (maprotiline, fluoxetine, tianeptine) on this model showed that tianeptine possessed the most pronounced antidepressant ..
  91. pmc Quantitative microtiter fibronectin fibrillogenesis assay: use in high throughput screening for identification of inhibitor compounds
    Bianca R Tomasini-Johansson
    University of Wisconsin Madison, Department of Biomolecular Chemistry and Medicine, Madison, WI 53706, United States
    Matrix Biol 31:360-7. 2012
    ..to inhibit FN assembly; two (piperlongumine and cantharidin) are promoters of cancer cell apoptosis; and three (maprotiline, CGS12066B, and aposcopolamine) are modulators of biogenic amine signaling...
  92. ncbi Tricyclic antidepressants as long-acting local anesthetics
    Yukari Sudoh
    Department of Anesthesia, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115 USA
    Pain 103:49-55. 2003
    Amitriptyline, nortriptyline, imipramine, doxepin, desipramine, protriptyline, trimipramine, and maprotiline are tricyclic antidepressants (TCAs) used orally in treating major depressive disorders...
  93. ncbi [A case of major depressive disorder barely distinguishable from narcissistic personality disorder]
    Shinnosuke Saito
    Department of Psychiatry, Jichi Medical University
    Seishin Shinkeigaku Zasshi 115:363-71. 2013
    ..treatment, mainly with supportive psychotherapy and pharmacotherapy including antidepressants (high dose of maprotiline combined with low dose of mirtazapine), sodium valprote and aripiprazole, finally improved not only his ..
  94. pmc Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease
    Tie Shan Tang
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 102:2602-7. 2005
    ..and can be prevented by MPTP blockers such as bongkrekic acid, Nortriptyline, Desipramine, Trifluoperazine, and Maprotiline. These findings describe a pathway directly linking disturbed Ca2+ signaling and degeneration of MSN in the ..
  95. pmc Social phobia following maprotiline: the first case report
    Seyed Hamzeh Hosseini
    Department of Psychiatry, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran
    Cases J 2:9340. 2009
    ..The aim of this report is to present a patient who experienced social phobia following maprotiline, an adverse drug reaction which has not been reported previously with this agent.
  96. doi Glucose dysregulation associated with antidepressant agents: an analysis of 17 published case reports
    Star Khoza
    College of Pharmacy, The University of Texas at Austin, 1 University Station A1900, Austin, TX 78712, USA
    Int J Clin Pharm 33:484-92. 2011
    ..The aim of this review is to provide a descriptive analysis of the demographic and clinical characteristics of published glucose dysregulation case reports following initiation of antidepressant agents...
  97. ncbi Do alpha2-adrenoceptors play an integral role in the antinociceptive mechanism of action of antidepressant compounds?
    A M Gray
    Department of Pharmacology, The Welsh School of Pharmacy, Cardiff University, Wales, UK
    Eur J Pharmacol 378:161-8. 1999
    ..It is probable, however, that other differing pharmacological properties of some antidepressants, such as opioid-like activity, may complicate any empirical correlation between monoamine uptake and analgesia...
  98. doi TMD chronic pain and masseter silent period in psychiatric patients on antidepressive therapy
    N Ivkovic
    Division of Prosthodontics, Faculty of Dentistry, University of East Sarajevo, Republic of Srpska, Bosnia and Herzogovinia
    J Oral Rehabil 35:424-32. 2008
    ..hospitalized psychiatric depressive patients on antidepressive therapy protocol (tetracyclic antidepressant-maprotiline and anxiolytic-diazepam) (n=30) and non-psychiatric patients seeking prosthodontic treatment (control group, n=..
  99. ncbi Perceived parenting pattern and response to antidepressants in patients with major depression
    K Sakado
    Department of Psychiatry, Niigata University School of Medicine, Niigata, Japan
    J Affect Disord 52:59-66. 1999
    ....
  100. pmc Diverse antidepressants increase CDP-diacylglycerol production and phosphatidylinositide resynthesis in depression-relevant regions of the rat brain
    Kimberly R Tyeryar
    Department of Pharmaceutical Sciences, Jefferson School of Pharmacy, Thomas Jefferson University, Philadelphia, PA 19107, USA
    BMC Neurosci 9:12. 2008
    ..measured in response to the tricyclics desipramine and imipramine, the selective serotonin reuptake inhibitors fluoxetine and paroxetine, the atypical antidepressants maprotiline and nomifensine, and several monoamine oxidase inhibitors.
  101. ncbi Older versus newer antidepressants: substance P or calcium antagonism?
    C Boselli
    Department of Experimental and Applied Pharmacology, School of Pharmacy, University of Pavia, Viale Taramelli 14, 27100 Pavia, Italy
    Can J Physiol Pharmacol 85:1004-11. 2007
    ..Clomipramine, fluoxetine, maprotiline, and amitriptyline (all at 3 mumol/L) flattened the concentration-response curves to SP, resulting in a ..

Research Grants10

  1. HORMONE REPLACEMENT IN MENOPAUSAL WOMEN WITH EPILEPSY
    Cynthia Harden; Fiscal Year: 2000
    ..The outcome of this study will be determined by comparing seizure frequency in the baseline phase with the treated phase between placebo and hormone treated groups. ..
  2. Role of norepinephrine and the amygdala in drug relapse
    MATTHEW FELTENSTEIN; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  3. Radiotracer R and D in Nuclear Medicine and Neuroscience
    Yu Shin Ding; Fiscal Year: 2006
    ..abstract_text> ..
  4. BETTER ANTIRETROVIRAL ADHERENCE: HIV+ AMPHETAMINE USERS
    J Atkinson; Fiscal Year: 2003
    ....
  5. HORMONE REPLACEMENT IN MENOPAUSAL WOMEN WITH EPILEPSY
    Cynthia Harden; Fiscal Year: 2002
    ..The outcome of this study will be determined by comparing seizure frequency in the baseline phase with the treated phase between placebo and hormone treated groups. ..
  6. BETTER ANTIRETROVIRAL ADHERENCE: HIV+ AMPHETAMINE USERS
    J Atkinson; Fiscal Year: 2002
    ....
  7. HORMONE REPLACEMENT IN MENOPAUSAL WOMEN WITH EPILEPSY
    Cynthia Harden; Fiscal Year: 2001
    ..The outcome of this study will be determined by comparing seizure frequency in the baseline phase with the treated phase between placebo and hormone treated groups. ..
  8. BETTER ANTIRETROVIRAL ADHERENCE: HIV+ AMPHETAMINE USERS
    J Atkinson; Fiscal Year: 2001
    ....
  9. BETTER ANTIRETROVIRAL ADHERENCE: HIV+ AMPHETAMINE USERS
    J Atkinson; Fiscal Year: 2000
    ....
  10. Radiotracer R and D in Nuclear Medicine and Neuroscience
    Yu Shin Ding; Fiscal Year: 2005
    ..abstract_text> ..