emulsions

Summary

Summary: Colloids of two immiscible liquids where either phase may be either fatty or aqueous; lipid-in-water emulsions are usually liquid, like milk or lotion and water-in-lipid emulsions tend to be creams.

Top Publications

  1. ncbi Exemestane loaded self-microemulsifying drug delivery system (SMEDDS): development and optimization
    Ajeet K Singh
    Dabur Research Foundation, Plot No 22, Site IV, Sahibabad, Ghaziabad, Uttar Pradesh 201010, India
    AAPS PharmSciTech 9:628-34. 2008
  2. ncbi Preparation, characterization and optimization of probucol self-emulsified drug delivery system to enhance solubility and dissolution
    A Zaghloul
    Department of Pharmaceutics, Faculty of Pharmacy, Kuwait University, Safat, Kuwait
    Pharmazie 63:654-60. 2008
  3. ncbi Transdermal delivery of hydrocortisone from eucalyptus oil microemulsion: effects of cosurfactants
    Gamal M El Maghraby
    Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, P O Box 2457, Saudi Arabia
    Int J Pharm 355:285-92. 2008
  4. ncbi The effect of lidocaine on the globule size distribution of propofol emulsions
    Jong Woo Park
    Department of Pharmaceutics, College of Pharmacy, Sungkyunkwan University, Suwon, South Korea
    Anesth Analg 97:769-71. 2003
  5. ncbi Preparation and in vivo evaluation of SMEDDS (self-microemulsifying drug delivery system) containing fenofibrate
    Ashok R Patel
    Centre for Novel Drug Delivery Systems, Department of Pharmaceutical Sciences, University Institute of Chemical Technology, Matunga, Mumbai, India
    AAPS J 9:E344-52. 2007
  6. ncbi Cremophor-free intravenous microemulsions for paclitaxel II. Stability, in vitro release and pharmacokinetics
    Adwoa O Nornoo
    Department of Pharmaceutical Sciences, Albany College of Pharmacy, Albany, NY 12208, USA
    Int J Pharm 349:117-23. 2008
  7. ncbi Microemulsions: an overview and pharmaceutical applications
    S Tenjarla
    Serquest, a Southern Research Institute Company, Birmingham, AL 35205, USA
    Crit Rev Ther Drug Carrier Syst 16:461-521. 1999
  8. ncbi Microemulsion formulation for enhanced absorption of poorly soluble drugs. II. In vivo study
    Kohsaku Kawakami
    Developmental Research Laboratories, Shionogi and Co, Ltd, 12 4 Sagisu 5 chome, Fukushima ku, 553 0002, Osaka, Japan
    J Control Release 81:75-82. 2002
  9. ncbi Pre-clinical evaluation of a novel nanoemulsion-based hepatitis B mucosal vaccine
    Paul E Makidon
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 3:e2954. 2008
  10. ncbi Docetaxel microemulsion for enhanced oral bioavailability: preparation and in vitro and in vivo evaluation
    Yong Mei Yin
    College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
    J Control Release 140:86-94. 2009

Research Grants

  1. Long Chain Fatty Acid (LCFA) Taste Receptor CD36 in Food Choice and Consumption
    Eric Walters; Fiscal Year: 2007
  2. Sub-micrometer zero valent metal for in-situ remediation of contaminated aquifers
    JOHN FREIM; Fiscal Year: 2007
  3. METABOLISM OF INTRAVENOUS LIPID EMULSIONS
    Richard Deckelbaum; Fiscal Year: 2007
  4. Cholestasis Reversal (Phase ll): Efficacy of lV Fish Oil
    Mark Puder; Fiscal Year: 2010
  5. Antibacterial, antifungal, antiviral, and antispore paints
    YUYU contact SUN; Fiscal Year: 2010
  6. Molecular Mechanisms of Dietary Fat Digestion by Pancreatic Lipases
    Mark E Lowe; Fiscal Year: 2010
  7. Molecular Mechanisms of Dietary Fat Digestion by Pancreatic Lipases
    Mark Lowe; Fiscal Year: 2009
  8. Cholestasis Prevention: Efficacy of IV Fish Oil
    Mark Puder; Fiscal Year: 2009
  9. Genetic circuits based on allosteric ribozymes
    Andrew Ellington; Fiscal Year: 2007
  10. Genetic circuits based on allosteric ribozymes
    Andrew D Ellington; Fiscal Year: 2010

Detail Information

Publications225 found, 100 shown here

  1. ncbi Exemestane loaded self-microemulsifying drug delivery system (SMEDDS): development and optimization
    Ajeet K Singh
    Dabur Research Foundation, Plot No 22, Site IV, Sahibabad, Ghaziabad, Uttar Pradesh 201010, India
    AAPS PharmSciTech 9:628-34. 2008
    ..Thus this study indicates that the SMEDDS can be used as a potential drug carrier for dissolution enhancement of exemestane and other lipophilic drug(s)...
  2. ncbi Preparation, characterization and optimization of probucol self-emulsified drug delivery system to enhance solubility and dissolution
    A Zaghloul
    Department of Pharmaceutics, Faculty of Pharmacy, Kuwait University, Safat, Kuwait
    Pharmazie 63:654-60. 2008
    ..The experimental design applied helped in understanding the effects and the interaction effects between the independent factors. The prepared PBSEDDS may have the potential to enhance the therapeutic bioavailability of probucol...
  3. ncbi Transdermal delivery of hydrocortisone from eucalyptus oil microemulsion: effects of cosurfactants
    Gamal M El Maghraby
    Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, P O Box 2457, Saudi Arabia
    Int J Pharm 355:285-92. 2008
    ..Ethanol produced the greatest effect followed by propylene glycol and isopropanol. The presence of cosurfactant and its type can thus affect both the phase behavior and the transdermal delivery potential of microemulsion...
  4. ncbi The effect of lidocaine on the globule size distribution of propofol emulsions
    Jong Woo Park
    Department of Pharmaceutics, College of Pharmacy, Sungkyunkwan University, Suwon, South Korea
    Anesth Analg 97:769-71. 2003
    ..Its increase was minimized by the addition of L-lysine to the propofol emulsion...
  5. ncbi Preparation and in vivo evaluation of SMEDDS (self-microemulsifying drug delivery system) containing fenofibrate
    Ashok R Patel
    Centre for Novel Drug Delivery Systems, Department of Pharmaceutical Sciences, University Institute of Chemical Technology, Matunga, Mumbai, India
    AAPS J 9:E344-52. 2007
    ..Thus, the study confirmed that the SMEDDS formulation can be used as a possible alternative to traditional oral formulations of fenofibrate to improve its bioavailability...
  6. ncbi Cremophor-free intravenous microemulsions for paclitaxel II. Stability, in vitro release and pharmacokinetics
    Adwoa O Nornoo
    Department of Pharmaceutical Sciences, Albany College of Pharmacy, Albany, NY 12208, USA
    Int J Pharm 349:117-23. 2008
    ....
  7. ncbi Microemulsions: an overview and pharmaceutical applications
    S Tenjarla
    Serquest, a Southern Research Institute Company, Birmingham, AL 35205, USA
    Crit Rev Ther Drug Carrier Syst 16:461-521. 1999
    ..Several references are cited, but the list is by no means exhaustive. The review is written so that a newcomer to the field can easily grasp the important facts pertaining to this novel delivery system...
  8. ncbi Microemulsion formulation for enhanced absorption of poorly soluble drugs. II. In vivo study
    Kohsaku Kawakami
    Developmental Research Laboratories, Shionogi and Co, Ltd, 12 4 Sagisu 5 chome, Fukushima ku, 553 0002, Osaka, Japan
    J Control Release 81:75-82. 2002
    ..HCO-60 and Tween 80-based formulations were mild to the organs, while BL-9EX-based formulation caused serious damage. The behavior and absorption mechanism of the microemulsion formulations are discussed...
  9. ncbi Pre-clinical evaluation of a novel nanoemulsion-based hepatitis B mucosal vaccine
    Paul E Makidon
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 3:e2954. 2008
    ..A new nasal hepatitis B vaccine composed of recombinant hepatitis B surface antigen (HBsAg) in a novel nanoemulsion (NE) adjuvant (HBsAg-NE) could be effective with fewer administrations...
  10. ncbi Docetaxel microemulsion for enhanced oral bioavailability: preparation and in vitro and in vivo evaluation
    Yong Mei Yin
    College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
    J Control Release 140:86-94. 2009
    ..These results encourage further development of docetaxel microemulsions as an oral drug delivery system...
  11. ncbi Enhanced humoral and Type 1 cellular immune responses with Fluzone adjuvanted with a synthetic TLR4 agonist formulated in an emulsion
    Susan L Baldwin
    Infectious Disease Research Institute, 1124 Columbia Street, Suite 400, Seattle, WA 98104, United States
    Vaccine 27:5956-63. 2009
    ....
  12. ncbi Microemulsion-based media as novel drug delivery systems
    M J Lawrence
    Department of Pharmacy, King s College London, Franklin Wilkins Building, 150 Stamford Street, SE1 9NN, London, UK
    Adv Drug Deliv Rev 45:89-121. 2000
    ..The use of microemulsions and closely related microemulsion-based systems as drug delivery vehicles is reviewed, with particular emphasis being placed on recent developments and future directions...
  13. ncbi Optical properties of fat emulsions
    Rene Michels
    Institut fur Lasertechnologien in der Medizin und Messtechnik, Helmholtzstr 12, D 89081 Ulm, Germany
    Opt Express 16:5907-25. 2008
    We present measurements of the optical properties of six different fat emulsions from three different brands, Clinoleic, Lipovenoes and Intralipid, with fat concentrations from 10% to 30%...
  14. ncbi Solid lipid nanoparticles for enhancing vinpocetine's oral bioavailability
    Yifan Luo
    School of Pharmacy, Department of Pharmaceutics, Mailbox 42, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016 Liaoning, P.R. China
    J Control Release 114:53-9. 2006
    ..These results indicated that VIN absorption is enhanced significantly by employing SLN formulations. SLNs offer a new approach to improve the oral bioavailability of poorly soluble drugs...
  15. ncbi Microemulsions for topical delivery of estradiol
    S Peltola
    Department of Pharmaceutics, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    Int J Pharm 254:99-107. 2003
    ..extensive first pass metabolism after oral administration, transdermal administration of estradiol in gels and emulsions has been used to improve its bioavailability, prolong activity and to optimize metabolic profile...
  16. ncbi Paclitaxel associated with cholesterol-rich nanoemulsions promotes atherosclerosis regression in the rabbit
    Raul C Maranhão
    Heart Institute of the Medical School Hospital InCor, University of Sao Paulo, Sao Paulo, Brazil
    Atherosclerosis 197:959-66. 2008
    ..LDE-paclitaxel treatment had no toxicity. In conclusion, LDE-paclitaxel produced pronounced atherosclerosis regression without toxicity and has shown remarkable potential in cardiovascular therapeutics...
  17. ncbi The effect of oil components on the physicochemical properties and drug delivery of emulsions: tocol emulsion versus lipid emulsion
    Chi Feng Hung
    School of Medicine, Fu Jen Catholic University, Taipei, Taiwan
    Int J Pharm 335:193-202. 2007
    ..The inclusion of resveratrol into the emulsions and aqueous micelles retarded the drug release...
  18. ncbi Enhancement of transdermal delivery of theophylline using microemulsion vehicle
    X Zhao
    Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210038, PR China
    Int J Pharm 327:58-64. 2006
    ..65-fold higher than that of oral solution administration. These studies showed that microemulsion system of theophylline might be promising vehicles for the transdermal delivery of theophylline...
  19. ncbi Intestinal lymphatic transport of halofantrine occurs after oral administration of a unit-dose lipid-based formulation to fasted dogs
    Shui-Mei Khoo
    Department of Pharmaceutics, Victorian College of Pharmacy, Monash University, Parkville, Victoria 3052, Australia
    Pharm Res 20:1460-5. 2003
    ..Furthermore, microemulsions based on long-chain glycerides appear to be more effective with respect to lymphatic transport than the equivalent medium-chain formulation...
  20. ncbi Cetyl palmitate-based NLC for topical delivery of Coenzyme Q(10) - development, physicochemical characterization and in vitro release studies
    Veerawat Teeranachaideekul
    Department of Pharmacy, Mahidol University, Bangkok, Thailand
    Eur J Pharm Biopharm 67:141-8. 2007
    ..The NLC release patterns were defined by an initial fast release in comparison to the release of NE followed by a prolonged release, which was dependent on the oil content...
  21. ncbi Enhancing intestinal drug solubilisation using lipid-based delivery systems
    Christopher J H Porter
    Department of Pharmaceutics, Victorian College of Pharmacy, Monash University Parkville Campus, Parkville, Victoria 3052, Australia
    Adv Drug Deliv Rev 60:673-91. 2008
    ..Finally, a series of seven guiding principles for formulation design of lipid-based delivery systems are suggested based on an analysis of recent data generated in our laboratories and elsewhere...
  22. ncbi Investigation of microemulsion system for transdermal delivery of meloxicam
    Yue Yuan
    Laboratory of Drug Metabolism and Pharmacokinetics, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, People's Republic of China
    Int J Pharm 321:117-23. 2006
    ..The optimum formulation with the highest skin permeation rate (5.40 microg/cm2/h) consisted of 0.375% meloxicam, 5% IPM, 50% Tween 85/ethanol (1:1) and water...
  23. ncbi A study of microemulsion systems for transdermal delivery of triptolide
    Huabing Chen
    Institute of Materia Medica, College of Life Science and Technology, Huazhong University of Science and Technology, 430074 Wuhan, China
    J Control Release 98:427-36. 2004
    ..025% triptolide revealed the significant skin irritation. The results indicate that the studied microemulsion systems, especially ME6, may be promising vehicles for the transdermal delivery of triptolide...
  24. ncbi The novel formulation design of O/W microemulsion for improving the gastrointestinal absorption of poorly water soluble compounds
    Hiroshi Araya
    Formulation Technology Research Department, Pharmaceutical Technology Division, Chugai Pharmaceutical Co Ltd, 5 1, Ukima 5 chome, Kita ku, Tokyo 115 8543, Japan
    Int J Pharm 305:61-74. 2005
    ..Accordingly, this novel O/W microemulsion is a useful formulation, which enhances the oral bioavailability by raising the solubility of poorly water soluble compounds...
  25. ncbi The effect of internal structure of selected water-Tween 40-Imwitor 308-IPM microemulsions on ketoprofene release
    F Podlogar
    University of Ljubljana, Faculty of Pharmacy, 1000 Ljubljana, Askerceva 7, SI, Slovenia
    Int J Pharm 302:68-77. 2005
    ..Combining different methods to obtain the physical and structural properties of microemulsions can be thus used to predict the release of ketoprofen from a microemulsion...
  26. ncbi Effect of self-microemulsifying drug delivery systems containing Labrasol on tight junctions in Caco-2 cells
    Xianyi Sha
    Department of Pharmaceutics, School of Pharmacy, Fudan University, No 138 Yixueyuan Road, Shanghai 200032, China
    Eur J Pharm Sci 24:477-86. 2005
    ..1 and 1% was shown to increase the permeability of mannitol by 4.6-fold and 33.8-fold, respectively. The mechanism of opening of tight junctions was found to involve F-actin-related changes and redistribution of ZO-1...
  27. ncbi Transdermal delivery of ketoprofen using microemulsions
    Y S Rhee
    College of Pharmacy, Sungkyunkwan University, 440-746, Suwon Kyunggi-Do, South Korea
    Int J Pharm 228:161-70. 2001
    ..Of the four terpenes used, only limonene resulted in a powerful enhancing activity (3-fold increase over control)...
  28. ncbi Nanoparticles engineered from lecithin-in-water emulsions as a potential delivery system for docetaxel
    Nijaporn Yanasarn
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, United States
    Int J Pharm 379:174-80. 2009
    ..the engineering of a novel spherical nanoparticle formulation ( approximately 270 nm) from lecithin-in-water emulsions. Docetaxel can be incorporated into the nanoparticles, and the resultant docetaxel-nanoparticles were stable ..
  29. ncbi Topical transport of hydrophilic compounds using water-in-oil nanoemulsions
    H Wu
    Department of Pharmaceutics, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA
    Int J Pharm 220:63-75. 2001
    ....
  30. ncbi Ultrasound-assisted emulsification of cosmetic samples prior to elemental analysis by different atomic spectrometric techniques
    I Lavilla
    Departamento de Quimica Analitica y Alimentaria, Area de Quimica Analitica, Facultad de Quimica, Universidad de Vigo, As Lagoas Marcosende s n, 36310 Vigo, Spain
    Talanta 80:109-16. 2009
    ..Thermal programs, nebulization of emulsions, speed of pumps and concentration of reagents used in cold vapour generation were optimized...
  31. ncbi Enhancement of oral absorption of curcumin by self-microemulsifying drug delivery systems
    Jing Cui
    Department of Pharmaceutics, School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, PR China
    Int J Pharm 371:148-55. 2009
    ..Our study illustrated that the developed SMEDDS formulation held great potential as a possible alternative to traditional oral formulations of curcumin...
  32. ncbi Design and optimization of a new self-nanoemulsifying drug delivery system
    Lijuan Wang
    College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072, China
    J Colloid Interface Sci 330:443-8. 2009
    ..surfactants and oils were screened as candidates for SNEDDS on the basis of droplet size of the resulting emulsions. The influence of the constituent structure, concentration and the composition of SNEDDS formulations, and the ..
  33. ncbi Nasal immunization with a recombinant HIV gp120 and nanoemulsion adjuvant produces Th1 polarized responses and neutralizing antibodies to primary HIV type 1 isolates
    Anna U Bielinska
    Michigan Nanotechnology Institute for Medicine and Biological Sciences MNIMBS, University of Michigan, Ann Arbor, Michigan 48109, USA
    AIDS Res Hum Retroviruses 24:271-81. 2008
    ..This study suggests that NE should be evaluated as a mucosal adjuvant for multivalent HIV vaccines...
  34. ncbi Physicochemical characterization and biological activity of synthetic TLR4 agonist formulations
    Ryan C Anderson
    Infectious Disease Research Institute, 1124 Columbia St, Ste 400, Seattle, WA 98104, USA
    Colloids Surf B Biointerfaces 75:123-32. 2010
    ..ratios than aqueous formulations or an emulsion formulation without the agonist, and (3) appropriate plant-derived components can be substituted for animal-derived components in oil-in-water emulsions without loss of biological activity.
  35. ncbi Lipid nanoparticles for skin penetration enhancement-correlation to drug localization within the particle matrix as determined by fluorescence and parelectric spectroscopy
    S Lombardi Borgia
    , , Germany
    J Control Release 110:151-63. 2005
    ..Therefore, drug targeting appears to be more strictly related to the mode of interaction of drug and particle than penetration enhancement...
  36. ncbi Peroxisome proliferator-activated receptor-gamma coactivator-1 and insulin resistance: acute effect of fatty acids
    J Hoeks
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Diabetologia 49:2419-26. 2006
    ..We examined whether lipid-induced insulin resistance was associated with downregulation of expression of skeletal muscle genes involved in oxidative metabolism and mitochondrial biogenesis in humans...
  37. ncbi Evaluation in melanoma-bearing mice of an etoposide derivative associated to a cholesterol-rich nano-emulsion
    Ana C Lo Prete
    Faculty of Pharmaceutical Sciences, , , Brazil
    J Pharm Pharmacol 58:801-8. 2006
    ..The incorporation of etoposide oleate to LDE resulted in markedly reduced toxicity and superior antitumoral activity. LDE-etoposide oleate is a promising new weapon for cancer treatment...
  38. ncbi The universality of low-energy nano-emulsification
    Nicolas Anton
    CNRS 7199, Universite de Strasbourg, Faculte de Pharmacie, Laboratoire de Conception et Application de Molecules Bioactives, équipe de Pharmacie Biogalénique, 74 route du Rhin BP 60024 F 67401 Illkirch Cedex, France
    Int J Pharm 377:142-7. 2009
    Extensive studies have been done on nano-emulsions and emulsification methods to provide nanometric-scaled templates for the formulation of nanoparticles...
  39. ncbi Cremophor-free intravenous microemulsions for paclitaxel I: formulation, cytotoxicity and hemolysis
    Adwoa O Nornoo
    Department of Pharmaceutical Sciences, Albany College of Pharmacy, Albany, NY 12208, USA
    Int J Pharm 349:108-16. 2008
    ..This higher drug loading results in a smaller vehicle volume in required doses of these formulations and potentially less vehicle-related side effects are anticipated...
  40. ncbi NMR characterisation and transdermal drug delivery potential of microemulsion systems
    M Kreilgaard
    Department of Pharmaceutics, The Royal Danish School of Pharmacy, Universitetsparken 2, DK 2100, Copenhagen, Denmark
    J Control Release 69:421-33. 2000
    ..The microemulsions did not perturb the skin barrier, indicating a low skin irritancy...
  41. ncbi A study on the influence of emulsion droplet size on the skin penetration of tetracaine
    P Izquierdo
    Departament de Tecnologia de Tensioactius, Institut d Investigacions Quimiques i Ambientals de Barcelona, CSIC, Barcelona, Spain
    Skin Pharmacol Physiol 20:263-70. 2007
    ..For this purpose, in vitro dermal and transdermal delivery of tetracaine from 6 emulsions (3 macro-emulsions with droplet sizes >1 microm and 3 nano-emulsions with droplet sizes <100 nm) were ..
  42. ncbi In vitro permeation and in vivo anti-inflammatory and analgesic properties of nanoscaled emulsions containing ibuprofen for topical delivery
    Ghassan Z Abdullah
    School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Penang, Malaysia
    Int J Nanomedicine 6:387-96. 2011
    ..As a topical delivery system, a nanoscaled emulsion is considered a good carrier of several active ingredients that convey several side effects upon oral administration, such as nonsteroidal anti-inflammatory drugs (NSAIDs)...
  43. ncbi Structural characterisation of water-Tween 40/Imwitor 308-isopropyl myristate microemulsions using different experimental methods
    F Podlogar
    Faculty of Pharmacy, University of Ljubljana, 1000 Ljubljana, Askerceva 7, SI, Slovenia
    Int J Pharm 276:115-28. 2004
    ..In future, the ability to determine type and structure of such microemulsion systems could enable partitioning and release rates of drugs from microemulsions to be predicted...
  44. ncbi Effect of fat emulsion (Fabuless) on orocecal transit time in healthy men
    Arvo Haenni
    Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden
    Scand J Gastroenterol 44:1186-90. 2009
    ..The aim of this study was to investigate the effects of this stable fat emulsion on orocecal transit time in healthy men...
  45. ncbi Enhanced nuclear delivery and cytotoxic activity of hydroxycamptothecin using o/w emulsions
    Yongxing Zhao
    College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, PR China
    J Pharm Pharm Sci 10:61-70. 2007
    Hydroxycamptothecin-Emulsions (HCPT-E), being a promising delivery system for intravenous applications, were prepared. Here we evaluated the relation of cytotoxicity and intracellular drug amounts...
  46. ncbi Development of microemulsions to topically deliver 5-aminolevulinic acid in photodynamic therapy
    Luciana Mattoso Pires de Campos Araújo
    Department of Pharmaceutical Sciences, University of Sao Paulo, Ribeirao Preto, Brazil
    Eur J Pharm Biopharm 75:48-55. 2010
    ..The microemulsion developed carried 5-ALA to the deeper skin layers, increasing the red fluorescence of the skin and indicating the potentiality of the system for topical 5-ALA-PDT...
  47. ncbi Vehicle effects on in vitro release and skin permeation of octylmethoxycinnamate from microemulsions
    L Montenegro
    Department of Pharmaceutical Sciences, University of Catania, V le A Doria 6, 95125 Catania, Italy
    Int J Pharm 405:162-8. 2011
    ..The results of this work suggest that PIT MEs could provide controlled skin drug delivery by choosing proper associations of oil phase lipids and emulsifiers...
  48. ncbi Antioxidant activity of cysteine, tryptophan, and methionine residues in continuous phase beta-lactoglobulin in oil-in-water emulsions
    Ryan J Elias
    Department of Food Science, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Agric Food Chem 53:10248-53. 2005
    Proteins dispersed in the continuous phase of oil-in-water emulsions are capable of inhibiting lipid oxidation reactions...
  49. ncbi Applications of microemulsion based drug delivery system
    K R Jadhav
    Department of Pharmaceutics, Bharati Vidyapeeth s College of Pharmacy, CBD Belapur, Sector 8, Navi Mumbai 400614, India
    Curr Drug Deliv 3:267-73. 2006
    ....
  50. ncbi Modification of composition of a nanoemulsion with different cholesteryl ester molecular species: effects on stability, peroxidation, and cell uptake
    Cristina P Almeida
    Lipid Metabolism Laboratory, Heart Institute InCor, Medical School Hospital, University of Sao Paulo, Sao Paulo, Brazil
    Int J Nanomedicine 5:679-86. 2010
    ..Here, it was tested whether modifications of core particle constitution could affect the characteristics and biologic properties of lipid nanoemulsions...
  51. ncbi Microemulsions with timolol as potential eye drops
    I Malina
    Department of Pharmaceutical Technology, Karol Marcinkowski University of Medical Sciences, 6, Grunwaldzka Str, 60 780 Poznan, Poland
    Pharmazie 61:650-1. 2006
    ..The following physical parameters were investigated: density, dynamic viscosity, refractive index, surface tension, pH and osmotic tension. All the microemulsions met the requirements for eye drops...
  52. ncbi Spray-dried oil powder with ultrahigh oil content
    Raffaele Mezzenga
    Nestlé Research Center, Vers chez les Blanc, 1000 Lausanne 26, Switzerland
    Langmuir 26:16658-61. 2010
    ..The emulsion is then spray dried as for ordinary emulsions, however without the addition of hydrocolloids typically needed when spray drying liquid oil dispersions...
  53. ncbi Microencapsulation and oxidative stability of spray-dried fish oil emulsions
    S A Hogan
    Department of Food and Nutritional Sciences, University College Cork National University of Ireland, Cork
    J Microencapsul 20:675-88. 2003
    b>Emulsions of menhaden oil and sodium caseinate (NaCas) incorporating carbohydrates of varying dextrose equivalence (DE) were spray-dried to yield encapsulated fish oil powders. The effects of carbohydrate DE (5...
  54. ncbi Novel microemulsion enhancer formulation for simultaneous transdermal delivery of hydrophilic and hydrophobic drugs
    Philp J Lee
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Pharm Res 20:264-9. 2003
    ..CONCLUSIONS: The novel microemulsion systems in this study potentially offers many beneficial characteristics for transdermal drug delivery...
  55. ncbi Monitoring the effects of component structure and source on formulation stability and adjuvant activity of oil-in-water emulsions
    Christopher B Fox
    Infectious Disease Research Institute, 1124 Columbia Street, Suite 400, Seattle, WA 98104, United States
    Colloids Surf B Biointerfaces 65:98-105. 2008
    Oil-in-water emulsions have shown promise as safe and effective adjuvant formulations for vaccines...
  56. ncbi Transdermal delivery of capsaicin derivative-sodium nonivamide acetate using microemulsions as vehicles
    Yaw Bin Huang
    Graduate Institute of Clinical Pharmacy, Kaohsiung Medical University, 100 Shih Chuan 1st Road, Kaohsiung City 80708, Taiwan
    Int J Pharm 349:206-11. 2008
    ..2 buffer containing 25% ethanol) reported in an earlier study, therefore microemulsions could be an effective vehicle for topical delivery of SNA...
  57. ncbi Perfluorocarbon emulsions as a promising technology: a review of tissue and vascular gas dynamics
    Bruce D Spiess
    Department of Anesthesiology and Emergency Medicine, Virginia Commonwealth University Reanimation Engineering Shock Center, Richmond, Virginia, USA
    J Appl Physiol 106:1444-52. 2009
    Perfluorocarbon (PFC) emulsions are halogen-substituted carbon nonpolar oils with resultant enhanced dissolved respiratory gas (O(2), N(2), CO(2), nitric oxide) capabilities...
  58. ncbi Inactivation of Ebola virus with a surfactant nanoemulsion
    A A Chepurnov
    State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Region 630559, Russia
    Acta Trop 87:315-20. 2003
    ..Because of the excellent biocompatibility of nanoemulsions, studies are planned to determine whether the nanoemulsion-killed virus is suitable for developing a vaccine against EBO...
  59. ncbi An alternative paclitaxel microemulsion formulation: hypersensitivity evaluation and pharmacokinetic profile
    Lei He
    Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing 100083, People's Republic of China
    Int J Pharm 250:45-50. 2003
    ..29 h(-1)), showing the elimination rate was much slower in the former than in the latter. Compared with Taxol, the paclitaxel microemulsion caused less toxicity and had a longer circulation time in rats...
  60. ncbi Differences in the binding capacity of human apolipoprotein E3 and E4 to size-fractionated lipid emulsions
    Matthew A Perugini
    Department of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, Vic, Australia
    Eur J Biochem 269:5939-49. 2002
    ..were developed to investigate the binding of human apolipoprotein E (apoE) isoforms to size-fractionated lipid emulsions, and demonstrate that apoE3 binds preferentially to small lipid emulsions, whereas apoE4 exhibits a preference ..
  61. ncbi Improved drug delivery using microemulsions: rationale, recent progress, and new horizons
    R P Bagwe
    Center for Surface Science and Engineering, Dept. of Chemical Engineering, University of Florida, Gainesville, FL 32611, USA
    Crit Rev Ther Drug Carrier Syst 18:77-140. 2001
    ....
  62. ncbi Comparison of oil-in-water emulsions manufactured by microfluidization and homogenization
    S Pinnamaneni
    Department of Pharmaceutical Sciences, College of Pharmacy, Idaho State University, Pocatello, Idaho 83209-8334, USA
    Pharmazie 58:554-8. 2003
    The purpose of this study was to compare drug-free model submicron oil-in-water (o/w) emulsions manufactured by high-speed homogenization and microfluidization...
  63. ncbi Chemical stability and phase distribution of all-trans-retinol in nanoparticle-coated emulsions
    Nasrin Ghouchi Eskandar
    Ian Wark Research Institute, ARC Special Research Centre for Particle and Material Interfaces, Mawson Lakes, Adelaide, SA, Australia
    Int J Pharm 376:186-94. 2009
    ..coating on the chemical stability and phase distribution of all-trans-retinol in submicron oil-in-water emulsions is reported...
  64. ncbi Role of iron and hydroperoxides in the degradation of lycopene in oil-in-water emulsions
    Caitlin S Boon
    Department of Food Science, Chenoweth Laboratory, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Agric Food Chem 57:2993-8. 2009
    ..of the emulsion had a significant impact on the stability of lycopene, with most rapid degradation occurring in emulsions at pH 4 and below. Addition of EDTA significantly increased the stability of lycopene...
  65. ncbi Low molecular weight heparin loaded pH-sensitive microparticles
    Yvette Meissner
    InsermU734 EA3452, Faculty of Pharmacy, Nancy, France
    Int J Pharm 335:147-53. 2007
    ..These microspheres represent a promising tool for the selective oral delivery of heparin to the colon, especially interesting in the treatment of inflammatory bowel disease...
  66. ncbi Improvement of in vitro efficacy of a novel schistosomicidal drug by incorporation into nanoemulsions
    Sávia Caldeira de Araújo
    Departamento de Produtos Farmacêuticos, Faculdade de Farmacia, Universidade Federal de Minas Gerais, Av Antonio Carlos 6627, 31270 901 Belo Horizonte, MG, Brazil
    Int J Pharm 337:307-15. 2007
    ..These results indicate that cationic nanoemulsions can represent an interesting delivery system for the pharmaceutical formulation of BphEA...
  67. ncbi Formulation and characterization of curcuminoids loaded solid lipid nanoparticles
    Waree Tiyaboonchai
    Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Pitsanulok 65000, Thailand
    Int J Pharm 337:299-306. 2007
    ..The results revealed that after storage in the absence of sunlight for 6 months, the percentages of the remaining curcumin, bisdemethoxycurcumin and demethoxycurcumin were 91, 96 and 88, respectively...
  68. ncbi Effect of WOW process parameters on morphology and burst release of FITC-dextran loaded PLGA microspheres
    Shirui Mao
    Department of Pharmaceutics and Biopharmacy, Philipps Universitat Marburg, Ketzerbach 63, D 35032 Marburg, Germany
    Int J Pharm 334:137-48. 2007
    ..In summary, surface porosity and internal morphology play a significant role in the release of hydrophilic macromolecules from biodegradable microspheres in the initial release phase characterized by pore diffusion...
  69. ncbi Spontaneous transfer of phospholipid-coated oil-in-oil and water-in-oil micro-droplets through an oil/water interface
    Ayako Yamada
    Department of Physics, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan
    Langmuir 22:9824-8. 2006
    ..We found that, in both cases, micro-droplets spontaneously transferred from the oil phase to the water phase. O/O micro-droplets transformed into oil-in-water micro-droplets, while W/O micro-droplets led to the formation of liposomes...
  70. ncbi The effect of monomers on the formulation of polymeric nanocapsules based on polyureas and polyamides
    I Montasser
    Universite Lyon 1, ISPB, Laboratoire de Génie Pharmacotechnique et Biogalénique, Lyon F 69003, France
    Int J Pharm 335:176-9. 2007
    ..The permeability of the polymeric wall is related to its crystallinity and contributes to the growth of nanocapsule membrane by the diffusion of the hydrophilic monomers to get stable colloidal suspensions...
  71. ncbi Formulation and evaluation of flurbiprofen microemulsion
    K W Ambade
    Department of Pharmaceutics, Bharati Vidyapeeth s College of Pharmacy, CBD Belapur, Sector 8, Navi Mumbai, India
    Curr Drug Deliv 5:32-41. 2008
    ..Histopathological investigation of rat skin revealed the safety of microemulsion formulation for topical use. Thus the present study indicates that, microemulsion can be a promising vehicle for the topical delivery of flurbiprofen...
  72. ncbi Development and bioavailability assessment of ramipril nanoemulsion formulation
    Sheikh Shafiq
    Department of Pharmaceutics, Jamia Hamdard, Hamdard Nagar, India
    Eur J Pharm Biopharm 66:227-43. 2007
    ..49%. The present study revealed that ramipril nanoemulsion could be used as a liquid formulation for pediatric and geriatric patients and can be formulated as self-nanoemulsifying drug delivery system (SNEDDS) as a unit dosage form...
  73. ncbi Correlation between digestion of the lipid phase of smedds and release of the anti-HIV drug UC 781 and the anti-mycotic drug enilconazole from smedds
    C Goddeeris
    Laboratory of Pharmacotechnology and Biopharmacy, Catholic University of Leuven, Leuven, Belgium
    Eur J Pharm Biopharm 66:173-81. 2007
    ..Contrary to what one would assume, a higher extent of fatty acid liberation did not enhance drug release. In other words, drug release does not seem to be driven by the extent of lipid digestion...
  74. ncbi Acidic microclimate pH distribution in PLGA microspheres monitored by confocal laser scanning microscopy
    Amy G Ding
    Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109 1065, USA
    Pharm Res 25:2041-52. 2008
    ..The acidic microclimate pH (micropH) distribution inside poly(lactic-co-glycolic acid) (PLGA) microspheres was monitored quantitatively as a function of several formulation variables...
  75. ncbi Effect of preparation conditions on the nutrient release properties of alginate-whey protein granular microspheres
    Lingyun Chen
    Institut de recherche sur les nutraceutiques et les aliments fonctionnels INAF STELA, Universite Laval, Sainte Foy, Canada
    Eur J Pharm Biopharm 65:354-62. 2007
    ..By careful process design, granular microspheres with potential as oral delivery vehicles for bioactive compounds may be developed...
  76. ncbi Preparation of prospective plant oil derived micro-emulsion vehicles for drug delivery
    Syamasri Gupta
    Indian J Biochem Biophys 43:254-7. 2006
    Biocompatible oil-in-water (o/w) micro-emulsions can be prospective drug delivery vehicles for their capability to solubilize lipophilic (oil soluble) drugs in the dispersed oil. Plant oils are considered suitable for such a purpose...
  77. ncbi Characterization of water-in-oil microemulsion for oral delivery of earthworm fibrinolytic enzyme
    Mao Bo Cheng
    Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    J Control Release 129:41-8. 2008
    ..These findings indicated that the w/o microemulsion may represent a safe and effective oral delivery system for hydrophilic bioactivity macromolecules...
  78. ncbi Long acting porous microparticle for pulmonary protein delivery
    Min Jung Kwon
    Pharmaceutical and Health Research Institute, Amore Pacific Corporation R and D Center, 314 1, Bora dong, Giheung gu, Yongin si, Gyeonggi Do 446 729, Republic of Korea
    Int J Pharm 333:5-9. 2007
    ..In addition, it is expected that these particles arrive at a deep lung epithelium due to low density (high porosity) and limit macrophage recognition because of big particle size (more than 5 microm)...
  79. ncbi Formulation and biopharmaceutical evaluation of silymarin using SMEDDS
    Jong Soo Woo
    Pharmaceutical Research Lab Hanmi Pharm Co, Hwaseong 445 913, Korea
    Arch Pharm Res 30:82-9. 2007
    ..5 times higher than that from the reference capsule. After its oral administration to rats, the bioavailability of the drug from the SMEDDS was 3.6 times higher than the reference capsule...
  80. ncbi The influence of cosurfactants and oils on the formation of pharmaceutical microemulsions based on PEG-8 caprylic/capric glycerides
    Ljiljana Djekic
    Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, Vojvode Stepe 450, P O Box 146, 11221 Belgrade, Serbia
    Int J Pharm 352:231-9. 2008
    ..18% (w/w) and W(max), 65.00% (w/w) for PO) and the electrical conductivity measurement results for optimized balanced microemulsions showed that their structures were highly conductive indicating a bicontinuous microstructure...
  81. ncbi Comparison between lipolysis and compendial dissolution as alternative techniques for the in vitro characterization of alpha-tocopherol self-emulsified drug delivery systems (SEDDS)
    Hazem Ali
    Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71209 0497, United States
    Int J Pharm 352:104-14. 2008
    ..Formulation ingredients influenced each response differently; and therefore, each method can only reveal distinctive characteristics of the SEDDS formulation and may not be used interchangeably...
  82. ncbi Distribution of nobiletin chitosan-based microemulsions in brain following i.v. injection in mice
    Jing Yao
    Department of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China
    Int J Pharm 352:256-62. 2008
    ..v. administration of HCC-ME were not significantly increased relative to ME. These results indicate that HAC-ME may be presented as potential candidates for delivering more drugs into the brain...
  83. ncbi Solid lipid nanoparticles prepared by solvent diffusion method in a nanoreactor system
    Hong Yuan
    College of Pharmaceutical Science, Zhejiang University, 388 Yuhangtang Road, Hangzhou 310058, PR China
    Colloids Surf B Biointerfaces 61:132-7. 2008
    ..The in vitro drug release tests indicated that the drug release rate was faster than that of SLN prepared by the conventional method, and the drug content in SLN did not affect the in vitro drug release profile...
  84. ncbi Nanoemulsions as vehicles for transdermal delivery of aceclofenac
    Faiyaz Shakeel
    Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard Hamdard University, Hamdard Nagar, New Delhi 110062, India
    AAPS PharmSciTech 8:E104. 2007
    ..These results suggested that nanoemulsions are potential vehicles for improved transdermal delivery of aceclofenac...
  85. ncbi Effect of long-chain alcohols on SDS partitioning to the oil/water interface of emulsions and on droplet size
    Monica A James Smith
    Center for Surface Science and Engineering, University of Florida, Gainesville, FL 32611 6005, USA
    J Colloid Interface Sci 315:307-12. 2007
    ..Droplet size measurements revealed a minimum in droplet size for emulsions with added C(12)OH...
  86. ncbi Preparation and evaluation of self-microemulsifying drug delivery system of oridonin
    Ping Zhang
    School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 210203, PR China
    Int J Pharm 355:269-76. 2008
    ..The absorption of oridonin from SMEDDS showed a 2.2-fold increase in relative bioavailability compared with that of the suspension. Our studies demonstrated the promising use of SMEDDS for the delivery of oridonin by the oral route...
  87. ncbi Liquid spray formulations of xibornol by using self-microemulsifying drug delivery systems
    M Cirri
    Dip Scienze Farmaceutiche, Polo Scientifico di Sesto Fiorentino, via U Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy
    Int J Pharm 340:84-91. 2007
    ....
  88. ncbi Quality by design: characterization of self-nano-emulsified drug delivery systems (SNEDDs) using ultrasonic resonator technology
    R B Shah
    Division of Product Quality Research, Office of Testing and Research, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD 20993, United States
    Int J Pharm 341:189-94. 2007
    ..Also the ultrasonic absorption correlated droplet size of nano-emulsions linearly with R(2) of 0...
  89. ncbi Stability of vitamins C and E in topical microemulsions for combined antioxidant therapy
    Branka Rozman
    Faculty of Pharmacy, University of Ljubljana, Askerceva, SI Slovenia
    Drug Deliv 14:235-45. 2007
    ....
  90. ncbi Formulation of a cosurfactant-free O/W microemulsion using nonionic surfactant mixtures
    Y H Cho
    Department of Biotechnology, Yonsei University, Seoul, 120 749, South Korea
    J Food Sci 73:E115-21. 2008
    ..Dilution with a different aqueous medium, either water or acidic fluid, did not significantly change the microemulsion turbidity. DHA oil incorporated in microemulsion showed higher oxidation stability than free DHA oil...
  91. ncbi The partitioning of emulsifiers in o/w emulsions: a comparative study of SANS, ultrafiltration and dialysis
    Kathleen Oehlke
    Institute of Human Nutrition and Food Science, University of Kiel, 24118 Kiel, Germany
    J Colloid Interface Sci 322:294-303. 2008
    The partitioning of SDS and CTAB in o/w emulsions was investigated by ultrafiltration (UF), dialysis and small-angle neutron scattering (SANS)...
  92. ncbi Increasing the proportional content of surfactant (Cremophor EL) relative to lipid in self-emulsifying lipid-based formulations of danazol reduces oral bioavailability in beagle dogs
    Jean F Cuine
    Department of Pharmaceutics, Victorian College of Pharmacy, Monash University Parkville Campus, Parkville, Victoria, Australia
    Pharm Res 24:748-57. 2007
    ....
  93. ncbi Design and production of nanoparticles formulated from nano-emulsion templates-a review
    Nicolas Anton
    Inserm U646, Ingenierie de la Vectorisation Particulaire, 10 rue A Boquel, F 49100 Angers, France
    J Control Release 128:185-99. 2008
    ..e. polymeric or lipid nanospheres and nanocapsules) highlighting the links (or potential links) between these nanoparticles and the different nano-emulsion formulation methods upon which they are based...
  94. ncbi Bioerodible devices for intermittent release of simvastatin acid
    Ju Hyeong Jeon
    Center for Biomedical Engineering, University of Kentucky, Lexington, KY 40506 0070, USA
    Int J Pharm 340:6-12. 2007
    ..These results imply that devices intermittently releasing simvastatin acid warrant further study for locally promoting osteogenesis...
  95. ncbi Formulation of parenteral microemulsion containing itraconazole
    Yun Seok Rhee
    College of Pharmacy, Sungkyunkwan University, Suwon 440 746, Korea
    Arch Pharm Res 30:114-23. 2007
    ..Overall, these results highlight the potential of an ITZ-microemulsion formulation for the parenteral route...
  96. ncbi Pluronic and tetronic copolymers with polyglycolyzed oils as self-emulsifying drug delivery systems
    Marta Fernandez-Tarrio
    Departamento de Farmacia y Tecnologia Farmaceutica, Facultad de Farmacia, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain
    AAPS PharmSciTech 9:471-9. 2008
    ....
  97. ncbi Comparison of different water/oil microemulsions containing diclofenac sodium: preparation, characterization, release rate, and skin irritation studies
    Gülten Kantarci
    Pharmaceutical Biotechnology Department, Faculty of Pharmacy, University of Ege, 35100 Bornova Izmir, Turkey
    AAPS PharmSciTech 8:E91. 2007
    ..In conclusion, M prepared with P may be a more appropriate formulation than the other 2 formulations studied as drug carrier for topical application...
  98. ncbi Phase transition water-in-oil microemulsions as ocular drug delivery systems: in vitro and in vivo evaluation
    Judy Chan
    School of Pharmacy, The University of Auckland, Auckland, New Zealand
    Int J Pharm 328:65-71. 2007
    ..Thus, phase transition ME is promising for ocular drug delivery as it provides the fluidity with its viscosity being increased after application increasing ocular retention while retaining the therapeutic efficiency...
  99. ncbi Preparation of large porous biodegradable microspheres by using a simple double-emulsion method for capreomycin sulfate pulmonary delivery
    Stefano Giovagnoli
    Department of Chemistry and Technology of Drugs, Universita degli Studi di Perugia, Via del Liceo 1, 06123 Perugia, Italy
    Int J Pharm 333:103-11. 2007
    ..The use of RSM helped to establish the conditions to obtain formulations potentially useful for a possible CS pulmonary delivery, by using a simple preparation method with a consistent time, cost, and material saving...
  100. ncbi Amphiphilic association systems for Amphotericin B delivery
    E Esposito
    Dipartimento di Scienze Farmaceutiche, Universita di Ferrara, Via Fossato di Mortara, 19, I 44100 Ferrara, Italy
    Int J Pharm 260:249-60. 2003
    ..Microemulsions and monoglyceride-water systems were free from phase separation for up to three months and in some cases the AMB content was unchanged even after three months...
  101. ncbi G-CSF loaded biodegradable PLGA nanoparticles prepared by a single oil-in-water emulsion method
    Seung Ho Choi
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, South Korea
    Int J Pharm 311:223-8. 2006
    ..Reversed phase and size exclusion chromatograms revealed that the structural integrity of released rhG-CSF from nanoparticles was nearly intact, compared to that of native rhG-CSF...

Research Grants77

  1. Long Chain Fatty Acid (LCFA) Taste Receptor CD36 in Food Choice and Consumption
    Eric Walters; Fiscal Year: 2007
    ..We will evaluate simple oil/water emulsions, dairy, and soy milk based beverages so that we can present palatable samples which will not provide olfactory ..
  2. Sub-micrometer zero valent metal for in-situ remediation of contaminated aquifers
    JOHN FREIM; Fiscal Year: 2007
    ..The Phase I work will conclude by making zero valent metal-containing water in oil emulsions that can accomplish the in-situ remediation of non aqueous phase contaminants...
  3. METABOLISM OF INTRAVENOUS LIPID EMULSIONS
    Richard Deckelbaum; Fiscal Year: 2007
    ..of this research program is to characterize how specific types of triglycerides (TG) in intravenous (IV) lipid emulsions affect particle metabolism and impact upon the biological potentials of their component lipids...
  4. Cholestasis Reversal (Phase ll): Efficacy of lV Fish Oil
    Mark Puder; Fiscal Year: 2010
    ..Studies suggest that soybean oil containing intravenous fat emulsions (IFE) may be a major contributing factor...
  5. Antibacterial, antifungal, antiviral, and antispore paints
    YUYU contact SUN; Fiscal Year: 2010
    ..tetramethyl-4-piperidinyl acrylate (Cl-TMPA), will be polymerized to produce polymeric N-halamine latex emulsions. On adding a small amount of such emulsions into conventional water-based latex paint, the new paint will be ..
  6. Molecular Mechanisms of Dietary Fat Digestion by Pancreatic Lipases
    Mark E Lowe; Fiscal Year: 2010
    ..identified critical residues in PTL-colipase and PLRP2 that influence the absorption of these lipases to lipid emulsions. 3) Comparison and preliminary analysis of the structures of PTL and PLRP2 identified domains that can mediate ..
  7. Molecular Mechanisms of Dietary Fat Digestion by Pancreatic Lipases
    Mark Lowe; Fiscal Year: 2009
    ..identified critical residues in PTL-colipase and PLRP2 that influence the absorption of these lipases to lipid emulsions. 3) Comparison and preliminary analysis of the structures of PTL and PLRP2 identified domains that can mediate ..
  8. Cholestasis Prevention: Efficacy of IV Fish Oil
    Mark Puder; Fiscal Year: 2009
    ..Studies suggest that soybean oil containing intravenous fat emulsions (IFE) may be a major contributing factor...
  9. Genetic circuits based on allosteric ribozymes
    Andrew Ellington; Fiscal Year: 2007
    ..reactions using a novel trans-selection method based on in vitro compartmentalization (IVC) in water-in-oil emulsions. The fastest aptazymes will then be further screened for function in E. coli cells...
  10. Genetic circuits based on allosteric ribozymes
    Andrew D Ellington; Fiscal Year: 2010
    ..reactions using a novel trans-selection method based on in vitro compartmentalization (IVC) in water-in-oil emulsions. The fastest aptazymes will then be further screened for function in E. coli cells...
  11. Parenteral Medium Chain Triglycerides in the Premature
    Eberhard Schmidt Sommerfeld; Fiscal Year: 2002
    ..MCT-containing lipid emulsions are being studied in adults. No studies in premature infants have been reported in the U.S...
  12. SUPERHEATED DROP DETECTORS FOR DOSIMETRY IN RADIOTHERAPY
    Ravinder Nath; Fiscal Year: 2001
    ..Specifically, we propose: (1) to improve the photon energy response of the SEC by using emulsions containing only elements with tissue-like atomic numbers; (2) to optimize the speed of image acquisition and ..
  13. VASCULAR BUBBLE GENERATION FOR DIAGNOSIS AND THERAPY
    PAUL CARSON; Fiscal Year: 2007
    ..by bubbles from intra-arterial droplet injections to occlusion by bubbles from intravenous injections of droplet emulsions. After achieving the generation of necessary bubble concentrations from transpulmonary droplets, similar copious ..
  14. Early Events in Lipoprotein Assembly
    CHRISTOPHER MCKNIGHT; Fiscal Year: 2009
    ..fragments of ApoS in a cell free system supplemented with phospholipids and phospholipid-triacylglycerol emulsions to test the hypothesis that cotranslational interaction of ApoS with lipids is spontaneous and essential for the ..