organophosphorus compounds

Summary

Summary: Organic compounds that contain phosphorus as an integral part of the molecule.

Top Publications

  1. ncbi Association of in utero organophosphate pesticide exposure and fetal growth and length of gestation in an agricultural population
    Brenda Eskenazi
    Center for Children s Environmental Health Research, School of Public Health, University of California Berkeley, 94720 7380, USA
    Environ Health Perspect 112:1116-24. 2004
  2. ncbi Pesticides and their metabolites in the homes and urine of farmworker children living in the Salinas Valley, CA
    Asa Bradman
    Center for Children s Environmental Health Research, School of Public Health, University of California, Berkeley, CA 94720 7380, USA
    J Expo Sci Environ Epidemiol 17:331-49. 2007
  3. ncbi A mass spectrometry-based method to measure dialkylphosphate degradation products of organophosphorous insecticides in dust and orange juice
    Gayanga Weerasekera
    National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Mailstop F 17, Atlanta, Georgia, USA
    J Environ Monit 11:1345-51. 2009
  4. ncbi Fotemustine as second-line treatment for recurrent or progressive glioblastoma after concomitant and/or adjuvant temozolomide: a phase II trial of Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO)
    Alba A Brandes
    Department of Medical Oncology, Ospedale Bellaria Maggiore, Bologna, Italy
    Cancer Chemother Pharmacol 64:769-75. 2009
  5. ncbi Intercalating nucleic acids containing insertions of 1-O-(1-pyrenylmethyl)glycerol: stabilisation of dsDNA and discrimination of DNA over RNA
    Ulf B Christensen
    Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, DK-5230 Odense M, Denmark
    Nucleic Acids Res 30:4918-25. 2002
  6. ncbi Urinary metabolite concentrations of organophosphorous pesticides, bisphenol A, and phthalates among pregnant women in Rotterdam, the Netherlands: the Generation R study
    Xibiao Ye
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, MD A3 05, PO Box 12233, Research Triangle Park, NC 27709, USA
    Environ Res 108:260-7. 2008
  7. ncbi The presence of dialkylphosphates in fresh fruit juices: implication for organophosphorus pesticide exposure and risk assessments
    C Lu
    Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    J Toxicol Environ Health A 68:209-27. 2005
  8. ncbi Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast
    Stuart A Ralph
    Institut Pasteur, Biology of Host-Parasite Interactions, 25 rue du Docteur Roux, 75724, Paris, Cedex 15, France
    Nat Rev Microbiol 2:203-16. 2004
  9. ncbi Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
    H Jomaa
    Institute of Biochemistry, Academic Hospital Centre, Justus Liebig University, Friedrichstrasse 24, D 35392 Giessen, Germany
    Science 285:1573-6. 1999
  10. ncbi Functionally relevant coronary artery disease: comparison of 64-section CT angiography with myocardial perfusion SPECT
    Oliver Gaemperli
    Cardiovascular Center, University Hospital Zurich, Ramistrasse 100, NUK C 32, CH 8091 Zurich, Switzerland
    Radiology 248:414-23. 2008

Research Grants

  1. Age and sex effects on nerve agent damage to the brain and antidotal therapies
    EDSON ALBUQUERQUE; Fiscal Year: 2007
  2. PEG-MODIFIED ENZYMES FOR IN-VIVO DECON OF OP TOXINS
    KEITH LEJEUNE; Fiscal Year: 2003
  3. H-Phosphinic Acids in the Preparation of Active Organophosphorus Compounds
    Jean Luc Montchamp; Fiscal Year: 2007
  4. fMRI Assessment of Organophosphate Neurotoxicity
    Steven Bird; Fiscal Year: 2007
  5. ENHANCING RADIATION THERAPY: VASCULAR TARGETING AGENTS
    Dietmar Siemann; Fiscal Year: 2007
  6. Combining Anti Angiogenesis Strategies and Radiotherapy
    Dietmar Siemann; Fiscal Year: 2005
  7. RADIATION AND DRUG EFFECTS ON TUMOR CELL SUBPOPULATIONS
    Dietmar Siemann; Fiscal Year: 2001
  8. Combining Anti-Angiogenesis Strategies and Radiotherapy
    Dietmar W Siemann; Fiscal Year: 2010
  9. DRUGS AND DEVELOPMENT OF ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 1980
  10. ETHANOL AND PHOSPHOINOSITIDES DURING BRAIN DEVELOPMENT
    LUCIO COSTA; Fiscal Year: 2000

Detail Information

Publications237 found, 100 shown here

  1. ncbi Association of in utero organophosphate pesticide exposure and fetal growth and length of gestation in an agricultural population
    Brenda Eskenazi
    Center for Children s Environmental Health Research, School of Public Health, University of California Berkeley, 94720 7380, USA
    Environ Health Perspect 112:1116-24. 2004
    ..However, despite these observed associations, the rate of preterm delivery in this population (6.4%) was lower than in a U.S. reference population...
  2. ncbi Pesticides and their metabolites in the homes and urine of farmworker children living in the Salinas Valley, CA
    Asa Bradman
    Center for Children s Environmental Health Research, School of Public Health, University of California, Berkeley, CA 94720 7380, USA
    J Expo Sci Environ Epidemiol 17:331-49. 2007
    ..The child activity timeline, a novel, low-literacy instrument based on pictures, was successfully used by our participants. Future uses of these data include the development of pesticide exposure models and risk assessment...
  3. ncbi A mass spectrometry-based method to measure dialkylphosphate degradation products of organophosphorous insecticides in dust and orange juice
    Gayanga Weerasekera
    National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Mailstop F 17, Atlanta, Georgia, USA
    J Environ Monit 11:1345-51. 2009
    ..Evaluation of the conversion of intact pesticides in the samples to DAPs will help us to better understand the contribution of preformed DAPs to urinary DAP concentrations...
  4. ncbi Fotemustine as second-line treatment for recurrent or progressive glioblastoma after concomitant and/or adjuvant temozolomide: a phase II trial of Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO)
    Alba A Brandes
    Department of Medical Oncology, Ospedale Bellaria Maggiore, Bologna, Italy
    Cancer Chemother Pharmacol 64:769-75. 2009
    ..Standardized salvage treatment has not yet proved effective in glioblastoma multiforme (GBM) patients who receive prior standard radiotherapy plus concomitant and adjuvant temozolomide...
  5. ncbi Intercalating nucleic acids containing insertions of 1-O-(1-pyrenylmethyl)glycerol: stabilisation of dsDNA and discrimination of DNA over RNA
    Ulf B Christensen
    Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, DK-5230 Odense M, Denmark
    Nucleic Acids Res 30:4918-25. 2002
    ..Fluorescence measurements show a stronger interaction of the pyrene moiety with DNA than with RNA, indicating intercalation as the stabilising factor in DNA/INA duplexes...
  6. ncbi Urinary metabolite concentrations of organophosphorous pesticides, bisphenol A, and phthalates among pregnant women in Rotterdam, the Netherlands: the Generation R study
    Xibiao Ye
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, MD A3 05, PO Box 12233, Research Triangle Park, NC 27709, USA
    Environ Res 108:260-7. 2008
    ..The data indicate that the Generation R study population provides a wide distribution of selected environmental exposures. Reasons for the relatively high levels and possible health effects need investigation...
  7. ncbi The presence of dialkylphosphates in fresh fruit juices: implication for organophosphorus pesticide exposure and risk assessments
    C Lu
    Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    J Toxicol Environ Health A 68:209-27. 2005
    ..In conclusion, urinary DAPs have many limitations when being used as biomarkers for OP pesticides in exposure and risk assessment, and caution should be exercised when interpreting DAPs results...
  8. ncbi Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast
    Stuart A Ralph
    Institut Pasteur, Biology of Host-Parasite Interactions, 25 rue du Docteur Roux, 75724, Paris, Cedex 15, France
    Nat Rev Microbiol 2:203-16. 2004
  9. ncbi Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
    H Jomaa
    Institute of Biochemistry, Academic Hospital Centre, Justus Liebig University, Friedrichstrasse 24, D 35392 Giessen, Germany
    Science 285:1573-6. 1999
    ..Both drugs suppressed the in vitro growth of multidrug-resistant P. falciparum strains. After therapy with these drugs, mice infected with the rodent malaria parasite P. vinckei were cured...
  10. ncbi Functionally relevant coronary artery disease: comparison of 64-section CT angiography with myocardial perfusion SPECT
    Oliver Gaemperli
    Cardiovascular Center, University Hospital Zurich, Ramistrasse 100, NUK C 32, CH 8091 Zurich, Switzerland
    Radiology 248:414-23. 2008
    ....
  11. ncbi Analysis of inhibition, reactivation and aging kinetics of highly toxic organophosphorus compounds with human and pig acetylcholinesterase
    N Aurbek
    Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937 Munich, Germany
    Toxicology 224:91-9. 2006
    b>Organophosphorus compounds (OP) are in wide spread use as pesticides and highly toxic OP may be used as chemical warfare agents (nerve agents)...
  12. ncbi Postillumination isoprene emission: in vivo measurements of dimethylallyldiphosphate pool size and isoprene synthase kinetics in aspen leaves
    Bahtijor Rasulov
    Department of Plant Physiology, University of Tartu, 51010 Tartu, Estonia
    Plant Physiol 149:1609-18. 2009
    ....
  13. ncbi Microbial degradation of organophosphorus compounds
    Brajesh K Singh
    Environmental Sciences, Macaulay Institute, Craigiebuckler, Aberdeen, UK
    FEMS Microbiol Rev 30:428-71. 2006
    Synthetic organophosphorus compounds are used as pesticides, plasticizers, air fuel ingredients and chemical warfare agents...
  14. ncbi NO-1886 upregulates ATP binding cassette transporter A1 and inhibits diet-induced atherosclerosis in Chinese Bama minipigs
    Chi Zhang
    Institute of Cardiovascular Research, Nanhua University Medical School, Hengyang, Hunan 421001, China
    J Lipid Res 47:2055-63. 2006
    ..These results demonstrate that the mechanism of atherosclerosis inhibition for NO-1886 is associated with its effect on ABCA1...
  15. ncbi NO-1886 decreases ectopic lipid deposition and protects pancreatic beta cells in diet-induced diabetic swine
    W Yin
    Department of Biochemistry and Biotechnology, Nanhua University School of Life Sciences and Technology, Hengyang, Hunan 421001, China
    J Endocrinol 180:399-408. 2004
    ..Therefore, NO-1886 is potentially beneficial for the treatment of insulin-resistance syndrome...
  16. ncbi Treatment of recurrent malignant gliomas with fotemustine monotherapy: impact of dose and correlation with MGMT promoter methylation
    Alessandra Fabi
    Division of Medical Oncology, Regina Elena Cancer Institute, Rome, Italy
    BMC Cancer 9:101. 2009
    ..Also, the impact of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status on fotemustine activity has never been explored in the clinical setting...
  17. ncbi High fidelity of base pairing by 2-selenothymidine in DNA
    Abdalla E A Hassan
    Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, USA
    J Am Chem Soc 132:2120-1. 2010
    ..Furthermore, this Se-atom-specific substitution and probing are useful for X-ray crystal structure and function studies of nucleic acids...
  18. ncbi Animal and human studies with the mitochondria-targeted antioxidant MitoQ
    Robin A J Smith
    Department of Chemistry, University of Otago, Dunedin, New Zealand
    Ann N Y Acad Sci 1201:96-103. 2010
    ..MitoQ has now been used in a range of in vivo studies in rats and mice and in two phase II human trials. Here, we review what has been learned from these animal and human studies with MitoQ...
  19. ncbi Hydrolysis of organophosphorus compounds by microbial enzymes
    Casey M Theriot
    Department of Microbiology, North Carolina State University, 4548 Thomas Hall, Campus Box 7615, Raleigh, NC 27695 7615, USA
    Appl Microbiol Biotechnol 89:35-43. 2011
    ..Current and future potential applications of these enzymes in the hydrolysis of OP compounds are also addressed...
  20. ncbi Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice
    Sergio Rodriguez-Cuenca
    Department of Clinical Biochemistry, University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Cambridge CB2 0QQ, UK
    Free Radic Biol Med 48:161-72. 2010
    ..Therefore, MitoQ does not act as a pro-oxidant in vivo. These findings indicate that mitochondria-targeted antioxidants can be safely administered long-term to wild-type mice...
  21. ncbi Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix
    Helena M Cocheme
    Medical Research Council Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK
    Cell Metab 13:340-50. 2011
    ..Our findings provide approaches to investigate mitochondrial ROS in vivo and suggest that while an increase in overall mitochondrial H(2)O(2) correlates with aging, it may not be causative...
  22. ncbi Functional genomic of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism
    Lucio G Costa
    Department of Environmental Health, University of Washington, Seattle, Washington 98195, USA
    Annu Rev Med 54:371-92. 2003
    ..A more recent area of investigation, the role of PON1 in drug metabolism, is also discussed. We emphasize the importance of considering both PON1 isoforms and PON1 levels in disease/sensitivity association studies...
  23. ncbi 5-Fluoro pyrimidines: labels to probe DNA and RNA secondary structures by 1D 19F NMR spectroscopy
    Barbara Puffer
    Institute of Organic Chemistry, Center for Molecular Biosciences CMBI, University of Innsbruck, 6020 Innsbruck, Austria, Laboratory of Organic Chemistry, ETH Zurich, 8093 Zurich, Switzerland and Max Perutz Laboratories, Vienna Biocenter, University of Vienna, 1030 Vienna, Austria
    Nucleic Acids Res 37:7728-40. 2009
    ..Furthermore, we developed a facile synthetic route towards 5-fluoro cytidine phosphoramidites that enables their convenient site-specific incorporation into oligonucleotides by solid-phase synthesis...
  24. ncbi Correspondence: preformed biomarkers in produce inflate human organophosphate exposure assessments
    Robert I Krieger
    Environ Health Perspect 111:A688-9; author reply A89-91. 2003
  25. ncbi Role of CD8(+) lymphocytes in control of simian immunodeficiency virus infection and resistance to rechallenge after transient early antiretroviral treatment
    J D Lifson
    Retroviral Pathogenesis Laboratory, AIDS Vaccine Program, SAIC Frederick, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    J Virol 75:10187-99. 2001
    ..The results help establish the underlying feasibility of efforts to develop vaccines for the prevention of AIDS, although the exact nature of the protective host responses involved remains to be elucidated...
  26. ncbi Acetylcholinesterase inhibition: does it explain the toxicity of organophosphorus compounds?
    Donald M Maxwell
    US Army Medical Research Institute of Chemical Defense, 3100 Ricketts Point Road, Aberdeen Proving Ground, MD 21010 5400, USA
    Arch Toxicol 80:756-60. 2006
    ....
  27. ncbi Rapid multiresidue determination of organochlorine and organophosphorus compounds in human serum by solid-phase extraction and gas chromatography coupled to tandem mass spectrometry
    E Pitarch
    Analytical Chemistry, Experimental Sciences Dept, University Jaume I, PO Box 8029 AP, , Spain
    Anal Bioanal Chem 376:189-97. 2003
    ..The method was applied to several serum samples obtained from farmers devoted to citrus crop production. Chlorpyrifos, HCB, p, p'-DDE and the higher chlorinated PCBs (153, 138 and 180) were the most frequently detected compounds...
  28. ncbi Pesticides and susceptible populations: people with butyrylcholinesterase genetic variants may be at risk
    O Lockridge
    University of Nebraska Medical Center, Eppley Institute, Omaha 68198 6805, USA
    Neurotoxicology 21:113-26. 2000
    ..More studies are needed to strengthen the hypothesis that people with genetic variants of BChE are at higher risk of intoxication from pesticides...
  29. ncbi Administration of 9-[2-(phosphonomethoxy)propyl]adenine (PMPA) for prevention of perinatal simian immunodeficiency virus infection in rhesus macaques
    K K Van Rompay
    California Regional Primate Research Center, University of California, Davis 95616, USA
    AIDS Res Hum Retroviruses 14:761-73. 1998
    ..Our data demonstrate that PMPA treatment can reduce perinatal SIV infection and suggest that similar strategies may also be effective against HIV...
  30. ncbi Organic diets significantly lower children's dietary exposure to organophosphorus pesticides
    Chensheng Lu
    Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    Environ Health Perspect 114:260-3. 2006
    ..To our knowledge, this is the first study to employ a longitudinal design with a dietary intervention to assess children's exposure to pesticides. It provides new and persuasive evidence of the effectiveness of this intervention...
  31. ncbi Dialkylphosphates (DAPs) in fruits and vegetables may confound biomonitoring in organophosphorus insecticide exposure and risk assessment
    Xiaofei Zhang
    Personal Chemical Exposure Program, Environmental Toxicology Graduate Program, and infoscientific com, Inc, Manassas, Virginia 20111, USA
    J Agric Food Chem 56:10638-45. 2008
    ..DAPs are more persistent in plants and produce at routinely measured levels than their parent OP insecticides...
  32. ncbi Metabolites of organophosphorous insecticides in urine specimens from inhabitants of a residential area
    U Heudorf
    Department of Environmental Medicine and Hygiene, Public Health Authorities of the City of Frankfurt am Main, Brachbarstr. 18-22, Frankfurt, D-60311, Germany
    Environ Res 86:80-7. 2001
    ..This observation calls for further investigation...
  33. ncbi Merging models and biomonitoring data to characterize sources and pathways of human exposure to organophosphorus pesticides in the Salinas Valley of California
    Thomas E McKone
    Lawrence Berkeley National Laboratory, Berkeley, California, Center for Children s Environmental Health Research, School of Public Health, University of California, Berkeley, California, USA
    Environ Sci Technol 41:3233-40. 2007
    ..These results show that mass-balance models can estimate exposures for OP pesticides within the range measured by biological monitoring...
  34. ncbi Detection of organophosphate flame retardants in furniture foam and U.S. house dust
    Heather M Stapleton
    Nicholas School of the Environment, Duke University, Durham, North Carolina, USA
    Environ Sci Technol 43:7490-5. 2009
    ..The high prevalence of these chemicals in foam and the high concentrations measured in dust (as high as 1.8 mg/g) warrant further studies to evaluate potential health effects from dust exposure, particularly for children...
  35. ncbi Preparation of ethylene gas and comparison of ethylene responses induced by ethylene, ACC, and ethephon
    Wei Zhang
    National Key Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
    Plant Physiol Biochem 48:45-53. 2010
    ..For laboratories that do not have an ethylene tank, ethylene gas can be easily prepared by a chemical approach without further purification...
  36. ncbi Histone deacetylase inhibitors: the anticancer, antimetastatic and antiangiogenic activities of AN-7 are superior to those of the clinically tested AN-9 (Pivanex)
    Nataly Tarasenko
    Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Beilinson Campus, Petach Tikva 49100, Israel
    Clin Exp Metastasis 25:703-16. 2008
    ..02). Both AN-7 and AN-9 exhibited antimetastatic and antiangiogenic activities by reducing vascularization, bFGF expression and HIF-1alpha. Yet, AN-7 was more potent than AN-9...
  37. ncbi Organophosphate exposures in the United States: a longitudinal analysis of incidents reported to poison centers
    Daniel L Sudakin
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon 97331 6502, USA
    J Toxicol Environ Health A 70:141-7. 2007
    ..The results of this investigation are consistent with other studies that have reported that regulatory restriction of access to pesticide formulations may have a significant impact on the number of human exposure incidents...
  38. ncbi The anticancer prodrugs of butyric acid AN-7 and AN-9, possess antiangiogenic properties
    Diana Blank Porat
    Felsenstein Center for Medical Research, Tel Aviv University Beilinson Campus, Petach Tikva 49100, Israel
    Cancer Lett 256:39-48. 2007
    ..Herein, we show that the anticancer activity of AN-7 and AN-9 can be attributed in part to their antiangiogenic activities suggesting potential therapeutic benefits for prostate cancer patients...
  39. ncbi Synthesis of 2'-O-methyl-RNAs incorporating a 3-deazaguanine, and UV melting and computational studies on its hybridization properties
    Kohji Seio
    Frontier Collaborative Research Center, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Japan
    Nucleic Acids Res 34:4324-34. 2006
    ..Computational studies based on ab initio calculations suggest that the weaker hydrogen bonding ability and larger dipole moment of c3G can be the origin of the lower T(m)...
  40. ncbi Derivatization of DNAs with selenium at 6-position of guanine for function and crystal structure studies
    Jozef Salon
    Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA
    Nucleic Acids Res 36:7009-18. 2008
    ..Furthermore, this novel selenium modification of nucleic acids can be used to investigate chemogenetics and structure of nucleic acids and their protein complexes...
  41. ncbi Assessment of organophosphorous pesticide exposures in the diets of preschool children in Washington State
    Richard A Fenske
    Department of Environmental Health, University of Washington, Box 357234, Seattle 98195 7234, USA
    J Expo Anal Environ Epidemiol 12:21-8. 2002
    ..7 microg/kg/day was exceeded by one subject during one sampling event. This subject's cumulative daily dose of chlorpyrifos equivalents was estimated to be 2.5 microg/kg/day...
  42. ncbi Solid phase microextraction using new sol-gel hybrid polydimethylsiloxane-2-hydroxymethyl-18-crown-6-coated fiber for determination of organophosphorous pesticides
    Wan Aini Wan Ibrahim
    Separation Science and Technology Group SepSTec, Ibnu Sina Institute for Fundamental Science Studies, Universiti Teknologi Malaysia, 81310 UTM Skudai, Johor Bahru, Johor, Malaysia
    J Chromatogr A 1217:4890-7. 2010
    ..Percentage recovery of OPPs from strawberry, green apple and grape samples with the new hybrid sol-gel SPME material ranged from 65 to 125% with good precision of the method (%RSD) ranging from 0.3 to 7.4%...
  43. ncbi A new schedule of fotemustine in temozolomide-pretreated patients with relapsing glioblastoma
    Raffaele Addeo
    Oncology Department, S Giovanni di Dio Hospital, ASL Napoli2 Nord Via Giovanni XXIII, 80028 Frattaminore, Naples, Italy
    J Neurooncol 102:417-24. 2011
    ..The study demonstrates that FTM has therapeutic efficacy as single-drug second-line chemotherapy with a favorable safety profile...
  44. ncbi Biomarker measurements of concurrent exposure to multiple environmental chemicals and chemical classes in children
    Ken Sexton
    Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Brownsville, Texas 78520, USA
    J Toxicol Environ Health A 74:927-42. 2011
    ..In addition, levels of cotinine in urine indicate that more than half the children were regularly exposed to environmental tobacco smoke, with the upper 10th percentile exposed to relatively high concentrations...
  45. ncbi Biosynthesis of terpenes: studies on 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase
    Petra Adam
    Lehrstuhl fur Organische Chemie und Biochemie, Technische Universitat Munchen, Lichtenbergstrasse 4, D 85747 Garching, Germany
    Proc Natl Acad Sci U S A 99:12108-13. 2002
    ..The low intrinsic catalytic activities of wild-type E. coli cell extract and isolated chromoplasts of red pepper (Capsicum annuum) are enhanced by the addition of purified recombinant IspH protein...
  46. ncbi New reconstruction algorithm allows shortened acquisition time for myocardial perfusion SPECT
    Ines Valenta
    Cardiac Imaging, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland
    Eur J Nucl Med Mol Imaging 37:750-7. 2010
    ..We aimed to validate a new iterative reconstruction (IR) algorithm for SPECT MPI allowing shortened acquisition time (HALF time) while maintaining image quality vs. standard full time acquisition (FULL time)...
  47. ncbi Photochemically induced RNA and DNA abasic sites
    Pascal A Küpfer
    Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland
    Nucleosides Nucleotides Nucleic Acids 26:1177-80. 2007
    ..Another building block which releases a 2'-O-methylated abasic site upon UV radiation is also described...
  48. ncbi Three-dimensional fusion of coronary arteries with myocardial perfusion distributions: clinical validation
    Tracy L Faber
    Department of Radiology, Emory University, Atlanta, Georgia 30322, USA
    J Nucl Med 45:745-53. 2004
    ..Myocardial mass at risk was used as a unique measure to validate the accuracy of the unification...
  49. ncbi Diagnostic accuracy of computed tomography coronary angiography and evaluation of stress-only single-photon emission computed tomography/computed tomography hybrid imaging: comparison of prospective electrocardiogram-triggering vs. retrospective gating
    Lars Husmann
    Cardiovascular Center, University Hospital Zurich, Zurich, Switzerland
    Eur Heart J 30:600-7. 2009
    ..retrospective ECG-gating...
  50. ncbi Intraocular properties of an alkoxyalkyl derivative of cyclic 9-(S)-(3-hydroxyl-2-phosphonomehoxypropyl) adenine, an intravitreally injectable anti-HCMV drug in rabbit and guinea pig
    Ajay M Tammewar
    Jacobs Retina Center at Shiley Eye Center, University of California San Diego Department of Ophthalmology, La Jolla, San Diego, CA 92037, USA
    J Ocul Pharmacol Ther 23:433-44. 2007
    ....
  51. ncbi Effects of NAAG peptidase inhibitor 2-PMPA in model chronic pain - relation to brain concentration
    Jens Nagel
    Preclinical R and D, Merz Pharmaceuticals GmbH, Eckenheimer Landstrasse 100, 60318 Frankfurt am Main, Germany
    Neuropharmacology 51:1163-71. 2006
    ..It appears therefore that the observed behavioural effects of 2-PMPA may not be mediated by NAAG nor, in turn, by mGluR3 receptors...
  52. ncbi A comparison of Tl-201, Tc-99m sestamibi, and Tc-99m tetrofosmin myocardial perfusion scintigraphy in patients with mild to moderate coronary stenosis
    Eliana Reyes
    National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Nucl Cardiol 13:488-94. 2006
    ..Thallium 201, technetium 99m sestamibi (MIBI), and Tc-99m tetrofosmin differ in their myocardial uptake characteristics. This may make the technetium tracers less sensitive for detecting mild to moderate coronary stenosis...
  53. ncbi Plant isoprenoid biosynthesis via the MEP pathway: in vivo IPP/DMAPP ratio produced by (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase in tobacco BY-2 cell cultures
    Denis Tritsch
    Universite de Strasbourg CNRS, Institut de Chimie UMR 7177, Strasbourg, France
    FEBS Lett 584:129-34. 2010
    ....
  54. ncbi Lipoprotein lipase activator NO-1886
    Weidong Yin
    Department of Biochemistry and Molecular Biology, Medical School, Nanhua University, Hengyang 421001, China
    Cardiovasc Drug Rev 21:133-42. 2003
    ..Therefore, the LPL activator NO-1886 or other possible LPL activating agents are potentially beneficial for the treatment of hypertriglyceridemia, hypo-HDL cholesterolemia, and protection from atherosclerosis...
  55. ncbi Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin
    Andrew C Hemmert
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3290, USA
    Mol Pharmacol 77:508-16. 2010
    ..These results provide important insights toward the long-term goal of designing novel forms of hCE1 to act as protein-based therapeutics for nerve agent detoxification...
  56. ncbi Clamping down on weak terminal base pairs: oligonucleotides with molecular caps as fidelity-enhancing elements at the 5'- and 3'-terminal residues
    Sukunath Narayanan
    Institute for Organic Chemistry, University of Karlsruhe (TH, D-76131 Karlsruhe, Germany
    Nucleic Acids Res 32:2901-11. 2004
    ..A doubly capped dodecamer thus prepared gives a melting point decrease for double-terminal mismatches that is 5.7-5.9 degrees C greater than that for the unmodified control duplex...
  57. ncbi Red blood cell acetylcholinesterase and plasma butyrylcholinesterase status: important indicators for the treatment of patients poisoned by organophosphorus compounds
    Horst Thiermann
    Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany
    Arh Hig Rada Toksikol 58:359-66. 2007
    Inhibition of acetylcholinesterase (AChE) is regarded as the primary toxic mechanism of organophosphorus compounds (OP)...
  58. ncbi Rapid simultaneous determination for organophosphorus pesticides in human serum by LC-MS
    Shigeaki Inoue
    Department of Emergency and Critical Care Medicine, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    J Pharm Biomed Anal 44:258-64. 2007
    ..In terms of temperature stability, of all the organophosphorus compounds analyzed, dichlorvos and malathion exhibited the most rapid degradations over 24h at room temperature...
  59. ncbi Focus on Fotemustine
    A De Rossi
    Department of Neuroscience, University of Rome Tor Vergata, Italy
    J Exp Clin Cancer Res 25:461-8. 2006
    ..Therefore, it is reasonable to assume that this agent could be a good candidate to play a potential role in haematological malignancies...
  60. ncbi Inhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats: a NAAG-mGluR2/3-mediated mechanism
    Zheng Xiong Xi
    Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
    J Neurochem 112:564-76. 2010
    ..These findings suggest that 2-PMPA is effective in attenuating cocaine-induced reinstatement of drug-seeking behavior, likely by attenuating cocaine-induced increases in NAc DA and glutamate via pre-synaptic mGluR2/3s...
  61. ncbi Feasibility and diagnostic accuracy of a gated SPECT early-imaging protocol: a multicenter study of the Myoview Imaging Optimization Group
    Assuero Giorgetti
    CNR Institute of Clinical Physiology, Pisa, Italy
    J Nucl Med 48:1670-5. 2007
    ..The aim of this study was to investigate whether early (time 1, or T1) myocardial tetrofosmin imaging is feasible and as accurate in detecting coronary artery disease as is standard delayed (time 2, or T2) imaging...
  62. ncbi NO-1886 suppresses diet-induced insulin resistance and cholesterol accumulation through STAT5-dependent upregulation of IGF1 and CYP7A1
    Qinkai Li
    Key Laboratory for Atherosclerology of Hunan Province, Institute of Cardiovascular Research, Life Science Research Center, University of South China, Hengyang, Hunan 421001, People s Republic of China
    J Endocrinol 204:47-56. 2010
    ....
  63. ncbi A multi-institutional phase II study on second-line Fotemustine chemotherapy in recurrent glioblastoma
    Maria Grazia Fabrini
    Radiotherapy Division of Pisa University Hospital, Pisa, Italy
    J Neurooncol 92:79-86. 2009
    ..1 months; PFS-6 was 52% and median overall survival from primary diagnosis was 24.5 months, with few manageable haematological toxicities. Fotemustine was safe and effective as second-line chemotherapy in recurrent glioblastoma...
  64. ncbi GS-9219--a novel acyclic nucleotide analogue with potent antineoplastic activity in dogs with spontaneous non-Hodgkin's lymphoma
    Hans Reiser
    Department of Research and Development, Gilead Sciences, Inc, Foster City, California 94404, USA
    Clin Cancer Res 14:2824-32. 2008
    ..Our objective was to characterize the antiproliferative activity, pharmacokinetics, pharmacodynamics, and safety of GS-9219...
  65. ncbi Chronic organophosphate (OP)-induced neuropsychiatric disorder is a withdrawal syndrome
    De Hong Tan
    Evaluation and Research Center for Toxicology, Institute of Disease Control and Prevention, Academy of Military Medical Sciences, 20 Dong Da Jie Street, Fengtai District, Beijing 100071, PR China
    Med Hypotheses 72:405-6. 2009
    ....
  66. ncbi Acetal levulinyl ester (ALE) groups for 2'-hydroxyl protection of ribonucleosides in the synthesis of oligoribonucleotides on glass and microarrays
    Jeremy G Lackey
    Department of Chemistry, McGill University, Montreal, Quebec, Canada H3A 2K6
    J Am Chem Soc 131:8496-502. 2009
    ..The chemistry and methods described here pave the way to the fabrication of microarrays of immobilized RNA probes for analyzing molecular interactions of biological interest...
  67. ncbi Biotransformation of organophosphorus compounds
    M Jokanovic
    Department of Toxicology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11000, Belgrade, Yugoslavia
    Toxicology 166:139-60. 2001
    This study reviews current understanding of mechanisms of biotransformation of organophosphorus compounds (OPC)...
  68. ncbi Early post-stress pulmonary uptake of 99mTc tetrofosmin during exercise (SPECT) myocardial perfusion imaging: correlation with haemodynamic, perfusion and function parameters
    Panagiotis Georgoulias
    Department of Nuclear Medicine, University Hospital of Larissa, Greece
    Nucl Med Commun 27:119-26. 2006
    ..To test the association of early post-stress lung/heart ratio (LHR) of 99mTc tetrofosmin radioactivity with gated-SPECT findings and angiographic results...
  69. ncbi Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase
    Cynthia Gilley
    Human BioMolecular Research Institute, San Diego, California 92121, USA
    Chem Res Toxicol 22:1680-8. 2009
    ..However, the soman and sarin thiomethyl compounds yielded two types of adducts, one of which was thiomethyl phosphonate, a modification not found after treatment with authentic soman and sarin...
  70. ncbi Kinetic analysis of the protection afforded by reversible inhibitors against irreversible inhibition of acetylcholinesterase by highly toxic organophosphorus compounds
    Saskia Eckert
    Walther-Straub-Institute of Pharmacology and Toxicology, Ludwig-Maximilians-University of Munich, Goethestr. 33, D-80336 Munich, Germany
    Biochem Pharmacol 72:344-57. 2006
    ..The model predicts that inhibitors with a faster dissociation rate, e.g. huperzine A, may be superior in case of a 'hit-and-run' poison such as soman...
  71. ncbi Activity of a new vascular targeting agent, ZD6126, in pulmonary metastases by human lung adenocarcinoma in nude mice
    Hisatsugu Goto
    Department of Internal Medicine and Molecular Therapeutics, Course of Medical Oncology, The University of Tokushima School of Medicine, Tokushima 770-8503, Japan
    Cancer Res 62:3711-5. 2002
    ....
  72. ncbi Effect of 2-(phosphono-methyl)-pentanedioic acid on allodynia and afferent ectopic discharges in a rat model of neuropathic pain
    Shao-Rui Chen
    Department of Anesthesiology, Penn State University College of Medicine, Hershey, Pennsylvania 17033-0850, USA
    J Pharmacol Exp Ther 300:662-7. 2002
    ..Therefore, these data suggest that the antiallodynic effect of 2-PMPA may be mediated, at least in part, by inhibition of ectopic afferent discharges at the site of nerve injury...
  73. ncbi Charge migration in DNA: ion-gated transport
    R N Barnett
    School of Physics, School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Science 294:567-71. 2001
    ..This reduction indicates a reduced mobility of the hole across the modified bridge as predicted theoretically...
  74. ncbi Dietary intake and its contribution to longitudinal organophosphorus pesticide exposure in urban/suburban children
    Chensheng Lu
    Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    Environ Health Perspect 116:537-42. 2008
    ..Because such exposure may cause adverse health effects, particularly in children, the sources and patterns of exposure need to be studied further...
  75. ncbi Analysis of 3,5,6-trichloro-2-pyridinol in urine samples from the general population using gas chromatography-mass spectrometry after steam distillation and solid-phase extraction
    H M Koch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen-Nuremberg, Erlangen, Germany
    J Chromatogr B Biomed Sci Appl 759:43-9. 2001
    ..Four urine samples collected from workers who had applied chlorpyrifos were also analysed. In these samples TCPyr was found in concentrations from 4.7 to 7.9 microg/l...
  76. ncbi Antitumor activity of ZD6126, a novel vascular-targeting agent, is enhanced when combined with ZD1839, an epidermal growth factor receptor tyrosine kinase inhibitor, and potentiates the effects of radiation in a human non-small cell lung cancer xenograft
    David Raben
    Department of Radiation Oncology, University of Colorado Health Sciences Center, Anschutz Cancer Pavilion, 1665 North Ursula Street, Suite 1032, Box F706, Aurora, CO 80010 0510, USA
    Mol Cancer Ther 3:977-83. 2004
    ....
  77. ncbi Single dose of the antivascular agent, ZD6126 (N-acetylcolchinol-O-phosphate), reduces perfusion for at least 96 hours in the GH3 prolactinoma rat tumor model
    Dominick J O McIntyre
    Department of Basic Medical Sciences, St George s Hospital Medical School, Tooting, London, UK
    Neoplasia 6:150-7. 2004
    ....
  78. ncbi In vivo tumor transfection mediated by polyplexes based on biodegradable poly(DMAEA)-phosphazene
    Holger K de Wolf
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS, Utrecht University, The Netherlands
    J Control Release 109:275-87. 2005
    ..The observed preferential tumor gene expression mediated by the p(DMAEA)-ppz polyplexes enables the application of this polymer to deliver therapeutic genes to tumors...
  79. ncbi A mechanism for organophosphate-induced delayed neuropathy
    Paul Glynn
    MRC Toxicology Unit, University of Leicester, Leicester LE1 9HN, UK
    Toxicol Lett 162:94-7. 2006
    ....
  80. ncbi Alkylamines cause Vgamma9Vdelta2 T-cell activation and proliferation by inhibiting the mevalonate pathway
    Keith Thompson
    Bone Research Group, Department of Medicine and Therapeutics, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, AB25 2ZD, United Kingdom
    Blood 107:651-4. 2006
    ....
  81. ncbi The effects of fresh frozen plasma on cholinesterase levels and outcomes in patients with organophosphate poisoning
    Muhammet Guven
    Department of Intensive Care, Faculty of Medicine, Erciyes University Medical School, 38039, Kayseri, Turkey
    J Toxicol Clin Toxicol 42:617-23. 2004
    ..The aim of this study is to determine the effects of fresh frozen plasma, as a source of cholinesterase, on butyrylcholinesterase (BuChE; plasma or pseudo cholinesterase) levels and outcomes in patients with organophosphate poisoning...
  82. ncbi Biological monitoring of exposure to organophosphorus insecticides in a group of horticultural greenhouse workers
    Michèle Bouchard
    Chaire en Analyse des Risques Toxicologiques Pour la Santé Humaine and Département de Santé Environnementale et Santé au Travail, Faculté de Médecine Université de Montréal, Succursale Centre Ville, Montreal, Quebec, Canada
    Ann Occup Hyg 50:505-15. 2006
    ..These results question the relevance of measuring non-specific phosphoric metabolites when attempting to assess low-dose occupational exposure to a specific OP...
  83. ncbi Identification of acylpeptide hydrolase as a sensitive site for reaction with organophosphorus compounds and a potential target for cognitive enhancing drugs
    P G Richards
    Medical Research Council Toxicology Unit, University of Leicester, Leicester, United Kingdom
    Mol Pharmacol 58:577-83. 2000
    We describe here the purification and identification of a previously unrecognized target for organophosphorus compounds. The target, acylpeptide hydrolase, was isolated as a tritiated-diisopropylfluorophosphate-reactive protein from ..
  84. ncbi Management of acute organophosphorus pesticide poisoning
    Michael Eddleston
    Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, England
    Lancet 371:597-607. 2008
    ..Improved medical management of organophosphorus poisoning should result in a reduction in worldwide deaths from suicide...
  85. ncbi Overcoming apathy in research on organophosphate poisoning
    Nick A Buckley
    South Asian Clinical Toxicology Research Collaboration, Department of Clinical Pharmacology and Toxicology, Canberra Hospital, PO Box 11, Woden, ACT 2606, Australia
    BMJ 329:1231-3. 2004
  86. ncbi Water-soluble biodegradable cationic polyphosphazenes for gene delivery
    J Luten
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
    J Control Release 89:483-97. 2003
    ..5 and 37 degrees C was around 7 days for poly(DMAE)phosphazenes and 24 days for poly(DMAEA)phosphazenes. This study shows that polyphosphazenes are a suitable and promising new class of biodegradable polymeric carriers for gene delivery...
  87. ncbi Diazepam inhibits organophosphate-induced central respiratory depression
    Eric W Dickson
    Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Acad Emerg Med 10:1303-6. 2003
    ..However, the exact mechanism of OP-induced CRD is unknown. In these studies, the authors investigated the hypothesis that OP-induced CRD is the result of overstimulation of CNS respiratory centers...
  88. ncbi Plasma cholinesterase levels and health symptoms in peruvian farm workers exposed to organophosphate pesticides
    Hector C Cataño
    Laboratorio de Biologia Molecular, Instituto de Quimica Biologica, Microbiología y Biotecnología, Facultad de Farmacia y Bioquimica, Universidad Nacional Mayor de San Marcos, Jr Puno 1002, Jardín Botánico, Lima 1, Peru
    Arch Environ Contam Toxicol 55:153-9. 2008
    ..The use of correct PPE is highly recommended...
  89. ncbi Semen quality in Peruvian pesticide applicators: association between urinary organophosphate metabolites and semen parameters
    Sandra Yucra
    Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru
    Environ Health 7:59. 2008
    ..We performed a cross-sectional study of associations between dialkylphosphate metabolites of organophosphates and semen quality among pesticide applicators in Majes (Arequipa), Peru...
  90. ncbi Picolylamine-methylphosphonic acid esters as tridentate ligands for the labeling of alcohols with the fac-[M(CO)3]+ core (M = 99mTc, Re): synthesis and biodistribution of model compounds and of a 99mTc-labeled cobinamide
    Stefan Mundwiler
    Institute of Inorganic Chemistry, , Switzerland
    Nucl Med Biol 32:473-84. 2005
    ..Biodistribution studies in mice with B(16) melanoma exhibited fast clearance with no specific tissue binding...
  91. ncbi Evaluation of a freeze-dried kit for EDTMP-based bone-seeking radiopharmaceuticals
    Piotr Garnuszek
    Department of Radiopharmaceuticals, National Institute of Public Health, 30/34 Chelmska St, 00-725, Warsaw, Poland. pg.il.waw.pl
    Appl Radiat Isot 58:481-8. 2003
    ..g., investigation of bone metastases or ossification processes in inflammatory spondyloarthropathy...
  92. ncbi Esterification of cidofovir with alkoxyalkanols increases oral bioavailability and diminishes drug accumulation in kidney
    Stephanie L Ciesla
    Department of Medicine (0676, San Diego VA Healthcare System, University of California, San Diego, 305 Stein Clinical Research Building, 9500 Gilman Drive, La Jolla, CA 92093-0676, USA
    Antiviral Res 59:163-71. 2003
    ..Thus, the compounds are good candidates for further development for prevention and treatment of smallpox infection and the complications of vaccination...
  93. ncbi Increased antiviral activity of 1-O-hexadecyloxypropyl-[2-(14)C]cidofovir in MRC-5 human lung fibroblasts is explained by unique cellular uptake and metabolism
    Kathy A Aldern
    Department of Medicine, San Diego VA Healthcare System, San Diego, La Jolla, California, USA
    Mol Pharmacol 63:678-81. 2003
    ..7 days reported when cells are exposed to CDV. HDP-CDV seems to circumvent poor cellular uptake by rapid association with cellular membrane phospholipids, whereas CDV uptake proceeds via the slow process of fluid endocytosis...
  94. ncbi Preparation and biological evaluation of 153Sm-DOTMP as a potential agent for bone pain palliation
    Sudipta Chakraborty
    Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, India
    Nucl Med Commun 25:1169-76. 2004
    ..No leaching of skeletal activity was observed up to 48 h post-injection. Scintigraphic studies carried out in rabbits also showed significant skeletal accumulation and almost no retention of activity in other vital organs/tissues...
  95. ncbi The usefulness of 99mTc-tetrofosmin SPECT in the detection of intrathoracic malignant lesions
    Angela Spanu
    Department of Nuclear Medicine, University of Sassari, Sassari I-07100, Italy
    Int J Oncol 22:639-49. 2003
    ....
  96. ncbi Technetium-99m-tetrofosmin scintigraphy in the prediction of chemotherapy response of untreated malignant lymphomas and comparison with other prognostic factors
    S S Sun
    Department of Nuclear Medicine, China Medical College Hospital, Taichung, Taiwan
    Anticancer Res 21:685-8. 2001
    ..When compared with other prognostic factors, Tc-TF scintigraphy was the tool to predict the chemotherapy response of ML patients...
  97. ncbi Normalization of abnormal T-waves during stress testing does not identify patients with reversible perfusion defects
    Henry S Loeb
    Department of Cardiology, Edward Hines Jr Veterans Affairs Hospital, Hines, Illinois 60141, USA
    Clin Cardiol 30:403-7. 2007
    ..To determine if T-wave normalization during exercise or dobutamine stress testing identified patients with myocardial ischemia as indicated by reversible perfusion defects...
  98. ncbi The accuracy of 1-day dual-isotope myocardial SPECT in a population with high prevalence of coronary artery disease
    Reginald G E J Groutars
    Department of Cardiology, University Hospital, Leiden, The Netherlands
    Int J Cardiovasc Imaging 19:229-38. 2003
    ..Specific clinical issues caused a low value for specificity. Therefore, clinical information and knowledge of the electrocardiogram is essential for a correct interpretation of SPECT images...
  99. ncbi Electrophysiological and arrhythmogenic effects of intramyocardial bone marrow cell injection in patients with chronic ischemic heart disease
    Saskia L M A Beeres
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Heart Rhythm 4:257-65. 2007
    ..Bone marrow cell injection has been introduced to treat patients with ischemic heart disease. However, focal application of bone marrow cells may generate an arrhythmogenic substrate...
  100. ncbi Evaluation of cardiovascular complications with 99mTc tetrofosmin gated myocardial perfusion scintigraphy in patients with thalassemia major
    G K Gedik
    Department of Nuclear Medicine Hacettepe University Faculty of Medicine Ankara Turkey
    Rev Esp Med Nucl 27:191-8. 2008
    ..The aim of this study was to evaluate the role of (99m)Tc Tetrofosmin gated myocardial perfusion scintigraphy (GMPS) in the detection of cardiac dysfunction in patients with thalassemia major...
  101. ncbi Diagnostic and prognostic value of 99mTc-tetrofosmin scintigraphy in maxillofacial flaps
    Reingard M Aigner
    Department of Radiology, Division of Nuclear Medicine, Karl Franzens University Graz, Auenbruggerplatz 9, 8036 Graz, Austria
    Eur J Nucl Med Mol Imaging 30:197-201. 2003
    ..Therefore tetrofosmin scintigraphy is an important modality in order (a) to define the optimal therapeutic regimen in the immediate postoperative period and (b) to provide better prognosis...

Research Grants155 found, 100 shown here

  1. Age and sex effects on nerve agent damage to the brain and antidotal therapies
    EDSON ALBUQUERQUE; Fiscal Year: 2007
    The nerve agents soman, sarin and VX are organophosphorus compounds (OPs) chemically related to, but far more toxic than OP insecticides...
  2. PEG-MODIFIED ENZYMES FOR IN-VIVO DECON OF OP TOXINS
    KEITH LEJEUNE; Fiscal Year: 2003
    ..Several known enzymes exhibit hydrolytic activity on target organophosphorus compounds including nerve agent chemical weapons such as sarin and soman as well as many commercially available ..
  3. H-Phosphinic Acids in the Preparation of Active Organophosphorus Compounds
    Jean Luc Montchamp; Fiscal Year: 2007
    ..Thus, beyond the scope of this proposal, some of the chemistry detailed therein should make a significant contribution to the realm of phosphorus-based medicinal chemistry in general. ..
  4. fMRI Assessment of Organophosphate Neurotoxicity
    Steven Bird; Fiscal Year: 2007
    ..aims of this investigation focus on characterizing the central nervous system physiologic effects of organophosphorus compounds. The candidate has chosen Dr. Craig F. Ferris Ph.D. as a mentor for this project...
  5. ENHANCING RADIATION THERAPY: VASCULAR TARGETING AGENTS
    Dietmar Siemann; Fiscal Year: 2007
    ....
  6. Combining Anti Angiogenesis Strategies and Radiotherapy
    Dietmar Siemann; Fiscal Year: 2005
    ..We believe that these studies will provide essential insights into the therapeutic utility of employing antiangiogenic treatment strategies as adjuvants to radiotherapy. ..
  7. RADIATION AND DRUG EFFECTS ON TUMOR CELL SUBPOPULATIONS
    Dietmar Siemann; Fiscal Year: 2001
    ..Ultimately we hope that these approaches can be reliably developed to an extent where the use of human tumor biopsy material may lead to radiotherapy treatments more tailored to the individual patient. ..
  8. Combining Anti-Angiogenesis Strategies and Radiotherapy
    Dietmar W Siemann; Fiscal Year: 2010
    ..Experiments are designed to investigate the mechanisms underlying the interaction between such therapies and to develop approaches that would maximize the anti-tumor efficacy of such combined treatments. ..
  9. DRUGS AND DEVELOPMENT OF ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 1980
    ....
  10. ETHANOL AND PHOSPHOINOSITIDES DURING BRAIN DEVELOPMENT
    LUCIO COSTA; Fiscal Year: 2000
    ..2. To investigate the molecular pathways involved in the observed inhibition by ethanol of the mitogenic action of acetylcholine in astrocytes. ..
  11. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 1992
    ....
  12. Vulnerability to Opioids: A Mouse Model
    Wouter Koek; Fiscal Year: 2010
    ....
  13. ENHANCING RADIATION THERAPY: VASCULAR TARGETING AGENTS
    Dietmar W Siemann; Fiscal Year: 2010
    ..Experiments are designed to investigate how to deliver such therapies for maximum antitumor efficacy as well as determining the potential of developing predictive indicators of their treatment response. ..
  14. Discriminative Stimulus Effects of Alcohol in Mice
    Wouter Koek; Fiscal Year: 2007
    ..This future research will increase our understanding of risk factors for alcoholism and drug abuse and will help the development of effective approaches to prevention and treatment. ..
  15. Developmental neurotoxicity of ethanol
    LUCIO COSTA; Fiscal Year: 2009
    ..Altogether, these studies are aimed at elucidating novel aspects of the communication between astrocytes and neurons and at characterizing new mechanisms involved in the developmental neurotoxicity of ethanol. ..
  16. Neuropharmacology of GHB discrimination
    Wouter Koek; Fiscal Year: 2005
    ..By identifying the role of specific receptors in abuse-related effects of GHB, future studies may be better able to develop specific, pharmacologically targeted therapies for GHB abuse. ..
  17. Neuropharmacology of GHB discrimination
    Wouter Koek; Fiscal Year: 2010
    ..Increased knowledge about the activation and modulation of GABAB systems will help to develop effective approaches to treating sleep-, drug abuse-, and other CNS disorders. ..
  18. Fetal & Adolescent Nicotine Effects on CNS 5HT Systems
    Theodore Slotkin; Fiscal Year: 2003
    ..abstract_text> ..
  19. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 2003
    ....