emulsions

Summary

Summary: Colloids of two immiscible liquids where either phase may be either fatty or aqueous; lipid-in-water emulsions are usually liquid, like milk or lotion and water-in-lipid emulsions tend to be creams.

Top Publications

  1. ncbi Formulation development and optimization of a novel Cremophore EL-based nanoemulsion using ultrasound cavitation
    Siah Ying Tang
    Department of Chemical and Environmental Engineering, Faculty of Engineering, The University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Malaysia
    Ultrason Sonochem 19:330-45. 2012
  2. ncbi Amplification of complex gene libraries by emulsion PCR
    Richard Williams
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    Nat Methods 3:545-50. 2006
  3. ncbi Topical transport of hydrophilic compounds using water-in-oil nanoemulsions
    H Wu
    Department of Pharmaceutics, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA
    Int J Pharm 220:63-75. 2001
  4. ncbi Superhydrophobic and superoleophilic PVDF membranes for effective separation of water-in-oil emulsions with high flux
    Wenbin Zhang
    i LAB and Nano bionics Division, Suzhou Institute of Nano tech and Nano bionics, Chinese Academy of Sciences, Suzhou 215123, China
    Adv Mater 25:2071-6. 2013
  5. ncbi Microemulsion-based media as novel drug delivery systems
    M J Lawrence
    Department of Pharmacy, King s College London, Franklin Wilkins Building, 150 Stamford Street, SE1 9NN, London, UK
    Adv Drug Deliv Rev 45:89-121. 2000
  6. ncbi Enhanced bioavailability of silymarin by self-microemulsifying drug delivery system
    Wei Wu
    School of Pharmacy, Fudan University, Shanghai, China
    Eur J Pharm Biopharm 63:288-94. 2006
  7. ncbi Development and bioavailability assessment of ramipril nanoemulsion formulation
    Sheikh Shafiq
    Department of Pharmaceutics, Jamia Hamdard, Hamdard Nagar, India
    Eur J Pharm Biopharm 66:227-43. 2007
  8. ncbi Development of multiple W/O/W emulsions as dermal carrier system for oligonucleotides: effect of additives on emulsion stability
    T Schmidts
    Institute of Biopharmaceutical Technology, University of Applied Sciences Giessen Friedberg, 35390 Giessen, Germany
    Int J Pharm 398:107-13. 2010
  9. ncbi Microemulsions--modern colloidal carrier for dermal and transdermal drug delivery
    Sandra Heuschkel
    Faculty of Biosciences, Institute for Pharmacy, Pharmaceutics and Biopharmaceutics, Martin Luther University Halle Wittenberg, Wolfgang Langenbeck Str 4, 06120 Halle Saale, Germany
    J Pharm Sci 97:603-31. 2008
  10. pmc Novel formulation of a methotrexate derivative with a lipid nanoemulsion
    Juliana A Moura
    Heart Institute of the Medical School Hospital, University of Sao Paulo, Sao Paulo, Brazil
    Int J Nanomedicine 6:2285-95. 2011

Detail Information

Publications324 found, 100 shown here

  1. ncbi Formulation development and optimization of a novel Cremophore EL-based nanoemulsion using ultrasound cavitation
    Siah Ying Tang
    Department of Chemical and Environmental Engineering, Faculty of Engineering, The University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Malaysia
    Ultrason Sonochem 19:330-45. 2012
    ..30. This study proved that the use of low frequency ultrasound is of considerable importance in the controlled production of pharmaceutical nanoemulsions in the drug delivery system...
  2. ncbi Amplification of complex gene libraries by emulsion PCR
    Richard Williams
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    Nat Methods 3:545-50. 2006
  3. ncbi Topical transport of hydrophilic compounds using water-in-oil nanoemulsions
    H Wu
    Department of Pharmaceutics, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA
    Int J Pharm 220:63-75. 2001
    ....
  4. ncbi Superhydrophobic and superoleophilic PVDF membranes for effective separation of water-in-oil emulsions with high flux
    Wenbin Zhang
    i LAB and Nano bionics Division, Suzhou Institute of Nano tech and Nano bionics, Chinese Academy of Sciences, Suzhou 215123, China
    Adv Mater 25:2071-6. 2013
    ..separation of both micrometer and nanometer-sized surfactant-free and surfactant-stabilized water-in-oil emulsions solely driven by gravity, with high separation efficiency (oil purity in filtrate after separation > 99...
  5. ncbi Microemulsion-based media as novel drug delivery systems
    M J Lawrence
    Department of Pharmacy, King s College London, Franklin Wilkins Building, 150 Stamford Street, SE1 9NN, London, UK
    Adv Drug Deliv Rev 45:89-121. 2000
    ..The use of microemulsions and closely related microemulsion-based systems as drug delivery vehicles is reviewed, with particular emphasis being placed on recent developments and future directions...
  6. ncbi Enhanced bioavailability of silymarin by self-microemulsifying drug delivery system
    Wei Wu
    School of Pharmacy, Fudan University, Shanghai, China
    Eur J Pharm Biopharm 63:288-94. 2006
    ..Alternative mechanisms, such as improved lymphatic transport pathway, other than improved release may contribute to enhancement of bioavailability of silymarin...
  7. ncbi Development and bioavailability assessment of ramipril nanoemulsion formulation
    Sheikh Shafiq
    Department of Pharmaceutics, Jamia Hamdard, Hamdard Nagar, India
    Eur J Pharm Biopharm 66:227-43. 2007
    ..49%. The present study revealed that ramipril nanoemulsion could be used as a liquid formulation for pediatric and geriatric patients and can be formulated as self-nanoemulsifying drug delivery system (SNEDDS) as a unit dosage form...
  8. ncbi Development of multiple W/O/W emulsions as dermal carrier system for oligonucleotides: effect of additives on emulsion stability
    T Schmidts
    Institute of Biopharmaceutical Technology, University of Applied Sciences Giessen Friedberg, 35390 Giessen, Germany
    Int J Pharm 398:107-13. 2010
    Multiple water-in-oil-in-water (W/O/W) emulsions are of major interest as potential skin delivery systems for water-soluble drugs like oligonucleotides due to their distinct encapsulation properties...
  9. ncbi Microemulsions--modern colloidal carrier for dermal and transdermal drug delivery
    Sandra Heuschkel
    Faculty of Biosciences, Institute for Pharmacy, Pharmaceutics and Biopharmaceutics, Martin Luther University Halle Wittenberg, Wolfgang Langenbeck Str 4, 06120 Halle Saale, Germany
    J Pharm Sci 97:603-31. 2008
    ..However, an extended use in practice depends on the choice of well-tolerated ingredients, mainly surfactants, and the restriction of their amounts in order to guarantee skin compatibility...
  10. pmc Novel formulation of a methotrexate derivative with a lipid nanoemulsion
    Juliana A Moura
    Heart Institute of the Medical School Hospital, University of Sao Paulo, Sao Paulo, Brazil
    Int J Nanomedicine 6:2285-95. 2011
    ..The aim of this study was to develop a new formulation using a lipophilic derivative of methotrexate, ie, didodecyl methotrexate (ddMTX), associated with a lipid nanoemulsion (ddMTX-LDE)...
  11. ncbi The influence of cosurfactants and oils on the formation of pharmaceutical microemulsions based on PEG-8 caprylic/capric glycerides
    Ljiljana Djekic
    Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, Vojvode Stepe 450, P O Box 146, 11221 Belgrade, Serbia
    Int J Pharm 352:231-9. 2008
    ..18% (w/w) and W(max), 65.00% (w/w) for PO) and the electrical conductivity measurement results for optimized balanced microemulsions showed that their structures were highly conductive indicating a bicontinuous microstructure...
  12. ncbi Comparison of solid self-microemulsifying drug delivery system (solid SMEDDS) prepared with hydrophilic and hydrophobic solid carrier
    Dong Hoon Oh
    College of Pharmacy, Yeungnam University, 214 1, Dae Dong, Gyongsan 712 749, South Korea
    Int J Pharm 420:412-8. 2011
    ..Thus, except appearance, hydrophilic carrier (dextran) and hydrophobic carrier (colloidal silica) hardly affected the formation of solid SMEDDS such as crystalline properties, dissolution and oral bioavailability...
  13. ncbi Enhanced oral bioavailability of Coenzyme Q10 by self-emulsifying drug delivery systems
    Prabagar Balakrishnan
    College of Pharmacy, Yeungnam University, 214 1 Dae Dong, Gyongsan, South Korea
    Int J Pharm 374:66-72. 2009
    ..05). Thus, this self-micro emulsifying drug delivery system should be an effective oral dosage form for improving oral bioavailability of lipophilic drug, CoQ(10)...
  14. ncbi Oral bioavailability enhancement of acyclovir by self-microemulsifying drug delivery systems (SMEDDS)
    Deepa Patel
    TIFAC CORE IN NDDS, Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Vadodara, India
    Drug Dev Ind Pharm 33:1318-26. 2007
    ..5 fold increase in bioavailability compared with the pure drug solution. Our studies illustrated the potential use of SMEDDS for the delivery of hydrophobic compounds such as acyclovir by oral route...
  15. ncbi Effect of water/fuel emulsions and a cerium-based combustion improver additive on HD and LD diesel exhaust emissions
    Arianna Farfaletti
    EU Joint Research Centre Ispra, Institute for Environment and Sustainability, Emissions and Health Unit, 21020 Ispra VA, Italy
    Environ Sci Technol 39:6792-9. 2005
    ..It is well known that water/diesel (W/ D) emulsions with up to 20% water can reduce PM and NOx emissions in heavy-duty (HD) engines...
  16. pmc Nanocarrier for the transdermal delivery of an antiparkinsonian drug
    Adnan Azeem
    Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi, 110062, India
    AAPS PharmSciTech 10:1093-103. 2009
    ..5-fold increase in skin permeation rate when compared to the conventional hydrogel. In conclusion, the results of the present investigation suggested a promising role of nanoemulsions in enhancing the transdermal permeation of ropinirole...
  17. pmc Mechanisms of nucleotide trafficking during siRNA delivery to endothelial cells using perfluorocarbon nanoemulsions
    Megan M Kaneda
    Biomedical Engineering, Washington University School of Medicine, St Louis, MO 63108, USA
    Biomaterials 31:3079-86. 2010
    ..We further demonstrate markedly enhanced efficacy over conventional transfection agents for suppressing endothelial cell expression of upregulated vascular adhesion molecules...
  18. ncbi Self-emulsifying drug delivery systems: an approach to enhance oral bioavailability
    Kanchan Kohli
    Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi 62, India
    Drug Discov Today 15:958-65. 2010
    ....
  19. pmc A programmable microenvironment for cellular studies via microfluidics-generated double emulsions
    Ying Zhang
    Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
    Biomaterials 34:4564-72. 2013
    ..A solution is to entrap W/O droplets in another aqueous phase, forming water-in-oil-in-water (W/O/W) double emulsions. The external aqueous phase efficiently prevents desiccation and reduces the amount of organic component, and ..
  20. ncbi Design and characterization of antitumor drug paclitaxel-loaded chitosan nanoparticles by W/O emulsions
    Juan Xu
    State Key Laboratory of Chemical Resource Engineering, Key Laboratory of Carbon Fiber and Functional Polymers, Ministry of Education, Beijing University of Chemical Technology, Beijing, PR China
    Int J Biol Macromol 50:438-43. 2012
    ..55% and 94.01%, respectively. In vitro drug release profile was also determined by ultraviolet spectrometry. MTT assays revealed that the blank chitosan nanoparticles had almost none toxicity, and cell culture was carried out accordingly...
  21. ncbi Enhanced oral bioavailability of puerarin using microemulsion vehicle
    Hongfei Wu
    Department of Pharmaceutics, Anhui University of Traditional Chinese Medicine, Anhui Province Key Laboratory of R and D of Chinese Medicine, Hefei, P R China
    Drug Dev Ind Pharm 35:138-44. 2009
    ..Puerarin microemulsion also showed good stability. These studies showed that microemulsion system of puerarin might be promising vehicles for the peroral delivery of puerarin...
  22. ncbi BEAMing: single-molecule PCR on microparticles in water-in-oil emulsions
    Frank Diehl
    The Howard Hughes Medical Institute, and The Ludwig Center for Cancer Genetics and Therapeutics, The Johns Hopkins Kimmel Cancer Center, 1650 Orleans Street, Baltimore, Maryland 21231, USA
    Nat Methods 3:551-9. 2006
  23. ncbi Preparation of nimodipine-loaded microemulsion for intranasal delivery and evaluation on the targeting efficiency to the brain
    Qizhi Zhang
    Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 200032, PR China
    Int J Pharm 275:85-96. 2004
    ..v. administration. These results suggest that the microemulsion system is a promising approach for intranasal delivery of NM for the treatment and prevention of neurodegenerative diseases...
  24. ncbi Enhancement of oral bioavailability of atorvastatin calcium by self-emulsifying drug delivery systems (SEDDS)
    Pawan J Kadu
    R C Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule, Maharashtra, India
    Pharm Dev Technol 16:65-74. 2011
    ..The formulation significantly reduced serum lipid levels as compared with atorvastatin calcium. Thus studies illustrated the potential use for the delivery of hydrophobic drug such as atorvastatin calcium by oral route...
  25. pmc Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions
    Natalya Rapoport
    Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA
    J Control Release 153:4-15. 2011
    ..Anticipated mechanisms of the observed effects are discussed...
  26. ncbi Deposition of free cholesterol in the blood vessels of patients with coronary artery disease: a possible novel mechanism for atherogenesis
    Ricardo D Couto
    Lipid Metabolism Laboratory and the Surgical Division, the Heart Institute InCor of the Medical School Hospital, University of Sao Paulo, Sao Paulo, Brazil
    Lipids 42:411-8. 2007
    ..Considering LDE as an artificial nanoemulsion model for LDL, our results suggest that dissociation of FC from lipoprotein particles and deposition in the vessel wall may play a role as an independent mechanism in atherogenesis...
  27. ncbi Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs
    R Neslihan Gursoy
    Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 06100 Ankara, Turkey
    Biomed Pharmacother 58:173-82. 2004
    ..can be orally administered in soft or hard gelatin capsules and form fine relatively stable oil-in-water (o/w) emulsions upon aqueous dilution owing to the gentle agitation of the gastrointestinal fluids...
  28. pmc Comparison of the ocular tolerability of a latanoprost cationic emulsion versus conventional formulations of prostaglandins: an in vivo toxicity assay
    Hong Liang
    Paris Descartes University, Faculty of Biological and Pharmacological Sciences, Department of Toxicology, Paris, France
    Mol Vis 15:1690-9. 2009
    ..005% latanoprost, 0.004% travoprost, 0.03% bimatoprost (containing 0.02%, 0.015%, and 0.005% BAC, respectively), and 0.005% latanoprost in a new cationic emulsion (LCEm) formulation...
  29. pmc Simultaneous transfer of cholesterol, triglycerides, and phospholipids to high-density lipoprotein in aging subjects with or without coronary artery disease
    Carolina H M Azevedo
    Lipid Metabolism Laboratory, Heart Institute, Faculdade de Medicina da Universidade de Sao Paulo, Brazil
    Clinics (Sao Paulo) 66:1543-8. 2011
    ..To verify whether the capacity of high-density lipoprotein (HDL) to simultaneously receive nonesterified cholesterol, triglycerides, cholesteryl esters, and phospholipids changes with aging and the presence of coronary artery disease...
  30. ncbi Polymer-based nanocapsules for drug delivery
    C E Mora-Huertas
    Universite de Lyon, F 69622, Lyon, France
    Int J Pharm 385:113-42. 2010
    ..Consequently, the information obtained allows establishing criteria for selecting a method for preparation of nanocapsules according to its advantages, limitations and behaviours as a drug carrier...
  31. ncbi Microemulsions for topical delivery of estradiol
    S Peltola
    Department of Pharmaceutics, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    Int J Pharm 254:99-107. 2003
    ..extensive first pass metabolism after oral administration, transdermal administration of estradiol in gels and emulsions has been used to improve its bioavailability, prolong activity and to optimize metabolic profile...
  32. ncbi Transdermal delivery of hydrocortisone from eucalyptus oil microemulsion: effects of cosurfactants
    Gamal M El Maghraby
    Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, P O Box 2457, Saudi Arabia
    Int J Pharm 355:285-92. 2008
    ..Ethanol produced the greatest effect followed by propylene glycol and isopropanol. The presence of cosurfactant and its type can thus affect both the phase behavior and the transdermal delivery potential of microemulsion...
  33. ncbi Microemulsions: an overview and pharmaceutical applications
    S Tenjarla
    Serquest, a Southern Research Institute Company, Birmingham, AL 35205, USA
    Crit Rev Ther Drug Carrier Syst 16:461-521. 1999
    ..Several references are cited, but the list is by no means exhaustive. The review is written so that a newcomer to the field can easily grasp the important facts pertaining to this novel delivery system...
  34. ncbi The effect of lidocaine on the globule size distribution of propofol emulsions
    Jong Woo Park
    Department of Pharmaceutics, College of Pharmacy, Sungkyunkwan University, Suwon, South Korea
    Anesth Analg 97:769-71. 2003
    ..Its increase was minimized by the addition of L-lysine to the propofol emulsion...
  35. ncbi Cremophor-free intravenous microemulsions for paclitaxel II. Stability, in vitro release and pharmacokinetics
    Adwoa O Nornoo
    Department of Pharmaceutical Sciences, Albany College of Pharmacy, Albany, NY 12208, USA
    Int J Pharm 349:117-23. 2008
    ....
  36. pmc Preparation and in vivo evaluation of SMEDDS (self-microemulsifying drug delivery system) containing fenofibrate
    Ashok R Patel
    Centre for Novel Drug Delivery Systems, Department of Pharmaceutical Sciences, University Institute of Chemical Technology, Matunga, Mumbai, India
    AAPS J 9:E344-52. 2007
    ..Thus, the study confirmed that the SMEDDS formulation can be used as a possible alternative to traditional oral formulations of fenofibrate to improve its bioavailability...
  37. ncbi Biocompatible surfactants for water-in-fluorocarbon emulsions
    C Holtze
    Department of Physics and School of Engineering and Applied Sciences, Harvard University, Cambridge, USA
    Lab Chip 8:1632-9. 2008
    Drops of water-in-fluorocarbon emulsions have great potential for compartmentalizing both in vitro and in vivo biological systems; however, surfactants to stabilize such emulsions are scarce...
  38. ncbi Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10: formulation development and bioavailability assessment
    T R Kommuru
    School of Pharmacy, University of Louisiana at Monroe, 700 University Avenue, Monroe, LA 71209, USA
    Int J Pharm 212:233-46. 2001
    ..SEDDS have improved the bioavailability of CoQ10 significantly. The data suggest the potential use of SEDDS to provide an efficient way of improving oral absorption of lipophilic drugs...
  39. ncbi Neuroprotective effect of erythropoietin-loaded composite microspheres on retinal ganglion cells in rats
    Xianfang Rong
    Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Shanghai Medical College, Fudan University, No 83 Fenyang Road, Shanghai, China
    Eur J Pharm Sci 43:334-42. 2011
    ..So we can draw a conclusion that the EPO-loaded PLGA/PLA microspheres were feasible for neurodegeneration diseases in the retina and central nervous system (CNS)...
  40. ncbi Solid lipid nanoparticles for enhancing vinpocetine's oral bioavailability
    Yifan Luo
    School of Pharmacy, Department of Pharmaceutics, Mailbox 42, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016 Liaoning, P R China
    J Control Release 114:53-9. 2006
    ..These results indicated that VIN absorption is enhanced significantly by employing SLN formulations. SLNs offer a new approach to improve the oral bioavailability of poorly soluble drugs...
  41. ncbi Development of protein delivery microsphere system by a novel S/O/O/W multi-emulsion
    Weien Yuan
    Shanghai Jiaotong University, School of Pharmacy, 800 Dongchuan Road, Shanghai 200240, People s Republic of China
    Eur J Pharm Sci 36:212-8. 2009
    ..The dextran glassy particles can stabilize proteins in the PLGA matrix, which is the major advantage of this novel protein sustained-release system over preparation for the PLGA microspheres using W/O/W double-emulsion method...
  42. ncbi Effectiveness, safety, and pharmacokinetic and pharmacodynamic characteristics of microemulsion propofol in patients undergoing elective surgery under total intravenous anaesthesia
    J A Jung
    Department of Clinical Pharmacology and Therapeutics, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Pungnap 2 dong, Songpa Gu, Seoul 138 736, Korea
    Br J Anaesth 104:563-76. 2010
    ..The aims of this study were to investigate the effectiveness, safety, pharmacokinetics, and pharmacodynamics of microemulsion propofol, Aquafol (Daewon Pharmaceutical Co., Ltd, Seoul, Republic of Korea)...
  43. ncbi Enhanced bioavailability of lacidipine via microemulsion based transdermal gels: formulation optimization, ex vivo and in vivo characterization
    Ramesh Gannu
    National Facilities in Engineering and Technology with Industrial Collaboration NAFETIC Centre, University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506 009, Andhra Pradesh, India
    Int J Pharm 388:231-41. 2010
    ..Microemulsion based transdermal therapeutic system of LCDP was developed and optimized using Box-Behnken statistical design and could provide an effective treatment in the management of hypertension...
  44. ncbi Formulation design of microemulsion for dermal delivery of penciclovir
    Weiwei Zhu
    Department of Pharmaceutics, College of Pharmacy, Shandong University, Jinan 250012, China
    Int J Pharm 360:184-90. 2008
    ..5 times that of the commercial cream. The conclusion was that the permeating ability of penciclovir was significantly increased from the microemulsion formulation compared with commercial cream...
  45. ncbi PLGA nanoparticles of different surface properties: preparation and evaluation of their body distribution
    Farnaz Esmaeili
    Novel Drug Delivery Systems Laboratory, Department of Pharmaceutics, Faculty of Pharmacy, Medical Sciences University of Tehran, P O Box 14155 6451, Tehran, Iran
    Int J Pharm 349:249-55. 2008
    ....
  46. pmc Nanoparticles engineered from lecithin-in-water emulsions as a potential delivery system for docetaxel
    Nijaporn Yanasarn
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, United States
    Int J Pharm 379:174-80. 2009
    ..the engineering of a novel spherical nanoparticle formulation ( approximately 270 nm) from lecithin-in-water emulsions. Docetaxel can be incorporated into the nanoparticles, and the resultant docetaxel-nanoparticles were stable ..
  47. ncbi Lipid-based delivery systems for improving the bioavailability and lymphatic transport of a poorly water-soluble LTB4 inhibitor
    D J Hauss
    Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut 06877 0368, USA
    J Pharm Sci 87:164-9. 1998
    ....
  48. pmc Pre-clinical evaluation of a novel nanoemulsion-based hepatitis B mucosal vaccine
    Paul E Makidon
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 3:e2954. 2008
    ..A new nasal hepatitis B vaccine composed of recombinant hepatitis B surface antigen (HBsAg) in a novel nanoemulsion (NE) adjuvant (HBsAg-NE) could be effective with fewer administrations...
  49. ncbi Docetaxel microemulsion for enhanced oral bioavailability: preparation and in vitro and in vivo evaluation
    Yong Mei Yin
    College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
    J Control Release 140:86-94. 2009
    ..These results encourage further development of docetaxel microemulsions as an oral drug delivery system...
  50. ncbi Enhanced humoral and Type 1 cellular immune responses with Fluzone adjuvanted with a synthetic TLR4 agonist formulated in an emulsion
    Susan L Baldwin
    Infectious Disease Research Institute, 1124 Columbia Street, Suite 400, Seattle, WA 98104, United States
    Vaccine 27:5956-63. 2009
    ....
  51. ncbi Microemulsion formulation for enhanced absorption of poorly soluble drugs. II. In vivo study
    Kohsaku Kawakami
    Developmental Research Laboratories, Shionogi and Co, Ltd, 12 4 Sagisu 5 chome, Fukushima ku, 553 0002, Osaka, Japan
    J Control Release 81:75-82. 2002
    ..HCO-60 and Tween 80-based formulations were mild to the organs, while BL-9EX-based formulation caused serious damage. The behavior and absorption mechanism of the microemulsion formulations are discussed...
  52. ncbi Characterization of water-in-oil microemulsion for oral delivery of earthworm fibrinolytic enzyme
    Mao Bo Cheng
    Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    J Control Release 129:41-8. 2008
    ..These findings indicated that the w/o microemulsion may represent a safe and effective oral delivery system for hydrophilic bioactivity macromolecules...
  53. pmc Enhanced effect and mechanism of water-in-oil microemulsion as an oral delivery system of hydroxysafflor yellow A
    Jianping Qi
    School of Pharmacy, China Pharmaceutical University, Nanjing, People s Republic of China
    Int J Nanomedicine 6:985-91. 2011
    ..In this paper, a water-in-oil (w/o) microemulsion was investigated as a system for enhancing the oral bioavailability of Biopharmaceutic Classification System (BCS) III drugs...
  54. ncbi Importance of bacterial surface properties to control the stability of emulsions
    Mai Huong Ly
    Laboratoire de Microbiologie UMR UB INRA 1232, ENSBANA, 1, Esplanade Erasme 21000 Dijon, France
    Int J Food Microbiol 112:26-34. 2006
    In colloidal media such as emulsions or food matrixes, the stability results from physicochemical interactions...
  55. ncbi Formulation, antimalarial activity and biodistribution of oral lipid nanoemulsion of primaquine
    Kamalinder K Singh
    C U Shah College of Pharmacy, S N D T Women s University, Santacruz W, Mumbai 400049, India
    Int J Pharm 347:136-43. 2008
    ..Lipid nanoemulsion of primaquine exhibited improved oral bioavailability and was taken up preferentially by the liver with drug concentration higher at least by 45% as compared with the plain drug...
  56. ncbi Single-molecule PCR using water-in-oil emulsion
    Michihiko Nakano
    Department of Ecological Engineering, Toyohashi University of Technology, Tempaku cho, Toyohashi, Aichi 441 8580, Japan
    J Biotechnol 102:117-24. 2003
    ..The W/O emulsion was broken and the second PCR step was carried out. This method can be easily applied to amplify a single DNA molecule...
  57. ncbi SolEmuls-novel technology for the formulation of i.v. emulsions with poorly soluble drugs
    R H Muller
    Department of Pharmaceutical Technology, Biotechnology and Quality Management, Free University Berlin, Kelchstrasse 31, 12169 Berlin, Germany
    Int J Pharm 269:293-302. 2004
    Intravenously injectable o/w emulsions of drugs being poorly soluble in water and simultaneously in oils need to be produced by locating the drug in the interfacial lecithin layer, e.g. amphotericin B...
  58. ncbi Novel cosmetic delivery systems: an application update
    V B Patravale
    Department of Pharmaceutical Sciences and Technology, University Institute of Chemical Technology, Mumbai 400 019, India
    Int J Cosmet Sci 30:19-33. 2008
    ..S. market alone for novel cosmetic delivery systems has been projected to be more than $41 billion for the year 2007. Novel cosmetic delivery systems reviewed here possess enormous potential as next-generation smarter carrier systems...
  59. ncbi Nanoemulsion improves the oral absorption of candesartan cilexetil in rats: Performance and mechanism
    Fang Gao
    Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
    J Control Release 149:168-74. 2011
    ..The overall results implicated that the nanoemulsion was very effective for enhancing the oral absorption of insoluble CC, and CCN showed the great potential for clinical application...
  60. pmc Mucosal immunization with a novel nanoemulsion-based recombinant anthrax protective antigen vaccine protects against Bacillus anthracis spore challenge
    Anna U Bielinska
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0648, USA
    Infect Immun 75:4020-9. 2007
    ..This potentially could lead to a needle-free anthrax vaccine requiring fewer doses and having fewer side effects than the currently available human vaccine...
  61. ncbi Comparison of stratum corneum penetration and localization of a lipophilic model drug applied in an o/w microemulsion and an amphiphilic cream
    Alexa Teichmann
    Department of Dermatology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Eur J Pharm Biopharm 67:699-706. 2007
    ..It was obvious that the microemulsion led to a penetration into the complete follicular infundibula, whereas, following application of the cream, a fluorescence signal was only received from the follicular orifices...
  62. ncbi Antimicrobial effects of a microemulsion and a nanoemulsion on enteric and other pathogens and biofilms
    Paula C Teixeira
    Escola Superior de Biotecnologia, R Dr Antonio Bernardino de Almeida, 4200 072 Porto, Portugal
    Int J Food Microbiol 118:15-9. 2007
    ..We examined the abilities of two fine emulsions, designated BCTP and TEOP, to inactivate suspensions of vegetative cells of Salmonella spp...
  63. ncbi Preparation and the in vitro evaluation of nanoemulsion system for the transdermal delivery of granisetron hydrochloride
    Wen wu Zheng
    Department of Cardiology, People s Hospital of Luzhou, No 61 Zhongxiao Road, Luzhou, Sichuan Province, P R China
    Chem Pharm Bull (Tokyo) 58:1015-9. 2010
    ....
  64. ncbi Bioavailability and delivery of nutraceuticals using nanotechnology
    Qingrong Huang
    Dept of Food Science, Rutgers Univ, New Brunswick, NJ 08901, USA
    J Food Sci 75:R50-7. 2010
    ..They are usually in the range 50 to 200 nm but much smaller than the range (from 1 to 100 mum) for conventional emulsions. Nanoemulsion preparation, characterization, and bioavailability have been discussed...
  65. ncbi Formulation, preparation and evaluation of an intravenous emulsion containing Brucea javanica oil and Coix Seed oil for anti-tumor application
    Ye Ling Yu
    Department of Pharmaceutics, Shenyang Pharmaceutical University, Wen Hua Road, No 103, Shenyang 110016, People s Republic of China
    Biol Pharm Bull 31:673-80. 2008
    ..The mortality study (BCOE 0, BJOE 63.3%, CSOE 13.3%) showed that BCOE greatly reduced the toxicity of BJOE and CSOE. Therefore, the development and application of BCOE will make an important contribution to anti-tumor therapy...
  66. ncbi Preparation of uniform-sized multiple emulsions and micro/nano particulates for drug delivery by membrane emulsification
    Wei Liu
    College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
    J Pharm Sci 100:75-93. 2011
    Much attention has in recent years been paid to fine applications of drug delivery systems, such as multiple emulsions, micro/nano solid lipid and polymer particles (spheres or capsules)...
  67. ncbi Food-grade nanoemulsions: formulation, fabrication, properties, performance, biological fate, and potential toxicity
    David Julian McClements
    Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA
    Crit Rev Food Sci Nutr 51:285-330. 2011
    ..particles in nanoemulsions (r<100 nm) means that they have a number of potential advantages over conventional emulsions-higher stability to droplet aggregation and gravitational separation, high optical clarity, ability to modulate ..
  68. ncbi Lipid nanoemulsions loaded with doxorubicin-oleic acid ionic complex: characterization, in vitro and in vivo studies
    Xuanmiao Zhang
    Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Sichuan, P R China
    Pharmazie 66:496-505. 2011
    ..Moreover, DOX-OA-LNs significantly decreased DOX concentration in heart, lung and kidney. These results suggested that DOX-OA-LNs could be a promising formulation for the delivery of DOX in tumor chemotherapy...
  69. ncbi The effect of a water/organic solvent interface on the structural stability of lysozyme
    M van de Weert
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, University Utrecht, Sorbonnelaan 16, 3584 CA, Utrecht, The Netherlands
    J Control Release 68:351-9. 2000
    ..b>Emulsions which contained poly(lactic-co-glycolic acid) (PLGA) in the organic phase gave irreproducible protein recovery...
  70. ncbi Microemulsions: a novel approach to enhanced drug delivery
    Sushama Talegaonkar
    Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, India
    Recent Pat Drug Deliv Formul 2:238-57. 2008
    ..also reflects the tremendous potential of these newer drug therapeutic systems. A critical evaluation of recent patents claiming different approaches to improve the drug delivery is the focus of the current review...
  71. ncbi Particle control of emulsion by membrane emulsification and its applications
    T Nakashima
    SPG Research Laboratory, Miyazaki Prefectural Industrial Technology Center, 16500 2 Higashi kaminaka, Sadowara, 880 0303, Miyazaki, Japan
    Adv Drug Deliv Rev 45:47-56. 2000
    Particle-size control of emulsion is very important for maintaining stability and giving emulsions new functional roles...
  72. ncbi The effect of temperature on di(2-ethylhexyl) phthalate leaching from PVC infusion sets exposed to lipid emulsions
    R J Rose
    Anaesthesia Research Group, Peninsula College of Medicine and Dentistry, University of Plymouth, Plymouth, UK
    Anaesthesia 67:514-20. 2012
    ..kg(-1) day(-1) if lipid based infusates are used for sedation or intravenous feeding of infants or neonates...
  73. ncbi Formulation and in vitro evaluation of a cosmetic emulsion from almond oil
    Naveed Akhtar
    Faculty of Pharmacy and Alternative Medicine, Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
    Pak J Pharm Sci 21:430-7. 2008
    Several processes are used for the manufacture of multiple emulsions. The most widely used procedure is two step method. 1st step consists of preparing a primary emulsion...
  74. ncbi Uniform amplification of phage display libraries in monodisperse emulsions
    Wadim L Matochko
    Department of Chemistry and Alberta Glycomics Centre for Carbohydrate Science, University of Alberta, Edmonton, Alberta, Canada T6G 2G2
    Methods 58:18-27. 2012
    ..We anticipate that this procedure can be easily adapted in any academic or industrial laboratory that uses phage display...
  75. ncbi Oxidative degradation and non-enzymatic browning due to the interaction between oxidised lipids and primary amine groups in different marine PL emulsions
    F S H Lu
    Division of Industrial Food Research, Technical University of Denmark, Søltofts Plads, Building 221, 2800 Kgs Lyngby, Denmark
    Food Chem 135:2887-96. 2012
    ..This study was undertaken to investigate both oxidative and hydrolytic stability of marine PL emulsions in relation to the chemical composition of the marine PL used...
  76. ncbi Influence of hydrophilic surfactants on the properties of multiple W/O/W emulsions
    T Schmidts
    Institute of Biopharmaceutical Technology, University of Applied Sciences Giessen Friedberg, Wiesenstr 14, 35390 Giessen, Germany
    J Colloid Interface Sci 338:184-92. 2009
    Multiple W/O/W emulsions for topical application using Span 80 as a lipophilic emulsifier were prepared. Several hydrophilic emulsifiers were tested in respect of their suitability for the preparation of multiple emulsions...
  77. ncbi Evaluation of novel nystatin nanoemulsion for skin candidosis infections
    F Fernández-Campos
    Biopharmaceutical and Pharmacokinetics Unit, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain
    Mycoses 56:70-81. 2013
    ..This antifungal effect was higher for nystatin loaded nanoemulsion than nystatin itself. A therapeutic improvement of the nystatin nanoemulsion treatment compared with the classical ones was achieved...
  78. ncbi Physicochemical characterization and in vivo evaluation of solid self-nanoemulsifying drug delivery system for oral administration of docetaxel
    Qizhe Quan
    College of Pharmacy, Yeungnam University, 214 1 Dae Dong, Gyongsan 712 749, South Korea
    J Microencapsul 30:307-14. 2013
    ..3% (w/v) docetaxel produced nanoemulsions, and showed about 12.5% absolute bioavailability in rats. Thus, this solid SNEDDS may be a potential candidate for oral pharmaceutical product with improved oral bioavailability of docetaxel...
  79. ncbi In vitro permeation studies of nanoemulsions containing ketoprofen as a model drug
    Beom Su Kim
    Laboratory of Enzyme Technology, College of Natural Science, Chonju, Republic of Korea
    Drug Deliv 15:465-9. 2008
    ..All ketoprofen-loaded nanoemulsions enhanced the in vitro permeation rate through mouse skins as compared to the control...
  80. ncbi Characterization and evaluation of self-microemulsifying sustained-release pellet formulation of puerarin for oral delivery
    Yi Zhang
    School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
    Int J Pharm 427:337-44. 2012
    ..7% compared with the tablet group. The results demonstrated that the puerarin-SMEDDS sustained-release pellets had a sustained-release effect, and could remarkably improve the oral bioavailability of puerarin...
  81. ncbi A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes
    Sangeeta Kashyap
    Diabetes Division, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284 3900, USA
    Diabetes 52:2461-74. 2003
    ....
  82. ncbi Ultrasound mediates the release of curcumin from microemulsions
    Mei Hwa Lee
    Department of Materials Science and Engineering, I Shou University, Kaohsiung 840, Taiwan
    Langmuir 24:1707-13. 2008
    ..Although cargo in microemulsions is partitioned, rather than encapsulated (as in, for example, liposomes), these new results demonstrate that microemulsion carriers are feasible for some ultrasonic drug delivery applications...
  83. ncbi Squalene emulsions for parenteral vaccine and drug delivery
    Christopher B Fox
    Infectious Disease Research Institute, Seattle, WA 98104, USA
    Molecules 14:3286-312. 2009
    Squalene is a linear triterpene that is extensively utilized as a principal component of parenteral emulsions for drug and vaccine delivery. In this review, the chemical structure and sources of squalene are presented...
  84. ncbi Emulsions containing partially water-miscible solvents for the preparation of drug nanosuspensions
    M Trotta
    Dipartimento di Scienza e Tecnologia del Farmaco, Universita degli Studi di Torino, Turin, Italy corrected
    J Control Release 76:119-28. 2001
    ..Because of the increase in available surface area, the dissolution rate of diaultrafiltrated suspensions increased greatly compared to commercial product...
  85. pmc Interaction of melittin peptides with perfluorocarbon nanoemulsion particles
    Sun Joo Lee
    Department of Biochemistry and Molecular Biophysics, Center for Computational Biology, Washington University in St Louis, St Louis, Missouri 63130, USA
    J Phys Chem B 115:15271-9. 2011
    ..These results suggest that melittin interacts with the monolayer of PFOB-NEP in a way that is similar way to its interaction with bilayers but that deeper penetration into the hydrophobic interior is inhibited...
  86. ncbi The protective effects of emulsified isoflurane on myocardial ischemia and reperfusion injury in rats
    Zhao Yang Hu
    Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People s Republic of China
    Can J Anaesth 56:115-25. 2009
    ..The purpose of this study was to examine the effect of emulsified isoflurane, a new formulation of isoflurane in lipid emulsion, administered intravenously in an ischemia and reperfusion model of myocardial injury...
  87. ncbi Optimization and in situ intestinal absorption of self-microemulsifying drug delivery system of oridonin
    Ying Liu
    School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 210203, PR China
    Int J Pharm 365:136-42. 2009
    ..Our results demonstrate CCD is of value in optimizing the SMEDDS formulation and understanding the effects of formulation compositions on SMEDDS properties...
  88. ncbi Development and evaluation of self-microemulsifying liquid and pellet formulations of curcumin, and absorption studies in rats
    Saipin Setthacheewakul
    Department of Pharmaceutical Technology, Prince of Songkla University, Songkhla, Thailand
    Eur J Pharm Biopharm 76:475-85. 2010
    ..These studies demonstrate that the new self-microemulsifying systems in liquid and pellet forms are promising strategies for the formulation of poorly soluble lipophilic compounds with low oral bioavailability...
  89. ncbi How to prepare and stabilize very small nanoemulsions
    Thomas Delmas
    CEA LETI, Campus MINATEC, Département des Technologies pour la Biologie et la Santé, 17 rue des Martyrs, F 38054 Grenoble, France
    Langmuir 27:1683-92. 2011
    ..However, as exemplified in the present work, nanoemulsion systems can present very long-term kinetic stability...
  90. ncbi Preparation and evaluation of self-nanoemulsified drug delivery systems (SNEDDSs) of matrine based on drug-phospholipid complex technique
    Jinghua Ruan
    Key Laboratory of Drug Targeting, Ministry of Education, Sichuan University, No 17, Section 3, Southern Renmin Road, Chengdu 610041, PR China
    Int J Pharm 386:282-90. 2010
    ..In conclusion, the absolute bioavailability of matrine drastically increased from 25% to 84.6% by the formation of MPC-SNEDDS, with an outstanding relative bioavailability of 338%, suggesting its great potential for clinical application...
  91. ncbi Effect of mannose density on mannose receptor-mediated cellular uptake of mannosylated O/W emulsions by macrophages
    Wassana Yeeprae
    Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Control Release 114:193-201. 2006
    Carbohydrate grafted emulsions are one of the most promising cell-specific targeting systems for lipophilic drugs...
  92. ncbi Nanoparticles by spray drying using innovative new technology: the Büchi nano spray dryer B-90
    Xiang Li
    Faculte de Pharmacie, UMR CNRS 7199 Laboratoire de Conception et Application de Molécules Bioactives, équipe de Pharmacie Biogalénique, Universite de Strasbourg, 74 route du Rhin BP 60024 F 67401 Illkirch Cedex, France
    J Control Release 147:304-10. 2010
    Spray drying technology is widely known and used to transform liquids (solutions, emulsions, suspension, slurries, pastes or even melts) into solid powders...
  93. ncbi Curcumin enhances oral bioavailability and anti-tumor therapeutic efficacy of paclitaxel upon administration in nanoemulsion formulation
    Srinivas Ganta
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, Massachusetts 02115, USA
    J Pharm Sci 99:4630-41. 2010
    ..The results of this study suggest that combination of PTX and CUR, administered in nanoemulsions, could improve oral bioavailability and therapeutic efficacy in ovarian adenocarcinoma...
  94. ncbi Nano-sized water-in-oil-in-water emulsion enhances intestinal absorption of calcein, a high solubility and low permeability compound
    Kenjiro Koga
    Department of Clinical Pharmaceutics, Hokuriku University, Kanazawa, Japan
    Eur J Pharm Biopharm 74:223-32. 2010
    Our goal was to develop safe and stable multilayer emulsions capable of enhancing intestinal absorption of biopharmaceutics classification system (BCS) class III drugs...
  95. ncbi Enhancement of stability and skin permeation by sucrose stearate and cyclodextrins in progesterone nanoemulsions
    Victoria Klang
    University of Vienna, Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Life Sciences, Althanstrasse 14, 1090 Vienna, Austria
    Int J Pharm 393:152-60. 2010
    ....
  96. ncbi Self-nanoemulsifying drug delivery systems of tamoxifen citrate: design and optimization
    Yosra S R Elnaggar
    Department of Pharmaceutics, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt yosra
    Int J Pharm 380:133-41. 2009
    ..Realizing drug incorporation into an optimized nano-sized SNEDD system that encompasses a bioactive surfactant, our results proposed that the prepared system could be promising to improve oral efficacy of the tamoxifen citrate...
  97. ncbi Drug delivery strategies for poorly water-soluble drugs
    Alfred Fahr
    Friedrich Schiller Universitat Jena, Institute for Pharmacy, Lessingstrasse 8, D 07743 Jena, Germany
    Expert Opin Drug Deliv 4:403-16. 2007
    ..This article addresses the emerging formulation designs for delivering of poorly water-soluble drugs...
  98. ncbi Oral microemulsions of paclitaxel: in situ and pharmacokinetic studies
    Adwoa O Nornoo
    Department of Pharmaceutical Sciences, Albany College of Pharmacy, Albany, NY 12208 3492, USA
    Eur J Pharm Biopharm 71:310-7. 2009
    ..The area-under-the-curve of PAC in CM was significantly larger than LBM, CPM and CE. Oral microemulsions of PAC were developed that increased both the permeability and AUC of PAC as compared to CE...
  99. ncbi Preparing polymer-based sustained-release systems without exposing proteins to water-oil or water-air interfaces and cross-linking reagents
    Tuo Jin
    Shanghai JiaoTong University School of Pharmacy, China
    J Control Release 128:50-9. 2008
    ....
  100. ncbi Design of fenofibrate microemulsion for improved bioavailability
    LianDong Hu
    School of Pharmaceutical Sciences, Hebei University, Baoding 071002, China
    Int J Pharm 420:251-5. 2011
    ..63 and 1.30-fold higher than that of the capsule. Our results indicated that the microemulsions could be used as an effective formulation for enhancing the oral bioavailability of fenofibrate...
  101. ncbi Bioavailability of probucol from lipid and surfactant based formulations in minipigs: influence of droplet size and dietary state
    Flemming Seier Nielsen
    Department of Pharmaceutics, The Danish University of Pharmaceutical Sciences, Copenhagen, Denmark
    Eur J Pharm Biopharm 69:553-62. 2008
    ..Comparing the absorption in fasted and fed minipigs showed that probucol exhibited no significant food effect, when formulated in a lipid and surfactant based formulations...

Research Grants64

  1. Long Chain Fatty Acid (LCFA) Taste Receptor CD36 in Food Choice and Consumption
    Eric Walters; Fiscal Year: 2007
    ..We will evaluate simple oil/water emulsions, dairy, and soy milk based beverages so that we can present palatable samples which will not provide olfactory ..
  2. Sub-micrometer zero valent metal for in-situ remediation of contaminated aquifers
    JOHN FREIM; Fiscal Year: 2007
    ..The Phase I work will conclude by making zero valent metal-containing water in oil emulsions that can accomplish the in-situ remediation of non aqueous phase contaminants...
  3. Cholestasis Reversal (Phase ll): Efficacy of lV Fish Oil
    Mark Puder; Fiscal Year: 2010
    ..Studies suggest that soybean oil containing intravenous fat emulsions (IFE) may be a major contributing factor...
  4. Nanoemulsion-based vaccine for chronic hepatitis B virus
    James R Baker; Fiscal Year: 2010
    ..Nanoemulsion adjuvants are oil-in-water emulsions prepared by high speed homogenization using innocuous surfactants and solvents as stabilizers with an average ..
  5. Biomimetic Approach to the Fabrication of Red Blood Cell Mimics
    Joseph M DeSimone; Fiscal Year: 2010
    ..Previous approaches for the design of synthetic blood have focused on i) fluorocarbon emulsions which can dissolve large amounts of blood gases;ii) PEGylated hemoglobin;and iii) liposomal delivery of ..
  6. Regulation of Hepatic Metabolic Function by Parenteral Nutrition
    Douglas G Burrin; Fiscal Year: 2013
    ..Aim 2 will test whether phytosterols present in parenteral soybean-lipid emulsions induce cholestasis and metabolic liver disease via antagonism of FXR receptor function...
  7. Oral prodrug of a novel antiviral that blocks neuronal reactivation of HSV
    George E Wright; Fiscal Year: 2012
    ..formulate the pro-drug Sacrovir (6-deoxy-mCF3PG) to enhance its intestinal absorption;strategies include emulsions, small molecule adjuvants, and solubility enhancers;2...
  8. Antibacterial, antifungal, antiviral, and antispore paints
    YUYU contact SUN; Fiscal Year: 2011
    ..tetramethyl-4-piperidinyl acrylate (Cl-TMPA), will be polymerized to produce polymeric N-halamine latex emulsions. On adding a small amount of such emulsions into conventional water-based latex paint, the new paint will be ..
  9. The Role of GPR120 and Omega-3 Fatty Acids in Steatosis and Systemic Inflammation
    Sarah Carlson; Fiscal Year: 2013
    ..Commonly used lipid emulsions are rich in soybean oil, which contain large quantities of pro-inflammatory omega-6 fatty acids and hepatotoxic ..
  10. PHYSIOLOGY OF FLUOROCARBON OXYGEN TRANSPORT
    LELAND CLARK; Fiscal Year: 1992
    New high capacity fluorocarbon emulsions will be tested for their ability to increase brain oxygen availability. The emulsions will be administered intravenously to rabbits having implanted oxygen, hydrogen, glucose, and lactate sensors...
  11. Rational Design of Lipidic Vectors for Mitochondria-Targeted Antioxidants
    Song Li; Fiscal Year: 2013
    ..the insufficiently hydrophobic agents with the highly lipophilic aliphatic chains in surfactants and oil core of emulsions. Drugs that are initially mixed with oil core tend to slowly move to the interface of emulsion particles and ..
  12. Neural Mechansims of Oil Reward
    Ralph Norgren; Fiscal Year: 2010
    ..The experiments of Aim 1 will examine the ability of oils and oil/water emulsions to stimulate individual tactile, taste, and thermal fibers of the gustatory and somatosensory nerves that ..
  13. Droplet Method for Bilayer Assays
    Gregory W Faris; Fiscal Year: 2010
    ..investigate the inverted emulsion method for membrane proteins by: (1) studying bilayer formation in an inverted emulsions by characterizing the bilayer performance with respect to the continuous phase and lipid composition and phase ..
  14. Nanocarriers for Vaccine Delivery
    John D Clements; Fiscal Year: 2013
    ..been developed that may be appropriate for vaccine delivery, including liposomes, micro-, nano-, and multiple-emulsions, polymeric nano- particles, dendrimers, and immunostimulatory complexes (ISCOMS)...
  15. Osteogenic Calcium Phosphate Nanoparticles with Designable Drug Release Kinetics
    Vuk Uskoković; Fiscal Year: 2012
    ..and osteoinductive calcium phosphate nanoparticles by means of co-precipitation from ultrasonically agitated emulsions;b) Drug release studies in bacterial and cell cultures...
  16. Technology Development for Recombinant Affinity Reagents
    BRIAN KENNETH KAY; Fiscal Year: 2013
    ..Second, we plan to improve our current selection protocols by using emulsions to make them faster, smaller, cheaper, and better...
  17. Early Events in Lipoprotein Assembly
    CHRISTOPHER JAMES MCKNIGHT; Fiscal Year: 2010
    ..fragments of ApoS in a cell free system supplemented with phospholipids and phospholipid-triacylglycerol emulsions to test the hypothesis that cotranslational interaction of ApoS with lipids is spontaneous and essential for the ..
  18. Novel emulsion-based formulation of the anti-glaucoma MSH-1001 for improved topic
    Ronald A Wassel; Fiscal Year: 2011
    ..2) Take the three most promising emulsions that meet all of our criteria (i.e...
  19. Effect of antimicrobial nanoemulsions on oral biofilms
    Valerie A Lee; Fiscal Year: 2012
    ..Nanoemulsions are surfactant-containing oil-in-water emulsions (droplet size 400-800 nm) that are non-toxic to animals but very effective against bacteria, fungi, viruses and ..
  20. ORAL DRUG DELIVERY AND BIOAVAILABILITY--AIDS
    Gordon Amidon; Fiscal Year: 1993
    ..and furosemide or nadolol; (2) extend the transport model for drug dissolution into surfactant solutions to emulsions and apply this model to estimating the extend of drug absorption for water insoluble drugs in humans; (3) ..
  21. Spindle Assembly and Scaling via Microfluidic Encapsulation of Xenopus Nuclei
    JOHN S OAKEY; Fiscal Year: 2012
    ..To analyze the relationship between cytoplasmic volume and spindle size using well-defined extract-mineral oil emulsions, and 2) To develop and apply a high-throughput microfluidic-based approach to regulate spindle:droplet ratio and ..
  22. DEVELOPMENT OF PICKERING EMULSIONS AS INJECTABLE BONE GRAFTS
    ELIZABETH MARIE COSGRIFF-HERNANDEZ; Fiscal Year: 2013
    ....
  23. Molecular Mechanisms of Dietary Fat Digestion by Pancreatic Lipases
    Mark E Lowe; Fiscal Year: 2012
    ..identified critical residues in PTL-colipase and PLRP2 that influence the absorption of these lipases to lipid emulsions. 3) Comparison and preliminary analysis of the structures of PTL and PLRP2 identified domains that can mediate ..
  24. Effect of Physicochemical Properties of Ophthalmic Formulations on Ocular Bioavai
    Uday B Kompella; Fiscal Year: 2012
    ..Unlike solutions, ophthalmic suspensions/emulsions require an additional step of "dissolution or "release" before the drug is absorbed from the dosage form...
  25. In Vivo Cellular and Molecular Imaging Centers (ICMICs)
    David R Vera; Fiscal Year: 2012
    ..They plan to take advantage of the fact that fluorocarbon emulsions are visible only when combined to induce aggregation at the time the emulsion is exposed to the enzyme of ..
  26. Cholestasis Prevention: Efficacy of IV Fish Oil
    Mark Puder; Fiscal Year: 2009
    ..Studies suggest that soybean oil containing intravenous fat emulsions (IFE) may be a major contributing factor...
  27. RADIOPAQUE FLUOROCARBON IN DIAGNOSTIC RADIOLOGY
    David Long; Fiscal Year: 1980
    ..Experiments with RFC in lymphography have been completed and humans studies will be started soon. Emulsions of RFC have been perfected so that large quantities can be given safely intravenously...
  28. Reduced Temperature Thermal Ablation for HCC and other Liver Tumors
    MICHAEL JUDE BORRELLI; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Cyclopentadecanolide (CPDL) emulsions markedly lower the threshold temperature required to thermally ablate solid tissues...
  29. APOE3 AND APOE4 EFFECTS ON CELLULAR PATHOBIOLOGY
    ROBERT PITAS; Fiscal Year: 1999
    ..Only apoE added to the cell with beta- migrating very low density lipoproteins (beta-VLDL) or lipid emulsions had an effect, and the effect was blocked by reductive methylation of apoE or by antibodies to the receptor-..
  30. PHOSPHORIMAGER
    Allan Brasier; Fiscal Year: 1993
    ..Even under optimized conditions to enhance sensitivity of detection by film emulsions, X-ray film demonstrates a narrow range of linear response...
  31. Parenteral Medium Chain Triglycerides in the Premature
    Eberhard Schmidt Sommerfeld; Fiscal Year: 2002
    ..MCT-containing lipid emulsions are being studied in adults. No studies in premature infants have been reported in the U.S...
  32. Genetic circuits based on allosteric ribozymes
    Andrew D Ellington; Fiscal Year: 2010
    ..reactions using a novel trans-selection method based on in vitro compartmentalization (IVC) in water-in-oil emulsions. The fastest aptazymes will then be further screened for function in E. coli cells...
  33. Development and Production of Parenteral Dosage Forms for Clinical Studies
    Timothy Smith; Fiscal Year: 2011
    ..e. large volume parenterals, sterile emulsions, liposomes and sterile micro-dispersions) is desirable but not essential...
  34. Development and Production of Parenteral Dosage Forms for Clinical Studies
    Timothy Smith; Fiscal Year: 2010
    ..e. large volume parenterals, sterile emulsions, liposomes and sterile micro-dispersions) is desirable but not essential...
  35. Development and Production of Parenteral Dosage Forms for Clinical Studies
    Timothy Smith; Fiscal Year: 2009
    ..e. large volume parenterals, sterile emulsions, liposomes and sterile micro-dispersions) is desirable but not essential...
  36. FLUORESCENT AMINO ACID PROBE OF TEMPLATE-STRAND BASES
    WAYNE MORRIS BARNES; Fiscal Year: 2012
    ..of our idea works, it could be relatively inexpensive, since no machined chips, no unusual dNTPs, and no PCR emulsions need be involved. (but would be allowed)...
  37. T CELL IMMUNITY AND SYNTHETIC PEPTIDE AIDS VACCINES
    Amnon Altman; Fiscal Year: 1991
    ..coli as immunological adjuvants that can bypass the need for oil emulsions and other unacceptable adjuvants...
  38. LIPOPROTEIN LIPASE MODULATION OF TISSUE LIPID UPTAKE
    JOSEPH OBUNIKE; Fiscal Year: 1999
    ..Studies which I performed showed that LPL increased uptake of low density lipoprotein (LDL) and lipid-emulsions by fibroblasts and THP-1 macrophages...
  39. Massively Parallel Haplotyping
    David Scott Johnson; Fiscal Year: 2012
    ..nucleotide polymorphisms (SNPs) by intermolecular hybridization, and then sequences linked loci in reversed emulsions by next-generation sequencing...
  40. SUPERHEATED DROP DETECTORS FOR DOSIMETRY IN RADIOTHERAPY
    Ravinder Nath; Fiscal Year: 2001
    ..Specifically, we propose: (1) to improve the photon energy response of the SEC by using emulsions containing only elements with tissue-like atomic numbers; (2) to optimize the speed of image acquisition and ..
  41. MARINE LIPIDS AND ENDOTHELIAL CELLS IN ATHEROSCLEROSIS
    Paul Fox; Fiscal Year: 1992
    ..factor production by cultured EC is regulatable and, as we have recently observed, is inhibited by fish oil emulsions and certain modified lipoproteins...
  42. A Multicomponent Anthrax Vaccine using Phage T4 Display
    VENIGALLA RAO; Fiscal Year: 2007
    ..of proteins on the surface of T4, and the other with broad experience with TCI, immunogenic liposomes, emulsions, vaccine formulations, and vaccine clinical trials, in close collaboration with a third laboratory that is a ..
  43. AN IVEM FOR HIGH RESOLUTION ELECTRONS CRYO-MICROSCOPY
    CHRISTOPHER AKEY; Fiscal Year: 2000
    ..complexes (GM1-cholera toxin & insulin receptor- insulin), h) studies of isolated rafts of Apo B, lipid emulsions and lipid phases during bile formation and i) morphological analysis of distinct amyloid fibrils formed by ..
  44. STRUCTURAL/FUNCTIONAL PROPERTIES OF HUMAN LIPOPROTEIN A
    Joel Morrisett; Fiscal Year: 1992
    ..aim is to reconstitute solubilized apo(a) and apoB separately and together into phospholipid/neutral lipid micro-emulsions and to assess the effect of each apoprotein on the secondary structure, tertiary structure, and cell receptor ..
  45. Parenteral Formulations for Synthetic Retinoids
    Ralph Parchment; Fiscal Year: 2001
    ..The Pharmacology Core at Wayne State University found that novel co-polymer mixtures or lipid emulsions may be suitable IV carriers for fenretinide that may be useful to exceed the apparent saturable absorption ..
  46. PCC+ CHROMOSOME PAINTING IN RADIATION AND DRUG STUDIES
    John Brown; Fiscal Year: 1999
    ..e., tirapazamine, carbogen with nicotinamide, recombinant human erythropoietin, fluorocarbon emulsions, such as perflubron and others )...
  47. MEROCYANINE PHOTOPRODUCTS WITH ANTINEOPLASTIC ACTIVITY
    Fritz Sieber; Fiscal Year: 2003
    ..Merocyanine 540 (MC540) is a polymethine dye that was originally developed as a sensitizing agent for photographic emulsions. We and others have subsequently shown that MC540 is also an effective and versatile agent for the extracorporal ..
  48. FIELD-FLOW FRACTIONATION IN BIOCHEMICAL ANALYSIS
    Karin Caldwell; Fiscal Year: 1992
    ..This mode of operation will be studied to enable the accurate characterization of spherical viruses, emulsions and liposomes...
  49. METABOLIC STUDIES OF PARENTERAL NUTRITION IN INFANTS
    RALPH DELL; Fiscal Year: 1980
    ..The second subproject concerns the metabolism of intravenously-administered fat emulsions. The objective of the third subproject is to define the parenteral requirement for all amino acids...
  50. NOVEL CLASS OF FLUOROCARBONS AS BLOOD SUBSTITUTES
    Gordhan Patel; Fiscal Year: 1990
    ..The proposed compositions will be synthesized, purified, and characterized. Emulsions and other preparations will be prepared and their ability to dissolve oxygen will be determined...
  51. EXAMINATION OF PERFUSION OF THE HEART BY 19F NMR
    Craig Malloy; Fiscal Year: 1990
    ..Preliminary results indicate that perfluorocarbon emulsions have potential as imaging agents delineating for the "bed-at-risk" and indicators of the severity of ischemic ..
  52. EFFECT OF IV INFUSIONS ON ENERGY BALANCE
    HENRY KOOPMANS; Fiscal Year: 1990
    ..specific aim is to assess the effect of intravenous infusions of glucose and amino acids and of medical fat emulsions on voluntary food intake and metabolic rate...
  53. STRUCTURED LIPIDS IN CATABOLIC STATES
    Bruce Bistrian; Fiscal Year: 1993
    ..However conventional long chain triglyceride emulsions are less well tolerated by severely injured patients...
  54. DEVELOPMENT AND PRODUCTION OF PARENTERAL DOSAGE FORMS
    Timothy Smith; Fiscal Year: 2000
    ..The capability to develop and manufacture other pharmaceutical dosage form (i.e. large volume parental, sterile emulsions, sterile micro-dispersions, etc) is desirable but not essential...
  55. RADIOPAQUE FLUOROCARBON IN DIAGNOSTIC RADIOLOGY
    David Long; Fiscal Year: 1991
    ..The pharmacodynamics of concentrated emulsions of perfluorooctylbromide (PFOB) will be determined by measuring the distribution, metabolism and elimination ..
  56. Direct Conversion Dental Sensor
    Paul Bennett; Fiscal Year: 2005
    ..have all the advantages of a digital technology and retain the most desirable aspects of image quality that film emulsions provide...
  57. EFFECTS OF RADIOSENSITIZERS MEASURED BY MRI
    Gregory Karczmar; Fiscal Year: 2001
    ..Perfluorocarbon emulsions (PFCs) will be injected I.V. or intratumorally and taken up into tumors over a period of days...
  58. Pharmacokinetic strategies to optimize IP chemotherapy
    JOSEPH BALTHASAR; Fiscal Year: 2009
    ..g., anti-drug antibodies, lipid emulsions) to impart regio-selective alterations in drug disposition, thereby enhancing the therapeutic selectivity of ..
  59. Polymerases for Sequencing by Synthesis
    Steven Benner; Fiscal Year: 2007
    ..triphosphates that have fluorescent blocking groups; (b) use directed evolution system in water-in-oil emulsions to select polymerases that accept the triphosphates efficiently and faithfully; (c) obtain polymerases to ..
  60. Predoctoral Fellowship for Students with Disabilities
    William Holland; Fiscal Year: 2007
    ..Intravenous infusion of saturated and unsaturated lipid emulsions and administration of high fat diets will be used to promote elevations in serum free fatty acids...
  61. Neuropharmacology of Learned Food Preferences
    Anthony Sclafani; Fiscal Year: 2009
    ..It will advance our understanding of the basic mechanisms involved in the development of food preferences and may provide insights into the clinical treatment of overeating and obesity. ..
  62. Chemotherapy with injectable microdroplets
    FRANCESCO D ERRICO; Fiscal Year: 2007
    ..the usefulness of a novel drug delivery technology for cancer treatment, based on intravenously injectable emulsions of superheated perfluorocarbon droplets loaded with a therapeutic agent...