plant extracts

..In addition, potato peel and beetroot peel extracts showed strong antioxidant effects. To utilize these significant sources of natural antioxidants, further characterization of the phenolic composition is needed...

..Traditional Chinese medicinal plants associated with anticancer might be potential sources of potent natural antioxidants and beneficial chemopreventive agents...

Natural products, either as pure compounds or as standardized plant extracts, provide unlimited opportunities for new drug leads because of the unmatched availability of chemical diversity...

..longiflora, whereas quercetin-3-O-rhamnosyl-(1 --> 2)-rhamnosyl-(1 --> 6)-glucoside and kaempferol-3-O-rhamnosyl-(1 --> 2)-rhamnosyl-(1 --> 6)-glucoside were predominant phenolic compounds in Ginkgo biloba leaves...

..However, much work is still to be done to standardize methods and cut-off points for describing the antimicrobial activity, and on the study of the mechanisms of action...

..Total phenolic contents in plant extracts were estimated and different amounts of phenolic contents were found in B. variegata, T. cardifolia and P...

..The paper also presents some data on the use of plant products in the development of functional foods, addresses the needs for validation of plant extracts and always stressing on safety, efficacy and quality of phyto-medications.

Agar diffusion techniques are used widely to assay plant extracts for antimicrobial activity, but there are problems associated with this technique...

..The aim of this review is to summarize findings of beneficial properties of GML's extracts and xanthones isolated from this plant so far...

..This new generation of phytopharmaceuticals could lend phytotherapy a new legitimacy and enable their use to treat diseases which have hitherto been treated using synthetic drugs alone...

..Eventually, LE and FE were found to inhibit violacein production, a QS-regulated behavior in Chromobacterium violaceum 12472...

..In this paper, we report on the rapid synthesis of silver nanoparticles by reduction of aqueous Ag(+) ions using D. bulbifera tuber extract...

..The superior bioactivity of PJ compared to its purified polyphenols illustrated the multifactorial effects and chemical synergy of the action of multiple compounds compared to single purified active ingredients...

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Brazilian plant extracts belonging to 16 species of 5 different families (71 extracts) were tested against the stable DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) free-radical...

..The length of human intervention studies should be increased, to more closely reflect the long-term dietary consumption of polyphenols...

The development of the biological synthesis of nanoparticles using microorganisms or plant extracts plays an important role in the field of nanotechnology as it is environmentally friendly and does not involve any harmful chemicals...

..They are quantitatively characterised plant extracts supplying a high concentration of actives and therefore can be used for development of phytopharmaceutical ..

..The most needed outcome of this work will be the development of value-added products from C. longa for biomedical and nanotechnology-based industries...

..The study aimed to test the activity of Terminalia catappa L. against bacterial quorum sensing (QS) in order to provide a potential scientific basis for the traditional use of leaf extracts of this plant as an antiseptic...

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..8 +/- 0.4 microM and 22.7 +/- 2.8 microM, respectively). These results support the use of this plant for the treatment of hepatitis in oriental traditional medicine...

..This included a network of proteins involved in metabolism, regulation of the cell cycle, and transcription-factor activity...

..Together, these results suggest that HO1 plays, at least in part, an important role in the neuroprotective mechanism of EGb 761 and in delayed ischemia. Targeting this pathway could lead to neuroprotective agents against ischemic stroke...

..These results indicate that AGE increased NO production by activating cNOS, but not iNOS. The arginine contained in AGE was not responsible for the effect. AGE may be a useful tool for the prevention of cardiovascular disease...

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..Owing to this property, the studies can be further extended to exploit them for their possible application for the preservation of food products as well as their use as health supplements and neutraceuticals...

..59 microM). The Malaysian Alpinia galanga showed weak activity compared with the Thai sample and this was shown to be due to the relatively high amounts of 1'-acetoxychavicol acetate present in the Thai sample...

..These data support the hypothesis that fucoidan may have potential in colon cancer treatment...

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..Finally, possible mechanisms of action involving antioxidant and pro-oxidant activity as well as interference with cellular functions are discussed...

..The purpose of this study was to search for a novel quorum sensing inhibitor and analyse its inhibitory activity...

..On the basis of the ORAC results, green pepper, spinach, purple onion, broccoli, beet, and cauliflower are the leading sources of antioxidant activities against the peroxyl radicals...

..The characterized nanoparticles of M. edule have potential for various medical and industrial applications. Saponin presence in aqueous extract of M. edule is responsible for the mass production of silver and gold nanoparticles...

..FCB was found to be more active than FCR on most of the tested organisms. The results provided evidence that the studied plants extract, as well as some of the isolated compounds might be potential sources of new antimicrobial drug...

..It would appear that the beneficial effects of the use of the seeds and thymoquinone might be related to their cytoprotective and antioxidant actions, and to their effect on some mediators of inflammation...

..Of the 78 different plant extracts investigated, 80% showed activity against both Gram-positive and Gram-negative bacteria in the disc-diffusion ..

..Isolation studies of saponins were examined to determine which are the more commonly studied plant families and in which families saponins have been identified...

..GC-MS analysis of the chemical composition of the essential oil from leaves showed a total of 44 compounds. Isolated extracts could be of use for the future development of anti-skin disease agents...

..potentially useful medicinal plants and herbs waiting to be evaluated and exploited for therapeutic applications against genetically and functionally diverse viruses families such as Retroviridae, Hepadnaviridae and Herpesviridae..

..Fagaceae). This study introduces not only a new mode of action and possible validation for traditional plant use, but also a potentially new therapeutic direction for the treatment of bacterial infections...

..tamala leaf extracts have potential to prevent growth of food spoilage/pathogenic fungi. In addition they also have capability to mitigate the oxidative stress by antioxidant response...

..somnifera mediated through up-regulation of liver LRP indicates that targeting the periphery offers a unique mechanism for Aβ clearance and reverses the behavioral deficits and pathology seen in Alzheimer's disease models...

..These findings suggest that flavonoid glycosides cannot activate PPARgamma, whereas some of their aglycones are potential agonists of PPARgamma...

..The CAA assay is a more biologically relevant method than the popular chemistry antioxidant activity assays because it accounts for some aspects of uptake, metabolism, and location of antioxidant compounds within cells...

..A bioassay-guided fractionation was carried out in order to evaluate the anti-malarial potential and the safety of the methanol extract of the Hypericum lanceolatum stem bark...

..001). Taken together, these findings suggest that edible red algae Gracilaria water extract can prevent H₂O₂-induced oxidative DNA damage and its related cellular responses...

..These results demonstrate that GSPE provides excellent protection against oxidative stress and free radical-mediated tissue injury...

..Specifically, the literature was reviewed for articles pertaining to chemical properties, therapeutic benefits, and toxicity...

..To assess the effect, tolerability and acceptability of aged garlic extract as an adjunct treatment to existing antihypertensive medication in patients with treated, but uncontrolled, hypertension...

..The BI could be a new alternative biomarker for future epidemiological studies in dietary cancer prevention and health promotion...

..The high content of phenolic compounds, antioxidant activity, and antiproliferative activity of apple peels indicate that they may impart health benefits when consumed and should be regarded as a valuable source of antioxidants...

..With these studies, we suggest that combinative therapy of GB and cilostazol might offer enhanced anti-thrombotic efficacies without increasing side-effects...

..05). Results from this study may provide insight into a possible molecular mechanism underlying GbE suppression of the oxLDL-mediated vascular endothelial dysfunction...

..Chebulinic acid (IC(50) = 53.2 microM +/- 0.16) > tannic acid (IC(50) = 59.0 microg/ml +/- 0.19) > and ellagic acid (IC(50) = 78.5 microM +/- 0.24), were the most growth inhibitory phenolics of T. chebula fruit in our study...

..Bioactivity screening of East African medicinal plant extracts using fli-1:EGFP transgenic zebrafish embryos identified Oxygonum sinuatum and Plectranthus barbatus as ..

..The aim of this study was to investigate the antibiofilm and antibacterial activities of 45 aqueous extracts from 24 Caatinga plant species...

..Our data suggest that cucurbitacin B may in part induce apoptosis and exert growth inhibitory effect via interruption the Wnt signaling...

..This review summarizes the phytochemical, pharmacological and pharmacokinetics data, together with the clinical and adverse effects of licorice and its bioactive components...

..Although higher extract yields were obtained by the refluxing extraction technique, in general higher amounts of total phenolic contents and better antioxidant activity were found in the extracts prepared using a shaker...

..More studies are required in animals and humans on the kinetics of ginger and its constituents and on the effects of their consumption over a long period of time...

..The aim of this review is to illustrate the recent advances in the isolation and analysis of ginseng, and to highlight new applications and challenges. Emphasis is placed on recent trends and emerging techniques...

..The most potent antimicrobial plant was A. nilotica (MIC range 9.75-313 microg/ml), whereas other crude plant extracts studied in this report were found to exhibit higher MIC values than A...

..The anisotropy in nanoparticle shape results in large near-infrared absorption by the particles, and highly anisotropic electron transport in films of the nanotriangles...

..These results were statistically significant. It is concluded that TT extract appears to possess aphrodisiac activity probably due to androgen increasing property of TT (observed in our earlier study on primates)...

..Andrographolide showed anticancer activity on diverse cancer cells representing different types of human cancers. Whereas all the three molecules showed enhanced proliferation and interleukin-2 (IL-2) induction in HPBLs...

..There are few reports available on clinical use of MC in diabetes and cancer patients that have shown promising results...

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..The body fat reducing effect and reduction of risks for cardiovascular disease by a green tea extract (GTE) high in catechins was investigated in humans with typical lifestyles...

..Such preparations will be useful for studies in experimental animals and humans...

..The present work constitutes a review of the literature on plant extracts and chemically defined molecules of natural origin showing antileishmanial activity...

..This method represents a clear advantage because it extensively reduces sample preparation and total time for routine analysis of phytohormones in real plant samples...

..Reduction of silver ions by Aloe vera extract however, led to the formation of spherical silver nanoparticles of 15.2 nm +/- 4.2 nm size...

..6 (P<0.0001) and 2.2-fold (P=0.001), respectively. We suggest that pomegranate extract could be particularly promising in dietary prevention of intestinal inflammation...

..This study also represents an important advance in the use of plants over microorganisms in the biosynthesis of metal nanoparticles...

..The TPC were 487.9 +/- 927.8 microg gallic acid equivalents/g of grain. No correlation was observed between TPC and radical scavenging capacities for DPPH* and ABTS*+ (p = 0.15 and p > 0.5, respectively)...

..OF THE STUDY: The knowledge of extent and mode of inhibition of specific compounds, which are present in plant extracts, may contribute to the successful application of such natural preservatives in foods, since certain ..

..This antidiabetic effect of ginsenoside Re was not associated with body weight changes, suggesting that other constituents in the extract have distinct pharmacological mechanisms on energy metabolism...

..This review discusses the history, future, scientific background and regulatory issues related to botanical therapeutics...

..Thus, it indicates that this substance can show different activities and has potential for cancer chemoprevention which were dose dependent as well as exposure time dependent...

..CAPE, used alone, exhibited a strong antioxidant activity, higher than galangin. The experimental evidence, therefore, suggests that CAPE plays an important role in the antioxidant activity of propolis...

..A bioactivity index (BI) for dietary cancer prevention is proposed to provide a new alternative biomarker for future epidemiological studies in dietary cancer prevention and health promotion...

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..This review summarizes the effect of polyphenols on inflammation and cancer; avenanthramides, a unique polyphenol from oats, are especially focused...

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..Other potential applications include infant brain ischemia, male infertility, Alzheimer's disease, arthritis, and obesity...

..aureus (98-389 microg/ml) and the genus Vibrio (68-488 microg/ml) were similar. The relatively lower mean MIC values of 1, 2, 5, and 6 suggest the importance of 3,4,5-trihydroxyphenyl groups in antibacterial activity...

..These results suggest that CSE had an antiobesity effect via elevated β-oxidation and lipolysis in adipose tissue...

..The traditional healers are dwindling in number and there is a grave danger of traditional knowledge disappearing soon since the younger generation is not interested to carry on this tradition...

..These results were comparable with those obtained with curcumin (100 mg/kg, p.o.)...

..The present review discusses the most promising findings from studies of these plant families...

..5. With SI values greater than 200, the potential use of ursolic acid for treating infection with CVB1 and EV71 merits further investigation...

..Experiments proved different pharmacological characteristics of R. rosea and R. crenulata: R. rosea is most effective for improving physical working capacity...

..This study shows that the presence of natural compounds that exhibit anti-quorum sensing activity in the clove extracts may be useful as the lead of anti-infective drugs...

..Our findings illustrate and elucidate the antidiabetic/insulin mimetic effects of Trigonella, manganese and vanadium...

..01-103.09h*N/cm2 and was completely above the margin of non-inferiority. Moreover, the results of the primary and secondary variables indicate that Comfrey extract may be superior to Diclofenac gel...

..Hence, while there is a great deal of moderately good-quality scientific data regarding E. purpurea, effectiveness in treating illness or in enhancing human health has not yet been proven beyond a reasonable doubt...

..e., reducing the risk of cardiovascular disease, stroke, cancer and aging, including the oxidant-mediated brain cell damage that is implicated in Alzheimer's disease...

..Lately a there is a lot of interest in the analysis of the undesired alkylphenols and a few validated procedures have been published. The analysis of Ginkgo proanthocyanidins is still in its infancy and no reliable assays exist...

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..WEN also showed antimicrobial activity against nine microorganisms, antiulcer activity against ethanol-induced ulcerogenesis and analgesic effect on acetic acid-induced stretching...

..Solenace plant extracts will be produced and analyzed to identify and quantify alkaloids and to determine dose-response ..

..To test this hypothesis, we screened over 50 plant extracts used in Traditional Chinese Medicine for tissue selective ERa activity...

..parental and fractionated extracts derived from botanicals and purified small molecule phytochemicals from plant extracts provided by CDex...

..I have used both of these methods to test the beneficial properties of other well standardized herbal plant extracts and their bioactive components against stroke...

..Preliminary studies provide strong support for nature-derived agents, in particular polyphenol-rich plant extracts, which strongly enhance dentin matrix properties and positively impact the dentin-resin bonds...

..bioactivity-directed fractionation and isolation to identify breast cancer-selective compounds starting from plant extracts with confirmed activity and counter-screened in-house on the basis of susceptibility to breast cancer cell ..

..and elucidate the composition, chemical identity, and bioactivity of fractions and compounds from antimalarial plant extracts with the highest in vitro activity and low toxicity...

..R21 proposal aims to isolate, identify and further characterize the active components of these four validated plant extracts and an additional 10 extracts that will be selected from secondary screening of 46 additional crude extracts ..

..of Nui Chua National Park NCNP (Vietnam), marine biodiversity of South China Sea, and UIC-ICBG Phase II legacy plant extracts;(ii) discovery of new cellulose-degrading and biofuel-producing microbial strains;(iii) advancing new ..

..About {20%} of these plant extracts have been screened so far to validate its traditional medical use with behavioral tests in mice...

..supplements, scientific studies to understand the biological properties of the compounds present in these plant extracts are limited and efficacy of many of the supplements is unclear...

..Increasing attention has been paid to plant extracts (or phytotherapy) use by patients to self-treat medical ailments such as BPH...

..study of CAM effects on innate leukocytes and epithelial cells, purification of defined agonists from crude plant extracts, use of probiotic CAMs, and use of rodent models of infectious and inflammatory disease to define specific ..

..Ms. Powell's main goal will be to investigate a variety of plant extracts and active compounds to evaluate their serotonergic activity ...

..system is exemplified in a preliminary HTS study, in which we identified a novel small molecule derived from plant extracts that rescues CFTRdeltaF508 misfolding...

..The specific aims of this project are: 1) To develop chemical fingerprints of five West African plant extracts (neem tree, baobab tree, Senegal mahogany, African basil, and kinkirissi bush) as initial quality control ..

..b>Plant extracts and chromatographic fractions will be monitored for sweetness using previously established gerbil ..

..aims are (1) Use a 96-well cytotoxicity assay against a panel of selected breast cancer cell lines to screen plant extracts for those with potent inhibition or killing of cells; (2) Use an innovative high-throughput genetic-based ..

..1) Bioactivity-directed fractionation and isolation of the active principles from 30 high priority plant extracts will be continued...

..Micro-organisms will also be isolated from these materials and screened for antinfective activity. To screen plant extracts and compounds derived from terrestrial and marine environments for anti-infective, CNS, anti-cancer, ..

..Expertise of the research team in the characterization of complex plant extracts using mass spectrometry will be essential to accomplishing this goal...

..To test this hypothesis, plant extracts of varying polarity will be prepared from Echinacea purpurea and Spilanthes acmella plant material that has ..

..I have used both of these methods to test the beneficial properties of other well standardized herbal plant extracts and their bioactive components against stroke...

..Our plan of attack in this proposal is: (a) to screen our collection of tropical rainforest plant extracts for killing of the parasites in culture, (b) to test our extracts for inhibition of some key enzymes necessary ..

..After confirming the usefulness and reproducibility of the assay, we will profile a small library of plant extracts from the Philippines...

..assays of cytotoxicity in human KB cell lines resistant to topoisomerase II inhibitors for selection of plant extracts and assays for protein-linked DNA breaks (PLDB), inhibition of etoposide (VP-16)-induced PLDB and inhibition ..

..chromatography coupled with mass spectrometry) were developed to identify these lipid metabolites in crude plant extracts and in industrially-refined vegetable oil fractions...

..A non-infectious whole HI V-virus replication assay will be employed to test plant extracts for anti-HIV activity, and to guide the isolation of the active components...

..approach to the chemical synthesis of (+)- sesbanimide A (3), a potent cytotoxic agent isolated from plant extracts of Sesbania drummundii seed, and six structurally related analogues is proposed...

..H. Lee of the University of North Carolina at Chapel Hill to discover such compounds by screening plant extracts for HIV inhibitors, then designing synthetic analogs with improved antiviral and solubility properties...

..While the source of these compounds is from plant extracts, a suitable synthetic route would be preferable| The work outlined herein will greatly assist with the ongoing ..

..These natural products are derived from plant extracts that are currently used for traditional medicine, so it is likely that there mammalian toxicity is quite low...

Work will be continued to characterize chemically various fractions and subfractions of cannabis plant extracts and smoke condensates. Comparative studies are simultaneously carried out with tobacco as a "baseline material"...

..A screen of 3200 plant extracts led to the identification of seven active principles, none of which had previously been shown to affect the ..

..of anticancer agents active against the major solid tumors of man During the past 5 years, nearly 4000 crude plant extracts, from the laboratory of Dr Joseph Hoffmann at the University of Arizona, have been evaluated for solid tumor ..

..The aims are to develop rapid screening procedures of Candida proteases from plant sources, evaluate plant extracts for protease inhibition, isolate and structurally characterize inhibitors from active plant extracts, ..

..It will provide a simple means by which a large panel of drugs, plant extracts, foodstuffs, etc. can be screened rapidly for estrogenic or antiestrogenic (ie, anticancer) activity...

..A manual of procedures will be generated to assist others in replicating the intervention. ..

..We do not anticipate that Mg supplementation will replace conventional treatment, but may complement and decrease the need for conventional medications. ..

..This information may also be useful for therapeutic research investigating the potential use of mGluR ligands in age-related neurodegenerative disorders, such as Alzheimer's disease. ..

..In phase 3, potential products will be commercialized with a partner specializing in pharmaceutical natural products. ..

..The resulting data may provide insight on the relative contributions of the different ARI's in an in vivo model, and may support evaluation of new approaches to enhance axon regeneration after CNS injury. ..

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..This new insight into the signaling mechanism of AAP-induced cell death holds the promise of establishing novel therapeutic approaches for preventing AAP-induced liver failure and potentially other forms of drug toxicity in humans. ..

..pylori strains. Active extracts will be utilized for in vivo studies. The long-term objectives are to develop safe and effective botanical extracts for the treatment and prevention of H. pylori infections. ..

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..Our long-range goals are to improve the quality of black cohosh dietary supplements and understand the variation in Actaea species. ..

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..In addition, the time course of the appearance of cytoplasmic cytochrome C and the activation of cellular caspases will be determined by antibody-based techniques, immunocytochemistry and enzymatic analysis. ..

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