vitamin k 1

Summary

Summary: A family of phylloquinones that contains a ring of 2-methyl-1,4-naphthoquinone and an isoprenoid side chain. Members of this group of vitamin K 1 have only one double bond on the proximal isoprene unit. Rich sources of vitamin K 1 include green plants, algae, and photosynthetic bacteria. Vitamin K1 has antihemorrhagic and prothrombogenic activity.

Top Publications

  1. ncbi Supplementation of rats with a lutein mixture preserved with vitamin E reduces tissue phylloquinone and menaquinone-4
    G V Mitchell
    Office of Nutritional Products, Labeling and Dietary Supplements, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA
    Int J Vitam Nutr Res 71:30-5. 2001
  2. ncbi Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7
    Leon J Schurgers
    VitaK and Cardiovascular Research Institute Maastricht, University of Maastricht, 6200 MD Maastricht, The Netherlands
    Blood 109:3279-83. 2007
  3. ncbi Comparison of various phytonadione (vitamin K1) administration routes in achieving warfarin reversal
    Brad Laible
    South Dakota State University College of Pharmacy, Avera McKennan Hospital, Sioux Falls, USA
    S D Med 60:158-9. 2007
  4. ncbi Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials
    Sarah Cockayne
    York Trials Unit, Department of Health Sciences, University of York, York YO10 5DD, England
    Arch Intern Med 166:1256-61. 2006
  5. ncbi Novel role of vitamin k in preventing oxidative injury to developing oligodendrocytes and neurons
    Jianrong Li
    Department of Neurology, Division of Neuroscience, Children s Hospital, Boston, MA 02115, USA
    J Neurosci 23:5816-26. 2003
  6. pmc CYP4F2 is a vitamin K1 oxidase: An explanation for altered warfarin dose in carriers of the V433M variant
    Matthew G McDonald
    Department of Medicinal Chemistry, University of Washington, Seattle, 98195, USA
    Mol Pharmacol 75:1337-46. 2009
  7. doi The vitamin K cycle
    Johannes Oldenburg
    Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, D 53105 Bonn, Germany
    Vitam Horm 78:35-62. 2008
  8. ncbi Conversion of phylloquinone (Vitamin K1) into menaquinone-4 (Vitamin K2) in mice: two possible routes for menaquinone-4 accumulation in cerebra of mice
    Toshio Okano
    Department of Hygienic Sciences, Kobe Pharmaceutical University, 4 19 1, Motoyamakita machi, Higashinada ku, Kobe 658 8558, Japan
    J Biol Chem 283:11270-9. 2008
  9. ncbi Cytotoxic activity of vitamins K1, K2 and K3 against human oral tumor cell lines
    H Okayasu
    Department of Dental Pharmacology, Meikai University School of Dentistry, Sakado, Saitama, Japan
    Anticancer Res 21:2387-92. 2001
  10. pmc Vitamin K, circulating cytokines, and bone mineral density in older men and women
    M Kyla Shea
    US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Am J Clin Nutr 88:356-63. 2008

Research Grants

Detail Information

Publications210 found, 100 shown here

  1. ncbi Supplementation of rats with a lutein mixture preserved with vitamin E reduces tissue phylloquinone and menaquinone-4
    G V Mitchell
    Office of Nutritional Products, Labeling and Dietary Supplements, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA
    Int J Vitam Nutr Res 71:30-5. 2001
    ..The presence of other components in the supplement confounded the interpretation of the biological effects of lutein alone on vitamin K metabolism...
  2. ncbi Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7
    Leon J Schurgers
    VitaK and Cardiovascular Research Institute Maastricht, University of Maastricht, 6200 MD Maastricht, The Netherlands
    Blood 109:3279-83. 2007
    ..MK-7 induced more complete carboxylation of osteocalcin, and hematologists should be aware that preparations supplying 50 mug/d or more of MK-7 may interfere with oral anticoagulant treatment in a clinically relevant way...
  3. ncbi Comparison of various phytonadione (vitamin K1) administration routes in achieving warfarin reversal
    Brad Laible
    South Dakota State University College of Pharmacy, Avera McKennan Hospital, Sioux Falls, USA
    S D Med 60:158-9. 2007
  4. ncbi Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials
    Sarah Cockayne
    York Trials Unit, Department of Health Sciences, University of York, York YO10 5DD, England
    Arch Intern Med 166:1256-61. 2006
    ..Observational and some experimental data suggest that low intake of vitamin K may be associated with an increased risk of fracture...
  5. ncbi Novel role of vitamin k in preventing oxidative injury to developing oligodendrocytes and neurons
    Jianrong Li
    Department of Neurology, Division of Neuroscience, Children s Hospital, Boston, MA 02115, USA
    J Neurosci 23:5816-26. 2003
    ....
  6. pmc CYP4F2 is a vitamin K1 oxidase: An explanation for altered warfarin dose in carriers of the V433M variant
    Matthew G McDonald
    Department of Medicinal Chemistry, University of Washington, Seattle, 98195, USA
    Mol Pharmacol 75:1337-46. 2009
    ..Therefore, patients with the rs2108622 polymorphism are likely to have elevated hepatic levels of VK1, necessitating a higher warfarin dose to elicit the same anticoagulant response...
  7. doi The vitamin K cycle
    Johannes Oldenburg
    Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, D 53105 Bonn, Germany
    Vitam Horm 78:35-62. 2008
    ....
  8. ncbi Conversion of phylloquinone (Vitamin K1) into menaquinone-4 (Vitamin K2) in mice: two possible routes for menaquinone-4 accumulation in cerebra of mice
    Toshio Okano
    Department of Hygienic Sciences, Kobe Pharmaceutical University, 4 19 1, Motoyamakita machi, Higashinada ku, Kobe 658 8558, Japan
    J Biol Chem 283:11270-9. 2008
    ....
  9. ncbi Cytotoxic activity of vitamins K1, K2 and K3 against human oral tumor cell lines
    H Okayasu
    Department of Dental Pharmacology, Meikai University School of Dentistry, Sakado, Saitama, Japan
    Anticancer Res 21:2387-92. 2001
    ....
  10. pmc Vitamin K, circulating cytokines, and bone mineral density in older men and women
    M Kyla Shea
    US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Am J Clin Nutr 88:356-63. 2008
    ..Vitamin K modulates cytokines involved in bone turnover, including interleukin-6 (IL-6) and osteoprotegerin in vitro...
  11. ncbi Pharmacokinetics and efficacy of oral versus intravenous mixed-micellar phylloquinone (vitamin K1) in severe acute liver disease
    Stephen P Pereira
    Institute of Liver Studies, King s College Hospital, London, UK
    J Hepatol 42:365-70. 2005
    ..However, there have been no studies of the pharmacokinetics or efficacy of i.v. or oral K1 in such patients...
  12. ncbi Dietary phylloquinone intakes and metabolic syndrome in US young adults
    Yang Pan
    The Coca Cola Company, Global Scientific and Regulatory Affairs, 2150 Town Square Place, Suite 400, Room A6111, Sugar Land, TX 77479, USA
    J Am Coll Nutr 28:369-79. 2009
    ..The aim of this study was to examine whether and to what extent vitamin K intake measured as phylloquinone is related to MetS...
  13. pmc Effect of phylloquinone supplementation on glucose homeostasis in humans
    Rajiv Kumar
    Nephrology Research Unit, Divisions of Nephrology and Hypertension and the Division of Endocrinology and Metabolism, Department of Medicine, Mayo Clinic, Rochester, MN, USA
    Am J Clin Nutr 92:1528-32. 2010
    ..Under-γ-carboxylated osteocalcin (ucOC) increases insulin secretion and decreases glucose concentrations in mice...
  14. doi The external quality assurance of phylloquinone (vitamin K(1)) analysis in human serum
    David J Card
    The Centre for Haemostasis and Thrombosis Nutristasis Unit, Guy s and St Thomas NHS Foundation Trust, London, UK
    Biomed Chromatogr 23:1276-82. 2009
    ..The high proportion of false positive results suggest that poor assay specificity at low phylloquinone concentrations is a common problem, which in the clinical setting could lead to underreporting of vitamin K deficiency...
  15. doi Dietary phylloquinone intake and risk of type 2 diabetes in elderly subjects at high risk of cardiovascular disease
    Núria Ibarrola-Jurado
    Human Nutrition Unit, Faculty of Medicine and Health Sciences, Institute of Health Research Pere Virgli, Universitat Rovira i Virgili, Reus, Spain
    Am J Clin Nutr 96:1113-8. 2012
    ..Limited evidence from human and animal studies has suggested that vitamin K has a potentially beneficial role in glucose metabolism and insulin resistance...
  16. doi c-Met-Akt pathway-mediated enhancement of inhibitory c-Raf phosphorylation is involved in vitamin K1 and sorafenib synergy on HCC growth inhibition
    Brian I Carr
    De Bellis Medical Research Institute, Castellana Grotte, Italy
    Cancer Biol Ther 12:531-8. 2011
    ....
  17. ncbi Naturally occurring K vitamins inhibit pancreatic cancer cell survival through a caspase-dependent pathway
    Shayna L Showalter
    Department of Surgery, Jefferson Center for Pancreatic, Biliary and Related Cancers, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Gastroenterol Hepatol 25:738-44. 2010
    ..We hypothesized that the well-tolerated and naturally occurring VK1 and VK2 may be used to inhibit pancreatic cancer cell survival...
  18. ncbi Determination of phylloquinone and menaquinones in animal products with fluorescence detection after postcolumn reduction with metallic zinc
    T J Koivu-Tikkanen
    Department of Applied Chemistry and Microbiology, University of Helsinki, P O Box 27, FIN 00014 University of Helsinki, Finland
    J Agric Food Chem 48:6325-31. 2000
    ..The total vitamin K contents calculated as the sum of quantified K vitamers were in general low (mean content 10-100 ng/g); the highest amount was analyzed in chicken meat (600 ng/g)...
  19. ncbi A stable isotope method for the simultaneous measurement of vitamin K1 (phylloquinone) kinetics and absorption
    K S Jones
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK
    Eur J Clin Nutr 62:1273-81. 2008
    ..To measure uptake and disposal kinetics and absolute absorption of vitamin K(1) using two stable isotope-labelled forms of vitamin K(1)...
  20. pmc Genetic and non-genetic correlates of vitamins K and D
    M K Shea
    USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Eur J Clin Nutr 63:458-64. 2009
    ..To assess the genetic and nongenetic correlates of circulating measures of vitamins K and D status in a community-based sample of men and women...
  21. pmc Gamma-carboxylation of osteocalcin and insulin resistance in older men and women
    M Kyla Shea
    USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 90:1230-5. 2009
    ..In vitro and animal studies indicate that high uncarboxylated osteocalcin is associated with reduced insulin resistance. However, associations between osteocalcin and measures of insulin resistance in humans are less clear...
  22. doi Elucidation of the mechanism producing menaquinone-4 in osteoblastic cells
    Yoshitomo Suhara
    Department of Hygienic Sciences, Kobe Pharmaceutical University, 4 19 1 Motoyamakita machi, Higashinada ku, Kobe 658 8558, Japan
    Bioorg Med Chem Lett 19:1054-7. 2009
    ..In this study, we studied the mechanism of MK-4's conversion with chemical techniques using deuterated analogues...
  23. doi Vitamin K-dependent carboxylation
    Kathleen L Berkner
    Department of Molecular Cardiology, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Lerner Research Institute, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Vitam Horm 78:131-56. 2008
    ..Also discussed is the role of the carboxylase in mammals and lower organisms, including the bacterial pathogen Leptospira interrogans that has acquired a VKD carboxylase by horizontal transfer...
  24. pmc Intestinal absorption of mixed micellar phylloquinone (vitamin K1) is unreliable in infants with conjugated hyperbilirubinaemia: implications for oral prophylaxis of vitamin K deficiency bleeding
    S P Pereira
    Department of Gastroenterology, The Middlesex Hospital, University College London Hospitals NHS Trust, London, UK
    Arch Dis Child Fetal Neonatal Ed 88:F113-8. 2003
    ..To compare the pharmacokinetics and efficacy of oral versus intravenous mixed micellar vitamin K prophylaxis in infants with cholestatic liver disease, a known risk factor for vitamin K deficiency bleeding...
  25. pmc Dietary phylloquinone and menaquinones intakes and risk of type 2 diabetes
    Joline W J Beulens
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Diabetes Care 33:1699-705. 2010
    ..To investigate whether dietary phylloquinone and menaquinones intakes are related to risk of type 2 diabetes...
  26. pmc Vitamin K3 attenuates lipopolysaccharide-induced acute lung injury through inhibition of nuclear factor-kappaB activation
    S Tanaka
    Division of Gastroenterology, Department of Internal Medicine, Graduate School of Medicine, Kobe University, Kusunoki cho, Hyogo, Japan
    Clin Exp Immunol 160:283-92. 2010
    ..Despite marked efforts, little therapeutic progress has been made, and the mortality rate of ARDS remains high. Vitamin K3 may be an effective therapeutic strategy against acute lung injury including ARDS...
  27. pmc Effect of vitamin K supplementation on bone loss in elderly men and women
    Sarah L Booth
    U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 93:1217-23. 2008
    ..Vitamin K has been implicated in bone health, primarily in observational studies. However, little is known about the role of phylloquinone supplementation on prevention of bone loss in men and women...
  28. ncbi Novel effect of vitamin K(1) (phylloquinone) and vitamin K(2) (menaquinone) on promoting nerve growth factor-mediated neurite outgrowth from PC12D cells
    Chi Kwan Tsang
    Marine and Highland Bioscience Center, Saga University, 152 1 Shonan cho, Karatsu, 847 0021, Saga, Japan
    Neurosci Lett 323:9-12. 2002
    ..These results suggest that the K vitamins enhance neurite outgrowth via the activation of PKA and MAPK-mediated signaling pathways in PC12D cells...
  29. ncbi Superwarfarin intoxication: hematuria is a major clinical manifestation
    Yi Feng Wu
    Section of Hemato Oncology, Department of Internal Medicine, Changhua Christian Hospital, No 135 Nansiao Street, Changhua City 500, Changhua County, Taiwan
    Int J Hematol 90:170-3. 2009
    ..Prolonged use of large doses of vitamin K1 is needed for the treatment of superwarfarin intoxication...
  30. ncbi Phylloquinone intake, insulin sensitivity, and glycemic status in men and women
    Makiko Yoshida
    Jean Mayer USDA Human Nutrition Research Center, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 88:210-5. 2008
    ..Limited evidence suggests that vitamin K may have a beneficial role in glucose homeostasis. No observational data exist on the associations between vitamin K intake and insulin sensitivity...
  31. doi Six weeks phylloquinone supplementation produces undesirable effects on blood lipids with no changes in inflammatory and fibrinolytic markers in postmenopausal women
    Mette Kristensen
    Dept of Human Nutrition, Centre for Advanced Food Studies, University of Copenhagen, Rolighedsvej 30, 1958, Frederiksberg C, Denmark
    Eur J Nutr 47:375-9. 2008
    ..Cardiovascular disease is the major cause of death in the Western world, but some recent studies indicate that vitamin K may play a role in atherosclerosis protection...
  32. ncbi The anticancer effects of vitamin K
    Davis W Lamson
    Coordinator of Oncology, Bastyr University, Kenmore, Washington, USA
    Altern Med Rev 8:303-18. 2003
    ..Tyrosine kinases associated with cyclins have also been shown to be affected by vitamin K, which can lead to cell cycle arrest and cell death...
  33. ncbi A high phylloquinone intake is required to achieve maximal osteocalcin gamma-carboxylation
    Neil C Binkley
    Institute on Aging, Department of Medicine, University of Wisconsin, Madison, USA
    Am J Clin Nutr 76:1055-60. 2002
    ..Dietary vitamin K is usually inadequate to maximize serum osteocalcin gamma-carboxylation. Phylloquinone supplementation increases osteocalcin gamma-carboxylation; however, the amount required to maximize carboxylation is not known...
  34. ncbi Dietary and nondietary determinants of vitamin K biochemical measures in men and women
    Nicola M McKeown
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 132:1329-34. 2002
    ..Despite these caveats, these findings support the use of a FFQ for a relative assessment of vitamin K status in population-based studies...
  35. ncbi Differential lipoprotein transport pathways of K-vitamins in healthy subjects
    Leon J Schurgers
    Department of Biochemistry and Cardiovascular Research Institute, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Biochim Biophys Acta 1570:27-32. 2002
    ..Moreover, the very long half-life time of MK-9 in the circulation indicates that it may form a more constant source of vitamin K than are either K1 or MK-4...
  36. ncbi Compilation of a provisional UK database for the phylloquinone (vitamin K1) content of foods
    C Bolton-Smith
    Cardiovascular Epidemiology Unit, University of Dundee, Ninewells Hospital and Medical School, UK
    Br J Nutr 83:389-99. 2000
    ..Within the scope of this present study, it has not been possible to address issues such as inter-sample variability, losses during storage or the bioavailability from different foods and further work on these aspects is needed...
  37. ncbi Effect of calcium fortified milk supplementation with or without vitamin K on biochemical markers of bone turnover in premenopausal women
    Marlena C Kruger
    Institute of Food, Nutrition and Human Health, Massey University, Palmerston North, New Zealand
    Nutrition 22:1120-8. 2006
    ..We compared the effect of supplementation with a fortified skimmed milk product (high calcium skim milk) with or without added phylloquinone (vitamin K(1)) on markers of bone formation and resorption in premenopausal women...
  38. ncbi Vitamin K supplementation reduces serum concentrations of under-gamma-carboxylated osteocalcin in healthy young and elderly adults
    N C Binkley
    Institute on Aging, Department of Medicine, University of Wisconsin, Madison, WI, USA
    Am J Clin Nutr 72:1523-8. 2000
    ..Subclinical vitamin K insufficiency, manifested by under-gamma-carboxylation of the bone matrix protein osteocalcin, may be common...
  39. ncbi Effect of phylloquinone supplementation on biochemical markers of vitamin K status and bone turnover in postmenopausal women
    Susanne Bugel
    Department of Human Nutrition Centre for Advanced Food Studies, The Royal Veterinary and Agricultural University, Rolighedsvej 30, DK 1958 Frederiksberg C, Denmark
    Br J Nutr 97:373-80. 2007
    ..In conclusion, while daily supplementation with 200 and 500 microg phylloquinone/d for 6 weeks increased vitamin K status in postmenopausal women, it had no effect on bone turnover...
  40. ncbi Vitamin K in the treatment and prevention of osteoporosis and arterial calcification
    Jamie Adams
    Castle Medical Center, Kailua, HI 96814, USA
    Am J Health Syst Pharm 62:1574-81. 2005
    ..The role of vitamin K in the prevention and treatment of osteoporosis and arterial calcification is examined...
  41. ncbi Vitamin K, bone turnover, and bone mass in girls
    Heidi J Kalkwarf
    Children s Hospital Medical Center, Cincinnati, USA
    Am J Clin Nutr 80:1075-80. 2004
    ..Vitamin K has been suggested to have a role in bone metabolism, and low vitamin K intake has been related to low bone density and increased risk of osteoporotic fracture...
  42. ncbi Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study
    Johanna M Geleijnse
    Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    J Nutr 134:3100-5. 2004
    ..71 (0.50, 1.00) and 0.48 (0.32, 0.71), respectively]. Phylloquinone intake was not related to any of the outcomes. These findings suggest that an adequate intake of menaquinone could be important for CHD prevention...
  43. ncbi Vitamin K and D association stimulates in vitro osteoblast differentiation of fracture site derived human mesenchymal stem cells
    A Gigante
    Clinica Ortopedica, Universita Politecnica delle Marche, Ancona, Italy
    J Biol Regul Homeost Agents 22:35-44. 2008
    ....
  44. ncbi Observations on possible effects of daily vitamin K replacement, especially upon warfarin therapy
    Murray Bern
    Cancer Center of Boston, New England Baptist Hospital, Harvard Medical School, Boston, Massachusetts, USA
    JPEN J Parenter Enteral Nutr 28:388-98. 2004
    ..This review offers a platform for further discussion and derived clinical research provoked by this new FDA recommendation...
  45. ncbi Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg)
    Katharina Nimptsch
    Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany
    Am J Clin Nutr 87:985-92. 2008
    ..Epidemiologic studies linking dietary intake of vitamin K with the development of prostate cancer have not yet been conducted...
  46. ncbi Vitamin K concentrations in the maternal milk of Japanese women
    T Kojima
    Nutritional Science Research Institute, Meiji Dairies Corporation, Odawara, Kanagawa, Japan
    Acta Paediatr 93:457-63. 2004
    ..To determine the concentration of vitamin K including K1 (phylloquinone) and K2 (menaquinone-n; MK-n) in the maternal milk of Japanese women...
  47. ncbi Viability and plasma vitamin K levels in the common bile duct-ligated rats
    Toshio Akimoto
    Division of Laboratory Animal Science, Nippon Medical School, Tokyo, Japan
    Exp Anim 54:155-61. 2005
    ..The enriched diet with vitamin K nutritional supplements seemed to contribute to the prolongation of the life span of CBDL rats...
  48. ncbi Post-translational modifications regulate matrix Gla protein function: importance for inhibition of vascular smooth muscle cell calcification
    L J Schurgers
    Cardiovascular Research Institute Maastricht and VitaK, University of Maastricht, Universiteitssingel 50, Maastricht, The Netherlands
    J Thromb Haemost 5:2503-11. 2007
    ..In vivo, MGP has been shown to be a potent inhibitor of vascular calcification; however, the precise molecular mechanism underlying the function of MGP is not yet fully understood...
  49. ncbi Effects of long-term vitamin K (phylloquinone) intake on retina aging
    Isabelle Carrié
    Department of Nutrition, Universite de Montreal, Montreal, Que, Canada H3C 3J7
    Nutr Neurosci 6:351-9. 2003
    ..These data suggest a role for vitamin K in maintaining the aging retina and suggest that the sparing effect of vitamin K does not reflect the survival-promoting (anti-apoptotic) activities of vitamin K-dependent proteins...
  50. ncbi Menaquinone-4 concentration is correlated with sphingolipid concentrations in rat brain
    Isabelle Carrié
    Departement de Nutrition, Universite de Montreal, H3C 3J7 Montreal, Canada
    J Nutr 134:167-72. 2004
    ..The strong associations reported here between brain MK-4 and sphingomyelin, sulfatides and gangliosides suggest that this vitamer may play an important role in the brain...
  51. ncbi Relationship between diet and anticoagulant response to warfarin: a factor analysis
    Silvia Maria Custódio das Dôres
    Depto de Nutrição e Dietética da Faculdade de Nutrição, Universidade Federal Fluminense UFF, Rua São Paulo, 30 4 andar Centro, Niteroi, RJ 24015 110, Brazil
    Eur J Nutr 46:147-54. 2007
    ..Diet composition is one of the factors that may contribute to intraindividual variability in the anticoagulant response to warfarin...
  52. ncbi Determination of vitamin K homologues by high-performance liquid chromatography with on-line photoreactor and peroxyoxalate chemiluminescence detection
    Sameh Ahmed
    Graduate School of Biomedical Sciences, Course of Pharmaceutical Sciences, Nagasaki University, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Anal Chim Acta 591:148-54. 2007
    ..The recoveries of PK, MK-4 and MK-7 were greater than 82% and the inter- and intra-assay R.S.D. values were 1.9-5.4%. The sensitivity and selectivity of this method were sufficient for clinical and nutritional applications...
  53. ncbi The conversion of vitamin K epoxide to vitamin K quinone and vitamin K quinone to vitamin K hydroquinone uses the same active site cysteines
    Da Yun Jin
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3280, USA
    Biochemistry 46:7279-83. 2007
    ..H., Huang, T.-Y., Williams, J., and Stafford, D. W. (2006) Proc. Natl. Acad. Sci. U S A. 103, 19308-19313]...
  54. ncbi [Protective effects of vitamin K against osteoporosis and its pleiotropic actions]
    Masao Kaneki
    Harvard Medical School, Massachusetts General Hospital, Department of Anesthesia and Critical Care
    Clin Calcium 16:1526-34. 2006
    ..Molecular bases of coagulation-unrelated pleiotropic actions of vitamin K and its implications in human health deserve further investigations...
  55. ncbi The secondary electron acceptor of photosystem I in Gloeobacter violaceus PCC 7421 is menaquinone-4 that is synthesized by a unique but unknown pathway
    Mamoru Mimuro
    Department of Technology and Ecology, Hall of Global Environmental Research, Kyoto University, Kyoto 606 8501, Japan
    FEBS Lett 579:3493-6. 2005
    ..violaceus genome. Since G. violaceus clearly synthesizes MQ-4, the combined results indicate that this cyanobacterium must have a novel pathway for the synthesis of 1,4-dihydroxy-2-naphthoic acid...
  56. ncbi Vitamins K1 and K2 potentiate hyperthermia by down-regulating Hsp72 expression in vitro and in vivo
    Shuji Shimohara
    Department of Molecular Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    Int J Oncol 27:1527-33. 2005
    ..The findings here that VK1 and VK2 inhibit heat-shock-induced Hsp72 suggest their possible use as an adjuvant for hyperthermia in cancer therapy...
  57. ncbi Vitamin k contents of meat, dairy, and fast food in the u.s. Diet
    Sonya J Elder
    Jean Mayer U S Department of Agriculture, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA
    J Agric Food Chem 54:463-7. 2006
    ..The presence of MK-4 in meat, eggs, and dairy foods could be important as physiologic functions unique to MK-4 are identified...
  58. ncbi Vitamin K status of healthy Japanese women: age-related vitamin K requirement for gamma-carboxylation of osteocalcin
    Naoko Tsugawa
    Department of Hygienic Sciences, Kobe Pharmaceutical University, Kobe, Japan
    Am J Clin Nutr 83:380-6. 2006
    ....
  59. ncbi Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis
    Kent J DeZee
    William Beaumont Army Medical Center, El Paso, Tex 79920 5001, USA
    Arch Intern Med 166:391-7. 2006
    ..0 are at increased risk for bleeding. We performed a meta-analysis to determine the effectiveness of phytonadione (vitamin K) in treating excessive anticoagulation...
  60. ncbi Dietary phylloquinone depletion and repletion in postmenopausal women: effects on bone and mineral metabolism
    L A Martini
    Mineral Bioavailability Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Osteoporos Int 17:929-35. 2006
    ..Despite a potential role of vitamin K in bone, little is known about the effects of altered dietary phylloquinone intake on the underlying components of bone and mineral metabolism...
  61. ncbi [Hemorrhagic complications during warfarin treatment]
    J Gumulec
    Onkologické centrum J G Mendla, Novy Jicin
    Vnitr Lek 52:79-91. 2006
    ..thrombosis.cz. The guidelines include a ready-reference chart whose objective is immediate and quick crash course in the clinical practice...
  62. ncbi Reversal of asymptomatic over-anticoagulation by orally administered vitamin K
    Peter Baker
    Department of Haematology, Oxford Radcliffe Hospitals NHS Trust, Oxford, UK
    Br J Haematol 133:331-6. 2006
    ..This regimen for non-urgent correction is therefore effective and returns patients to a safe INR level without over-reversing anticoagulation...
  63. ncbi [Determination of vitamin K in aojiru (green juice) products by HPLC]
    Narue Sakamaki
    Tama Branch Institute, Tokyo Metropolitan Institute of Public Health, Japan
    Shokuhin Eiseigaku Zasshi 47:85-8. 2006
    ..These results suggest that patients prescribed warfarin should take care about their intake of vitamin K from aojiru products...
  64. ncbi Menadione is a metabolite of oral vitamin K
    Henk H W Thijssen
    Department of Pharmacology, Cardiovascular Research Institute Maastricht, University of Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    Br J Nutr 95:260-6. 2006
    ..The observations make it likely that part of the menaquinone-4 in tissues results from uptake and prenylation of circulating menadione...
  65. ncbi Vitamin K status among children with cystic fibrosis and its relationship to bone mineral density and bone turnover
    Steven P Conway
    Pediatric Cystic Fibrosis Unit, St James University Hospital, Leeds, United Kingdom
    Pediatrics 115:1325-31. 2005
    ..The aim of this study was to assess vitamin K status in an unselected population of children with cystic fibrosis (CF) and to investigate any vitamin K effect on bone turnover and bone mineral status...
  66. ncbi Comparative uptake, metabolism, and utilization of menaquinone-4 and phylloquinone in human cultured cell lines
    Yoshitomo Suhara
    Department of Hygienic Sciences, Kobe Pharmaceutical University, 4 19 1 Motoyamakita machi, Kobe 658 8558, Japan
    Bioorg Med Chem 14:6601-7. 2006
    ..This methodology should be utilized to clarify some of the actions of vitamin K in target cells and facilitate the development of new vitamin K drugs...
  67. ncbi Antitumor effects of vitamins K1, K2 and K3 on hepatocellular carcinoma in vitro and in vivo
    Misuzu Hitomi
    Third Department of Internal Medicine, Kagawa University School of Medicine, Kagawa 761 0793, Japan
    Int J Oncol 26:713-20. 2005
    ..The results indicate that vitamins K2 and K3 may be useful agents for the treatment of patients with HCC...
  68. ncbi Method for the determination of vitamin K homologues in human plasma using high-performance liquid chromatography-tandem mass spectrometry
    Yoshitomo Suhara
    Department of Hygienic Sciences, Kobe Pharmaceutical University, 4 19 1, Motoyamakita machi, Higashinada ku, Kobe 658 8558, Japan
    Anal Chem 77:757-63. 2005
    ....
  69. ncbi [Vitamin K compounds]
    Akira Shirahata
    Department of Pediatrics, University of Occupational and Environmental Health, Japan
    Nihon Rinsho 62:178-80. 2004
  70. ncbi Expression of LRP1 by human osteoblasts: a mechanism for the delivery of lipoproteins and vitamin K1 to bone
    Andreas Niemeier
    Department of Orthopaedics, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Bone Miner Res 20:283-93. 2005
    ..Here we describe the expression of the multifunctional LRP1 by human osteoblasts in vitro and in vivo. We provide evidence that LRP1 plays an important role in the uptake of postprandial lipoproteins and vitamin K1 by human osteoblasts...
  71. ncbi Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats
    H M H Spronk
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands
    J Vasc Res 40:531-7. 2003
    ....
  72. ncbi Safety and effectiveness of low dose oral vitamin K1 administration in asymptomatic out-patients on warfarin or acenocoumarol with excessive anticoagulation
    Daniela Poli
    Haematologica 88:237-8. 2003
  73. ncbi Circulating levels of vitamin K1, menaquinone-4, and menaquinone-7 in healthy elderly Japanese women and patients with vertebral fractures and patients with hip fractures
    K Kawana
    Department of Orthopaedic Surgery, Hamamatsu University School of Medicine, Handa, Japan
    Endocr Res 27:337-43. 2001
    ..Undetectable levels of measured vitamin K1, MK-4 and MK-7 in most of subjects may significantly affect the results...
  74. ncbi Homozygosity mapping of a second gene locus for hereditary combined deficiency of vitamin K-dependent clotting factors to the centromeric region of chromosome 16
    Andreas Fregin
    Institut für Humangenetik Universität Würzburg Biozentrum, Wurzburg, Germany
    Blood 100:3229-32. 2002
    ..Assuming that FMFD and warfarin resistance are allelic, conserved synteny between human and mouse linkage groups would restrict the candidate gene interval to the centromeric region of the short arm of chromosome 16...
  75. ncbi Difference in the metabolism of vitamin K between liver and bone in vitamin K-deficient rats
    Toshiro Sato
    Chemicals Research Laboratories, Honen Corporation, Iwata gun, Shizuoka, Japan
    Br J Nutr 87:307-14. 2002
    ..Furthermore, the counteracting effect of MK-7 on prolonged PT in vitamin K-deficient rats was found to be higher than phylloquinone or MK-4...
  76. ncbi Menaquinone-4 in breast milk is derived from dietary phylloquinone
    H H W Thijssen
    Department of Pharmacology, University of Maastricht, The Netherlands
    Br J Nutr 87:219-26. 2002
    ..Phylloquinone supplementation to lactating mothers may be of benefit to the newborn infant, since both phylloquinone and menaquinone-4 are raised by supplementation...
  77. ncbi Shift of serum osteocalcin components between cord blood and blood at day 5 of life
    Nobuhiko Shimizu
    Department of Developmental Medicine Pediatrics, Osaka University Graduate School of Medicine, Osaka, Japan
    Pediatr Res 52:656-9. 2002
    ..The IRMA assay fails to distinguish Gla-OC from Glu-OC and caution is needed to estimate bone turnover with this method in the perinatal period...
  78. ncbi Content of phylloquinone and menaquinone in the tissues of mummichog Fundulus heteroclitus fed diets containing different forms of vitamin K
    M Udagawa
    National Research Institute of Fisheries Science, Kanazawa, Yokohama, Japan
    J Nutr Sci Vitaminol (Tokyo) 47:91-5. 2001
    ..This may be a factor in the high mortality in male mummichog during the spawning season but further clarification of the causes of the mortality is required...
  79. ncbi Clinical predictors of prolonged delay in return of the international normalized ratio to within the therapeutic range after excessive anticoagulation with warfarin
    E M Hylek
    General Medicine Division, Clinical Epidemiology Unit, Massachusetts General Hospital, 50 Staniford Street, 9th Floor, Boston, MA 02114, USA
    Ann Intern Med 135:393-400. 2001
    ..Decompensated congestive heart failure and active cancer greatly increase this risk...
  80. ncbi Simultaneous determination of vitamin K analogs in human serum by sensitive and selective high-performance liquid chromatography with electrochemical detection
    Hiroyuki Wakabayashi
    Department of Clinical Pharmacotherapy, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Nutrition 19:661-5. 2003
    ..We also applied this trace analysis method to the simultaneous determination of VKs in human serum to investigate the physiologic and pathophysiologic roles of VKs in the bone metabolism...
  81. ncbi Species comparison of vitamin K1 2,3-epoxide reductase activity in vitro: kinetics and warfarin inhibition
    Christina R Wilson
    Animal Disease Diagnostic Laboratory, Purdue University, 1175 ADDL, 460 South University, West Lafayette, IN 47907 2065, USA
    Toxicology 189:191-8. 2003
    ..Significant differences between the IC(50) values of murine and rat microsomes suggest differences in the susceptibility of these species to warfarin...
  82. ncbi Role of vitamin K and vitamin K-dependent proteins in vascular calcification
    L J Schurgers
    Department of Biochemistry, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands
    Z Kardiol 90:57-63. 2001
    ..The hypothesis is put forward that undercarboxylation of MGP is a risk factor for vascular calcification and that the present RDA values are too low to ensure full carboxylation of MGP...
  83. ncbi Weekly oral vitamin K prophylaxis in Denmark
    K N Hansen
    Department of Paediatrics, Viborg Kjellerup Hospital, Denmark
    Acta Paediatr 92:802-5. 2003
    ..To evaluate oral vitamin K prophylaxis at birth by giving 2 mg phytomenadione, followed by weekly oral vitamin K prophylaxis; 1 mg was administered by the parents until 3 mo of age...
  84. ncbi Menatetrenone (vitamin K2) acts directly on circulating human osteoclast precursors
    H Taira
    Department of Orthopaedic Surgery, Oita Medical University, Oita Gun, Japan
    Calcif Tissue Int 73:78-85. 2003
    ..These findings also suggest that geranylgeraniol, the side chain of menatetrenone, plays an important role in this inhibitory effect...
  85. ncbi A retrospective evaluation of vitamin K1 therapy to reverse the anticoagulant effect of warfarin
    Jingyang Fan
    Department of Pharmacy Services, College of Pharmacy, University of Kentucky Chandler Medical Center, Lexington 40536 0293, USA
    Pharmacotherapy 23:1245-50. 2003
    ..To assess compliance with the 2001 consensus guidelines of the American College of Chest Physicians (ACCP) regarding administration of vitamin K1 to reverse the anticoagulant effect of warfarin...
  86. ncbi Direct interaction between yeast NADH-ubiquinone oxidoreductase, succinate-ubiquinone oxidoreductase, and ubiquinol-cytochrome c oxidoreductase in the reduction of exogenous quinones
    Q S Zhu
    Department of Biochemistry, West Virginia University, School of Medicine, Morgantown 26506
    J Biol Chem 263:193-9. 1988
    ..The NADH dehydrogenase involved in the myxothiazol-sensitive quinone reduction faces the matrix side of the inner membrane suggesting that center o may be localized within the membrane at a similar depth as center i...
  87. ncbi Nutritional interventions related to bone turnover in European space missions and simulation models
    Martina Heer
    Institute of Aerospace Medicine, German Aerospace Center, DLR, Cologne, Germany
    Nutrition 18:853-6. 2002
    ..During and after supplementation, bone formation markers increased significantly during this part of the mission. Therefore, vitamin K seems to play a significant role in bone turnover during space flight...
  88. ncbi Vitamin K status of premature infants: implications for current recommendations
    D Kumar
    Department of Pediatrics, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio 44109, USA
    Pediatrics 108:1117-22. 2001
    ..The objective of this study was to assess vitamin K status in premature infants by measuring plasma vitamin K and plasma protein-induced in vitamin K absence (PIVKA II) from birth until 40 weeks' postconceptional age...
  89. doi The proteome map of spinach leaf peroxisomes indicates partial compartmentalization of phylloquinone (vitamin K1) biosynthesis in plant peroxisomes
    Lavanya Babujee
    Georg August University of Goettingen, Albrecht von Haller Institute for Plant Sciences, Department of Plant Biochemistry, Justus von Liebig Weg 11, D 37077 Goettingen, Germany
    J Exp Bot 61:1441-53. 2010
    ..This proteomic study, extended by in vivo subcellular localization analyses, indicates a novel function for plant peroxisomes in phylloquinone biosynthesis...
  90. ncbi Pregnancy in women who have epilepsy
    Page B Pennell
    Emory Epilepsy Program, Department of Neurology, Emory University School of Medicine, 101 Woodruff Circle, Suite 6000 Atlanta, GA 30322, USA
    Neurol Clin 22:799-820. 2004
    ....
  91. ncbi Effect of quinones on formation and properties of bacteriochlorophyll c aggregates
    Jan Alster
    Department of Chemical Physics and Optics, Faculty of Mathematics and Physics, Charles University, Prague, Czech Republic
    Photosynth Res 95:183-9. 2008
    ..Thus, the weak quenching seems to be a property of BChl c itself...
  92. ncbi [Hemostasis disturbance caused by cephalosporins with an N-methylthiotetrazole side chain. A randomized pilot study]
    H Schafer
    Institut für Medizinische Biometrie und Informatik, Universitat Heidelberg
    Arzneimittelforschung 39:1156-62. 1989
    ..Unexpectedly, the patients displaying an appearance of vitamin K1 2,3-epoxide showed a statistically significant increase of endogenous plasma vitamin K levels. This effect needs further investigation...
  93. ncbi Commercial variants of the prothrombin time test as a screening test of acquired coagulation factor II, VII, and X deficiencies in dogs
    R Mischke
    Clinic for Small Animals, School of Veterinary Medicine, Bischofsholer Damm 15, D 30173 Hannover, Germany
    Res Vet Sci 73:165-70. 2002
    ..001). The results show that, in contrast to the PT(ST), all three tested commercial prothrombin time variants are suitable for the detection of deficiencies of coagulation factors II, VII, and X in canine plasma...
  94. ncbi Vitamins D and K as pleiotropic nutrients: clinical importance to the skeletal and cardiovascular systems and preliminary evidence for synergy
    Parris M Kidd
    University of California, Berkeley, USA
    Altern Med Rev 15:199-222. 2010
    ..This review updates vitamin D and K skeletal and cardiovascular benefits and evidence for their synergy of action...
  95. ncbi Antimicrobial susceptibility of bifidobacteria
    C Moubareck
    Laboratoire de Microbiologie, UFR des Sciences Pharmaceutiques et Biologiques, Universite Rene Descartes, 75270 Paris, France
    J Antimicrob Chemother 55:38-44. 2005
    ..The aim of our study was to analyse the antibiotic susceptibility of various strains of Bifidobacterium spp. to a wide range of antimicrobial agents...
  96. ncbi Oral vitamin K versus placebo to correct excessive anticoagulation in patients receiving warfarin: a randomized trial
    Mark A Crowther
    McMaster University, Hamilton, Ontario, Canada
    Ann Intern Med 150:293-300. 2009
    ..Low-dose oral vitamin K decreases the international normalized ratio (INR) in overanticoagulated patients who receive warfarin therapy. Its effects on bleeding events are uncertain...
  97. ncbi Vitamin K requirement in Danish anticoagulant-resistant Norway rats (Rattus norvegicus)
    Mette D K Markussen
    Danish Pest Infestation Laboratory, Skovbrynet 14, DK 2800 Kongens Lyngby, Denmark
    Pest Manag Sci 59:913-20. 2003
    ..We found no indication of different resistance types being present in our test material since vitamin K requirement was not different between rats from separate sampling localities...
  98. ncbi Assessment of vitamin K deficiency in CF--how much sophistication is useful?
    Katharina Mosler
    Department of Paediatrics, Heinrich Heine University, Moorenstr 5, 40225 Dusseldorf, Germany
    J Cyst Fibros 2:91-6. 2003
    ..Routine supplementation of vitamin K(1) in PICF is presently subject of discussion...
  99. doi Is vitamin K consumption associated with cardio-metabolic disorders? A systematic review
    Karen Rees
    Health Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    Maturitas 67:121-8. 2010
    ..None of the studies used biomarkers. Currently there is no evidence for an effect of vitamin K1, but results for vitamin K2 look promising. Further prospective studies are required to confirm these findings...
  100. ncbi Vitamin K prophylaxis for preterm infants: a randomized, controlled trial of 3 regimens
    Paul Clarke
    Neonatal Unit, Hope Hospital, Salford, United Kingdom
    Pediatrics 118:e1657-66. 2006
    ..Preterm infants may be at particular risk from either inadequate or excessive vitamin K prophylaxis. Our goal was to assess vitamin K status and metabolism in preterm infants after 3 regimens of prophylaxis...
  101. doi Quinone oxidoreductases and vitamin K metabolism
    Xing Gong
    Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Vitam Horm 78:85-101. 2008
    ..Future studies are also required to identify the enzymes that catalyze high affinity reduction of vitamin K1 and K2 to hydroquinone for use in gamma-carboxylation reactions...

Research Grants82

  1. Effect of Vitamin K on Age-Related Bone Loss
    Sarah Booth; Fiscal Year: 2005
    ..The proposed trial provides a unique opportunity to determine if supplemental vitamin K will reduce age-related bone loss in elderly men and women, above that achieved by supplemental calcium and vitamin D alone. ..
  2. Human Cytochrome P450 4F Enzymes and Drug Interactions
    ZHUO MICHAEL WANG; Fiscal Year: 2010
    ..This proposal seeks to demonstrate a novel molecular mechanism for the statin-warfarin interaction and provide a pathway to develop an interaction-free statin-warfarin combination. ..
  3. VITAMIN K-DEPENDENT PROTEINS IN LIVER & ISOLATED CELLS
    Reidar Wallin; Fiscal Year: 1990
    ....
  4. VITAMIN K-DEPENDENT PROTEINS IN LIVER & ISOLATED CELLS
    Reidar Wallin; Fiscal Year: 1992
    ....
  5. REGULATION OF MACROPHAGE DEPENDENT ANGIOGENIC ACTIVITY
    SAMUEL LEIBOVICH; Fiscal Year: 2002
    ..abstract_text> ..
  6. REGULATION OF MACROPHAGE DEPENDENT ANGIOGENIC ACTIVITY
    SAMUEL LEIBOVICH; Fiscal Year: 2001
    ..abstract_text> ..
  7. REGULATION OF MACROPHAGE DEPENDENT ANGIOGENIC ACTIVITY
    SAMUEL LEIBOVICH; Fiscal Year: 1999
    ..abstract_text> ..
  8. REGULATION OF MACROPHAGE DEPENDENT ANGIOGENIC ACTIVITY
    SAMUEL LEIBOVICH; Fiscal Year: 2000
    ..abstract_text> ..
  9. ANTICOAGULANT THERAPY IN OLDER PATIENTS
    Seth Landefeld; Fiscal Year: 1991
    ..The findings will provide valuable insights into--and a prototype for--the prevention of drug-induced illness in older persons...
  10. PERINATAL DEVELOPMENT OF VITAMIN K-DEPENDENT HEMOSTASIS
    Edwin Bovill; Fiscal Year: 1992
    ..The results obtained from this investigation will be important in laying the foundation for improved therapeutic strategies in the future...
  11. PERINATAL DEVELOPMENT OF VITAMIN K-DEPENDENT HEMOSTASIS
    Edwin Bovill; Fiscal Year: 1993
    ..The results obtained from this investigation will be important in laying the foundation for improved therapeutic strategies in the future. ..
  12. Establishing the Precursors of Osteoporosis in Children
    Xiping Xu; Fiscal Year: 2010
    ....
  13. Establishing the Precursors of Osteoporosis in Children
    Xiping Xu; Fiscal Year: 2007
    ....
  14. Establishing the Precursors of Osteoporosis in Children
    Xiping Xu; Fiscal Year: 2009
    ....
  15. Effect of Vitamin K on Age-Related Bone Loss
    Sarah Booth; Fiscal Year: 2002
    ..The proposed trial provides a unique opportunity to determine if supplemental vitamin K will reduce age-related bone loss in elderly men and women, above that achieved by supplemental calcium and vitamin D alone. ..
  16. Vitamin K: vascular calcification and age-related bone *
    Sarah Booth; Fiscal Year: 2001
    ..The proposed ancillary trial provides a unique opportunity to determine if vitamin K supplementation will reduce progression of vascular calcification in older men and women...
  17. Dietary & non-dietary components of vitamin K metabolism
    Sarah Booth; Fiscal Year: 2008
    ..The findings of the proposed study are critical for the interpretation of the epidemiologic and clinical data used to determine optimal intakes at which vitamin K may have a protective role in bone health. ..
  18. Dietary & non-dietary components of vitamin K metabolism
    Sarah Booth; Fiscal Year: 2007
    ..The findings of the proposed study are critical for the interpretation of the epidemiologic and clinical data used to determine optimal intakes at which vitamin K may have a protective role in bone health. ..
  19. Dietary & non-dietary components of vitamin K metabolism
    Sarah Booth; Fiscal Year: 2006
    ..The findings of the proposed study are critical for the interpretation of the epidemiologic and clinical data used to determine optimal intakes at which vitamin K may have a protective role in bone health. ..
  20. Dietary & non-dietary components of vitamin K metabolism
    Sarah Booth; Fiscal Year: 2005
    ..The findings of the proposed study are critical for the interpretation of the epidemiologic and clinical data used to determine optimal intakes at which vitamin K may have a protective role in bone health. ..
  21. Vitamin K: vascular calcification and age-related bone *
    Sarah Booth; Fiscal Year: 2004
    ..The proposed ancillary trial provides a unique opportunity to determine if vitamin K supplementation will reduce progression of vascular calcification in older men and women...
  22. Effect of Vitamin K on Age-Related Bone Loss
    Sarah Booth; Fiscal Year: 2004
    ..The proposed trial provides a unique opportunity to determine if supplemental vitamin K will reduce age-related bone loss in elderly men and women, above that achieved by supplemental calcium and vitamin D alone. ..
  23. Vitamin K: vascular calcification and age-related bone *
    Sarah Booth; Fiscal Year: 2003
    ..The proposed ancillary trial provides a unique opportunity to determine if vitamin K supplementation will reduce progression of vascular calcification in older men and women...
  24. Effect of Vitamin K on Age-Related Bone Loss
    Sarah Booth; Fiscal Year: 2003
    ..The proposed trial provides a unique opportunity to determine if supplemental vitamin K will reduce age-related bone loss in elderly men and women, above that achieved by supplemental calcium and vitamin D alone. ..
  25. Vitamin K: vascular calcification and age-related bone *
    Sarah Booth; Fiscal Year: 2002
    ..The proposed ancillary trial provides a unique opportunity to determine if vitamin K supplementation will reduce progression of vascular calcification in older men and women...
  26. VITAMIN K INSUFFICIENCY--A RISK FACTOR FOR OSTEOPOROSIS
    Sarah Booth; Fiscal Year: 2001
    ..Results of the studies proposed could lead to effective intervention programs that reduce bone loss resulting in a decreased risk and incidence of osteoporosis. ..
  27. RECEPTORS FOR COCAINE AND DOPAMINE
    Philip Seeman; Fiscal Year: 1992
    ..The availability of clones for these receptors would facilitate new drug design and provide new markers for disease linkage studies in families...
  28. RECEPTORS FOR COCAINE AND DOPAMINE
    Philip Seeman; Fiscal Year: 1991
    ..The availability of clones for these receptors would facilitate new drug design and provide new markers for disease linkage studies in families...
  29. RECEPTORS MEDIATING DRUG DEPENDENCE
    Philip Seeman; Fiscal Year: 1999
    ....
  30. RECEPTORS FOR COCAINE AND DOPAMINE
    Philip Seeman; Fiscal Year: 1993
    ..The availability of clones for these receptors would facilitate new drug design and provide new markers for disease linkage studies in families...
  31. VITAMIN K INSUFFICIENCY--A RISK FACTOR FOR OSTEOPOROSIS
    Sarah Booth; Fiscal Year: 1999
    ..Results of the studies proposed could lead to effective intervention programs that reduce bone loss resulting in a decreased risk and incidence of osteoporosis. ..
  32. Effect of Vitamin K on Age-Related Bone Loss
    Sarah Booth; Fiscal Year: 2001
    ..The proposed trial provides a unique opportunity to determine if supplemental vitamin K will reduce age-related bone loss in elderly men and women, above that achieved by supplemental calcium and vitamin D alone. ..
  33. VITAMIN K INSUFFICIENCY--A RISK FACTOR FOR OSTEOPOROSIS
    Sarah Booth; Fiscal Year: 2000
    ..Results of the studies proposed could lead to effective intervention programs that reduce bone loss resulting in a decreased risk and incidence of osteoporosis. ..
  34. Efficacy of Optimal Levels of Dietary Dairy on Modulation of Adolescent Weight
    Joan Lappe; Fiscal Year: 2010
    ..Such a dairy intervention would be congruent with currently recommended calcium and dairy intake. ..
  35. EXERCISE AND CALCIUM EFFECT ON PUBERTAL BONE GAIN
    Joan Lappe; Fiscal Year: 2006
    ..If these findings hold, they would provide strong support for the essential role of calcium in addition to exercise in maximizing bone mass in growing females. ..
  36. REGULATIOIN OF RENAL PHOSPHATE EXCRETION AND VITAMIN D METABOLISM BY FGF 7
    Rajiv Kumar; Fiscal Year: 2008
    ..The interaction between the FGF 7 and other PTNs will be clarified. Such information will significantly enhance our knowledge of mineralization processes and Pi homeostasis. ..
  37. Evaluating e-Prescribing in a Community-based, Integrated Health System
    EMILY DEVINE; Fiscal Year: 2008
    ..As an independent investigator, Dr. Devine will contribute to the advancement of this field. ..
  38. EXPRESSION AND STRUCTURE OF THE CALCIUM SENSING RECEPTOR
    Rajiv Kumar; Fiscal Year: 2007
    ..Furthermore, this information will serve as the basis for more extensive experiments involving the structure of the full-length receptor. [unreadable] [unreadable]..
  39. Vitamin K, Bone, and Arterial Calcification
    Reidar Wallin; Fiscal Year: 2005
    ..The proposed work will provide basic knowledge of BMP-2 growth factor mediated calcification as it is linked to the function of a fat-soluble vitamin (vitamin K) and biosynthesis of vitamin K-dependent proteins. ..
  40. BONE DENSITY AND FOREARM FRACTURES IN INJURED CHILDREN
    Heidi Kalkwarf; Fiscal Year: 2000
    ..Understanding the determinants of this measurement will inform strategies to promote healthy bone and decrease fracture risk in childhood. ..
  41. Hyperoxaluria and Nephrolithiasis After Gastric Bypass Surgery for Obesity
    Rajiv Kumar; Fiscal Year: 2008
    ..Finally, we will study why these complications occur and we will develop ways in which to prevent kidney stones and loss of kidney function after gastric bypass surgery. [unreadable] [unreadable] [unreadable]..
  42. VITAMIN K AND BONE TURNOVER IN POSTMENOPAUSAL WOMEN
    Neil Binkley; Fiscal Year: 2003
    ..abstract_text> ..
  43. THE PHYSIOLOGY AND METABOLISM OF VITAMIN D
    Rajiv Kumar; Fiscal Year: 1991
    ....
  44. Vitamin K, Bone, and Arterial Calcification
    Reidar Wallin; Fiscal Year: 2004
    ..The proposed work will provide basic knowledge of BMP-2 growth factor mediated calcification as it is linked to the function of a fat-soluble vitamin (vitamin K) and biosynthesis of vitamin K-dependent proteins. ..
  45. THE PHYSIOLOGY AND METABOLISM OF VITAMIN D
    Rajiv Kumar; Fiscal Year: 1993
    ....
  46. Inducible Nitric Oxide Synthase and Insulin Resistance
    Masao Kaneki; Fiscal Year: 2008
    ..This project will provide new information to establish novel strategies to prevent and/or treat insulin resistance and obesity-related diabetes. ..
  47. THE PHYSIOLOGY AND METABOLISM OF VITAMIN D
    Rajiv Kumar; Fiscal Year: 1990
    ..An examination of the gene for CaBP would be of importance in understanding how it is organized with respect to certain putative regulatory sequences...
  48. REGULATIOIN OF RENAL PHOSPHATE EXCRETION AND VITAMIN D METABOLISM BY FGF 7
    Rajiv Kumar; Fiscal Year: 2010
    ..The interaction between the FGF 7 and other PTNs will be clarified. Such information will significantly enhance our knowledge of mineralization processes and Pi homeostasis. ..
  49. BONE DENSITY AND FOREARM FRACTURES IN INJURED CHILDREN
    Heidi Kalkwarf; Fiscal Year: 2001
    ..Understanding the determinants of this measurement will inform strategies to promote healthy bone and decrease fracture risk in childhood. ..
  50. Predictors and Consequences of Subchondral Bone Attrition in Osteoarthritis
    Tuhina Neogi; Fiscal Year: 2008
    ....
  51. Inducible Nitric Oxide Synthase and Insulin Resistance
    Masao Kaneki; Fiscal Year: 2009
    ..This project will provide new information to establish novel strategies to prevent and/or treat insulin resistance and obesity-related diabetes. ..
  52. VITAMIN K AND BONE TURNOVER IN POSTMENOPAUSAL WOMEN
    Neil Binkley; Fiscal Year: 2002
    ..abstract_text> ..
  53. VITAMIN K AND BONE TURNOVER IN POSTMENOPAUSAL WOMEN
    Neil Binkley; Fiscal Year: 2001
    ..abstract_text> ..
  54. Predictors and Consequences of Subchondral Bone Attrition in Osteoarthritis
    Tuhina Neogi; Fiscal Year: 2007
    ....
  55. BONE DENSITY AND FOREARM FRACTURES IN INJURED CHILDREN
    Heidi Kalkwarf; Fiscal Year: 2002
    ..Understanding the determinants of this measurement will inform strategies to promote healthy bone and decrease fracture risk in childhood. ..
  56. Inducible Nitric Oxide Synthase and Insulin Resistance
    Masao Kaneki; Fiscal Year: 2003
    ..abstract_text> ..
  57. VITAMIN K AND BONE TURNOVER IN POSTMENOPAUSAL WOMEN
    Neil Binkley; Fiscal Year: 2000
    ..abstract_text> ..
  58. Inducible Nitric Oxide Synthase and Insulin Resistance
    Masao Kaneki; Fiscal Year: 2004
    ..abstract_text> ..
  59. Changing Cafeteria Portion Sizes to Prevent Weight Gain
    Stella Volpe; Fiscal Year: 2003
    ..Thus, our next step would be to work with larger communities to focus on altering portion sizes in cafeterias, and even restaurants that do not offer "all you can eat" options. ..
  60. Inducible Nitric Oxide Synthase and Insulin Resistance
    Masao Kaneki; Fiscal Year: 2002
    ..abstract_text> ..
  61. Inducible Nitric Oxide Synthase and Insulin Resistance
    Masao Kaneki; Fiscal Year: 2006
    ..This project will provide new information to establish novel strategies to prevent and/or treat insulin resistance and obesity-related diabetes. ..
  62. Inducible Nitric Oxide Synthase and Insulin Resistance
    Masao Kaneki; Fiscal Year: 2007
    ..This project will provide new information to establish novel strategies to prevent and/or treat insulin resistance and obesity-related diabetes. ..
  63. The Magnesium and Metabolic Syndrome Trial
    Stella Volpe; Fiscal Year: 2008
    ..If effective in improving insulin resistance in the metabolic syndrome, magnesium supplementation could have a great public health impact by delaying or preventing type 2 diabetes mellitus, and also in decreasing health care costs. ..