phenols

Summary

Top Publications

  1. ncbi Antioxidant activity of plant extracts containing phenolic compounds
    M P Kähkönen
    Department of Applied Chemistry, Division of Food Chemistry, University of Helsinki, FIN 00014, Helsinki, Finland
    J Agric Food Chem 47:3954-62. 1999
  2. ncbi Human exposure to bisphenol A (BPA)
    Laura N Vandenberg
    Tufts University School of Medicine, Sackler School of Graduate Biomedical Sciences, 136 Harrison Avenue, Boston, MA 02111, USA
    Reprod Toxicol 24:139-77. 2007
  3. ncbi Polyphenols: food sources and bioavailability
    Claudine Manach
    Unité des Maladies Métaboliques et Micronutriments, INRA, 63122 Saint Genes Champanelle, France
    Am J Clin Nutr 79:727-47. 2004
  4. pmc Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Environ Health Perspect 116:39-44. 2008
  5. ncbi Association between urinary bisphenol A concentration and obesity prevalence in children and adolescents
    Leonardo Trasande
    Department of Pediatrics, New York University School of Medicine, New York, NY 10016, USA
    JAMA 308:1113-21. 2012
  6. ncbi The chemistry behind antioxidant capacity assays
    Dejian Huang
    Food Science and Technology Program, Department of Chemistry, National University of Singapore, Singapore 117543, Singapore
    J Agric Food Chem 53:1841-56. 2005
  7. pmc Urinary, circulating, and tissue biomonitoring studies indicate widespread exposure to bisphenol A
    Laura N Vandenberg
    Tufts Center for Regenerative and Developmental Biology, Tufts University, Medford, Massachusetts, USA
    Environ Health Perspect 118:1055-70. 2010
  8. pmc Exposure to phthalates and phenols during pregnancy and offspring size at birth
    Claire Philippat
    Institut National de la Sante et de la Recherche Medicale, Institut Albert Bonniot U823, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Grenoble, France
    Environ Health Perspect 120:464-70. 2012
  9. ncbi Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults
    Iain A Lang
    Epidemiology and Public Health Group, Peninsula Medical School, Barrack Rd, Exeter EX2 5DW, UK
    JAMA 300:1303-10. 2008
  10. pmc Perinatal exposure to environmentally relevant levels of bisphenol A decreases fertility and fecundity in CD-1 mice
    Nicolas J Cabaton
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Environ Health Perspect 119:547-52. 2011

Detail Information

Publications271 found, 100 shown here

  1. ncbi Antioxidant activity of plant extracts containing phenolic compounds
    M P Kähkönen
    Department of Applied Chemistry, Division of Food Chemistry, University of Helsinki, FIN 00014, Helsinki, Finland
    J Agric Food Chem 47:3954-62. 1999
    ..In addition, potato peel and beetroot peel extracts showed strong antioxidant effects. To utilize these significant sources of natural antioxidants, further characterization of the phenolic composition is needed...
  2. ncbi Human exposure to bisphenol A (BPA)
    Laura N Vandenberg
    Tufts University School of Medicine, Sackler School of Graduate Biomedical Sciences, 136 Harrison Avenue, Boston, MA 02111, USA
    Reprod Toxicol 24:139-77. 2007
    ..The reported levels of BPA in human fluids are higher than the BPA concentrations reported to stimulate molecular endpoints in vitro and appear to be within an order of magnitude of the levels needed to induce effects in animal models...
  3. ncbi Polyphenols: food sources and bioavailability
    Claudine Manach
    Unité des Maladies Métaboliques et Micronutriments, INRA, 63122 Saint Genes Champanelle, France
    Am J Clin Nutr 79:727-47. 2004
    ..A thorough knowledge of the bioavailability of the hundreds of dietary polyphenols will help us to identify those that are most likely to exert protective health effects...
  4. pmc Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Environ Health Perspect 116:39-44. 2008
    ..Bisphenol A (BPA) and 4-tertiary-octylphenol (tOP) are industrial chemicals used in the manufacture of polycarbonate plastics and epoxy resins (BPA) and nonionic surfactants (tOP). These products are in widespread use in the United States...
  5. ncbi Association between urinary bisphenol A concentration and obesity prevalence in children and adolescents
    Leonardo Trasande
    Department of Pediatrics, New York University School of Medicine, New York, NY 10016, USA
    JAMA 308:1113-21. 2012
    ..In adults, elevated urinary BPA concentrations are associated with obesity and incident coronary artery disease. BPA exposure is plausibly linked to childhood obesity, but evidence is lacking to date...
  6. ncbi The chemistry behind antioxidant capacity assays
    Dejian Huang
    Food Science and Technology Program, Department of Chemistry, National University of Singapore, Singapore 117543, Singapore
    J Agric Food Chem 53:1841-56. 2005
    ..ET-based assays include the total phenols assay by Folin-Ciocalteu reagent (FCR), Trolox equivalence antioxidant capacity (TEAC), ferric ion reducing ..
  7. pmc Urinary, circulating, and tissue biomonitoring studies indicate widespread exposure to bisphenol A
    Laura N Vandenberg
    Tufts Center for Regenerative and Developmental Biology, Tufts University, Medford, Massachusetts, USA
    Environ Health Perspect 118:1055-70. 2010
    ..Thus, there are concerns that the amount of BPA to which humans are exposed may cause adverse health effects. Importantly, results from a large number of biomonitoring studies are at odds with the results from two toxicokinetic studies...
  8. pmc Exposure to phthalates and phenols during pregnancy and offspring size at birth
    Claire Philippat
    Institut National de la Sante et de la Recherche Medicale, Institut Albert Bonniot U823, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Grenoble, France
    Environ Health Perspect 120:464-70. 2012
    Data concerning the effects of prenatal exposures to phthalates and phenols on fetal growth are limited in humans. Previous findings suggest possible effects of some phenols on male birth weight.
  9. ncbi Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults
    Iain A Lang
    Epidemiology and Public Health Group, Peninsula Medical School, Barrack Rd, Exeter EX2 5DW, UK
    JAMA 300:1303-10. 2008
    ..Bisphenol A (BPA) is widely used in epoxy resins lining food and beverage containers. Evidence of effects in animals has generated concern over low-level chronic exposures in humans...
  10. pmc Perinatal exposure to environmentally relevant levels of bisphenol A decreases fertility and fecundity in CD-1 mice
    Nicolas J Cabaton
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Environ Health Perspect 119:547-52. 2011
    ..Perinatal exposure to low-doses of bisphenol A (BPA) results in alterations in the ovary, uterus, and mammary glands and in a sexually dimorphic region of the brain known to be important for estrous cyclicity...
  11. ncbi Polyphenols and disease risk in epidemiologic studies
    Ilja C W Arts
    RIKILT Institute of Food Safety, Wageningen University and Research Centre, Wageningen, The Netherlands
    Am J Clin Nutr 81:317S-325S. 2005
    ..Careful design of prospective studies is important to offset some of the major drawbacks of epidemiologic studies, including residual confounding (by smoking and other dietary factors) and exposure assessment...
  12. pmc Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development
    Dana C Dolinoy
    Department of Radiation Oncology and University Program in Genetics and Genomics, Duke University, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 104:13056-61. 2007
    ..Thus, we present compelling evidence that early developmental exposure to BPA can change offspring phenotype by stably altering the epigenome, an effect that can be counteracted by maternal dietary supplements...
  13. ncbi Dietary polyphenols and the prevention of diseases
    Augustin Scalbert
    Laboratoire des Maladies Métaboliques et Micronutriments, INRA, Centre de Recherche de Clermont Ferrand Theix, St Genes Champanelle, France
    Crit Rev Food Sci Nutr 45:287-306. 2005
    ..More human studies are needed to provide clear evidence of their health protective effects and to better evaluate the risks possibly resulting from too high a polyphenol consumption...
  14. ncbi In vitro molecular mechanisms of bisphenol A action
    Yelena B Wetherill
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Reprod Toxicol 24:178-98. 2007
    ....
  15. ncbi Metabolism and kinetics of bisphenol a in humans at low doses following oral administration
    Wolfgang Völkel
    Institut fur Toxikologie, Universitat Wurzburg, Versbacher Strasse 9, 97078 Wurzburg, Germany
    Chem Res Toxicol 15:1281-7. 2002
    ..The efficient glucuronidation of bisphenol A and the rapid excretion of the formed glucuronide result in a low body burden of the estrogenic bisphenol A in humans following oral absorption of low doses...
  16. pmc In vivo effects of bisphenol A in laboratory rodent studies
    Catherine A Richter
    U S Geological Survey, Columbia Environmental Research Center, Columbia, MO 65201, United States
    Reprod Toxicol 24:199-224. 2007
    ..We consider it likely, but requiring further confirmation, that adult exposure to BPA affects the brain, the female reproductive system, and the immune system, and that developmental effects occur in the female reproductive system...
  17. ncbi Antioxidant activity and phenolic compounds in selected herbs
    W Zheng
    Fruit Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, U. S. Department of Agriculture, Beltsville, Maryland 20705, USA
    J Agric Food Chem 49:5165-70. 2001
    ..longiflora, whereas quercetin-3-O-rhamnosyl-(1 --> 2)-rhamnosyl-(1 --> 6)-glucoside and kaempferol-3-O-rhamnosyl-(1 --> 2)-rhamnosyl-(1 --> 6)-glucoside were predominant phenolic compounds in Ginkgo biloba leaves...
  18. ncbi Bisphenol A: an endocrine disruptor with widespread exposure and multiple effects
    Beverly S Rubin
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA 02111, United States
    J Steroid Biochem Mol Biol 127:27-34. 2011
    ..Although many questions remain to be answered, it is becoming increasingly apparent that exposure to BPA is ubiquitous and that the effects of this endocrine disruptor are complex and wide-ranging...
  19. pmc Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruption
    Laura N Vandenberg
    Tufts University School of Medicine, Department of Anatomy and Cellular Biology, 136 Harrison Avenue, Boston, Massachusetts 02111, USA
    Endocr Rev 30:75-95. 2009
    ....
  20. pmc Variability of urinary phthalate metabolite and bisphenol A concentrations before and during pregnancy
    Joe M Braun
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 120:739-45. 2012
    ..Gestational phthalate and bisphenol A (BPA) exposure may increase the risk of adverse maternal/child health outcomes, but there are few data on the variability of urinary biomarkers before and during pregnancy...
  21. pmc Urinary bisphenol A and obesity: NHANES 2003-2006
    Jenny L Carwile
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    Environ Res 111:825-30. 2011
    ..We hypothesized that urinary BPA concentrations would be positively associated with general and central obesity...
  22. ncbi Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer
    Yizhong Cai
    Department of Botany, The University of Hong Kong, Pokfulam Road, Hong Kong, PR China
    Life Sci 74:2157-84. 2004
    ..Traditional Chinese medicinal plants associated with anticancer might be potential sources of potent natural antioxidants and beneficial chemopreventive agents...
  23. pmc Impact of early-life bisphenol A exposure on behavior and executive function in children
    Joe M Braun
    Department of Environmental Health, Harvard School of Public Health, Harvard University, Boston, MA 02130, USA
    Pediatrics 128:873-82. 2011
    ..To estimate the impact of gestational and childhood bisphenol A (BPA) exposures on behavior and executive function at 3 years of age and to determine whether child gender modified those associations...
  24. ncbi Perinatal and postnatal exposure to bisphenol a increases adipose tissue mass and serum cholesterol level in mice
    Joji Miyawaki
    Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Ehime, Japan
    J Atheroscler Thromb 14:245-52. 2007
    ..To investigate whether the perinatal and postnatal exposure of mice to bisphenol A (BPA) caused the development of obesity and/or hyperlipidemia...
  25. ncbi Antioxidant properties, total phenols and pollen analysis of propolis samples from Portugal
    Leandro Moreira
    CIMO, Escola Superior Agraria, Instituto Politecnico de Braganca, Campus Santa Apolonia, Apartado 1172, 5301 855 Braganca, Portugal
    Food Chem Toxicol 46:3482-5. 2008
    Pollen analysis, total phenols content and antioxidant activity were studied for the first time in Portuguese propolis samples from Bornes and Fundão regions...
  26. pmc Short-term treatment with bisphenol-A leads to metabolic abnormalities in adult male mice
    Thiago M Batista
    Departamento de Anatomia, Biologia Celular, Fisiologia e Biofísica, Instituto de Biologia, Universidade Estadual de Campinas, UNICAMP, Campinas, Sao Paulo, Brazil
    PLoS ONE 7:e33814. 2012
    ..Thus, our findings support the notion that BPA can be considered a risk factor for the development of type 2 diabetes...
  27. pmc Temporal variability and predictors of urinary bisphenol A concentrations in men and women
    Shruthi Mahalingaiah
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, 665 Huntington Avenue, Boston, MA 02115, USA
    Environ Health Perspect 116:173-8. 2008
    ..Bisphenol A (BPA) is used to manufacture polymeric materials, such as polycarbonate plastics, and is found in a variety of consumer products. Recent data show widespread BPA exposure among the U.S. population...
  28. pmc Similarity of bisphenol A pharmacokinetics in rhesus monkeys and mice: relevance for human exposure
    Julia A Taylor
    Division of Biological Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Environ Health Perspect 119:422-30. 2011
    ..We measured unconjugated and conjugated BPA levels in serum from adult female rhesus monkeys and adult female mice after oral administration of BPA and compared findings in mice and monkeys with prior published data in women...
  29. ncbi Perinatal exposure to bisphenol A at reference dose predisposes offspring to metabolic syndrome in adult rats on a high-fat diet
    Jie Wei
    Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Endocrinology 152:3049-61. 2011
    ..High-fat diet intake is a trigger that initiates adverse metabolic effects of BPA...
  30. pmc Variability of urinary concentrations of bisphenol A in spot samples, first morning voids, and 24-hour collections
    Xiaoyun Ye
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 119:983-8. 2011
    ..Therefore, there is considerable within-person and between-person variability of BPA concentrations in spot urine samples. However, no information exists on the within-day variability of urinary BPA concentrations...
  31. pmc Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure
    Frederick S vom Saal
    Reprod Toxicol 24:131-8. 2007
  32. pmc The estrogenic effect of bisphenol A disrupts pancreatic beta-cell function in vivo and induces insulin resistance
    Paloma Alonso-Magdalena
    Instituto de Bioingenieria, Universidad Miguel Hernandez de Elche, Alicante, Spain
    Environ Health Perspect 114:106-12. 2006
    ..Therefore, either abnormal levels of endogenous estrogens or environmental estrogen exposure enhances the risk of developing type 2 diabetes mellitus, hypertension, and dyslipidemia...
  33. ncbi Temporal variability in urinary concentrations of phthalate metabolites, phytoestrogens and phenols among minority children in the United States
    S L Teitelbaum
    Mount Sinai School of Medicine, Department of Community and Preventive Medicine, 1 Gustave Levy Place, P O Box 1043, New York, NY 10029, USA
    Environ Res 106:257-69. 2008
    Exposure to endocrine disruptors (EDs), including some phthalates, phytoestrogens and phenols can be quantified using biomarkers of exposure...
  34. pmc Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06
    David Melzer
    Epidemiology and Public Health Group, Peninsula Medical School, University of Exeter, Exeter, United Kingdom
    PLoS ONE 5:e8673. 2010
    ..We aimed to estimate associations between urinary BPA concentrations and health measures in NHANES 2005/06 and in data pooled across collection years...
  35. pmc Comparison of serum bisphenol A concentrations in mice exposed to bisphenol A through the diet versus oral bolus exposure
    Paizlee T Sieli
    Department of Biomedical Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Environ Health Perspect 119:1260-5. 2011
    ..Bisphenol A (BPA) is a widely produced endocrine-disrupting chemical. Diet is a primary route of exposure, but internal exposure (serum concentrations) in animals and humans has been measured only after single oral bolus administration...
  36. pmc Bisphenol A: Perinatal exposure and body weight
    Beverly S Rubin
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA 02111, United States
    Mol Cell Endocrinol 304:55-62. 2009
    ..The mechanisms through which perinatal BPA exposure acts to exert persistent effects on body weight and adiposity remain to be determined. Possible targets of BPA action are discussed...
  37. pmc Protective effects of a Rhodiola crenulata extract and salidroside on hippocampal neurogenesis against streptozotocin-induced neural injury in the rat
    Ze qiang Qu
    Division of Neuroscience, Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, China
    PLoS ONE 7:e29641. 2012
    ..Our findings indicated that the RCE improved the impaired hippocampal neurogenesis in the rat model of AD through protecting NSCs by its main ingredient salidroside which scavenged intracellular ROS...
  38. pmc Biomonitoring of bisphenol A concentrations in maternal and umbilical cord blood in regard to birth outcomes and adipokine expression: a birth cohort study in Taiwan
    Wei Chun Chou
    Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan
    Environ Health 10:94. 2011
    ....
  39. pmc Relationship between urinary phthalate and bisphenol A concentrations and serum thyroid measures in U.S. adults and adolescents from the National Health and Nutrition Examination Survey (NHANES) 2007-2008
    John D Meeker
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
    Environ Health Perspect 119:1396-402. 2011
    ..Limited animal, in vitro, and human studies have reported that exposure to phthalates or bisphenol A (BPA) may affect thyroid signaling...
  40. pmc Relationship between urinary bisphenol A levels and diabetes mellitus
    Anoop Shankar
    Department of Community Medicine, West Virginia University School of Medicine, P O Box 9190, Morgantown, West Virginia 26506 9190, USA
    J Clin Endocrinol Metab 96:3822-6. 2011
    ..However, few human studies have examined the association between markers of BPA exposure and diabetes mellitus...
  41. pmc The estrogenic endocrine disrupting chemical bisphenol A (BPA) and obesity
    Frederick S vom Saal
    Division of Biological Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
    Mol Cell Endocrinol 354:74-84. 2012
    ....
  42. ncbi Urine bisphenol-A (BPA) level in relation to semen quality
    De Kun Li
    Division of Research, Kaiser Foundation Research Institute, Kaiser Permanente, Oakland, California, USA
    Fertil Steril 95:625-30.e1-4. 2011
    ..To determine whether urine bisphenol-A (BPA) levels are associated with lower semen quality...
  43. pmc Bisphenol-A exposure in utero leads to epigenetic alterations in the developmental programming of uterine estrogen response
    Jason G Bromer
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    FASEB J 24:2273-80. 2010
    ..Permanent epigenetic alteration of ERE sensitivity to estrogen may be a general mechanism through which endocrine disruptors exert their action...
  44. pmc Bisphenol A exposure during pregnancy disrupts glucose homeostasis in mothers and adult male offspring
    Paloma Alonso-Magdalena
    Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Universidad Miguel Hernandez de Elche, Elche, Spain
    Environ Health Perspect 118:1243-50. 2010
    ..In humans, epidemiological evidence has associated BPA exposure in adults with higher risk of type 2 diabetes and heart disease...
  45. ncbi Relationship of urinary bisphenol A concentration to risk for prevalent type 2 diabetes in Chinese adults: a cross-sectional analysis
    Guang Ning
    Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Ann Intern Med 155:368-74. 2011
    ..Greater bisphenol A exposure has been shown to be associated with a higher risk for self-reported adverse health outcomes, including diabetes...
  46. ncbi Beneficial effects of green tea--a review
    Carmen Cabrera
    Departamento de Nutricion y Bromatologia, Facultad de Farmacia, Campus Universitario de Granada, Granada, Spain
    J Am Coll Nutr 25:79-99. 2006
    ....
  47. pmc Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms
    Joi A Nichols
    Department of Dermatology, University of Alabama at Birmingham, 1670 University Boulevard, Volker Hall 557, PO Box 202, Birmingham, AL 35294, USA
    Arch Dermatol Res 302:71-83. 2010
    ..It is suggested that polyphenols may favorably supplement sunscreens protection, and may be useful for skin diseases associated with solar UV radiation-induced inflammation, oxidative stress and DNA damage...
  48. pmc Bisphenol A impairs the double-strand break repair machinery in the germline and causes chromosome abnormalities
    Patrick Allard
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:20405-10. 2010
    ..C. elegans therefore constitutes a model of remarkable relevance to mammals with which to assess how our chemical landscape affects germ cells and meiosis...
  49. pmc Perinatal exposure to bisphenol a alters early adipogenesis in the rat
    Emmanuel Somm
    Faculty of Medicine, University of Geneva, Geneva, Switzerland
    Environ Health Perspect 117:1549-55. 2009
    ..The causes of the current obesity pandemic have not been fully elucidated. Implication of environmental endocrine disruptors such as bisphenol A (BPA) on adipose tissue development has been poorly investigated...
  50. pmc Estrogen and xenoestrogens in breast cancer
    S V Fernandez
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Toxicol Pathol 38:110-22. 2010
    ..These studies provide firsthand evidence that the natural estrogen 17beta-estradiol and xenoestrogenic substances like bisphenol A are able to induce neoplastic transformation in human breast epithelial cells...
  51. ncbi Induction of reactive oxygen species by bisphenol A and abrogation of bisphenol A-induced cell injury by DJ-1
    Hiromasa Ooe
    Graduate School of Pharmaceutical Sciences, Graduate School of Agriculture, Hokkaido University, Sapporo 060 0812, Japan
    Toxicol Sci 88:114-26. 2005
    ..DJ-1 was found to maintain the complex I activity against BPA-induced oxidative stress after the localization in mitochondria. The results showed that DJ-1 plays a role in the prevention of mitochondrial injury-induced cell death...
  52. ncbi Three-generation reproductive toxicity study of dietary bisphenol A in CD Sprague-Dawley rats
    R W Tyl
    RTI, Research Triangle Park, North Carolina 27709 2194, USA
    Toxicol Sci 68:121-46. 2002
    ..001-5 mg/kg/day) on any parameters and no evidence of nonmonotonic dose-response curves across generations for either sex. BPA should not be considered a selective reproductive toxicant, based on the results of this study...
  53. ncbi Twenty-four hour human urine and serum profiles of bisphenol a during high-dietary exposure
    Justin G Teeguarden
    Fundamental and Computational Sciences, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
    Toxicol Sci 123:48-57. 2011
    ..During these high dietary exposures, (TOT)BPA concentrations in serum were undetectable in 83% of the 320 samples collected and BPA concentrations were determined to be less than or equal to LOD in all samples...
  54. ncbi Polyphenols: antioxidants and beyond
    Augustin Scalbert
    Laboratoire des Maladies Métaboliques et Micronutriments, Institut National de la Recherche Agronomique, Saint Genes Champanelle, France
    Am J Clin Nutr 81:215S-217S. 2005
    ....
  55. pmc Investigation of relationships between urinary biomarkers of phytoestrogens, phthalates, and phenols and pubertal stages in girls
    Mary S Wolff
    Mount Sinai School of Medicine, New York, NY 10029, USA
    Environ Health Perspect 118:1039-46. 2010
    ..Hormonally active environmental agents may alter the course of pubertal development in girls, which is controlled by steroids and gonadotropins...
  56. pmc Rapid insulinotropic action of low doses of bisphenol-A on mouse and human islets of Langerhans: role of estrogen receptor β
    Sergi Soriano
    Instituto Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Universidad Miguel Hernandez de Elche, Elche, Alicante, Spain
    PLoS ONE 7:e31109. 2012
    ..This supports that BPA should be considered as a risk factor for metabolic disorders in humans...
  57. ncbi Urinary bisphenol A (BPA) concentration associates with obesity and insulin resistance
    Tiange Wang
    Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    J Clin Endocrinol Metab 97:E223-7. 2012
    ..Bisphenol A (BPA) is one of the world's highest-volume chemicals in use today. Previous studies have suggested BPA disturbs body weight regulation and promotes obesity and insulin resistance. But epidemiological data in humans were limited...
  58. pmc Bisphenol A data in NHANES suggest longer than expected half-life, substantial nonfood exposure, or both
    Richard W Stahlhut
    Environmental Health Sciences Center, University of Rochester Medical Center, Rochester, New York 14642, USA rochester edu
    Environ Health Perspect 117:784-9. 2009
    ..If this is correct, BPA levels in fasting individuals should decrease with increased fasting time...
  59. ncbi Effect of environmental contaminants on Beta cell function
    Emilija Makaji
    Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Int J Toxicol 30:410-8. 2011
    ..These data suggest that long-term BPA exposure may be detrimental to beta cell function and ultimately be an important contributor to the etiology of T2D...
  60. pmc Food packaging and bisphenol A and bis(2-ethyhexyl) phthalate exposure: findings from a dietary intervention
    Ruthann A Rudel
    Silent Spring Institute, Newton, Massachusetts 02458, USA
    Environ Health Perspect 119:914-20. 2011
    ..They have been associated with endocrine disruption in animals and in some human studies. Human exposure sources have been estimated, but the relative contribution of dietary exposure to total intake has not been studied empirically...
  61. ncbi Positive relationship between androgen and the endocrine disruptor, bisphenol A, in normal women and women with ovarian dysfunction
    Toru Takeuchi
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Japan
    Endocr J 51:165-9. 2004
    ..514, p<0.001) concentrations in all subjects. These findings show that there is a strong relationship between serum BPA and androgen concentrations, speculatively due to the effect of androgen on the metabolism of BPA...
  62. pmc Variability and predictors of urinary bisphenol A concentrations during pregnancy
    Joe M Braun
    Department of Environmental Health, Harvard University, Boston, Massachusetts, USA
    Environ Health Perspect 119:131-7. 2011
    ..Prenatal bisphenol A (BPA) exposure may be associated with developmental toxicity, but few studies have examined the variability and predictors of urinary BPA concentrations during pregnancy...
  63. pmc Bisphenol A alters the development of the rhesus monkey mammary gland
    Andrew P Tharp
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 109:8190-5. 2012
    ..No significant differences were observed in ER expression. Altogether, gestational exposure to the estrogen-mimic BPA altered the developing mammary glands of female nonhuman primates in a comparable manner to that observed in rodents...
  64. ncbi Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: a potential novel mechanism of endocrine disruption
    Peter Thomas
    Marine Science Institute, University of Texas at Austin, 750 Channel View Drive, Port Aransas, TX 78373, USA
    J Steroid Biochem Mol Biol 102:175-9. 2006
    ..The results indicate that nontraditional estrogen actions mediated through GPR30 are potentially susceptible to disruption by a variety of environmental estrogens...
  65. pmc Components of plastic: experimental studies in animals and relevance for human health
    Chris E Talsness
    Department of Toxicology, Institute of Clinical Pharmacology and Toxicology, Charité University Medical School Berlin, Berlin, Germany
    Philos Trans R Soc Lond B Biol Sci 364:2079-96. 2009
    ....
  66. pmc Pancreatic insulin content regulation by the estrogen receptor ER alpha
    Paloma Alonso-Magdalena
    Instituto de Bioingenieria, Universidad Miguel Hernandez de Elche, Alicante, Spain
    PLoS ONE 3:e2069. 2008
    ..The up-regulation of pancreatic insulin content by ER alpha activation involves ERK1/2. These data may be important to explain the actions of E2 and environmental estrogens in endocrine pancreatic function and blood glucose homeostasis...
  67. ncbi Absolute pK(a) determinations for substituted phenols
    Matthew D Liptak
    Department of Chemistry, Hamilton College, 198 College Hill Road, Clinton, New York 13323, USA
    J Am Chem Soc 124:6421-7. 2002
    The CBS-QB3 method was used to calculate the gas-phase free energy difference between 20 phenols and their respective anions, and the CPCM continuum solvation method was applied to calculate the free energy differences of solvation for ..
  68. ncbi The estrogen receptor relative binding affinities of 188 natural and xenochemicals: structural diversity of ligands
    R M Blair
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Toxicol Sci 54:138-53. 2000
    ..The current study provides the most structurally diverse ER RBA data set with the widest range of RBA values published to date...
  69. pmc Semen quality and sperm DNA damage in relation to urinary bisphenol A among men from an infertility clinic
    John D Meeker
    Department of Environmental Health Sciences, University of Michigan School of Public Health, 109 S Observatory St, Ann Arbor, MI 48109, USA
    Reprod Toxicol 30:532-9. 2010
    ..03%, 19%) increase in sperm DNA damage measured as the percentage of DNA in comet tail. In conclusion, urinary BPA may be associated with declined semen quality and increased sperm DNA damage, but confirmatory studies are needed...
  70. pmc Mechanism of antifungal activity of terpenoid phenols resembles calcium stress and inhibition of the TOR pathway
    Anjana Rao
    Department of Physiology, Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA
    Antimicrob Agents Chemother 54:5062-9. 2010
    Terpenoid phenols, including carvacrol, are components of oregano and other plant essential oils that exhibit potent antifungal activity against a wide range of pathogens, including Candida albicans, Staphylococcus aureus, and ..
  71. ncbi Viable skin efficiently absorbs and metabolizes bisphenol A
    Daniel Zalko
    INRA, UMR1089 Xenobiotiques, 180 chemin de Tournefeuille, BP 93173, 31027 Toulouse Cedex 3, France
    Chemosphere 82:424-30. 2011
    ..The trans-dermal route is expected to contribute substantially to BPA exposure in human, when direct contact with BPA (free monomer) occurs...
  72. ncbi Transfer of bisphenol A from thermal printer paper to the skin
    Sandra Biedermann
    Official Food Control Authority of the Canton of Zurich, P O Box 1471, CH 8032, Zurich, Switzerland
    Anal Bioanal Chem 398:571-6. 2010
    ..However, if more than just the finger pads contact the BPA-containing paper or a hand cream enhances permeability of the skin, this margin might be smaller...
  73. ncbi Phenolic acid composition and antioxidant properties of Malaysian honeys
    M I Khalil
    Dept of Pharmacology, School of Medical Sciences, Univ Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
    J Food Sci 76:C921-8. 2011
    ..We conclude that among Malaysian honey samples, Tualang honey is the richest in phenolic acids, and flavonoid compounds, which have strong free radical-scavenging activities...
  74. pmc Daily bisphenol A excretion and associations with sex hormone concentrations: results from the InCHIANTI adult population study
    Tamara Galloway
    School of Biosciences, University of Exeter, Exeter, United Kingdom
    Environ Health Perspect 118:1603-8. 2010
    ..Bisphenol A (BPA) is a high production volume chemical widely used in packaging for food and beverages. Numerous studies have demonstrated that BPA can alter endocrine function in animals, yet human studies remain limited...
  75. ncbi Wine phenolics
    Andrew L Waterhouse
    Department of Viticulture and Enology, University of California, Davis, California 95616 8749, USA
    Ann N Y Acad Sci 957:21-36. 2002
    ..The total amount of phenols found in a glass of red wine is on the order of 200 mg versus about 40 mg in a glass of white wine.
  76. pmc Bisphenol A impairs follicle growth, inhibits steroidogenesis, and downregulates rate-limiting enzymes in the estradiol biosynthesis pathway
    Jackye Peretz
    Department of Comparative Biosciences, University of Illinois, Urbana, Illinois 61802, USA
    Toxicol Sci 119:209-17. 2011
    ..Collectively, these data show that BPA targets the estradiol biosynthesis pathway in the ovary...
  77. pmc Human body burdens of chemicals used in plastic manufacture
    Holger M Koch
    BGFA Research Institute of Occupational Medicine, German Social Accident Insurance, Ruhr University Bochum, Bochum, Germany
    Philos Trans R Soc Lond B Biol Sci 364:2063-78. 2009
    ..We discuss several factors relevant for interpreting and understanding biomonitoring data, including selection of both biomarkers of exposure and human matrices, and toxicokinetic information...
  78. pmc Case report: high prenatal bisphenol a exposure and infant neonatal neurobehavior
    Sheela Sathyanarayana
    Department of Pediatrics, University of Washington, Seattle, Washington 98145 5005, USA
    Environ Health Perspect 119:1170-5. 2011
    ..Most of the U.S. population is exposed to the high-production-volume chemical bisphenol A (BPA), but targetable sources of exposure remain to be determined. Animal studies and one human study suggest that BPA is a neurotoxicant...
  79. pmc Urinary bisphenol A and type-2 diabetes in U.S. adults: data from NHANES 2003-2008
    Monica K Silver
    Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 6:e26868. 2011
    ..We used a different diagnosis method of T2DM (hemoglobin A1c (HbA1c)) with a larger subset of NHANES...
  80. pmc Effects of bisphenol A on adipokine release from human adipose tissue: Implications for the metabolic syndrome
    Nira Ben-Jonathan
    Department of Cancer and Cell Biology, University of Cincinnati, OH 45267, USA
    Mol Cell Endocrinol 304:49-54. 2009
    ..The implications of these observations to the obesity-related metabolic syndrome and its sequelae are discussed...
  81. pmc Prenatal bisphenol A exposure and early childhood behavior
    Joe M Braun
    Department of Epidemiology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA
    Environ Health Perspect 117:1945-52. 2009
    ..Prenatal exposure to bisphenol A (BPA) increases offspring aggression and diminishes differences in sexually dimorphic behaviors in rodents...
  82. ncbi Antioxidant activity of apple peels
    Kelly Wolfe
    Institute of Comparative and Environmental Toxicology and Department of Food Science, Stocking Hall, Cornell University, Ithaca, New York 14853 7201, USA
    J Agric Food Chem 51:609-14. 2003
    ..The high content of phenolic compounds, antioxidant activity, and antiproliferative activity of apple peels indicate that they may impart health benefits when consumed and should be regarded as a valuable source of antioxidants...
  83. pmc Oral exposure to bisphenol a increases dimethylbenzanthracene-induced mammary cancer in rats
    Sarah Jenkins
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Environ Health Perspect 117:910-5. 2009
    ..Bisphenol A (BPA) is widely used in the manufacture of polycarbonate plastics, including infant formula bottles...
  84. ncbi Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects? Antioxidant or not?
    Barry Halliwell
    Department of Biochemistry, Faculty of Medicine, Singapore
    Am J Clin Nutr 81:268S-276S. 2005
    ..However, it remains unclear whether this protective effect is attributable to the phenols or to other agents in the diet...
  85. pmc Urinary concentrations of bisphenol A and 4-nonylphenol in a human reference population
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 113:391-5. 2005
    ..S. population) and relatively small size, this study provides the first reference range of human internal dose levels of BPA and NP in a demographically diverse human population...
  86. pmc Bisphenol A at environmentally relevant doses inhibits adiponectin release from human adipose tissue explants and adipocytes
    Eric R Hugo
    Department of Cell and Cancer Biology, University of Cincinnati, 3125 Eden Avenue, Cincinnati, OH 45267, USA
    Environ Health Perspect 116:1642-7. 2008
    ..Thus, any factor that suppresses adiponectin release could lead to insulin resistance and increased susceptibility to obesity-associated diseases...
  87. ncbi Challenges for research on polyphenols from foods in Alzheimer's disease: bioavailability, metabolism, and cellular and molecular mechanisms
    Manjeet Singh
    INRS Institut Armand Frappier, 531 Boulevard des Prairies, Laval, Quebec H7V 1B7, Canada
    J Agric Food Chem 56:4855-73. 2008
    ..The focus of this review is aimed at presenting the role of some polyphenols from fruits, vegetables, and beverages in neuroprotection and particularly in Alzheimer's disease and the research challenges in this area...
  88. ncbi Bisphenol-A, an environmental contaminant that acts as a thyroid hormone receptor antagonist in vitro, increases serum thyroxine, and alters RC3/neurogranin expression in the developing rat brain
    R Thomas Zoeller
    Biology Department, Morrill Science Center, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Endocrinology 146:607-12. 2005
    ....
  89. ncbi Salidroside attenuates apoptosis in ischemic cardiomyocytes: a mechanism through a mitochondria-dependent pathway
    Han Zhong
    Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China
    J Pharmacol Sci 114:399-408. 2010
    ..These findings suggest that salidroside reduced ischemia-mediated myocardial damage. Salidroside therefore has potential to be a promising drug for preventing and treating myocardial ischemic diseases...
  90. ncbi Bisphenol A induces reactive oxygen species generation in the liver of male rats
    V Bindhumol
    School of Life Sciences, Pondicherry University, Pondicherry 605 014, India
    Toxicology 188:117-24. 2003
    ..The results indicated that bisphenol A induces oxidative stress in the liver of rats by decreasing the antioxidant enzymes. Co-administration of vitamin C reversed the effects of bisphenol A-induced oxidative stress in the liver of rats...
  91. ncbi Quantification of urinary conjugates of bisphenol A, 2,5-dichlorophenol, and 2-hydroxy-4-methoxybenzophenone in humans by online solid phase extraction-high performance liquid chromatography-tandem mass spectrometry
    Xiaoyun Ye
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, Mailstop F17, Atlanta, GA 30341, USA
    Anal Bioanal Chem 383:638-44. 2005
    Urinary concentrations of phenols or their metabolites have been used as biomarkers to assess the prevalence of exposure to these compounds in the general population...
  92. ncbi Thyroid hormone action is disrupted by bisphenol A as an antagonist
    Kenji Moriyama
    Department of Medicine and Clinical Science, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    J Clin Endocrinol Metab 87:5185-90. 2002
    ..This is the first report that BPA can antagonize T(3) action at the transcriptional level. BPA may disrupt the function of various types of nuclear hormone receptors and their cofactors to disturb our internal hormonal environment...
  93. ncbi Urinary concentrations of phthalates and phenols in a population of Spanish pregnant women and children
    Lidia Casas
    Centre for Research in Environmental Epidemiology, Barcelona, Catalonia, Spain
    Environ Int 37:858-66. 2011
    ..Phthalate and phenol exposure is prevalent among the general population and of potential concern for pregnant women and children because of their suspected susceptibility to endocrine effects...
  94. ncbi Widespread occurrence of bisphenol A in paper and paper products: implications for human exposure
    ChunYang Liao
    Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Empire State Plaza, P O Box 509, Albany, New York 12201 0509, United States
    Environ Sci Technol 45:9372-9. 2011
    ..Among paper products, thermal receipt papers contributed to the majority (>98%) of the exposures...
  95. pmc Estrogenic activity of bisphenol A and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE) demonstrated in mouse uterine gene profiles
    Sylvia C Hewitt
    Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 119:63-70. 2011
    ..Comparison of E2 uterine transcript profiles and those of other estrogenic chemicals of interest in vivo indicates mechanisms and activities of test compounds...
  96. ncbi Levels of bisphenol A in canned soft drink products in Canadian markets
    Xu Liang Cao
    Food Research Division, Bureau of Chemical Safety, Food Directorate, Health Canada, 251 Frederick Banting Driveway, AL 2203D, Ottawa, Ontario, Canada
    J Agric Food Chem 57:1307-11. 2009
    ..5 microg/L) for an adult with a 60 kg body weight, well below the provisional tolerable daily intake of 25 microg/kg of body weight/day established by Health Canada...
  97. ncbi GerES IV: phthalate metabolites and bisphenol A in urine of German children
    Kerstin Becker
    Federal Environment Agency UBA, Dessau Rosslau Berlin, Germany
    Int J Hyg Environ Health 212:685-92. 2009
    ..7microg/l. A rough calculation of the daily intakes on the basis of the measured concentrations in urine resulted in daily intakes two orders of magnitude lower than the current EFSA reference dose of 50microg/kgbw/d...
  98. pmc Gestational exposure to bisphenol A and cross-fostering affect behaviors in juvenile mice
    Kimberly H Cox
    Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Horm Behav 58:754-61. 2010
    ..Our results show that prenatal BPA exposure affects social behavior and anxiety in the EPM. Moreover, some facet(s) of the infant-maternal interaction may modify these effects...
  99. ncbi Pharmacokinetics of bisphenol A in neonatal and adult rhesus monkeys
    Daniel R Doerge
    Division of Biochemical Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079, USA
    Toxicol Appl Pharmacol 248:1-11. 2010
    ....
  100. ncbi Neuroprotective effects of salidroside in the PC12 cell model exposed to hypoglycemia and serum limitation
    Shu Yu
    Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, JS 226001, People s Republic of China
    Cell Mol Neurobiol 28:1067-78. 2008
    ..Our findings might raise a possibility of potential therapeutic applications of salidroside for preventing and treating cerebral ischemic and neurodegenerative diseases...
  101. pmc Preliminary phytochemical screening and in vitro antioxidant activities of the aqueous extract of Helichrysum longifolium DC
    Olayinka A Aiyegoro
    Applied and Environmental Microbiology Research Group AEMREG, Department of Biochemistry and Microbiology, University of Fort Hare, Private Bag X1314, Alice 5700, South Africa
    BMC Complement Altern Med 10:21. 2010
    ..The aims of this study were to evaluate in vitro antioxidant activities and to screen for phytochemical constituents of Helichrysum longifolium DC. [Family Asteraceae] aqueous crude extract...

Research Grants62

  1. Synthesis of Medicinally Important Heterocycles
    RICHARD LAROCK; Fiscal Year: 2007
    ..pyrroles, oxazoles, isoxazoles, pyrazoles, pyridines, quinolines, coumarins, indenes, indenones, naphthols, and phenols. Sequential iodocyclization, Sonogashira coupling and further electrophilic cyclization appears promising as an ..
  2. BIOINORGANIC COPPER COORDINATION CHEMISTRY
    Kenneth D Karlin; Fiscal Year: 2013
    ..These will include oxidation of phenols, substrates with weak C-H bonds and electron-proton reduction to copper-hydroperoxo complexes...
  3. Coupled Transfers of Electrons and Protons
    James M Mayer; Fiscal Year: 2013
    ..The systems to be examined include phenols, iron porphyrins, ruthenium complexes, and models for iron/sulfur cluster cofactors...
  4. Chemical Exposures and Infant Outcomes in the Neonatal Intensive Care Unit
    Annemarie Stroustrup; Fiscal Year: 2013
    ..methods;and 3) apply the lessons learned to a research project examining biomarkers of exposure to phthalates, phenols, cadmium, and manganese and infant medical and neurobehavioral development...
  5. Understanding protein radicals
    Cecilia Tommos; Fiscal Year: 2012
    ..The hydrogen-bonding interactions of the oxidized phenols in the 2- and 3-mercaptophenol-13C proteins will be determined by electron magnetic-resonance spectroscopy...
  6. Structure and Mechanisms of Styrene Monooxygenase
    George T Gassner; Fiscal Year: 2010
    ..hydroxylation reactions to yield strong alkylating agents and pulmonary irritants such as styrene oxide and vinyl phenols. The long-term objective of our research is to elucidate the structures and mechanisms of the enzymes engaged in ..
  7. LSU Superfund Research Center - Environmentally Persistent Free Radicals
    Barry Dellinger; Fiscal Year: 2013
    ..Our researchers have discovered chlorinated aromatic hydrocarbons and substituted phenols chemisorb to the surfaces of particulate matter containing redoxactive transition metals where they reduce the ..
  8. Phase II Environmentally greener, efficient, and safe synthetic platform for the
    PAUL MATTHEW HERRINTON; Fiscal Year: 2011
    ..b>Phenols are commercially important compounds that are extensively utilized, especially in the area of drug discovery, ..
  9. Chemo-enzymatic Approach to Late-stage Aromatic Fluorination of Drug Scaffolds
    RYAN MARK LAUCHLI; Fiscal Year: 2012
    ..2,3] This proposal describes a novel strategy to address the significant challenge of accessing phenols by selective enzymatic aromatic hydroxylation...
  10. Delivery of Polyphenols in Gum for Treatment of Gingivitis
    Craig Miller; Fiscal Year: 2009
    ..will, i) complete development of qualified stability-indicating analytical method for anthocyanins and phenols in the blackberry extract and the gum prototype, ii) develop methods to extract anthocyanins and phenols from the ..
  11. Taste psychophysics of bitter phytochemicals
    MIRIAM LINSCHOTEN; Fiscal Year: 2005
    Diets rich in vegetables and fruit lower the risk of cancer and other systemic diseases. Phytochemicals such as phenols, flavonoids, isoflavones, terpenes and glucosinolates have anti-oxidant and anti-carcinogenic properties and ..
  12. INACTIVATION AND STRUCTURE AND GABA AMINOTRANSFERASE
    Richard Silverman; Fiscal Year: 1999
    ..and the corresponding acetylenic and fluoromethyl inactivator analogs, substituted phenols as lipophilic isosteres of carboxylic acids, 4-amino-2-difluoromethyl- 2-butenoic acid, 4-amino-2-trifluromethyl-..
  13. H-BONDS AND PROTON TRANSFER IN MODEL PIGMENT CHROMOPHORE
    PAUL BLATZ; Fiscal Year: 1990
    ..Some of the experimental variables to be studied are: i) donor reagents such as phenol, substituted phenols, acetic acid and chloro substituted acetic acids, ii) selected solvents such as hydrocarbons and ..
  14. CHLORINATED HYDROCARBONS EFFECTS ON MAMMALIAN SYSTEMS
    David Kupfer; Fiscal Year: 2003
    ..The mechanism of hydroxylation of phenolic M-metabolites in particular and of phenols in general (forming catechols) by CYP3A4, the major human P450, will be investigated...
  15. PHENOLS/CATECHOLS IN OCCUPATIONAL/CONTACT VITILIGO SKIN
    Raymond Boissy; Fiscal Year: 2002
    ....
  16. Enantioselective Catalysis with Cyclopropenimines
    Tristan H Lambert; Fiscal Year: 2013
    ..low acidity nucleophiles, including diazoesters;allylic alkylations;and enantioselective conjugate additions of phenols, amines, and nitrogen heterocycles...
  17. GLUTATHIONE PATHWAY TO THE FORMATION OF PHENOLS
    KHINGKAN LERTRATANANGKOON; Fiscal Year: 1992
    ..The formation of phenols through this pathway is species dependent...
  18. NATURAL SUBSTRATES AND INHIBITORS OF MICROBIAL MDR PUMPS
    Kim Lewis; Fiscal Year: 2002
    ..a large collection of substances, representing the main types of antimicrobials (alkaloids, flavones, quinones, phenols) coming from a variety of unrelated plants...
  19. MECHANISMS BY WHICH CHLOROPHENOLS ACT AS CYTOTOXINS
    E Bittar; Fiscal Year: 1991
    ..represents a new approach, particularly since virtually nothing is known about the cytoxicity of chlorinated phenols e.g. pentachlorophenol, as it relates to membrane transport mechanisms...
  20. Proposal for the Enantioselective Total Synthesis of N-Methylwelwitindolinone C I
    John A Enquist; Fiscal Year: 2013
    ..of an enantioselective oxidative dearomatization reaction for the coupling of aryl halides with ortho-carboxy phenols. This new method will provide access to enantioenriched cyclohexadienone products bearing all-carbon 1-quaternary ..
  21. Arthropod-Based Libraries for High Throughput Screening
    Frank Schroeder; Fiscal Year: 2009
    ..we have characterized have simple structures (such as straight chain alkenes, carboxylic acids, aldehydes, phenols, benzoquinones), there are also many examples of biologically active alkaloids, isoprenoids (including steroids), ..
  22. MEMBRANE-BASED PRECONCENTRATORS FOR BIOMOLECULES
    James Cox; Fiscal Year: 1991
    ..The test compounds will include aromatic amines, fatty acids, selected amino acids, polypeptides, phenols and polychlorinated biphenyls. These are of interest to either biological or environmental chemistry...
  23. MECHANISM(S) OF TOXICITY OF THE CHLORINATED P-DIOXINS
    Robert Neal; Fiscal Year: 1980
    ..are a class of generally toxic compounds which are found as contaminants of preparations of polychlorinated phenols. The most toxic member of this class of compounds is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)...
  24. Reproductive Outcomes due to Past Exposure to Dioxins
    Irina Dardynskaia; Fiscal Year: 2005
    ..Dardynskaia?s research study is to assess whether a cohort of chemical workers exposed to chlorinated phenols, chiorphenoxy acids, and their chlorinated dioxin and dibenzofuran contaminants at the Khimprom chemical plant in ..
  25. TOXICITY OF CHLOROPHENOLS IN MITOCHONDRIAL MEMBRANES
    Pavel Smejtek; Fiscal Year: 1990
    Studies of oxidative phosphorylation in the inner membranes of mitochondria in the presence of chlorinated phenols will be complemented by studies on lipid bilayer membranes in order to determine the physico-chemical origin of the ..
  26. BINUCLEAR MIXED-METAL DERIVATIVES OF TYROSINASE
    KENNETH STROTHKAMP; Fiscal Year: 1991
    ..throughout the phylogenetic scale, catalyzes the first two steps in the biosynthesis of melanin: hydroxylation of phenols (a monooxygenase reaction) and the oxidation of catechols to quinones (an oxidase reaction)...
  27. HEPATIC FORMATION AND TOXICITY OF CATECHOLS
    RUTH BILLINGS; Fiscal Year: 1990
    ..in isolated rat liver cells occurs primarily via oxidation of dihydrodiols, rather than by hydroxylation of phenols. The proposed studies will extend these observations to include rabbits and mice, and will determine the ..
  28. Center of Excellence in Chemical Methodologies and Library Development
    JEFFREY AUBE; Fiscal Year: 2012
    ..These range from C-H functionalization reactions of phenols to Pd-promoted multicomponent reactions to the strategic deployment of a sulfonamide-forming "click" reaction...
  29. Stress proteins in autoimmune depigmentation
    ISABELLE LE POOLE; Fiscal Year: 2005
    ..Precipitating factors include mechanical injury, contact with bleaching phenols, and overexposure to UV light...
  30. BIOACTIVATION OF DIETARY PHENOLS BY HEMOPROTEINS
    John Thompson; Fiscal Year: 2007
    ..abstract_text> ..
  31. CU-Catalyzed C(aryl)-N and C(aryl)-O Bond-forming Reactions
    RYAN ALTMAN; Fiscal Year: 2007
    ..the Cu-catalyzed reactions of aryl iodides and bromides with nucleophiles to provide protected and unprotected phenols, silyl enol ethers, diaryl amines and triaryl amines...
  32. SYNTHETIC UTILITY OF CYCLOBUTENONES
    Harold Moore; Fiscal Year: 1999
    ..allenyl and aryl)cyclobutenones and related imino-, thio-, and alkylidenyl- analogs to quinones, hydroquinones, phenols, heteroaromatics and a variety of cyclic aliphatic compounds...
  33. IMMUNOTOXICOLOGY OF PHENOLS ON EPIDERMAL IMMUNE CELLS
    James Nordlund; Fiscal Year: 1990
    Phenolic compounds, natural or synthetic, are ubiquitous in man's environment. Phenols have complicated effects on biological systems...
  34. PROTECTION AGAINST BENZO{A} PYRENE TOXICITY BY OLTIPRAZ
    JOSEPH RITTER; Fiscal Year: 2004
    ..The level of hepatic glucuronidating activity towards benzo[a]pyrene phenols, quinols, and dihydrodiols, appears to represent a key risk factor underlying susceptibility to B[a]P's genotoxic ..
  35. Oxidative Stress, Antioxidants and Breast Cancer Risk
    Qi Dai; Fiscal Year: 2007
    ..5% cohort members. For this proposed study, urinary level of total phenols will be assayed with Folin-Ciocalteu Phenol Reagent, urinary levels of polyphenol flavonols and flavanols will be ..
  36. BIOMEDICAL RESEARCH PROGRAM
    JULIETTE BELL; Fiscal Year: 2000
    ..Aryloxypropanolanies from 3-azetidinols and phenols (Higgins) 3. Characterization of ceftazidime resistance in Klebsiella pneumoniae (Raynor) 4...
  37. TOWARD A PREDICTIVE TOXICOLOGY
    CYNTHIA SELASSIE; Fiscal Year: 2000
    ..to enhance our understanding of the beneficial and toxic attributes of free radicals with particular emphasis on phenols, anilines and benzylic type compounds entities with active hydrogens...
  38. De novo design of type 3 copper proteins
    Michael Rosenblatt; Fiscal Year: 2003
    ..We also aim to produce models that bind and convert phenols to catechols, capable of also performing oxidations...
  39. SYNTHESIS OF SELECTED CHEMICAL CARCINOGENS
    Shantu Amin; Fiscal Year: 2000
    ..The types of compounds, referred to as PAH metabolites, include dihydrodiols, phenols, quinones, enantiomeric diolepoxides, epoxides, dialdehydes resulting from the cleavage of vicinally-..
  40. PHARMACOLOGY OF CARCINOGEN ACTIVATION IN INTACT CELLS
    FREDERICK KAUFFMAN; Fiscal Year: 1991
    ..This latter goal will be approached by studying the release of benzo(a)pyrene conjugates and phenols from livers preloaded with benzo(a)pyrene and transplanted into normal rats...
  41. Evaluation of Neuroprotective Compounds for Glaucoma
    James Dykens; Fiscal Year: 2003
    ..be cytoprotective in other neuronal cell types These compounds are from a proprietary library of novel polycyclic phenols (PPCs) know to stabilize mitochondrial function in other neuronal cell types both in vitro and in vivo The ..
  42. ESTERIFICATION OF ESTROGENS AND LIPID PEROXIDATION
    RICHARD HOCHBERG; Fiscal Year: 2003
    ..We will design and synthesize non-estrogenic alkylhydroxy substituted phenols as substrates for LCAT and inhibitors of LDL oxidation...
  43. Structural studies of phenyl propanoid metabolism
    Chulhee Kang; Fiscal Year: 2005
    ..aims to define the mode of action of the first known protein able to control the binding and orientation of plant phenols (monolignol derived) in order that stereoselective coupling can occur...
  44. Growth Control of Prostate Cancer Cells by Plant Phenols
    Charles Young; Fiscal Year: 2005
    ..Plant phenols are regular constituents of plant foods in human diets...
  45. SURFACE ENHANCED RAMAN SPECTROSCOPY OF NEUROTRANSMITTERS
    Michael Morris; Fiscal Year: 1991
    ..The mechanism of 19a catecholamine adsorption at a silver electrode will be elucidated, using substituted phenols and catechols and dopamine and norepinephrine agonists of known structure...
  46. THE ROLE OF FREE RADICALS AND ANTIOXIDANTS IN AGING
    THEODORE MILL; Fiscal Year: 1980
    ..We then propose to extend these measurements in bilayers to combinations of antioxidants to look for synergistic effects between Vit. E and BHT and between BHT or E and unhindered phenols.
  47. Neuropharmacology of GHB discrimination
    Wouter Koek; Fiscal Year: 2010
    ..Increased knowledge about the activation and modulation of GABAB systems will help to develop effective approaches to treating sleep-, drug abuse-, and other CNS disorders. ..
  48. Estrogens for Alcoholism & Its Neurological Consequences
    James Simpkins; Fiscal Year: 2008
    ..the proposed studies will provide new knowledge on the mechanism of estrogen protection from the consequences of EW and determine if estrogens are potential pharmacotherapies for alcoholism and its consequences [unreadable] [unreadable]..
  49. ARYL AND ALCOHOL SULFOTRANSFERASES IN DRUG METABOLISM
    Michael W Duffel; Fiscal Year: 2010
    ..Moreover, specific aim #1 has additional particular relevance to understanding and more accurately predicting the metabolism of Tamoxifen, a widely used antitumor agent and chemopreventive agent for estrogen-dependent breast cancer. ..
  50. Discriminative Stimulus Effects of Alcohol in Mice
    Wouter Koek; Fiscal Year: 2007
    ..This future research will increase our understanding of risk factors for alcoholism and drug abuse and will help the development of effective approaches to prevention and treatment. [unreadable] [unreadable] [unreadable]..
  51. Search for the Molecular Targets of Phenols
    CYNTHIA SELASSIE; Fiscal Year: 2006
    ..Patterns of behavior of simple and complex phenols have not been systematically addressed for a very important class of compounds whose reactive functional group is ..
  52. Flourescent Ceramic Nanoprobes (RMI)
    TIMOTHY BOYLE; Fiscal Year: 2008
    ..All of the innovations uncovered during the preparation of these nanoprobes will be shared in order to benefit medical research applications beyond those proposed in this investigation. ..
  53. Synthesis of the myrmicarin family of natural products
    Scott Snyder; Fiscal Year: 2005
    ....
  54. Prenatal NSAID Use and Miscarriage
    De Kun Li; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  55. Acquisition of LMD6000 Laser Microdissection Unit
    LAURA VAN WINKLE; Fiscal Year: 2008
    ..The overall benefits to the UC Davis campus are many. This equipment fits well with the research needs of the UC Davis community, which has included a recent emphasis on genomics. [unreadable] [unreadable] [unreadable]..
  56. METABOLISM AND TOXICITY OF HALOGENATED HYDROCARBONS
    MARION ANDERS; Fiscal Year: 2004
    ..Hence, DCA may also find use in the management of HT-1. It is, therefore, important to explore the mechanism by which DCA and other dihaloacetates inactivate GSTZ1-1. ..
  57. SYNTHESIS OF NATURAL PRODUCTS WITH OXAZOLE MOIETIES
    Peter Wipf; Fiscal Year: 2005
    ..The proposed program represents a multi-dimensional effort to increase the basic knowledge of the function of marine natural products, establish new methods in heterocyclic chemistry, and identify novel pharmacophores. ..
  58. MECHANISTIC STUDIES ON TEA AND CARCINOGENESIS
    Chung Yang; Fiscal Year: 2005
    ..The applicant and colleagues will address key issues concerning the bioavailability and bioactivities of O-methyl, glucuronide, and sulfate derivatives and two ring-fission metabolites of tea catechins. ..