suppositories

Summary

Summary: Medicated dosage forms that are designed to be inserted into the rectal, vaginal, or urethral orifice of the body for absorption. Generally, the active ingredients are packaged in dosage forms containing fatty bases such as cocoa butter, hydrogenated oil, or glycerogelatin that are solid at room temperature but melt or dissolve at body temperature.

Top Publications

  1. ncbi A two-way cross-over bioequivalence study comparing two products of diclofenac sodium suppositories in healthy human volunteers
    Mazen Hasan
    Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan
    Basic Clin Pharmacol Toxicol 95:263-5. 2004
  2. ncbi Rectal analgesia for the relief of perineal pain after childbirth: a randomised controlled trial of diclofenac suppositories
    Jodie M Dodd
    Maternal and Perinatal Clinical Trials Unit, Department of Obstetrics and Gynaecology, The University of Adelaide, Women s and Children s Hospital, North Adelaide, South Australia, Australia
    BJOG 111:1059-64. 2004
  3. ncbi Comparative absorption of 5-aminosalicylic acid (5-ASA) after administration of a 5-ASA enema and salazosulfapyridine (SASP) after an SASP suppository in Japanese volunteers
    Kenji Tokui
    Department of Pharmacy, Nagoya Daini Red Cross Hospital, Japan
    Biol Pharm Bull 25:264-7. 2002
  4. ncbi Symptom control in cancer patients: the clinical pharmacology and therapeutic role of suppositories and rectal suspensions
    Mellar P Davis
    Harry R Horvitz Center for Palliative Medicine, 9500 Euclid Avenue R35, Cleveland OH 44195, USA
    Support Care Cancer 10:117-38. 2002
  5. ncbi Serum paracetamol concentrations in adult volunteers following rectal administration
    M E Stocker
    Department of Anaesthesia, South Devon Healthcare Trust, Torquay, UK
    Br J Anaesth 87:638-40. 2001
  6. ncbi Investigation of product quality between extemporaneously compounded progesterone vaginal suppositories and an approved progesterone vaginal gel
    Vorapann Mahaguna
    PharmaForm, LLC, Austin, TX 78758, USA
    Drug Dev Ind Pharm 30:1069-78. 2004
  7. doi Sumatriptan (50 mg tablets vs. 25 mg suppositories) in the acute treatment of menstrually related migraine and oral contraceptive-induced menstrual migraine: a pilot study
    Fabio Facchinetti
    UCADH Section Psychobiology of Reproduction, Mother Infant Dept, Univ of Modena and Reggio Emilia, Emilia, Modena, Italy
    Gynecol Endocrinol 26:773-9. 2010
  8. pmc Pre-referral rectal artesunate to prevent death and disability in severe malaria: a placebo-controlled trial
    M F Gomes
    UNICEF UNDP World Bank WHO Special Programme for Research and Training in Tropical Diseases, Geneva, Switzerland
    Lancet 373:557-66. 2009
  9. doi A prospective randomized single blind trial of Fleet phosphate enema versus glycerin suppositories as preparation for flexible sigmoidoscopy
    D Underwood
    Department of Surgery, Altnagelvin Area Hospital, Glenshane Road, Londonderry BT47 6SB, Northern Ireland, UK
    Ir J Med Sci 179:113-8. 2010
  10. ncbi A rapid micro quantification method of paracetamol in suppositories using differential scanning calorimetry
    Mohamed I Noordin
    Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Drug Dev Ind Pharm 30:925-30. 2004

Detail Information

Publications188 found, 100 shown here

  1. ncbi A two-way cross-over bioequivalence study comparing two products of diclofenac sodium suppositories in healthy human volunteers
    Mazen Hasan
    Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan
    Basic Clin Pharmacol Toxicol 95:263-5. 2004
    ..00+/-0.09 with a 95% confidence limits (C.L.) of 0.82-1.18. Thus, these findings clearly indicate that the two products are bioequivalent in terms of rate and extent of drug absorption...
  2. ncbi Rectal analgesia for the relief of perineal pain after childbirth: a randomised controlled trial of diclofenac suppositories
    Jodie M Dodd
    Maternal and Perinatal Clinical Trials Unit, Department of Obstetrics and Gynaecology, The University of Adelaide, Women s and Children s Hospital, North Adelaide, South Australia, Australia
    BJOG 111:1059-64. 2004
    ..To evaluate rectal diclofenac in the relief of perineal pain after trauma during childbirth...
  3. ncbi Comparative absorption of 5-aminosalicylic acid (5-ASA) after administration of a 5-ASA enema and salazosulfapyridine (SASP) after an SASP suppository in Japanese volunteers
    Kenji Tokui
    Department of Pharmacy, Nagoya Daini Red Cross Hospital, Japan
    Biol Pharm Bull 25:264-7. 2002
    ..In the present study, we prepared suppositories containing 6.5 mmol of SASP and an enema containing 6.5 mmol of 5-ASA...
  4. ncbi Symptom control in cancer patients: the clinical pharmacology and therapeutic role of suppositories and rectal suspensions
    Mellar P Davis
    Harry R Horvitz Center for Palliative Medicine, 9500 Euclid Avenue R35, Cleveland OH 44195, USA
    Support Care Cancer 10:117-38. 2002
    ..In this review the pharmacology of rectally administered palliative medications is reviewed and the use of individual drugs is outlined...
  5. ncbi Serum paracetamol concentrations in adult volunteers following rectal administration
    M E Stocker
    Department of Anaesthesia, South Devon Healthcare Trust, Torquay, UK
    Br J Anaesth 87:638-40. 2001
    ..We conclude that doses of 35-45 mg kg(-1) of rectal paracetamol are needed to achieve sustained therapeutic plasma concentrations in healthy adult volunteers...
  6. ncbi Investigation of product quality between extemporaneously compounded progesterone vaginal suppositories and an approved progesterone vaginal gel
    Vorapann Mahaguna
    PharmaForm, LLC, Austin, TX 78758, USA
    Drug Dev Ind Pharm 30:1069-78. 2004
    ..limit testing and preservative effectiveness testing on extemporaneously compounded progesterone vaginal suppositories obtained from 10 randomly chosen compounding pharmacies (90 suppositories each) across the United States, to ..
  7. doi Sumatriptan (50 mg tablets vs. 25 mg suppositories) in the acute treatment of menstrually related migraine and oral contraceptive-induced menstrual migraine: a pilot study
    Fabio Facchinetti
    UCADH Section Psychobiology of Reproduction, Mother Infant Dept, Univ of Modena and Reggio Emilia, Emilia, Modena, Italy
    Gynecol Endocrinol 26:773-9. 2010
    ..In the OCMM group 55% of patients improved at 2 h with suppositories and 46% with tablets, 27% of patients were pain-free after suppositories and 18% after tablets...
  8. pmc Pre-referral rectal artesunate to prevent death and disability in severe malaria: a placebo-controlled trial
    M F Gomes
    UNICEF UNDP World Bank WHO Special Programme for Research and Training in Tropical Diseases, Geneva, Switzerland
    Lancet 373:557-66. 2009
    ..We investigated whether this intervention reduced mortality and permanent disability...
  9. doi A prospective randomized single blind trial of Fleet phosphate enema versus glycerin suppositories as preparation for flexible sigmoidoscopy
    D Underwood
    Department of Surgery, Altnagelvin Area Hospital, Glenshane Road, Londonderry BT47 6SB, Northern Ireland, UK
    Ir J Med Sci 179:113-8. 2010
    ..This study compared the efficacy and patient acceptability of two methods of bowel preparation for flexible sigmoidoscopy...
  10. ncbi A rapid micro quantification method of paracetamol in suppositories using differential scanning calorimetry
    Mohamed I Noordin
    Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Drug Dev Ind Pharm 30:925-30. 2004
    ..5-4.0 mg) from the tip, middle, and base sections of individual paracetamol suppositories, which were sampled carefully using a stainless steel scalpel...
  11. pmc Analysis of histological therapeutic effect, apoptosis rate and p53 status after combined treatment with radiation, hyperthermia and 5-fluorouracil suppositories for advanced rectal cancers
    C Sakakura
    First Department of Surgery, Kyoto Prefectural University of Medicine, Japan
    Br J Cancer 77:159-66. 1998
    ....
  12. pmc Efficacy and safety of mesalamine suppositories for treatment of ulcerative proctitis in children and adolescents
    Melvin B Heyman
    Department of Pediatrics, University of California, San Francisco, California 94143 0136, USA
    Inflamm Bowel Dis 16:1931-9. 2010
    ..We conducted an open-label trial to evaluate the clinical efficacy of a mesalamine suppository (500 mg) to treat pediatric patients with mild to moderate ulcerative proctitis...
  13. ncbi A pilot study evaluating the safety and effectiveness of Lactobacillus vaginal suppositories in patients with recurrent urinary tract infection
    Shinya Uehara
    Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata, Okayama 700 8558, Japan
    Int J Antimicrob Agents 28:S30-4. 2006
    ..clinical pilot study was performed to confirm the safety and effectiveness of Lactobacillus vaginal suppositories against the recurrence of bacterial urinary tract infection (UTI)...
  14. ncbi [A case of acute pancreatitis caused by 5-aminosalicylic acid suppositories in a patient with ulcerative colitis]
    Kook Hyun Kim
    Department of Internal Medicine, Yeungnam University College of Medicine, Nam Gu, Daegu, Korea
    Korean J Gastroenterol 50:379-83. 2007
    ..Topical formulations of 5-ASA like suppositories have been rarely reported to induce adverse reactions because of their limited absorption rate...
  15. ncbi Salbutamol sulfate suppositories: influence of formulation on physical parameters and stability
    Ehab I Taha
    Department of Pharmaceutics and Industrial Pharmacy, School of Pharmacy, Al Azhar University, Nasr City, Cairo, Egypt
    Pharm Dev Technol 8:21-30. 2003
    ..The prepared formulae with and without different concentrations of gels were tested for hardness, melting time, content uniformity, and drug release. The stability of some of the selected formulae was assessed...
  16. ncbi Rectal tissue, plasma and urine concentrations of mesalazine after single and multiple administrations of 500 mg suppositories to healthy volunteers and ulcerative proctitis patients
    G Aumais
    Algorithme Pharma Inc, Montreal, Quebec, Canada
    Aliment Pharmacol Ther 17:93-7. 2003
    ..Patients with ulcerative proctitis may have rectal mucosal properties different from healthy volunteers. This project compared the pharmacokinetics of rectally administered mesalazine in these two populations...
  17. ncbi [Clinical study on dinoprostone suppositories 0.8 mm used in cervical ripening and labor induction of women with term pregnancy of premature rupture of the membranes: a multicenter study]
    Li Ying Zou
    Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China
    Zhonghua Fu Chan Ke Za Zhi 45:492-6. 2010
    To investigate safety and efficacy of dinoprostone suppositories (0.8 mm) used in cervical ripening and labor induction in women with term premature rupture of the membranes.
  18. ncbi Mono- and biphasic plasma concentration-time curves of mesalazine from a 500 mg suppository in healthy male volunteers controlled by the time of defecation before dosing
    T B Vree
    Institute for Anaesthesiology, Academic Hospital Nijmegen Sint Radboud, Nijmegen, The Netherlands
    J Pharm Pharmacol 52:645-52. 2000
    This study was based on data from a bioequivalence study (n=24) of two different formulations of suppositories containing 500 mg mesalazine (formulation I and II), with a similar dissolution profile in phosphate buffer pH 6.8...
  19. ncbi Clinical and economic impact of using macrogol 3350 plus electrolytes in an outpatient setting compared to enemas and suppositories and manual evacuation to treat paediatric faecal impaction based on actual clinical practice in England and Wales
    Julian F Guest
    CATALYST Health Economics Consultants, Northwood, Middlesex, UK
    Curr Med Res Opin 23:2213-25. 2007
    ..and economic impact of using macrogol 3350 plus electrolytes (macrogol 3350; Movicol; Movicol Paediatric Plain) in an outpatient setting compared to enemas and suppositories and manual evacuation to treat paediatric faecal impaction.
  20. ncbi Effect of drug solubility on in vitro availability rate from suppositories with polyethylene glycol excipients
    N Realdon
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Padua, Italy
    Pharmazie 56:163-7. 2001
    Factors involved in the availability mechanism of different drugs from suppositories with polyethylene glycol (PEG) excipients were studied using an in vitro model of the rectal compartment with a porous membrane simulating the rectal ..
  21. doi Ulcerative proctitis: a review of pharmacotherapy and management
    Peter Laszlo Lakatos
    Semmelweis University, First Department of Medicine, H1083 Budapest, Koranyi S 2A, Hungary
    Expert Opin Pharmacother 9:741-9. 2008
    ..Ulcerative proctitis (UP) is a common presentation of ulcerative colitis (UC)...
  22. ncbi Efficacy of hyoscine-N-butyl bromide (Buscopan) suppositories as a cervical spasmolytic agent in labour
    Daya Sirohiwal
    Department of Obstetrics and Gynecology, Post Graduate Institute of Medical Sciences, Haryana, India
    Aust N Z J Obstet Gynaecol 45:128-9. 2005
    To evaluate the efficacy and safety of hyoscine-N-butyl bromide (Buscopan) suppositories in the active phase of labour, i.e. once the labour is established.
  23. ncbi Validation of liquid chromatographic method for analysis of lidocaine hydrochloride, dexamethasone acetate, calcium dobesilate, buthylhydroxyanisol and degradation product hydroquinone in suppositories and ointment
    Lj Zivanovic
    Department of Pharmaceutical Chemistry and Drug Analysis, Faculty of Pharmacy, Vojvode Stepe 450, Belgrade, Serbia
    J Chromatogr A 1088:182-6. 2005
    ..determination of lidocaine hydrochloride, dexamethasone acetate (DA) and calcium dobesilate (CD) in suppositories and ointment...
  24. doi Factors influencing adherence to referral advice following pre-referral treatment with artesunate suppositories in children in rural Tanzania
    Daudi O Simba
    Department of Community Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
    Trop Med Int Health 14:775-83. 2009
    ..We investigated factors influencing caretakers' adherence to referral advice following pre-referral treatment of their children with rectal artesunate suppositories.
  25. ncbi Pharmacokinetics/Pharmacodynamics findings after repeated administration of ARTESUNATE thermostable suppositories (RECTOCAPS) in Vietnamese patients with uncomplicated malaria
    A Benakis
    Department of Pharmacology, University of Geneva, Switzerland
    Eur J Drug Metab Pharmacokinet 31:41-5. 2006
    ..Repeated administration of ART can extend the duration of therapeutic plasma levels of the drug...
  26. ncbi Caregivers' acceptance of using artesunate suppositories for treating childhood malaria in Papua New Guinea
    Rachael L Hinton
    Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea
    Am J Trop Med Hyg 76:634-40. 2007
    Community-based interventions using artemisinin-derived suppositories may potentially reduce malaria-related childhood mortality...
  27. ncbi Efficacy of rectal artesunate compared with parenteral quinine in initial treatment of moderately severe malaria in African children and adults: a randomised study
    K I Barnes
    Division of Pharmacology, University of Cape Town, South Africa
    Lancet 363:1598-605. 2004
    ..We aimed to assess the reliability of absorption, antimalarial efficacy, and tolerability of a single rectal dose of artesunate in the initial management of moderately severe falciparum malaria...
  28. ncbi Reduction of postoperative nausea and vomiting by dimenhydrinate suppositories after strabismus surgery in children
    I D Welters
    Department of Anesthesiology and Strabismology and Neuroophthalmology, University of Giessen, Germany
    Anesth Analg 90:311-4. 2000
    ..Preanesthetic medication with midazolam (0.5 mg/kg) as well as application of either dimenhydrinate suppositories or a placebo preparation was performed 30 min before the induction of anesthesia...
  29. pmc Population pharmacokinetics of artesunate and dihydroartemisinin following intra-rectal dosing of artesunate in malaria patients
    Julie A Simpson
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Melbourne, Australia
    PLoS Med 3:e444. 2006
    ..We studied the population pharmacokinetics of intra-rectal artesunate and the relationship with parasitological responses in patients with moderately severe falciparum malaria...
  30. ncbi A randomized comparison of side effects and patient convenience between Cyclogest suppositories and Endometrin tablets used for luteal phase support in IVF treatment
    Ernest Hung Yu Ng
    Department of Obstetrics and Gynaecology, The University of Hong Kong, 6 F, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong Special Administrative Region, People s Republic of China
    Eur J Obstet Gynecol Reprod Biol 131:182-8. 2007
    This study compared side effects and patient convenience of vaginal progesterone suppositories (Cyclogest) and vaginal progesterone tablets (Endometrin) used for luteal phase support in in vitro fertilization/embryo transfer (IVF/ET) ..
  31. ncbi Pharmacokinetics and pharmacodynamics of human chorionic gonadotropin (hCG) after rectal administration of hollow-type suppositories containing hCG
    Kouji Kowari
    Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University, Machida, Tokyo, Japan
    Biol Pharm Bull 25:678-81. 2002
    ..4 +/- 0.9ng/ml) observed before the administration. These results suggest that the hollow-type suppository as a rectal delivery system of hCG is promising as a new mode of hCG therapy...
  32. ncbi A phase III randomized, placebo-controlled, double-blind study of misoprostol rectal suppositories to prevent acute radiation proctitis in patients with prostate cancer
    Andrea Hille
    Department of Radiotherapy and Radiooncology, University of Goettingen, Goettingen, Germany
    Int J Radiat Oncol Biol Phys 63:1488-93. 2005
    ....
  33. pmc Disposition of artesunate and dihydroartemisinin after administration of artesunate suppositories in children from Papua New Guinea with uncomplicated malaria
    Harin A Karunajeewa
    School of Medicine and Pharmacology, University of Western Australia, Crawley, Australia
    Antimicrob Agents Chemother 48:2966-72. 2004
    ..children from Papua New Guinea with uncomplicated falciparum or vivax malaria treated with artesunate (ARTS) suppositories (Rectocaps) given in two doses of approximately 13 mg/kg of body weight 12 h apart...
  34. ncbi Prevalence of Candida glabrata and its response to boric acid vaginal suppositories in comparison with oral fluconazole in patients with diabetes and vulvovaginal candidiasis
    Debarti Ray
    Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi 110029, India
    Diabetes Care 30:312-7. 2007
    ..tropicalis. Observational studies indicate that diabetic patients with C. glabrata VVC respond poorly to azole drugs. We evaluated the response to oral fluconazole and boric acid vaginal suppositories in diabetic patients with VVC.
  35. pmc Artesunate suppositories versus intramuscular artemether for treatment of severe malaria in children in Papua New Guinea
    Harin A Karunajeewa
    Medicine Unit Fremantle, School of Medicine and Pharmacology, University of Western Australia, Crawley
    Antimicrob Agents Chemother 50:968-74. 2006
    Drug treatment of severe malaria must be rapidly effective. Suppositories may be valuable for childhood malaria when circumstances prevent oral or parenteral therapy...
  36. ncbi Effects of surfactant characteristics on drug availability from suppositories
    N Realdon
    Department of Pharmaceutical Sciences, University of Padova, Italy
    Pharmazie 63:459-63. 2008
    ..The relationship between the melted suppositories and a membrane simulating the rectal barrier were investigated in the course of the in vitro release test by ..
  37. ncbi PVC membrane sensor for diclofenac: applications in pharmaceutical analysis and drug binding studies
    R Maleki
    Food and Chemical Analysis Research Lab, Jahad e Daneshgahi, Urmia
    Pharmazie 62:672-7. 2007
    ..The results of diclofenac assay with the proposed sensor were in good agreement with the official HPLC method...
  38. ncbi The preparation and evaluation of sustained release suppositories containing ketoprofen and Eudragit RL 100 by using factorial design
    I Ozguney
    Department of Pharmaceutical Technology, Faculty of Pharmacy, Ege University, Bornova, Izmir, Turkey
    Pharm Dev Technol 12:97-107. 2007
    The preparation of ketoprofen (KP) sustained release (SR) suppositories was designed according to the 3(2) x 2(1) factorial design as three different KP:Eudragit RL 100 ratios (1:0...
  39. pmc Diclofenac suppositories and acute ischaemic proctitis
    N Arya
    Department of Surgery, Mid Ulster Hospital, Magherafelt, Co Londonderry BT45 5EX
    Ulster Med J 73:63-4. 2004
  40. ncbi A prospective study to assess the efficacy and patient tolerance of three bowel preparations for colonoscopy
    Roderick Rapier
    Southern California Kaiser Permanente Medical Center, Division of Gastroenterology, San Diego, California, USA
    Gastroenterol Nurs 29:305-8. 2006
    ..This study suggests that a low-residue diet kit, given in conjunction with polyethylene glycol electrolyte or magnesium citrate and bisacodyl, produces adequate colon cleansing and patient tolerability...
  41. ncbi Poloxamer 188 and propylene glycol-based rectal suppository enhances anticancer effect of 5-fluorouracil in mice
    Seung Hwan Paek
    College of Pharmacy, Yeungnam University, Gyeongsan, Korea
    Biol Pharm Bull 29:1060-3. 2006
    ..Taken together, the results suggest that a poloxamer gel system with 5-FU/P188/PG is an effective rectal dosage form for the treatment of both rectal and non-rectal cancers...
  42. ncbi [Trans mucosal insulin delivery]
    Y Yamasaki
    Department of Internal Medicine and Therapeutics, Osaka University, Graduate School of Medicine
    Nippon Rinsho 59:2134-9. 2001
    ..After administration of these insulin, insulin was absorbed as rapid as intra-muscular injection of insulin and thus could effectively control postprandial glycemic excursion in diabetic patients...
  43. ncbi Rectal administration of propylthiouracil in suppository form in patients with thyrotoxicosis and critical illness: case report and review of literature
    Susan B Zweig
    Department of Medicine, Division of Endocrinology and Metabolism, Beth Israel Medical Center, University Hospital and Manhattan Campus for the Albert Einstein College of Medicine, New York, New York 10003, USA
    Endocr Pract 12:43-7. 2006
    ..To report the successful management of thyrotoxicosis in a seriously ill 47-year-old man with a perforated gastric ulcer in whom oral intake was contraindicated...
  44. ncbi Advances in anticholinergic therapy delivery systems
    G Willy Davila
    Geriatrics 57:29-34. 2002
  45. ncbi In vitro and in vivo study in rats of rectal suppositories containing furosemide
    Szilvia Berkó
    Department of Pharmaceutical Technology, University of Szeged, Hungary
    Eur J Pharm Biopharm 53:311-5. 2002
    The aim of our experimental work was to formulate furosemide-containing rectal suppositories, to study drug release with in vitro membrane diffusion examinations and to increase drug liberation with the use of non-ionic surfactants (..
  46. ncbi Rectal hydrocortisone during vomiting in children with adrenal insufficiency
    M Ni Chroinin
    Diabetes and Endocrine Centre, Our Lady s Hospital for Sick Children, Crumlin, Dublin, Ireland
    J Pediatr Endocrinol Metab 16:1101-4. 2003
    ..To evaluate rectal hydrocortisone as an emergency glucocorticoid replacement therapy in adrenal insufficient children...
  47. ncbi [Evaluation of the efficacy of wiferon and arbidol in adult influenza]
    L V Kolobukhina
    Vopr Virusol 53:31-3. 2008
    ..Within the first 24-36 hours after the onset of the disease, wiferon and arbidol reduced the duration of fever, intoxication, and the catarrhal symptoms of the disease as a whole. The agents were shown to have an immunomodulating effect...
  48. ncbi Progressive protocol in the bowel management of spinal cord injuries
    Maureen Coggrave
    National Spinal Injuries Centre, Stoke Mandeville Hospital
    Br J Nurs 15:1108-13. 2006
    ..The variable response of individuals to the progressive protocol highlights the need for individual assessment in the area of bowel. The findings of this small study must be validated by a larger study...
  49. ncbi [Combined use of intrathecal morphine and diclofenac suppository for postoperative analgesia after caesarean section]
    Ikuhiro Hidaka
    Department of Anesthesia, Matsue Red Cross Hospital, Matsue 690 8506
    Masui 52:1056-61. 2003
    ..Intrathecal morphine for postoperative analgesia after caesarean section has been used in Europe and North America, but its use is not common in Japan...
  50. ncbi Analgesic efficacy of caudal block versus diclofenac suppository and local anesthetic infiltration following pediatric laparoscopy
    Jyoti Borkar
    Department of Anesthesiology, B Y L Nair Hospital and T N Medical College, Mumbai, India
    J Laparoendosc Adv Surg Tech A 15:415-8. 2005
    ..To compare the analgesic efficacy of caudal block with diclofenac suppository and local anesthetic infiltration in children undergoing laparoscopy...
  51. ncbi A prospective, randomised trial of preoperative rectal diclofenac: are we closing the gate after the horse has gone?
    J B Lyons
    Department of Anaesthesia, Waterford Regional Hospital, Dublin Ireland
    Ir J Med Sci 172:112-4. 2003
    ..It is common clinical practice to administer a diclofenac suppository at induction to contribute to pre-emptive analgesia (PEA). Diclofenac takes up to 30 minutes to attain maximal plasma level after rectal administration...
  52. ncbi [Ulcerative colitis. Maintenance therapy]
    W Kruis
    Abt Innere Medizin, Evangelisches Krankenhaus Köln Kalk
    Z Gastroenterol 42:1011-4. 2004
  53. ncbi Opioid-sparing effects of diclofenac and paracetamol lead to improved outcomes after cardiac surgery
    Mohammed K Fayaz
    Department of Anaesthesia, University Hospital of Wales, Cardiff, United Kingdom
    J Cardiothorac Vasc Anesth 18:742-7. 2004
    This study assessed the analgesic efficacy, side effects, time to extubation, and oxygenation of 3 analgesic regimens after coronary artery bypass surgery using diclofenac, paracetamol, and placebo suppositories.
  54. ncbi Relieving perineal pain after perineorrhaphy by diclofenac rectal suppositories: a randomized double-blinded placebo controlled trial
    Vuthinun Achariyapota
    Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Med Assoc Thai 91:799-804. 2008
    ..Analgesic rectal suppository is one of various methods in pain relief especially in drowsy patients, or when oral preparation causes gastric discomfort, nausea or vomiting...
  55. ncbi Feasibility of the Ph.Eur. flow-through cell for dissolution testing of the compounded rectal suppositories containing indomethacin or sodium diclofenac
    Brunon Woyczikowski
    Department of Pharmaceutical Technology, Medical University of Gdansk, 107 Hallera Str, 80 416 Gdansk, Poland
    Acta Pol Pharm 60:169-72. 2003
    Ph.Eur. and BP have introduced a dissolution apparatus for suppositories. Suitability of the apparatus for quality control of indomethacin or sodium diclofenac (100 mg) compounded suppositories was evaluated and the effect of the type of ..
  56. ncbi Physicochemical characterization of diclofenac sodium-loaded poloxamer gel as a rectal delivery system with fast absorption
    Chul Soon Yong
    College of Pharmacy, Yeungnam University, Dae Dong, Gyongsan, Korea
    Drug Dev Ind Pharm 29:545-53. 2003
    ..Our results suggested that a rectal poloxamer gel system with sodium chloride and poloxamers was a more physically stable, convenient, and effective rectal dosage form for diclofenac sodium...
  57. ncbi Physicochemical characterization and in vivo evaluation of poloxamer-based solid suppository containing diclofenac sodium in rats
    Chul Soon Yong
    College of Pharmacy, Yeungnam University, 214 1, Dae Dong, Gyongsan 712 749, South Korea
    Int J Pharm 301:54-61. 2005
    ..Thus, the poloxamer-based solid suppository with P 124 and P 188 was a mucoadhesive, safe and effective rectal dosage form for diclofenac sodium...
  58. ncbi Reciprocating dialysis tube method: periodic tapping improved in vitro release/dissolution testing of suppositories
    Soichi Itoh
    Graduate School of Pharmaceutical Sciences, Osaka University, Japan
    Eur J Pharm Biopharm 64:393-8. 2006
    The reciprocating dialysis tube (RDT) method can be used for in vitro release/dissolution testing of suppositories and has been reported to show good in vitro and in vivo correlation...
  59. ncbi Diclofenac and metabolite pharmacokinetics in children
    Caroline D van der Marel
    Department of Paediatric Surgery, ErasmusMC Sophia Rotterdam, The Netherlands
    Paediatr Anaesth 14:443-51. 2004
    ..There are no data examining diclofenac or its hydroxyl metabolite pharmacokinetics after rectal administration in children...
  60. ncbi Evaluation of mucin as a release enhancer for rectal delivery of glibenclamide
    M U Adikwu
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka 410001, Nigeria
    Curr Drug Deliv 3:243-54. 2006
    ..Glycerogelatin suppositories containing different ratios of glibenclamide to I-mucin (insoluble), S-mucin (soluble) and sodium salicylate ..
  61. ncbi Comparison of oral versus rectal administration of acetaminophen with codeine in postoperative pediatric adenotonsillectomy patients
    Vicki Owczarzak
    Department of OTO HNS at Columbia, New York Presbyterian Hospital, 180 Fort Washington Avenue, New York, NY 10032, USA
    Laryngoscope 116:1485-8. 2006
    ..To examine whether acetaminophen with codeine administered per rectum is an effective alternative for pain control compared with oral administration after an adenotonsillectomy...
  62. ncbi Randomized, double-blind, placebo-controlled study of the effect of rectal paracetamol on morphine consumption after abdominal hysterectomy
    O Kvalsvik
    Department of Anesthesiology and Intensive Care, St Olav University Hospital, Trondheim, Norway
    Acta Anaesthesiol Scand 47:451-6. 2003
    ..Paracetamol is widely used for postoperative analgesia. The effect is well documented in minor and moderate extensive surgery, but the effect of paracetamol as an adjunct to opioids in major abdominal surgery is less examined...
  63. ncbi Acetaminophen decreases early post-thoracotomy ipsilateral shoulder pain in patients with thoracic epidural analgesia: a double-blind placebo-controlled study
    Thien Bich Mac
    Department of Anesthesiology, CHUM, Hopital Notre Dame, 1560 Sherbrooke East, Montreal, Quebec H2L 4M1, Canada
    J Cardiothorac Vasc Anesth 19:475-8. 2005
    ..This study assessed the efficacy of acetaminophen in decreasing postoperative shoulder pain after a thoracotomy...
  64. ncbi Enhanced rectal bioavailability of ibuprofen in rats by poloxamer 188 and menthol
    Chul Soon Yong
    College of Pharmacy, Yeungnam University, 214 1 Dae Dong, Gyongsan 712 749, South Korea
    Int J Pharm 269:169-76. 2004
    ..Thus, the poloxamer gel with poloxamer 188 and menthol was a more effective rectal dosage form for ibuprofen...
  65. ncbi Role of diclofenac in reducing post-endoscopic retrograde cholangiopancreatography pancreatitis
    Manouchehr Khoshbaten
    Drug Applied Research Center, Research and Development Complex, Tabriz, Iran
    J Gastroenterol Hepatol 23:e11-6. 2008
    ..We report a prospective, single-center, randomized, double-blind controlled trial to determine if rectal diclofenac reduces the incidence of pancreatitis following cholangiopancreatography...
  66. ncbi Optimization of suppository preparation containing sodium laurate and taurine that can safely improve rectal absorption of rebamipide
    Masateru Miyake
    Formulation Development 1, Formulation Research Institute, Otsuka Pharmaceutical Co Ltd, 224 18 Ebino, Hiraishi, Kawauchi cho, Tokushima 771 0182, Japan
    Biol Pharm Bull 29:330-5. 2006
    ..In the preset study, in order to make C12-Tau suppositories available for practical use, the scaling-up studies of animal and formulation size were performed, compared ..
  67. ncbi Perioperative pharmacokinetics of ibuprofen enantiomers after rectal administration
    Matti Kyllönen
    Department of Anesthesia and Intensive Care, Oulu University Hospital, Oulu, Finland
    Paediatr Anaesth 15:566-73. 2005
    ..Pharmacokinetics of rectal ibuprofen has not been studied, although suppositories are frequently used for perioperative pain control in children.
  68. ncbi [Enteral versus parenteral administration of a single dose of profenid after gynecological laparoscopy]
    V Tablov
    Akush Ginekol (Sofiia) 44:19-22. 2005
    ..As a result of our study we consider that postoperative analgesia with Profenid applied intravenously or by suppository is effective enough method for postoperative analgesia after laparoscopy in gynecology...
  69. ncbi Physicochemical characterization and in vivo evaluation of thermosensitive diclofenac liquid suppository
    Chul Soon Yong
    College of Pharmacy, Yeungnam University, 214 1, Dae Dong, Gyongsan 712 749, Korea
    Arch Pharm Res 26:162-7. 2003
    ..The liquid suppositories with less than 1...
  70. ncbi Thermally reversible in situ gelling carbamazepine liquid suppository
    Amal El-Kamel
    Department of Pharmaceutics, Faculty of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia
    Drug Deliv 13:143-8. 2006
    ..Conventional suppositories can cause patient discomfort and may reach the end of the colon; consequently, the drug can undergo the first-..
  71. ncbi Population pharmacokinetic investigation of phenobarbital by mixed effect modelling using routine clinical pharmacokinetic data in Japanese neonates and infants
    E Yukawa
    Laboratory of Evidence based Pharmacotherapy, College of Pharmaceutical Sciences, Daiichi University, Fukuoka, Japan
    J Clin Pharm Ther 30:159-63. 2005
    ....
  72. ncbi Comparison of oral versus normal and high-dose rectal acetaminophen in the treatment of febrile children
    Dennis Scolnik
    Division of Emergency Services, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatrics 110:553-6. 2002
    ..To compare the defervescent effect of high-dose rectal suppository acetaminophen with the recommended oral and rectal dosages and to evaluate acceptability of rectal acetaminophen...
  73. ncbi Acetaminophen dosing for neonates, infants, and children
    Charmaine Kleiber
    College of Nursing, University of Iowa Iowa City, IA, USA
    J Spec Pediatr Nurs 13:48-9. 2008
  74. ncbi Bioequivalence of progesterone sustained release suppository in rabbits
    Lihong Long
    Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    J Huazhong Univ Sci Technolog Med Sci 25:470-2. 2005
    ..The relative bioavailability of T to R were (104.2 +/- 13.4)% and (111.4 +/- 19.1)%, respectively. Statistical analysis showed that the two formulations were bioequivalent and T had sustained released feature...
  75. ncbi Increased bioavailability of tacrolimus after rectal administration in rats
    Masayuki Sakai
    Department of Hospital Pharmacy, Faculty of Medicine, University of the Ryukyus, 207 Aza Uehara, Nishihara cho, Nakagami gun, Okinawa 903 0215, Japan
    Biol Pharm Bull 27:1480-2. 2004
    ..These results clearly suggest a possibility that rectal administration of tacrolimus is capable of improving its bioavailability and cutting the costs of tacrolimus treatment...
  76. ncbi Evaluation of snail mucin motifs as rectal absorption enhancer for insulin in non-diabetic rat models
    Michael Umale Adikwu
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria
    Biol Pharm Bull 28:1801-4. 2005
    ..The % basal blood glucose level of the rats that received the batch of suppositories containing no mucin were consistently above 100% except at the ninetieth minute when it came down slightly to ..
  77. ncbi Rectal administration of propylthiouracil in hyperthyroid patients: comparison of suspension enema and suppository form
    W Jongjaroenprasert
    Division of Endocrinology and Metabolism, Department of Medicine, Ramathidodi Hospital, Mahidol University, Bangkok, Thailand
    Thyroid 12:627-31. 2002
    ..described the therapeutic effects of propylthiouracil (PTU) and methimazole in normal subjects after rectal suppositories. The goal of our study was to compare the pharmacokinetic and pharmacologic effects of a suppository and ..
  78. ncbi Life-saving rectal artesunate for complicated malaria in children
    Krisana Pengsaa
    Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, 420 6 Ratchawithi Rd, Bangkok 10400, Thailand
    Southeast Asian J Trop Med Public Health 36:597-601. 2005
    ..Further studies for the optimized regimen of rectal artesunate in the treatment of cerebral/complicated childhood falciparum malaria in areas of multidrug resistance are warranted...
  79. pmc Rectal artemether versus intravenous quinine for the treatment of cerebral malaria in children in Uganda: randomised clinical trial
    Jane Ruth Aceng
    Department of Paediatrics and Child Health, Makerere Medical School, PO Box 7072, Kampala, Uganda
    BMJ 330:334. 2005
    ..To compare the efficacy and safety of rectal artemether with intravenous quinine in the treatment of cerebral malaria in children...
  80. ncbi Pharmacokinetics of theophylline after administration of suppositories formulation
    L I Abou-Basha
    Drug Bioavailability Center, National Organization for Drug Control and Research NODCAR, Cairo, Egypt
    J Immunoassay Immunochem 26:251-8. 2005
    ..were evaluated in 24 healthy male subjects after administration of theophylline ethanoate of piperazine suppositories (PR) (Minophylline 500 mg. Alexandria Co...
  81. pmc A qualitative study to identify community structures for management of severe malaria: a basis for introducing rectal artesunate in the under five years children in Nakonde District of Zambia
    Frederick A D Kaona
    Department of Behavioural Sciences, Mwengu Social and Health Research Centre, 12 Kafupi Road, Plot Number 1410 130 Northrise, P O Box 73693, Ndola, Zambia
    BMC Public Health 5:28. 2005
    ....
  82. pmc Treating severe malaria
    Christopher J M Whitty
    BMJ 330:317-8. 2005
  83. pmc Pain management during uterine artery embolization for symptomatic uterine fibroids
    L E Lampmann
    Cardiovasc Intervent Radiol 30:809-11. 2007
  84. ncbi Prospective randomized trial of pre-emptive analgesics following ambulatory inguinal hernia repair: intravenous ketorolac versus diclofenac suppository
    Hung Lau
    Department of Surgery, Tung Wah Hospital, University of Hong Kong Medical Centre, Sheung Wan, Hong Kong
    ANZ J Surg 72:704-7. 2002
    ..The present prospective randomized trial was undertaken to compare the efficacy of intravenous ketorolac and rectal diclofenac for ambulatory inguinal hernia repairs...
  85. ncbi Bioavailability of metronidazole in rabbits after administration of a rectal suppository
    Sabinus I Ofoefule
    Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria
    Am J Ther 11:190-3. 2004
    ..The in vitro dissolution profile of the suppositories further confirms rapid absorption of the drug from the suppositories in the rectum...
  86. ncbi [Induced termination of second and third trimester pregnancy in women with scarred uterus]
    Li Ying Zou
    Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China
    Zhonghua Fu Chan Ke Za Zhi 45:17-21. 2010
    ..To investigate the suitable mode of induced termination of pregnancy at second and third trimester for women with scarred uterus...
  87. ncbi Analysis of pharmaceutical preparations containing antihistamine drugs by micellar liquid chromatography
    C Martínez-Algaba
    Departamento de Quimica Analitica, Universitat de Valencia, C Vicente Andrés Estellés s n, E 46100 Burjassot, Valencia, Spain
    J Pharm Biomed Anal 40:312-21. 2006
    ..guaifenesin, paracetamol and pyridoxine in different pharmaceutical presentations (tablets, capsules, suppositories, syrups and ointments)...
  88. ncbi Acute renal failure associated with an accidental overdose of colchicine
    J Borras-Blasco
    Pharmacy Service, Hospital General Universitario de Elche, Spain
    Int J Clin Pharmacol Ther 43:480-4. 2005
    ..o. over a period of 4 - 5 hours together with six suppositories each containing 100 mg of indomethacin...
  89. ncbi Clinical pharmacology of tramadol
    Stefan Grond
    Department of Anesthesia, Martin Luther University, Halle Wittenberg, Germany
    Clin Pharmacokinet 43:879-923. 2004
    ..Tramadol is available as drops, capsules and sustained-release formulations for oral use, suppositories for rectal use and solution for intramuscular, intravenous and subcutaneous injection...
  90. ncbi Treatment of childhood constipation by primary care physicians: efficacy and predictors of outcome
    Stephen M Borowitz
    Department of Pediatrics, University of Virginia, Charlottesville, Virginia 22908, USA
    Pediatrics 115:873-7. 2005
    ..With this study, we prospectively examined which treatments primary care physicians prescribe to children who present for the first time with constipation and how effective those treatments are...
  91. ncbi Proctoscopy should be mandatory in men that have sex with men with external anogenital warts
    Bostjan Mlakar
    RoZna Dolina Surgical Centre, Department for Abdominal Surgery and Proctology, RoZna dolina cesta IV 45, 1000 Ljubljana, Slovenia
    Acta Dermatovenerol Alp Panonica Adriat 18:7-11. 2009
    ..The aim of this study was to evaluate anal pathology in men having sex with men (MSM) seen at our proctology outpatient clinics...
  92. ncbi Development of a mucoadhesive dosage form for vaginal administration
    G C Ceschel
    Department of Pharmaceutical Science, University of Bologna, Italy
    Drug Dev Ind Pharm 27:541-7. 2001
    ..from a modification of the Satnikar and Fantelli method for the evaluation of the liquefaction time of rectal suppositories. This test simulates the physiological vaginal condition and verifies the efficiency of the polymers in ..
  93. ncbi Efficacy of povidone-iodine vaginal suppositories in the treatment of bacterial vaginosis
    Günther Wewalka
    Federal Public Health Laboratory, Vienna, Austria
    Dermatology 204:79-85. 2002
    A prospective, randomized clinical trial was performed to study the efficacy of povidone iodine (Betadine) suppositories for the treatment of bacterial vaginosis (BV) in comparison to capsules containing lactobacilli (Döderlein Med)...
  94. ncbi Modified continuous femoral three-in-one block for postoperative pain after total knee arthroplasty
    S Ganapathy
    Department of Anesthesia, London Health Sciences Center, University of Western Ontario, Canada
    Anesth Analg 89:1197-202. 1999
    ..All patients received patient-controlled analgesia with morphine and indomethacin suppositories for 48 h. Using computed tomography, we evaluated the catheter location for 20 patients...
  95. doi Efficacy and safety of vaginal estriol and progesterone in postmenopausal women with atrophic vaginitis
    Janet A Chollet
    Beth Israel Deaconess Medical Center, Boston, MA, USA
    Menopause 16:978-83. 2009
    ..The aim of this study was to assess the efficacy and safety of intravaginal estriol and progesterone on atrophic vaginitis in postmenopausal women...
  96. ncbi Successful delivery after vaginal radical trachelectomy for invasive uterine cervical cancer
    Shin ichi Ishioka
    Department of Obstetrics and Gynecology, Sapporo Medical University, School of Medicine, Minami 1 jo, Nishi 17 chome, Sapporo, Hokkaido 060 8543, Japan
    Int J Clin Oncol 11:146-9. 2006
    ..Both the mother and the baby were discharged without trouble. This is the first successful case in Japan of delivery after vaginal RT for invasive uterine cervical cancer...
  97. doi A randomized controlled trial of pudendal nerve block for pain relief after episiotomy
    Younès Aissaoui
    Département d Anesthésie Réanimation et Urgences, Hôpital Militaire d Instruction des Armées Mohammed V Rabat, Rabat, Morocco
    Anesth Analg 107:625-9. 2008
    ..We performed this randomized, double-blind, controlled trial to investigate the efficacy of nerve stimulator-guided unilateral pudendal nerve block for pain relief after episiotomy...
  98. ncbi Increased urinary nitrite excretion in primary enuresis: effects of indomethacin treatment on urinary and serum osmolality and electrolytes, urinary volumes and nitrite excretion
    N S Al-Waili
    Dubai Specialized Medical Center and Medical Research Laboratories, Islamic Establishment for Education, Dubai, United Arab Emirates
    BJU Int 90:294-301. 2002
    ....
  99. ncbi Luteal phase hormonal profile in prediction of pregnancy outcome after assisted reproduction
    K Vicdan
    Assisted Reproductive Technologies Center, Bayindir Hospital, Menevis Sokak 30 6, 06540 A Ayranci, Ankara, Turkey
    Eur J Obstet Gynecol Reprod Biol 96:98-101. 2001
    ..All the patients had luteal support with vaginal progesterone suppositories after embryo transfer (ET)...
  100. ncbi Newer formulations of the triptans: advances in migraine management
    Jonathan Paul Gladstone
    Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Drugs 63:2285-305. 2003
    ..newer routes of administration, including orally disintegrating tablets (rizatriptan and zolmitriptan), rectal suppositories (sumatriptan) and intranasal sprays (sumatriptan and zolmitriptan)...
  101. ncbi Acetaminophen developmental pharmacokinetics in premature neonates and infants: a pooled population analysis
    Brian J Anderson
    Auckland Children s Hospital, Auckland, New Zealand
    Anesthesiology 96:1336-45. 2002
    ..The aim of this study was to describe acetaminophen developmental pharmacokinetics in premature neonates through infancy to suggest age-appropriate dosing regimens...

Research Grants86

  1. Mechanisms of tumor suppressor gene reactivation in colon cancer by berries
    Li Shu Wang; Fiscal Year: 2010
    ..treatment of FAP patients with BRB powder administered both orally (20g/3x/day) and in the form of rectal suppositories caused a 53% regression rate of rectal polyps...
  2. INDOMETHACIN FOR ADJUVANT TOCOLYSIS
    George Macones; Fiscal Year: 2004
    ..Patients will be randomized to receive either indomethacin rectal suppositories (50 mg every 6 hours) or identical-appearing placebo suppositories for a maximum of 48 hours...
  3. TREATMENT EVALUATION IN PREMENSTRUAL SYNDROME PATIENTS
    Ellen Freeman; Fiscal Year: 1992
    ....
  4. MISOPROSTOL FOR TREATMENT OF FETAL DEATH AT 14-28 WEEKS PHASE III
    Beverly Winikoff; Fiscal Year: 2007
    ..and evacuation surgery, administration of intravenous oxytocin, and administration of prostaglandin E2 suppositories. In recent years, however, most physicians appear to have adopted the practice of administering misoprostol, a ..
  5. INDOMETHACIN FOR ADJUVANT TOCOLYSIS
    George Macones; Fiscal Year: 2005
    ..Patients will be randomized to receive either indomethacin rectal suppositories (50mg every 6 hours) or identical appearing placebo suppositories for 48 hours...
  6. ACCEPTABILITY OF SPERMICIDES ACROSS RISK GROUPS AND TIME
    Helen Koo; Fiscal Year: 2003
    ..aims: To increase understanding of the factors affecting choice and use of methods, including vaginal gels and suppositories and condoms, to protect against STDs and HIV/AIDS; To develop better measures for studying acceptability of ..
  7. IMMUNIZATION AGAINST URINARY TRACT INFECTION
    DAVID UEHLING; Fiscal Year: 2001
    ..2. Utilize an animal model to clarify the immunologic basis for the increased resistance to UTI following vaginal immunization and to evaluate adjuvants and vaccination regimes that optimize immunogenicity and efficacy of UTI vaccines. ..
  8. Use of Modified Lactobacilli to Block HIV Transmission
    CHIA HWA CHANG; Fiscal Year: 2002
    ..Importantly, the studies proposed in this application relate directly to a product concept associated with an unmet medical need and substantial commercial opportunity. ..
  9. Display of HIV Binding Proteins on Bacterial S-Layers
    David Simpson; Fiscal Year: 2002
    ..It will be convenient to use and female-controlled. Importantly, this product concept is associated with an unmet medical meed and substantial commercial opportunity. ..
  10. Enhancing HIV Medication Adherence in India
    DEBORAH LYNNE JONES; Fiscal Year: 2010
    ....
  11. Increased Access to Emergency Contraceptive Pills
    Elizabeth Raymond; Fiscal Year: 2004
    ..These secondary analyses should help explain the primary biologic outcomes and should be useful in the development of counseling messages and service protocols in the future. ..
  12. Implementing HIV Risk Reduction Zambia
    DEBORAH LYNNE JONES; Fiscal Year: 2010
    ....
  13. Interventions to Enhance HIV Medication Adherence in Zambia
    Deborah Jones; Fiscal Year: 2007
    ....
  14. Implementing HIV Risk Reduction Zambia
    Deborah Jones; Fiscal Year: 2009
    ....
  15. Zambia/US Research Partnership in HIV Prevention
    Deborah Jones; Fiscal Year: 2006
    ..Successful elements from this behavioral intervention will be offered through the RDTP Dissemination component for training and implementation in VCT programs throughout Zambia. ..
  16. Pathologic Markers of Genetic Damage and Disease in IBD
    Melvin Heyman; Fiscal Year: 2005
    ..abstract_text> ..
  17. Anti-HIV Microbicide: Cellulose Acetate Phthalate (CAP)
    A Robert Neurath; Fiscal Year: 2004
    ..The proposed research is expected to help transform this ideal into a reality. ..
  18. Genomics of Susceptibility to Urinary Tract Infections
    WALTER HOPKINS; Fiscal Year: 2007
    ..coli strains or non-E, coil bacteria. These objectives will be accomplished using a well-established mouse model of ascending UTI, genetic linkage analysis, and evaluation of resistance to uropathogens in congenic mice. ..
  19. Role of E. coli Virulence Factors in Chronic Prostate Infection and Inflammation
    WALTER HOPKINS; Fiscal Year: 2007
    ..Secondarily, we will investigate which E. coli genes play a direct or indirect role in development of prostatic lesions. Results of these studies can lead to new methods to prevent or treat chronic bacterial prostatitis. ..
  20. URINARY TRACT INFECTIONS: IMMUNE BASIS OF SUSCEPTIBILITY
    WALTER HOPKINS; Fiscal Year: 1993
    ..coli virulence factors modulate the pathogenesis of UTI in immunodeficient mice...
  21. URINARY TRACT INFECTIONS--IMMUNE BASIS OF SUSCEPTIBILITY
    WALTER HOPKINS; Fiscal Year: 2003
    ....
  22. Predictors of HIV Risk Behavior Among Men in Argentina
    Alex Carballo Dieguez; Fiscal Year: 2007
    ..This is a fundamental step prior to designing programs that mitigate those factors and result in decreased risk. ..
  23. Topical Microbicide Acceptability
    Alex Carballo Dieguez; Fiscal Year: 2006
    ..whether or not there are different attitudes about and intentions to use rectal microbicide gels as opposed to suppositories; and whether or not attitudes and intentions change from before to after the product trial...
  24. Internet Use and HIV Risk among Men in NYC
    Alex Carballo Dieguez; Fiscal Year: 2005
    ..abstract_text> ..
  25. CORE--Technology and Regulatory Core Unit
    A Robert Neurath; Fiscal Year: 2004
    ..Core Bc, in collaboration with Core Ba. Bb and Bd, will also provide analytical support. Core Bd will provide ZnFIs and analytical and regulatory support related to ZnFIs. ..