pharmaceutical solutions

Summary

Summary: Homogeneous liquid preparations that contain one or more chemical substances dissolved, i.e., molecularly dispersed, in a suitable solvent or mixture of mutually miscible solvents. For reasons of their ingredients, method of preparation, or use, they do not fall into another group of products.

Top Publications

  1. ncbi Pharmaceutical development of a parenteral lyophilised dosage form for the novel anticancer agent C1311
    Monique W J den Brok
    Slotervaart Hospital The Netherlands Cancer Institute, Department of Pharmacy and Pharmacology, Amsterdam
    PDA J Pharm Sci Technol 59:285-97. 2005
  2. ncbi Stability of norepinephrine infusions prepared in dextrose and normal saline solutions
    Maryse Tremblay
    Department of Anesthesiology, Centre Hospitalier Affilie Universitaire De Quebec, Universite Laval, Quebec City, Quebec, Canada
    Can J Anaesth 55:163-7. 2008
  3. ncbi Characterization of a potential medium for 'biorelevant' in vitro release testing of a naltrexone implant, employing a validated stability-indicating HPLC method
    Sunil S Iyer
    Department of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298 0533, USA
    J Pharm Biomed Anal 43:845-53. 2007
  4. ncbi Stability of oral liquid preparations of methylergometrine
    K Marigny
    Laboratory of Analytical Chemistry, Faculty of Pharmacy, University of Rennes, France
    Pharmazie 61:701-5. 2006
  5. ncbi Ranitidine (Zantac) syrup versus Ranitidine effervescent tablets (Zantac) EFFERdose) in children: a single-center taste preference study
    Vanessa Z Ameen
    Clinical Pharmacology and Discovery Medicine, Research and Development, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA
    Paediatr Drugs 8:265-70. 2006
  6. ncbi Acceptance of uncoated mini-tablets in young children: results from a prospective exploratory cross-over study
    Natalie Spomer
    Department of General Paediatrics and Neonatology, University Children s Hospital, Dusseldorf, Germany
    Arch Dis Child 97:283-6. 2012
  7. ncbi The dental implications of chronic use of acidic medicines in medically compromised children
    J H Nunn
    Department of Child Dental Health, School of Dentistry, Framlington Place, Newcastle upon Tyne, NE2 4BW, UK
    Pharm World Sci 23:118-9. 2001
  8. ncbi Particulate and microbial contamination in in-use admixed intravenous infusions
    Katsuhiro Yorioka
    Department of Pharmacy, Saiseikai Yamaguchi University Hospital, Japan
    Biol Pharm Bull 29:2321-3. 2006
  9. ncbi Is the use of a 200 ml vessel suitable for dissolution of low dose drug products?
    Debbie J Crail
    Procter and Gamble Pharmaceuticals, 8700 Mason Montgomery Road, Mason, OH 45040, USA
    Int J Pharm 269:203-9. 2004
  10. ncbi A stability-indicating HPLC method for medroxyprogesterone acetate in bulk drug and injection formulation
    Jankana Burana-Osot
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Silpakorn University, Sanamchandra Palace Campus, Nakhon Pathom 73000, Thailand
    J Pharm Biomed Anal 40:1068-72. 2006

Detail Information

Publications231 found, 100 shown here

  1. ncbi Pharmaceutical development of a parenteral lyophilised dosage form for the novel anticancer agent C1311
    Monique W J den Brok
    Slotervaart Hospital The Netherlands Cancer Institute, Department of Pharmacy and Pharmacology, Amsterdam
    PDA J Pharm Sci Technol 59:285-97. 2005
    ..The drug is currently used in phase I clinical trials...
  2. ncbi Stability of norepinephrine infusions prepared in dextrose and normal saline solutions
    Maryse Tremblay
    Department of Anesthesiology, Centre Hospitalier Affilie Universitaire De Quebec, Universite Laval, Quebec City, Quebec, Canada
    Can J Anaesth 55:163-7. 2008
    ..Data on long term stability of NE solutions are lacking. This prospective study was designed to evaluate the stability of NE, in dextrose (5%) in water (D5W) and in normal saline (NS) solutions, for a period up to seven days...
  3. ncbi Characterization of a potential medium for 'biorelevant' in vitro release testing of a naltrexone implant, employing a validated stability-indicating HPLC method
    Sunil S Iyer
    Department of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298 0533, USA
    J Pharm Biomed Anal 43:845-53. 2007
    ..This was applied to an investigation of in vitro drug release. The method has been proven to be suitable for investigation of naltrexone released from the implant...
  4. ncbi Stability of oral liquid preparations of methylergometrine
    K Marigny
    Laboratory of Analytical Chemistry, Faculty of Pharmacy, University of Rennes, France
    Pharmazie 61:701-5. 2006
    ..No degradation products were revealed. This study allowed an oral ready to use solution of methylergometrine (0.05 mg/ml) to be prepared, with a shelf life of more than one month (47 days) when stored at room temperature without light...
  5. ncbi Ranitidine (Zantac) syrup versus Ranitidine effervescent tablets (Zantac) EFFERdose) in children: a single-center taste preference study
    Vanessa Z Ameen
    Clinical Pharmacology and Discovery Medicine, Research and Development, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA
    Paediatr Drugs 8:265-70. 2006
    ..Ranitidine syrup is available in a peppermint-flavored 15 mg/mL formulation...
  6. ncbi Acceptance of uncoated mini-tablets in young children: results from a prospective exploratory cross-over study
    Natalie Spomer
    Department of General Paediatrics and Neonatology, University Children s Hospital, Dusseldorf, Germany
    Arch Dis Child 97:283-6. 2012
    ..To explore the acceptance of uncoated drug-free mini-tablets 2 mm in diameter in children aged 0.5-6 years and their ability to swallow the mini-tablets...
  7. ncbi The dental implications of chronic use of acidic medicines in medically compromised children
    J H Nunn
    Department of Child Dental Health, School of Dentistry, Framlington Place, Newcastle upon Tyne, NE2 4BW, UK
    Pharm World Sci 23:118-9. 2001
    ..The active agent, as well as some of the other ingredients, can pose a threat to oral health...
  8. ncbi Particulate and microbial contamination in in-use admixed intravenous infusions
    Katsuhiro Yorioka
    Department of Pharmacy, Saiseikai Yamaguchi University Hospital, Japan
    Biol Pharm Bull 29:2321-3. 2006
    ..No microbial contamination was observed in any of the residual solutions of 5 types of admixture...
  9. ncbi Is the use of a 200 ml vessel suitable for dissolution of low dose drug products?
    Debbie J Crail
    Procter and Gamble Pharmaceuticals, 8700 Mason Montgomery Road, Mason, OH 45040, USA
    Int J Pharm 269:203-9. 2004
    ..The results of the multiple dosage units per vessel also gave similar results to that of the USP monograph method...
  10. ncbi A stability-indicating HPLC method for medroxyprogesterone acetate in bulk drug and injection formulation
    Jankana Burana-Osot
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Silpakorn University, Sanamchandra Palace Campus, Nakhon Pathom 73000, Thailand
    J Pharm Biomed Anal 40:1068-72. 2006
    ..The method was found to be suitable for the quality control of MPA in bulk drug and injections as well as the stability-indicating studies...
  11. ncbi Nomenclature associated with chemical characterization of and compatibility evaluations for medical product delivery systems
    Dennis R Jenke
    Technology Resources, Baxter Healthcare Corporation, Round Lake, IL 60073, USA
    PDA J Pharm Sci Technol 57:97-108. 2003
    ..This manuscript puts forth a nomenclature which classifies those chemical entities which participate in the system/product interaction and delineates the various extraction strategies which may be used in compatibility assessments...
  12. ncbi Three simultaneous dissolution profiles on a solid pharmaceutical formulation by a FIA manifold provided with a single spectrophotometric detector
    E Vranic
    Department of Analytical Chemistry, University of Valencia, Moliner 50, 46100 Burjassot, Valencia, Spain
    J Pharm Biomed Anal 33:1039-48. 2003
    ..The analytical errors when the concentration of one drug is very small or very high are also checked...
  13. ncbi Stability of dolasetron in two oral liquid vehicles
    Cary E Johnson
    College of Pharmacy, University of Michigan, University of Michigan Hospitals and Health Centers, Ann Arbor, MI, USA
    Am J Health Syst Pharm 60:2242-4. 2003
    ..An extemporaneously compounded oral liquid preparation of dolasetron mesylate 10 mg/mL in a 1:1 mixture of Ora-Plus and strawberry syrup or Ora-Sweet was stable for at least 90 days when stored at 3-5 or 23-25 degrees C...
  14. ncbi Tuning the polymer release from hydrophilic matrix tablets by mixing short and long matrix polymers
    Anna Korner
    Department of Physical Chemistry 1, Center for Chemistry and Chemical Engineering, Lund University, Box 124, SE 221 00, Lund, Sweden
    J Pharm Sci 94:759-69. 2005
    ..The presence of small amounts of additives in the nonpurified commercial samples had no significant effect on the tablet dissolution within the uncertainty of the experiment...
  15. ncbi Long-term stabilization of recombinant human interferon alpha 2b in aqueous solution without serum albumin
    Llamil Ruiz
    Formulation Development Department, Center for Genetic Engineering and Biotechnology CIGB, P O Box 6162, Havana, Cuba
    Int J Pharm 264:57-72. 2003
    ..Furthermore, both the physical stability (color, odor, appearance, pH, and absence of particulate material) and the sterility of this formulation were maintained under the proposed shelf conditions...
  16. ncbi Challenges and opportunities in the encapsulation of liquid and semi-solid formulations into capsules for oral administration
    Ewart T Cole
    Capsugel Division of Pfizer, CH 4114 Hofstetten, Switzerland
    Adv Drug Deliv Rev 60:747-56. 2008
    ..Filling and sealing technologies for hard capsules, provides the formulator with the flexibility of developing formulations in-house from small scale, as required for Phase I studies, up to production...
  17. ncbi Timed-release formulation to avoid drug-drug interaction between diltiazem and midazolam
    Toyohiro Sawada
    DDS Research, Novel Pharmaceutical Research Laboratories, Yamanouchi Pharmaceutical Company, Ltd, 180 Ozumi, Yaizu, Shizuoka 425 0072, Japan
    J Pharm Sci 92:790-7. 2003
    ....
  18. ncbi Effects of annealing lyophilized and spray-lyophilized formulations of recombinant human interferon-gamma
    Serena D Webb
    Department of Chemical Engineering, University of Colorado, Boulder, Colorado 80309 0424, USA
    J Pharm Sci 92:715-29. 2003
    ....
  19. ncbi Physical and chemical stability of pemetrexed in infusion solutions
    Yanping Zhang
    MD Anderson Cancer Center, The University of Texas, Houston, 77030, USA
    Ann Pharmacother 40:1082-5. 2006
    ..Currently, there is no information on the long-term stability of pemetrexed beyond 24 hours...
  20. ncbi Physical and chemical stability of pemetrexed solutions in plastic syringes
    Yanping Zhang
    Pharmacy Laboratory, The University of Texas, MD Anderson Cancer Center, Houston, 77030, USA
    Ann Pharmacother 39:2026-8. 2005
    ..Currently, there is no information on the long-term stability of pemetrexed solutions beyond 24 hours...
  21. ncbi A new formulation concept for drugs with poor water solubility for parenteral application
    K Jurgens
    Department for Pharmaceutics and Biopharmaceutics, Christian Albrecht University Kiel, Germany
    Pharmazie 60:665-70. 2005
    ..First in vivo data show good tolerability and blood plasma levels which are comparable to conventional solutions...
  22. ncbi Development of parenteral formulation for a novel angiogenesis inhibitor, CKD-732 through complexation with hydroxypropyl-beta-cyclodextrin
    Jae Hyun Kim
    Pharmaceutical Research Labs, CKD Research Institute, Chong Kun Dang Pharm, P O Box 74, Chonan 330 600, South Korea
    Int J Pharm 272:79-89. 2004
    ..hemioxalate solution with the favorable reduction of irritation. These results demonstrate that the CKD-732/HP-beta-CyD complex is an attractive formulation for use in the parenteral delivery of CKD-732...
  23. ncbi Extemporaneous procedures for dissolving risedronate tablets for oral administration and for feeding tubes
    Richard J Dansereau
    Procter and Gamble Pharmaceuticals, Mason, OH 45040 9462, USA
    Ann Pharmacother 39:63-7. 2005
    ..Extemporaneous procedures for dissolving tablets for feeding tubes and for preparation of an oral liquid have not previously been evaluated...
  24. ncbi Dissolution rate enhancement by adsorption of poorly soluble drugs on hydrophilic silica aerogels
    Irina Smirnova
    Fachgebiet Thermodynamik und Thermische Verfahrenstechnik, Institut fur Verfahrenstechnik, Technische Universitat Berlin, Berlin, Germany
    Pharm Dev Technol 9:443-52. 2004
    ..The dissolution rate of poorly water soluble drugs can be significantly enhanced by adsorption on highly porous hydrophilic silica aerogels...
  25. ncbi Physicochemical characterization of ricobendazole: I. Solubility, lipophilicity, and ionization characteristics
    Zimei Wu
    School of Pharmacy, University of Otago, P O Box 913, Dunedin, New Zealand
    J Pharm Sci 94:983-93. 2005
    ....
  26. ncbi Solution stability of factor Xa inhibitors as a function of pH
    Pei Yang
    Drug Development, Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    Drug Dev Ind Pharm 30:967-73. 2004
    ..The mechanism of the reaction is not a specific-acid/base-catalyzed reaction. Based on the experience of this study, an ideal experimental design is proposed, which will be useful for future study on similar drug candidate...
  27. ncbi Stabilization of rasburicase and physico-chemical characterization of the resulting injectable formulation
    Alain Bayol
    Analytical Science Department, Sanofi Synthelabo Recherche, Labege, France
    Drug Dev Ind Pharm 30:877-89. 2004
    ..Crystallised excipients participate in forming the structure of the powder and therefore help to prevent any collapse. Amorphous mannitol creates a surrounding medium favourable to the stability of the protein...
  28. ncbi A validated stability indicating ion-pair RP-LC method for zoledronic acid
    B Mallikarjuna Rao
    Analytical Research, Custom Pharmaceutical Services, Dr Reddy s Laboratories, Hyderabad 500049, India
    J Pharm Biomed Anal 39:781-90. 2005
    ..It can be also used to test the stability samples of zoledronic acid...
  29. ncbi Determination of cetirizine dihydrochloride, related impurities and preservatives in oral solution and tablet dosage forms using HPLC
    A M Y Jaber
    Chemistry Department, King Fahid University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia
    J Pharm Biomed Anal 36:341-50. 2004
    ..28-0.86 microg ml(-1), respectively. The method proved to be specific, stability indicating, accurate, precise, robust and could be used as an alternative to the European pharmacopoeial method set for CZ and its related impurities...
  30. ncbi In vitro and in vivo evaluation of a sulfobutyl ether beta-cyclodextrin enabled etomidate formulation
    Michelle P McIntosh
    The Center for Drug Delivery Research, The University of Kansas, 2099 Constant Avenue, Lawrence, KS 66047, USA
    J Pharm Sci 93:2585-94. 2004
    ..The results suggest that the SBE-CD formulation is a viable clinical drug product with a reduced side-effect profile...
  31. ncbi An explanation for the physical instability of a marketed fixed dose combination (FDC) formulation containing isoniazid and ethambutol and proposed solutions
    Hemant Bhutani
    Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research, SAS Nagar, Punjab, India
    Drug Dev Ind Pharm 30:667-72. 2004
    ..The study suggests that barrier packaging free from defects and alternatively (or in combination) film coating of the tablets with water-resistant polymers are essential for this formulation...
  32. ncbi Preparation and characterization of enrofloxacin/carbopol complex in aqueous solution
    Myung Kwan Chun
    College of Pharmacy, Chosun University, Gwangju 501 759, Korea
    Arch Pharm Res 27:670-5. 2004
    ..Therefore, these observations suggest that Carbo-enrofloxacin complex I can be used to mask the taste of enrofloxacin...
  33. ncbi Inclusion complexation of diazepam with different cyclodextrins in formulations for parenteral use
    C Holvoet
    Department of Pharmaceutical Technology and Physical Pharmacy, Vrije Universiteit Brussel VUB Brussels, Belgium
    Pharmazie 60:598-603. 2005
    ..The stability of the preparations, with and without pH adjustment to pH 5, was investigated during 18 months and during this period no noticeable degradation was observed...
  34. ncbi Stability of Ala 125 recombinant human interleukin-2 in solution
    Nuria Reyes
    Center for Genetic Engineering and Biotechnology, P O Box 6162, Havana, Cuba
    J Pharm Pharmacol 57:31-7. 2005
    ..Taken together, these preformulation results can be used to design an adequate liquid vehicle for rhIL-2A(125) to be manufactured for human use...
  35. ncbi Compatibility of palonosetron with cyclophosphamide and with ifosfamide during simulated Y-site administration
    Quanyun A Xu
    Division of Pharmacy, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Am J Health Syst Pharm 62:1998-2000. 2005
    ..The physical and chemical compatibility of palonosetron with cyclophosphamide and with ifosfamide during simulated Y-site administration was studied...
  36. ncbi Study of insolubility problems of dexamethasone and digoxin: cyclodextrin complexation
    V Dilova
    Department of Galenical, Chemical Pharmaceutical Research Institute, Sofia, Bulgaria
    Boll Chim Farm 143:20-3. 2004
    ..The same results can be achieved through HP beta CD, by including Dex in a multicomponent composition containing HP beta CD and citric acid in a molar ratio of 1:4:1...
  37. ncbi Physical and chemical stability of palonosetron hydrochloride with five common parenteral drugs during simulated Y-site administration
    Thomas C Kupie
    Analytical Research Laboratories, Oklahoma City, OK, USA
    Am J Health Syst Pharm 65:1735-59. 2008
    ..The physical and chemical compatibility of palonosetron hydrochloride with atropine sulfate, famotidine, heparin sodium, lidocaine hydrochloride, and potassium chloride during simulated Y-site administration were studied...
  38. ncbi Stability of flucytosine 50 mg/mL in extemporaneous oral liquid formulations
    Heather L Vandenbussche
    University of Michigan Hospitals and Health Centers UMHHC, Ann Arbor, USA
    Am J Health Syst Pharm 59:1853-5. 2002
  39. ncbi Solution-mediated phase transformation of anhydrous to dihydrate carbamazepine and the effect of lattice disorder
    D Murphy
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor 48109 1065, USA
    Int J Pharm 246:121-34. 2002
    ..These results have significant consequences on the concentration-time profiles of active pharmaceutical ingredients during dissolution of metastable solid phases, crystalline or amorphous...
  40. ncbi Failure of stability prediction for minodronic acid injectable by accelerated stability testing
    Katsutoshi Nakamura
    Pharmaceutical Technology Laboratories and Novel Pharmaceutical Laboratories, Institute for Drug Development and Research, Yamanouchi Pharmaceutical Co, Ltd, 180 Ozumi Yaizu shi, 425 0072, Shizuoka ken, Japan
    Int J Pharm 241:65-71. 2002
    ..Since the particulate generation could not be observed at higher temperatures, it was suggested that the complex formation was exothermic and accelerated testing did not predict the stability in terms of particulate generation...
  41. ncbi Enhanced drug dissolution using evaporative precipitation into aqueous solution
    Marazban Sarkari
    Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712 1062, USA
    Int J Pharm 243:17-31. 2002
    ..The high dissolution rates are a consequence of the following advantages of the EPAS process: a small primary particle size, a hydrophilic coating on the particles that enhances wetting, and low crystallinity...
  42. ncbi Improving the dissolution rate of poorly water soluble drug by solid dispersion and solid solution: pros and cons
    Rina J Chokshi
    Applied Pharmaceutical Sciences, University of Rhode Island, Kingston, RI 02881, USA
    Drug Deliv 14:33-45. 2007
    ..Therefore, considering physical stability and in vivo study results, the solid dispersion was the most suitable choice to improve dissolution rates and hence the bioavailability of the poorly water soluble drug...
  43. ncbi Formulation and evaluation of ketorolac transdermal systems
    Jun Shik Choi
    College of Pharmacy, Chosun University, Gwangju, Korea
    Drug Deliv 14:69-74. 2007
    ..There was an excellent relationship found between in vitro permeation flux and in vivo AUC0-infinity...
  44. pmc Variations in captopril formulations used to treat children with heart failure: a survey in the United kingdom
    Hussain Mulla
    Centre for Pharmacy Practice Research, Glenfield Hospital, Leicester, UK
    Arch Dis Child 92:409-11. 2007
    ..The objective of this study was to ascertain the interhospital constancy of unlicensed liquid captopril formulations used to treat children with heart failure in the UK...
  45. ncbi Densitometric determination of diclofenac, 1-(2,6-dichlorophenyl)indolin-2-one and indolin-2-one in pharmaceutical preparations and model solutions
    Jan Krzek
    Department of Inorganic and Analytical Chemistry, Collegium Medicum, Jagiellonian University, 9 Medyczna Str, 30 688 Cracow, Poland
    J Pharm Biomed Anal 28:227-43. 2002
    ..34% and for indolin-2-one--95.85%. The method was used for quality assessment of diclofenac in pharmaceutical preparations. Reliable results comparable to those determined by high performance liquid chromatography (HPLC) were obtained...
  46. doi In vitro and in vivo considerations associated with parenteral sustained release products: a review based upon information presented and points expressed at the 2007 Controlled Release Society Annual Meeting
    Marilyn Martinez
    US Food and Drug Administration, Center for Veterinary Medicine, Office of New Animal Drug Evaluation, Rockville, Maryland 20855, USA
    J Control Release 129:79-87. 2008
  47. ncbi In vivo performance of an oral MR matrix tablet formulation in the beagle dog in the fed and fasted state: assessment of mechanical weakness
    Fiona McInnes
    Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
    Pharm Res 25:1075-84. 2008
    ..To evaluate the behaviour of an oral matrix modified release formulation in the canine gastrointestinal tract, and establish if a mechanical weakness previously observed in clinical studies would have been identified in the dog model...
  48. ncbi A mechanistic study of danazol dissolution in ionic surfactant solutions
    Wei Sun
    Department of Chemical and Petroleum Engineering, University of Kansas, Lawrence, Kansas 66045, USA
    J Pharm Sci 92:424-35. 2003
    ..In that situation, the nuclear magnetic resonance (NMR)-measured drug diffusivity would not be its actual value in the dissolution process...
  49. ncbi Dissolution test for liquid formulations of omeprazole enteric-coated products
    Hye J Jang
    Ann Pharmacother 37:150-1. 2003
  50. ncbi Parallel screening approach to identify solubility-enhancing formulations for improved bioavailability of a poorly water-soluble compound using milligram quantities of material
    Wei Guo Dai
    ALZA Corporation, 1900 Charleston Road, Mountain View, CA 94039, USA
    Int J Pharm 336:1-11. 2007
    ....
  51. ncbi Development and validation of RP-HPLC method for the analysis of metformin
    M Saeed Arayne
    Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 19:231-5. 2006
    ..The proposed method is rapid, accurate, economical and selective and it may be used for the quantitative analysis of metformin in Neodipar tablets because of its sensitivity and reproducibility...
  52. ncbi Oral sustained delivery of paracetamol from in situ gelling xyloglucan formulations
    Shozo Miyazaki
    Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido, Ishikari Tohbetsu, Hokkaido, Japan
    Drug Dev Ind Pharm 29:113-9. 2003
    ....
  53. ncbi Physical and chemical stability of palonosetron hydrochloride with five opiate agonists during simulated Y-site administration
    Lawrence A Trissel
    TriPharma Research, Cashiers, NC 28717 0265, USA
    Am J Health Syst Pharm 64:1209-13. 2007
    ..The physical and chemical compatibility of palonosetron hydrochloride with fentanyl citrate, hydromorphone hydrochloride, meperidine hydrochloride, morphine sulfate, and sufentanil citrate during simulated Y-site administration was studied...
  54. ncbi Development of a simple method for predicting the levels of di(2-ethylhexyl) phthalate migrated from PVC medical devices into pharmaceutical solutions
    Yuji Haishima
    Division of Medical Devices, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Int J Pharm 298:126-42. 2005
    ..significant proportional relationship exists between DEHP release potency and methyl yellow solubility of pharmaceutical solutions, and the risk of DEHP exposure to the patients administered pharmaceuticals through transfusion set could ..
  55. ncbi Rapid determination of lidocaine solutions with non-column chromatographic diode array UV spectroscopy and multivariate calibration
    Kent Wiberg
    AstraZeneca R and D Sodertalje, Analytical Development, Sodertalje, Sweden
    J Pharm Biomed Anal 30:1575-86. 2003
    A new method for the rapid determination of pharmaceutical solutions is proposed. A conventional HPLC system with a Diode Array Detector (DAD) was used with no chromatographic column connected. As eluent, purified water (Milli Q) was used...
  56. ncbi Insulin aspart (AspB28 human insulin) derivatives formed in pharmaceutical solutions
    Mette Uve Jars
    Protein Chemistry, BA, Novo Nordisk A S, Bagsvaerd, Denmark
    Pharm Res 19:621-8. 2002
    ..To isolate and identify the main insulin aspart (AspB28 human insulin) derivatives formed in pharmaceuticals (pH 7.4 at 5 degrees C), to estimate rates of formation, and to determine their biologic potencies...
  57. ncbi Efficiency, thermodynamic and kinetic stability of marketed gadolinium chelates and their possible clinical consequences: a critical review
    Marc Port
    Guerbet, Research Division, Aulnay sous Bois, France
    Biometals 21:469-90. 2008
    ..stability, as demonstrated by numerous in vitro and in vivo studies, resulting in various formulations of pharmaceutical solutions of marketed contrast agents...
  58. ncbi Schedule-dependent potentiation of chemotherapeutic drugs by the bioreductive compounds NLCQ-1 and tirapazamine against EMT6 tumors in mice
    M V Papadopoulou
    The Radiation Medicine Institute, Evanston Northwestern Healthcare, IL 60201, USA
    Cancer Chemother Pharmacol 48:160-8. 2001
    ..Comparisons of schedule-dependent interactions between the hypoxic cytotoxins NLCQ-1/ tirapazamine (TPZ) and various chemotherapeutic drugs in BALB/c mice bearing EMT6 tumors...
  59. ncbi Effect of ethylenediamine on chemical degradation of insulin aspart in pharmaceutical solutions
    Christian Poulsen
    Pharmaceutics, Diabetes Department, Novo Nordisk A S, Novo Alle, room 6B1 58 1, 2880 Bagsvaerd, Denmark
    Pharm Res 25:2534-44. 2008
    ..To examine the effect of different amine compounds on the chemical degradation of insulin aspart at pharmaceutical formulation conditions...
  60. ncbi Evaluation of model solvent systems for assessing the accumulation of container extractables in drug formulations
    D R Jenke
    Center for Physical and Chemical Sciences, Baxter Healthcare Inc, William Graham Science Center, Round Lake, IL 60073, USA
    Int J Pharm 224:51-60. 2001
    ..Of specific concern is the ability of device components to leach into the contacting solution. As pharmaceutical solutions containing surfactants, co-solvents and solubilizing agents become more common, method's for assessing ..
  61. ncbi Significant improvement in sleep in people with intellectual disabilities living in residential settings by non-pharmaceutical interventions
    T Hylkema
    Coordinator sleep wake research Talant, 9244 ZN Beetsterzwaag, The Netherlands
    J Intellect Disabil Res 53:695-703. 2009
    ..Most available studies focus on pharmaceutical solutions. In this study we focus on improving sleep in people with intellectual disabilities living in residential ..
  62. ncbi Detection of IgG aggregation by a high throughput method based on extrinsic fluorescence
    Feng He
    Formulation and Analytical Resources, AW2 D3152, Amgen, Inc, 1201 Amgen Court West, Seattle, Washington, USA
    J Pharm Sci 99:2598-608. 2010
    ..This method may become a powerful high throughput tool to detect IgG aggregates in pharmaceutical solutions and to study other protein properties involving aggregation...
  63. ncbi On-line chemiluminescence determination protocatechuic aldehyde and protocatechuic acid in pharmaceutical preparations by capillary electrophoresis
    Suqin Han
    Institute of Analytical Science, Northwest University, Xi an 710069, China
    J Pharm Biomed Anal 37:733-8. 2005
    ..The detection limits (S/N=3) of PAH and PA were 7.0 x 10(-8)M and 5.0 x10(-8)M, respectively. The proposed method has been satisfactorily applied to the determination of PAH and PA in Salivia miltorrhrza pharmaceutical preparations...
  64. ncbi [UV spectrophotometric assay of famotidine in combination with picrolonic acid, picrolinate]
    M Apostu
    Universitatea de Medicină si Farmacie Gr T Popa Iaşi, Facultatea de Farmacie, Disciplina de Chimie Analitică
    Rev Med Chir Soc Med Nat Iasi 109:422-5. 2005
    ..This method was successfully applied for famotidine assay from pharmaceutical dosage forms...
  65. pmc Formulation and evaluation of taste masked oral reconstitutable suspension of primaquine phosphate
    Punit P Shah
    Pharmacy Department, Center of Relevance and Excellence in NDDS, The M S University of Baroda, G H Patel building, Donor s Plaza, Fatehgunj, Vadodara, Gujarat, India
    AAPS PharmSciTech 9:1025-30. 2008
    ..Taste evaluation of cachets in human volunteers rated tasteless with a score of 0 to DS24 and 3 to DS25. Thus, results conclusively demonstrated successful taste masking and formulation of cachets with taste masked drug...
  66. ncbi Prevention of post-operative infections in spine surgery by wound irrigation with a solution of povidone-iodine and hydrogen peroxide
    Simone Ulivieri
    Department of Neurosurgery, Santa Maria alle Scotte Hospital, Siena, Italy
    Arch Orthop Trauma Surg 131:1203-6. 2011
    ..Starting from January 2009, we systematically irrigated the surgical wounds of patients undergoing spine surgery with a solution of povidone-iodine (PVP-I) and hydrogen peroxide (H(2)O(2))...
  67. pmc Assessment of the accuracy of pharmacy students' compounded solutions using vapor pressure osmometry
    William M Kolling
    School of Pharmacy, Southern Illinois University Edwardsville, 220University Park Drive, Edwardsville, IL 62026, USA
    Am J Pharm Educ 77:58. 2013
    ..CONCLUSIONS. This simple technique of measuring compounding accuracy using a vapor pressure osmometer allowed students to see the importance of quality control and assessment in practice for both pharmacists and technicians...
  68. ncbi Performance characteristics of an ion chromatographic method for the quantitation of citrate and phosphate in pharmaceutical solutions
    Dennis Jenke
    Technology Resources Division, Baxter Healthcare Corporation, Route 120 and Wilson Road, Round Lake, IL 60073, USA
    J Chromatogr Sci 45:50-6. 2007
    The performance of an ion chromatographic method for measuring citrate and phosphate in pharmaceutical solutions is evaluated...
  69. ncbi A stability indicating LC method for zolmitriptan
    B Mallikarjuna Rao
    Analytical Research, Custom Pharmaceutical Services, Dr Reddy s Laboratories, Hyderabad 500049, India
    J Pharm Biomed Anal 39:503-9. 2005
    ..The stress samples were assayed against a qualified reference standard and the mass balance was found close to 99.5%. The developed RP-LC method was validated with respect to linearity, accuracy, precision and robustness...
  70. ncbi Lack of bioequivalence between generic risperidone oral solution and originator risperidone tablets
    S van Os
    Synthon BV, Nijmegen, The Netherlands
    Int J Clin Pharmacol Ther 45:293-9. 2007
    ..Risperidone is an atypical anti-psychotic, available in various formulations...
  71. ncbi Compatibility of ondansetron hydrochloride and methylprednisolone sodium succinate in multilayer polyolefin containers
    Christelle Bougouin
    Pharmacy Service, Caremeau Hospital Medical Center, place du Professeur Debré, 3000 Nîmes, France
    Am J Health Syst Pharm 62:2001-5. 2005
    ..The compatibility of ondansetron hydrochloride and methylprednisolone sodium succinate in 5% dextrose injection and 0.9% sodium chloride injection was studied...
  72. ncbi Secondary relaxations in supercooled and glassy sucrose-borate aqueous solutions
    M Paula Longinotti
    Gerencia de Quimica, Comision Nacional de Energia Atomica, Av General Paz 1499 San Martin, Buenos Aires, Argentina
    Carbohydr Res 343:2650-6. 2008
    ..The behavior observed for water-sucrose and water-sucrose-borate mixtures is compared with previous results obtained in other water-carbohydrate systems...
  73. ncbi Validated HPTLC method of analysis for artemether and its formulations
    Nitin G Tayade
    Department of Pharmaceutics, Bombay College of Pharmacy, Kalina, Santacruz E, Mumbai 400098, India
    J Pharm Biomed Anal 43:839-44. 2007
    ..The limits of detection and quantitation were 65.91 and 197.74 ng per spot, respectively. The method has been successfully applied in the analysis of lipid based parenteral formulations and marketed oral solid dosage formulation...
  74. ncbi Antimony(III)-D, L-tartrates exhibit proton-assisted enantioselective binding in solution and in the gas phase
    Aruna B Wijeratne
    Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX, USA
    J Am Soc Mass Spectrom 20:2100-5. 2009
    ..This finding urges a more in-depth study of mechanisms associated with exhibited enantiomeric resolving capacity of antimony tartrates in HPLC and CE applications, as well as in former ESI-MS association studies...
  75. ncbi Degradation of azo dye active brilliant red X-3B by composite ferrate solution
    G R Xu
    State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, P O Box 2602, 202 Haihe Road, Nangang District, Harbin, Heilongjiang Province, Postal code 150090, China
    J Hazard Mater 161:1299-305. 2009
    ..The complete mineralization of X-3B cannot be achieved under the oxidation by CFS. And a tentative pathway for the oxidative degradation of X-3B was postulated...
  76. ncbi Solutions for lipophilic drugs: a biodegradable polymer acting as solvent, matrix, and carrier to solve drug delivery issues
    Lutz R Asmus
    School of Pharmaceutical Sciences, University of Geneva and University of Lausanne, Geneva, Switzerland
    Int J Artif Organs 34:238-42. 2011
    ..HexPLA is shown to be a potent solvent and excipient for lipophilic drugs, allowing the initial burst of drug release to be modified and controlled...
  77. ncbi Simultaneous determination of synephrine, arecoline, and norisoboldine in Chinese patent medicine Si-Mo-Tang oral liquid preparation by strong cation exchange high performance liquid chromatography
    Yue Neng Yi
    College of Chemistry and Chemical Engineering, Central South University, Changsha, China
    Pharm Biol 50:832-8. 2012
    ..Studies of SMT have been impeded due to the lack of quality control methods...
  78. ncbi Pharmacokinetics and tissue distribution of larotaxel in rats: comparison of larotaxel-loaded microsphere with larotaxel-solution
    Zhenzhen Liu
    School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road 103, Shenhe District, Shenyang 110016, China
    Cancer Chemother Pharmacol 71:1131-9. 2013
    ....
  79. ncbi Simultaneous quantification of promazine hydrochloride and its sulfoxide in pharmaceutical preparations
    J Karpinska
    Institute of Chemistry, University of Bialystok, Poland
    Anal Sci 17:249-53. 2001
    ..An elaborated method was successfully used to determine analytes in commercial promazine pharmaceuticals. The obtained results agreed well with those obtained by the HPLC method...
  80. ncbi Stability and transdermal absorption of topical amphotericin B liposome formulations
    A Manosroi
    Pharmaceutical Cosmetics Raw Materials and Natural Products Research and Development Center, Faculty of Pharmacy, Institute for Science and Technology Research and Development, Chiang Mai University, Chiang Mai 50200, Thailand
    Int J Pharm 270:279-86. 2004
    ..AmB entrapped in charged liposomes showed sustained skin absorption. The positively charged liposome might be the best formulation for AmB, due to its higher stability than other formulations...
  81. ncbi Transdermal delivery of ketorolac tromethamine: effects of vehicles and penetration enhancers
    Young Ah Cho
    College of Pharmacy, Chosun University, Gwangju, Korea
    Drug Dev Ind Pharm 30:557-64. 2004
    ..The highest enhancing effect was attained with 10% caprylic acid in PG; the permeation flux was 113.6 +/- 17.5 microg/cm2/h. The lag time of KT was reduced as the concentration of fatty acids increased except for caprylic acid...
  82. ncbi Spinal chloroprocaine solutions: density at 37 degrees C and pH titration
    Kimberly B Na
    Department of Anesthesiology, Virginia Mason Medical Center, 1100 Ninth Avenue, B2 AN, Seattle, WA 98111, USA
    Anesth Analg 98:70-4, table of contents. 2004
    ..0), but the pH can be increased to more than 7.0 with a small amount of bicarbonate (0.25-0.33 mL/10 mL). The increased density of plain chloroprocaine makes it a useful hyperbaric spinal drug without the addition of dextrose...
  83. ncbi Influence of histidine on the stability and physical properties of a fully human antibody in aqueous and solid forms
    Bei Chen
    Department of Process Sciences, Abgenix, Inc, Fremont, CA 94555, USA
    Pharm Res 20:1952-60. 2003
    ..The aim of the study was to investigate the effect of histidine on the stability and physical properties of a fully human anti-IL8 monoclonal antibody (ABX-IL8) in aqueous and solid forms...
  84. ncbi [A novel gemcitabine delivery system]
    Akio Sugitachi
    Dept of Surgery, Iwate Medical University
    Gan To Kagaku Ryoho 38:2445-7. 2011
    ..These suggested that our devised system would be clinically useful as a novel tool in cancer chemotherapy...
  85. ncbi Solubility and phase separation of benzocaine and salicylic acid in 1,4-dioxane-water mixtures at several temperatures
    M Angeles Peña
    Departamento de Farmacia y Tecnologia Farmaceutica, Facultad de Farmacia, Universidad de Alcala, Alcala de Henares, E 28871 Madrid, Spain
    J Pharm Biomed Anal 36:571-8. 2004
    ..Both drugs showed a nonlinear pattern of enthalpy-entropy compensation...
  86. ncbi [Effects of packaging forms on the stability of vitamin B1 and vitamin C in TPN admixtures]
    Daisuke Hashimoto
    Information Center for Infusion Therapy and Product, Otsuka Pharmaceutical Factory, Inc
    Gan To Kagaku Ryoho 37:293-5. 2010
    ..However, the decrease in vitamin C content was observed when there was a long time-lag between a preparation and a packaging. We thought it was desirable to pack the TPN bag promptly after the preparation...
  87. ncbi Various irrigation fluids affect postoperative brain edema and cellular damage during experimental neurosurgery in rats
    Kazuhisa Doi
    Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc, Tokushima 772 8601, Japan
    Surg Neurol 66:565-71; discussion 571-2. 2006
    ..This study was conducted to investigate how various irrigation fluids used during neurosurgical procedures affect the degree of postoperative brain edema and cellular damage during experimental neurosurgery in rats...
  88. pmc Influence of formulation and processing variables on properties of itraconazole nanoparticles made by advanced evaporative precipitation into aqueous solution
    Stephanie Bosselmann
    Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, 1 University Station, Mail Stop A1920, Austin, Texas 78712, USA
    AAPS PharmSciTech 13:949-60. 2012
    ..The use of sucrose prevented particle agglomeration and resulted in powders that were readily reconstituted and reached high and sustained supersaturation levels upon dissolution in aqueous media...
  89. ncbi Bioequivalence study of levothyroxine tablets compared to reference tablets and an oral solution
    Rossen Koytchev
    Cooperative Clinical Drug Research and Development, Neuenhagen Germany
    Arzneimittelforschung 54:680-4. 2004
    ..The results of the present trial confirm the findings of a previous study, performed under steady-state conditions with Eferox tablets 100 microg in patients without thyroid function...
  90. ncbi Administration of a lighter-coloured methadone liquid
    Andrew Byrne
    Drug Alcohol Rev 21:405. 2002
  91. ncbi Rapid intervention for an episode of malignant hyperthermia
    Daniel Chartrand
    Can J Anaesth 50:104-7. 2003
  92. ncbi Activity coefficients of antibiotics in aqueous NaCl solutions at 298.2 K
    Jan M Hamelink
    Dept of Chemical Engineering, McGill University, Montreal, H3A 2B2, Quebec, Canada
    Biophys Chem 95:97-108. 2002
    ..The correlation of solubility data using the activity coefficients measured in this work shows the same puzzling results previously observed in systems containing amino acids...
  93. ncbi Spectrophotometric determination of manidipine dihydrochloride based on formation of charge-transfer complex with iodine
    N De Laurentis
    Department of Medicinal Chemistry-Faculty of Pharmacy, University of Bari, Italy
    Boll Chim Farm 140:15-9. 2001
    ..The method can be applied successfully to the analysis of commercially available manidipine dihydrochloride tablets...
  94. ncbi Investigations on the predictability of the formation of glassy solid solutions of drugs in sugar alcohols
    M Langer
    Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
    Int J Pharm 252:167-79. 2003
    ..In irregular mixtures of drugs and sugar alcohols, an excess entropy and the formation of hydrogen bonds between unlike molecules favor miscibility, that cannot be predicted by regular solution theory...
  95. ncbi Effects of ethanol to water ratio in feed solution on the crystallinity of spray-dried lactose
    Päivi Harjunen
    Department of Pharmaceutics, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Drug Dev Ind Pharm 28:949-55. 2002
    ..Surface area of the spray-dried lactose increased as a function of amorphous content...
  96. ncbi Chemical analysis of freshly prepared and stored capsaicin solutions: implications for tussigenic challenges
    Scott E Kopec
    The Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Pulm Pharmacol Ther 15:529-34. 2002
    ..033). We conclude that the actual concentration of capsaicin solution is less than predicted, and solutions of 4 microM or higher concentration are stable for 1 year if stored at 4 degrees C protected from light...
  97. ncbi Optimization in development of acetaminophen syrup formulation
    Nimit Worakul
    Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Thailand
    Drug Dev Ind Pharm 28:345-51. 2002
    ..Formulators could customize the optimal formulation according to their needs and cost constraints by redefining the desirable outcomes in the source code of the program...
  98. ncbi Modifying the bitterness of selected oral pharmaceuticals with cation and anion series of salts
    Russell S J Keast
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA
    Pharm Res 19:1019-26. 2002
    ..The purpose of this study was to examine the influence of a variety of cations and anions on the bitterness of selected oral pharmaceuticals and bitter taste stimuli: pseudoephedrine, ranitidine, acetaminophen, quinine, and urea...
  99. ncbi [Stability of busulfan injection solution (Busilvex, Busulfex) in B/Braun Injekt syringes]
    A Karstens
    Apotheke des Klinikums der Johannes Gutenberg Universität Mainz, Germany
    Pharmazie 61:845-50. 2006
    ..Unused busulfan injection (Busilvex, Busulfex) is not necessarily to be discarded, but can be stored for a prolonged period of time in a rubber free syringe, preferably under refrigeration...
  100. ncbi Effect of coefficient of viscosity and ambient temperature on the flow rate of drug solutions in infusion pumps
    Yoshinori Kawabata
    Department of Pharmacy, Niigata Cancer Center Hospital, Kawagishi cho, Chuo Ku, Niigata, Japan
    Pharm Dev Technol 17:755-62. 2012
    ..The duration of continuous 5-FU infusion is normally set at an average of 46 h, but large variations in the duration of infusion are observed...
  101. pmc Understanding and modulating opalescence and viscosity in a monoclonal antibody formulation
    Branden A Salinas
    Department of Chemical and Biological Engineering, University of Colorado, Boulder, Colorado, USA
    J Pharm Sci 99:82-93. 2010
    ....

Research Grants9

  1. A RANDOMIZED CONTROLLED TRIAL OF ECHINACEA IN CHILDREN
    James Taylor; Fiscal Year: 2001
    ..abstract_text> ..
  2. PSYCHOPHYSICAL INVESTIGATION OF UMAMI TASTE
    Russell Keast; Fiscal Year: 2004
    ..abstract_text> ..
  3. Elucidation of the Lipoxygenase-Mediated Pathway of Lun*
    PAUL MYRDAL; Fiscal Year: 2005
    ..abstract_text> ..
  4. Digoxin Chiral Isolates as Improved Pharmaceuticals
    John Somberg; Fiscal Year: 2005
    ..The advantage would be a treatment for AF that did not cause cardiac augmentation and vasoconstriction or a treatment for CHF that does not cause heart rate slowing or conduction disturbances. ..
  5. The Feasibility of Assessing the Prevalence of Rickets
    James Taylor; Fiscal Year: 2006
    ..In addition to assessing possible methodologies for the larger project, the preliminary study is designed to yield standalone results with important implications. [unreadable] [unreadable] [unreadable]..
  6. Bronx-Lebanon Hospital Center Pediatric ACTU
    Murli Purswani; Fiscal Year: 2006
    ..abstract_text> ..
  7. Host-Response Relationships in Patients with Candidemia
    Melissa Johnson; Fiscal Year: 2006
    ....
  8. Antiretroviral Pharmacology/Lactating Mother/Infants
    Mark Mirochnick; Fiscal Year: 2006
    ..This information is needed for the safe and effective use of antiretrovirals in nursing women, and will pioneer a novel approach to the study of breast milk drug transfer. ..
  9. Safety Pharmacokinetics & Efficacy of Artemether & Lumefantrine in Pregnant Women
    Mark Mirochnick; Fiscal Year: 2008
    ..The data from this planned study will provide the information needed to ensure that pregnant women receive the appropriate doses of these anti-malaria drugs. [unreadable] [unreadable] [unreadable]..