Genomes and Genes
Summary: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
Publications303 found, 100 shown here
- Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trialsColin Baigent
CTSU, Oxford University, Oxford, UK
Lancet 373:1849-60. 2009Low-dose aspirin is of definite and substantial net benefit for many people who already have occlusive vascular disease. We have assessed the benefits and risks in primary prevention.
- Clopidogrel with or without omeprazole in coronary artery diseaseDeepak L Bhatt
Veterans AffairsBoston Healthcare System, Brigham and Women s Hospital, Boston, MA 02132, USA
N Engl J Med 363:1909-17. 2010..Recently, concerns have been raised about the potential for PPIs to blunt the efficacy of clopidogrel...
- Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trialS Connolly
Health Research Institute, Hamilton, ON, Canada
Lancet 367:1903-12. 2006..However, long-term monitoring is necessary and many patients cannot achieve optimum anticoagulation. We assessed whether clopidogrel plus aspirin was non-inferior to oral anticoagulation therapy for prevention of vascular events.
- Aspirin for primary prevention of cardiovascular events in people with diabetes: meta-analysis of randomised controlled trialsGiorgia De Berardis
Department of Clinical Pharmacology and Epidemiology, Consorzio Mario Negri Sud, Via Nazionale 8 A, 66030 S Maria Imbaro, Italy
BMJ 339:b4531. 2009To evaluate the benefits and harms of low dose aspirin in people with diabetes and no cardiovascular disease.
- Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trialsPeter M Rothwell
Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, Oxford, UK
Lancet 377:31-41. 2011Treatment with daily aspirin for 5 years or longer reduces subsequent risk of colorectal cancer...
- Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statementJack Cuzick
Cancer Research UK Centre for Epidemiology, Mathematics, and Statistics, Queen Mary University of London, London UK
Lancet Oncol 10:501-7. 2009Evidence clearly shows a chemopreventive effect for aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) on colorectal cancer and probably other cancer types; however, data on the risk-benefit profile for cancer prevention ..
- Low-dose aspirin for primary prevention of atherosclerotic events in patients with type 2 diabetes: a randomized controlled trialHisao Ogawa
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto City, 860 8556, Japan
JAMA 300:2134-41. 2008Previous trials have investigated the effects of low-dose aspirin on primary prevention of cardiovascular events, but not in patients with type 2 diabetes.
- Stroke with intermittent atrial fibrillation: incidence and predictors during aspirin therapy. Stroke Prevention in Atrial Fibrillation InvestigatorsR G Hart
Department of Medicine, University of Texas Health Science Center, San Antonio 78284, USA
J Am Coll Cardiol 35:183-7. 2000..This study was performed to characterize the risk of stroke in elderly patients with recurrent intermittent atrial fibrillation (AF)...
- EAACI/GA2LEN guideline: aspirin provocation tests for diagnosis of aspirin hypersensitivityE Nizankowska Mogilnicka
Department of Medicine, Jagiellonian University School of Medicine, Krakow, Poland
Allergy 62:1111-8. 2007b>Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most common causes of adverse drug reactions. Majority of them are of the hypersensitivity type...
- Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trialsPeter M Rothwell
Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, Oxford, UK
Lancet 376:1741-50. 2010High-dose aspirin (≥500 mg daily) reduces long-term incidence of colorectal cancer, but adverse effects might limit its potential for long-term prevention. The long-term effectiveness of lower doses (75-300 mg daily) is unknown...
- Aspirin "resistance" and risk of cardiovascular morbidity: systematic review and meta-analysisGeorge Krasopoulos
University Health Network, Division of Cardiovascular Surgery, Toronto General Hospital
BMJ 336:195-8. 2008To determine if there is a relation between aspirin "resistance" and clinical outcomes in patients with cardiovascular disease.
- Interindividual variability in the response to oral antiplatelet drugs: a position paper of the Working Group on antiplatelet drugs resistance appointed by the Section of Cardiovascular Interventions of the Polish Cardiac Society, endorsed by the Working Wiktor Kuliczkowski
3rd Department of Cardiology, Silesian Center for Heart Diseases, Zabrze, Poland
Eur Heart J 30:426-35. 2009..The efficacy of acetylsalicylic acid (ASA, aspirin) and clopidogrel in decreasing the risk of adverse events in coronary heart disease patients has been well ..
- Platelet function profiles in patients with type 2 diabetes and coronary artery disease on combined aspirin and clopidogrel treatmentDominick J Angiolillo
Division of Cardiology, University of Florida, Shands Jacksonville, 655 West 8th St, Jacksonville, FL 32209, USA
Diabetes 54:2430-5. 2005To assess platelet function profiles in diabetic and nondiabetic patients on aspirin and clopidogrel therapy, two patient populations were included to investigate the 1) acute effects of a 300-mg clopidogrel loading dose (group 1, n = 52)..
- Randomized double-blind assessment of the ONSET and OFFSET of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease: the ONSET/OFFSET studyPaul A Gurbel
Sinai Center for Thrombosis Research, Cardiac Catheterization Laboratory, 2401 W Belvedere Ave, Baltimore, MD 21215, USA
Circulation 120:2577-85. 2009..This is the first study to compare the onset and offset of platelet inhibition (IPA) with ticagrelor using the PLATO (PLATelet inhibition and patient Outcomes) trial loading dose (180 mg) with a high loading dose (600 mg) of clopidogrel...
- Continuation of low-dose aspirin therapy in peptic ulcer bleeding: a randomized trialJoseph J Y Sung
Institute of Digestive Disease, Chinese University of Hong Kong, Sha Tin, New Territories, Hong Kong
Ann Intern Med 152:1-9. 2010It is uncertain whether aspirin therapy should be continued after endoscopic hemostatic therapy in patients who develop peptic ulcer bleeding while receiving low-dose aspirin.
- Prasugrel versus clopidogrel in patients with acute coronary syndromesStephen D Wiviott
Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
N Engl J Med 357:2001-15. 2007Dual-antiplatelet therapy with aspirin and a thienopyridine is a cornerstone of treatment to prevent thrombotic complications of acute coronary syndromes and percutaneous coronary intervention.
- Oral anticoagulants vs aspirin in nonvalvular atrial fibrillation: an individual patient meta-analysisCarl van Walraven
Clinical Epidemiology Unit, Ottawa Health Research Institute, F 6, Ottawa Hospital, Civic Campus, 1053 Carling Ave, Ottawa, Ontario, Canada K1Y 4E9
JAMA 288:2441-8. 2002..Patients with nonvalvular atrial fibrillation (AF) have an increased risk of stroke and other vascular events...
- Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): a randomised controlled trialJonathan Mant
Primary Care Clinical Sciences, University of Birmingham, Birmingham, UK
Lancet 370:493-503. 2007..We assessed whether warfarin reduced risk of major stroke, arterial embolism, or other intracranial haemorrhage compared with aspirin in elderly patients.
- Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signalsCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Exp Med 196:1025-37. 2002b>Aspirin (ASA) is unique among current therapies because it acetylates cyclooxygenase (COX)-2 enabling the biosynthesis of R-containing precursors of endogenous antiinflammatory mediators...
- Aspirin sensitizes cancer cells to TRAIL-induced apoptosis by reducing survivin levelsMeiling Lu
Cell Death Regulation Laboratory, Department of Medicine and Cell and Molecular Biology, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
Clin Cancer Res 14:3168-76. 2008..We examined whether the nonsteroidal anti-inflammatory drug aspirin sensitized cancer cells to TRAIL agonists in vitro and in vivo and investigated the underlying mechanism.
- Aspirin intake and survival after breast cancerMichelle D Holmes
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Clin Oncol 28:1467-72. 2010Animal and in vitro studies suggest that aspirin may inhibit breast cancer metastasis. We studied whether aspirin use among women with breast cancer decreased their risk of death from breast cancer.
- Effects of low-dose aspirin on acute inflammatory responses in humansThea Morris
Division of Medicine, University College London, Centre for Clinical Pharmacology and Therapeutics, London, United Kingdom
J Immunol 183:2089-96. 2009b>Aspirin is a unique nonsteroidal anti-inflammatory drug; at high doses (aspirin(high), 1g), it is anti-inflammatory stemming from the inhibition of cyclooxygenase and proinflammatory signaling pathways including NF-kappaB, but is ..
- Association of PTGER gene family polymorphisms with aspirin intolerant asthma in Korean asthmaticsByung Lae Park
Department of Life Science, Sogang University, Seoul, Korea
BMB Rep 43:445-9. 2010b>Aspirin-intolerant asthma (AIA) is characterized by severe asthmatic attack after ingestion of aspirin and/or non-steroidal anti-inflammatory drugs...
- Risk of bleeding with single, dual, or triple therapy with warfarin, aspirin, and clopidogrel in patients with atrial fibrillationMorten L Hansen
Department of Cardiology, Copenhagen University Hospital Gentofte, Niels Andersens Vej 65 2900, Hellerup, Copenhagen, Denmark
Arch Intern Med 170:1433-41. 2010..Patients with atrial fibrillation (AF) often require anticoagulation and platelet inhibition, but data are limited on the bleeding risk of combination therapy...
- Effect of single nucleotide polymorphisms within the interleukin-4 promoter on aspirin intolerance in asthmatics and interleukin-4 promoter activityByung Soo Kim
Division of Molecular and Life Sciences, College of Science and Technology, Hanyang University, Sangrok Ku, Ansan, Gyeonggi Do, Korea
Pharmacogenet Genomics 20:748-58. 2010b>Aspirin affects interleukin-4 (IL-4) synthesis; however, the genetic role of IL-4 has not been evaluated in asthmatics with aspirin hypersensitivity...
- Prevention of preeclampsia and intrauterine growth restriction with aspirin started in early pregnancy: a meta-analysisEmmanuel Bujold
Department of Obstetrics and Gynecology, Faculty of Medicine, Laval University, Quebec, Canada
Obstet Gynecol 116:402-14. 2010To estimate the effect of low-dose aspirin started in early pregnancy on the incidence of preeclampsia and intrauterine growth restriction (IUGR).
- Clinical and pathologic perspectives on aspirin sensitivity and asthmaDonald D Stevenson
Division of Allergy, Asthma and Immunology and the Department of Medicine, Scripps Clinic and the Scripps Research Institute, La Jolla, USA
J Allergy Clin Immunol 118:773-86; quiz 787-8. 2006b>Aspirin and other nonsteroidal anti-inflammatory drugs that inhibit COX-1 induce unique nonallergic reactions, consisting of attacks of rhinitis and asthma...
- Posttreatment with aspirin-triggered lipoxin A4 analog attenuates lipopolysaccharide-induced acute lung injury in mice: the role of heme oxygenase-1Sheng wei Jin
Department of Anesthesiology, Second Affiliated Hospital, Wenzhou Medical College, Wenzhou, China
Anesth Analg 104:369-77. 2007..We hypothesized that posttreatment with 15-epi-16-parafluoro-phenoxy lipoxin A4 (ATL) could attenuate lipopolysaccharide (LPS)-induced acute lung injury in mice...
- Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issuesMichael J Thun
Department of Epidemiology and Surveillance Research, American Cancer Society, National Home Office, Atlanta, GA 30329 4251, USA
J Natl Cancer Inst 94:252-66. 2002..Finally, we suggest research opportunities that may help to accelerate the future clinical application of NSAIDs for cancer prevention or treatment...
- Aspirin for prevention of cardiovascular events in a general population screened for a low ankle brachial index: a randomized controlled trialF Gerald R Fowkes
Centre for Population Health Sciences, University of Edinburgh, Scotland
JAMA 303:841-8. 2010..Screening for a low ABI can identify an asymptomatic higher risk group potentially amenable to preventive treatments...
- Prevalence of asthma, aspirin intolerance, nasal polyposis and chronic obstructive pulmonary disease in a population-based studyJ Hedman
Department of Respiratory Medicine, Tampere University Hospital, Finland
Int J Epidemiol 28:717-22. 1999..The prevalence and relation to asthma of aspirin intolerance, nasal polyposis, allergic rhinitis and smoking habits were also examined.
- Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependentFabiana S Machado
Department of Immunology, Duke University Medical Center, Durham, North Carolina 27705, USA
Nat Med 12:330-4. 2006Control of inflammation is crucial to prevent damage to the host during infection. Lipoxins and aspirin-triggered lipoxins are crucial modulators of proinflammatory responses; however, their intracellular mechanisms have not been ..
- Aspirin and extended-release dipyridamole versus clopidogrel for recurrent strokeRalph L Sacco
Miller School of Medicine, University of Miami, Miami, USA
N Engl J Med 359:1238-51. 2008Recurrent stroke is a frequent, disabling event after ischemic stroke. This study compared the efficacy and safety of two antiplatelet regimens--aspirin plus extended-release dipyridamole (ASA-ERDP) versus clopidogrel.
- Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: a double-blind comparison to clopidogrel with aspirinSteen Husted
Department of Medicine and Cardiology, Arhus University Hospital, Denmark
Eur Heart J 27:1038-47. 2006..This double-blind, parallel-group study was conducted to assess the pharmacodynamics, pharmacokinetics, and safety of AZD6140, the first oral, reversible adenosine diphosphate (ADP) receptor antagonist...
- Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosisMarc I Chimowitz
Department of Neurology, School of Medicine, Emory University, Atlanta, USA
N Engl J Med 352:1305-16. 2005Atherosclerotic intracranial arterial stenosis is an important cause of stroke. Warfarin is commonly used in preference to aspirin for this disorder, but these therapies have not been compared in a randomized trial.
- A randomized study assessing the impact of cilostazol on platelet function profiles in patients with diabetes mellitus and coronary artery disease on dual antiplatelet therapy: results of the OPTIMUS-2 studyDominick J Angiolillo
Division of Cardiology, University of Florida College of Medicine at Shands Jacksonville, Jacksonville, FL 32209, USA
Eur Heart J 29:2202-11. 2008..The aim of this pilot study was to assess the functional impact of cilostazol in T2DM patients on standard aspirin and clopidogrel treatment.
- Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseasesT E Van Dyke
Department of Periodontology and Oral Biology, Boston University, Goldman School of Dental Medicine, 100 East Newton Street, Boston, MA 02118, USA
J Dent Res 82:82-90. 2003....
- Leukotriene-receptor expression on nasal mucosal inflammatory cells in aspirin-sensitive rhinosinusitisAna R Sousa
Guy's, King's and St. Thomas' School of Medicine, London, United Kingdom
N Engl J Med 347:1493-9. 2002BACKGROUND: Patients with asthma who have aspirin sensitivity have greater cysteinyl leukotriene production and greater airway hyperresponsiveness to the effects of inhaled cysteinyl leukotrienes than their aspirin-tolerant counterparts...
- Aspirin dose for the prevention of cardiovascular disease: a systematic reviewCharles L Campbell
Gill Heart Institute, University of Kentucky, Lexington, USA
JAMA 297:2018-24. 2007More than 50 million US adults take aspirin regularly for long-term prevention of cardiovascular disease, typically either 81 mg/d or 325 mg/d. Controversy remains regarding the most appropriate long-term daily dose.
- Selecting patients with atrial fibrillation for anticoagulation: stroke risk stratification in patients taking aspirinBrian F Gage
Division of General Medical Sciences, Washington University School of Medicine Campus Box 8005, 660 S Euclid Ave, St Louis, MO 63110, USA
Circulation 110:2287-92. 2004..Although adjusted-dose warfarin is superior to aspirin for reducing stroke in AF, the absolute risk reduction of warfarin depends on the stroke rate with aspirin...
- Low-dose aspirin for prevention of stroke in low-risk patients with atrial fibrillation: Japan Atrial Fibrillation Stroke TrialHiroshi Sato
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan
Stroke 37:447-51. 2006..We examined the efficacy and safety of aspirin therapy in Japanese patients with NVAF in a prospective randomized multicenter trial.
- Low molecular weight heparin and aspirin for recurrent pregnancy loss: results from the randomized, controlled HepASA TrialCarl A Laskin
University of Toronto and LifeQuest Centre for Reproductive Medicine, Toronto, Canada
J Rheumatol 36:279-87. 2009..loss (RPL) and either autoantibodies or a coagulation abnormality, treated with low molecular weight heparin plus aspirin (LMWH/ASA) or ASA alone, and to place our results in context with other randomized clinical trials (RCT) with ..
- Interaction of inflammation, thrombosis, aspirin and enoxaparin in CNS experimental antiphospholipid syndromeDavid Tanne
Department of Neurology, Sheba Medical Center, Tel Hashomer, Israel Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, Israel
Neurobiol Dis 30:56-64. 2008..eAPS) or adjuvant (controls) and treated daily from 1 month after immunization with either sham injections, aspirin (1.2 mg/kg) or enoxaparin (1 mg/kg) for 3 months...
- Aspirin for the primary prevention of cardiovascular events in women and men: a sex-specific meta-analysis of randomized controlled trialsJeffrey S Berger
Department of Cardiovascular Medicine, Duke University, Durham, NC, USA
JAMA 295:306-13. 2006CONTEXT: Aspirin therapy reduces the risk of cardiovascular disease in adults who are at increased risk. However, it is unclear if women derive the same benefit as men...
- Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndromeJohn Burn
Institute of Human Genetics, Newcastle University, International Centre for Life, Central Pkwy, Newcastle upon Tyne NE1 3BZ, United Kingdom
N Engl J Med 359:2567-78. 2008Observational and epidemiologic data indicate that the use of aspirin reduces the risk of colorectal neoplasia; however, the effects of aspirin in the Lynch syndrome (hereditary nonpolyposis colon cancer) are not known...
- Platelet inhibition by aspirin 81 and 325 mg/day in men versus women without clinically apparent cardiovascular diseaseRehan Qayyum
Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Cardiol 101:1359-63. 2008Compared with men, women have greater platelet aggregation before and after low-dose aspirin. It is not known whether high-dose aspirin therapy brings residual platelet aggregation in women closer to that in men...
- Aspirin and recurrent intracerebral hemorrhage in cerebral amyloid angiopathyA Biffi
Department of Neurology and Hemorrhagic Stroke Research Program, Massachusetts General Hospital Stroke Research Center, Harvard Medical School, 175 Cambridge Street, Suite 300, Boston, MA 02114, USA
Neurology 75:693-8. 2010..To identify and compare clinical and neuroimaging predictors of primary lobar intracerebral hemorrhage (ICH) recurrence, assessing their relative contributions to recurrent ICH...
- Incidence and clinical impact of dual nonresponsiveness to aspirin and clopidogrel in patients with drug-eluting stentsAnna Maria Gori
Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
J Am Coll Cardiol 52:734-9. 2008This study sought to determine the incidence of aspirin nonresponsiveness in addition to clopidogrel nonresponsiveness and whether this association identifies patients at an increased risk of drug-eluting stent (DES) thrombosis.
- Duration of dual antiplatelet therapy after implantation of drug-eluting stentsSeung Jung Park
Department of Cardiology, Center for Medical Research and Information, University of Ulsan College of Medicine, Seoul, South Korea
N Engl J Med 362:1374-82. 2010..The potential benefits and risks of the use of dual antiplatelet therapy beyond a 12-month period in patients receiving drug-eluting stents have not been clearly established...
- Effect of aspirin and NSAIDs on risk and survival from colorectal cancerFarhat V N Din
Colon Cancer Genetics Group and Academic Coloproctology, Institute of Genetics and Molecular Medicine, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK
Gut 59:1670-9. 2010Previous studies have shown that aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) lower colorectal cancer (CRC) risk. However, the lowest effective NSAID dose, treatment duration, and effects on survival are not defined...
- Effect of platelet turnover on whole blood platelet aggregation in patients with coronary artery diseaseE L Grove
Departments ofCardiology Clinical Biochemistry, Aarhus University Hospital, Skejby, Aarhus, Denmark
J Thromb Haemost 9:185-91. 2011Previous studies have demonstrated considerable variation in the antiplatelet effect of aspirin.
- The effect of aspirin desensitization on novel biomarkers in aspirin-exacerbated respiratory diseasesRohit K Katial
Division of Allergy and Immunology, National Jewish Health, Denver, CO 80206, USA
J Allergy Clin Immunol 126:738-44. 2010Patients with aspirin-exacerbated respiratory disease have been shown to benefit clinically from aspirin desensitization followed by chronic high-dose aspirin therapy. However, the mechanism of this phenomenon is still unclear.
- Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statinsMatthew Spite
Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Circ Res 107:1170-84. 2010..Here, we overview and update the biosynthesis and actions of proresolving lipid mediators, highlighting their diverse protective roles relevant to vascular systems and their relation to aspirin and statin therapies.
- Association of SLC6A12 variants with aspirin-intolerant asthma in a Korean populationCharisse Flerida A Pasaje
Department of Life Science, Sogang University, Seoul, 121 742, Republic of Korea
Ann Hum Genet 74:326-34. 2010b>Aspirin-intolerant asthma (AIA) occurs from asthma exacerbation after exposure to aspirin. However, the underlying mechanisms of AIA occurrence are still unclear...
- Effect of in vitro aspirin stimulation on basophils in patients with aspirin-exacerbated respiratory diseaseG E Celik
Ankara University School of Medicine, Division of Allergy, Ankara, Turkey
Clin Exp Allergy 39:1522-31. 2009Basophil activation has been implicated in the pathogenesis of aspirin-exacerbated respiratory disease (AERD)...
- Current use of aspirin and antithrombotic agents in the United States among outpatients with atherothrombotic disease (from the REduction of Atherothrombosis for Continued Health [REACH] Registry)Christopher P Cannon
TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Am J Cardiol 105:445-52. 2010Despite its proven efficacy, low cost, and wide availability, aspirin remains underused. We examined current aspirin use and determined factors that influence its use among outpatients in the United States (US)...
- Effect of statin drugs and aspirin on progression in open-angle glaucoma suspects using confocal scanning laser ophthalmoscopyDawn K De Castro
Department of Ophthalmology, University of California at San Francisco, San Francisco, California 94143 0730, USA
Clin Experiment Ophthalmol 35:506-13. 2007To determine the effect of statins and aspirin on the rate of progression of optic nerve parameters in open-angle glaucoma (OAG) suspects, as defined by confocal scanning laser ophthalmoscopy (CSLO).
- Aspirin induces gastric epithelial barrier dysfunction by activating p38 MAPK via claudin-7Tadayuki Oshima
Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Am J Physiol Cell Physiol 295:C800-6. 2008..However, the mechanism by which aspirin affects the function of gastric epithelial tight junctions is unknown...
- First analysis of the relation between CYP2C19 genotype and pharmacodynamics in patients treated with ticagrelor versus clopidogrel: the ONSET/OFFSET and RESPOND genotype studiesUdaya S Tantry
Sinai Center for Thrombosis Research, Cardiac Catheterization Laboratory, 2401 W Belvedere Ave, Baltimore, MD 21215, USA
Circ Cardiovasc Genet 3:556-66. 2010..The influence of cytochrome P450 (CYP) 2C19 genotype on platelet function in patients treated with ticagrelor versus clopidogrel is unknown...
- A randomised controlled trial of warfarin versus aspirin for stroke prevention in octogenarians with atrial fibrillation (WASPO)Amar Rash
Northern General Hospital, Medicine for the Elderly, Sheffield, UK
Age Ageing 36:151-6. 2007..Although trials demonstrate reductions in stroke with warfarin, audit data show that it is still underused. However, anti-coagulation in the very elderly is not without risk...
- The flow-cytometric determination of basophil activation induced by aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) is useful for in vitro diagnosis of the NSAID hypersensitivity syndromeP Gamboa
Allergy Unit, Hospital Basurto, Bilbao, Spain
Clin Exp Allergy 34:1448-57. 2004..Isolated buffy coat leukocytes were stimulated in vitro with aspirin, paracetamol, metamizol, diclofenac, and naproxen...
- Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivationYee Ping Sun
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 282:9323-34. 2007..stereochemistry of the conjugated double bonds and chirality of alcohols present in resolvin D1 (RvD1) and its aspirin-triggered 17R epimer (AT-RvD1) with compounds prepared by total organic synthesis...
- Unraveling the lethal synergism between Trypanosoma cruzi infection and LPS: a role for increased macrophage reactivityClaudia N Paiva
Departamento de Imunologia, Instituto de Microbiologia Prof Paulo de Goes, UFRJ, Rio de Janeiro, Brasil
Eur J Immunol 37:1355-64. 2007..Our results point to independent MIF and TNF/TNF-R1 lethal pathways and suggest a role for hyperactivated macrophages in T. cruzi-sensitized LPS-induced shock...
- Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NF-kappa B and AP-1 activation, and IL-8 gene expression in human leukocytesLevente Jozsef
Research Center, Maisonneuve Rosemont Hospital and Department of Medicine, University of Montreal, Montreal, QC, Canada H1T 2M4
Proc Natl Acad Sci U S A 99:13266-71. 2002Lipoxin A(4) (LXA(4)) and aspirin-triggered 15-epi-LXA(4) (ATL) are emerging as endogenous braking signals for neutrophil-mediated tissue injury...
- Role of reactive oxygen metabolites in aspirin-induced gastric damage in humans: gastroprotection by vitamin CT Pohle
Department of Medicine B, University of Munster, Munster, Germany
Aliment Pharmacol Ther 15:677-87. 2001The roles of active oxygen metabolites and anti-oxidative defenses in aspirin (ASA)-induced gastric damage have been little studied.
- Variations between countries in outcome after stroke in the International Stroke Trial (IST)N U Weir
Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK
Stroke 32:1370-7. 2001..We used the frequency of prerandomization head CT scan and prescription of aspirin at discharge to indicate quality of care...
- Nonsteroidal anti-inflammatory drugs and risk of Parkinson's diseaseThanh G Ton
Department of Epidemiology, University of Washington, Seattle, Washington 98195, USA
Mov Disord 21:964-9. 2006..animal studies suggests a possible protective role of nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin. We investigated the risk of PD associated with use of aspirin and nonaspirin NSAIDs in a population-based case-..
- Insulin therapy is associated with platelet dysfunction in patients with type 2 diabetes mellitus on dual oral antiplatelet treatmentDominick J Angiolillo
Division of Cardiology, University of Florida, Shands Jacksonville, Jacksonville, Florida 32209, USA
J Am Coll Cardiol 48:298-304. 2006..This study sought to assess the influence of type 2 diabetes mellitus (T2DM) and the impact of hypoglycemic treatment (insulin vs. noninsulin) on platelet function profiles in patients treated with dual oral antiplatelet therapy...
- Indications for early aspirin use in acute ischemic stroke : A combined analysis of 40 000 randomized patients from the chinese acute stroke trial and the international stroke trial. On behalf of the CAST and IST collaborative groupsZ M Chen
Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford, UK
Stroke 31:1240-9. 2000Long-term daily aspirin is of benefit in the years after ischemic stroke, and 2 large randomized trials (the Chinese Acute Stroke Trial [CAST] and the International Stroke Trial [IST]), with 20 000 patients in each, have shown that ..
- Increased basal platelet activity, plasma adiponectin levels, and diabetes mellitus are associated with poor platelet responsiveness to in vitro effect of aspirinShinichi Takahashi
The Keio Daiichi Project on Genetics of Thrombosis, Keio University, Tokyo, Japan
Thromb Res 119:517-24. 2007b>Aspirin is one of the most effective antiplatelet agents and is now commonly used to prevent vascular events. In some patients, however, recurrent vascular events have been demonstrated despite aspirin therapy...
- Cilostazol for prevention of secondary stroke (CSPS 2): an aspirin-controlled, double-blind, randomised non-inferiority trialYukito Shinohara
Federation of National Public Service Personnel Mutual Aid Associations Tachikawa Hospital, Tachikawa, Tokyo, Japan
Lancet Neurol 9:959-68. 2010..designed the second Cilostazol Stroke Prevention Study (CSPS 2) to establish non-inferiority of cilostazol versus aspirin for prevention of stroke, and to compare the efficacy and safety of cilostazol and aspirin in patients with non-..
- PGE suppresses excessive anti-IgE induced cysteinyl leucotrienes production in mast cells of patients with aspirin exacerbated respiratory diseaseX S Wang
Department of Pharmacology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
Allergy 62:620-7. 2007b>Aspirin causes bronchospasm in patients with aspirin exacerbated respiratory disease (AERD). The contribution of mast cells to the increased cysteinyl-leucotrienes (cys-LTs) detected in AERD patients is however not defined.
- Aspirin attenuates gentamicin ototoxicity: from the laboratory to the clinicYang Chen
Department of Otolaryngology, Xijing Hospital, Fourth Military Medical University, Xi an, PR China
Hear Res 226:178-82. 2007..H., Qiu, J.-H., Schacht, J., 2006. Aspirin attenuates gentamicin-induced hearing loss. New Engl. J. Med. 354, 1856-1857)...
- Incidence of dyspnea and assessment of cardiac and pulmonary function in patients with stable coronary artery disease receiving ticagrelor, clopidogrel, or placebo in the ONSET/OFFSET studyRobert F Storey
Department of Cardiovascular Science, University of Sheffield, and NIHR Cardiovascular Biomedical Research Unit, Sheffield, United Kingdom
J Am Coll Cardiol 56:185-93. 2010..Double-Blind, Double-Dummy Parallel Group Study of the Onset and Offset of Antiplatelet Effects of AZD6140 Compared With Clopidogrel and Placebo With Aspirin as Background Therapy in Patients With Stable Coronary Artery Disease) study.
- Effect of fucoidan on aspirin-induced stomach ulceration in ratsJong Il Choi
Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup 580 185, Republic of Korea
Chem Biol Interact 183:249-54. 2010In this study, the effects of fucoidan on aspirin-induced ulcers in rats were evaluated: both biochemical and immunological parameters were taken into consideration...
- Genome-wide methylation profile of nasal polyps: relation to aspirin hypersensitivity in asthmaticsH S Cheong
Department of Genetic Epidemiology, SNP Genetics, Inc, Gasan Dong, Geumcheon gu, Seoul, Korea
Allergy 66:637-44. 2011In addition to the dysregulation of arachidonic acid metabolism in aspirin-intolerant asthma (AIA), aspirin acetylsalicylic acid (ASA) exerts effects on inflammation and immunity; however, many of these effects are unknown.
- Nonsteroidal anti-inflammatory drugs and the incidence of Parkinson diseaseMiguel A Hernán
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Neurology 66:1097-9. 2006..93 (0.80 to 1.08) for nonaspirin NSAIDs, 1.29 (1.05 to 1.58) for aspirin, and 1.16 (1.00 to 1.35) for acetaminophen...
- High on-aspirin platelet reactivity as measured with aggregation-based, cyclooxygenase-1 inhibition sensitive platelet function tests is associated with the occurrence of atherothrombotic eventsN J Breet
Department of Cardiology, St Antonius Hospital, Nieuwegein, The Netherlands
J Thromb Haemost 8:2140-8. 2010High on-aspirin platelet reactivity (HAPR) is associated with atherothrombotic events following percutaneous coronary intervention (PCI)...
- Aspirin sensitivity and desensitization for asthma and sinusitisDonald D Stevenson
Scripps Clinic at Carmel Valley, San Diego, CA 92130, USA
Curr Allergy Asthma Rep 9:155-63. 2009NSAIDs-including aspirin (ASA)-that inhibit cyclooxygenase (COX)-1 induce nonallergic hypersensitivity reactions consisting of attacks of rhinitis and asthma...
- Platelet function and response to aspirin: gender-specific features and implications for female thrombotic risk and managementChristine S Zuern
Abteilung Kardiologie und Kreislauferkrankungen, Medizinische Klinik III, Universitaetsklinikum Tuebingen, Germany
Semin Thromb Hemost 35:295-306. 2009This article reviews gender-specific differences in platelet function and response to aspirin. In contrast with men, women under 65 years of age do not benefit from aspirin therapy in primary prevention of coronary artery disease...
- Intensifying platelet inhibition with tirofiban in poor responders to aspirin, clopidogrel, or both agents undergoing elective coronary intervention: results from the double-blind, prospective, randomized Tailoring Treatment with Tirofiban in Patients ShoMarco Valgimigli
Cardiovascular Institute, University of Ferrara, S Anna Hospital, Corso Giovecca 203, Ferrara, Italy
Circulation 119:3215-22. 2009Inhibition of platelet aggregation after aspirin or clopidogrel intake varies greatly among patients, and previous studies have suggested that poor response to oral antiplatelet agents may increase the risk of thrombotic events, ..
- Circadian variations of gastrointestinal mucosal damage detected with transnasal endoscopy in apparently healthy subjects treated with low-dose aspirin (ASA) for a short periodTakashi Kawai
Endoscopy Center, Tokyo Medical University Hospital, Tokyo 160 0023, Japan
J Atheroscler Thromb 16:155-63. 2009In this study, transnasal endoscopy was used to observe the time-course changes of gastrointestinal mucosa with low-dose aspirin (ASA), and the preventive effect of rebamipide was compared with placebo.
- Famotidine for the prevention of peptic ulcers and oesophagitis in patients taking low-dose aspirin (FAMOUS): a phase III, randomised, double-blind, placebo-controlled trialAli S Taha
Gastroenterology Unit, Crosshouse Hospital, University of Glasgow, Kilmarnock, UK
Lancet 374:119-25. 2009There are few therapeutic options for the prevention of gastrointestinal mucosal damage caused by low-dose aspirin. We therefore investigated the efficacy of famotidine, a well-tolerated histamine H(2)-receptor antagonist, in the ..
- Effect of intravenous tirofiban and aspirin in reducing short-term and long-term neurologic deficit in patients with ischemic stroke: a double-blind randomized trialG Torgano
Department of Emergency Medicine, Fondazione IRCCS Ospedale Maggiore Policlinico Mangiagalli e Regina Elena, Milano, Italy
Cerebrovasc Dis 29:275-81. 2010..5 h). After this time, the choice is limited to endovascular treatment and antiplatelet drugs, mainly aspirin (ASA), the efficacy of which in the acute phase of stroke has poorly been evaluated...
- Aspirin in cardiology--benefits and risksL Bjorklund
Pharmacy Program, Gothenburg University, Gothenburg, Sweden
Int J Clin Pract 63:468-77. 2009To review the current knowledge of the benefits and risks of long-term aspirin therapy for the prevention of cardiovascular disease.
- Low-dose aspirin therapy for cardiovascular prevention: quantification and consequences of poor compliance or discontinuationJohan Herlitz
Sahlgrenska University Hospital, Gothenburg, Sweden
Am J Cardiovasc Drugs 10:125-41. 2010Long-term therapy with low-dose aspirin (acetylsalicylic acid; ASA), 75-325 mg, is highly effective for the secondary prevention of cardiovascular (CV) events...
- APT102, a novel adpase, cooperates with aspirin to disrupt bone metastasis in miceOzge Uluçkan
Department of Medicine, Division of Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Cell Biochem 104:1311-23. 2008..the role of a novel soluble apyrase/ADPase, APT102, and an inhibitor of TXA(2) synthesis, acetylsalicylic acid (aspirin or ASA), in mouse models of experimental bone metastases...
- Arterial cardiovascular events, statins, low-dose aspirin and subsequent risk of venous thromboembolism: a population-based case-control studyH T Sørensen
Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus C, Denmark
J Thromb Haemost 7:521-8. 2009..There are similar confusions regarding the association of the use of aspirin and statins with venous thromboembolism.
- Small bowel enteropathy associated with chronic low-dose aspirin therapyWai K Leung
Institute of Digestive Disease, The Chinese University of Hong Kong and Department of Medicine and Therapeutics, Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, Hong Kong, China
Lancet 369:614. 2007
- Aspirin: promise and resistance in the new millenniumCarlo Patrono
Department of Pharmacology, Catholic University School of Medicine, Rome, Italy
Arterioscler Thromb Vasc Biol 28:s25-32. 2008Although conceived at the end of the 19th century, aspirin remains the gold standard of antiplatelet therapy...
- Role of aspirin in the primary prevention of cardiovascular disease in diabetes mellitus: a meta-analysisNaveed Younis
University Hospital South Manchester, Wythenshawe Hospital, Department of Diabetes and Endocrinology, Southmoor Road, Manchester M23 9LT, UK
Expert Opin Pharmacother 11:1459-66. 2010To evaluate the benefits of aspirin in people with diabetes mellitus for the primary prevention of cardiovascular disease.
- Aspirin resistance: does it exist and is it an important clinical problem?John Eikelboom
Thrombosis Service, Hamilton General Hospital
Clin Adv Hematol Oncol 4:268-70. 2006
- Current developments in anti-platelet therapyFlorian B Mayr
Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
Wien Med Wochenschr 156:472-80. 2006..Acetyl-salicylic acid (ASA, aspirin) is still the most widely used agent and considered as the prototype antiplatelet drug...
- Current practice of antithrombotic treatment in ischemic stroke: a survey among Hungarian neurologistsLśzló K Sztriha
Department of Neurology, Albert Szent Gyorgyi Clinical Center, University of Szeged, Szeged, Hungary
Ideggyogy Sz 61:148-54. 2008..However, the application of the trial results still remains uncertain in some clinical situations. We set out to evaluate the various aspects of antithrombotic treatment use among clinical practitioners...
- Does a coxib-associated thrombotic risk limit the clinical use of the compounds as analgesic, antiinflammatory drugs? Arguments againstArtur Aron Weber
Institut fur Pharmakologie und Klinische Pharmakologie, Universitatsklinikum Dusseldorf, Dusseldorf, Germany
Thromb Haemost 96:413-6. 2006..Several arguments support the concept, that COX-2 inhibitors remain a valuable therapeutic option at least for selected patients...
- Plasma levels of the growth arrest-specific gene 6 product (Gas6) and antiplatelet drug responsiveness in healthy subjectsL Burnier
J Thromb Haemost 4:2283-4. 2006
- [Even in 60-year-old atrial fibrillation is not uncommon. Advances in long-term treatment]Gerhard Steinbeck
Medizinische Klinik I,
MMW Fortschr Med 148:31. 2006
- Drug drug interactions between antithrombotic medications and the risk of gastrointestinal bleedingJoseph A Delaney
Division of Clinical Epidemiology, McGill University Health Centre, Montreal, Que
CMAJ 177:347-51. 2007..We assessed whether antithrombotic drug combinations increased the risk of such bleeding in a general practice population...
- Unveiling the inflammatory face of antiplatelet drugsG Davi
Center of Excellence on Aging, G d Annunzio University Foundation, Chieti, Italy
J Thromb Haemost 4:2137-9. 2006
- Upper GI risks of NSAIDs and antiplatelet agents: key issues for the cardiologistDavid A Johnson
Division of Gastroenterology, Eastern Virginia Medical School, Norfolk, Virginia, USA
Rev Cardiovasc Med 6:S15-22. 2005The use of antiplatelet/antithrombotic agents (eg, low-dose aspirin or clopidogrel) in primary or secondary intervention treatment strategies for cardiovascular disease is a common practice among cardiologists...
- The effect of platelet-altering medications on bleeding from minor oral surgery proceduresCorbin G Partridge
Department of Oral Surgery and Hospital Dentistry, Indiana University, Indianapolis, IN, USA
J Oral Maxillofac Surg 66:93-7. 2008..They were compared with patients who were not taking platelet-altering medicines to assess differences in extent of blood loss...
- Novel mechanisms by which aspirin might protect against atherosclerosisSampath Parthasarathy; Fiscal Year: 2010b>Aspirin ('acetylsalicylic acid') inhibits the formation of prostaglandins (PGs) that cause inflammation, swelling, pain and fever...
- A Clinical Trial of Aspirin and Simvastatin in Pulmonary Arterial HypertensionSteven Kawut; Fiscal Year: 2007..HMG-CoA reductase inhibitors (statins) and aspirin are very safe, highly-effective cardiovascular therapies used by millions of people...
- Aspirin and Simvastatin--Pulmonary Arterial HypertensionSteven Kawut; Fiscal Year: 2006..HMG-CoA reductase inhibitors (statins) and aspirin are very safe, highly-effective cardiovascular therapies used by millions of people...
- A Clinical Trial of Aspirin and Simvastatin in Pulmonary Arterial HypertensionSteven Kawut; Fiscal Year: 2009..HMG-CoA reductase inhibitors (statins) and aspirin are very safe, highly-effective cardiovascular therapies used by millions of people...
- Role of IRF3 and RXRa Crosstalk in Host Response to Viral InfectionsGenhong Cheng; Fiscal Year: 2010..metabolic diseases such as Reye's Syndrome, a hepatotoxicity disease that occurs when children are given aspirin in the context of a viral infection, or acetaminophen (APAP)-induced hepatotoxicity, which accounts for about ..
- Aspirin, Helicobacter Pylori, and Peptic Ulcer DiseaseEdward Lew; Fiscal Year: 2003b>Aspirin and other non-steroidal anti-inflammatory drugs are widely used to treat pain and inflammation, and at low doses, aspirin is also increasingly being used for cardiovascular prophylaxis...
- RANDOMIZED TRIALS OF VITAMIN SUPPLEMENTS AND EYE DISEASEWilliam Christen; Fiscal Year: 2002..The PHS is a randomized, double-blind, placebo-controlled trial of aspirin use in reducing cardiovascular disease, and beta-carotene in reducing cancer, among 22,071 male U.S...
- RANDOMIZED TRIALS OF VITAMIN SUPPLEMENTS AND EYE DISEASEWilliam Christen; Fiscal Year: 1993..The PHS is a randomized, double-blind, placebo-controlled trial of aspirin use in reducing cardiovascular disease, and beta-carotene in reducing cancer, among 22,071 male U.S...
- POLYMORPHISMS IN PG/COX PATHWAY AND COLORECTAL POLYPSCornelia Ulrich; Fiscal Year: 2003b>Aspirin and other non-steroidal inflammatory drugs (NSAIDs) reduce the recurrence of colorectal polyps among patients with familial adenomatous polyposis (FAP) and are associated with a lower risk of both adenoma and colorectal cancer...
- NO Releasing Aspirin and Colon Cancer ChemopreventionBasil Rigas; Fiscal Year: 2003..Current evidence suggests that they are much safer than traditional NSAIDs. Early studies indicate that an NO-aspirin (NO-ASA) derivative is much more effective than ASA in cultured cells and against colon preneoplastic lesions...
- NO Releasing Aspirin and Colon Cancer ChemopreventionBasil Rigas; Fiscal Year: 2005..Current evidence suggests that they are much safer than traditional NSAIDs. Early studies indicate that an NO-aspirin (NO-ASA) derivative is much more effective than ASA in cultured cells and against colon preneoplastic lesions...
- ANALGESIC USE AND THE RISK OF CHRONIC RENAL FAILUREGary Curhan; Fiscal Year: 2002..with consumption of large amounts of acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) but not aspirin. Since these analgesics are widely available and used, their association with renal dysfunction is particularly ..