propofol

Summary

Summary: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206)

Top Publications

  1. ncbi Bispectral analysis measures sedation and memory effects of propofol, midazolam, isoflurane, and alfentanil in healthy volunteers
    P S Glass
    Department of Anesthesiology, Duke University, Durham, North Carolina 27710, USA
    Anesthesiology 86:836-47. 1997
  2. ncbi The general anesthetic propofol excites nociceptors by activating TRPV1 and TRPA1 rather than GABAA receptors
    Michael J M Fischer
    Institute of Physiology and Pathophysiology, University of Erlangen Nuremberg, Erlangen 91054, Germany
    J Biol Chem 285:34781-92. 2010
  3. ncbi Open-label, prospective, randomized comparison of propofol and sevoflurane for laryngeal mask anesthesia for magnetic resonance imaging in pediatric patients
    Iclal Ozdemir Kol
    Department of Anesthesiology, Cumhuriyet University School of Medicine, Sivas, Turkey
    Clin Ther 30:175-81. 2008
  4. ncbi Remifentanil target-controlled infusion vs propofol target-controlled infusion for conscious sedation for awake fibreoptic intubation: a double-blinded randomized controlled trial
    M R Rai
    Nuffield Department of Anaesthetics, Oxford Radcliffe NHS Trust, Headley Way, Headington, Oxford OX3 9DU, UK
    Br J Anaesth 100:125-30. 2008
  5. ncbi Dexmedetomidine-ketamine and propofol-ketamine combinations for anesthesia in spontaneously breathing pediatric patients undergoing cardiac catheterization
    Zeynep Tosun
    Department of Anesthesiology and Reanimation, Erciyes University School of Medicine, Kayseri, Turkey
    J Cardiothorac Vasc Anesth 20:515-9. 2006
  6. ncbi Changes in resting neural connectivity during propofol sedation
    Emmanuel A Stamatakis
    Division of Anaesthesia, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 5:e14224. 2010
  7. ncbi Reduction of pain during induction with target-controlled propofol and remifentanil
    J R Lee
    Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, 28, Yongon Dong, Jongno gu, Seoul 110 744, Korea
    Br J Anaesth 99:876-80. 2007
  8. ncbi The effect of lidocaine on the globule size distribution of propofol emulsions
    Jong Woo Park
    Department of Pharmaceutics, College of Pharmacy, Sungkyunkwan University, Suwon, South Korea
    Anesth Analg 97:769-71. 2003
  9. ncbi Comparison of recovery profile after ambulatory anesthesia with propofol, isoflurane, sevoflurane and desflurane: a systematic review
    Anil Gupta
    Department of Anesthesiology and Critical Care, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Anesth Analg 98:632-41, table of contents. 2004
  10. ncbi Breakdown of within- and between-network resting state functional magnetic resonance imaging connectivity during propofol-induced loss of consciousness
    Pierre Boveroux
    Department of Anesthesia and Intensive Care Medicine, University of Liege, Liege, Belgium
    Anesthesiology 113:1038-53. 2010

Research Grants

  1. ANESTHETIC REACTIONS IN SURGERY
    Charles Louis; Fiscal Year: 1999
  2. CENTRAL BAROREFLEX MECHANISMS OF ANESTHETIC ACTION
    MICHAEL ANDRESEN; Fiscal Year: 2000
  3. RECOMBINANT/NATIVE GABAA RECEPTORS
    Robert MacDonald; Fiscal Year: 2002
  4. Inflammation-induced changes in spinal GABA-A receptor signaling
    Michael S Gold; Fiscal Year: 2010
  5. Potentiation of Glycine Receptors by Ethanol
    LUIS GERARDO AGUAYO; Fiscal Year: 2010
  6. General Anesthetic Sites in GABA-A Receptor Subunit Interfacial Pockets
    Stuart A Forman; Fiscal Year: 2010
  7. Multimodal Functional Imaging of Auditory Perception Under General Anesthesia
    PATRICK PURDON; Fiscal Year: 2007
  8. Potentiation of Glycine Receptors by Ethanol
    LUIS GERARDO AGUAYO; Fiscal Year: 2010
  9. The Role of the Amygdala in Anesthetic-Induced Amnesia
    MICHAEL ALKIRE; Fiscal Year: 2003
  10. The Role of the Amygdala in Anesthetic-Induced Amnesia
    MICHAEL ALKIRE; Fiscal Year: 2006

Detail Information

Publications260 found, 100 shown here

  1. ncbi Bispectral analysis measures sedation and memory effects of propofol, midazolam, isoflurane, and alfentanil in healthy volunteers
    P S Glass
    Department of Anesthesiology, Duke University, Durham, North Carolina 27710, USA
    Anesthesiology 86:836-47. 1997
    ..This study was designed to evaluate this relation for four commonly used anesthetic drugs: propofol, midazolam, isoflurane, and alfentanil.
  2. ncbi The general anesthetic propofol excites nociceptors by activating TRPV1 and TRPA1 rather than GABAA receptors
    Michael J M Fischer
    Institute of Physiology and Pathophysiology, University of Erlangen Nuremberg, Erlangen 91054, Germany
    J Biol Chem 285:34781-92. 2010
    ..we identify distinct molecular mechanisms that mediate an activation of sensory neurons by 2,6-diisopropylphenol (propofol), a commonly used intravenous anesthetic known to elicit intense pain upon injection...
  3. ncbi Open-label, prospective, randomized comparison of propofol and sevoflurane for laryngeal mask anesthesia for magnetic resonance imaging in pediatric patients
    Iclal Ozdemir Kol
    Department of Anesthesiology, Cumhuriyet University School of Medicine, Sivas, Turkey
    Clin Ther 30:175-81. 2008
    ..Magnetic resonance imaging (MRI) for pediatric patients often requires deep sedation or anesthesia because they must remain completely immobile for a relatively long period to obtain high-quality images...
  4. ncbi Remifentanil target-controlled infusion vs propofol target-controlled infusion for conscious sedation for awake fibreoptic intubation: a double-blinded randomized controlled trial
    M R Rai
    Nuffield Department of Anaesthetics, Oxford Radcliffe NHS Trust, Headley Way, Headington, Oxford OX3 9DU, UK
    Br J Anaesth 100:125-30. 2008
    ..This study compares the suitability of remifentanil target-controlled infusion (TCI) to propofol TCI for conscious sedation during AFOI in patients with bona fide difficult airways.
  5. ncbi Dexmedetomidine-ketamine and propofol-ketamine combinations for anesthesia in spontaneously breathing pediatric patients undergoing cardiac catheterization
    Zeynep Tosun
    Department of Anesthesiology and Reanimation, Erciyes University School of Medicine, Kayseri, Turkey
    J Cardiothorac Vasc Anesth 20:515-9. 2006
    The purpose of this study was to compare the effects of dexmedetomidine-ketamine and propofol-ketamine combinations on hemodynamics, sedation level, and the recovery period in pediatric patients undergoing cardiac catheterization.
  6. ncbi Changes in resting neural connectivity during propofol sedation
    Emmanuel A Stamatakis
    Division of Anaesthesia, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 5:e14224. 2010
    ....
  7. ncbi Reduction of pain during induction with target-controlled propofol and remifentanil
    J R Lee
    Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, 28, Yongon Dong, Jongno gu, Seoul 110 744, Korea
    Br J Anaesth 99:876-80. 2007
    Pain on injection of propofol is unpleasant...
  8. ncbi The effect of lidocaine on the globule size distribution of propofol emulsions
    Jong Woo Park
    Department of Pharmaceutics, College of Pharmacy, Sungkyunkwan University, Suwon, South Korea
    Anesth Analg 97:769-71. 2003
    In this study, we sought to determine the globule size distribution of a propofol/lidocaine mixture as a function of lidocaine concentration and time elapsed after mixing in a standard formulation of propofol emulsion (Diprivan) and in a ..
  9. ncbi Comparison of recovery profile after ambulatory anesthesia with propofol, isoflurane, sevoflurane and desflurane: a systematic review
    Anil Gupta
    Department of Anesthesiology and Critical Care, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Anesth Analg 98:632-41, table of contents. 2004
    ..A second search strategy was used combining two of the words "propofol," "isoflurane," "sevoflurane," or "desflurane"...
  10. ncbi Breakdown of within- and between-network resting state functional magnetic resonance imaging connectivity during propofol-induced loss of consciousness
    Pierre Boveroux
    Department of Anesthesia and Intensive Care Medicine, University of Liege, Liege, Belgium
    Anesthesiology 113:1038-53. 2010
    ..Resting-state functional magnetic resonance imaging allows investigating whole-brain connectivity changes during pharmacological modulation of the level of consciousness...
  11. ncbi Pharmacokinetics and pharmacodynamics of propofol microemulsion and lipid emulsion after an intravenous bolus and variable rate infusion
    Kye Min Kim
    Department of Anesthesiology and Pain Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea
    Anesthesiology 106:924-34. 2007
    The aim of this trial was to evaluate the induction and recovery characteristics of microemulsion propofol (Aquafol; Daewon Pharmaceutical Co., Ltd., Seoul, Korea). Pharmacokinetics, pharmacodynamics, and safety profile were investigated...
  12. ncbi Ondansetron pretreatment to alleviate pain on propofol injection: a randomized, controlled, double-blinded study
    S P Ambesh
    Department of Anesthesiology and Critical Care Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Anesth Analg 89:197-9. 1999
    ..design to study the effect of ondansetron (OND) pretreatment on the pain produced by the IV injection of propofol. Eighty patients were randomly assigned to one of two groups: Group I received 2 mL of IV 0...
  13. ncbi Propofol anesthesia and sleep: a high-density EEG study
    Michael Murphy
    Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
    Sleep 34:283-91A. 2011
    ..We used high-density electroencephalography (hd-EEG) and source modeling to investigate the cortical processes underlying propofol anesthesia and compare them to sleep.
  14. ncbi Emergence times are similar with sevoflurane and total intravenous anesthesia: results of a multicenter RCT of patients scheduled for elective supratentorial craniotomy
    Enrico Lauta
    Anesthesia and Intensive Care Unit I, Azienda Ospedaliero Universitaria Consorziale Policlinico, Bari, Italy
    J Neurosurg Anesthesiol 22:110-8. 2010
    ..that inhalation anesthesia (sevoflurane/remifentanil--group S) reduces emergence time by 5 minutes compared with intravenous anesthesia (propofol/remifentanil--group P) in patients undergoing neurosurgery for supratentorial neoplasms.
  15. ncbi Anti-inflammatory and antioxidative effects of propofol on lipopolysaccharide-activated macrophages
    Ruei Ming Chen
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, No 250, Wu Hsing St, Taipei 110, Taiwan
    Ann N Y Acad Sci 1042:262-71. 2005
    ..During sepsis, inflammatory cytokines and nitric oxide (NO) can be overproduced, causing tissue and cell injury. Propofol is an intravenous agent used for sedation of ICU patients...
  16. ncbi Subanesthetic doses of propofol induce neuroapoptosis in the infant mouse brain
    Davide Cattano
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, PO BOX 8134, St Louis, MO 63110, USA
    Anesth Analg 106:1712-4. 2008
    ..b>Propofol reportedly interacts with both gamma-aminobutyric acid type A and N-methyl-d-aspartate glutamate receptors, but ..
  17. ncbi Comparison of the effects of sevoflurane and propofol on cooling and rewarming during deliberate mild hypothermia for neurosurgery
    T Iwata
    Department of Anesthesiology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan
    Br J Anaesth 90:32-8. 2003
    ..We therefore investigated possible differences between sevoflurane and propofol on the decrease and recovery of core temperature during deliberate mild hypothermia for neurosurgery...
  18. ncbi The utility of the bispectral index in procedural sedation with propofol in the emergency department
    James R Miner
    Department of Emergency Medicine, Hennepin County Medical Center, 701 Park Avenue South, Minneapolis, MN 55415, USA
    Acad Emerg Med 12:190-6. 2005
    ..The bispectral index (BIS) may be a useful monitor to predict the level of awareness in patients undergoing procedural sedation in the emergency department (ED)...
  19. ncbi Peri-intubation cardiovascular response during low dose remifentanil or sufentanil administration in association with propofol TCI. A double blind comparison
    E Iannuzzi
    Department of Anaesthesiological, Surgical and Emergency Sciences, Second University of Naples, Naples, Italy
    Minerva Anestesiol 70:109-15. 2004
    ..induced by tracheal intubation when low dose infusion of remifentanil or sufentanil are used in association with propofol target controlled infusion...
  20. ncbi Anesthetic propofol reduces endotoxic inflammation by inhibiting reactive oxygen species-regulated Akt/IKKβ/NF-κB signaling
    Chung Hsi Hsing
    Department of Anesthesiology, Chi Mei Medical Center, Tainan, Taiwan
    PLoS ONE 6:e17598. 2011
    Anesthetic propofol has immunomodulatory effects, particularly in the area of anti-inflammation. Bacterial endotoxin lipopolysaccharide (LPS) induces inflammation through toll-like receptor (TLR) 4 signaling...
  21. ncbi A comparison of pretreatment with fentanyl and lidocaine preceded by venous occlusion for reducing pain on injection of propofol: a prospective, randomized, double-blind, placebo-controlled study in adult Japanese surgical patients
    Yoshitaka Fujii
    First Department of Anesthesiology, Toho University School of Medicine, Tokyo, Japan
    Clin Ther 31:2107-12. 2009
    Pain on injection is a recognized adverse effect of propofol, an agent used to induce general anesthesia in surgical patients. Pretreatment with fentanyl has been reported to be effective in reducing propofol-induced pain.
  22. ncbi Co-administration of alfentanil-propofol improves laryngeal mask airway insertion compared to fentanyl-propofol
    Jacqueline K L Hui
    Department of Anaesthesia Intensive Care, The Chinese University of Hong Kong Prince, of Wales Hospital, Shatin, New Territories, Hong Kong, Peoples Republic of China
    Can J Anaesth 49:508-12. 2002
    ..We therefore compared the insertion conditions following co-administration of alfentanil-propofol with more commonly used fentanyl-propofol...
  23. ncbi Tracheal intubating conditions using propofol and remifentanil target-controlled infusion: a comparison of remifentanil EC50 for Glidescope and Macintosh
    F Ithnin
    Department of Women s Anaesthesia, KK Women s and Children s Hospital, Singapore, Singapore
    Eur J Anaesthesiol 26:223-8. 2009
    The combination remifentanil-propofol was used for tracheal intubation without muscle relaxant in patients with anticipated difficult airway...
  24. ncbi Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons
    D Bai
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Mol Pharmacol 59:814-24. 2001
    ..compounds that potentiate GABA(A) receptor function including the benzodiazepine, midazolam, and anesthetic, propofol, prolonged the duration of mIPSCs and increased tonic current amplitude in cultured neurons to different extents...
  25. ncbi Deep sedation with propofol for children undergoing ambulatory magnetic resonance imaging of the brain: experience from a pediatric intensive care unit
    Rashed A Hasan
    Department of Pediatrics, Michigan State University, Hurley Medical Center, Flint, MI 48503, USA
    Pediatr Crit Care Med 4:454-8. 2003
    Use of intravenous propofol sedation to facilitate completion of magnetic resonance imaging of the brain in children.
  26. ncbi The pharmacodynamic effects of a lower-lipid emulsion of propofol: a comparison with the standard propofol emulsion
    Dajun Song
    Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9068, USA
    Anesth Analg 98:687-91, table of contents. 2004
    Using a randomized, double-blind protocol design, we compared a new lower-lipid emulsion of propofol (Ampofol) containing propofol 1%, soybean oil 5%, and egg lecithin 0...
  27. ncbi Changes in concentrations of free propofol by modification of the solution
    Michiaki Yamakage
    Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo, Hokkaido 060 8543, Japan
    Anesth Analg 101:385-8, table of contents. 2005
    Because free propofol is thought to be responsible for pain on injection, we investigated the changes in concentrations of free propofol by modifying two kinds of propofol products in a medium- and long-chain triglyceride (MCT/LCT) ..
  28. ncbi Propofol-associated hypertriglyceridemia and pancreatitis in the intensive care unit: an analysis of frequency and risk factors
    John W Devlin
    School of Pharmacy, Northeastern University, and the Department of Pharmacy, Tufts New England Medical Center, Boston, Massachusetts 02115, USA
    Pharmacotherapy 25:1348-52. 2005
    To characterize the frequency, severity, risk factors, and clinician response to propofol-associated hypertriglyceridemia and hypertriglyceridemia-associated pancreatitis.
  29. ncbi Propofol: the challenges of formulation
    Max T Baker
    Department of Anesthesia, The University of Iowa College of Medicine, 52242 1009, USA
    Anesthesiology 103:860-76. 2005
    b>Propofol is a potent lipophilic anesthetic that was initially formulated in Cremophor El for human use...
  30. ncbi Prevention of pain due to injection of propofol with IV administration of lidocaine 40 mg + metoclopramide 2.5, 5, or 10 mg or saline: a randomized, double-blind study in Japanese adult surgical patients
    Yoshitaka Fujii
    First Department of Anesthesiology, Toho University School of Medicine, Tokyo, Japan
    Clin Ther 29:856-61. 2007
    Pain on injection is a recognized adverse event (AE) with propofol, an agent used to induce general anesthesia in surgical patients...
  31. ncbi Development of a new generation of propofol
    Haibo Wang
    Department of Anesthesiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Curr Opin Anaesthesiol 20:311-5. 2007
    The current advance in development of a new generation of propofol and its clinical implications are reviewed.
  32. ncbi A comparison of ketamine and lidocaine spray with propofol for the insertion of laryngeal mask airway in children: a double-blinded randomized trial
    Jae Hyon Bahk
    Department of Anesthesiology and Clinical Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Korea
    Anesth Analg 95:1586-9, table of contents. 2002
    ..005 mg/kg, 90 patients were randomly allocated to 1 of 2 main groups for the administration of either propofol or ketamine: 40 patients received 2.5, 3.0, 3.5, or 4...
  33. ncbi Anesthetic properties of a propofol microemulsion in dogs
    Timothy E Morey
    Department of Anesthesiology, University of Florida, Gainesville, FL 32610-0254, USA
    Anesth Analg 103:882-7. 2006
    Microemulsions of propofol with nanometer droplet diameter are alternatives to soybean macroemulsions for inducing anesthesia, and may have important advantages. We used a propofol (10 mg/mL) microemulsion (particle diameter 24.5 +/- 0...
  34. ncbi Muscle relaxation does not alter hypnotic level during propofol anesthesia
    Robert Greif
    Department of Anesthesiology and Intensive Care Medicine, Donauspital-SMZO, Vienna, Austria
    Anesth Analg 94:604-8; table of contents. 2002
    ..Ten volunteers were anesthetized with propofol at a target effect site concentration of 3.8 plus/minus 0.4 microg/mL...
  35. ncbi Auditory processing during deep propofol sedation and recovery from unconsciousness
    Stefan Koelsch
    Max Planck Institute for Human Cognitive and Brain Sciences, Independent Junior Research Group Neurocognition of Music, Stephanstr 1a, 04103 Leipzig, Germany
    Clin Neurophysiol 117:1746-59. 2006
    Using evoked potentials, this study investigated effects of deep propofol sedation, and effects of recovery from unconsciousness, on the processing of auditory information with stimuli suited to elicit a physical MMN, and a (music-..
  36. ncbi Pharmacokinetics and effects of propofol 6% for short-term sedation in paediatric patients following cardiac surgery
    Catherijne A J Knibbe
    Department of Clinical Pharmacy, St Antonius Hospital, PO Box 2500, 3430 EM Nieuwegein, The Netherlands
    Br J Clin Pharmacol 54:415-22. 2002
    This paper describes the pharmacokinetics and effects of propofol in short-term sedated paediatric patients.
  37. ncbi A comparison of the sedative, hemodynamic, and respiratory effects of dexmedetomidine and propofol in children undergoing magnetic resonance imaging
    Ahmet Koroglu
    Department of Anesthesiology and Reanimation, Inonu University, Medical Faculty, 44315 Malatya, Turkey
    Anesth Analg 103:63-7, table of contents. 2006
    We compared the sedative, hemodynamic, and respiratory effects of dexmedetomidine and propofol in children undergoing magnetic resonance imaging procedures...
  38. ncbi Propofol inhibits phosphorylation of N-methyl-D-aspartate receptor NR1 subunits in neurons
    Seth Kingston
    Department of Anesthesiology, University of Missouri-Kansas City School of Medicine, Saint Luke's Hospital, Kansas City, Missouri 64108, USA
    Anesthesiology 104:763-9. 2006
    ..METHODS: The possible effect of a general anesthetic propofol on phosphorylation of NR1 subunits at serine 897 (pNR1S897) and 896 (pNR1S896) was detected in cultured rat ..
  39. ncbi Propofol pharmacokinetics and pharmacodynamics for depth of sedation in nonventilated infants after major craniofacial surgery
    Mariska Y M Peeters
    Department of Clinical Pharmacy, St Antonius Hospital, Nieuwegein, The Netherlands
    Anesthesiology 104:466-74. 2006
    To support safe and effective use of propofol in nonventilated children after major surgery, a model for propofol pharmacokinetics and pharmacodynamics is described.
  40. ncbi The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers
    T W Schnider
    Institut für Anästhesie und Intensivmedizin, Inselspital, Universitat Bern, Switzerland
    Anesthesiology 88:1170-82. 1998
    Unresolved issues with propofol include whether the pharmacokinetics are linear with dose, are influenced by method of administration (bolus vs. infusion), or are influenced by age...
  41. ncbi Cortical and subcortical connectivity changes during decreasing levels of consciousness in humans: a functional magnetic resonance imaging study using propofol
    Roisin Ni Mhuircheartaigh
    Centre for Functional Magnetic Resonance of the Brain FMRIB, Department of Clinical Neurology and Nuffield Department of Anaesthetics, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    J Neurosci 30:9095-102. 2010
    ..2000; Mashour, 2006). We investigated the effects of propofol, widely used for anesthesia and sedation, on spontaneous and evoked cerebral activity using functional magnetic ..
  42. ncbi Is there a role of a small dose of propofol in the treatment of laryngeal spasm?
    Gauhar Afshan
    Department of Anaesthesia, The Aga Khan University Hospital, Karachi, Pakistan
    Paediatr Anaesth 12:625-8. 2002
    b>Propofol has been found to depress the laryngeal reflexes. We studied whether this property could be utilized to relieve laryngeal spasm.
  43. ncbi Brain functional integration decreases during propofol-induced loss of consciousness
    Jessica Schrouff
    Cyclotron Research Centre, University of Liege, Liege, Belgium
    Neuroimage 57:198-205. 2011
    ..In this paper, we tested the hypothesis that the loss of consciousness caused by propofol anesthesia is associated with a significant reduction in the capacity of the brain to integrate information...
  44. ncbi Tracheal intubating conditions using propofol and remifentanil target-controlled infusions
    A M Troy
    University Department of Anaesthesia, Glasgow Royal Infirmary, Glasgow UK
    Anaesthesia 57:1204-7. 2002
    ..the most appropriate dose of remifentanil required for intubation, using a steady effect-site concentration of propofol and without the use of neuromuscular blocking drugs...
  45. ncbi Effect of ondansetron pretreatment on pain after rocuronium and propofol injection: a randomised, double-blind controlled comparison with lidocaine
    M S Reddy
    Department of Anaesthesia, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074
    Anaesthesia 56:902-5. 2001
    ..study the effect of ondansetron pretreatment on the pain produced after intravenous injection of rocuronium and propofol in comparison with lidocaine, 60 patients were randomly assigned to one of three groups...
  46. ncbi Physical properties and stability of two emulsion formulations of propofol
    J Han
    School of Pharmaceutical Sciences, University of Nottingham, University Park, NG7 2RD, Nottingham, UK
    Int J Pharm 215:207-20. 2001
    We have compared the physical properties of two commercial emulsion formulations of the intravenous anaesthetic propofol, (Diprivan, AstraZeneca, and Propofol Intravenous Emulsion, Gensia Sicor Pharmaceuticals) which appear to differ ..
  47. ncbi Less core hypothermia when anesthesia is induced with inhaled sevoflurane than with intravenous propofol
    T Ikeda
    Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Japan
    Anesth Analg 88:921-4. 1999
    ..Sevoflurane and propofol both inhibit central thermoregulatory control, thus causing vasodilation...
  48. ncbi Binding of the general anesthetics propofol and halothane to human serum albumin. High resolution crystal structures
    A A Bhattacharya
    Biophysics Section, The Blackett Laboratory, Imperial College of Science, Technology and Medicine, London SW7 2BW, United Kingdom
    J Biol Chem 275:38731-8. 2000
    ..Here we describe high resolution crystal structures of HSA with two of the most widely used general anesthetics, propofol and halothane...
  49. ncbi Sevoflurane, but not propofol, significantly prolongs the Q-T interval
    A Kleinsasser
    Department of Anesthesiology and Critical Care Medicine, The Leopold Franzens University of Innsbruck, Austria
    Anesth Analg 90:25-7. 2000
    ..The aim of this study was to determine whether sevoflurane or propofol affects the Q-T interval...
  50. ncbi Changes in respiratory pattern and arterial blood gases during sedation with propofol or midazolam in spinal anesthesia
    M Yamakage
    Department of Anesthesiology, Sapporo Medical University, School of Medicine, Hokkaido, Japan
    J Clin Anesth 11:375-9. 1999
    To investigate changes in respiratory pattern and arterial blood gases during sedation with propofol or midazolam in spinal anesthesia.
  51. ncbi Effects of post-treatment with low-dose propofol on inflammatory responses to lipopolysaccharide-induced shock in conscious rats
    Bang Gee Hsu
    Department of Nephrology, Tzu Chi General Hospital, Hualien, Taiwan, Republic of China
    Clin Exp Pharmacol Physiol 32:24-9. 2005
    1. In the present study, we used a low dose of propofol (5 mg/kg per h) to investigate its effects on the pro-inflammatory cytokines (tumour necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-10) and changes in nitric oxide (NO) ..
  52. ncbi Intracranial pressure and cerebral hemodynamic in patients with cerebral tumors: a randomized prospective study of patients subjected to craniotomy in propofol-fentanyl, isoflurane-fentanyl, or sevoflurane-fentanyl anesthesia
    Kurt D Petersen
    Department of Anesthesia and Neurosurgery, Aarhus University Hospital, Denmark
    Anesthesiology 98:329-36. 2003
    ..METHODS: In an open-label study, 117 patients with supratentorial cerebral tumors were randomized to propofol-fentanyl (group 1), isoflurane-fentanyl (group 2), or sevoflurane-fentanyl anesthesia (group 3)...
  53. ncbi Dose effects of propofol on hemodynamic and cytokine responses to endotoxemia in rats
    Yasuhiro Takemoto
    Department of Anesthesiology and Intensive Care Medicine, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan
    J Anesth 19:40-4. 2005
    PURPOSE: Our previous studies have demonstrated that propofol inhibits hypotension, metabolic acidosis, and cytokine responses and reduces mortality in endotoxemic rats...
  54. ncbi Direct assessments of the antioxidant effects of propofol medium chain triglyceride/long chain triglyceride on the brain of stroke-prone spontaneously hypertensive rats using electron spin resonance spectroscopy
    Kyo Kobayashi
    Department of Clinical Care Medicine, Division of Anesthesiology, Kanagawa Dental College, Yokosuka, Kanagawa, Japan
    Anesthesiology 109:426-35. 2008
    Antioxidant anesthetics such as propofol (2,6-diisopropylphenol) directly inhibit lipid peroxidation via the generation of reactive oxygen species...
  55. ncbi Propofol total intravenous anesthesia for MRI in children
    Andrew G Usher
    Department of Anesthesiology and Pain Medicine, University of Alberta Hospital, Edmonton, Alberta T6G 2B7, Canada
    Paediatr Anaesth 15:23-8. 2005
    ..clinical signs of airway patency, airway intervention requirements and adverse events in 100 children receiving propofol total intravenous anesthesia for magnetic resonance imaging, with spontaneous ventilation and oxygenation via ..
  56. ncbi Effectiveness, safety, and pharmacokinetic and pharmacodynamic characteristics of microemulsion propofol in patients undergoing elective surgery under total intravenous anaesthesia
    J A Jung
    Department of Clinical Pharmacology and Therapeutics, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Pungnap 2 dong, Songpa Gu, Seoul 138 736, Korea
    Br J Anaesth 104:563-76. 2010
    The aims of this study were to investigate the effectiveness, safety, pharmacokinetics, and pharmacodynamics of microemulsion propofol, Aquafol (Daewon Pharmaceutical Co., Ltd, Seoul, Republic of Korea).
  57. ncbi Prevention of pain on injection of propofol: a comparison of lidocaine with different doses of paracetamol
    Hale Borazan
    Department of Anesthesiology and Reanimation, Selcuk University Medical Faculty, Konya, Turkey
    Eur J Anaesthesiol 27:253-7. 2010
    The aim of this study was to compare the efficacy of pretreatment with paracetamol 0.5 mg kg(-1), 1 mg kg(-1), 2 mg kg(-1) and lidocaine 0.5 mg kg(-1) for prevention of propofol induced pain.
  58. ncbi Death after re-exposure to propofol in a 3-year-old child: a case report
    Josef Holzki
    Department of Paediatric Anaesthesia, Children s Hospital of the City of Cologne, Cologne, Germany
    Paediatr Anaesth 14:265-70. 2004
    ..case report discusses the cause of death in a 3-year-old child who survived a high dose (20 mg x kg-1 x h-1) of propofol, infused over a period of 15 h, following which the patient developed a combined respiratory and metabolic ..
  59. ncbi A comparison of sedation with dexmedetomidine or propofol during shockwave lithotripsy: a randomized controlled trial
    Kenan Kaygusuz
    Department of Anesthesiology, Cumhuriyet University School of Medicine, Sivas, Turkey
    Anesth Analg 106:114-9, table of contents. 2008
    ..Extracorporeal shockwave lithotripsy (ESWL) is a minimal to mildly painful procedure that requires conscious sedation. We thus evaluated the utility of dexmedetomidine compared with propofol during an ESWL procedure.
  60. ncbi Double-blind, randomized comparison of ondansetron and intraoperative propofol to prevent postoperative nausea and vomiting
    T J Gan
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesthesiology 85:1036-42. 1996
    Breast surgery is associated with a high incidence of postoperative nausea and vomiting. Propofol and prophylactic administration of ondansetron are associated with a lower incidence of postoperative nausea and vomiting...
  61. ncbi The efficacy, side effects, and recovery characteristics of dexmedetomidine versus propofol when used for intraoperative sedation
    Shahbaz R Arain
    Department of Anesthesiology, Medical College of Wisconsin and VA Medical Center, Milwaukee, Wisconsin, USA
    Anesth Analg 95:461-6, table of contents. 2002
    We evaluated the cardio-respiratory effects of equi-sedative doses of dexmedetomidine and propofol for intraoperative sedation...
  62. ncbi Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats
    Kimberly D Statler
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neurotrauma 23:97-108. 2006
    ..in the controlled cortical impact model: diazepam, fentanyl, isoflurane, ketamine, morphine, pentobarbital, and propofol. Our objective was to provide insight into the relative degrees of neuroprotection provided by these agents in a ..
  63. ncbi The feasibility of bispectral index monitoring for intravenous sedation during dental treatment
    Satoshi Matsuzaki
    Department of Dental Anesthesiology, Nihon University School of Dentistry, Tokyo, Japan
    Anesth Prog 51:52-5. 2004
    ..4% +/- 9.2%. These findings suggest that bispectral index monitoring will prove effective for intravenous sedation during dental treatment...
  64. ncbi Changes in bispectral index values during lumbar arthrodesis
    E Barrera
    Eur J Anaesthesiol 22:392-3. 2005
  65. ncbi A randomized prospective comparative study of general versus epidural anesthesia for transcervical hysteroscopic endometrial resection
    M Goldenberg
    Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Israel
    Am J Obstet Gynecol 184:273-6. 2001
    ..3 +/- 157.1 mL, respectively; P < .0005). CONCLUSION: A significantly lower amount of glycine distention fluid was absorbed during endometrial resection in women who underwent the procedure with general rather than epidural anesthesia...
  66. ncbi The effect of music on preoperative sedation and the bispectral index
    Suleyman Ganidagli
    Department of Anesthesiology, Harran University, School of Medicine, Sanliurfa, Turkey
    Anesth Analg 101:103-6, table of contents. 2005
    ..In conclusion, listening to music during midazolam premedication is associated with an increase in sedation level in the preoperative period as reflected by a lower BIS value...
  67. ncbi The relationship between bispectral index and propofol during target-controlled infusion anesthesia: a comparative study between children and young adults
    Agnes Rigouzzo
    Service d anesthésie pédiatrique, Hopital Armand Trousseau, Paris, France
    Anesth Analg 106:1109-16, table of contents. 2008
    In this prospective study, we compared the relationship between propofol concentrations and bispectral index (BIS) in children versus young adults anesthetized with target-controlled infusion (TCI) of propofol.
  68. ncbi Xenon does not modify mivacurium induced neuromuscular block
    Oliver Kunitz
    Department of Anesthesiology, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Can J Anaesth 52:940-3. 2005
    The interaction between mivacurium and inhaled anesthetics is known, with the exception of xenon. We compared the pharmacodynamics of mivacurium during xenon anesthesia vs total iv anesthesia with propofol.
  69. ncbi Cerebral state monitor, a new small handheld EEG monitor for determining depth of anaesthesia: a clinical comparison with the bispectral index during day-surgery
    R E Anderson
    Department of Cardiothoracic Anaesthetics and Intensive Care, Karolinska Hospital, Stockholm, Sweden
    Eur J Anaesthesiol 23:208-12. 2006
    ..METHODS: Anaesthesia was induced with propofol and fentanyl (0.1 mg) in 38 patients undergoing general anaesthesia for routine day-surgery...
  70. ncbi Procedural sedation and analgesia: a review and new concepts
    Elizabeth L Bahn
    Department of Emergency Medicine, Madigan Army Medical Center, Fort Lewis, WA 984431, USA
    Emerg Med Clin North Am 23:503-17. 2005
    ..Both etomidate and propofol have emerged as useful drugs for PSA...
  71. ncbi Recovery after anesthesia for short pediatric oncology procedures: propofol and remifentanil compared with propofol, nitrous oxide, and sevoflurane
    Hilary R Glaisyer
    Department of Anaesthesia, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London, WC1N 3JH, United Kingdom
    Anesth Analg 100:959-63. 2005
    ..We compared the recovery characteristics of two anesthetic techniques: propofol with sevoflurane and nitrous oxide and a total IV technique using propofol and remifentanil...
  72. ncbi Average recovery time from a standardized intravenous sedation protocol and standardized discharge criteria in the general dental practice setting
    A J Lepere
    Faculty of Dentistry, University of Sydney, Sydney, Australia
    Anesth Prog 49:77-81. 2002
    ..The sedatives used were fentanyl, midazolam, and propofol. Results from 85 patients produced an average recovery time of 19 minutes...
  73. ncbi [Generalised clonic tonic seizures triggered by anaesthesia with propofol and sevoflurane]
    A Serrano-Pozo
    , , Sevilla, Spain
    Rev Neurol 39:693-4. 2004
  74. ncbi Xenon does not prolong neuromuscular block of rocuronium
    Oliver Kunitz
    Department of Anesthesiology, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Anesth Analg 99:1398-401; table of contents. 2004
    ..therefore compared the pharmacodynamics of rocuronium during xenon anesthesia versus a total IV anesthesia with propofol. Anesthesia was induced with propofol and remifentanil in both the xenon and propofol groups (each n = 20)...
  75. ncbi Narcotrend does not adequately detect the transition between awareness and unconsciousness in surgical patients
    Gerhard Schneider
    Department of Anesthesiology, Klinikum rechts der Isar, , Munich, Germany
    Anesthesiology 101:1105-11. 2004
    ..1 microg . kg . min), (2) sevoflurane-remifentanil (>/= 0.2 microg . kg . min), (3) propofol-remifentanil (</= 0.1 microg . kg . min), or (4) propofol-remifentanil (>/= 0.2 microg . kg . min)...
  76. ncbi Comparative evaluation of the Datex-Ohmeda S/5 Entropy Module and the Bispectral Index monitor during propofol-remifentanil anesthesia
    Gunter N Schmidt
    Department of Anesthesiology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Anesthesiology 101:1283-90. 2004
    ..The aim of the current study was to compare the accuracy of SE and RE with the Bispectral Index(R) monitor (BIS(R); Aspect Medical Systems, Newton, MA) during propofol-remifentanil anesthesia.
  77. ncbi No difference in emergence time and early cognitive function between sevoflurane-fentanyl and propofol-remifentanil in patients undergoing craniotomy for supratentorial intracranial surgery
    G Magni
    Department of Anesthesia and Intensive Care, Policlinico Umberto I, University of Rome La Sapienza, Rome, Italy
    J Neurosurg Anesthesiol 17:134-8. 2005
    Balanced anesthesia with sevoflurane-fentanyl has been widely accepted as anesthetic management for neurosurgery. Propofol-remifentanil regimen has been successfully used in various surgical settings, but a comprehensive comparison of ..
  78. ncbi Comparative analysis of costs of total intravenous anaesthesia with propofol and remifentanil vs. balanced anaesthesia with isoflurane and fentanyl
    J Epple
    Department of Anaesthesiology, University of Heidelberg, Heidelberg, Germany
    Eur J Anaesthesiol 18:20-8. 2001
    ..METHODS: One-hundred and twenty-four patients undergoing cataract surgery were randomized to either a propofol/remifentanil or an isoflurane/fentanyl group...
  79. ncbi Bispectral index monitoring does not improve early recovery of geriatric outpatients undergoing brief surgical procedures
    Edna Zohar
    Department of Anesthesiology, Meir Hospital, Kfar Saba, Israel
    Can J Anaesth 53:20-5. 2006
    ..METHODS: After a standardized induction with propofol and fentanyl, a laryngeal mask airway was inserted and sevoflurane was administered in combination with 60% ..
  80. ncbi Early recovery, cognitive function and costs of a desflurane inhalational vs. a total intravenous anaesthesia regimen in long-term surgery
    K D Röhm
    Department of Anesthesiology and Intensive Care Medicine, Klinikum Ludwigshafen, Ludwigshafen, Germany
    Acta Anaesthesiol Scand 50:14-8. 2006
    ..to compare time of recovery, return of cognitive function, post-anaesthetic care unit (PACU) stay and costs of a propofol/remifentanil (TIVA) with a desflurane/fentanyl-based anaesthesia (desflurane group) in surgical procedures ..
  81. ncbi Nocturnal episodic hypoxemia after ambulatory breast cancer surgery: comparison of sevoflurane and propofol-fentanyl anesthesia
    Gotaro Shirakami
    Day Surgery Unit, Kyoto University Hospital, Kyoto, Japan
    J Anesth 20:78-85. 2006
    ..of nocturnal episodic hypoxemia after ambulatory breast cancer surgery and its differences with sevoflurane and propofol anesthesia...
  82. ncbi Plasma concentrations of brain-derived neurotrophic factor in patients undergoing minor surgery: a randomized controlled trial
    Laszlo Vutskits
    Division of Anesthesiology, University Hospitals of Geneva, 24, Rue Micheli du Crest, CH 1211, Geneva 14, Switzerland
    Neurochem Res 33:1325-31. 2008
    ..Patients were randomly allocated to a general anesthetic with propofol induction and maintenance or with thiopental induction and isoflurane maintenance...
  83. ncbi Metoclopramide does not influence the frequency of propofol-induced spontaneous movements
    Fima Lenkovsky
    Department of Anesthesiology and Pain Management Service, Dallas Veterans Affairs Medical Center, Dallas, TX 75216, USA
    J Clin Anesth 19:530-3. 2007
    To evaluate the effects of metoclopramide on the frequency and severity of propofol-induced movements.
  84. ncbi Effect of total intravenous anaesthesia and balanced anaesthesia on the frequency of coughing during emergence from the anaesthesia
    M Hohlrieder
    Department of Anaesthesiology and Critical Care Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Br J Anaesth 99:587-91. 2007
    ..The effects of total intravenous anaesthesia (TIVA) and balanced anaesthesia (BAL) on coughing during emergence from the general anaesthesia have not yet been compared...
  85. ncbi Use of a target-controlled infusion system for propofol does not improve subjective assessment of anaesthetic depth by inexperienced anaesthesiologists
    B Rehberg
    Charite Universitatsmedizin Berlin, Campus Mitte, Klinik fur Anasthesiologie und Operative Intensivmedizin, Berlin, Germany
    Eur J Anaesthesiol 24:920-6. 2007
    ..Target-controlled infusion, via the calculated effect compartment concentrations, may help anaesthesiologists to titrate anaesthetic depth and to shorten recovery from anaesthesia...
  86. ncbi Hepatotoxicity after desflurane anesthesia in a 15-month-old child with Mobius syndrome after previous exposure to isoflurane
    Geneviève Côté
    Department of Anesthesiology, Centre hospitalier universitaire Sainte Justine, 3175 chemin de la Cote Sainte Catherine, Montreal, Quebec, Canada, H3T 1C5
    Anesthesiology 107:843-5. 2007
  87. ncbi Bispectral index monitored balanced anesthesia technique for pheochromocytoma resection
    Madan Mohan Maddali
    Department of Anesthesia, Royal Hospital, Muscat, Sultanate of Oman
    Paediatr Anaesth 17:688-92. 2007
    ..By titration of anesthesia depth, the stress response during resection could be avoided as well as postresection hypotension, without resort to additional pharmacological manipulation...
  88. ncbi A combination of total intravenous anesthesia and thoracic epidural for thymectomy in juvenile myasthenia gravis
    Oliver Bagshaw
    Department of Anaesthesia, Birmingham Children s Hospital, Birmingham, UK
    Paediatr Anaesth 17:370-4. 2007
    ..Two cases of thymectomy are presented where anesthesia was provided using a combination of TIVA and thoracic epidural analgesia. Both patients tolerated the technique well and had an uncomplicated perioperative course...
  89. ncbi Comparison of a propofol target-controlled infusion and inhalational sevoflurane for fibreoptic intubation under spontaneous ventilation
    M Bonnin
    CHU Clermont Ferrand, Services d Anesthésie Réanimation et de chirurgie maxillo faciale, Hotel Dieu, Clermont Ferrand, France et University Clermont1, Fac Médecine, Clermont Ferrand, France
    Acta Anaesthesiol Scand 51:54-9. 2007
    A propofol target-controlled infusion (TCI) is often proposed for the management of difficult airway intubation and fibreoptic intubation under anaesthesia and spontaneous ventilation. No data are available about sevoflurane...
  90. ncbi Supraspinal anesthesia: behavioral and electroencephalographic effects of intracerebroventricularly infused pentobarbital, propofol, fentanyl, and midazolam
    Izabela Jugovac
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Anesthesiology 105:764-78. 2006
    ..60 min later, 50-min infusion of pentobarbital (6.0 mg/h), fentanyl (0.75 microg/h), propofol (3.0 mg/h), or midazolam (0.24 mg/h) was initiated...
  91. ncbi Cerebral state index response to incision: a clinical study in day-surgical patients
    R E Anderson
    Department of Cardiothoracic Anaesthetics and Intensive Care, Karolinska Hospital, Stockholm, Sweden
    Acta Anaesthesiol Scand 50:749-53. 2006
    ..men and 23 females; mean age 52 (29-79) years, mean weight 77 (50-118) kg] were induced clinically with fentanyl/propofol with sevoflurane after placement of the laryngeal mask airway...
  92. ncbi Risk factors for nausea and vomiting following vitrectomy in adults
    K Nitahara
    Department of Anesthesiology, Fukuoka University School of Medicine, 7 45 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Eur J Anaesthesiol 24:166-70. 2007
    ..Little information is available regarding the risk factors for nausea and vomiting after vitrectomy in adults. In this study, we evaluated the potential risk factors for PONV after vitrectomy in adult patients...
  93. ncbi Hemodynamics in elderly coronary artery disease patients undergoing propofol sedation
    Joseph E Cillo
    Department of Oral and Maxillofacial Surgery, The University of Texas Southwestern Medical Center Parkland Memorial Hospital, Dallas, TX, USA
    J Oral Maxillofac Surg 64:1338-42. 2006
    ..study was to evaluate noninvasive intraoperative hemodynamics in an elderly population with coronary artery disease (CAD) undergoing midazolam/fentanyl intravenous sedation-analgesia, with or without propofol for dentoalveolar surgery.
  94. ncbi Sevoflurane-remifentanil versus propofol-remifentanil anesthesia at a similar bispectral level for off-pump coronary artery surgery: no evidence of reduced myocardial ischemia
    Jean Dominique Law-Koune
    Department of Anesthesiology, Foch Hospital, Suresnes, France
    J Cardiothorac Vasc Anesth 20:484-92. 2006
    ..was designed to compare postoperative troponin I (cTnI) concentrations after sevoflurane-remifentanil versus propofol-remifentanil anesthesia. DESIGN: Prospective, randomized single-blind clinical study...
  95. ncbi Propofol/remifentanil vs sevoflurane/remifentanil for long lasting surgical procedures: a randomised controlled trial
    J Hocker
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Schwanenweg 21, D 24105, Kiel, Germany
    Anaesthesia 61:752-7. 2006
    We compared the haemodynamics, emergence and recovery characteristics of total intravenous anaesthesia using propofol/remifentanil with sevoflurane/remifentanil anaesthesia, under bispectral index guidance, in 103 patients undergoing ..
  96. ncbi Comparison of remifentanil and fentanyl in anaesthesia for elective cardioversion
    F Maltepe
    Dokuz Eylul University Medical School, Department of Anesthesiology and Reanimation, Izmir, Turkey
    Anaesth Intensive Care 34:353-7. 2006
    ..study was designed to compare the recovery characteristics of remifentanil and fentanyl in combination with propofol for direct current cardioversion...
  97. ncbi Pharmacodynamic modelling of the bispectral index response to propofol-based anaesthesia during general surgery in children
    C Jeleazcov
    Department of Anaesthesiology, Universitatsklinikum Erlangen, Friedrich Alexander Universitat Erlangen Nurnberg, Krankenhausstr 12, 91054 Erlangen, Germany
    Br J Anaesth 100:509-16. 2008
    This study describes a pharmacodynamic model during general anaesthesia in children relating the bispectral index (BIS) response to the anaesthetic dosing of propofol, fentanyl, and remifentanil.
  98. ncbi Dental therapeutic practice patterns in the U.S. I. Anesthesia and sedation
    Paul A Moore
    Oral Health Science Institute, University of Pittsburgh School of Dental Medicine, USA
    Gen Dent 54:92-8. 2006
    ..9%). For intravenous conscious sedation, a three-drug technique using midazolam, fentanyl, and propofol was reported most commonly...
  99. ncbi Anesthesiologist-controlled versus patient-controlled propofol sedation for shockwave lithotripsy
    Jamal A Alhashemi
    Department of Anesthesia and Critical Care, King Abdulaziz University Hospital, P O Box 31648, Jeddah 21418, Saudi Arabia
    Can J Anaesth 53:449-55. 2006
    To compare anesthesiologist-controlled sedation (ACS) with patient-controlled sedation (PCS), with respect to propofol requirements, sedation, and recovery, in patients undergoing extracorporeal shockwave lithotripsy for urinary calculi.
  100. ncbi Early postoperative complications after intracranial surgery: comparison between total intravenous and balanced anesthesia
    Giuseppina Magni
    Department of Anesthesia and Intensive Care, Policlinico Umberto I, University of Rome La Sapienza, Italy
    J Neurosurg Anesthesiol 19:229-34. 2007
    ..occurring after neurosurgical procedures in patients anesthetized with either sevoflurane-fentanyl or propofol-remifentanil anesthesia...
  101. ncbi [Increase in bispectral index induced by antihyperalgesic dose of ketamine]
    K Chaaben
    , 4, rue de la Chine, 75970 Paris cedex 020, France
    Ann Fr Anesth Reanim 23:513-6. 2004
    ..The two patients were anaesthetised with a continuous infusion of remifentanil associated with propofol for one and isoflurane for the other...

Research Grants77

  1. ANESTHETIC REACTIONS IN SURGERY
    Charles Louis; Fiscal Year: 1999
    ..MHS-triggering anesthetics with the RYR is modified by muscle metabolites and non-triggering anesthetics such as propofol. We will examine whether propofol, which neither triggers MH nor alters RYR activity, modifies the action of MH-..
  2. CENTRAL BAROREFLEX MECHANISMS OF ANESTHETIC ACTION
    MICHAEL ANDRESEN; Fiscal Year: 2000
    ..In these studies isoflurane and propofol depressed the bradycardia that follows MAP increase induced by iv phenyephrine in both intact and decerebrate ..
  3. RECOMBINANT/NATIVE GABAA RECEPTORS
    Robert MacDonald; Fiscal Year: 2002
    ..individual subtypes confer different sensitivities to GABAR modulators such as benzodiazepines, barbiturates, propofol, loreclezole, alcohol, furosemide, zinc, other divalent cations and lanthanum...
  4. Inflammation-induced changes in spinal GABA-A receptor signaling
    Michael S Gold; Fiscal Year: 2010
    ..mechanisms of persistent pain, 2) the clinical use of an array of general anesthetics such a isoflurane, propofol and etomidate, and 3) the development of novel therapeutic interventions for the treatment of pain...
  5. Potentiation of Glycine Receptors by Ethanol
    LUIS GERARDO AGUAYO; Fiscal Year: 2010
    ..Remarkably, it was shown that these sites did not participate in the modulation of GlyRs by propofol, isoflurane and long chain alcohols indicating a novel and selective new site for ethanol...
  6. General Anesthetic Sites in GABA-A Receptor Subunit Interfacial Pockets
    Stuart A Forman; Fiscal Year: 2010
    ..A (GABAA) receptors in the central nervous system are major targets of the potent general anesthetics etomidate, propofol, barbiturates, and neuroactive steroids...
  7. Multimodal Functional Imaging of Auditory Perception Under General Anesthesia
    PATRICK PURDON; Fiscal Year: 2007
    ..FMRI responses to perception of sound temporal envelope will be measured at varying levels of propofol anesthesia, ranging from light sedation to deep anesthesia, with simultaneous EEG...
  8. Potentiation of Glycine Receptors by Ethanol
    LUIS GERARDO AGUAYO; Fiscal Year: 2010
    ..Remarkably, it was shown that these sites did not participate in the modulation of GlyRs by propofol, isoflurane and long chain alcohols indicating a novel and selective new site for ethanol...
  9. The Role of the Amygdala in Anesthetic-Induced Amnesia
    MICHAEL ALKIRE; Fiscal Year: 2003
    ..learning in rats, that the basolateral amygdala (BL) is critically nvolved with mediating the amnesic effects of propofol general anesthesia. Propofol does not produce amnesia if the BL is lesioned...
  10. The Role of the Amygdala in Anesthetic-Induced Amnesia
    MICHAEL ALKIRE; Fiscal Year: 2006
    ..learning in rats, that the basolateral amygdala (BL) is critically nvolved with mediating the amnesic effects of propofol general anesthesia. Propofol does not produce amnesia if the BL is lesioned...
  11. Isoflurane: Identification of Key New Targets
    Aaron P Fox; Fiscal Year: 2010
    ..Etomidate and propofol also inhibited the release machinery in PC12 cells, suggesting that inhibition of neurotransmitter release may be ..
  12. Isoflurane: Identification of Key New Targets
    Aaron Fox; Fiscal Year: 2009
    ..Etomidate and propofol also inhibited the release machinery in PC12 cells, suggesting that inhibition of neurotransmitter release may be ..
  13. Mechanisms of anesthetic effects on tachykinin induced airway tone
    Charles W Emala; Fiscal Year: 2010
    ..b>Propofol is known to allosterically enhance the activity of GABA at GABAA receptors in the brain and is recognized as the ..
  14. Mechanisms of anesthetic effects on tachykinin induced airway tone
    Charles Emala; Fiscal Year: 2007
    ..b>Propofol is known to allosterically enhance the activity of GABA at GABAA receptors in the brain and is recognized as the ..
  15. Propofol Interactions with GABA-A Receptors
    MYLES AKABAS; Fiscal Year: 2007
    ..The long term goal of this project is to elucidate the molecular bases of general anesthesia. Propofol, a widely used intravenous general anesthetic, is the major focus of this project...
  16. Propofol Interactions with GABA-A Receptors
    MYLES AKABAS; Fiscal Year: 2009
    ..The long term goal of this project is to elucidate the molecular bases of general anesthesia. Propofol, a widely used intravenous general anesthetic, is the major focus of this project...
  17. Fluorinated Nanocarriers for the Delivery of Anesthetics and Hydrophobic Drugs
    Sandro Mecozzi; Fiscal Year: 2010
    ..to more rapidly induce anesthesia than is possible using inhalation methods, and a more rapid awakening than even propofol produces...
  18. Fluorinated Nanocarriers for the Delivery of Anesthetics and Hydrophobic Drugs
    Sandro Mecozzi; Fiscal Year: 2007
    ..to more rapidly induce anesthesia than is possible using inhalation methods, and a more rapid awakening than even propofol produces...
  19. Propofol and Protein Kinase C: Molecular Interactions in Cardiomyocytes
    DEREK DAMRON; Fiscal Year: 2007
    ..Our primary goal is to identify the cellular signaling pathways by which the intravenous anesthetic, propofol, acts as a ligand to activate PKCe, and to delineate the molecular mechanism by which interaction and activation ..
  20. CNS TARGETS OF PROPOFOL'S HYPNOTIC AND MEMORY EFFECTS
    ROBERT VESELIS; Fiscal Year: 2003
    ..We have shown that one such drug, propofol, has memory effects independent of sedation during behavioral testing...
  21. BRAIN AND SPINAL CORD CONTRIBUTIONS TO ANESTHETIC ACTION
    JOSEPH ANTOGNINI; Fiscal Year: 2005
    ..In the past grant cycle we determined that isoflurane and propofol action in the spinal cord depressed the ascending transmission of nociceptive impulses to the brain...
  22. SITES OF ACTION OF INHALATIONAL ANESTHETICS ON HPV
    James Baumgardner; Fiscal Year: 2001
    ..The proposed studies will investigate the quantitative effects of inhalational and injectable (Propofol) general anesthetics on each step of this triphasic response...
  23. THE ROLE OF EPSILON SUBUNIT IN GABAA RECEPTOR FUNCTION
    TIM HALES; Fiscal Year: 2003
    ..Human homomeric and heteromeric 5-HT3 receptors are modulated by the intravenous anesthetic propofol which is reported to have anti-emetic properties.
  24. Crosby_Gregory_Mechanisms of Post-Anesthetic CNS Dysfunction in Aging
    Gregory Crosby; Fiscal Year: 2010
    ..on dendritic spine morphogenesis, synaptogenesis, and neurogenesis to test the hypotheses that isoflurane but not propofol 1. causes sustained disruption of mechanisms underlying spine and synapse formation;and 2...
  25. Crosby_Gregory_Mechanisms of Post-Anesthetic CNS Dysfunction in Aging
    Gregory Crosby; Fiscal Year: 2009
    ..on dendritic spine morphogenesis, synaptogenesis, and neurogenesis to test the hypotheses that isoflurane but not propofol 1. causes sustained disruption of mechanisms underlying spine and synapse formation; and 2...
  26. Crosby_Gregory_Mechanisms of Post-Anesthetic CNS Dysfunction in Aging
    Gregory Crosby; Fiscal Year: 2009
    ..on dendritic spine morphogenesis, synaptogenesis, and neurogenesis to test the hypotheses that isoflurane but not propofol 1. causes sustained disruption of mechanisms underlying spine and synapse formation; and 2...
  27. Propofol and Protein Kinase C: Molecular Interactions in Cardiomyocytes
    DEREK DAMRON; Fiscal Year: 2009
    ..Our primary goal is to identify the cellular signaling pathways by which the intravenous anesthetic, propofol, acts as a ligand to activate PKCe, and to delineate the molecular mechanism by which interaction and activation ..