aspirin

Summary

Summary: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)

Top Publications

  1. ncbi Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial
    S Connolly
    Health Research Institute, Hamilton, ON, Canada
    Lancet 367:1903-12. 2006
  2. pmc Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival
    Xiaoyun Liao
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 367:1596-606. 2012
  3. pmc Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials
    Colin Baigent
    CTSU, Oxford University, Oxford, UK
    Lancet 373:1849-60. 2009
  4. pmc Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 196:1025-37. 2002
  5. ncbi Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials
    Peter M Rothwell
    Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK
    Lancet 379:1602-12. 2012
  6. ncbi Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials
    Peter M Rothwell
    Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK
    Lancet 379:1591-601. 2012
  7. ncbi Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials
    Peter M Rothwell
    Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, Oxford, UK
    Lancet 376:1741-50. 2010
  8. ncbi Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials
    Peter M Rothwell
    Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, Oxford, UK
    Lancet 377:31-41. 2011
  9. ncbi Effect of aspirin on vascular and nonvascular outcomes: meta-analysis of randomized controlled trials
    Sreenivasa Rao Kondapally Seshasai
    St George s University of London, London, England
    Arch Intern Med 172:209-16. 2012
  10. ncbi Aspirin and cancer risk: a quantitative review to 2011
    C Bosetti
    Department of Epidemiology, Istituto di Ricerche Farmacologiche, Mario Negri, Milan, Italy
    Ann Oncol 23:1403-15. 2012

Detail Information

Publications369 found, 100 shown here

  1. ncbi Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial
    S Connolly
    Health Research Institute, Hamilton, ON, Canada
    Lancet 367:1903-12. 2006
    ..However, long-term monitoring is necessary and many patients cannot achieve optimum anticoagulation. We assessed whether clopidogrel plus aspirin was non-inferior to oral anticoagulation therapy for prevention of vascular events.
  2. pmc Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival
    Xiaoyun Liao
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 367:1596-606. 2012
    Regular use of aspirin after a diagnosis of colon cancer has been associated with a superior clinical outcome...
  3. pmc Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials
    Colin Baigent
    CTSU, Oxford University, Oxford, UK
    Lancet 373:1849-60. 2009
    Low-dose aspirin is of definite and substantial net benefit for many people who already have occlusive vascular disease. We have assessed the benefits and risks in primary prevention.
  4. pmc Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 196:1025-37. 2002
    b>Aspirin (ASA) is unique among current therapies because it acetylates cyclooxygenase (COX)-2 enabling the biosynthesis of R-containing precursors of endogenous antiinflammatory mediators...
  5. ncbi Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials
    Peter M Rothwell
    Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK
    Lancet 379:1602-12. 2012
    Daily aspirin reduces the long-term risk of death due to cancer...
  6. ncbi Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials
    Peter M Rothwell
    Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK
    Lancet 379:1591-601. 2012
    Daily aspirin reduces the long-term incidence of some adenocarcinomas, but effects on mortality due to some cancers appear after only a few years, suggesting that it might also reduce growth or metastasis...
  7. ncbi Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials
    Peter M Rothwell
    Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, Oxford, UK
    Lancet 376:1741-50. 2010
    High-dose aspirin (≥500 mg daily) reduces long-term incidence of colorectal cancer, but adverse effects might limit its potential for long-term prevention. The long-term effectiveness of lower doses (75-300 mg daily) is unknown...
  8. ncbi Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials
    Peter M Rothwell
    Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, Oxford, UK
    Lancet 377:31-41. 2011
    Treatment with daily aspirin for 5 years or longer reduces subsequent risk of colorectal cancer...
  9. ncbi Effect of aspirin on vascular and nonvascular outcomes: meta-analysis of randomized controlled trials
    Sreenivasa Rao Kondapally Seshasai
    St George s University of London, London, England
    Arch Intern Med 172:209-16. 2012
    The net benefit of aspirin in prevention of CVD and nonvascular events remains unclear. Our objective was to assess the impact (and safety) of aspirin on vascular and nonvascular outcomes in primary prevention.
  10. ncbi Aspirin and cancer risk: a quantitative review to 2011
    C Bosetti
    Department of Epidemiology, Istituto di Ricerche Farmacologiche, Mario Negri, Milan, Italy
    Ann Oncol 23:1403-15. 2012
    b>Aspirin has been associated to a reduced risk of colorectal and possibly of a few other common cancers.
  11. ncbi Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials
    Annemijn M Algra
    Stroke Prevention Research Unit, University Department of Clinical Neurology, University of Oxford, Oxford, UK
    Lancet Oncol 13:518-27. 2012
    Long-term follow-up of randomised trials of aspirin in prevention of vascular events showed that daily aspirin reduced the incidence of colorectal cancer and several other cancers and reduced metastasis...
  12. ncbi Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): a randomised controlled trial
    Jonathan Mant
    Primary Care Clinical Sciences, University of Birmingham, Birmingham, UK
    Lancet 370:493-503. 2007
    ..We assessed whether warfarin reduced risk of major stroke, arterial embolism, or other intracranial haemorrhage compared with aspirin in elderly patients.
  13. ncbi Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association
    Jane W Newburger
    Circulation 110:2747-71. 2004
    ..Coronary artery aneurysms or ectasia develop in approximately 15% to 25% of untreated children and may lead to ischemic heart disease or sudden death...
  14. ncbi Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies
    Enrico Flossmann
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Lancet 369:1603-13. 2007
    Randomised trials have shown that aspirin reduces the short-term risk of recurrent colorectal adenomas in patients with a history of adenomas or cancer, but large trials have shown no effect in primary prevention of colorectal cancer ..
  15. ncbi Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues
    Michael J Thun
    Department of Epidemiology and Surveillance Research, American Cancer Society, National Home Office, Atlanta, GA 30329 4251, USA
    J Natl Cancer Inst 94:252-66. 2002
    ..Finally, we suggest research opportunities that may help to accelerate the future clinical application of NSAIDs for cancer prevention or treatment...
  16. ncbi The role of aspirin in cancer prevention
    Michael J Thun
    Epidemiology Research Program, American Cancer Society, 250 Williams Street, Atlanta, GA 30303 1002, USA michael thun cancer org
    Nat Rev Clin Oncol 9:259-67. 2012
    Clinical guidelines for prophylactic aspirin use currently only consider the cardiovascular benefits of aspirin, weighed against the potential harm from aspirin-induced bleeding...
  17. ncbi Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation
    Yee Ping Sun
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 282:9323-34. 2007
    ..stereochemistry of the conjugated double bonds and chirality of alcohols present in resolvin D1 (RvD1) and its aspirin-triggered 17R epimer (AT-RvD1) with compounds prepared by total organic synthesis...
  18. ncbi Aspirin for preventing the recurrence of venous thromboembolism
    Cecilia Becattini
    Division of Internal and Cardiovascular Medicine and Stroke Unit, Department of Internal Medicine, University of Perugia, Perugia, Italy
    N Engl J Med 366:1959-67. 2012
    ..Extending anticoagulation prevents recurrences but is associated with increased bleeding. The benefit of aspirin for the prevention of recurrent venous thromboembolism is unknown.
  19. pmc Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor
    Mauro Perretti
    1 Department of Biochemical Pharmacology, William Harvey Research Institute, Bart s and the London School of Medicine, Queen Mary University of London, Charterhouse Square, London, UK 2 M P and N C contributed equally to this paper
    Nat Med 8:1296-302. 2002
    b>Aspirin (ASA) and dexamethasone (DEX) are widely used anti-inflammatory agents yet their mechanism(s) for blocking polymorphonuclear neutrophil (PMN) accumulation at sites of inflammation remains unclear...
  20. pmc Aspirin for primary prevention of cardiovascular events in people with diabetes: meta-analysis of randomised controlled trials
    Giorgia De Berardis
    Department of Clinical Pharmacology and Epidemiology, Consorzio Mario Negri Sud, Via Nazionale 8 A, 66030 S Maria Imbaro, Italy
    BMJ 339:b4531. 2009
    To evaluate the benefits and harms of low dose aspirin in people with diabetes and no cardiovascular disease.
  21. ncbi Clopidogrel with or without omeprazole in coronary artery disease
    Deepak L Bhatt
    Veterans AffairsBoston Healthcare System, Brigham and Women s Hospital, Boston, MA 02132, USA
    N Engl J Med 363:1909-17. 2010
    ..Recently, concerns have been raised about the potential for PPIs to blunt the efficacy of clopidogrel...
  22. ncbi Prevention of preeclampsia and intrauterine growth restriction with aspirin started in early pregnancy: a meta-analysis
    Emmanuel Bujold
    Department of Obstetrics and Gynecology, Faculty of Medicine, Laval University, Quebec, Canada
    Obstet Gynecol 116:402-14. 2010
    To estimate the effect of low-dose aspirin started in early pregnancy on the incidence of preeclampsia and intrauterine growth restriction (IUGR).
  23. ncbi Prasugrel versus clopidogrel in patients with acute coronary syndromes
    Stephen D Wiviott
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 357:2001-15. 2007
    Dual-antiplatelet therapy with aspirin and a thienopyridine is a cornerstone of treatment to prevent thrombotic complications of acute coronary syndromes and percutaneous coronary intervention.
  24. ncbi A randomized trial of aspirin to prevent colorectal adenomas
    John A Baron
    Norris Cotton Cancer Center, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    N Engl J Med 348:891-9. 2003
    Laboratory and epidemiologic data suggest that aspirin has an antineoplastic effect in the large bowel.
  25. pmc Aspirin intake and survival after breast cancer
    Michelle D Holmes
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Clin Oncol 28:1467-72. 2010
    Animal and in vitro studies suggest that aspirin may inhibit breast cancer metastasis. We studied whether aspirin use among women with breast cancer decreased their risk of death from breast cancer.
  26. pmc Aspirin and cancer: has aspirin been overlooked as an adjuvant therapy?
    R E Langley
    MRC Clinical Trials Unit, London, UK
    Br J Cancer 105:1107-13. 2011
    b>Aspirin inhibits the enzyme cyclooxygenase (Cox), and there is a significant body of epidemiological evidence demonstrating that regular aspirin use is associated with a decreased incidence of developing cancer...
  27. ncbi Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics, and Statistics, Queen Mary University of London, London UK
    Lancet Oncol 10:501-7. 2009
    Evidence clearly shows a chemopreventive effect for aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) on colorectal cancer and probably other cancer types; however, data on the risk-benefit profile for cancer prevention ..
  28. ncbi Low-dose aspirin for primary prevention of atherosclerotic events in patients with type 2 diabetes: a randomized controlled trial
    Hisao Ogawa
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto City, 860 8556, Japan
    JAMA 300:2134-41. 2008
    Previous trials have investigated the effects of low-dose aspirin on primary prevention of cardiovascular events, but not in patients with type 2 diabetes.
  29. ncbi Activation of the caspase-8/Bid and Bax pathways in aspirin-induced apoptosis in gastric cancer
    Qing Gu
    Department of Gastroenterology, First Hospital, Peking University, Beijing, People s Republic of China
    Carcinogenesis 26:541-6. 2005
    b>Aspirin-induced apoptosis is one of the important mechanisms for its antitumour effect against gastric cancer. We aimed at investigating the involvement of bcl-2 family members in the apoptotic pathway in gastric cancer...
  30. pmc A strategy to reduce cardiovascular disease by more than 80%
    N J Wald
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and The London, Queen Mary s School of Medicine and Dentistry, University of London, London EC1M 6BQ
    BMJ 326:1419. 2003
    ..The strategy was to simultaneously reduce four cardiovascular risk factors (low density lipoprotein cholesterol, blood pressure, serum homocysteine, and platelet function) regardless of pretreatment levels...
  31. ncbi Stroke with intermittent atrial fibrillation: incidence and predictors during aspirin therapy. Stroke Prevention in Atrial Fibrillation Investigators
    R G Hart
    Department of Medicine, University of Texas Health Science Center, San Antonio 78284, USA
    J Am Coll Cardiol 35:183-7. 2000
    ..This study was performed to characterize the risk of stroke in elderly patients with recurrent intermittent atrial fibrillation (AF)...
  32. ncbi Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: an overview of their protective roles in catabasis
    Charles N Serhan
    Department of Anesthesiology, Perioperative and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Prostaglandins Other Lipid Mediat 73:155-72. 2004
    ..b>Aspirin treatment impacts biosynthesis of these compounds and a related series by triggering endogenous formation of the ..
  33. ncbi Acetylsalicylic acid-induced oxidative stress, cell cycle arrest, apoptosis and mitochondrial dysfunction in human hepatoma HepG2 cells
    Haider Raza
    Department of Biochemistry, Faculty of Medicine and Health Sciences, UAE University, POBox 17666, Al Ain, United Arab Emirates
    Eur J Pharmacol 668:15-24. 2011
    It is widely accepted that non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin, reduce the risk of cancer...
  34. ncbi The mechanism of action of aspirin
    J R Vane
    The William Harvey Research Institute, St Bartholomew s and The Royal London School of Medicine, Charterhouse Square, London EC1M 6BQ, UK
    Thromb Res 110:255-8. 2003
    ..This drug was named "Aspirin" and became the most widely used medicine of all time...
  35. ncbi Risks of thromboembolism and bleeding with thromboprophylaxis in patients with atrial fibrillation: A net clinical benefit analysis using a 'real world' nationwide cohort study
    Jonas Bjerring Olesen
    Department of Cardiology, Post 635, Copenhagen University Hospital Gentofte, Niels Andersens Vej 65, 2900 Hellerup, Denmark
    Thromb Haemost 106:739-49. 2011
    ..Also, the risk of bleeding was increased with both VKA and ASA treatment, but the net clinical benefit was clearly positive, in favour of VKA in patients with increased risk of stroke/thromboembolism...
  36. ncbi Current trial-associated outcomes with warfarin in prevention of stroke in patients with nonvalvular atrial fibrillation: a meta-analysis
    Shikhar Agarwal
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Ohio, USA
    Arch Intern Med 172:623-31; discussion 631-3. 2012
    ..We performed a meta-analysis of safety and efficacy outcomes in patients with AF treated with warfarin for stroke prevention in large contemporary randomized controlled trials (RCTs)...
  37. pmc Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing
    C N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 192:1197-204. 2000
    b>Aspirin therapy inhibits prostaglandin biosynthesis without directly acting on lipoxygenases, yet via acetylation of cyclooxygenase 2 (COX-2) it leads to bioactive lipoxins (LXs) epimeric at carbon 15 (15-epi-LX, also termed aspirin-..
  38. pmc Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statins
    Matthew Spite
    Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Circ Res 107:1170-84. 2010
    ..Here, we overview and update the biosynthesis and actions of proresolving lipid mediators, highlighting their diverse protective roles relevant to vascular systems and their relation to aspirin and statin therapies.
  39. ncbi Esomeprazole compared with famotidine in the prevention of upper gastrointestinal bleeding in patients with acute coronary syndrome or myocardial infarction
    Fook Hong Ng
    Department of Medicine and Geriatric, Ruttonjee Hospital, Hong Kong, China
    Am J Gastroenterol 107:389-96. 2012
    ..in patients with acute coronary syndrome (ACS) or ST elevation myocardial infarction (STEMI) receiving aspirin, clopidogrel, and enoxaparin or thrombolytics...
  40. ncbi Low-dose aspirin for preventing recurrent venous thromboembolism
    Timothy A Brighton
    Department of Haematology, South Eastern Area Laboratory Services SEALS, Prince of Wales Hospital, Sydney, Australia
    N Engl J Med 367:1979-87. 2012
    Patients who have had a first episode of unprovoked venous thromboembolism have a high risk of recurrence after anticoagulants are discontinued. Aspirin may be effective in preventing a recurrence of venous thromboembolism.
  41. pmc Aspirin-triggered lipoxin A4 attenuates LPS-induced pro-inflammatory responses by inhibiting activation of NF-κB and MAPKs in BV-2 microglial cells
    Yan Ping Wang
    Department of Anesthesiology and Critical Care, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Neuroinflammation 8:95. 2011
    ..Lipoxins (LXs) and aspirin-triggered LXs (ATLs) are considered to act as 'braking signals' in inflammation...
  42. ncbi Randomized double-blind assessment of the ONSET and OFFSET of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease: the ONSET/OFFSET study
    Paul A Gurbel
    Sinai Center for Thrombosis Research, Cardiac Catheterization Laboratory, 2401 W Belvedere Ave, Baltimore, MD 21215, USA
    Circulation 120:2577-85. 2009
    ..This is the first study to compare the onset and offset of platelet inhibition (IPA) with ticagrelor using the PLATO (PLATelet inhibition and patient Outcomes) trial loading dose (180 mg) with a high loading dose (600 mg) of clopidogrel...
  43. ncbi Continuation of low-dose aspirin therapy in peptic ulcer bleeding: a randomized trial
    Joseph J Y Sung
    Institute of Digestive Disease, Chinese University of Hong Kong, Sha Tin, New Territories, Hong Kong
    Ann Intern Med 152:1-9. 2010
    It is uncertain whether aspirin therapy should be continued after endoscopic hemostatic therapy in patients who develop peptic ulcer bleeding while receiving low-dose aspirin.
  44. pmc Aspirin in the chemoprevention of colorectal neoplasia: an overview
    Andrew T Chan
    Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA
    Cancer Prev Res (Phila) 5:164-78. 2012
    Considerable evidence supports the effectiveness of aspirin for chemoprevention of colorectal cancer (CRC) in addition to its well-established benefits in the prevention of vascular disease...
  45. ncbi Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta
    M Yuan
    Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Science 293:1673-7. 2001
    ..These findings implicate an inflammatory process in the pathogenesis of insulin resistance in obesity and type 2 diabetes mellitus and identify the IKKbeta pathway as a target for insulin sensitization...
  46. ncbi Clopidogrel with aspirin in acute minor stroke or transient ischemic attack
    Yongjun Wang
    Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    N Engl J Med 369:11-9. 2013
    Stroke is common during the first few weeks after a transient ischemic attack (TIA) or minor ischemic stroke. Combination therapy with clopidogrel and aspirin may provide greater protection against subsequent stroke than aspirin alone.
  47. ncbi Aspirin induces apoptosis in mesenchymal stem cells requiring Wnt/beta-catenin pathway
    L Deng
    Research Center for Cardiovascular Regenerative Medicine, Ministry of Health, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Science and Peking Union Medicine College, Beijing 100037, China
    Cell Prolif 42:721-30. 2009
    ..We have previously observed that aspirin, a widely used anti-inflammatory drug, inhibits MSC proliferation...
  48. ncbi Low-dose aspirin in the primary prevention of cancer: the Women's Health Study: a randomized controlled trial
    Nancy R Cook
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    JAMA 294:47-55. 2005
    Basic research and observational evidence as well as results from trials of colon polyp recurrence suggest a role for aspirin in the chemoprevention of cancer.
  49. pmc Aspirin "resistance" and risk of cardiovascular morbidity: systematic review and meta-analysis
    George Krasopoulos
    University Health Network, Division of Cardiovascular Surgery, Toronto General Hospital
    BMJ 336:195-8. 2008
    To determine if there is a relation between aspirin "resistance" and clinical outcomes in patients with cardiovascular disease.
  50. ncbi Reduced expression of COXs and production of prostaglandin E(2) in patients with nasal polyps with or without aspirin-intolerant asthma
    Jordi Roca-Ferrer
    Immunoallergia Respiratoria Clinica i Experimental, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    J Allergy Clin Immunol 128:66-72.e1. 2011
    Researchers have debated whether regulation of the COX enzymes (COX-1 and COX-2), which mediate production of prostaglandins (PGs), affects the pathogenesis of nasal polyps (NPs) and aspirin-intolerant asthma (AIA).
  51. ncbi Interindividual variability in the response to oral antiplatelet drugs: a position paper of the Working Group on antiplatelet drugs resistance appointed by the Section of Cardiovascular Interventions of the Polish Cardiac Society, endorsed by the Working
    Wiktor Kuliczkowski
    3rd Department of Cardiology, Silesian Center for Heart Diseases, Zabrze, Poland
    Eur Heart J 30:426-35. 2009
    ..The efficacy of acetylsalicylic acid (ASA, aspirin) and clopidogrel in decreasing the risk of adverse events in coronary heart disease patients has been well ..
  52. ncbi Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis
    Marc I Chimowitz
    Department of Neurology, School of Medicine, Emory University, Atlanta, USA
    N Engl J Med 352:1305-16. 2005
    Atherosclerotic intracranial arterial stenosis is an important cause of stroke. Warfarin is commonly used in preference to aspirin for this disorder, but these therapies have not been compared in a randomized trial.
  53. pmc Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells
    Farhat V N Din
    Colon Cancer Genetics Group and Academic Coloproctology, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council Human Genetics Unit, Western General Hospital Edinburgh, United Kingdom
    Gastroenterology 142:1504-15.e3. 2012
    b>Aspirin reduces the incidence of and mortality from colorectal cancer (CRC) by unknown mechanisms. Cancer cells have defects in signaling via the mechanistic target of rapamycin (mTOR), which regulates proliferation...
  54. ncbi Anticoagulants (thrombin inhibitors) and aspirin synergize with P2Y12 receptor antagonism in thrombosis
    Patrick Andre
    Millennium Pharmaceuticals, Inc, 256 E Grand Ave, South San Francisco, Calif 9408, USA
    Circulation 108:2697-703. 2003
    ..This study was designed to determine whether (1) P2Y12 antagonism synergizes with other antithrombotics and (2) anticoagulants (thrombin inhibitors) affect the antithrombotic activity elicited by P2Y12 antagonism...
  55. ncbi Impact of medication therapy discontinuation on mortality after myocardial infarction
    P Michael Ho
    Denver Veterans Affairs Medical Center, CO, USA
    Arch Intern Med 166:1842-7. 2006
    ....
  56. ncbi Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimers
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Lipids 39:1125-32. 2004
    ..b>Aspirin treatment initiates a related epimeric series by triggering endogenous formation of the 17R-D series resolvins ..
  57. ncbi Risk of bleeding with single, dual, or triple therapy with warfarin, aspirin, and clopidogrel in patients with atrial fibrillation
    Morten L Hansen
    Department of Cardiology, Copenhagen University Hospital Gentofte, Niels Andersens Vej 65 2900, Hellerup, Copenhagen, Denmark
    Arch Intern Med 170:1433-41. 2010
    ..Patients with atrial fibrillation (AF) often require anticoagulation and platelet inhibition, but data are limited on the bleeding risk of combination therapy...
  58. ncbi A new combined test with flowcytometric basophil activation and determination of sulfidoleukotrienes is useful for in vitro diagnosis of hypersensitivity to aspirin and other nonsteroidal anti-inflammatory drugs
    M L Sanz
    Department of Allergology and Clinical Immunology, University of Navarra, Pamplona, Spain
    Int Arch Allergy Immunol 136:58-72. 2005
    ..We assessed whether nonsteroidal anti-inflammatory drugs (NSAIDs) may provoke blood basophil activation in vitro in aspirin- and NSAID-hypersensitive patients, as detected by a flowcytometric technique using the CD63 marker--..
  59. ncbi Effects of low-dose aspirin on acute inflammatory responses in humans
    Thea Morris
    Division of Medicine, University College London, Centre for Clinical Pharmacology and Therapeutics, London, United Kingdom
    J Immunol 183:2089-96. 2009
    b>Aspirin is a unique nonsteroidal anti-inflammatory drug; at high doses (aspirin(high), 1g), it is anti-inflammatory stemming from the inhibition of cyclooxygenase and proinflammatory signaling pathways including NF-kappaB, but is ..
  60. ncbi Platelet function profiles in patients with type 2 diabetes and coronary artery disease on combined aspirin and clopidogrel treatment
    Dominick J Angiolillo
    Division of Cardiology, University of Florida, Shands Jacksonville, 655 West 8th St, Jacksonville, FL 32209, USA
    Diabetes 54:2430-5. 2005
    To assess platelet function profiles in diabetic and nondiabetic patients on aspirin and clopidogrel therapy, two patient populations were included to investigate the 1) acute effects of a 300-mg clopidogrel loading dose (group 1, n = 52)..
  61. ncbi Posttreatment with aspirin-triggered lipoxin A4 analog attenuates lipopolysaccharide-induced acute lung injury in mice: the role of heme oxygenase-1
    Sheng wei Jin
    Department of Anesthesiology, Second Affiliated Hospital, Wenzhou Medical College, Wenzhou, China
    Anesth Analg 104:369-77. 2007
    ..We hypothesized that posttreatment with 15-epi-16-parafluoro-phenoxy lipoxin A4 (ATL) could attenuate lipopolysaccharide (LPS)-induced acute lung injury in mice...
  62. ncbi Effect of aspirin and NSAIDs on risk and survival from colorectal cancer
    Farhat V N Din
    Colon Cancer Genetics Group and Academic Coloproctology, Institute of Genetics and Molecular Medicine, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK
    Gut 59:1670-9. 2010
    Previous studies have shown that aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) lower colorectal cancer (CRC) risk. However, the lowest effective NSAID dose, treatment duration, and effects on survival are not defined...
  63. pmc Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial
    John Burn
    Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK
    Lancet 378:2081-7. 2011
    Observational studies report reduced colorectal cancer in regular aspirin consumers. Randomised controlled trials have shown reduced risk of adenomas but none have employed prevention of colorectal cancer as a primary endpoint...
  64. ncbi EAACI/GA2LEN guideline: aspirin provocation tests for diagnosis of aspirin hypersensitivity
    E Nizankowska-Mogilnicka
    Department of Medicine, Jagiellonian University School of Medicine, Krakow, Poland
    Allergy 62:1111-8. 2007
    b>Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most common causes of adverse drug reactions. Majority of them are of the hypersensitivity type...
  65. pmc Aspirin but not ibuprofen use is associated with reduced risk of prostate cancer: a PLCO study
    F M Shebl
    Department of Human Health and Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA
    Br J Cancer 107:207-14. 2012
    ..Although most epidemiological studies suggest that non-steroidal anti-inflammatory drug use is inversely associated with prostate cancer risk, the magnitude and specificity of this association remain unclear...
  66. ncbi Dual antiplatelet therapy versus aspirin alone in patients undergoing transcatheter aortic valve implantation
    Gian Paolo Ussia
    Division of Cardiology, Ferrarotto Hospital, University of Catania, Italy
    Am J Cardiol 108:1772-6. 2011
    Dual antiplatelet therapy (DAPT) with clopidogrel and aspirin is a widely accepted strategy in patients undergoing transcatheter aortic valve implantation (TAVI), but this approach is not evidence based...
  67. ncbi Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding
    Francis K L Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong, China
    N Engl J Med 352:238-44. 2005
    Concurrent therapy with a proton-pump inhibitor is a standard treatment for patients receiving aspirin who are at risk for ulcer. Current U.S...
  68. ncbi A comparison of platelet function tests and thromboxane metabolites to evaluate aspirin response in healthy individuals and patients with coronary artery disease
    Erik Lerkevang Grove
    Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus, Denmark
    Thromb Haemost 103:1245-53. 2010
    ..5 or 0.75 mM and VerifyNow Aspirin. Patients with stable coronary artery disease (n=43) and healthy individuals (n=21) were included...
  69. ncbi Efficacy of esomeprazole (20 mg once daily) for reducing the risk of gastroduodenal ulcers associated with continuous use of low-dose aspirin
    Neville Yeomans
    School of Medicine, University of Western Sydney, Sydney, Australia
    Am J Gastroenterol 103:2465-73. 2008
    Low-dose aspirin is standard treatment for prevention of cardiovascular events in at-risk patients...
  70. ncbi Aspirin as adjuvant therapy for colorectal cancer--reinterpreting paradigms
    Whay Kuang Chia
    National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610, Singapore
    Nat Rev Clin Oncol 9:561-70. 2012
    A high-quality body of evidence supports the use of aspirin in reducing sporadic and hereditary adenomatous polyps, and numerous observational studies point to a reduction in colorectal cancer (CRC) risk...
  71. ncbi Early administration of low-dose aspirin for the prevention of preterm and term preeclampsia: a systematic review and meta-analysis
    Stéphanie Roberge
    Department of Social and Preventive Medicine, Universite Laval, Quebec City, Que, Canada
    Fetal Diagn Ther 31:141-6. 2012
    To compare the effect of early administration of aspirin on the risk of preterm and term preeclampsia.
  72. ncbi Effects of Helicobacter pylori infection on long-term risk of peptic ulcer bleeding in low-dose aspirin users
    Francis K L Chan
    Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong
    Gastroenterology 144:528-35. 2013
    Current guidelines recommend testing for Helicobacter pylori infection among users of low-dose aspirin (ASA) who are at high risk for developing ulcers...
  73. pmc COX-2 expression predicts worse breast cancer prognosis and does not modify the association with aspirin
    Michelle D Holmes
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Breast Cancer Res Treat 130:657-62. 2011
    Some previous studies have found worse prognosis among cyclooxygenase-2 (COX-2)-expressing breast cancers. Aspirin and NSAIDs inhibit COX-2...
  74. ncbi Aspirin and the risk of colorectal cancer in relation to the expression of COX-2
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 356:2131-42. 2007
    Regular use of aspirin reduces the risk of a colorectal neoplasm, but the mechanism by which aspirin affects carcinogenesis in the colon is not well understood.
  75. ncbi Prevention of perinatal death and adverse perinatal outcome using low-dose aspirin: a meta-analysis
    S Roberge
    Department of Social and Preventive Medicine, Faculty of Medicine, Universite Laval, Quebec City, QC, Canada
    Ultrasound Obstet Gynecol 41:491-9. 2013
    To compare early vs late administration of low-dose aspirin on the risk of perinatal death and adverse perinatal outcome.
  76. pmc Aspirin treatment of mice infected with Trypanosoma cruzi and implications for the pathogenesis of Chagas disease
    Shankar Mukherjee
    Division of Parasitology, Department of Pathology, Albert Einstein College of Medicine, New York City, New York, United States of America
    PLoS ONE 6:e16959. 2011
    ..cruzi infection (Brazil strain) beginning 5 days post infection (dpi) with aspirin (ASA) increased mortality (2-fold) and parasitemia (12-fold)...
  77. pmc Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acute respiratory distress syndrome
    Hollis R O'Neal
    Department of Medicine, Section of Pulmonary and Critical Care Medicine, Louisiana State University Health Sciences Center, Baton Rouge, LA, USA
    Crit Care Med 39:1343-50. 2011
    ..We also investigated the effect of combined prehospital use of both statins and aspirin.
  78. ncbi Dabigatran with or without concomitant aspirin compared with warfarin alone in patients with nonvalvular atrial fibrillation (PETRO Study)
    Michael D Ezekowitz
    Lankenau Institute for Medical Research and The Heart Center, Wynnewood, PA, USA
    Am J Cardiol 100:1419-26. 2007
    ..to receive blinded doses of 50-, 150-, or 300-mg dabigatran twice daily alone or combined with 81- or 325-mg aspirin or open-label warfarin administered to achieve an international normalized ratio of 2 to 3 for 12 weeks...
  79. ncbi Aspirin or enoxaparin thromboprophylaxis for patients with newly diagnosed multiple myeloma treated with lenalidomide
    Alessandra Larocca
    Myeloma Unit, Division of Hematology, University of Torino, Azienda Ospedaliero Universitaria AOU S Giovanni Battista, Torino, Italy
    Blood 119:933-9; quiz 1093. 2012
    ..randomized substudy of a phase 3 trial compared the efficacy and safety of thromboprophylaxis with low-dose aspirin (ASA) or low-molecular-weight heparin (LMWH) in patients with newly diagnosed MM, treated with lenalidomide and ..
  80. pmc Prevention of peptic ulcers with esomeprazole in patients at risk of ulcer development treated with low-dose acetylsalicylic acid: a randomised, controlled trial (OBERON)
    James M Scheiman
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Heart 97:797-802. 2011
    ....
  81. ncbi Association of PTGER gene family polymorphisms with aspirin intolerant asthma in Korean asthmatics
    Byung Lae Park
    Department of Life Science, Sogang University, Seoul, Korea
    BMB Rep 43:445-9. 2010
    b>Aspirin-intolerant asthma (AIA) is characterized by severe asthmatic attack after ingestion of aspirin and/or non-steroidal anti-inflammatory drugs...
  82. ncbi Effect of single nucleotide polymorphisms within the interleukin-4 promoter on aspirin intolerance in asthmatics and interleukin-4 promoter activity
    Byung Soo Kim
    Division of Molecular and Life Sciences, College of Science and Technology, Hanyang University, Sangrok Ku, Ansan, Gyeonggi Do, Korea
    Pharmacogenet Genomics 20:748-58. 2010
    b>Aspirin affects interleukin-4 (IL-4) synthesis; however, the genetic role of IL-4 has not been evaluated in asthmatics with aspirin hypersensitivity...
  83. ncbi Aspirin sensitizes cancer cells to TRAIL-induced apoptosis by reducing survivin levels
    Meiling Lu
    Cell Death Regulation Laboratory, Department of Medicine and Cell and Molecular Biology, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Clin Cancer Res 14:3168-76. 2008
    ..We examined whether the nonsteroidal anti-inflammatory drug aspirin sensitized cancer cells to TRAIL agonists in vitro and in vivo and investigated the underlying mechanism.
  84. ncbi Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseases
    T E Van Dyke
    Department of Periodontology and Oral Biology, Boston University, Goldman School of Dental Medicine, 100 East Newton Street, Boston, MA 02118, USA
    J Dent Res 82:82-90. 2003
    ....
  85. ncbi The flow-cytometric determination of basophil activation induced by aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) is useful for in vitro diagnosis of the NSAID hypersensitivity syndrome
    P Gamboa
    Allergy Unit, Hospital Basurto, Bilbao, Spain
    Clin Exp Allergy 34:1448-57. 2004
    ..Today, it is still claimed that no in vitro diagnostic tests exist for that condition and that the only way to confirm the diagnosis is a provocation challenge...
  86. pmc Activation of lipoxin A(4) receptors by aspirin-triggered lipoxins and select peptides evokes ligand-specific responses in inflammation
    N Chiang
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 191:1197-208. 2000
    Lipoxin (LX) A(4) and aspirin-triggered LX (ATL) are endogenous lipids that regulate leukocyte trafficking via specific LXA(4) receptors (ALXRs) and mediate antiinflammation and resolution...
  87. ncbi Clinical and pathologic perspectives on aspirin sensitivity and asthma
    Donald D Stevenson
    Division of Allergy, Asthma and Immunology and the Department of Medicine, Scripps Clinic and the Scripps Research Institute, La Jolla, USA
    J Allergy Clin Immunol 118:773-86; quiz 787-8. 2006
    b>Aspirin and other nonsteroidal anti-inflammatory drugs that inhibit COX-1 induce unique nonallergic reactions, consisting of attacks of rhinitis and asthma...
  88. ncbi Evaluation of dose-related effects of aspirin on platelet function: results from the Aspirin-Induced Platelet Effect (ASPECT) study
    Paul A Gurbel
    Sinai Center for Thrombosis Research, Hoffberger Bldg, Suite 56, 2401 W Belvedere Ave, Baltimore, MD 21215, USA
    Circulation 115:3156-64. 2007
    The antiplatelet effect of aspirin is attributed to platelet cyclooxygenase-1 inhibition...
  89. ncbi Antiplatelet agents for prevention of pre-eclampsia: a meta-analysis of individual patient data
    Lisa M Askie
    Centre for Perinatal Health Services Research, University of Sydney, Sydney, Australia
    Lancet 369:1791-8. 2007
    ..Antiplatelet agents, especially low-dose aspirin, might prevent or delay pre-eclampsia, and thereby improve outcome...
  90. ncbi Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial
    Shamir R Mehta
    McMaster University and Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada
    Lancet 376:1233-43. 2010
    Clopidogrel and aspirin are the most commonly used antiplatelet therapies for percutaneous coronary intervention (PCI)...
  91. pmc Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke
    Ralph L Sacco
    Miller School of Medicine, University of Miami, Miami, USA
    N Engl J Med 359:1238-51. 2008
    Recurrent stroke is a frequent, disabling event after ischemic stroke. This study compared the efficacy and safety of two antiplatelet regimens--aspirin plus extended-release dipyridamole (ASA-ERDP) versus clopidogrel.
  92. ncbi Leukotriene-receptor expression on nasal mucosal inflammatory cells in aspirin-sensitive rhinosinusitis
    Ana R Sousa
    Guy s, King s and St Thomas School of Medicine, London, United Kingdom
    N Engl J Med 347:1493-9. 2002
    Patients with asthma who have aspirin sensitivity have greater cysteinyl leukotriene production and greater airway hyperresponsiveness to the effects of inhaled cysteinyl leukotrienes than their aspirin-tolerant counterparts...
  93. ncbi A randomized study assessing the impact of cilostazol on platelet function profiles in patients with diabetes mellitus and coronary artery disease on dual antiplatelet therapy: results of the OPTIMUS-2 study
    Dominick J Angiolillo
    Division of Cardiology, University of Florida College of Medicine at Shands Jacksonville, Jacksonville, FL 32209, USA
    Eur Heart J 29:2202-11. 2008
    ..The aim of this pilot study was to assess the functional impact of cilostazol in T2DM patients on standard aspirin and clopidogrel treatment.
  94. ncbi Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: a double-blind comparison to clopidogrel with aspirin
    Steen Husted
    Department of Medicine and Cardiology, Arhus University Hospital, Denmark
    Eur Heart J 27:1038-47. 2006
    ..This double-blind, parallel-group study was conducted to assess the pharmacodynamics, pharmacokinetics, and safety of AZD6140, the first oral, reversible adenosine diphosphate (ADP) receptor antagonist...
  95. ncbi Prevalence of asthma, aspirin intolerance, nasal polyposis and chronic obstructive pulmonary disease in a population-based study
    J Hedman
    Department of Respiratory Medicine, Tampere University Hospital, Finland
    Int J Epidemiol 28:717-22. 1999
    ..The prevalence and relation to asthma of aspirin intolerance, nasal polyposis, allergic rhinitis and smoking habits were also examined.
  96. ncbi Aspirin dose for the prevention of cardiovascular disease: a systematic review
    Charles L Campbell
    Gill Heart Institute, University of Kentucky, Lexington, USA
    JAMA 297:2018-24. 2007
    More than 50 million US adults take aspirin regularly for long-term prevention of cardiovascular disease, typically either 81 mg/d or 325 mg/d. Controversy remains regarding the most appropriate long-term daily dose.
  97. ncbi Aspirin for prevention of cardiovascular events in a general population screened for a low ankle brachial index: a randomized controlled trial
    F Gerald R Fowkes
    Centre for Population Health Sciences, University of Edinburgh, Scotland
    JAMA 303:841-8. 2010
    ..Screening for a low ABI can identify an asymptomatic higher risk group potentially amenable to preventive treatments...
  98. ncbi Selecting patients with atrial fibrillation for anticoagulation: stroke risk stratification in patients taking aspirin
    Brian F Gage
    Division of General Medical Sciences, Washington University School of Medicine Campus Box 8005, 660 S Euclid Ave, St Louis, MO 63110, USA
    Circulation 110:2287-92. 2004
    ..Although adjusted-dose warfarin is superior to aspirin for reducing stroke in AF, the absolute risk reduction of warfarin depends on the stroke rate with aspirin...
  99. ncbi Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent
    Fabiana S Machado
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27705, USA
    Nat Med 12:330-4. 2006
    Control of inflammation is crucial to prevent damage to the host during infection. Lipoxins and aspirin-triggered lipoxins are crucial modulators of proinflammatory responses; however, their intracellular mechanisms have not been ..
  100. ncbi A possible association of EMID2 polymorphisms with aspirin hypersensitivity in asthma
    Charisse Flerida A Pasaje
    Department of Life Science, Sogang University, 1 Shinsu dong, Mapo gu, Seoul, 121 742, Republic of Korea
    Immunogenetics 63:13-21. 2011
    b>Aspirin-intolerant asthma (AIA) is an asthma phenotype characterized by the development of bronchoconstriction following ingestion of aspirin...
  101. ncbi Prothrombotic and hemorrhagic effects of aspirin
    Omar Aguejouf
    Laboratoire d Hématologie Université Victor Segalen Bordeaux 2, Bordeaux, France
    Clin Appl Thromb Hemost 15:523-8. 2009
    b>Aspirin remains the most widely used drug for prevention of vascular events...

Research Grants74

  1. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..Complications and therapy under study include aspirin, arginine, sildenafil for pulmonary hypertension, antioxidant supplementation, combination therapy for ..
  2. Mechanism of action of omega-3 fatty acids in brain injury
    CHARLES NICHOLAS SERHAN; Fiscal Year: 2010
    ..upon the innovative concept that the recently identified DHA-derived mediators, neuroprotectin D1 (NPD1) and aspirin-triggered (AT)-neuroprotectin D1 (AT-NPD1), inhibit ischemia-reperfusion mediated leukocyte infiltration and pro-..
  3. Prevention of Inherited Retinal Diseases by Therapeutic Rare Earth Nanoparticles
    JAMES FRANCIS MCGINNIS; Fiscal Year: 2010
    ..We think of the nanoceria as being analogous to an aspirin for blindness in that they won't cure the primary defect but will decrease the severity of the disease...
  4. A Clinical Trial of Aspirin and Simvastatin in Pulmonary Arterial Hypertension
    Steven Kawut; Fiscal Year: 2009
    ..HMG-CoA reductase inhibitors (statins) and aspirin are very safe, highly-effective cardiovascular therapies used by millions of people...
  5. PROSPECTIVE STUDIES OF DIET AND CANCER IN MEN AND WOMEN
    Walter C Willett; Fiscal Year: 2010
    ..Use of statins, aspirin, and NSAID's and of insulinemia (weight and weight gain, dietary insulin index, plasma C-peptide, and ..
  6. Development of Montelukast Delivery System for Childhood Asthma
    Je Phil Ryoo; Fiscal Year: 2013
    ..of asthmatic responses, including allergen-induced, exercise- induced, cold-air-hyperventilation-induced, and aspirin-induced asthma (Wright et al 1998)...
  7. GI-Safer Formulation of Indomethacin for use in Preterm Neonates
    UPENDRA K MARATHI; Fiscal Year: 2010
    ..available non-steroidal anti-inflammatory drugs (NSAIDs), including indomethacin, naproxen, ibuprofen, and aspirin, cause significant GI damage...
  8. Adjunctive Use of Apyrase to Fibrinolytic Therapy
    Ridong Chen; Fiscal Year: 2013
    ..The current regimen, including tissue plasminogen activator, aspirin, clopidogrel and heparin, still induces inadequate coronary reperfusion in 30-40% of patients and early ..
  9. Novel Antithrombotic Diadenosine Tetraphosphate Analogs
    IVAN B YANACHKOV; Fiscal Year: 2013
    ..The main antiplatelet drugs in clinical use today - aspirin and clopidogrel - target platelet COX-1 and P2Y12 platelet receptors, respectively...
  10. Gender Selectivity to Colon Cancer Chemoprevention by NSAIDS
    RAMESH K contact WALI; Fiscal Year: 2010
    ..ulcers, GI bleeding, hemorrhagic strokes etc, thereby cautioning that the risks may outweigh the benefits of aspirin and NSAIDS in preventing CRC for average risk use...
  11. Role of Neutrophil-Platelet Interactions in Vascular Occlusive Disorders
    Nauder Faraday; Fiscal Year: 2010
    ..Antiplatelet therapy with aspirin, clopidogrel, or their combination, is currently standard of care for prevention of myocardial infarction (MI), ..
  12. Novel mechanisms by which aspirin might protect against atherosclerosis
    Sampath Parthasarathy; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Aspirin ('acetylsalicylic acid') inhibits the formation of prostaglandins (PGs) that cause inflammation, swelling, pain and fever...
  13. Inhibition of Carboxylesterase Metabolism by Ethanol
    Robert B Parker; Fiscal Year: 2011
    ..drug oseltamivir;and 2) determine the effects of ethanol on the pharmacokinetics of the hCE2 substrate drug aspirin. With over 100 million people in the United States consuming ethanol and the growing number of drugs dependent on ..
  14. Flavonoids, esophageal/gastric cardia adenocarcinoma and Barretts Esophagus Risk
    Marilie D Gammon; Fiscal Year: 2013
    ..a modest reduction in risk of EA/GCA and BE in users of non-steroidal anti-inflammatory drugs (NSAIDS), including aspirin, which are COX-2 inhibitors. However, NSAIDS can have severe side effects so their clinical usage is limited...
  15. A Prospective Study of Diet and Prostate Cancer
    Edward Giovannucci; Fiscal Year: 2011
    ..goal is to better understand how dietary and other modifiable factors, including widely used medications such as aspirin and statins, influence prostate carcinogenesis at various stages, including after diagnosis, and to identify the ..
  16. Screening for allosteric modulators of the protease activated receptor 4
    Heidi E Hamm; Fiscal Year: 2013
    ..Currently available therapies, aspirin, clopidogrel, and ?IIb?3 inhibitors, do not fully attenuate platelet activation, can have delayed onset and long ..
  17. New Pathways in Thrombosis and Inflammation Mediated by Semaphorin-Plexin Signali
    Guy A Zimmerman; Fiscal Year: 2010
    ..be used independently or in combination with other antithrombotic therapies including cyclooxygenase inhibitors (aspirin), thienopyridines (clopidogrel), and anticoagulants (heparin, warfarin)...
  18. Pharmacogenomics of CVD risk Reduction
    ALAN SHULDINER; Fiscal Year: 2009
    ..Order Amish subjects, all of whom have been extensively characterized with respect to CVD (including response to aspirin) and in whom an 800 short tandem repeat marker genome scan has been completed...
  19. p53 Acetylation as a Mechanism in Chemoprevention by Aspirin
    JAYARAMA B GUNAJE; Fiscal Year: 2010
    ..provided by applicant): A vast amount of epidemiological, preclinical and clinical studies have revealed aspirin as a promising chemopreventive agent, particularly in epithelial carcinogenesis...
  20. Dietary control of angiogenesis in retinopathy models
    Lois Smith; Fiscal Year: 2013
    ..and negative contributions of enzymatic pathway(s) that produce the major bioactive PUFA metabolites (does aspirin, a COX inhibitor or Zileuton, a LOX inhibitor, or a Cyp450 interactive drug negate eating fish if it blocks ..
  21. Risk reduction through polyamine inhibition among colorectal carcinoma patients
    JASON ZELL; Fiscal Year: 2012
    ..1) will be reduction in rectal tissue levels of the polyamine putrescine, after a 12- week intervention of daily aspirin and dietary arginine restriction in 24 optimally-treated locally advanced colon cancer patients...
  22. Cohort Study of Glucosamine and Chondroitin Supplement Use and Cancer Risk
    Emily White; Fiscal Year: 2012
    ..Other anti-inflammatory drugs (e.g., aspirin) have been shown in some studies to reduce the risk of colorectal, breast, prostate, lung, and total cancer, but ..
  23. Targeting Inflammation in Type 2 Diabetes: Clinical Trial Using Salsalate
    Steven E Shoelson; Fiscal Year: 2010
    ..results from 2- to 4-week long, single-site clinical trials in T2D patients showed that high-doses of either aspirin (7 g/day) or salsalate (3.0 to 4...
  24. Cumulative Stress and CVD Risk in Middle-Aged and Older Women
    Michelle A Albert; Fiscal Year: 2013
    ..The WHS was initiated in 1992 as a randomized trial of aspirin and vitamin E in the primary prevention of cancer and cardiovascular disease among 39, 876 female health ..
  25. Vitamin D: a link to racial disparities in birth outcomes
    Lisa M Bodnar; Fiscal Year: 2012
    ..Perinatal Project (n=55,908;46% white;47% black) and the NICHD Maternal-Fetal Medicine Units Network High-Risk Aspirin Study (n=917 pregnancies;33% white, 57% black)...
  26. Chemopreventive effect of fish oil derived EPA in lung cancer
    Peiying Yang; Fiscal Year: 2013
    ..and prevention because approximately 70% of lung adenocarcinomas have overexpression of COX-2 and regular use of aspirin and other NSAIDs is associated with a reduced risk of developing lung cancer in animal models and smokers...
  27. Predictors of Progression from Barrett's Esophagus to esophageal adenocarcinoma
    Brian J Reid; Fiscal Year: 2010
    ..in Barrett's esophagus that predict progression to cancer as well as how diet, the use of common drugs like aspirin, and other lifestyle choices can change the likelihood of developing this cancer...
  28. Lipidomic and Transcriptome Signatures in Aspirin-Exacerbated Respiratory Disease
    Joshua A Boyce; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Aspirin-exacerbated respiratory disease (AERD) is characterized by persistent chronic inflammation of the upper and lower airways leading to chronic rhinosinusitis, nasal polyposis, and asthma...
  29. Who benefits from Colorectal Cancer Screening? A subgroup Analysis of the Minnes
    Aasma Shaukat; Fiscal Year: 2013
    ..Additionally, the effects of other baseline variables, such as co-morbidities and intake of aspirin on outcomes have not been reported...
  30. Histone deacetylases - therapeutic targets for functional restoration after strok
    SEAN PADRAIG MURPHY; Fiscal Year: 2013
    ..outcome from ischemic stroke has proved to be challenging and current treatment is limited to thrombolysis, aspirin, and management in a stroke unit...
  31. Indolecarbinol target proteins and anti-cancer signaling in human melanoma cells
    Gary L Firestone; Fiscal Year: 2013
    ..aim will characterize the anti-cancer effects in melanoma cells of combinations of indolecarbinol compounds and aspirin in both cellular and in vivo contexts...
  32. Registry Study of Parkinsons Disease in Denmark
    Beate R Ritz; Fiscal Year: 2010
    ..g. NSAIDS, aspirin, and cortisone use, or M...
  33. Diet, Activity, and Lifestyle as a Risk Factor for Colorectal Cancer
    Martha L Slattery; Fiscal Year: 2012
    ..Major factors that modify the effects of other risk factors are'use of aspirin and ibuprofen-type drugs...
  34. Disparities in Breast Cancer: Development and Survival in Hispanic and NHW Women
    Martha L Slattery; Fiscal Year: 2013
    ..Interaction of signaling pathway genes with each other and with NSAIDs, aspirin, BMI, estrogen, and physical activity will be examined...
  35. Lipoxin-Mediated Inflammatory Resolution in Newborn Hyperoxic Lung Injury
    RODNEY BRITT; Fiscal Year: 2012
    ..b>Aspirin, an anti-inflammatory drug that acetylates COX-2 and changes COX-2 function from a cyclooxygenases to a ..
  36. Prostaglandins in C. elegans Fertilization
    Michael A Miller; Fiscal Year: 2013
    ..b>Aspirin and other non-steroidal anti- inflammatory drugs (NSAIDs) specifically inhibit prostaglandin synthesis and are ..
  37. Formation of Omega 3-Derived Electrophiles During Inflammation
    FRANCISCO JOSE SCHOPFER; Fiscal Year: 2013
    ..The formation of these species was dependent on COX-2, and administered aspirin increased the levels of these w-3 electrophilic fatty acid oxo-derivatives (EFOX)...
  38. Prasugrel for prevention of early saphenous vein graft thrombosis
    Emmanouil Brilakis; Fiscal Year: 2013
    ..b>Aspirin significantly reduces the incidence of early saphenous vein graft failure, whereas clopidogrel use provided ..
  39. Novel Antithrombotic Diadenosine Tetraphosphate Analogs
    IVAN B YANACHKOV; Fiscal Year: 2010
    ..b>Aspirin and clopidrogel (Plavix(R), $5.9B sales in 2005) are the most popular of the class today...
  40. Selenium Colorectal Cancer Chemoprevention Trials
    PATRICIA ANN THOMPSON; Fiscal Year: 2013
    ..In secondary analyses, we will investigate whether or not baseline Se levels, genetic background, and/or use of low-dose aspirin modify Se effects on CRA occurrence or risk for T2D.
  41. Interplay between LTE4/LTE4 receptors and IFN-y with mast cells and eosinophils i
    Larry C Borish; Fiscal Year: 2013
    ..These studies will focus on cellular and immune mechanisms of asthma (and sinusitis) as they pertain to aspirin-exacerbated respiratory disease (AERD)...
  42. Role of IRF3 and RXRa Crosstalk in Host Response to Viral Infections
    Genhong Cheng; Fiscal Year: 2013
    ..metabolic diseases such as Reye's Syndrome, a hepatotoxicity disease that occurs when children are given aspirin in the context of a viral infection, or acetaminophen (APAP)-induced hepatotoxicity, which accounts for about ..
  43. ASPirin in Reducing Events in the Elderly
    JOHN JAMES MCNEIL; Fiscal Year: 2013
    This Application seeks funding for a randomized double-blind placebo-controlled trial of aspirin in primary prevention in healthy elderly people aged 70 years and over...
  44. Therapeutic factor XI blockade for sepsis
    ERIK IAN contact TUCKER; Fiscal Year: 2010
    ..by antibody inhibition of FXI is antithrombotic for more than a week, and hemostatically safer than heparin or aspirin. No comparable drugs exist, and thus if AXIMAB is successfully developed, it would have significant market ..
  45. Model of Platelet Adhesion and Thrombus Formation
    Michael R King; Fiscal Year: 2013
    ..The simulation will be first applied to the clinical investigation and diagnosis of hereditary bleeding disorders, and in the future will enable phenotype prediction of patients treated with anticoagulants such as aspirin and Plavix.
  46. Metabolomics Network for Drug Response Phenotype
    RIMA F KADDURAH DAOUK; Fiscal Year: 2010
    ..drugs: antihypertensives (atenolol and hydrochlorothiazide ) and antiplatelet therapies (clopidogrel and aspirin)...
  47. Development of Headwear To Prevent Fall-Related Injuries in Elderly Persons
    JAMES RIDDELL FERGUSON; Fiscal Year: 2011
    ..Some of the increase incidence in and mortality from TBI is associated with anticoagulation therapy, including aspirin and the 2 million new users of warfarin each year12...
  48. Studies of Eicosanoid Biosynthetic Proteins
    Wonhwa Cho; Fiscal Year: 2013
    ..It has been well documented that the eicosanoid biosynthetic system offers many important drug targets (e.g., aspirin and other non-steroidal anti-inflammatory drugs targeted to COXs);however, inhibition of an individual component ..
  49. Effect of Statins and Modifiable Factors on Stroke Outcome in Atrial Fibrillation
    Elaine Hylek; Fiscal Year: 2012
    ..Despite their greater burden of risk factors, minorities have constituted less than 5% of AF trial populations. Aspirin is a marginally effective therapy in AF and causes bleeding almost as frequently as anticoagulants, particularly ..
  50. Aspirin, PPAR and EAE
    Kalipada Pahan; Fiscal Year: 2013
    ..Is it really possible? Our preliminary results show that it is possible with aspirin, acetylsalicylic acid, one f the most widely-used analgesics throughout the world...
  51. Functional Genomics of Platelet Aggregation Using iPS and Derived Megakaryocytes
    Linzhao Cheng; Fiscal Year: 2013
    ..In our GWAS study of native platelet aggregation and aggregation in response to low dose aspirin (GeneSTAR, Genetic Study of Aspirin Responsiveness), 64 loci were associated with native platelet aggregation at ..
  52. Molecular Epidemiology of NHL and CLL
    James R Cerhan; Fiscal Year: 2012
    ..with risk of NHL;2) To evaluate epidemiologic risk factors for NHL, with a focus on medical history (including aspirin and NSAID use, immunization history, and statin use), energy balance (including obesity and physical activity), ..
  53. Multi-factorial Intervention to Slow Progression of Diabetic Kidney Disease
    Uptal D Patel; Fiscal Year: 2013
    ..medication adherence, diet, physical activity, weight control), and cardiovascular risks (lipid profiles, aspirin use, smoking cessation). We will also conduct cost-effectiveness analyses using a robust simulation model...
  54. Biobehavioral Bases &Management of Type 2 Diabetes and Depression
    Neil Schneiderman; Fiscal Year: 2011
    ..As many of the participants will already have been prescribed aspirin, statins, oral hypoglycemics and other medications, an important objective of the project will be to assess the ..
  55. Pathways and pathogens affecting gastric epithelial repair in vivo
    Marshall H Montrose; Fiscal Year: 2013
    ..the presence of the stomach pathogen Helicobacter pylori or the toxicity of ingested therapeutic drugs (such as aspirin, or the bisphosphonate drugs used to treat osteoporosis)...
  56. Chemopreventive Effect of NSAIDs Against Prostate Cancer
    Bhagavathi Narayanan; Fiscal Year: 2009
    ..Epidemiological studies suggest that regular use of non-steroidal antiinflammatory drugs (NSAIDs), including aspirin, might be as protective against prostate cancer as it is against colon cancer, although NSAIDs may have some side ..
  57. Dynamic regulation of salicylic acid biosynthesis &perception in plant immunity
    Xinnian Dong; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Salicylic acid (SA) and derivatives, such as aspirin, have a long list of medicinal effects, which include not only fever reduction and pain relief, but also prevention of cardiovascular diseases and ..
  58. Mechanisms of normal and abnormal platelet homeostasis
    Joel S Bennett; Fiscal Year: 2010
    ..Project 3, entitled "Clinical aspects of aspirin and clopidogrel resistance", addresses the stability, specificity and incidence of the "aspirin resistant" ..
  59. Stents and Antiplatelet Drugs: Impact on Ischemia and Bleeding in the Elderly
    Samip Vasaiwala; Fiscal Year: 2011
    ..Placement of either type of stent requires treatment with clot- preventing medications such as aspirin and clopidogrel or prasugrel to keep them open...
  60. Impact of Health IT Implementation on Diabetes Process and Outcome Measures
    David J Ballard; Fiscal Year: 2012
    ..Diabetes Care" composite measure (HbA1c <8%;LDL cholesterol <100 mg/dL;Blood pressure <130/80 mmHg;Aspirin prescription in patients e40 years;and, Not smoking)...
  61. BLOOD CELL LIPOXYGENASE PRODUCTS--FORMATION AND ACTION
    CHARLES NICHOLAS SERHAN; Fiscal Year: 2013
    ..The genus includes resolvins (Rv), protectins (PD) and their aspirin-triggered (AT) forms biosynthesized from essential omega-3 fatty acids (n-3 EFA)...
  62. Targeting Leukemia Stem Cells with Dietary Selenium
    KUMBLE SANDEEP PRABHU; Fiscal Year: 2013
    ..serum Se levels in leukemia patients as well as higher incidences of adult leukemia in individuals consuming non-aspirin analgesics, our long- term goal is to understand if Se supplementation of leukemia patients would be beneficial.
  63. PREVENTION OF ULCER HEMORRHAGE BY H PYLORI ERADICATION
    Dennis Jensen; Fiscal Year: 2000
    ..pylori eradication plus full-dose H2RA maintenance in preventing recurrent ulcer hemorrhage and 2) ingestion of aspirin (ASA) or other non-steroidal anti-inflammatory drugs (NSAIDs) or recurrence of H...
  64. RISK SCORE FOR CORONARY ANEURYSMS IN KAWASAKI SYNDROME
    Jane Newburger; Fiscal Year: 1992
    ..Treatment with intravenous gamma globulin and aspirin with the first 10 days of illness has been demonstrated to reduce the prevalence of coronary lesions...
  65. IN VIVO INHIBITORS OF OCULAR PROSTAGLANDIN SYNTHESIS
    STEVEN PODOS; Fiscal Year: 1980
    The synthesis of prostaglandins occurs in the eye. Aspirin-like compounds inhibit prostaglandin synthesis. A differential sensitivity of the prostaglandin synthetase system exists in different tissues...
  66. MOLECULAR MECHANISMS OF ASPIRIN IN CANCER PREVENTION
    Zigang Dong; Fiscal Year: 2001
    b>Aspirin is one of the most promising agents for the chemoprevention of human cancer. The clinical usefulness of aspirin is partially limited by its side effects...
  67. Aspirin, Helicobacter Pylori, and Peptic Ulcer Disease
    Edward Lew; Fiscal Year: 2003
    b>Aspirin and other non-steroidal anti-inflammatory drugs are widely used to treat pain and inflammation, and at low doses, aspirin is also increasingly being used for cardiovascular prophylaxis...
  68. RANDOMIZED TRIALS OF VITAMIN SUPPLEMENTS AND EYE DISEASE
    William Christen; Fiscal Year: 2002
    ..The PHS is a randomized, double-blind, placebo-controlled trial of aspirin use in reducing cardiovascular disease, and beta-carotene in reducing cancer, among 22,071 male U.S...
  69. POLYMORPHISMS IN PG/COX PATHWAY AND COLORECTAL POLYPS
    Cornelia Ulrich; Fiscal Year: 2003
    b>Aspirin and other non-steroidal inflammatory drugs (NSAIDs) reduce the recurrence of colorectal polyps among patients with familial adenomatous polyposis (FAP) and are associated with a lower risk of both adenoma and colorectal cancer...
  70. GENE-ENVIRONMENT EFFECTS AND COLON ADENOMAS
    Henry Lin; Fiscal Year: 2000
    ..Environmental exposures to be analyzed include: meat, cruciferous vegetables, and aspirin. High meat diets are believed to be risk factors, whereas cruciferous vegetables and aspirin are believed to be ..
  71. TRIAL OF ASPIRIN AND VITAMIN E IN WOMEN
    Julie Buring; Fiscal Year: 2000
    ..an ongoing randomized, double-blind, placebo-controlled trial evaluating the benefits and risks of low-dose aspirin (100 mg on alternate days), vitamin E (600 IU on alternate days), and beta-carotene (50 mg on alternate days) ina ..
  72. Analgesic Use and Kidney Cancer
    Eunyoung Cho; Fiscal Year: 2009
    ..The NSAID aspirin is one of the most commonly used drugs in the U.S...
  73. ANALGESIC USE AND THE RISK OF CHRONIC RENAL FAILURE
    Gary Curhan; Fiscal Year: 2002
    ..with consumption of large amounts of acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) but not aspirin. Since these analgesics are widely available and used, their association with renal dysfunction is particularly ..
  74. ASPIRIN'S FIBRINOLYTIC EFFECT--ACETYLATION OF FIBRINOGEN
    Thorir Bjornsson; Fiscal Year: 1992
    b>Aspirin therapy has been associated with significant clinical antithrombotic effects in certain arterial thromboembolic disorders, particularly for the treatment of transient ischemic attacks and unstable angina, and for the secondary ..