Genomes and Genes
Summary: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
Publications340 found, 100 shown here
- Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trialsColin Baigent
CTSU, Oxford University, Oxford, UK
Lancet 373:1849-60. 2009Low-dose aspirin is of definite and substantial net benefit for many people who already have occlusive vascular disease. We have assessed the benefits and risks in primary prevention.
- Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trialsPeter M Rothwell
Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, Oxford, UK
Lancet 377:31-41. 2011Treatment with daily aspirin for 5 years or longer reduces subsequent risk of colorectal cancer...
- Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signalsCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Exp Med 196:1025-37. 2002b>Aspirin (ASA) is unique among current therapies because it acetylates cyclooxygenase (COX)-2 enabling the biosynthesis of R-containing precursors of endogenous antiinflammatory mediators...
- Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): a randomised controlled trialJonathan Mant
Primary Care Clinical Sciences, University of Birmingham, Birmingham, UK
Lancet 370:493-503. 2007..We assessed whether warfarin reduced risk of major stroke, arterial embolism, or other intracranial haemorrhage compared with aspirin in elderly patients.
- Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trialsPeter M Rothwell
Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK
Lancet 379:1602-12. 2012Daily aspirin reduces the long-term risk of death due to cancer...
- Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trialS Connolly
Health Research Institute, Hamilton, ON, Canada
Lancet 367:1903-12. 2006..However, long-term monitoring is necessary and many patients cannot achieve optimum anticoagulation. We assessed whether clopidogrel plus aspirin was non-inferior to oral anticoagulation therapy for prevention of vascular events.
- Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivationYee Ping Sun
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 282:9323-34. 2007..stereochemistry of the conjugated double bonds and chirality of alcohols present in resolvin D1 (RvD1) and its aspirin-triggered 17R epimer (AT-RvD1) with compounds prepared by total organic synthesis...
- Aspirin intake and survival after breast cancerMichelle D Holmes
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Clin Oncol 28:1467-72. 2010Animal and in vitro studies suggest that aspirin may inhibit breast cancer metastasis. We studied whether aspirin use among women with breast cancer decreased their risk of death from breast cancer.
- Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trialsPeter M Rothwell
Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK
Lancet 379:1591-601. 2012Daily aspirin reduces the long-term incidence of some adenocarcinomas, but effects on mortality due to some cancers appear after only a few years, suggesting that it might also reduce growth or metastasis...
- Clopidogrel with or without omeprazole in coronary artery diseaseDeepak L Bhatt
Veterans AffairsBoston Healthcare System, Brigham and Women s Hospital, Boston, MA 02132, USA
N Engl J Med 363:1909-17. 2010..Recently, concerns have been raised about the potential for PPIs to blunt the efficacy of clopidogrel...
- Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptorMauro Perretti
1 Department of Biochemical Pharmacology, William Harvey Research Institute, Bart s and the London School of Medicine, Queen Mary University of London, Charterhouse Square, London, UK 2 M P and N C contributed equally to this paper
Nat Med 8:1296-302. 2002b>Aspirin (ASA) and dexamethasone (DEX) are widely used anti-inflammatory agents yet their mechanism(s) for blocking polymorphonuclear neutrophil (PMN) accumulation at sites of inflammation remains unclear...
- Aspirin and cancer risk: a quantitative review to 2011C Bosetti
Department of Epidemiology, Istituto di Ricerche Farmacologiche, Mario Negri, Milan, Italy
Ann Oncol 23:1403-15. 2012b>Aspirin has been associated to a reduced risk of colorectal and possibly of a few other common cancers.
- Acetylsalicylic acid-induced oxidative stress, cell cycle arrest, apoptosis and mitochondrial dysfunction in human hepatoma HepG2 cellsHaider Raza
Department of Biochemistry, Faculty of Medicine and Health Sciences, UAE University, POBox 17666, Al Ain, United Arab Emirates
Eur J Pharmacol 668:15-24. 2011It is widely accepted that non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin, reduce the risk of cancer...
- Aspirin for primary prevention of cardiovascular events in people with diabetes: meta-analysis of randomised controlled trialsGiorgia De Berardis
Department of Clinical Pharmacology and Epidemiology, Consorzio Mario Negri Sud, Via Nazionale 8 A, 66030 S Maria Imbaro, Italy
BMJ 339:b4531. 2009To evaluate the benefits and harms of low dose aspirin in people with diabetes and no cardiovascular disease.
- Aspirin and cancer: has aspirin been overlooked as an adjuvant therapy?R E Langley
MRC Clinical Trials Unit, London, UK
Br J Cancer 105:1107-13. 2011b>Aspirin inhibits the enzyme cyclooxygenase (Cox), and there is a significant body of epidemiological evidence demonstrating that regular aspirin use is associated with a decreased incidence of developing cancer...
- Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survivalXiaoyun Liao
Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA
N Engl J Med 367:1596-606. 2012Regular use of aspirin after a diagnosis of colon cancer has been associated with a superior clinical outcome...
- Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cellsFarhat V N Din
Colon Cancer Genetics Group and Academic Coloproctology, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council Human Genetics Unit, Western General Hospital Edinburgh, United Kingdom
Gastroenterology 142:1504-15.e3. 2012b>Aspirin reduces the incidence of and mortality from colorectal cancer (CRC) by unknown mechanisms. Cancer cells have defects in signaling via the mechanistic target of rapamycin (mTOR), which regulates proliferation...
- Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statementJack Cuzick
Cancer Research UK Centre for Epidemiology, Mathematics, and Statistics, Queen Mary University of London, London UK
Lancet Oncol 10:501-7. 2009Evidence clearly shows a chemopreventive effect for aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) on colorectal cancer and probably other cancer types; however, data on the risk-benefit profile for cancer prevention ..
- Low-dose aspirin for primary prevention of atherosclerotic events in patients with type 2 diabetes: a randomized controlled trialHisao Ogawa
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto City, 860 8556, Japan
JAMA 300:2134-41. 2008Previous trials have investigated the effects of low-dose aspirin on primary prevention of cardiovascular events, but not in patients with type 2 diabetes.
- Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: an overview of their protective roles in catabasisCharles N Serhan
Department of Anesthesiology, Perioperative and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Prostaglandins Other Lipid Mediat 73:155-72. 2004..b>Aspirin treatment impacts biosynthesis of these compounds and a related series by triggering endogenous formation of the ..
- Stroke with intermittent atrial fibrillation: incidence and predictors during aspirin therapy. Stroke Prevention in Atrial Fibrillation InvestigatorsR G Hart
Department of Medicine, University of Texas Health Science Center, San Antonio 78284, USA
J Am Coll Cardiol 35:183-7. 2000..This study was performed to characterize the risk of stroke in elderly patients with recurrent intermittent atrial fibrillation (AF)...
- Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statinsMatthew Spite
Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Circ Res 107:1170-84. 2010..Here, we overview and update the biosynthesis and actions of proresolving lipid mediators, highlighting their diverse protective roles relevant to vascular systems and their relation to aspirin and statin therapies.
- Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trialsPeter M Rothwell
Stroke Prevention Research Unit, Department of Clinical Neurology, University of Oxford, Oxford, UK
Lancet 376:1741-50. 2010High-dose aspirin (≥500 mg daily) reduces long-term incidence of colorectal cancer, but adverse effects might limit its potential for long-term prevention. The long-term effectiveness of lower doses (75-300 mg daily) is unknown...
- Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trialsAnnemijn M Algra
Stroke Prevention Research Unit, University Department of Clinical Neurology, University of Oxford, Oxford, UK
Lancet Oncol 13:518-27. 2012Long-term follow-up of randomised trials of aspirin in prevention of vascular events showed that daily aspirin reduced the incidence of colorectal cancer and several other cancers and reduced metastasis...
- Reduced expression of COXs and production of prostaglandin E(2) in patients with nasal polyps with or without aspirin-intolerant asthmaJordi Roca-Ferrer
Immunoallergia Respiratoria Clinica i Experimental, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
J Allergy Clin Immunol 128:66-72.e1. 2011Researchers have debated whether regulation of the COX enzymes (COX-1 and COX-2), which mediate production of prostaglandins (PGs), affects the pathogenesis of nasal polyps (NPs) and aspirin-intolerant asthma (AIA).
- Interindividual variability in the response to oral antiplatelet drugs: a position paper of the Working Group on antiplatelet drugs resistance appointed by the Section of Cardiovascular Interventions of the Polish Cardiac Society, endorsed by the Working Wiktor Kuliczkowski
3rd Department of Cardiology, Silesian Center for Heart Diseases, Zabrze, Poland
Eur Heart J 30:426-35. 2009..The efficacy of acetylsalicylic acid (ASA, aspirin) and clopidogrel in decreasing the risk of adverse events in coronary heart disease patients has been well ..
- Risk of bleeding with single, dual, or triple therapy with warfarin, aspirin, and clopidogrel in patients with atrial fibrillationMorten L Hansen
Department of Cardiology, Copenhagen University Hospital Gentofte, Niels Andersens Vej 65 2900, Hellerup, Copenhagen, Denmark
Arch Intern Med 170:1433-41. 2010..Patients with atrial fibrillation (AF) often require anticoagulation and platelet inhibition, but data are limited on the bleeding risk of combination therapy...
- A new combined test with flowcytometric basophil activation and determination of sulfidoleukotrienes is useful for in vitro diagnosis of hypersensitivity to aspirin and other nonsteroidal anti-inflammatory drugsM L Sanz
Department of Allergology and Clinical Immunology, University of Navarra, Pamplona, Spain
Int Arch Allergy Immunol 136:58-72. 2005..We assessed whether nonsteroidal anti-inflammatory drugs (NSAIDs) may provoke blood basophil activation in vitro in aspirin- and NSAID-hypersensitive patients, as detected by a flowcytometric technique using the CD63 marker--..
- Prevention of preeclampsia and intrauterine growth restriction with aspirin started in early pregnancy: a meta-analysisEmmanuel Bujold
Department of Obstetrics and Gynecology, Faculty of Medicine, Laval University, Quebec, Canada
Obstet Gynecol 116:402-14. 2010To estimate the effect of low-dose aspirin started in early pregnancy on the incidence of preeclampsia and intrauterine growth restriction (IUGR).
- Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trialJohn Burn
Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK
Lancet 378:2081-7. 2011Observational studies report reduced colorectal cancer in regular aspirin consumers. Randomised controlled trials have shown reduced risk of adenomas but none have employed prevention of colorectal cancer as a primary endpoint...
- Effects of low-dose aspirin on acute inflammatory responses in humansThea Morris
Division of Medicine, University College London, Centre for Clinical Pharmacology and Therapeutics, London, United Kingdom
J Immunol 183:2089-96. 2009b>Aspirin is a unique nonsteroidal anti-inflammatory drug; at high doses (aspirin(high), 1g), it is anti-inflammatory stemming from the inhibition of cyclooxygenase and proinflammatory signaling pathways including NF-kappaB, but is ..
- Randomized double-blind assessment of the ONSET and OFFSET of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease: the ONSET/OFFSET studyPaul A Gurbel
Sinai Center for Thrombosis Research, Cardiac Catheterization Laboratory, 2401 W Belvedere Ave, Baltimore, MD 21215, USA
Circulation 120:2577-85. 2009..This is the first study to compare the onset and offset of platelet inhibition (IPA) with ticagrelor using the PLATO (PLATelet inhibition and patient Outcomes) trial loading dose (180 mg) with a high loading dose (600 mg) of clopidogrel...
- Platelet function profiles in patients with type 2 diabetes and coronary artery disease on combined aspirin and clopidogrel treatmentDominick J Angiolillo
Division of Cardiology, University of Florida, Shands Jacksonville, 655 West 8th St, Jacksonville, FL 32209, USA
Diabetes 54:2430-5. 2005To assess platelet function profiles in diabetic and nondiabetic patients on aspirin and clopidogrel therapy, two patient populations were included to investigate the 1) acute effects of a 300-mg clopidogrel loading dose (group 1, n = 52)..
- EAACI/GA2LEN guideline: aspirin provocation tests for diagnosis of aspirin hypersensitivityE Nizankowska-Mogilnicka
Department of Medicine, Jagiellonian University School of Medicine, Krakow, Poland
Allergy 62:1111-8. 2007b>Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most common causes of adverse drug reactions. Majority of them are of the hypersensitivity type...
- Aspirin "resistance" and risk of cardiovascular morbidity: systematic review and meta-analysisGeorge Krasopoulos
University Health Network, Division of Cardiovascular Surgery, Toronto General Hospital
BMJ 336:195-8. 2008To determine if there is a relation between aspirin "resistance" and clinical outcomes in patients with cardiovascular disease.
- Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studiesEnrico Flossmann
Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford OX2 6HE, UK
Lancet 369:1603-13. 2007Randomised trials have shown that aspirin reduces the short-term risk of recurrent colorectal adenomas in patients with a history of adenomas or cancer, but large trials have shown no effect in primary prevention of colorectal cancer ..
- Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acute respiratory distress syndromeHollis R O'Neal
Department of Medicine, Section of Pulmonary and Critical Care Medicine, Louisiana State University Health Sciences Center, Baton Rouge, LA, USA
Crit Care Med 39:1343-50. 2011..We also investigated the effect of combined prehospital use of both statins and aspirin.
- Aspirin or enoxaparin thromboprophylaxis for patients with newly diagnosed multiple myeloma treated with lenalidomideAlessandra Larocca
Myeloma Unit, Division of Hematology, University of Torino, Azienda Ospedaliero Universitaria AOU S Giovanni Battista, Torino, Italy
Blood 119:933-9; quiz 1093. 2012..randomized substudy of a phase 3 trial compared the efficacy and safety of thromboprophylaxis with low-dose aspirin (ASA) or low-molecular-weight heparin (LMWH) in patients with newly diagnosed MM, treated with lenalidomide and ..
- Effect of aspirin and NSAIDs on risk and survival from colorectal cancerFarhat V N Din
Colon Cancer Genetics Group and Academic Coloproctology, Institute of Genetics and Molecular Medicine, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK
Gut 59:1670-9. 2010Previous studies have shown that aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) lower colorectal cancer (CRC) risk. However, the lowest effective NSAID dose, treatment duration, and effects on survival are not defined...
- Dabigatran with or without concomitant aspirin compared with warfarin alone in patients with nonvalvular atrial fibrillation (PETRO Study)Michael D Ezekowitz
Lankenau Institute for Medical Research and The Heart Center, Wynnewood, PA, USA
Am J Cardiol 100:1419-26. 2007..to receive blinded doses of 50-, 150-, or 300-mg dabigatran twice daily alone or combined with 81- or 325-mg aspirin or open-label warfarin administered to achieve an international normalized ratio of 2 to 3 for 12 weeks...
- Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosisMarc I Chimowitz
Department of Neurology, School of Medicine, Emory University, Atlanta, USA
N Engl J Med 352:1305-16. 2005Atherosclerotic intracranial arterial stenosis is an important cause of stroke. Warfarin is commonly used in preference to aspirin for this disorder, but these therapies have not been compared in a randomized trial.
- Prevention of peptic ulcers with esomeprazole in patients at risk of ulcer development treated with low-dose acetylsalicylic acid: a randomised, controlled trial (OBERON)James M Scheiman
Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
Heart 97:797-802. 2011....
- Aspirin sensitizes cancer cells to TRAIL-induced apoptosis by reducing survivin levelsMeiling Lu
Cell Death Regulation Laboratory, Department of Medicine and Cell and Molecular Biology, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
Clin Cancer Res 14:3168-76. 2008..We examined whether the nonsteroidal anti-inflammatory drug aspirin sensitized cancer cells to TRAIL agonists in vitro and in vivo and investigated the underlying mechanism.
- Effect of single nucleotide polymorphisms within the interleukin-4 promoter on aspirin intolerance in asthmatics and interleukin-4 promoter activityByung Soo Kim
Division of Molecular and Life Sciences, College of Science and Technology, Hanyang University, Sangrok Ku, Ansan, Gyeonggi Do, Korea
Pharmacogenet Genomics 20:748-58. 2010b>Aspirin affects interleukin-4 (IL-4) synthesis; however, the genetic role of IL-4 has not been evaluated in asthmatics with aspirin hypersensitivity...
- Association of PTGER gene family polymorphisms with aspirin intolerant asthma in Korean asthmaticsByung Lae Park
Department of Life Science, Sogang University, Seoul, Korea
BMB Rep 43:445-9. 2010b>Aspirin-intolerant asthma (AIA) is characterized by severe asthmatic attack after ingestion of aspirin and/or non-steroidal anti-inflammatory drugs...
- The flow-cytometric determination of basophil activation induced by aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) is useful for in vitro diagnosis of the NSAID hypersensitivity syndromeP Gamboa
Allergy Unit, Hospital Basurto, Bilbao, Spain
Clin Exp Allergy 34:1448-57. 2004..Today, it is still claimed that no in vitro diagnostic tests exist for that condition and that the only way to confirm the diagnosis is a provocation challenge...
- Continuation of low-dose aspirin therapy in peptic ulcer bleeding: a randomized trialJoseph J Y Sung
Institute of Digestive Disease, Chinese University of Hong Kong, Sha Tin, New Territories, Hong Kong
Ann Intern Med 152:1-9. 2010It is uncertain whether aspirin therapy should be continued after endoscopic hemostatic therapy in patients who develop peptic ulcer bleeding while receiving low-dose aspirin.
- Anticoagulants (thrombin inhibitors) and aspirin synergize with P2Y12 receptor antagonism in thrombosisPatrick Andre
Millennium Pharmaceuticals, Inc, 256 E Grand Ave, South San Francisco, Calif 9408, USA
Circulation 108:2697-703. 2003..This study was designed to determine whether (1) P2Y12 antagonism synergizes with other antithrombotics and (2) anticoagulants (thrombin inhibitors) affect the antithrombotic activity elicited by P2Y12 antagonism...
- Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseasesT E Van Dyke
Department of Periodontology and Oral Biology, Boston University, Goldman School of Dental Medicine, 100 East Newton Street, Boston, MA 02118, USA
J Dent Res 82:82-90. 2003....
- Activation of lipoxin A(4) receptors by aspirin-triggered lipoxins and select peptides evokes ligand-specific responses in inflammationN Chiang
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Exp Med 191:1197-208. 2000Lipoxin (LX) A(4) and aspirin-triggered LX (ATL) are endogenous lipids that regulate leukocyte trafficking via specific LXA(4) receptors (ALXRs) and mediate antiinflammation and resolution...
- Prasugrel versus clopidogrel in patients with acute coronary syndromesStephen D Wiviott
Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
N Engl J Med 357:2001-15. 2007Dual-antiplatelet therapy with aspirin and a thienopyridine is a cornerstone of treatment to prevent thrombotic complications of acute coronary syndromes and percutaneous coronary intervention.
- Posttreatment with aspirin-triggered lipoxin A4 analog attenuates lipopolysaccharide-induced acute lung injury in mice: the role of heme oxygenase-1Sheng wei Jin
Department of Anesthesiology, Second Affiliated Hospital, Wenzhou Medical College, Wenzhou, China
Anesth Analg 104:369-77. 2007..We hypothesized that posttreatment with 15-epi-16-parafluoro-phenoxy lipoxin A4 (ATL) could attenuate lipopolysaccharide (LPS)-induced acute lung injury in mice...
- Clinical and pathologic perspectives on aspirin sensitivity and asthmaDonald D Stevenson
Division of Allergy, Asthma and Immunology and the Department of Medicine, Scripps Clinic and the Scripps Research Institute, La Jolla, USA
J Allergy Clin Immunol 118:773-86; quiz 787-8. 2006b>Aspirin and other nonsteroidal anti-inflammatory drugs that inhibit COX-1 induce unique nonallergic reactions, consisting of attacks of rhinitis and asthma...
- Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issuesMichael J Thun
Department of Epidemiology and Surveillance Research, American Cancer Society, National Home Office, Atlanta, GA 30329 4251, USA
J Natl Cancer Inst 94:252-66. 2002..Finally, we suggest research opportunities that may help to accelerate the future clinical application of NSAIDs for cancer prevention or treatment...
- Evaluation of dose-related effects of aspirin on platelet function: results from the Aspirin-Induced Platelet Effect (ASPECT) studyPaul A Gurbel
Sinai Center for Thrombosis Research, Hoffberger Bldg, Suite 56, 2401 W Belvedere Ave, Baltimore, MD 21215, USA
Circulation 115:3156-64. 2007The antiplatelet effect of aspirin is attributed to platelet cyclooxygenase-1 inhibition...
- Antiplatelet agents for prevention of pre-eclampsia: a meta-analysis of individual patient dataLisa M Askie
Centre for Perinatal Health Services Research, University of Sydney, Sydney, Australia
Lancet 369:1791-8. 2007..Antiplatelet agents, especially low-dose aspirin, might prevent or delay pre-eclampsia, and thereby improve outcome...
- Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trialShamir R Mehta
McMaster University and Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada
Lancet 376:1233-43. 2010Clopidogrel and aspirin are the most commonly used antiplatelet therapies for percutaneous coronary intervention (PCI)...
- Aspirin and extended-release dipyridamole versus clopidogrel for recurrent strokeRalph L Sacco
Miller School of Medicine, University of Miami, Miami, USA
N Engl J Med 359:1238-51. 2008Recurrent stroke is a frequent, disabling event after ischemic stroke. This study compared the efficacy and safety of two antiplatelet regimens--aspirin plus extended-release dipyridamole (ASA-ERDP) versus clopidogrel.
- Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependentFabiana S Machado
Department of Immunology, Duke University Medical Center, Durham, North Carolina 27705, USA
Nat Med 12:330-4. 2006Control of inflammation is crucial to prevent damage to the host during infection. Lipoxins and aspirin-triggered lipoxins are crucial modulators of proinflammatory responses; however, their intracellular mechanisms have not been ..
- Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: a double-blind comparison to clopidogrel with aspirinSteen Husted
Department of Medicine and Cardiology, Arhus University Hospital, Denmark
Eur Heart J 27:1038-47. 2006..This double-blind, parallel-group study was conducted to assess the pharmacodynamics, pharmacokinetics, and safety of AZD6140, the first oral, reversible adenosine diphosphate (ADP) receptor antagonist...
- Prevalence of asthma, aspirin intolerance, nasal polyposis and chronic obstructive pulmonary disease in a population-based studyJ Hedman
Department of Respiratory Medicine, Tampere University Hospital, Finland
Int J Epidemiol 28:717-22. 1999..The prevalence and relation to asthma of aspirin intolerance, nasal polyposis, allergic rhinitis and smoking habits were also examined.
- Leukotriene-receptor expression on nasal mucosal inflammatory cells in aspirin-sensitive rhinosinusitisAna R Sousa
Guy s, King s and St Thomas School of Medicine, London, United Kingdom
N Engl J Med 347:1493-9. 2002Patients with asthma who have aspirin sensitivity have greater cysteinyl leukotriene production and greater airway hyperresponsiveness to the effects of inhaled cysteinyl leukotrienes than their aspirin-tolerant counterparts...
- Aspirin for prevention of cardiovascular events in a general population screened for a low ankle brachial index: a randomized controlled trialF Gerald R Fowkes
Centre for Population Health Sciences, University of Edinburgh, Scotland
JAMA 303:841-8. 2010..Screening for a low ABI can identify an asymptomatic higher risk group potentially amenable to preventive treatments...
- A randomized study assessing the impact of cilostazol on platelet function profiles in patients with diabetes mellitus and coronary artery disease on dual antiplatelet therapy: results of the OPTIMUS-2 studyDominick J Angiolillo
Division of Cardiology, University of Florida College of Medicine at Shands Jacksonville, Jacksonville, FL 32209, USA
Eur Heart J 29:2202-11. 2008..The aim of this pilot study was to assess the functional impact of cilostazol in T2DM patients on standard aspirin and clopidogrel treatment.
- Aspirin dose for the prevention of cardiovascular disease: a systematic reviewCharles L Campbell
Gill Heart Institute, University of Kentucky, Lexington, USA
JAMA 297:2018-24. 2007More than 50 million US adults take aspirin regularly for long-term prevention of cardiovascular disease, typically either 81 mg/d or 325 mg/d. Controversy remains regarding the most appropriate long-term daily dose.
- Selecting patients with atrial fibrillation for anticoagulation: stroke risk stratification in patients taking aspirinBrian F Gage
Division of General Medical Sciences, Washington University School of Medicine Campus Box 8005, 660 S Euclid Ave, St Louis, MO 63110, USA
Circulation 110:2287-92. 2004..Although adjusted-dose warfarin is superior to aspirin for reducing stroke in AF, the absolute risk reduction of warfarin depends on the stroke rate with aspirin...
- A possible association of EMID2 polymorphisms with aspirin hypersensitivity in asthmaCharisse Flerida A Pasaje
Department of Life Science, Sogang University, 1 Shinsu dong, Mapo gu, Seoul, 121 742, Republic of Korea
Immunogenetics 63:13-21. 2011b>Aspirin-intolerant asthma (AIA) is an asthma phenotype characterized by the development of bronchoconstriction following ingestion of aspirin...
- Prothrombotic and hemorrhagic effects of aspirinOmar Aguejouf
Laboratoire d Hématologie Université Victor Segalen Bordeaux 2, Bordeaux, France
Clin Appl Thromb Hemost 15:523-8. 2009b>Aspirin remains the most widely used drug for prevention of vascular events...
- Modulation of thiol homeostasis induced by H2S-releasing aspirinDaniela Giustarini
Department of Evolutionary Biology, Laboratory of Pharmacology and Toxicology, University of Siena, Siena, Italy
Free Radic Biol Med 48:1263-72. 2010The H(2)S-releasing aspirin (ACS14) containing a dithiolethione moiety has been demonstrated to maintain the thromboxane-suppressing activity of the parent compound, but it seems to spare the gastric mucosa by affecting redox imbalance ..
- Aspirin with or without an antiemetic for acute migraine headaches in adultsVaro Kirthi
Pain Research and Nuffield Department of Anaesthetics, University of Oxford, West Wing Level 6, John Radcliffe Hospital, Oxford, Oxfordshire, UK, OX3 9DU
Cochrane Database Syst Rev 4:CD008041. 2010..OBJECTIVES: To determine the efficacy and tolerability of aspirin, alone or in combination with an antiemetic, compared to placebo and other active interventions in the treatment ..
- Aspirin for preventing the recurrence of venous thromboembolismCecilia Becattini
Division of Internal and Cardiovascular Medicine and Stroke Unit, Department of Internal Medicine, University of Perugia, Perugia, Italy
N Engl J Med 366:1959-67. 2012..Extending anticoagulation prevents recurrences but is associated with increased bleeding. The benefit of aspirin for the prevention of recurrent venous thromboembolism is unknown.
- Oral anticoagulants vs aspirin in nonvalvular atrial fibrillation: an individual patient meta-analysisCarl van Walraven
Clinical Epidemiology Unit, Ottawa Health Research Institute, F 6, Ottawa Hospital, Civic Campus, 1053 Carling Ave, Ottawa, Ontario, Canada K1Y 4E9
JAMA 288:2441-8. 2002..Patients with nonvalvular atrial fibrillation (AF) have an increased risk of stroke and other vascular events...
- Terutroban versus aspirin in patients with cerebral ischaemic events (PERFORM): a randomised, double-blind, parallel-group trialMarie Germaine Bousser
Hopital Lariboisiere, INSERM U, Paris Diderot University, France
Lancet 377:2013-22. 2011..We compared the selective thromboxane-prostaglandin receptor antagonist terutroban with aspirin in the prevention of cerebral and cardiovascular ischaemic events in patients with a recent non-cardioembolic ..
- The role of aspirin in cancer preventionMichael J Thun
Epidemiology Research Program, American Cancer Society, 250 Williams Street, Atlanta, GA 30303 1002, USA michael thun cancer org
Nat Rev Clin Oncol 9:259-67. 2012Clinical guidelines for prophylactic aspirin use currently only consider the cardiovascular benefits of aspirin, weighed against the potential harm from aspirin-induced bleeding...
- Early administration of low-dose aspirin for the prevention of preterm and term preeclampsia: a systematic review and meta-analysisStéphanie Roberge
Department of Social and Preventive Medicine, Universite Laval, Quebec City, Que, Canada
Fetal Diagn Ther 31:141-6. 2012To compare the effect of early administration of aspirin on the risk of preterm and term preeclampsia.
- Resolvin D1 and aspirin-triggered resolvin D1 promote resolution of allergic airways responsesAlexandre P Rogerio
Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 189:1983-91. 2012..In this study, we determined the impact of resolvin D1 (RvD1) and aspirin-triggered RvD1 (AT-RvD1) on the development of allergic airway responses and their resolution...
- Early treatment with aspirin plus extended-release dipyridamole for transient ischaemic attack or ischaemic stroke within 24 h of symptom onset (EARLY trial): a randomised, open-label, blinded-endpoint trialReinhard Dengler
Department of Neurology, Medizinische Hochschule Hannover, Hannover, Germany
Lancet Neurol 9:159-66. 2010..The EARLY trial aimed to compare outcome in patients given aspirin plus extended-release dipyridamole twice daily either within 24 h of stroke or TIA or after 7 days of aspirin ..
- Esomeprazole compared with famotidine in the prevention of upper gastrointestinal bleeding in patients with acute coronary syndrome or myocardial infarctionFook Hong Ng
Department of Medicine and Geriatric, Ruttonjee Hospital, Hong Kong, China
Am J Gastroenterol 107:389-96. 2012..in patients with acute coronary syndrome (ACS) or ST elevation myocardial infarction (STEMI) receiving aspirin, clopidogrel, and enoxaparin or thrombolytics...
- Proton pump inhibitor use and risk of adverse cardiovascular events in aspirin treated patients with first time myocardial infarction: nationwide propensity score matched studyMette Charlot
Department of Cardiology, Copenhagen University Hospital Gentofte, Post 635, Niels Andersens Vej 65, 2900 Hellerup, Denmark
BMJ 342:d2690. 2011To examine the effect of proton pump inhibitors on adverse cardiovascular events in aspirin treated patients with first time myocardial infarction.
- Aspirin, warfarin, or enoxaparin thromboprophylaxis in patients with multiple myeloma treated with thalidomide: a phase III, open-label, randomized trialAntonio Palumbo
University of Torino, Azienda Ospedaliero Universitaria San Giovanni Battista, Torino, Italy
J Clin Oncol 29:986-93. 2011..In this randomized, open-label, multicenter trial, we compared aspirin (ASA) or fixed low-dose warfarin (WAR) versus low molecular weight heparin (LMWH) for preventing thromboembolism ..
- NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and modulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenograftsKaruppaiyah Selvendiran
Davis Heart and Lung Research Institute and Comprehensive Cancer Center, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA
Cell Cycle 7:81-8. 2008We have previously reported the inhibitory effect of NCX-4016, a nitro derivative of aspirin, on the proliferation of cisplatin-resistant human ovarian cancer cells, in vitro (Bratasz et al., Proc Natl Acad Sci USA 2006; 103:3914-9)...
- Prevalence of aspirin and clopidogrel resistance among patients with and without drug-eluting stent thrombosisTina L Pinto Slottow
Division of Cardiology, Washington Hospital Center, Washington, District of Columbia, USA
Am J Cardiol 104:525-30. 2009..with a cohort of patients who had not would exhibit greater platelet reactivity and a greater prevalence of aspirin and clopidogrel resistance...
- Aspirin and recurrent intracerebral hemorrhage in cerebral amyloid angiopathyA Biffi
Department of Neurology and Hemorrhagic Stroke Research Program, Massachusetts General Hospital Stroke Research Center, Harvard Medical School, 175 Cambridge Street, Suite 300, Boston, MA 02114, USA
Neurology 75:693-8. 2010..To identify and compare clinical and neuroimaging predictors of primary lobar intracerebral hemorrhage (ICH) recurrence, assessing their relative contributions to recurrent ICH...
- Aspirin for the primary prevention of cardiovascular events in women and men: a sex-specific meta-analysis of randomized controlled trialsJeffrey S Berger
Department of Cardiovascular Medicine, Duke University, Durham, NC, USA
JAMA 295:306-13. 2006b>Aspirin therapy reduces the risk of cardiovascular disease in adults who are at increased risk. However, it is unclear if women derive the same benefit as men.
- Low-dose aspirin for prevention of stroke in low-risk patients with atrial fibrillation: Japan Atrial Fibrillation Stroke TrialHiroshi Sato
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan
Stroke 37:447-51. 2006..We examined the efficacy and safety of aspirin therapy in Japanese patients with NVAF in a prospective randomized multicenter trial.
- Low molecular weight heparin and aspirin for recurrent pregnancy loss: results from the randomized, controlled HepASA TrialCarl A Laskin
University of Toronto and LifeQuest Centre for Reproductive Medicine, Toronto, Canada
J Rheumatol 36:279-87. 2009..loss (RPL) and either autoantibodies or a coagulation abnormality, treated with low molecular weight heparin plus aspirin (LMWH/ASA) or ASA alone, and to place our results in context with other randomized clinical trials (RCT) with ..
- Effect of in vitro aspirin stimulation on basophils in patients with aspirin-exacerbated respiratory diseaseG E Celik
Ankara University School of Medicine, Division of Allergy, Ankara, Turkey
Clin Exp Allergy 39:1522-31. 2009Basophil activation has been implicated in the pathogenesis of aspirin-exacerbated respiratory disease (AERD)...
- Association of SLC6A12 variants with aspirin-intolerant asthma in a Korean populationCharisse Flerida A Pasaje
Department of Life Science, Sogang University, Seoul, 121 742, Republic of Korea
Ann Hum Genet 74:326-34. 2010b>Aspirin-intolerant asthma (AIA) occurs from asthma exacerbation after exposure to aspirin. However, the underlying mechanisms of AIA occurrence are still unclear...
- The effect of aspirin desensitization on novel biomarkers in aspirin-exacerbated respiratory diseasesRohit K Katial
Division of Allergy and Immunology, National Jewish Health, Denver, CO 80206, USA
J Allergy Clin Immunol 126:738-44. 2010Patients with aspirin-exacerbated respiratory disease have been shown to benefit clinically from aspirin desensitization followed by chronic high-dose aspirin therapy. However, the mechanism of this phenomenon is still unclear.
- Duration of dual antiplatelet therapy after implantation of drug-eluting stentsSeung Jung Park
Department of Cardiology, Center for Medical Research and Information, University of Ulsan College of Medicine, Seoul, South Korea
N Engl J Med 362:1374-82. 2010..The potential benefits and risks of the use of dual antiplatelet therapy beyond a 12-month period in patients receiving drug-eluting stents have not been clearly established...
- Platelet inhibition by aspirin 81 and 325 mg/day in men versus women without clinically apparent cardiovascular diseaseRehan Qayyum
Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Cardiol 101:1359-63. 2008Compared with men, women have greater platelet aggregation before and after low-dose aspirin. It is not known whether high-dose aspirin therapy brings residual platelet aggregation in women closer to that in men...
- Incidence and clinical impact of dual nonresponsiveness to aspirin and clopidogrel in patients with drug-eluting stentsAnna Maria Gori
Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
J Am Coll Cardiol 52:734-9. 2008This study sought to determine the incidence of aspirin nonresponsiveness in addition to clopidogrel nonresponsiveness and whether this association identifies patients at an increased risk of drug-eluting stent (DES) thrombosis.
- Interaction of inflammation, thrombosis, aspirin and enoxaparin in CNS experimental antiphospholipid syndromeDavid Tanne
Department of Neurology, Sheba Medical Center, Tel Hashomer, Israel Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, Israel
Neurobiol Dis 30:56-64. 2008..eAPS) or adjuvant (controls) and treated daily from 1 month after immunization with either sham injections, aspirin (1.2 mg/kg) or enoxaparin (1 mg/kg) for 3 months...
- Effect of platelet turnover on whole blood platelet aggregation in patients with coronary artery diseaseE L Grove
Departments ofCardiology Clinical Biochemistry, Aarhus University Hospital, Skejby, Aarhus, Denmark
J Thromb Haemost 9:185-91. 2011Previous studies have demonstrated considerable variation in the antiplatelet effect of aspirin.
- Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndromeJohn Burn
Institute of Human Genetics, Newcastle University, International Centre for Life, Central Pkwy, Newcastle upon Tyne NE1 3BZ, United Kingdom
N Engl J Med 359:2567-78. 2008Observational and epidemiologic data indicate that the use of aspirin reduces the risk of colorectal neoplasia; however, the effects of aspirin in the Lynch syndrome (hereditary nonpolyposis colon cancer) are not known...
- Current use of aspirin and antithrombotic agents in the United States among outpatients with atherothrombotic disease (from the REduction of Atherothrombosis for Continued Health [REACH] Registry)Christopher P Cannon
TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Am J Cardiol 105:445-52. 2010Despite its proven efficacy, low cost, and wide availability, aspirin remains underused. We examined current aspirin use and determined factors that influence its use among outpatients in the United States (US)...
- Effect of statin drugs and aspirin on progression in open-angle glaucoma suspects using confocal scanning laser ophthalmoscopyDawn K De Castro
Department of Ophthalmology, University of California at San Francisco, San Francisco, California 94143 0730, USA
Clin Experiment Ophthalmol 35:506-13. 2007To determine the effect of statins and aspirin on the rate of progression of optic nerve parameters in open-angle glaucoma (OAG) suspects, as defined by confocal scanning laser ophthalmoscopy (CSLO).
- Aspirin induces gastric epithelial barrier dysfunction by activating p38 MAPK via claudin-7Tadayuki Oshima
Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Am J Physiol Cell Physiol 295:C800-6. 2008..However, the mechanism by which aspirin affects the function of gastric epithelial tight junctions is unknown...
- First analysis of the relation between CYP2C19 genotype and pharmacodynamics in patients treated with ticagrelor versus clopidogrel: the ONSET/OFFSET and RESPOND genotype studiesUdaya S Tantry
Sinai Center for Thrombosis Research, Cardiac Catheterization Laboratory, 2401 W Belvedere Ave, Baltimore, MD 21215, USA
Circ Cardiovasc Genet 3:556-66. 2010..The influence of cytochrome P450 (CYP) 2C19 genotype on platelet function in patients treated with ticagrelor versus clopidogrel is unknown...
- Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NF-kappa B and AP-1 activation, and IL-8 gene expression in human leukocytesLevente Jozsef
Research Center, Maisonneuve Rosemont Hospital and Department of Medicine, University of Montreal, Montreal, QC, Canada H1T 2M4
Proc Natl Acad Sci U S A 99:13266-71. 2002Lipoxin A(4) (LXA(4)) and aspirin-triggered 15-epi-LXA(4) (ATL) are emerging as endogenous braking signals for neutrophil-mediated tissue injury...
- A randomised controlled trial of warfarin versus aspirin for stroke prevention in octogenarians with atrial fibrillation (WASPO)Amar Rash
Northern General Hospital, Medicine for the Elderly, Sheffield, UK
Age Ageing 36:151-6. 2007..Although trials demonstrate reductions in stroke with warfarin, audit data show that it is still underused. However, anti-coagulation in the very elderly is not without risk...
- Novel mechanisms by which aspirin might protect against atherosclerosisSampath Parthasarathy; Fiscal Year: 2010b>Aspirin ('acetylsalicylic acid') inhibits the formation of prostaglandins (PGs) that cause inflammation, swelling, pain and fever...
- A Clinical Trial of Aspirin and Simvastatin in Pulmonary Arterial HypertensionSteven Kawut; Fiscal Year: 2007..HMG-CoA reductase inhibitors (statins) and aspirin are very safe, highly-effective cardiovascular therapies used by millions of people...
- Aspirin and Simvastatin--Pulmonary Arterial HypertensionSteven Kawut; Fiscal Year: 2006..HMG-CoA reductase inhibitors (statins) and aspirin are very safe, highly-effective cardiovascular therapies used by millions of people...
- A Clinical Trial of Aspirin and Simvastatin in Pulmonary Arterial HypertensionSteven Kawut; Fiscal Year: 2009..HMG-CoA reductase inhibitors (statins) and aspirin are very safe, highly-effective cardiovascular therapies used by millions of people...
- Role of IRF3 and RXRa Crosstalk in Host Response to Viral InfectionsGenhong Cheng; Fiscal Year: 2010..metabolic diseases such as Reye's Syndrome, a hepatotoxicity disease that occurs when children are given aspirin in the context of a viral infection, or acetaminophen (APAP)-induced hepatotoxicity, which accounts for about ..
- Aspirin, Helicobacter Pylori, and Peptic Ulcer DiseaseEdward Lew; Fiscal Year: 2003b>Aspirin and other non-steroidal anti-inflammatory drugs are widely used to treat pain and inflammation, and at low doses, aspirin is also increasingly being used for cardiovascular prophylaxis...
- RANDOMIZED TRIALS OF VITAMIN SUPPLEMENTS AND EYE DISEASEWilliam Christen; Fiscal Year: 2002..The PHS is a randomized, double-blind, placebo-controlled trial of aspirin use in reducing cardiovascular disease, and beta-carotene in reducing cancer, among 22,071 male U.S...
- RANDOMIZED TRIALS OF VITAMIN SUPPLEMENTS AND EYE DISEASEWilliam Christen; Fiscal Year: 1993..The PHS is a randomized, double-blind, placebo-controlled trial of aspirin use in reducing cardiovascular disease, and beta-carotene in reducing cancer, among 22,071 male U.S...
- POLYMORPHISMS IN PG/COX PATHWAY AND COLORECTAL POLYPSCornelia Ulrich; Fiscal Year: 2003b>Aspirin and other non-steroidal inflammatory drugs (NSAIDs) reduce the recurrence of colorectal polyps among patients with familial adenomatous polyposis (FAP) and are associated with a lower risk of both adenoma and colorectal cancer...
- NO Releasing Aspirin and Colon Cancer ChemopreventionBasil Rigas; Fiscal Year: 2003..Current evidence suggests that they are much safer than traditional NSAIDs. Early studies indicate that an NO-aspirin (NO-ASA) derivative is much more effective than ASA in cultured cells and against colon preneoplastic lesions...
- NO Releasing Aspirin and Colon Cancer ChemopreventionBasil Rigas; Fiscal Year: 2005..Current evidence suggests that they are much safer than traditional NSAIDs. Early studies indicate that an NO-aspirin (NO-ASA) derivative is much more effective than ASA in cultured cells and against colon preneoplastic lesions...
- ANALGESIC USE AND THE RISK OF CHRONIC RENAL FAILUREGary Curhan; Fiscal Year: 2002..with consumption of large amounts of acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) but not aspirin. Since these analgesics are widely available and used, their association with renal dysfunction is particularly ..