propofol

Summary

Summary: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206)

Top Publications

  1. ncbi Remifentanil target-controlled infusion vs propofol target-controlled infusion for conscious sedation for awake fibreoptic intubation: a double-blinded randomized controlled trial
    M R Rai
    Nuffield Department of Anaesthetics, Oxford Radcliffe NHS Trust, Headley Way, Headington, Oxford OX3 9DU, UK
    Br J Anaesth 100:125-30. 2008
  2. ncbi Bispectral analysis measures sedation and memory effects of propofol, midazolam, isoflurane, and alfentanil in healthy volunteers
    P S Glass
    Department of Anesthesiology, Duke University, Durham, North Carolina 27710, USA
    Anesthesiology 86:836-47. 1997
  3. pmc The general anesthetic propofol excites nociceptors by activating TRPV1 and TRPA1 rather than GABAA receptors
    Michael J M Fischer
    Institute of Physiology and Pathophysiology, University of Erlangen Nuremberg, Erlangen 91054, Germany
    J Biol Chem 285:34781-92. 2010
  4. ncbi Tracheal intubating conditions using propofol and remifentanil target-controlled infusions
    A M Troy
    University Department of Anaesthesia, Glasgow Royal Infirmary, Glasgow UK
    Anaesthesia 57:1204-7. 2002
  5. ncbi Effect of ondansetron pretreatment on pain after rocuronium and propofol injection: a randomised, double-blind controlled comparison with lidocaine
    M S Reddy
    Department of Anaesthesia, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074
    Anaesthesia 56:902-5. 2001
  6. ncbi The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers
    T W Schnider
    Institut für Anästhesie und Intensivmedizin, Inselspital, Universitat Bern, Switzerland
    Anesthesiology 88:1170-82. 1998
  7. doi Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials
    Stephan M Jakob
    Department of Intensive Care Medicine, Bern University Hospital and University of Bern, Bern, Switzerland
    JAMA 307:1151-60. 2012
  8. ncbi Inhaled anesthetic enhancement of amyloid-beta oligomerization and cytotoxicity
    Roderic G Eckenhoff
    Department of Anesthesia, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4283, USA
    Anesthesiology 101:703-9. 2004
  9. pmc Changes in resting neural connectivity during propofol sedation
    Emmanuel A Stamatakis
    Division of Anaesthesia, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 5:e14224. 2010
  10. doi Breakdown of within- and between-network resting state functional magnetic resonance imaging connectivity during propofol-induced loss of consciousness
    Pierre Boveroux
    Department of Anesthesia and Intensive Care Medicine, University of Liege, Liege, Belgium
    Anesthesiology 113:1038-53. 2010

Research Grants

Detail Information

Publications310 found, 100 shown here

  1. ncbi Remifentanil target-controlled infusion vs propofol target-controlled infusion for conscious sedation for awake fibreoptic intubation: a double-blinded randomized controlled trial
    M R Rai
    Nuffield Department of Anaesthetics, Oxford Radcliffe NHS Trust, Headley Way, Headington, Oxford OX3 9DU, UK
    Br J Anaesth 100:125-30. 2008
    ..This study compares the suitability of remifentanil target-controlled infusion (TCI) to propofol TCI for conscious sedation during AFOI in patients with bona fide difficult airways.
  2. ncbi Bispectral analysis measures sedation and memory effects of propofol, midazolam, isoflurane, and alfentanil in healthy volunteers
    P S Glass
    Department of Anesthesiology, Duke University, Durham, North Carolina 27710, USA
    Anesthesiology 86:836-47. 1997
    ..This study was designed to evaluate this relation for four commonly used anesthetic drugs: propofol, midazolam, isoflurane, and alfentanil.
  3. pmc The general anesthetic propofol excites nociceptors by activating TRPV1 and TRPA1 rather than GABAA receptors
    Michael J M Fischer
    Institute of Physiology and Pathophysiology, University of Erlangen Nuremberg, Erlangen 91054, Germany
    J Biol Chem 285:34781-92. 2010
    ..we identify distinct molecular mechanisms that mediate an activation of sensory neurons by 2,6-diisopropylphenol (propofol), a commonly used intravenous anesthetic known to elicit intense pain upon injection...
  4. ncbi Tracheal intubating conditions using propofol and remifentanil target-controlled infusions
    A M Troy
    University Department of Anaesthesia, Glasgow Royal Infirmary, Glasgow UK
    Anaesthesia 57:1204-7. 2002
    ..the most appropriate dose of remifentanil required for intubation, using a steady effect-site concentration of propofol and without the use of neuromuscular blocking drugs...
  5. ncbi Effect of ondansetron pretreatment on pain after rocuronium and propofol injection: a randomised, double-blind controlled comparison with lidocaine
    M S Reddy
    Department of Anaesthesia, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074
    Anaesthesia 56:902-5. 2001
    ..study the effect of ondansetron pretreatment on the pain produced after intravenous injection of rocuronium and propofol in comparison with lidocaine, 60 patients were randomly assigned to one of three groups...
  6. ncbi The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers
    T W Schnider
    Institut für Anästhesie und Intensivmedizin, Inselspital, Universitat Bern, Switzerland
    Anesthesiology 88:1170-82. 1998
    Unresolved issues with propofol include whether the pharmacokinetics are linear with dose, are influenced by method of administration (bolus vs. infusion), or are influenced by age...
  7. doi Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials
    Stephan M Jakob
    Department of Intensive Care Medicine, Bern University Hospital and University of Bern, Bern, Switzerland
    JAMA 307:1151-60. 2012
    Long-term sedation with midazolam or propofol in intensive care units (ICUs) has serious adverse effects...
  8. ncbi Inhaled anesthetic enhancement of amyloid-beta oligomerization and cytotoxicity
    Roderic G Eckenhoff
    Department of Anesthesia, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4283, USA
    Anesthesiology 101:703-9. 2004
    ..The authors hypothesize that inhaled anesthetics contribute to these effects through a durable enhancement of peptide oligomerization...
  9. pmc Changes in resting neural connectivity during propofol sedation
    Emmanuel A Stamatakis
    Division of Anaesthesia, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 5:e14224. 2010
    ....
  10. doi Breakdown of within- and between-network resting state functional magnetic resonance imaging connectivity during propofol-induced loss of consciousness
    Pierre Boveroux
    Department of Anesthesia and Intensive Care Medicine, University of Liege, Liege, Belgium
    Anesthesiology 113:1038-53. 2010
    ..Resting-state functional magnetic resonance imaging allows investigating whole-brain connectivity changes during pharmacological modulation of the level of consciousness...
  11. pmc Propofol anesthesia and sleep: a high-density EEG study
    Michael Murphy
    Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
    Sleep 34:283-91A. 2011
    ..We used high-density electroencephalography (hd-EEG) and source modeling to investigate the cortical processes underlying propofol anesthesia and compare them to sleep.
  12. pmc Propofol directly increases tau phosphorylation
    Robert A Whittington
    Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America
    PLoS ONE 6:e16648. 2011
    ..However, the effects of propofol, a common clinically used intravenous anesthetic, on tau phosphorylation under normothermic conditions are ..
  13. pmc Thalamocortical model for a propofol-induced alpha-rhythm associated with loss of consciousness
    Shinung Ching
    Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 107:22665-70. 2010
    Recent data reveal that the general anesthetic propofol gives rise to a frontal α-rhythm at dose levels sufficient to induce loss of consciousness...
  14. pmc Anesthetic propofol attenuates the isoflurane-induced caspase-3 activation and Aβ oligomerization
    Yiying Zhang
    Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
    PLoS ONE 6:e27019. 2011
    ..In contrast, propofol, the most commonly used intravenous anesthetic, has been reported to have neuroprotective effects...
  15. ncbi Trained registered nurses/endoscopy teams can administer propofol safely for endoscopy
    Douglas K Rex
    Division of Gastroenterology Hepatology, Department of Medicine, Indiana University Hospital, Indianapolis, Indiana 46202, USA
    Gastroenterology 129:1384-91. 2005
    b>Propofol has advantages as a sedative for endoscopic procedures. Its administration by anesthesia specialists is associated with high cost...
  16. doi Incidence of sedation-related complications with propofol use during advanced endoscopic procedures
    Gregory A Cote
    Division of Gastroenterology and Hepatology, Washington University, St Louis, Missouri 63110, USA
    Clin Gastroenterol Hepatol 8:137-42. 2010
    b>Propofol is an effective sedative in advanced endoscopy. However, the incidence of sedation-related complications is unclear...
  17. pmc Connectivity changes underlying spectral EEG changes during propofol-induced loss of consciousness
    Melanie Boly
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liège and Sart Tilman Hospital, 4000 Liege, Belgium
    J Neurosci 32:7082-90. 2012
    ..Recent electrophysiological reports suggest that while initial propofol infusion provokes an increase in fast rhythms (from beta to gamma range), slow activity (from delta to alpha ..
  18. doi Brain functional integration decreases during propofol-induced loss of consciousness
    Jessica Schrouff
    Cyclotron Research Centre, University of Liege, Liege, Belgium
    Neuroimage 57:198-205. 2011
    ..In this paper, we tested the hypothesis that the loss of consciousness caused by propofol anesthesia is associated with a significant reduction in the capacity of the brain to integrate information...
  19. ncbi Effects of sevoflurane, propofol, and adjunct nitrous oxide on regional cerebral blood flow, oxygen consumption, and blood volume in humans
    Kaike K Kaisti
    Department of Anesthesiology, Turku University Hospital, Finland
    Anesthesiology 99:603-13. 2003
    ..The authors quantified the effects of sevoflurane and propofol as sole anesthetics and in combination with N2O on regional cerebral blood flow (rCBF), metabolic rate of oxygen (..
  20. doi Cognitive function after sevoflurane- vs propofol-based anaesthesia for on-pump cardiac surgery: a randomized controlled trial
    J Schoen
    Department of Anesthesiology, University of Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Br J Anaesth 106:840-50. 2011
    ..This study was designed to determine cognitive and clinical outcomes after sevoflurane- compared with propofol-based anaesthesia for on-pump cardiac surgery and the impact of decreases in under different anaesthesia regimens.
  21. pmc Molecular targets underlying general anaesthesia
    Nicholas P Franks
    Biophysics Section, The Blackett Laboratory, Imperial College London, London SW7 2AZ
    Br J Pharmacol 147:S72-81. 2006
    ..For certain intravenous anaesthetics, such as propofol and etomidate, the target has been identified as the GABA(A) receptor, with particular subunits playing a crucial ..
  22. ncbi Clinically relevant concentrations of propofol but not midazolam alter in vitro dendritic development of isolated gamma-aminobutyric acid-positive interneurons
    Laszlo Vutskits
    Department of Anesthesiology, Pharmacology and Surgical Intensive Care, University Hospital of Geneva, Switzerland
    Anesthesiology 102:970-6. 2005
    Recent laboratory studies showed that exposure to supraclinical concentrations of propofol can induce cell death of immature neurons...
  23. ncbi Use of target controlled infusion to derive age and gender covariates for propofol clearance
    Martin White
    Department of Anaesthesiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Clin Pharmacokinet 47:119-27. 2008
    Attempts to describe the variability of propofol pharmacokinetics in adults and to derive population covariates have been sparse and limited mainly to experiments based on bolus doses or infusions in healthy volunteers...
  24. pmc Stable and dynamic cortical electrophysiology of induction and emergence with propofol anesthesia
    Jonathan D Breshears
    Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:21170-5. 2010
    ..a unique comprehensive recording of invasive human cortical physiology during both induction and emergence from propofol anesthesia...
  25. ncbi Propofol infusion versus intermittent meperidine and midazolam injection for conscious sedation in ERCP
    Pradermchai Kongkam
    Division of Gastroenterology, Department of Internal Medicine, Chulalongkorn University, Bangkok, Thailand
    J Gastrointestin Liver Dis 17:291-7. 2008
    ERCP generally requires longer time than standard endoscopy. Only few studies have shown benefit of intermittent propofol over conventional sedation...
  26. ncbi Spectral entropy measurement of patient responsiveness during propofol and remifentanil. A comparison with the bispectral index
    A L G Vanluchene
    Department of Anaesthesia, Gent University Hospital, De Pintelaan 185, B 9000 Gent, Belgium
    Br J Anaesth 93:645-54. 2004
    ..entropy (RE), based on the irregularity of the EEG, to measure loss of response to verbal command (LOR(verbal)) and noxious stimulus (LOR(noxious)) with the bispectral index (BIS) during propofol infusion with and without remifentanil.
  27. ncbi Propofol and halothane versus sevoflurane in paediatric day-case surgery: induction and recovery characteristics
    J K Moore
    Wirral Hospital Trust, Cheshire CH49 5PE, UK
    Br J Anaesth 90:461-6. 2003
    The aim of this study was to compare the induction and recovery characteristics associated with propofol induction and halothane maintenance with sevoflurane anaesthesia in paediatric day surgery.
  28. doi Propofol induction reduces the capacity for neural information integration: implications for the mechanism of consciousness and general anesthesia
    UnCheol Lee
    Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI 48109 0048, USA
    Conscious Cogn 18:56-64. 2009
    ..EEG) recordings were obtained from 14 subjects undergoing induction of general anesthesia with propofol. We quantified changes in mean information integration capacity in each band of the EEG...
  29. doi Evaluation of the predictive performance of four pharmacokinetic models for propofol
    J B Glen
    Research Department, Glen Pharma Ltd, 35A Bexton Road, Knutsford, Cheshire, UK
    Br J Anaesth 102:626-32. 2009
    This study has compared the predictive performance of four pharmacokinetic models, two of which are currently incorporated in commercial target-controlled infusion pumps for the administration of propofol.
  30. ncbi Prevention of pain on injection of propofol: a comparison of remifentanil with alfentanil in children
    A Rahman Al-Refai
    Department of Anesthesia and Intensive Care, Al Sabah Hospital, Kuwait
    Minerva Anestesiol 73:219-23. 2007
    b>Propofol has a high incidence of pain on injection, particularly when a vein on the back of hand is used. Administration of lidocaine, either before or mixed with propofol remains the most widely used method to attenuate this pain...
  31. ncbi Possible anaphylaxis after propofol in a child with food allergy
    Kristi N Hofer
    Department of Pharmacy Services, University of Virginia Health System, Charlottesville, VA 22908, USA
    Ann Pharmacother 37:398-401. 2003
    To report a case of anaphylaxis due to propofol in a child with allergies to egg and peanut oil.
  32. ncbi The influence of age on propofol pharmacodynamics
    T W Schnider
    Institut für Anästhesie und Intensivbehandlung, Inselspital, Universitat Bern, Switzerland
    Anesthesiology 90:1502-16. 1999
    The authors studied the influence of age on the pharmacodynamics of propofol, including characterization of the relation between plasma concentration and the time course of drug effect.
  33. doi Sevoflurane vs. propofol in patients with coronary disease undergoing mitral surgery: a randomised study
    E Bignami
    Department of Anesthesia and Intensive Care, Universita Vita Salute San Raffaele, Milan, Italy
    Acta Anaesthesiol Scand 56:482-90. 2012
    ..We therefore performed a randomised controlled trial (sevoflurane vs. propofol) to compare cardiac troponin release in patients with coronary disease undergoing mitral surgery.
  34. pmc Granger causality analysis of steady-state electroencephalographic signals during propofol-induced anaesthesia
    Adam B Barrett
    Sackler Centre for Consciousness Science, Department of Informatics, University of Sussex, Brighton, United Kingdom
    PLoS ONE 7:e29072. 2012
    ..We apply the method to EEG data obtained from subjects undergoing propofol-induced anaesthesia, with signals source-localized to the anterior and posterior cingulate cortices...
  35. doi Long-term sedation in intensive care unit: a randomized comparison between inhaled sevoflurane and intravenous propofol or midazolam
    Malcie Mesnil
    Department of Anesthesiology and Critical Care Lapeyronie DAR A, Montpellier I University and Montpellier University Lapeyronie Hospital, Institut National de la Sante et de la Recherche Medicale INSERM, Equipe soutenue par la Région et l Inserm ERI 25, route de Ganges, 34295 Montpellier, Cedex 5, France
    Intensive Care Med 37:933-41. 2011
    To evaluate efficacy and adverse events related to inhaled sevoflurane for long-term sedation compared with standard intravenous (i.v.) sedation with propofol or midazolam.
  36. doi Adverse events during monitored anesthesia care for GI endoscopy: an 8-year experience
    Massimo Agostoni
    Department of Anesthesiology, Vita Salute University of Milan, IRCCS H San Raffaele, Milan, Italy
    Gastrointest Endosc 74:266-75. 2011
    ..The importance of sedation during endoscopy is well established. There is no consensus about the best techniques for sedation, which specialist should perform it, and in which location...
  37. doi The effect of prolonged anesthesia with isoflurane, propofol, dexmedetomidine, or ketamine on neural cell proliferation in the adult rat
    Avery Tung
    Department of Anesthesia and Critical Care, University of Chicago, Chicago, Illinois, USA
    Anesth Analg 106:1772-7. 2008
    ..To test this hypothesis, we investigated the effects of prolonged anesthesia with four different anesthetics on hippocampal cell proliferation in young and older rats...
  38. doi Propofol sedation during endoscopy in patients with cirrhosis, and utility of psychometric tests and critical flicker frequency in assessment of recovery from sedation
    P Sharma
    Institute of Liver and Biliary Sciences, Vasant Kunj, New Delhi, India
    Endoscopy 43:400-5. 2011
    ..Patients with cirrhosis who undergo endoscopy under sedation could be at increased risk of complications. We assessed the utility of the critical flicker frequency (CFF) in the recovery of cognitive function...
  39. ncbi The effect of lidocaine on the globule size distribution of propofol emulsions
    Jong Woo Park
    Department of Pharmaceutics, College of Pharmacy, Sungkyunkwan University, Suwon, South Korea
    Anesth Analg 97:769-71. 2003
    In this study, we sought to determine the globule size distribution of a propofol/lidocaine mixture as a function of lidocaine concentration and time elapsed after mixing in a standard formulation of propofol emulsion (Diprivan) and in a ..
  40. ncbi Reduction of pain during induction with target-controlled propofol and remifentanil
    J R Lee
    Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, 28, Yongon Dong, Jongno gu, Seoul 110 744, Korea
    Br J Anaesth 99:876-80. 2007
    Pain on injection of propofol is unpleasant...
  41. ncbi Comparison of recovery profile after ambulatory anesthesia with propofol, isoflurane, sevoflurane and desflurane: a systematic review
    Anil Gupta
    Department of Anesthesiology and Critical Care, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Anesth Analg 98:632-41, table of contents. 2004
    ..A second search strategy was used combining two of the words "propofol," "isoflurane," "sevoflurane," or "desflurane"...
  42. doi Cortical and subcortical connectivity changes during decreasing levels of consciousness in humans: a functional magnetic resonance imaging study using propofol
    Roisin Ni Mhuircheartaigh
    Centre for Functional Magnetic Resonance of the Brain FMRIB, Department of Clinical Neurology and Nuffield Department of Anaesthetics, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    J Neurosci 30:9095-102. 2010
    ..2000; Mashour, 2006). We investigated the effects of propofol, widely used for anesthesia and sedation, on spontaneous and evoked cerebral activity using functional magnetic ..
  43. ncbi Propofol impairment of mitochondrial respiration in isolated perfused guinea pig hearts determined by reflectance spectroscopy
    K A Schenkman
    Department of Pediatrics, University of Wisconsin, Madison, USA
    Crit Care Med 28:172-7. 2000
    To simultaneously determine the effect of propofol on myocardial oxygenation, mitochondrial function, and whole organ function in an isolated heart model, using optical reflectance spectroscopy.
  44. ncbi Comparative evaluation of the Datex-Ohmeda S/5 Entropy Module and the Bispectral Index monitor during propofol-remifentanil anesthesia
    Gunter N Schmidt
    Department of Anesthesiology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Anesthesiology 101:1283-90. 2004
    ..The aim of the current study was to compare the accuracy of SE and RE with the Bispectral Index(R) monitor (BIS(R); Aspect Medical Systems, Newton, MA) during propofol-remifentanil anesthesia.
  45. doi Effectiveness, safety, and pharmacokinetic and pharmacodynamic characteristics of microemulsion propofol in patients undergoing elective surgery under total intravenous anaesthesia
    J A Jung
    Department of Clinical Pharmacology and Therapeutics, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Pungnap 2 dong, Songpa Gu, Seoul 138 736, Korea
    Br J Anaesth 104:563-76. 2010
    The aims of this study were to investigate the effectiveness, safety, pharmacokinetics, and pharmacodynamics of microemulsion propofol, Aquafol (Daewon Pharmaceutical Co., Ltd, Seoul, Republic of Korea).
  46. ncbi Propofol: therapeutic indications and side-effects
    Paul E Marik
    Department of Critical Car Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Curr Pharm Des 10:3639-49. 2004
    b>Propofol (2, 6-diisopropylphenol) is a potent intravenous hypnotic agent which is widely used for the induction and maintenance of anesthesia and for sedation in the intensive care unit...
  47. ncbi Pharmacokinetics and pharmacodynamics of propofol microemulsion and lipid emulsion after an intravenous bolus and variable rate infusion
    Kye Min Kim
    Department of Anesthesiology and Pain Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea
    Anesthesiology 106:924-34. 2007
    The aim of this trial was to evaluate the induction and recovery characteristics of microemulsion propofol (Aquafol; Daewon Pharmaceutical Co., Ltd., Seoul, Korea). Pharmacokinetics, pharmacodynamics, and safety profile were investigated...
  48. ncbi The efficacy, side effects, and recovery characteristics of dexmedetomidine versus propofol when used for intraoperative sedation
    Shahbaz R Arain
    Department of Anesthesiology, Medical College of Wisconsin and VA Medical Center, Milwaukee, Wisconsin, USA
    Anesth Analg 95:461-6, table of contents. 2002
    We evaluated the cardio-respiratory effects of equi-sedative doses of dexmedetomidine and propofol for intraoperative sedation...
  49. ncbi Neonatal exposure to a combination of N-methyl-D-aspartate and gamma-aminobutyric acid type A receptor anesthetic agents potentiates apoptotic neurodegeneration and persistent behavioral deficits
    Anders Fredriksson
    Department of Neuroscience, Psychiatry Ulleraker, Uppsala University, Uppsala, Sweden
    Anesthesiology 107:427-36. 2007
    ..This study examined whether different anesthetic agents, alone and in combination, administered to neonate mice, can trigger apoptosis and whether behavioral deficits occur later in adulthood...
  50. pmc Identification of a fluorescent general anesthetic, 1-aminoanthracene
    Christopher A Butts
    Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 106:6501-6. 2009
    ..Thus, 1-AMA provides an unprecedented opportunity for studying general anesthetic distribution in vivo at the cellular and subcellular levels...
  51. ncbi Comparison of plasma compartment versus two methods for effect compartment--controlled target-controlled infusion for propofol
    M M Struys
    Department of Anesthesia, the University Hospital of Gent, Belgium
    Anesthesiology 92:399-406. 2000
    ..The authors tested this by comparing the performance of three control algorithms: plasmacontrol TCI versus two algorithms for effect-site control TCI...
  52. ncbi Population pharmacokinetics of propofol: a multicenter study
    J Schuttler
    Department of Anesthesiology, Friedrich Alexander University of Erlangen Nuremberg, Germany
    Anesthesiology 92:727-38. 2000
    Target-controlled infusion is an increasingly common type of administration for propofol. This method requires accurate knowledge of pharmacokinetics, including the effects of age and weight...
  53. ncbi Propofol alone titrated to deep sedation versus propofol in combination with opioids and/or benzodiazepines and titrated to moderate sedation for colonoscopy
    Megan E VanNatta
    Department of Medicine, Division of Gastroenterology, Indiana University School of Medicine, Indianapolis Indiana 46202, USA
    Am J Gastroenterol 101:2209-17. 2006
    b>Propofol by nonanesthesiologists is controversial because the drug is commonly used to produce deep sedation or general anesthesia...
  54. doi Propofol protects hepatic L02 cells from hydrogen peroxide-induced apoptosis via activation of extracellular signal-regulated kinases pathway
    Hao Wang
    Department of Anesthesiology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, People s Republic of China
    Anesth Analg 107:534-40. 2008
    b>Propofol protects cells against ischemia/reperfusion injury in several organs, but there are few reports of its effect on liver epithelial cells...
  55. ncbi Ondansetron pretreatment to alleviate pain on propofol injection: a randomized, controlled, double-blinded study
    S P Ambesh
    Department of Anesthesiology and Critical Care Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Anesth Analg 89:197-9. 1999
    ..design to study the effect of ondansetron (OND) pretreatment on the pain produced by the IV injection of propofol. Eighty patients were randomly assigned to one of two groups: Group I received 2 mL of IV 0...
  56. ncbi Dose requirement and complications of diluted and undiluted propofol for deep sedation in endoscopic retrograde cholangiopancreatography
    Somchai Amornyotin
    Department of Anesthesiology and Siriraj GI Endoscopy Center, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
    Hepatobiliary Pancreat Dis Int 10:313-8. 2011
    In general, the dose requirement and complications of propofol are lower when used in the diluted form than in the undiluted form...
  57. pmc Potential network mechanisms mediating electroencephalographic beta rhythm changes during propofol-induced paradoxical excitation
    Michelle M McCarthy
    Department of Mathematics and Statistics, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 28:13488-504. 2008
    b>Propofol, like most general anesthetic drugs, can induce both behavioral and electroencephalographic (EEG) manifestations of excitation, rather than sedation, at low doses...
  58. doi Propofol post-conditioning induced long-term neuroprotection and reduced internalization of AMPAR GluR2 subunit in a rat model of focal cerebral ischemia/reperfusion
    Haiyun Wang
    Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China
    J Neurochem 119:210-9. 2011
    We previously reported that propofol (20 mg/kg/h) post-conditioning provided acute (up to 24 h) neuroprotection in rats with transient middle cerebral artery occlusion...
  59. ncbi Comparison of stress hormone response, interleukin-6 and anaesthetic characteristics of two anaesthetic techniques: volatile induction and maintenance of anaesthesia using sevoflurane versus total intravenous anaesthesia using propofol and remifentanil
    C H Ihn
    Department of Anaesthesiology and Pain Medicine, St Vincent Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
    J Int Med Res 37:1760-71. 2009
    ..induction and maintenance of anaesthesia (VIMA) with sevoflurane or total intravenous anaesthesia (TIVA) with propofol and remifentanil...
  60. ncbi Propofol sedation for upper gastrointestinal endoscopy in patients with liver cirrhosis as an alternative to midazolam to avoid acute deterioration of minimal encephalopathy: a randomized, controlled study
    Andrea Riphaus
    Department of Internal Medicine I, Gastroenterology and Interventional Endoscopy, Hospital Siloah, Hannover, Germany
    Scand J Gastroenterol 44:1244-51. 2009
    ..The aim of this randomized, controlled study was to assess whether the use of the short-acting propofol as a sedative for GI endoscopy could prevent the exacerbation of minimal HE in patients with liver cirrhosis.
  61. doi Balanced propofol sedation for therapeutic GI endoscopic procedures: a prospective, randomized study
    Chang Kyun Lee
    Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea
    Gastrointest Endosc 73:206-14. 2011
    There are few controlled studies on balanced propofol sedation (BPS) for therapeutic endoscopy.
  62. ncbi Assessment of surgical stress during general anaesthesia
    M Huiku
    Clinical Research, GE Healthcare Finland Oy, PO Box 900, FI 00031 GE, Helsinki, Finland
    Br J Anaesth 98:447-55. 2007
    ..No objective measures of the adequacy of analgesia exist. We aimed at developing a simple numerical measure of the level of surgical stress in an anaesthetized patient...
  63. ncbi Sedation with target-controlled propofol infusion during shoulder surgery under interscalene brachial plexus block in the sitting position: report of a series of 140 patients
    V Souron
    Clinique Generale, Department of Anaesthesiology, Annecy, France
    Eur J Anaesthesiol 22:853-7. 2005
    The aim of this study was to assess target-controlled propofol infusion as a technique of sedation for shoulder surgery under interscalene brachial plexus block in the sitting position and to evaluate the effect of sedation on hypotensive/..
  64. doi Functional magnetic resonance imaging (fMRI) in children sedated with propofol or midazolam
    Marco Gemma
    Anesthesia and Intensive Care Unit, Head and Neck Department, Vita Salute University, San Raffaele Scientific Institute, Milan, Italy
    J Neurosurg Anesthesiol 21:253-8. 2009
    ..This study compares the effect of propofol and midazolam on the fMRI auditory activation pattern in children...
  65. doi Meanfield modeling of propofol-induced changes in spontaneous EEG rhythms
    Rikkert Hindriks
    Department of Clinical Neurophysiology, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, 7500 AE Enschede, The Netherlands
    Neuroimage 60:2323-34. 2012
    During the maintenance period of propofol-induced general anesthesia, specific changes in spontaneous EEG rhythms can be observed. These comprise increased delta and theta power and the emergence of alpha oscillations over frontal regions...
  66. ncbi Effect of dexmedetomidine on propofol requirements in healthy subjects
    S Dutta
    Clinical Pharmacokinetics Department, Abbott Laboratories, 100 Abbott Park Road, Department 4PK, AP13A 3, Abbott Park, Illinois 60064 6104, USA
    J Pharm Sci 90:172-81. 2001
    Dexmedetomidine-propofol pharmacodynamic interaction was evaluated in nine healthy subjects in a crossover design...
  67. doi Early phase pharmacokinetics but not pharmacodynamics are influenced by propofol infusion rate
    Kenichi Masui
    Department of Anesthesiology, National Defense Medical College, Tokorozawa, Japan
    Anesthesiology 111:805-17. 2009
    ..This study examined the influence of the administration rate and other covariates on early phase kinetics and dynamics of propofol by using the enlarged structural pharmacokinetic model.
  68. doi Propofol attenuation of hydrogen peroxide-mediated oxidative stress and apoptosis in cultured cardiomyocytes involves haeme oxygenase-1
    J J Xu
    Renmin Hospital of Wuhan University, Department of Anesthesiology, Anesthesiology Research Laboratory, Wuhan, PR China
    Eur J Anaesthesiol 25:395-402. 2008
    Our aim was to investigate the cytoprotective effect of propofol against hydrogen peroxide (H2O2)-mediated injury and the effects on the haeme oxygenase-1 system, which is a possible new cytoprotective pathway of propofol.
  69. doi Effects of dexmedetomidine and propofol on lower esophageal sphincter and gastroesophageal pressure gradient in healthy volunteers
    Alparslan Turan
    Department of Outcomes Research, The Cleveland Clinic, Cleveland, OH 44195, USA
    Anesthesiology 112:19-24. 2010
    ..Therefore, the authors compared LESP and GEPG during dexmedetomidine and propofol sedation.
  70. pmc Rapid fragmentation of neuronal networks at the onset of propofol-induced unconsciousness
    Laura D Lewis
    Department of Brain and Cognitive Sciences, Harvard Massachusetts Institute of Technology Division of Health Sciences and Technology, and Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 109:E3377-86. 2012
    ..We show that propofol-induced unconsciousness occurs within seconds of the abrupt onset of a slow (<1 Hz) oscillation in the local ..
  71. ncbi Propofol-block of SK channels in reticular thalamic neurons enhances GABAergic inhibition in relay neurons
    Shui Wang Ying
    C V Starr Laboratory for Molecular Neuropharmacology, Deptartment of Anesthesiology A 1050, Weill Medical College, Cornell University, 1300 York Ave, New York, NY 10021, USA
    J Neurophysiol 93:1935-48. 2005
    ..We investigated presynaptic actions of the intravenous anesthetic propofol in RTN neurons, using RTN-retained and RTN-removed brain slices...
  72. ncbi Deep sedation with propofol for children undergoing ambulatory magnetic resonance imaging of the brain: experience from a pediatric intensive care unit
    Rashed A Hasan
    Department of Pediatrics, Michigan State University, Hurley Medical Center, Flint, MI 48503, USA
    Pediatr Crit Care Med 4:454-8. 2003
    Use of intravenous propofol sedation to facilitate completion of magnetic resonance imaging of the brain in children.
  73. ncbi Anti-inflammatory and antioxidative effects of propofol on lipopolysaccharide-activated macrophages
    Ruei Ming Chen
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, No 250, Wu Hsing St, Taipei 110, Taiwan
    Ann N Y Acad Sci 1042:262-71. 2005
    ..During sepsis, inflammatory cytokines and nitric oxide (NO) can be overproduced, causing tissue and cell injury. Propofol is an intravenous agent used for sedation of ICU patients...
  74. ncbi Prevention of pain due to injection of propofol with IV administration of lidocaine 40 mg + metoclopramide 2.5, 5, or 10 mg or saline: a randomized, double-blind study in Japanese adult surgical patients
    Yoshitaka Fujii
    First Department of Anesthesiology, Toho University School of Medicine, Tokyo, Japan
    Clin Ther 29:856-61. 2007
    Pain on injection is a recognized adverse event (AE) with propofol, an agent used to induce general anesthesia in surgical patients...
  75. ncbi Propofol-associated hypertriglyceridemia and pancreatitis in the intensive care unit: an analysis of frequency and risk factors
    John W Devlin
    School of Pharmacy, Northeastern University, and the Department of Pharmacy, Tufts New England Medical Center, Boston, Massachusetts 02115, USA
    Pharmacotherapy 25:1348-52. 2005
    To characterize the frequency, severity, risk factors, and clinician response to propofol-associated hypertriglyceridemia and hypertriglyceridemia-associated pancreatitis.
  76. ncbi Propofol inhibits phosphorylation of N-methyl-D-aspartate receptor NR1 subunits in neurons
    Seth Kingston
    Department of Anesthesiology, University of Missouri Kansas City School of Medicine, Saint Luke s Hospital, Kansas City, Missouri 64108, USA
    Anesthesiology 104:763-9. 2006
    ..It is currently unknown whether anesthetics have any modulatory effects on NMDAR NR1 subunit phosphorylation...
  77. ncbi Propofol: the challenges of formulation
    Max T Baker
    Department of Anesthesia, The University of Iowa College of Medicine, 52242 1009, USA
    Anesthesiology 103:860-76. 2005
    b>Propofol is a potent lipophilic anesthetic that was initially formulated in Cremophor El for human use...
  78. ncbi The pharmacodynamic effects of a lower-lipid emulsion of propofol: a comparison with the standard propofol emulsion
    Dajun Song
    Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9068, USA
    Anesth Analg 98:687-91, table of contents. 2004
    Using a randomized, double-blind protocol design, we compared a new lower-lipid emulsion of propofol (Ampofol) containing propofol 1%, soybean oil 5%, and egg lecithin 0...
  79. ncbi Peri-intubation cardiovascular response during low dose remifentanil or sufentanil administration in association with propofol TCI. A double blind comparison
    E Iannuzzi
    Department of Anaesthesiological, Surgical and Emergency Sciences, Second University of Naples, Naples, Italy
    Minerva Anestesiol 70:109-15. 2004
    The aim of this study was to compare the effects on cardiovascular modifications induced by tracheal intubation when low dose infusion of remifentanil or sufentanil are used in association with propofol target controlled infusion.
  80. pmc Anesthetic properties of a propofol microemulsion in dogs
    Timothy E Morey
    Department of Anesthesiology, University of Florida, Gainesville, FL 32610 0254, USA
    Anesth Analg 103:882-7. 2006
    Microemulsions of propofol with nanometer droplet diameter are alternatives to soybean macroemulsions for inducing anesthesia, and may have important advantages. We used a propofol (10 mg/mL) microemulsion (particle diameter 24.5 +/- 0...
  81. ncbi The utility of the bispectral index in procedural sedation with propofol in the emergency department
    James R Miner
    Department of Emergency Medicine, Hennepin County Medical Center, 701 Park Avenue South, Minneapolis, MN 55415, USA
    Acad Emerg Med 12:190-6. 2005
    ..The bispectral index (BIS) may be a useful monitor to predict the level of awareness in patients undergoing procedural sedation in the emergency department (ED)...
  82. ncbi Propofol pharmacokinetics and pharmacodynamics for depth of sedation in nonventilated infants after major craniofacial surgery
    Mariska Y M Peeters
    Department of Clinical Pharmacy, St Antonius Hospital, Nieuwegein, The Netherlands
    Anesthesiology 104:466-74. 2006
    To support safe and effective use of propofol in nonventilated children after major surgery, a model for propofol pharmacokinetics and pharmacodynamics is described.
  83. ncbi Auditory processing during deep propofol sedation and recovery from unconsciousness
    Stefan Koelsch
    Max Planck Institute for Human Cognitive and Brain Sciences, Independent Junior Research Group Neurocognition of Music, Stephanstr 1a, 04103 Leipzig, Germany
    Clin Neurophysiol 117:1746-59. 2006
    Using evoked potentials, this study investigated effects of deep propofol sedation, and effects of recovery from unconsciousness, on the processing of auditory information with stimuli suited to elicit a physical MMN, and a (music-..
  84. ncbi A comparison of the sedative, hemodynamic, and respiratory effects of dexmedetomidine and propofol in children undergoing magnetic resonance imaging
    Ahmet Koroglu
    Department of Anesthesiology and Reanimation, Inonu University, Medical Faculty, 44315 Malatya, Turkey
    Anesth Analg 103:63-7, table of contents. 2006
    We compared the sedative, hemodynamic, and respiratory effects of dexmedetomidine and propofol in children undergoing magnetic resonance imaging procedures...
  85. ncbi Changes in concentrations of free propofol by modification of the solution
    Michiaki Yamakage
    Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo, Hokkaido 060 8543, Japan
    Anesth Analg 101:385-8, table of contents. 2005
    Because free propofol is thought to be responsible for pain on injection, we investigated the changes in concentrations of free propofol by modifying two kinds of propofol products in a medium- and long-chain triglyceride (MCT/LCT) ..
  86. doi A comparison of pretreatment with fentanyl and lidocaine preceded by venous occlusion for reducing pain on injection of propofol: a prospective, randomized, double-blind, placebo-controlled study in adult Japanese surgical patients
    Yoshitaka Fujii
    First Department of Anesthesiology, Toho University School of Medicine, Tokyo, Japan
    Clin Ther 31:2107-12. 2009
    Pain on injection is a recognized adverse effect of propofol, an agent used to induce general anesthesia in surgical patients. Pretreatment with fentanyl has been reported to be effective in reducing propofol-induced pain.
  87. doi Subanesthetic doses of propofol induce neuroapoptosis in the infant mouse brain
    Davide Cattano
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, PO BOX 8134, St Louis, MO 63110, USA
    Anesth Analg 106:1712-4. 2008
    ..b>Propofol reportedly interacts with both gamma-aminobutyric acid type A and N-methyl-d-aspartate glutamate receptors, but ..
  88. ncbi A comparison of ketamine and lidocaine spray with propofol for the insertion of laryngeal mask airway in children: a double-blinded randomized trial
    Jae Hyon Bahk
    Department of Anesthesiology and Clinical Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Korea
    Anesth Analg 95:1586-9, table of contents. 2002
    ..005 mg/kg, 90 patients were randomly allocated to 1 of 2 main groups for the administration of either propofol or ketamine: 40 patients received 2.5, 3.0, 3.5, or 4...
  89. pmc Pharmacokinetics and effects of propofol 6% for short-term sedation in paediatric patients following cardiac surgery
    Catherijne A J Knibbe
    Department of Clinical Pharmacy, St Antonius Hospital, PO Box 2500, 3430 EM Nieuwegein, The Netherlands
    Br J Clin Pharmacol 54:415-22. 2002
    This paper describes the pharmacokinetics and effects of propofol in short-term sedated paediatric patients.
  90. ncbi Is there a role of a small dose of propofol in the treatment of laryngeal spasm?
    Gauhar Afshan
    Department of Anaesthesia, The Aga Khan University Hospital, Karachi, Pakistan
    Paediatr Anaesth 12:625-8. 2002
    b>Propofol has been found to depress the laryngeal reflexes. We studied whether this property could be utilized to relieve laryngeal spasm.
  91. doi Tracheal intubating conditions using propofol and remifentanil target-controlled infusion: a comparison of remifentanil EC50 for Glidescope and Macintosh
    F Ithnin
    Department of Women s Anaesthesia, KK Women s and Children s Hospital, Singapore, Singapore
    Eur J Anaesthesiol 26:223-8. 2009
    The combination remifentanil-propofol was used for tracheal intubation without muscle relaxant in patients with anticipated difficult airway...
  92. ncbi Co-administration of alfentanil-propofol improves laryngeal mask airway insertion compared to fentanyl-propofol
    Jacqueline K L Hui
    Department of Anaesthesia Intensive Care, The Chinese University of Hong Kong Prince, of Wales Hospital, Shatin, New Territories, Hong Kong, Peoples Republic of China
    Can J Anaesth 49:508-12. 2002
    ..We therefore compared the insertion conditions following co-administration of alfentanil-propofol with more commonly used fentanyl-propofol.
  93. ncbi Muscle relaxation does not alter hypnotic level during propofol anesthesia
    Robert Greif
    Department of Anesthesiology and Intensive Care Medicine, Donauspital SMZO, Vienna, Austria
    Anesth Analg 94:604-8; table of contents. 2002
    ..Ten volunteers were anesthetized with propofol at a target effect site concentration of 3.8 plus/minus 0.4 microg/mL...
  94. ncbi Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons
    D Bai
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Mol Pharmacol 59:814-24. 2001
    ..compounds that potentiate GABA(A) receptor function including the benzodiazepine, midazolam, and anesthetic, propofol, prolonged the duration of mIPSCs and increased tonic current amplitude in cultured neurons to different extents...
  95. doi Emergence times are similar with sevoflurane and total intravenous anesthesia: results of a multicenter RCT of patients scheduled for elective supratentorial craniotomy
    Enrico Lauta
    Anesthesia and Intensive Care Unit I, Azienda Ospedaliero Universitaria Consorziale Policlinico, Bari, Italy
    J Neurosurg Anesthesiol 22:110-8. 2010
    ..that inhalation anesthesia (sevoflurane/remifentanil--group S) reduces emergence time by 5 minutes compared with intravenous anesthesia (propofol/remifentanil--group P) in patients undergoing neurosurgery for supratentorial neoplasms.
  96. ncbi Comparison of the effects of sevoflurane and propofol on cooling and rewarming during deliberate mild hypothermia for neurosurgery
    T Iwata
    Department of Anesthesiology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    Br J Anaesth 90:32-8. 2003
    ..We therefore investigated possible differences between sevoflurane and propofol on the decrease and recovery of core temperature during deliberate mild hypothermia for neurosurgery.
  97. pmc Anesthetic propofol reduces endotoxic inflammation by inhibiting reactive oxygen species-regulated Akt/IKKβ/NF-κB signaling
    Chung Hsi Hsing
    Department of Anesthesiology, Chi Mei Medical Center, Tainan, Taiwan
    PLoS ONE 6:e17598. 2011
    Anesthetic propofol has immunomodulatory effects, particularly in the area of anti-inflammation. Bacterial endotoxin lipopolysaccharide (LPS) induces inflammation through toll-like receptor (TLR) 4 signaling...
  98. ncbi Development of a new generation of propofol
    Haibo Wang
    Department of Anesthesiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Curr Opin Anaesthesiol 20:311-5. 2007
    The current advance in development of a new generation of propofol and its clinical implications are reviewed.
  99. ncbi Less core hypothermia when anesthesia is induced with inhaled sevoflurane than with intravenous propofol
    T Ikeda
    Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Japan
    Anesth Analg 88:921-4. 1999
    ..Sevoflurane and propofol both inhibit central thermoregulatory control, thus causing vasodilation...
  100. ncbi Physical properties and stability of two emulsion formulations of propofol
    J Han
    School of Pharmaceutical Sciences, University of Nottingham, University Park, NG7 2RD, Nottingham, UK
    Int J Pharm 215:207-20. 2001
    We have compared the physical properties of two commercial emulsion formulations of the intravenous anaesthetic propofol, (Diprivan, AstraZeneca, and Propofol Intravenous Emulsion, Gensia Sicor Pharmaceuticals) which appear to differ ..
  101. ncbi Changes in respiratory pattern and arterial blood gases during sedation with propofol or midazolam in spinal anesthesia
    M Yamakage
    Department of Anesthesiology, Sapporo Medical University, School of Medicine, Hokkaido, Japan
    J Clin Anesth 11:375-9. 1999
    To investigate changes in respiratory pattern and arterial blood gases during sedation with propofol or midazolam in spinal anesthesia.

Research Grants80

  1. ANESTHETIC REACTIONS IN SURGERY
    Charles Louis; Fiscal Year: 1999
    ..MHS-triggering anesthetics with the RYR is modified by muscle metabolites and non-triggering anesthetics such as propofol. We will examine whether propofol, which neither triggers MH nor alters RYR activity, modifies the action of MH-..
  2. CENTRAL BAROREFLEX MECHANISMS OF ANESTHETIC ACTION
    MICHAEL ANDRESEN; Fiscal Year: 2000
    ..In these studies isoflurane and propofol depressed the bradycardia that follows MAP increase induced by iv phenyephrine in both intact and decerebrate ..
  3. RECOMBINANT/NATIVE GABAA RECEPTORS
    Robert MacDonald; Fiscal Year: 2002
    ..individual subtypes confer different sensitivities to GABAR modulators such as benzodiazepines, barbiturates, propofol, loreclezole, alcohol, furosemide, zinc, other divalent cations and lanthanum...
  4. Inflammation-induced changes in spinal GABA-A receptor signaling
    Michael S Gold; Fiscal Year: 2010
    ..mechanisms of persistent pain, 2) the clinical use of an array of general anesthetics such a isoflurane, propofol and etomidate, and 3) the development of novel therapeutic interventions for the treatment of pain...
  5. Potentiation of Glycine Receptors by Ethanol
    LUIS GERARDO AGUAYO; Fiscal Year: 2010
    ..Remarkably, it was shown that these sites did not participate in the modulation of GlyRs by propofol, isoflurane and long chain alcohols indicating a novel and selective new site for ethanol...
  6. General Anesthetic Sites in GABA-A Receptor Subunit Interfacial Pockets
    Stuart A Forman; Fiscal Year: 2010
    ..A (GABAA) receptors in the central nervous system are major targets of the potent general anesthetics etomidate, propofol, barbiturates, and neuroactive steroids...
  7. Multimodal Functional Imaging of Auditory Perception Under General Anesthesia
    PATRICK PURDON; Fiscal Year: 2007
    ..FMRI responses to perception of sound temporal envelope will be measured at varying levels of propofol anesthesia, ranging from light sedation to deep anesthesia, with simultaneous EEG...
  8. Potentiation of Glycine Receptors by Ethanol
    LUIS GERARDO AGUAYO; Fiscal Year: 2010
    ..Remarkably, it was shown that these sites did not participate in the modulation of GlyRs by propofol, isoflurane and long chain alcohols indicating a novel and selective new site for ethanol...
  9. The Role of the Amygdala in Anesthetic-Induced Amnesia
    MICHAEL ALKIRE; Fiscal Year: 2006
    ..learning in rats, that the basolateral amygdala (BL) is critically nvolved with mediating the amnesic effects of propofol general anesthesia. Propofol does not produce amnesia if the BL is lesioned...
  10. The Role of the Amygdala in Anesthetic-Induced Amnesia
    MICHAEL ALKIRE; Fiscal Year: 2003
    ..learning in rats, that the basolateral amygdala (BL) is critically nvolved with mediating the amnesic effects of propofol general anesthesia. Propofol does not produce amnesia if the BL is lesioned...
  11. Isoflurane: Identification of Key New Targets
    Aaron Fox; Fiscal Year: 2009
    ..Etomidate and propofol also inhibited the release machinery in PC12 cells, suggesting that inhibition of neurotransmitter release may be ..
  12. Isoflurane: Identification of Key New Targets
    Aaron P Fox; Fiscal Year: 2010
    ..Etomidate and propofol also inhibited the release machinery in PC12 cells, suggesting that inhibition of neurotransmitter release may be ..
  13. Mechanisms of anesthetic effects on tachykinin induced airway tone
    Charles Emala; Fiscal Year: 2007
    ..b>Propofol is known to allosterically enhance the activity of GABA at GABAA receptors in the brain and is recognized as the ..
  14. Mechanisms of anesthetic effects on tachykinin induced airway tone
    Charles W Emala; Fiscal Year: 2010
    ..b>Propofol is known to allosterically enhance the activity of GABA at GABAA receptors in the brain and is recognized as the ..
  15. Propofol Interactions with GABA-A Receptors
    MYLES AKABAS; Fiscal Year: 2009
    ..The long term goal of this project is to elucidate the molecular bases of general anesthesia. Propofol, a widely used intravenous general anesthetic, is the major focus of this project...
  16. Propofol Interactions with GABA-A Receptors
    MYLES AKABAS; Fiscal Year: 2007
    ..The long term goal of this project is to elucidate the molecular bases of general anesthesia. Propofol, a widely used intravenous general anesthetic, is the major focus of this project...
  17. Fluorinated Nanocarriers for the Delivery of Anesthetics and Hydrophobic Drugs
    Sandro Mecozzi; Fiscal Year: 2007
    ..to more rapidly induce anesthesia than is possible using inhalation methods, and a more rapid awakening than even propofol produces...
  18. Fluorinated Nanocarriers for the Delivery of Anesthetics and Hydrophobic Drugs
    Sandro Mecozzi; Fiscal Year: 2010
    ..to more rapidly induce anesthesia than is possible using inhalation methods, and a more rapid awakening than even propofol produces...
  19. Propofol and Protein Kinase C: Molecular Interactions in Cardiomyocytes
    DEREK DAMRON; Fiscal Year: 2007
    ..Our primary goal is to identify the cellular signaling pathways by which the intravenous anesthetic, propofol, acts as a ligand to activate PKCe, and to delineate the molecular mechanism by which interaction and activation ..
  20. CNS TARGETS OF PROPOFOL'S HYPNOTIC AND MEMORY EFFECTS
    ROBERT VESELIS; Fiscal Year: 2003
    ..We have shown that one such drug, propofol, has memory effects independent of sedation during behavioral testing...
  21. BRAIN AND SPINAL CORD CONTRIBUTIONS TO ANESTHETIC ACTION
    JOSEPH ANTOGNINI; Fiscal Year: 2005
    ..In the past grant cycle we determined that isoflurane and propofol action in the spinal cord depressed the ascending transmission of nociceptive impulses to the brain...
  22. SITES OF ACTION OF INHALATIONAL ANESTHETICS ON HPV
    James Baumgardner; Fiscal Year: 2001
    ..The proposed studies will investigate the quantitative effects of inhalational and injectable (Propofol) general anesthetics on each step of this triphasic response...
  23. THE ROLE OF EPSILON SUBUNIT IN GABAA RECEPTOR FUNCTION
    TIM HALES; Fiscal Year: 2003
    ..Human homomeric and heteromeric 5-HT3 receptors are modulated by the intravenous anesthetic propofol which is reported to have anti-emetic properties.
  24. Crosby_Gregory_Mechanisms of Post-Anesthetic CNS Dysfunction in Aging
    Gregory Crosby; Fiscal Year: 2009
    ..on dendritic spine morphogenesis, synaptogenesis, and neurogenesis to test the hypotheses that isoflurane but not propofol 1. causes sustained disruption of mechanisms underlying spine and synapse formation; and 2...
  25. Crosby_Gregory_Mechanisms of Post-Anesthetic CNS Dysfunction in Aging
    Gregory Crosby; Fiscal Year: 2010
    ..on dendritic spine morphogenesis, synaptogenesis, and neurogenesis to test the hypotheses that isoflurane but not propofol 1. causes sustained disruption of mechanisms underlying spine and synapse formation;and 2...
  26. Crosby_Gregory_Mechanisms of Post-Anesthetic CNS Dysfunction in Aging
    Gregory Crosby; Fiscal Year: 2009
    ..on dendritic spine morphogenesis, synaptogenesis, and neurogenesis to test the hypotheses that isoflurane but not propofol 1. causes sustained disruption of mechanisms underlying spine and synapse formation; and 2...
  27. Propofol and Protein Kinase C: Molecular Interactions in Cardiomyocytes
    DEREK DAMRON; Fiscal Year: 2009
    ..Our primary goal is to identify the cellular signaling pathways by which the intravenous anesthetic, propofol, acts as a ligand to activate PKCe, and to delineate the molecular mechanism by which interaction and activation ..