emulsions

Summary

Summary: Colloids of two immiscible liquids where either phase may be either fatty or aqueous; lipid-in-water emulsions are usually liquid, like milk or lotion and water-in-lipid emulsions tend to be creams.

Top Publications

  1. doi Neuroprotective effect of erythropoietin-loaded composite microspheres on retinal ganglion cells in rats
    Xianfang Rong
    Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Shanghai Medical College, Fudan University, No 83 Fenyang Road, Shanghai, China
    Eur J Pharm Sci 43:334-42. 2011
  2. ncbi Amplification of complex gene libraries by emulsion PCR
    Richard Williams
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    Nat Methods 3:545-50. 2006
  3. ncbi Microemulsion-based media as novel drug delivery systems
    M J Lawrence
    Department of Pharmacy, King s College London, Franklin Wilkins Building, 150 Stamford Street, SE1 9NN, London, UK
    Adv Drug Deliv Rev 45:89-121. 2000
  4. pmc Simultaneous transfer of cholesterol, triglycerides, and phospholipids to high-density lipoprotein in aging subjects with or without coronary artery disease
    Carolina H M Azevedo
    Lipid Metabolism Laboratory, Heart Institute, Faculdade de Medicina da Universidade de Sao Paulo, Brazil
    Clinics (Sao Paulo) 66:1543-8. 2011
  5. pmc Comparison of the ocular tolerability of a latanoprost cationic emulsion versus conventional formulations of prostaglandins: an in vivo toxicity assay
    Hong Liang
    Paris Descartes University, Faculty of Biological and Pharmacological Sciences, Department of Toxicology, Paris, France
    Mol Vis 15:1690-9. 2009
  6. ncbi Preparation of nimodipine-loaded microemulsion for intranasal delivery and evaluation on the targeting efficiency to the brain
    Qizhi Zhang
    Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 200032, PR China
    Int J Pharm 275:85-96. 2004
  7. ncbi Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs
    R Neslihan Gursoy
    Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 06100 Ankara, Turkey
    Biomed Pharmacother 58:173-82. 2004
  8. ncbi Deposition of free cholesterol in the blood vessels of patients with coronary artery disease: a possible novel mechanism for atherogenesis
    Ricardo D Couto
    Lipid Metabolism Laboratory and the Surgical Division, the Heart Institute InCor of the Medical School Hospital, University of Sao Paulo, Sao Paulo, Brazil
    Lipids 42:411-8. 2007
  9. pmc Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions
    Natalya Rapoport
    Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA
    J Control Release 153:4-15. 2011
  10. ncbi BEAMing: single-molecule PCR on microparticles in water-in-oil emulsions
    Frank Diehl
    The Howard Hughes Medical Institute, and The Ludwig Center for Cancer Genetics and Therapeutics, The Johns Hopkins Kimmel Cancer Center, 1650 Orleans Street, Baltimore, Maryland 21231, USA
    Nat Methods 3:551-9. 2006

Research Grants

Detail Information

Publications279 found, 100 shown here

  1. doi Neuroprotective effect of erythropoietin-loaded composite microspheres on retinal ganglion cells in rats
    Xianfang Rong
    Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Shanghai Medical College, Fudan University, No 83 Fenyang Road, Shanghai, China
    Eur J Pharm Sci 43:334-42. 2011
    ..So we can draw a conclusion that the EPO-loaded PLGA/PLA microspheres were feasible for neurodegeneration diseases in the retina and central nervous system (CNS)...
  2. ncbi Amplification of complex gene libraries by emulsion PCR
    Richard Williams
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    Nat Methods 3:545-50. 2006
  3. ncbi Microemulsion-based media as novel drug delivery systems
    M J Lawrence
    Department of Pharmacy, King s College London, Franklin Wilkins Building, 150 Stamford Street, SE1 9NN, London, UK
    Adv Drug Deliv Rev 45:89-121. 2000
    ..The use of microemulsions and closely related microemulsion-based systems as drug delivery vehicles is reviewed, with particular emphasis being placed on recent developments and future directions...
  4. pmc Simultaneous transfer of cholesterol, triglycerides, and phospholipids to high-density lipoprotein in aging subjects with or without coronary artery disease
    Carolina H M Azevedo
    Lipid Metabolism Laboratory, Heart Institute, Faculdade de Medicina da Universidade de Sao Paulo, Brazil
    Clinics (Sao Paulo) 66:1543-8. 2011
    ..To verify whether the capacity of high-density lipoprotein (HDL) to simultaneously receive nonesterified cholesterol, triglycerides, cholesteryl esters, and phospholipids changes with aging and the presence of coronary artery disease...
  5. pmc Comparison of the ocular tolerability of a latanoprost cationic emulsion versus conventional formulations of prostaglandins: an in vivo toxicity assay
    Hong Liang
    Paris Descartes University, Faculty of Biological and Pharmacological Sciences, Department of Toxicology, Paris, France
    Mol Vis 15:1690-9. 2009
    ..005% latanoprost, 0.004% travoprost, 0.03% bimatoprost (containing 0.02%, 0.015%, and 0.005% BAC, respectively), and 0.005% latanoprost in a new cationic emulsion (LCEm) formulation...
  6. ncbi Preparation of nimodipine-loaded microemulsion for intranasal delivery and evaluation on the targeting efficiency to the brain
    Qizhi Zhang
    Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 200032, PR China
    Int J Pharm 275:85-96. 2004
    ..v. administration. These results suggest that the microemulsion system is a promising approach for intranasal delivery of NM for the treatment and prevention of neurodegenerative diseases...
  7. ncbi Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs
    R Neslihan Gursoy
    Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 06100 Ankara, Turkey
    Biomed Pharmacother 58:173-82. 2004
    ..can be orally administered in soft or hard gelatin capsules and form fine relatively stable oil-in-water (o/w) emulsions upon aqueous dilution owing to the gentle agitation of the gastrointestinal fluids...
  8. ncbi Deposition of free cholesterol in the blood vessels of patients with coronary artery disease: a possible novel mechanism for atherogenesis
    Ricardo D Couto
    Lipid Metabolism Laboratory and the Surgical Division, the Heart Institute InCor of the Medical School Hospital, University of Sao Paulo, Sao Paulo, Brazil
    Lipids 42:411-8. 2007
    ..Considering LDE as an artificial nanoemulsion model for LDL, our results suggest that dissociation of FC from lipoprotein particles and deposition in the vessel wall may play a role as an independent mechanism in atherogenesis...
  9. pmc Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions
    Natalya Rapoport
    Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA
    J Control Release 153:4-15. 2011
    ..Anticipated mechanisms of the observed effects are discussed...
  10. ncbi BEAMing: single-molecule PCR on microparticles in water-in-oil emulsions
    Frank Diehl
    The Howard Hughes Medical Institute, and The Ludwig Center for Cancer Genetics and Therapeutics, The Johns Hopkins Kimmel Cancer Center, 1650 Orleans Street, Baltimore, Maryland 21231, USA
    Nat Methods 3:551-9. 2006
  11. ncbi Ultrasound mediates the release of curcumin from microemulsions
    Mei Hwa Lee
    Department of Materials Science and Engineering, I Shou University, Kaohsiung 840, Taiwan
    Langmuir 24:1707-13. 2008
    ..Although cargo in microemulsions is partitioned, rather than encapsulated (as in, for example, liposomes), these new results demonstrate that microemulsion carriers are feasible for some ultrasonic drug delivery applications...
  12. doi Enhancement of oral bioavailability of atorvastatin calcium by self-emulsifying drug delivery systems (SEDDS)
    Pawan J Kadu
    R C Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule, Maharashtra, India
    Pharm Dev Technol 16:65-74. 2011
    ..The formulation significantly reduced serum lipid levels as compared with atorvastatin calcium. Thus studies illustrated the potential use for the delivery of hydrophobic drug such as atorvastatin calcium by oral route...
  13. ncbi Microemulsions for topical delivery of estradiol
    S Peltola
    Department of Pharmaceutics, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    Int J Pharm 254:99-107. 2003
    ..extensive first pass metabolism after oral administration, transdermal administration of estradiol in gels and emulsions has been used to improve its bioavailability, prolong activity and to optimize metabolic profile...
  14. doi Polymer-based nanocapsules for drug delivery
    C E Mora-Huertas
    Universite de Lyon, F 69622, Lyon, France
    Int J Pharm 385:113-42. 2010
    ..Consequently, the information obtained allows establishing criteria for selecting a method for preparation of nanocapsules according to its advantages, limitations and behaviours as a drug carrier...
  15. pmc Preparation and in vivo evaluation of SMEDDS (self-microemulsifying drug delivery system) containing fenofibrate
    Ashok R Patel
    Centre for Novel Drug Delivery Systems, Department of Pharmaceutical Sciences, University Institute of Chemical Technology, Matunga, Mumbai, India
    AAPS J 9:E344-52. 2007
    ..Thus, the study confirmed that the SMEDDS formulation can be used as a possible alternative to traditional oral formulations of fenofibrate to improve its bioavailability...
  16. ncbi Microemulsions: an overview and pharmaceutical applications
    S Tenjarla
    Serquest, a Southern Research Institute Company, Birmingham, AL 35205, USA
    Crit Rev Ther Drug Carrier Syst 16:461-521. 1999
    ..Several references are cited, but the list is by no means exhaustive. The review is written so that a newcomer to the field can easily grasp the important facts pertaining to this novel delivery system...
  17. ncbi Cremophor-free intravenous microemulsions for paclitaxel II. Stability, in vitro release and pharmacokinetics
    Adwoa O Nornoo
    Department of Pharmaceutical Sciences, Albany College of Pharmacy, Albany, NY 12208, USA
    Int J Pharm 349:117-23. 2008
    ....
  18. doi Transdermal delivery of hydrocortisone from eucalyptus oil microemulsion: effects of cosurfactants
    Gamal M El Maghraby
    Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, P O Box 2457, Saudi Arabia
    Int J Pharm 355:285-92. 2008
    ..Ethanol produced the greatest effect followed by propylene glycol and isopropanol. The presence of cosurfactant and its type can thus affect both the phase behavior and the transdermal delivery potential of microemulsion...
  19. ncbi The effect of lidocaine on the globule size distribution of propofol emulsions
    Jong Woo Park
    Department of Pharmaceutics, College of Pharmacy, Sungkyunkwan University, Suwon, South Korea
    Anesth Analg 97:769-71. 2003
    ..Its increase was minimized by the addition of L-lysine to the propofol emulsion...
  20. doi Effectiveness, safety, and pharmacokinetic and pharmacodynamic characteristics of microemulsion propofol in patients undergoing elective surgery under total intravenous anaesthesia
    J A Jung
    Department of Clinical Pharmacology and Therapeutics, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Pungnap 2 dong, Songpa Gu, Seoul 138 736, Korea
    Br J Anaesth 104:563-76. 2010
    ..The aims of this study were to investigate the effectiveness, safety, pharmacokinetics, and pharmacodynamics of microemulsion propofol, Aquafol (Daewon Pharmaceutical Co., Ltd, Seoul, Republic of Korea)...
  21. ncbi PLGA nanoparticles of different surface properties: preparation and evaluation of their body distribution
    Farnaz Esmaeili
    Novel Drug Delivery Systems Laboratory, Department of Pharmaceutics, Faculty of Pharmacy, Medical Sciences University of Tehran, P O Box 14155 6451, Tehran, Iran
    Int J Pharm 349:249-55. 2008
    ....
  22. ncbi Microemulsions: a novel approach to enhanced drug delivery
    Sushama Talegaonkar
    Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, India
    Recent Pat Drug Deliv Formul 2:238-57. 2008
    ..also reflects the tremendous potential of these newer drug therapeutic systems. A critical evaluation of recent patents claiming different approaches to improve the drug delivery is the focus of the current review...
  23. doi Development of protein delivery microsphere system by a novel S/O/O/W multi-emulsion
    Weien Yuan
    Shanghai Jiaotong University, School of Pharmacy, 800 Dongchuan Road, Shanghai 200240, People s Republic of China
    Eur J Pharm Sci 36:212-8. 2009
    ..The dextran glassy particles can stabilize proteins in the PLGA matrix, which is the major advantage of this novel protein sustained-release system over preparation for the PLGA microspheres using W/O/W double-emulsion method...
  24. doi Enhanced bioavailability of lacidipine via microemulsion based transdermal gels: formulation optimization, ex vivo and in vivo characterization
    Ramesh Gannu
    National Facilities in Engineering and Technology with Industrial Collaboration NAFETIC Centre, University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506 009, Andhra Pradesh, India
    Int J Pharm 388:231-41. 2010
    ..Microemulsion based transdermal therapeutic system of LCDP was developed and optimized using Box-Behnken statistical design and could provide an effective treatment in the management of hypertension...
  25. ncbi Lipid-based delivery systems for improving the bioavailability and lymphatic transport of a poorly water-soluble LTB4 inhibitor
    D J Hauss
    Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut 06877 0368, USA
    J Pharm Sci 87:164-9. 1998
    ....
  26. doi Formulation design of microemulsion for dermal delivery of penciclovir
    Weiwei Zhu
    Department of Pharmaceutics, College of Pharmacy, Shandong University, Jinan 250012, China
    Int J Pharm 360:184-90. 2008
    ..5 times that of the commercial cream. The conclusion was that the permeating ability of penciclovir was significantly increased from the microemulsion formulation compared with commercial cream...
  27. pmc Nanoparticles engineered from lecithin-in-water emulsions as a potential delivery system for docetaxel
    Nijaporn Yanasarn
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, United States
    Int J Pharm 379:174-80. 2009
    ..the engineering of a novel spherical nanoparticle formulation ( approximately 270 nm) from lecithin-in-water emulsions. Docetaxel can be incorporated into the nanoparticles, and the resultant docetaxel-nanoparticles were stable ..
  28. doi Enhanced humoral and Type 1 cellular immune responses with Fluzone adjuvanted with a synthetic TLR4 agonist formulated in an emulsion
    Susan L Baldwin
    Infectious Disease Research Institute, 1124 Columbia Street, Suite 400, Seattle, WA 98104, United States
    Vaccine 27:5956-63. 2009
    ....
  29. doi Docetaxel microemulsion for enhanced oral bioavailability: preparation and in vitro and in vivo evaluation
    Yong Mei Yin
    College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
    J Control Release 140:86-94. 2009
    ..These results encourage further development of docetaxel microemulsions as an oral drug delivery system...
  30. pmc Pre-clinical evaluation of a novel nanoemulsion-based hepatitis B mucosal vaccine
    Paul E Makidon
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 3:e2954. 2008
    ..A new nasal hepatitis B vaccine composed of recombinant hepatitis B surface antigen (HBsAg) in a novel nanoemulsion (NE) adjuvant (HBsAg-NE) could be effective with fewer administrations...
  31. ncbi Microemulsion formulation for enhanced absorption of poorly soluble drugs. II. In vivo study
    Kohsaku Kawakami
    Developmental Research Laboratories, Shionogi and Co, Ltd, 12 4 Sagisu 5 chome, Fukushima ku, 553 0002, Osaka, Japan
    J Control Release 81:75-82. 2002
    ..HCO-60 and Tween 80-based formulations were mild to the organs, while BL-9EX-based formulation caused serious damage. The behavior and absorption mechanism of the microemulsion formulations are discussed...
  32. ncbi Single-molecule PCR using water-in-oil emulsion
    Michihiko Nakano
    Department of Ecological Engineering, Toyohashi University of Technology, Tempaku cho, Toyohashi, Aichi 441 8580, Japan
    J Biotechnol 102:117-24. 2003
    ..The W/O emulsion was broken and the second PCR step was carried out. This method can be easily applied to amplify a single DNA molecule...
  33. doi Curcumin enhances oral bioavailability and anti-tumor therapeutic efficacy of paclitaxel upon administration in nanoemulsion formulation
    Srinivas Ganta
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, Massachusetts 02115, USA
    J Pharm Sci 99:4630-41. 2010
    ..The results of this study suggest that combination of PTX and CUR, administered in nanoemulsions, could improve oral bioavailability and therapeutic efficacy in ovarian adenocarcinoma...
  34. doi Bioavailability of probucol from lipid and surfactant based formulations in minipigs: influence of droplet size and dietary state
    Flemming Seier Nielsen
    Department of Pharmaceutics, The Danish University of Pharmaceutical Sciences, Copenhagen, Denmark
    Eur J Pharm Biopharm 69:553-62. 2008
    ..Comparing the absorption in fasted and fed minipigs showed that probucol exhibited no significant food effect, when formulated in a lipid and surfactant based formulations...
  35. doi Optimization and in situ intestinal absorption of self-microemulsifying drug delivery system of oridonin
    Ying Liu
    School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 210203, PR China
    Int J Pharm 365:136-42. 2009
    ..Our results demonstrate CCD is of value in optimizing the SMEDDS formulation and understanding the effects of formulation compositions on SMEDDS properties...
  36. doi Nano-sized water-in-oil-in-water emulsion enhances intestinal absorption of calcein, a high solubility and low permeability compound
    Kenjiro Koga
    Department of Clinical Pharmaceutics, Hokuriku University, Kanazawa, Japan
    Eur J Pharm Biopharm 74:223-32. 2010
    Our goal was to develop safe and stable multilayer emulsions capable of enhancing intestinal absorption of biopharmaceutics classification system (BCS) class III drugs...
  37. doi Nanoparticles by spray drying using innovative new technology: the Büchi nano spray dryer B-90
    Xiang Li
    Faculte de Pharmacie, UMR CNRS 7199 Laboratoire de Conception et Application de Molécules Bioactives, équipe de Pharmacie Biogalénique, Universite de Strasbourg, 74 route du Rhin BP 60024 F 67401 Illkirch Cedex, France
    J Control Release 147:304-10. 2010
    Spray drying technology is widely known and used to transform liquids (solutions, emulsions, suspension, slurries, pastes or even melts) into solid powders...
  38. ncbi Effect of mannose density on mannose receptor-mediated cellular uptake of mannosylated O/W emulsions by macrophages
    Wassana Yeeprae
    Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Control Release 114:193-201. 2006
    Carbohydrate grafted emulsions are one of the most promising cell-specific targeting systems for lipophilic drugs...
  39. ncbi Preparing polymer-based sustained-release systems without exposing proteins to water-oil or water-air interfaces and cross-linking reagents
    Tuo Jin
    Shanghai JiaoTong University School of Pharmacy, China
    J Control Release 128:50-9. 2008
    ....
  40. ncbi Enhancement of stability and skin permeation by sucrose stearate and cyclodextrins in progesterone nanoemulsions
    Victoria Klang
    University of Vienna, Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Life Sciences, Althanstrasse 14, 1090 Vienna, Austria
    Int J Pharm 393:152-60. 2010
    ....
  41. ncbi Development and evaluation of self-microemulsifying liquid and pellet formulations of curcumin, and absorption studies in rats
    Saipin Setthacheewakul
    Department of Pharmaceutical Technology, Prince of Songkla University, Songkhla, Thailand
    Eur J Pharm Biopharm 76:475-85. 2010
    ..These studies demonstrate that the new self-microemulsifying systems in liquid and pellet forms are promising strategies for the formulation of poorly soluble lipophilic compounds with low oral bioavailability...
  42. ncbi Oral bioavailability enhancement of acyclovir by self-microemulsifying drug delivery systems (SMEDDS)
    Deepa Patel
    TIFAC CORE IN NDDS, Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Vadodara, India
    Drug Dev Ind Pharm 33:1318-26. 2007
    ..5 fold increase in bioavailability compared with the pure drug solution. Our studies illustrated the potential use of SMEDDS for the delivery of hydrophobic compounds such as acyclovir by oral route...
  43. doi Preparation and evaluation of self-nanoemulsified drug delivery systems (SNEDDSs) of matrine based on drug-phospholipid complex technique
    Jinghua Ruan
    Key Laboratory of Drug Targeting, Ministry of Education, Sichuan University, No 17, Section 3, Southern Renmin Road, Chengdu 610041, PR China
    Int J Pharm 386:282-90. 2010
    ..In conclusion, the absolute bioavailability of matrine drastically increased from 25% to 84.6% by the formation of MPC-SNEDDS, with an outstanding relative bioavailability of 338%, suggesting its great potential for clinical application...
  44. doi Oral microemulsions of paclitaxel: in situ and pharmacokinetic studies
    Adwoa O Nornoo
    Department of Pharmaceutical Sciences, Albany College of Pharmacy, Albany, NY 12208 3492, USA
    Eur J Pharm Biopharm 71:310-7. 2009
    ..The area-under-the-curve of PAC in CM was significantly larger than LBM, CPM and CE. Oral microemulsions of PAC were developed that increased both the permeability and AUC of PAC as compared to CE...
  45. doi How to prepare and stabilize very small nanoemulsions
    Thomas Delmas
    CEA LETI, Campus MINATEC, Département des Technologies pour la Biologie et la Santé, 17 rue des Martyrs, F 38054 Grenoble, France
    Langmuir 27:1683-92. 2011
    ..However, as exemplified in the present work, nanoemulsion systems can present very long-term kinetic stability...
  46. ncbi The protective effects of emulsified isoflurane on myocardial ischemia and reperfusion injury in rats
    Zhao Yang Hu
    Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People s Republic of China
    Can J Anaesth 56:115-25. 2009
    ..The purpose of this study was to examine the effect of emulsified isoflurane, a new formulation of isoflurane in lipid emulsion, administered intravenously in an ischemia and reperfusion model of myocardial injury...
  47. doi Self-nanoemulsifying drug delivery systems of tamoxifen citrate: design and optimization
    Yosra S R Elnaggar
    Department of Pharmaceutics, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt yosra
    Int J Pharm 380:133-41. 2009
    ..Realizing drug incorporation into an optimized nano-sized SNEDD system that encompasses a bioactive surfactant, our results proposed that the prepared system could be promising to improve oral efficacy of the tamoxifen citrate...
  48. ncbi Drug delivery strategies for poorly water-soluble drugs
    Alfred Fahr
    Friedrich Schiller Universitat Jena, Institute for Pharmacy, Lessingstrasse 8, D 07743 Jena, Germany
    Expert Opin Drug Deliv 4:403-16. 2007
    ..This article addresses the emerging formulation designs for delivering of poorly water-soluble drugs...
  49. pmc Interaction of melittin peptides with perfluorocarbon nanoemulsion particles
    Sun Joo Lee
    Department of Biochemistry and Molecular Biophysics, Center for Computational Biology, Washington University in St Louis, St Louis, Missouri 63130, USA
    J Phys Chem B 115:15271-9. 2011
    ..These results suggest that melittin interacts with the monolayer of PFOB-NEP in a way that is similar way to its interaction with bilayers but that deeper penetration into the hydrophobic interior is inhibited...
  50. doi Biocompatible surfactants for water-in-fluorocarbon emulsions
    C Holtze
    Department of Physics and School of Engineering and Applied Sciences, Harvard University, Cambridge, USA
    Lab Chip 8:1632-9. 2008
    Drops of water-in-fluorocarbon emulsions have great potential for compartmentalizing both in vitro and in vivo biological systems; however, surfactants to stabilize such emulsions are scarce...
  51. doi Design of fenofibrate microemulsion for improved bioavailability
    LianDong Hu
    School of Pharmaceutical Sciences, Hebei University, Baoding 071002, China
    Int J Pharm 420:251-5. 2011
    ..63 and 1.30-fold higher than that of the capsule. Our results indicated that the microemulsions could be used as an effective formulation for enhancing the oral bioavailability of fenofibrate...
  52. doi Clinical review: topical ophthalmic use of cyclosporin A
    Canan Asli Utine
    The Ocular Surface Diseases and Dry Eye Clinic, The Wilmer Eye Institute, Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Ocul Immunol Inflamm 18:352-61. 2010
    ..This article aims to evaluate the peer-reviewed published scientific literature and to define well-established uses of CsA eyedrops in the field of ocular surface diseases...
  53. ncbi Ultrafine medicated fibers electrospun from W/O emulsions
    Xiuling Xu
    State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
    J Control Release 108:33-42. 2005
    Ultrafine fibers containing water-soluble drugs were successfully electrospun from water-in-oil (W/O) emulsions, in which the aqueous phase contained the water-soluble drugs and the oily phase was a chloroform solution of amphiphilic ..
  54. doi Characterization and antimicrobial activity of a pharmaceutical microemulsion
    Hui Zhang
    Department of Food Science and Nutrition, Huajiachi Campus, Zhejiang University, Hangzhou 310029, China
    Int J Pharm 395:154-60. 2010
    ....
  55. pmc In vitro permeation and in vivo anti-inflammatory and analgesic properties of nanoscaled emulsions containing ibuprofen for topical delivery
    Ghassan Z Abdullah
    School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Penang, Malaysia
    Int J Nanomedicine 6:387-96. 2011
    ..As a topical delivery system, a nanoscaled emulsion is considered a good carrier of several active ingredients that convey several side effects upon oral administration, such as nonsteroidal anti-inflammatory drugs (NSAIDs)...
  56. ncbi Optimization of tocol emulsions for the intravenous delivery of clarithromycin
    Jie Li
    Shenyang Pharmaceutical University, Shenyang, China
    Int J Pharm 356:282-90. 2008
    In the present study, novel less-painful tocol emulsions for the intravenous delivery of clarithromycin were prepared and optimized...
  57. pmc Controlled and targeted tumor chemotherapy by ultrasound-activated nanoemulsions/microbubbles
    Natalya Y Rapoport
    Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA
    J Control Release 138:268-76. 2009
    ....
  58. doi Comparison of 5 intravenous lipid emulsions and their effects on hepatic steatosis in a murine model
    Jonathan A Meisel
    Department of Surgery and the Vascular Biology Program, Children s Hospital Boston, Boston, MA 02115, USA
    J Pediatr Surg 46:666-73. 2011
    Plant-based intravenous lipid emulsions have been shown to contribute to parenteral nutrition-associated liver disease (PNALD). There is mounting evidence that fish oil-based emulsions may prevent this liver injury...
  59. pmc Multifunctional nanoemulsion platform for imaging guided therapy evaluated in experimental cancer
    Anita Gianella
    Translational and Molecular Imaging Institute, Department of Radiology, Mount Sinai School of Medicine, New York, New York 10029, United States
    ACS Nano 5:4422-33. 2011
    ..This study demonstrated that our nanoemulsions, when loaded with PAV, iron oxide nanocrystals, and Cy7, represent a flexible and unique theranostic nanoparticle platform that can be applied for imaging guided therapy of cancer...
  60. doi In vitro permeation and in vivo whitening effect of topical hesperetin microemulsion delivery system
    Yi Hung Tsai
    Faculty of Pharmacy, Kaohsiung Medical University, 100 Shih Chuan 1st Road, Kaohsiung City 80708, Taiwan
    Int J Pharm 388:257-62. 2010
    ....
  61. doi Microemulsions as drug delivery systems to improve the solubility and the bioavailability of poorly water-soluble drugs
    Cai Xia He
    Zhejiang University, Institute of Pharmaceutics, 388 Yuhangtang Road, Hangzhou 310058, Zhejiang, China
    Expert Opin Drug Deliv 7:445-60. 2010
    ..An understanding of the physicochemical and biopharmaceutical characteristics of the microemulsions according to administration routes will provide guidance for designing the formulations of microemulsions...
  62. ncbi Enhanced oral bioavailability of daidzein by self-microemulsifying drug delivery system
    Qi Shen
    School of Pharmacy, Shanghai Jiao Tong University, Dongchuan Road 800, Shanghai 200240, China
    Chem Pharm Bull (Tokyo) 58:639-43. 2010
    ..Relative bioavailability of SMEDDS was enhanced about 2.5-fold compared with that of the control group. The data suggest that the use of SMEDDS provide a potential way of daidzein administered orally...
  63. ncbi Ocular antisense oligonucleotide delivery by cationic nanoemulsion for improved treatment of ocular neovascularization: an in-vivo study in rats and mice
    Tal Hagigit
    The Institute for Drug Research, The School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
    J Control Release 160:225-31. 2012
    ....
  64. ncbi The influence of cosurfactants and oils on the formation of pharmaceutical microemulsions based on PEG-8 caprylic/capric glycerides
    Ljiljana Djekic
    Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, Vojvode Stepe 450, P O Box 146, 11221 Belgrade, Serbia
    Int J Pharm 352:231-9. 2008
    ..18% (w/w) and W(max), 65.00% (w/w) for PO) and the electrical conductivity measurement results for optimized balanced microemulsions showed that their structures were highly conductive indicating a bicontinuous microstructure...
  65. doi Water-in-oil-in-water double emulsions: an excellent delivery system for improving the oral bioavailability of pidotimod in rats
    Xiaole Qi
    Pharmaceutical Research Institute, China Pharmaceutical University, Nanjing, China
    J Pharm Sci 100:2203-11. 2011
    The aims of this study were to prepare fine pidotimod-containing water-in-oil-in-water (W/O/W) double emulsions and to investigate the possibility of those emulsions as a delivery system for promoting the oral bioavailability of ..
  66. ncbi Investigation of microemulsion system for transdermal delivery of meloxicam
    Yue Yuan
    Laboratory of Drug Metabolism and Pharmacokinetics, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, People s Republic of China
    Int J Pharm 321:117-23. 2006
    ..The optimum formulation with the highest skin permeation rate (5.40 microg/cm2/h) consisted of 0.375% meloxicam, 5% IPM, 50% Tween 85/ethanol (1:1) and water...
  67. ncbi The effect of internal structure of selected water-Tween 40-Imwitor 308-IPM microemulsions on ketoprofene release
    F Podlogar
    University of Ljubljana, Faculty of Pharmacy, 1000 Ljubljana, Askerceva 7, SI, Slovenia
    Int J Pharm 302:68-77. 2005
    ..Combining different methods to obtain the physical and structural properties of microemulsions can be thus used to predict the release of ketoprofen from a microemulsion...
  68. ncbi Intestinal lymphatic transport of halofantrine occurs after oral administration of a unit-dose lipid-based formulation to fasted dogs
    Shui Mei Khoo
    Department of Pharmaceutics, Victorian College of Pharmacy, Monash University, Parkville, Victoria 3052, Australia
    Pharm Res 20:1460-5. 2003
    ....
  69. ncbi Enhancing intestinal drug solubilisation using lipid-based delivery systems
    Christopher J H Porter
    Department of Pharmaceutics, Victorian College of Pharmacy, Monash University Parkville Campus, Parkville, Victoria 3052, Australia
    Adv Drug Deliv Rev 60:673-91. 2008
    ..Finally, a series of seven guiding principles for formulation design of lipid-based delivery systems are suggested based on an analysis of recent data generated in our laboratories and elsewhere...
  70. ncbi The novel formulation design of O/W microemulsion for improving the gastrointestinal absorption of poorly water soluble compounds
    Hiroshi Araya
    Formulation Technology Research Department, Pharmaceutical Technology Division, Chugai Pharmaceutical Co Ltd, 5 1, Ukima 5 chome, Kita ku, Tokyo 115 8543, Japan
    Int J Pharm 305:61-74. 2005
    ..Accordingly, this novel O/W microemulsion is a useful formulation, which enhances the oral bioavailability by raising the solubility of poorly water soluble compounds...
  71. ncbi Solid lipid nanoparticles for enhancing vinpocetine's oral bioavailability
    Yifan Luo
    School of Pharmacy, Department of Pharmaceutics, Mailbox 42, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016 Liaoning, P R China
    J Control Release 114:53-9. 2006
    ..These results indicated that VIN absorption is enhanced significantly by employing SLN formulations. SLNs offer a new approach to improve the oral bioavailability of poorly soluble drugs...
  72. ncbi Enhancement of transdermal delivery of theophylline using microemulsion vehicle
    X Zhao
    Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210038, PR China
    Int J Pharm 327:58-64. 2006
    ..65-fold higher than that of oral solution administration. These studies showed that microemulsion system of theophylline might be promising vehicles for the transdermal delivery of theophylline...
  73. doi Paclitaxel associated with cholesterol-rich nanoemulsions promotes atherosclerosis regression in the rabbit
    Raul C Maranhão
    Heart Institute of the Medical School Hospital InCor, University of Sao Paulo, Sao Paulo, Brazil
    Atherosclerosis 197:959-66. 2008
    ..LDE-paclitaxel treatment had no toxicity. In conclusion, LDE-paclitaxel produced pronounced atherosclerosis regression without toxicity and has shown remarkable potential in cardiovascular therapeutics...
  74. ncbi A study of microemulsion systems for transdermal delivery of triptolide
    Huabing Chen
    Institute of Materia Medica, College of Life Science and Technology, Huazhong University of Science and Technology, 430074 Wuhan, China
    J Control Release 98:427-36. 2004
    ..025% triptolide revealed the significant skin irritation. The results indicate that the studied microemulsion systems, especially ME6, may be promising vehicles for the transdermal delivery of triptolide...
  75. doi Ultrasound-assisted emulsification of cosmetic samples prior to elemental analysis by different atomic spectrometric techniques
    I Lavilla
    Departamento de Quimica Analitica y Alimentaria, Area de Quimica Analitica, Facultad de Quimica, Universidad de Vigo, As Lagoas Marcosende s n, 36310 Vigo, Spain
    Talanta 80:109-16. 2009
    ..Thermal programs, nebulization of emulsions, speed of pumps and concentration of reagents used in cold vapour generation were optimized...
  76. doi Enhancement of oral absorption of curcumin by self-microemulsifying drug delivery systems
    Jing Cui
    Department of Pharmaceutics, School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, PR China
    Int J Pharm 371:148-55. 2009
    ..Our study illustrated that the developed SMEDDS formulation held great potential as a possible alternative to traditional oral formulations of curcumin...
  77. ncbi Transdermal delivery of ketoprofen using microemulsions
    Y S Rhee
    College of Pharmacy, Sungkyunkwan University, 440-746, Suwon Kyunggi-Do, South Korea
    Int J Pharm 228:161-70. 2001
    ..Of the four terpenes used, only limonene resulted in a powerful enhancing activity (3-fold increase over control)...
  78. doi Design and optimization of a new self-nanoemulsifying drug delivery system
    Lijuan Wang
    College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072, China
    J Colloid Interface Sci 330:443-8. 2009
    ..surfactants and oils were screened as candidates for SNEDDS on the basis of droplet size of the resulting emulsions. The influence of the constituent structure, concentration and the composition of SNEDDS formulations, and the ..
  79. ncbi Cetyl palmitate-based NLC for topical delivery of Coenzyme Q(10) - development, physicochemical characterization and in vitro release studies
    Veerawat Teeranachaideekul
    Department of Pharmacy, Mahidol University, Bangkok, Thailand
    Eur J Pharm Biopharm 67:141-8. 2007
    ..The NLC release patterns were defined by an initial fast release in comparison to the release of NE followed by a prolonged release, which was dependent on the oil content...
  80. ncbi Topical transport of hydrophilic compounds using water-in-oil nanoemulsions
    H Wu
    Department of Pharmaceutics, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA
    Int J Pharm 220:63-75. 2001
    ....
  81. ncbi The effect of oil components on the physicochemical properties and drug delivery of emulsions: tocol emulsion versus lipid emulsion
    Chi Feng Hung
    School of Medicine, Fu Jen Catholic University, Taipei, Taiwan
    Int J Pharm 335:193-202. 2007
    ..The inclusion of resveratrol into the emulsions and aqueous micelles retarded the drug release...
  82. ncbi Effect of self-microemulsifying drug delivery systems containing Labrasol on tight junctions in Caco-2 cells
    Xianyi Sha
    Department of Pharmaceutics, School of Pharmacy, Fudan University, No 138 Yixueyuan Road, Shanghai 200032, China
    Eur J Pharm Sci 24:477-86. 2005
    ..1 and 1% was shown to increase the permeability of mannitol by 4.6-fold and 33.8-fold, respectively. The mechanism of opening of tight junctions was found to involve F-actin-related changes and redistribution of ZO-1...
  83. ncbi Optical properties of fat emulsions
    Rene Michels
    Institut fur Lasertechnologien in der Medizin und Messtechnik, Helmholtzstr 12, D 89081 Ulm, Germany
    Opt Express 16:5907-25. 2008
    We present measurements of the optical properties of six different fat emulsions from three different brands, Clinoleic, Lipovenoes and Intralipid, with fat concentrations from 10% to 30%...
  84. doi Physicochemical characterization and biological activity of synthetic TLR4 agonist formulations
    Ryan C Anderson
    Infectious Disease Research Institute, 1124 Columbia St, Ste 400, Seattle, WA 98104, USA
    Colloids Surf B Biointerfaces 75:123-32. 2010
    ..ratios than aqueous formulations or an emulsion formulation without the agonist, and (3) appropriate plant-derived components can be substituted for animal-derived components in oil-in-water emulsions without loss of biological activity.
  85. ncbi In vitro adsorption of plasma proteins onto the surface (charges) modified-submicron emulsions for intravenous administration
    Shunmugaperumal Tamilvanan
    Department of Pharmaceutics, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel
    Eur J Pharm Biopharm 59:1-7. 2005
    Surface (charge) modified submicron emulsions (cationic and anionic) were prepared following the well established combined emulsification techniques and characterized for their droplet size distribution and surface charge...
  86. ncbi Biodegradable microparticles for sustained delivery of tetracycline to the periodontal pocket: formulatory and drug release studies
    E Esposito
    Department of Pharmaceutical Sciences, Ferrara University, Italy
    J Microencapsul 14:175-87. 1997
    ..Only DL-PLG microparticles showed significant changes in their morphology, whereas L-PLA and DL-PLA were found almost intact after the same period of time...
  87. ncbi Novel microemulsion enhancer formulation for simultaneous transdermal delivery of hydrophilic and hydrophobic drugs
    Philp J Lee
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Pharm Res 20:264-9. 2003
    ..Microemulsion (ME) systems allow for the microscopic co-incorporation of aqueous and organic phase liquids. In this study, the phase diagrams of four novel ME systems were characterized...
  88. pmc PCR amplification from single DNA molecules on magnetic beads in emulsion: application for high-throughput screening of transcription factor targets
    Takaaki Kojima
    Laboratory of Molecular Biotechnology, Graduate School of Bioagricultural Sciences, Nagoya University Furo cho, Chikusa ku, Nagoya 464 8601, Japan
    Nucleic Acids Res 33:e150. 2005
    ..on solid-phase single-molecule PCR in a fine and robust water-phase compartment formed in water-in-oil (w/o) emulsions. In this method, critically diluted DNA fragments were distributed over the emulsion as templates, where beads ..
  89. ncbi Preparation and evaluation of SEDDS and SMEDDS containing carvedilol
    Lanlan Wei
    Department of Pharmaceutics, Shen Yang Pharmaceutical University, Shen Yang, P R China
    Drug Dev Ind Pharm 31:785-94. 2005
    ..The developed SEDDS formulations significantly improved the oral bioavailability of carvedilol significantly, and the relative oral bioavailability of SEDDS compared with commercially available tablets was 413%...
  90. doi Nasal immunization with a recombinant HIV gp120 and nanoemulsion adjuvant produces Th1 polarized responses and neutralizing antibodies to primary HIV type 1 isolates
    Anna U Bielinska
    Michigan Nanotechnology Institute for Medicine and Biological Sciences MNIMBS, University of Michigan, Ann Arbor, Michigan 48109, USA
    AIDS Res Hum Retroviruses 24:271-81. 2008
    ..This study suggests that NE should be evaluated as a mucosal adjuvant for multivalent HIV vaccines...
  91. ncbi Peroxisome proliferator-activated receptor-gamma coactivator-1 and insulin resistance: acute effect of fatty acids
    J Hoeks
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Diabetologia 49:2419-26. 2006
    ..We examined whether lipid-induced insulin resistance was associated with downregulation of expression of skeletal muscle genes involved in oxidative metabolism and mitochondrial biogenesis in humans...
  92. ncbi Evaluation in melanoma-bearing mice of an etoposide derivative associated to a cholesterol-rich nano-emulsion
    Ana C Lo Prete
    Faculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    J Pharm Pharmacol 58:801-8. 2006
    ..The incorporation of etoposide oleate to LDE resulted in markedly reduced toxicity and superior antitumoral activity. LDE-etoposide oleate is a promising new weapon for cancer treatment...
  93. ncbi Lipid nanoparticles for skin penetration enhancement-correlation to drug localization within the particle matrix as determined by fluorescence and parelectric spectroscopy
    S Lombardi Borgia
    Institut fur Pharmazie, Freie Universitat Berlin, Germany
    J Control Release 110:151-63. 2005
    ..Therefore, drug targeting appears to be more strictly related to the mode of interaction of drug and particle than penetration enhancement...
  94. doi The universality of low-energy nano-emulsification
    Nicolas Anton
    CNRS 7199, Universite de Strasbourg, Faculte de Pharmacie, Laboratoire de Conception et Application de Molecules Bioactives, équipe de Pharmacie Biogalénique, 74 route du Rhin BP 60024 F 67401 Illkirch Cedex, France
    Int J Pharm 377:142-7. 2009
    Extensive studies have been done on nano-emulsions and emulsification methods to provide nanometric-scaled templates for the formulation of nanoparticles...
  95. ncbi Cremophor-free intravenous microemulsions for paclitaxel I: formulation, cytotoxicity and hemolysis
    Adwoa O Nornoo
    Department of Pharmaceutical Sciences, Albany College of Pharmacy, Albany, NY 12208, USA
    Int J Pharm 349:108-16. 2008
    ..This higher drug loading results in a smaller vehicle volume in required doses of these formulations and potentially less vehicle-related side effects are anticipated...
  96. ncbi Enhanced nuclear delivery and cytotoxic activity of hydroxycamptothecin using o/w emulsions
    Yongxing Zhao
    College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, PR China
    J Pharm Pharm Sci 10:61-70. 2007
    Hydroxycamptothecin-Emulsions (HCPT-E), being a promising delivery system for intravenous applications, were prepared. Here we evaluated the relation of cytotoxicity and intracellular drug amounts...
  97. ncbi Transdermal delivery of capsaicin derivative-sodium nonivamide acetate using microemulsions as vehicles
    Yaw Bin Huang
    Graduate Institute of Clinical Pharmacy, Kaohsiung Medical University, 100 Shih Chuan 1st Road, Kaohsiung City 80708, Taiwan
    Int J Pharm 349:206-11. 2008
    ..2 buffer containing 25% ethanol) reported in an earlier study, therefore microemulsions could be an effective vehicle for topical delivery of SNA...
  98. ncbi Microemulsions with timolol as potential eye drops
    I Malina
    Department of Pharmaceutical Technology, Karol Marcinkowski University of Medical Sciences, 6, Grunwaldzka Str, 60 780 Poznan, Poland
    Pharmazie 61:650-1. 2006
    ..The following physical parameters were investigated: density, dynamic viscosity, refractive index, surface tension, pH and osmotic tension. All the microemulsions met the requirements for eye drops...
  99. doi Development of microemulsions to topically deliver 5-aminolevulinic acid in photodynamic therapy
    Luciana Mattoso Pires de Campos Araújo
    Department of Pharmaceutical Sciences, University of Sao Paulo, Ribeirao Preto, Brazil
    Eur J Pharm Biopharm 75:48-55. 2010
    ..The microemulsion developed carried 5-ALA to the deeper skin layers, increasing the red fluorescence of the skin and indicating the potentiality of the system for topical 5-ALA-PDT...
  100. ncbi Applications of microemulsion based drug delivery system
    K R Jadhav
    Department of Pharmaceutics, Bharati Vidyapeeth s College of Pharmacy, CBD Belapur, Sector 8, Navi Mumbai 400614, India
    Curr Drug Deliv 3:267-73. 2006
    ....
  101. ncbi An alternative paclitaxel microemulsion formulation: hypersensitivity evaluation and pharmacokinetic profile
    Lei He
    Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing 100083, People s Republic of China
    Int J Pharm 250:45-50. 2003
    ..29 h(-1)), showing the elimination rate was much slower in the former than in the latter. Compared with Taxol, the paclitaxel microemulsion caused less toxicity and had a longer circulation time in rats...

Research Grants78

  1. Long Chain Fatty Acid (LCFA) Taste Receptor CD36 in Food Choice and Consumption
    Eric Walters; Fiscal Year: 2007
    ..We will evaluate simple oil/water emulsions, dairy, and soy milk based beverages so that we can present palatable samples which will not provide olfactory ..
  2. Sub-micrometer zero valent metal for in-situ remediation of contaminated aquifers
    JOHN FREIM; Fiscal Year: 2007
    ..The Phase I work will conclude by making zero valent metal-containing water in oil emulsions that can accomplish the in-situ remediation of non aqueous phase contaminants...
  3. METABOLISM OF INTRAVENOUS LIPID EMULSIONS
    Richard Deckelbaum; Fiscal Year: 2007
    ..of this research program is to characterize how specific types of triglycerides (TG) in intravenous (IV) lipid emulsions affect particle metabolism and impact upon the biological potentials of their component lipids...
  4. Cholestasis Reversal (Phase ll): Efficacy of lV Fish Oil
    Mark Puder; Fiscal Year: 2010
    ..Studies suggest that soybean oil containing intravenous fat emulsions (IFE) may be a major contributing factor...
  5. DCTD Human Toxicology and Pharmacology
    LARRY ARTHUR; Fiscal Year: 2010
    ..is formulation testing of NCEs in novel pharmaceutical technology platforms, such as nanodispersions and emulsions, targeted nano-particles, and targeted carrier proteins...
  6. DCTD Human Toxicology and Pharmacology
    David Heimbrook; Fiscal Year: 2011
    ..is formulation testing of NCEs in novel pharmaceutical technology platforms, such as nanodispersions and emulsions, targeted nano-particles, and targeted carrier proteins...
  7. DCTD Human Toxicology and Pharmacology
    David Heimbrook; Fiscal Year: 2012
    ..is formulation testing of NCEs in novel pharmaceutical technology platforms, such as nanodispersions and emulsions, targeted nano-particles, and targeted carrier proteins...
  8. DCTD Human Toxicology and Pharmacology
    LARRY ARTHUR; Fiscal Year: 2009
    ..is formulation testing of NCEs in novel pharmaceutical technology platforms, such as nanodispersions and emulsions, targeted nano-particles, and targeted carrier proteins...
  9. PHYSIOLOGY OF FLUOROCARBON OXYGEN TRANSPORT
    LELAND CLARK; Fiscal Year: 1992
    New high capacity fluorocarbon emulsions will be tested for their ability to increase brain oxygen availability. The emulsions will be administered intravenously to rabbits having implanted oxygen, hydrogen, glucose, and lactate sensors...
  10. PHYSIOLOGY OF FLUOROCARBON OXYGEN TRANSPORT
    LELAND CLARK; Fiscal Year: 1990
    New high capacity fluorocarbon emulsions will be tested for their ability to increase brain oxygen availability. The emulsions will be administered intravenously to rabbits having implanted oxygen, hydrogen, glucose, and lactate sensors...
  11. ORAL DRUG DELIVERY AND BIOAVAILABILITY--AIDS
    Gordon Amidon; Fiscal Year: 1993
    ..and furosemide or nadolol; (2) extend the transport model for drug dissolution into surfactant solutions to emulsions and apply this model to estimating the extend of drug absorption for water insoluble drugs in humans; (3) ..
  12. Nanoemulsion-based vaccine for chronic hepatitis B virus
    James R Baker; Fiscal Year: 2010
    ..Nanoemulsion adjuvants are oil-in-water emulsions prepared by high speed homogenization using innocuous surfactants and solvents as stabilizers with an average ..
  13. Antibacterial, antifungal, antiviral, and antispore paints
    YUYU contact SUN; Fiscal Year: 2010
    ..tetramethyl-4-piperidinyl acrylate (Cl-TMPA), will be polymerized to produce polymeric N-halamine latex emulsions. On adding a small amount of such emulsions into conventional water-based latex paint, the new paint will be ..
  14. Antibacterial, antifungal, antiviral, and antispore paints
    YUYU contact SUN; Fiscal Year: 2011
    ..tetramethyl-4-piperidinyl acrylate (Cl-TMPA), will be polymerized to produce polymeric N-halamine latex emulsions. On adding a small amount of such emulsions into conventional water-based latex paint, the new paint will be ..
  15. Red Blood Cell Mimics
    Joseph M DeSimone; Fiscal Year: 2010
    ..Previous approaches for the design of synthetic blood have focused on i) fluorocarbon emulsions which can dissolve large amounts of blood gases;ii) PEGylated hemoglobin;and iii) liposomal delivery of ..
  16. Molecular Mechanisms of Dietary Fat Digestion by Pancreatic Lipases
    Mark Lowe; Fiscal Year: 2009
    ..identified critical residues in PTL-colipase and PLRP2 that influence the absorption of these lipases to lipid emulsions. 3) Comparison and preliminary analysis of the structures of PTL and PLRP2 identified domains that can mediate ..
  17. Molecular Mechanisms of Dietary Fat Digestion by Pancreatic Lipases
    Mark E Lowe; Fiscal Year: 2010
    ..identified critical residues in PTL-colipase and PLRP2 that influence the absorption of these lipases to lipid emulsions. 3) Comparison and preliminary analysis of the structures of PTL and PLRP2 identified domains that can mediate ..
  18. Biomimetic Approach to the Fabrication of Red Blood Cell Mimics
    Joseph M DeSimone; Fiscal Year: 2010
    ..Previous approaches for the design of synthetic blood have focused on i) fluorocarbon emulsions which can dissolve large amounts of blood gases;ii) PEGylated hemoglobin;and iii) liposomal delivery of ..
  19. Biomimetic Approach to the Fabrication of Red Blood Cell Mimics
    Joseph DeSimone; Fiscal Year: 2009
    ..Previous approaches for the design of synthetic blood have focused on i) fluorocarbon emulsions which can dissolve large amounts of blood gases;ii) PEGylated hemoglobin;and iii) liposomal delivery of ..
  20. EFFECT OF ELECTROLYTES ON NONIONIC SURFACTANTS
    HANS SCHOTT; Fiscal Year: 1980
    ..by electrolytes even at low salt or acid concentrations: suspensions are flocculated or their sediments cake, emulsions and ointments separate, and insoluble drugs solubilized in micelles precipitate...
  21. Cholestasis Prevention: Efficacy of IV Fish Oil
    Mark Puder; Fiscal Year: 2009
    ..Studies suggest that soybean oil containing intravenous fat emulsions (IFE) may be a major contributing factor...
  22. RADIOPAQUE FLUOROCARBON IN DIAGNOSTIC RADIOLOGY
    David Long; Fiscal Year: 1980
    ..Experiments with RFC in lymphography have been completed and humans studies will be started soon. Emulsions of RFC have been perfected so that large quantities can be given safely intravenously...
  23. APOE3 AND APOE4 EFFECTS ON CELLULAR PATHOBIOLOGY
    ROBERT PITAS; Fiscal Year: 1999
    ..Only apoE added to the cell with beta- migrating very low density lipoproteins (beta-VLDL) or lipid emulsions had an effect, and the effect was blocked by reductive methylation of apoE or by antibodies to the receptor-..
  24. Cholestasis Reversal (Phase ll): Efficacy of lV Fish Oil
    Mark Puder; Fiscal Year: 2009
    ..Studies suggest that soybean oil containing intravenous fat emulsions (IFE) may be a major contributing factor...
  25. METABOLIC ROLE OF VITAMIN E: CLINICAL & CELLULAR STUDIES
    Herbert Kayden; Fiscal Year: 1991
    ..The widespread use of total parenteral nutrition and intravenous lipid emulsions warrants the examination of the role of tocopherol in the protection of the fatty acids of the intravenous ..
  26. The Essentiality of Arachidonic Acid (AA), Docosahexaenoic Acid (DHA)
    Erica M Fallon; Fiscal Year: 2010
    ..This information will set the groundwork for the creation of non-toxic lipid emulsions for infants and children...
  27. ADHESINS OF COAGULASE-NEGATIVE STAPHYLOCOCCI
    Gerald Pier; Fiscal Year: 1990
    ..suggested by recent epidemiologic investigations which strongly implicate intravenous administration of lipid emulsions as a major co-factor in dramatically increasing the risk for catheter-associated coagulase-negative ..
  28. DRUG AND METABOLIC STUDIES OF PULMONARY FAT EMBOLISM
    STANLEY SHERR; Fiscal Year: 1980
    ..We shall use a model system developed in our laboratory in which injected labelled triglyceride emulsions accumulate in the vascular bed of the lung...
  29. PHOSPHORIMAGER
    Allan Brasier; Fiscal Year: 1993
    ..Even under optimized conditions to enhance sensitivity of detection by film emulsions, X-ray film demonstrates a narrow range of linear response...
  30. Genetic circuits based on allosteric ribozymes
    Andrew Ellington; Fiscal Year: 2006
    ..reactions using a novel trans-selection method based on in vitro compartmentalization (IVC) in water-in-oil emulsions. The fastest aptazymes will then be further screened for function in E. coli cells...
  31. Genetic circuits based on allosteric ribozymes
    Andrew Ellington; Fiscal Year: 2007
    ..reactions using a novel trans-selection method based on in vitro compartmentalization (IVC) in water-in-oil emulsions. The fastest aptazymes will then be further screened for function in E. coli cells...
  32. Genetic circuits based on allosteric ribozymes
    Andrew D Ellington; Fiscal Year: 2010
    ..reactions using a novel trans-selection method based on in vitro compartmentalization (IVC) in water-in-oil emulsions. The fastest aptazymes will then be further screened for function in E. coli cells...
  33. Genetic circuits based on allosteric ribozymes
    Andrew Ellington; Fiscal Year: 2009
    ..reactions using a novel trans-selection method based on in vitro compartmentalization (IVC) in water-in-oil emulsions. The fastest aptazymes will then be further screened for function in E. coli cells...
  34. Parenteral Medium Chain Triglycerides in the Premature
    Eberhard Schmidt Sommerfeld; Fiscal Year: 2002
    ..MCT-containing lipid emulsions are being studied in adults. No studies in premature infants have been reported in the U.S...
  35. Parenteral Medium Chain Triglycerides in the Premature
    Eberhard Schmidt Sommerfeld; Fiscal Year: 2001
    ..MCT-containing lipid emulsions are being studied in adults. No studies in premature infants have been reported in the U.S...
  36. Project 3-Mechanism of Leukotriene Inhibition by Oils
    FLOYD CHILTON; Fiscal Year: 2005
    ..e.borage oil emulsions) can be determined, if other botanical oils can safely substitute for oils that contain EPA to enhance ..
  37. SUPERHEATED DROP DETECTORS FOR DOSIMETRY IN RADIOTHERAPY
    Ravinder Nath; Fiscal Year: 2000
    ..Specifically, we propose: (1) to improve the photon energy response of the SEC by using emulsions containing only elements with tissue-like atomic numbers; (2) to optimize the speed of image acquisition and ..
  38. SUPERHEATED DROP DETECTORS FOR DOSIMETRY IN RADIOTHERAPY
    Ravinder Nath; Fiscal Year: 1999
    ..Specifically, we propose: (1) to improve the photon energy response of the SEC by using emulsions containing only elements with tissue-like atomic numbers; (2) to optimize the speed of image acquisition and ..
  39. SUPERHEATED DROP DETECTORS FOR DOSIMETRY IN RADIOTHERAPY
    Ravinder Nath; Fiscal Year: 2001
    ..Specifically, we propose: (1) to improve the photon energy response of the SEC by using emulsions containing only elements with tissue-like atomic numbers; (2) to optimize the speed of image acquisition and ..
  40. LIPOPROTEIN LIPASE MODULATION OF TISSUE LIPID UPTAKE
    JOSEPH OBUNIKE; Fiscal Year: 1999
    ..Studies which I performed showed that LPL increased uptake of low density lipoprotein (LDL) and lipid-emulsions by fibroblasts and THP-1 macrophages...
  41. Injectable, High Porosity Bone Scaffolds by Emulsion Templating
    ELIZABETH MARIE COSGRIFF HERNANDEZ; Fiscal Year: 2010
    ..for the production of highly porous scaffolds and involves the template polymerization of high internal phase emulsions (HIPEs)...
  42. ACAT REACTIVITY IN MACROPHAGES
    Ira Tabas; Fiscal Year: 1992
    ..will be to determine the effect of apo E depletion, repletion, and modification of Beta-VLDL particles and lipid emulsions on patterns of endocytosis and ACAT stimulation...
  43. PERFLUOROCHEMICAL EMULSIONS AS ADJUNCTS TO RADIOTHERAPY
    Sara Rockwell; Fiscal Year: 1990
    ..The exceptional O2-carrying capacity of perfluorochemicals has provided the basis for using physiolologic emulsions of perfluorochemicals as O2-transport fluids after hemorrhage or during surgery when blood transfusions are ..
  44. ALIMENTARY TRACT LIPIDS IN HEALTH AND DISEASE
    Martin Carey; Fiscal Year: 1991
    ..and non-micellar particles, as will their fate when diluted and mixed with pancreatic enzymes and dietary fat emulsions. Cholesterol nucleation and crystallization from bile will be investigated with particular reference to bile ..
  45. METABOLISM OF INTRAVENOUS LIPID EMULSIONS
    Richard Deckelbaum; Fiscal Year: 1992
    The objective of this proposal is to elucidate the mechanisms whereby intravenous lipid emulsions, a commonly used energy substrate in patients requiring parenteral nutrition, deliver their triglyceride to cells, and once internalized, ..
  46. VASCULAR BUBBLE GENERATION FOR DIAGNOSIS AND THERAPY
    PAUL CARSON; Fiscal Year: 2007
    ..by bubbles from intra-arterial droplet injections to occlusion by bubbles from intravenous injections of droplet emulsions. After achieving the generation of necessary bubble concentrations from transpulmonary droplets, similar copious ..
  47. T CELL IMMUNITY AND SYNTHETIC PEPTIDE AIDS VACCINES
    Amnon Altman; Fiscal Year: 1990
    ..coli as immunological adjuvants that can bypass the need for oil emulsions and other unacceptable adjuvants...
  48. T CELL IMMUNITY AND SYNTHETIC PEPTIDE AIDS VACCINES
    Amnon Altman; Fiscal Year: 1991
    ..coli as immunological adjuvants that can bypass the need for oil emulsions and other unacceptable adjuvants...
  49. VASCULAR BUBBLE GENERATION FOR DIAGNOSIS AND THERAPY
    PAUL CARSON; Fiscal Year: 2006
    ..by bubbles from intra-arterial droplet injections to occlusion by bubbles from intravenous injections of droplet emulsions. After achieving the generation of necessary bubble concentrations from transpulmonary droplets, similar copious ..
  50. VASCULAR BUBBLE GENERATION FOR DIAGNOSIS AND THERAPY
    PAUL CARSON; Fiscal Year: 2005
    ..by bubbles from intra-arterial droplet injections to occlusion by bubbles from intravenous injections of droplet emulsions. After achieving the generation of necessary bubble concentrations from transpulmonary droplets, similar copious ..
  51. Parenteral Formulations for Synthetic Retinoids
    Ralph Parchment; Fiscal Year: 2001
    ..The Pharmacology Core at Wayne State University found that novel co-polymer mixtures or lipid emulsions may be suitable IV carriers for fenretinide that may be useful to exceed the apparent saturable absorption ..
  52. Droplet Method for Bilayer Assays
    Gregory W Faris; Fiscal Year: 2010
    ..investigate the inverted emulsion method for membrane proteins by: (1) studying bilayer formation in an inverted emulsions by characterizing the bilayer performance with respect to the continuous phase and lipid composition and phase ..
  53. In Vivo Cellular and Molecular Imaging Centers (ICMICs)
    Robert Mattrey; Fiscal Year: 2009
    ..This project aims to bring to ultrasound the ability to detect enzymes. We have successfully produced emulsions and nanobubbles with particles less than 100nm that are capable of exiting the vascular space...
  54. Enzyme Detection with Ultrasound Contrast Agents
    Robert F Mattrey; Fiscal Year: 2011
    ..This project aims to bring to ultrasound the ability to detect enzymes. We have successfully produced emulsions and nanobubbles with particles less than 100nm that are capable of exiting the vascular space...
  55. Droplet Method for Bilayer Assays
    GREGORY FARIS; Fiscal Year: 2009
    ..investigate the inverted emulsion method for membrane proteins by: (1) studying bilayer formation in an inverted emulsions by characterizing the bilayer performance with respect to the continuous phase and lipid composition and phase ..
  56. CADMIUM-113 NMR OF SYSTEMS OF BIOLOGICAL INTEREST
    Paul Ellis; Fiscal Year: 1990
    ..circumvent this "problem" we propose to study cadmium's nmr parameters in the liquid state, supercooled aqueous emulsions, and in the solid state...
  57. ISOLATED HEART PERFUSION WITH PERFLUOROCHEMICAL EMULSION
    LEIGH SEGEL; Fiscal Year: 1991
    ..the biochemical and physiological mechanisms underlying the efficacy and biocompatibility, of fluorochemical emulsions. The proposed work continues our investigation of long-term hypothermic cardiac preservation using APE-LM, a ..
  58. Early Events in Lipoprotein Assembly
    CHRISTOPHER MCKNIGHT; Fiscal Year: 2009
    ..fragments of ApoS in a cell free system supplemented with phospholipids and phospholipid-triacylglycerol emulsions to test the hypothesis that cotranslational interaction of ApoS with lipids is spontaneous and essential for the ..
  59. METABOLISM OF INTRAVENOUS LIPID EMULSIONS
    Richard Deckelbaum; Fiscal Year: 2003
    Our objective is to characterize pathways whereby intravenous (IV) lipid emulsions, commonly used clinically as nutritional support, deliver specific types of triglyceride (TG) to tissues and cells...
  60. METABOLISM OF INTRAVENOUS LIPID EMULSIONS
    Richard Deckelbaum; Fiscal Year: 2006
    Our objective is to characterize pathways whereby intravenous (IV) lipid emulsions, commonly used clinically as nutritional support, deliver specific types of triglyceride (TG) to tissues and cells...
  61. METABOLISM OF INTRAVENOUS LIPID EMULSIONS
    Richard Deckelbaum; Fiscal Year: 2004
    Our objective is to characterize pathways whereby intravenous (IV) lipid emulsions, commonly used clinically as nutritional support, deliver specific types of triglyceride (TG) to tissues and cells...
  62. METABOLISM OF INTRAVENOUS LIPID EMULSIONS
    Richard Deckelbaum; Fiscal Year: 2005
    Our objective is to characterize pathways whereby intravenous (IV) lipid emulsions, commonly used clinically as nutritional support, deliver specific types of triglyceride (TG) to tissues and cells...