organophosphorus compounds

Summary

Summary: Organic compounds that contain phosphorus as an integral part of the molecule.

Top Publications

  1. ncbi Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties
    G F Kelso
    Departments of Chemistry and Biochemistry, University of Otago, Box 56, Dunedin, New Zealand
    J Biol Chem 276:4588-96. 2001
  2. pmc Organophosphate pesticide exposure and attention in young Mexican-American children: the CHAMACOS study
    Amy R Marks
    Center for Children s Environmental Health Research, School of Public Health, University of California, Berkeley, Berkeley, California 94720, USA
    Environ Health Perspect 118:1768-74. 2010
  3. ncbi Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix
    Helena M Cocheme
    Medical Research Council Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK
    Cell Metab 13:340-50. 2011
  4. pmc Isoprenoid biosynthesis: the evolution of two ancient and distinct pathways across genomes
    B M Lange
    Institute of Biological Chemistry, Washington State University, Pullman, WA 99164 6340, USA
    Proc Natl Acad Sci U S A 97:13172-7. 2000
  5. ncbi A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease
    Barry J Snow
    Neurology Department, Auckland Hospital, Auckland, New Zealand
    Mov Disord 25:1670-4. 2010
  6. pmc Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia-reperfusion: therapeutic potential of mitochondrially targeted antioxidants
    Partha Mukhopadhyay
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Free Radic Biol Med 53:1123-38. 2012
  7. pmc Fotemustine as second-line treatment for recurrent or progressive glioblastoma after concomitant and/or adjuvant temozolomide: a phase II trial of Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO)
    Alba A Brandes
    Department of Medical Oncology, Ospedale Bellaria Maggiore, Bologna, Italy
    Cancer Chemother Pharmacol 64:769-75. 2009
  8. ncbi Second-line chemotherapy with fotemustine in temozolomide-pretreated patients with relapsing glioblastoma: a single institution experience
    Silvia Scoccianti
    Department of Radiotherapy, AOU Careggi, University of Florence, Florence, Italy
    Anticancer Drugs 19:613-20. 2008
  9. ncbi Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology
    M F Ross
    MRC Dunn Human Nutrition Unit, Cambridge, CB2 2XY, UK
    Biochemistry (Mosc) 70:222-30. 2005
  10. ncbi Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury
    Victoria J Adlam
    Department of Chemistry, University of Otago, Dunedin, New Zealand
    FASEB J 19:1088-95. 2005

Detail Information

Publications315 found, 100 shown here

  1. ncbi Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties
    G F Kelso
    Departments of Chemistry and Biochemistry, University of Otago, Box 56, Dunedin, New Zealand
    J Biol Chem 276:4588-96. 2001
    ..This approach will have further applications in investigating mitochondrial dysfunction in a range of experimental models...
  2. pmc Organophosphate pesticide exposure and attention in young Mexican-American children: the CHAMACOS study
    Amy R Marks
    Center for Children s Environmental Health Research, School of Public Health, University of California, Berkeley, Berkeley, California 94720, USA
    Environ Health Perspect 118:1768-74. 2010
    ..Exposure to organophosphate (OP) pesticides, well-known neurotoxicants, has been associated with neurobehavioral deficits in children...
  3. ncbi Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix
    Helena M Cocheme
    Medical Research Council Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK
    Cell Metab 13:340-50. 2011
    ..Our findings provide approaches to investigate mitochondrial ROS in vivo and suggest that while an increase in overall mitochondrial H(2)O(2) correlates with aging, it may not be causative...
  4. pmc Isoprenoid biosynthesis: the evolution of two ancient and distinct pathways across genomes
    B M Lange
    Institute of Biological Chemistry, Washington State University, Pullman, WA 99164 6340, USA
    Proc Natl Acad Sci U S A 97:13172-7. 2000
    ..The results suggest that lateral gene transfer between eubacteria subsequent to the origin of plastids has played a major role in the evolution of this pathway...
  5. ncbi A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease
    Barry J Snow
    Neurology Department, Auckland Hospital, Auckland, New Zealand
    Mov Disord 25:1670-4. 2010
    ..MitoQ does not slow the progression of PD, and this finding should be taken into account when considering the oxidative stress hypothesis for the pathogenesis of PD...
  6. pmc Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia-reperfusion: therapeutic potential of mitochondrially targeted antioxidants
    Partha Mukhopadhyay
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Free Radic Biol Med 53:1123-38. 2012
    ..Mitochondrially generated oxidants play a central role in triggering the deleterious cascade of events associated with hepatic I/R, which may be targeted by novel antioxidants for therapeutic advantage...
  7. pmc Fotemustine as second-line treatment for recurrent or progressive glioblastoma after concomitant and/or adjuvant temozolomide: a phase II trial of Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO)
    Alba A Brandes
    Department of Medical Oncology, Ospedale Bellaria Maggiore, Bologna, Italy
    Cancer Chemother Pharmacol 64:769-75. 2009
    ..Standardized salvage treatment has not yet proved effective in glioblastoma multiforme (GBM) patients who receive prior standard radiotherapy plus concomitant and adjuvant temozolomide...
  8. ncbi Second-line chemotherapy with fotemustine in temozolomide-pretreated patients with relapsing glioblastoma: a single institution experience
    Silvia Scoccianti
    Department of Radiotherapy, AOU Careggi, University of Florence, Florence, Italy
    Anticancer Drugs 19:613-20. 2008
    ..Fotemustine has shown therapeutic efficacy as single-drug second-line chemotherapy in treatment of TMZ pretreated patients...
  9. ncbi Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology
    M F Ross
    MRC Dunn Human Nutrition Unit, Cambridge, CB2 2XY, UK
    Biochemistry (Mosc) 70:222-30. 2005
    ..Here we review why these molecules are useful in mitochondrial research and outline some of the ways in which they are now being utilized...
  10. ncbi Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury
    Victoria J Adlam
    Department of Chemistry, University of Otago, Dunedin, New Zealand
    FASEB J 19:1088-95. 2005
    ....
  11. ncbi A multi-institutional phase II study on second-line Fotemustine chemotherapy in recurrent glioblastoma
    Maria Grazia Fabrini
    Radiotherapy Division of Pisa University Hospital, Pisa, Italy
    J Neurooncol 92:79-86. 2009
    ..1 months; PFS-6 was 52% and median overall survival from primary diagnosis was 24.5 months, with few manageable haematological toxicities. Fotemustine was safe and effective as second-line chemotherapy in recurrent glioblastoma...
  12. ncbi The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide-peptidoglycan model of sepsis
    Damon A Lowes
    Academic Unit of Anaesthesia and Intensive Care, School of Medicine, Institute of Medical Sciences, Foresterhill, Aberdeen, UK
    Free Radic Biol Med 45:1559-65. 2008
    ..05), and mitochondrial membrane potential was augmented (P<0.01) in most organs. These findings suggest that the use of mitochondria-targeted antioxidants such as MitoQ may be beneficial in sepsis...
  13. ncbi The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients
    Edward J Gane
    Liver Transplant Unit, Auckland City Hospital, Auckland, New Zealand
    Liver Int 30:1019-26. 2010
    ..The mitochondria-targeted anti-oxidant mitoquinone combines a potent anti-oxidant with a lipophilic cation that causes it to accumulate several-hundred fold within mitochondria in vivo...
  14. ncbi Biological monitoring of exposure to organophosphorus insecticides in a group of horticultural greenhouse workers
    Michèle Bouchard
    Chaire en Analyse des Risques Toxicologiques Pour la Santé Humaine and Département de Santé Environnementale et Santé au Travail, Faculté de Médecine Université de Montréal, Succursale Centre Ville, Montreal, Quebec, Canada
    Ann Occup Hyg 50:505-15. 2006
    ..These results question the relevance of measuring non-specific phosphoric metabolites when attempting to assess low-dose occupational exposure to a specific OP...
  15. pmc A new schedule of fotemustine in temozolomide-pretreated patients with relapsing glioblastoma
    Raffaele Addeo
    Oncology Department, S Giovanni di Dio Hospital, ASL Napoli2 Nord Via Giovanni XXIII, 80028 Frattaminore, Naples, Italy
    J Neurooncol 102:417-24. 2011
    ..The study demonstrates that FTM has therapeutic efficacy as single-drug second-line chemotherapy with a favorable safety profile...
  16. ncbi Organophosphate-induced delayed polyneuropathy
    Marcello Lotti
    Department of Environmental Medicine and Public Health, University of Padua, Padova, Italy
    Toxicol Rev 24:37-49. 2005
    ..Finally, several observational studies on long-term, low-level exposures to OPs that sometimes reported mild, inconsistent and unexplained changes of unclear significance in peripheral nerves are briefly discussed...
  17. pmc Selective uncoupling of individual mitochondria within a cell using a mitochondria-targeted photoactivated protonophore
    Susan Chalmers
    Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK
    J Am Chem Soc 134:758-61. 2012
    ..This also provides a proof of principle for the general temporally and spatially controlled release of bioactive molecules, pharmacophores, or toxins to mitochondria with tissue, cell, or mitochondrion specificity...
  18. pmc Analysis of the flame retardant metabolites bis(1,3-dichloro-2-propyl) phosphate (BDCPP) and diphenyl phosphate (DPP) in urine using liquid chromatography-tandem mass spectrometry
    E M Cooper
    Nicholas School of the Environment, Duke University, Durham, NC 27708, USA
    Anal Bioanal Chem 401:2123-32. 2011
    ..The presented method is simple and sufficiently sensitive to detect these FR metabolites in humans and may be applied to future studies to increase our understanding of exposure to and potential health effects from FRs...
  19. ncbi Analytical developments and preliminary assessment of human exposure to organophosphate flame retardants from indoor dust
    Nele Van den Eede
    Toxicological Center, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk Antwerp, Belgium
    Environ Int 37:454-61. 2011
    ..Exposure of non-working and working adults to OPFRs appeared to be similar, but in specific work environments, exposure to some OPFRs (e.g. TDCPP) was increased by a factor >5...
  20. ncbi 99mTc-N-DBODC5, a new myocardial perfusion imaging agent with rapid liver clearance: comparison with 99mTc-sestamibi and 99mTc-tetrofosmin in rats
    Kengo Hatada
    Experimental Cardiology Laboratory, Cardiovascular Division, Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia, USA
    J Nucl Med 45:2095-101. 2004
    ..We sought to compare the myocardial uptake and clearance kinetics and organ biodistribution of (99m)Tc-N-DBODC5 with (99m)Tc-sestamibi and (99m)Tc-tetrofosmin...
  21. pmc Human PON1, a biomarker of risk of disease and exposure
    C E Furlong
    University of Washington, Department of Medicine Div of Medical Genetics, Seattle, WA, United States
    Chem Biol Interact 187:355-61. 2010
    ..Immunolocalization studies of PONs 1, 2 and 3 in nearly all mouse tissues suggest that the functions of PONs 1 and 3 extend beyond the plasma and the HDL particle...
  22. ncbi Design and synthesis of active site inhibitors of the human farnesyl pyrophosphate synthase: apoptosis and inhibition of ERK phosphorylation in multiple myeloma cells
    Yih Shyan Lin
    Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC, Canada H3A 0B8
    J Med Chem 55:3201-15. 2012
    ..An analogue of this series was used to demonstrate inhibition of the intended biological target, resulting in apoptosis and down-regulation of ERK phosphorylation in human MM cell lines...
  23. pmc The mitochondria-targeted antioxidant mitoquinone protects against cold storage injury of renal tubular cells and rat kidneys
    Tanecia Mitchell
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    J Pharmacol Exp Ther 336:682-92. 2011
    ..These findings implicate that MitoQ could potentially be of therapeutic use for reducing organ preservation damage and kidney discardment and/or possibly improving renal function after transplantation...
  24. ncbi Non-invasive in vivo imaging of vessel calibre in orthotopic prostate tumour xenografts
    Simon Walker-Samuel
    Cancer Research UK and EPSRC Cancer Imaging Centre, The Institute of Cancer Research and Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom
    Int J Cancer 130:1284-93. 2012
    ....
  25. pmc Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy
    Partha Mukhopadhyay
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Free Radic Biol Med 52:497-506. 2012
    ..Because similar compounds seem to be safe in humans, mitochondrially targeted antioxidants may represent a novel therapeutic approach against cisplatin nephrotoxicity...
  26. ncbi Bevacizumab plus fotemustine as first-line treatment in metastatic melanoma patients: clinical activity and modulation of angiogenesis and lymphangiogenesis factors
    Michele Del Vecchio
    Unit of Medical Oncology 2, Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Clin Cancer Res 16:5862-72. 2010
    ..To assess the clinical and biological activity of the association of bevacizumab and fotemustine as first-line treatment in advanced melanoma patients...
  27. ncbi A mass spectrometry-based method to measure dialkylphosphate degradation products of organophosphorous insecticides in dust and orange juice
    Gayanga Weerasekera
    National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Mailstop F 17, Atlanta, Georgia, USA
    J Environ Monit 11:1345-51. 2009
    ..Evaluation of the conversion of intact pesticides in the samples to DAPs will help us to better understand the contribution of preformed DAPs to urinary DAP concentrations...
  28. ncbi Pesticides and their metabolites in the homes and urine of farmworker children living in the Salinas Valley, CA
    Asa Bradman
    Center for Children s Environmental Health Research, School of Public Health, University of California, Berkeley, CA 94720 7380, USA
    J Expo Sci Environ Epidemiol 17:331-49. 2007
    ..The child activity timeline, a novel, low-literacy instrument based on pictures, was successfully used by our participants. Future uses of these data include the development of pesticide exposure models and risk assessment...
  29. pmc Tagetitoxin inhibits RNA polymerase through trapping of the trigger loop
    Irina Artsimovitch
    Department of Microbiology and The Center for RNA Biology, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 286:40395-400. 2011
    ..Our studies highlight the role of TL as a target through which accessory proteins and antibiotics can alter the elongation complex dynamics...
  30. ncbi Mitochondria superoxide dismutase mimetic inhibits peroxide-induced oxidative damage and apoptosis: role of mitochondrial superoxide
    Anuradha Dhanasekaran
    Department of Biophysics and Free Radical Research Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Free Radic Biol Med 39:567-83. 2005
    ..We conclude that selective uptake of Mito-CP into the mitochondria is responsible for inhibiting peroxide-mediated Tf-Fe uptake and apoptosis and restoration of the proteasomal function...
  31. pmc Carboxylesterases 1 and 2 hydrolyze phospho-nonsteroidal anti-inflammatory drugs: relevance to their pharmacological activity
    Chi C Wong
    Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, New York 11794 8173, USA
    J Pharmacol Exp Ther 340:422-32. 2012
    ..037). Our results show that carboxylesterase mediates that metabolic inactivation of phospho-NSAIDs, and the inhibition of carboxylesterases improves the efficacy of phospho-NSAIDs in vitro and in vivo...
  32. pmc Organophosphorus pesticide exposure of urban and suburban preschool children with organic and conventional diets
    Cynthia L Curl
    Department of Environmental Health, School of Public Health and Community Medicine, University of Washington, Seattle, Washington, USA
    Environ Health Perspect 111:377-82. 2003
    ..Consumption of organic produce appears to provide a relatively simple way for parents to reduce their children's exposure to OP pesticides...
  33. pmc Structural basis for transcription inhibition by tagetitoxin
    Dmitry G Vassylyev
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, School of Medicine, Birmingham, Alabama 35294, USA
    Nat Struct Mol Biol 12:1086-93. 2005
    ..Remodeling of the active site by metal ions could be a common theme in the regulation of catalysis by nucleic acid enzymes...
  34. pmc Intercalating nucleic acids containing insertions of 1-O-(1-pyrenylmethyl)glycerol: stabilisation of dsDNA and discrimination of DNA over RNA
    Ulf B Christensen
    Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, DK 5230 Odense M, Denmark
    Nucleic Acids Res 30:4918-25. 2002
    ..Fluorescence measurements show a stronger interaction of the pyrene moiety with DNA than with RNA, indicating intercalation as the stabilising factor in DNA/INA duplexes...
  35. ncbi Animal and human studies with the mitochondria-targeted antioxidant MitoQ
    Robin A J Smith
    Department of Chemistry, University of Otago, Dunedin, New Zealand
    Ann N Y Acad Sci 1201:96-103. 2010
    ..MitoQ has now been used in a range of in vivo studies in rats and mice and in two phase II human trials. Here, we review what has been learned from these animal and human studies with MitoQ...
  36. pmc Detection of organophosphate flame retardants in furniture foam and U.S. house dust
    Heather M Stapleton
    Nicholas School of the Environment, Duke University, Durham, North Carolina, USA
    Environ Sci Technol 43:7490-5. 2009
    ..The high prevalence of these chemicals in foam and the high concentrations measured in dust (as high as 1.8 mg/g) warrant further studies to evaluate potential health effects from dust exposure, particularly for children...
  37. ncbi Preparation of ethylene gas and comparison of ethylene responses induced by ethylene, ACC, and ethephon
    Wei Zhang
    National Key Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
    Plant Physiol Biochem 48:45-53. 2010
    ..For laboratories that do not have an ethylene tank, ethylene gas can be easily prepared by a chemical approach without further purification...
  38. ncbi Acetal levulinyl ester (ALE) groups for 2'-hydroxyl protection of ribonucleosides in the synthesis of oligoribonucleotides on glass and microarrays
    Jeremy G Lackey
    Department of Chemistry, McGill University, Montreal, Quebec, Canada H3A 2K6
    J Am Chem Soc 131:8496-502. 2009
    ..The chemistry and methods described here pave the way to the fabrication of microarrays of immobilized RNA probes for analyzing molecular interactions of biological interest...
  39. pmc Urinary metabolite concentrations of organophosphorous pesticides, bisphenol A, and phthalates among pregnant women in Rotterdam, the Netherlands: the Generation R study
    Xibiao Ye
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, MD A3 05, PO Box 12233, Research Triangle Park, NC 27709, USA
    Environ Res 108:260-7. 2008
    ..The data indicate that the Generation R study population provides a wide distribution of selected environmental exposures. Reasons for the relatively high levels and possible health effects need investigation...
  40. ncbi The presence of dialkylphosphates in fresh fruit juices: implication for organophosphorus pesticide exposure and risk assessments
    C Lu
    Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    J Toxicol Environ Health A 68:209-27. 2005
    ..In conclusion, urinary DAPs have many limitations when being used as biomarkers for OP pesticides in exposure and risk assessment, and caution should be exercised when interpreting DAPs results...
  41. ncbi Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
    H Jomaa
    Institute of Biochemistry, Academic Hospital Centre, Justus Liebig University, Friedrichstrasse 24, D 35392 Giessen, Germany
    Science 285:1573-6. 1999
    ..Both drugs suppressed the in vitro growth of multidrug-resistant P. falciparum strains. After therapy with these drugs, mice infected with the rodent malaria parasite P. vinckei were cured...
  42. ncbi Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast
    Stuart A Ralph
    Institut Pasteur, Biology of Host Parasite Interactions, 25 rue du Docteur Roux, 75724, Paris, Cedex 15, France
    Nat Rev Microbiol 2:203-16. 2004
  43. pmc Mitochondrial-targeted nitroxides disrupt mitochondrial architecture and inhibit expression of peroxiredoxin 3 and FOXM1 in malignant mesothelioma cells
    Brian Cunniff
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Cell Physiol 228:835-45. 2013
    ....
  44. ncbi Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living Drosophila
    Helena M Cocheme
    Medical Research Council, Mitochondrial Biology Unit, Cambridge, UK
    Nat Protoc 7:946-58. 2012
    ..This method facilitates the investigation of mitochondrial H(2)O(2) in fly models of pathology and metabolic alteration, and it can also be extended to assess mitochondrial H(2)O(2) production in mouse and cell culture studies...
  45. pmc The novel phospho-non-steroidal anti-inflammatory drugs, OXT-328, MDC-22 and MDC-917, inhibit adjuvant-induced arthritis in rats
    L Huang
    Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY, USA
    Br J Pharmacol 162:1521-33. 2011
    ..We evaluated the anti-inflammatory efficacy and safety of three novel modified NSAIDs, phospho-aspirin, phospho-ibuprofen and phospho-sulindac...
  46. ncbi Review on the use of enzymes for the detection of organochlorine, organophosphate and carbamate pesticides in the environment
    J Susan Van Dyk
    Department of Biochemistry, Microbiology and Biotechnology, Rhodes University, Grahamstown 6140, South Africa
    Chemosphere 82:291-307. 2011
    ..These methods can serve as a tool for screening large samples which can be followed up with the more traditional chromatographic methods of analysis...
  47. pmc The metabolism and pharmacokinetics of phospho-sulindac (OXT-328) and the effect of difluoromethylornithine
    G Xie
    Department of Medicine, Stony Brook University, Stony Brook, NY, USA
    Br J Pharmacol 165:2152-66. 2012
    ..Phospho-sulindac (PS; OXT-328) prevents colon cancer in mice, especially when combined with difluoromethylornithine (DFMO). Here, we explored its metabolism and pharmacokinetics...
  48. ncbi Rapid uptake of lipophilic triphenylphosphonium cations by mitochondria in vivo following intravenous injection: implications for mitochondria-specific therapies and probes
    Carolyn M Porteous
    Department of Chemistry, University of Otago, Dunedin 9054, New Zealand
    Biochim Biophys Acta 1800:1009-17. 2010
    ..One approach to this is to deliver antioxidants, probes and pharmacophores to mitochondria by conjugation to the lipophilic triphenylphosphonium (TPP) cation that is taken up selectively by mitochondria driven by the membrane potential...
  49. ncbi Interaction of the mitochondria-targeted antioxidant MitoQ with phospholipid bilayers and ubiquinone oxidoreductases
    Andrew M James
    Medical Research Council Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 2XY, United Kingdom
    J Biol Chem 282:14708-18. 2007
    ..These findings will facilitate the rational design of future mitochondria-targeted molecules...
  50. pmc Penetrating cation/fatty acid anion pair as a mitochondria-targeted protonophore
    Fedor F Severin
    Belozersky Institute of Physico Chemical Biology and Institute of Mitoengineering, Moscow State University, Vorobyevy Gory 1, Moscow 119991, Russia
    Proc Natl Acad Sci U S A 107:663-8. 2010
    ..Hydrophobic penetrating cations might be promising to treat obesity, senescence, and some kinds of cancer that require mitochondrial hyperpolarization...
  51. pmc In vivo manipulation of Vgamma9Vdelta2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients
    S Meraviglia
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Palermo, Italy
    Clin Exp Immunol 161:290-7. 2010
    ....
  52. pmc Mitochondria-targeted ubiquinone (MitoQ) decreases ethanol-dependent micro and macro hepatosteatosis
    Balu K Chacko
    Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Hepatology 54:153-63. 2011
    ..Interestingly, MitoQ completely blocked the increase in HIF1α in all ethanol-fed groups, which has previously been demonstrated in cell culture models and shown to be essential in ethanol-dependent hepatosteatosis...
  53. pmc Doxorubicin inactivates myocardial cytochrome c oxidase in rats: cardioprotection by Mito-Q
    Karunakaran Chandran
    Department of Biophysics and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Biophys J 96:1388-98. 2009
    ..Mito-Q restored CcO subunit II and Va expressions in DOX-treated rats. These results suggest a novel cardioprotection mechanism by Mito-Q during DOX-induced cardiomyopathy involving CcO...
  54. pmc Neuroprotection by a mitochondria-targeted drug in a Parkinson's disease model
    Anamitra Ghosh
    Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA
    Free Radic Biol Med 49:1674-84. 2010
    ..Collectively, these results indicate that mitochondrial targeting of antioxidants is a promising neuroprotective strategy in this preclinical mouse model of PD...
  55. pmc Phospho-sulindac (OXT-328) combined with difluoromethylornithine prevents colon cancer in mice
    Gerardo G MacKenzie
    Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA
    Cancer Prev Res (Phila) 4:1052-60. 2011
    ..P-S/DFMO has an intricate mechanism of action extending beyond polyamines and including the thioredoxin system, an emerging regulator of chemoprevention. P-S/DFMO merits further evaluation...
  56. pmc House dust concentrations of organophosphate flame retardants in relation to hormone levels and semen quality parameters
    John D Meeker
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, USA
    Environ Health Perspect 118:318-23. 2010
    ..Although widespread human exposure to OP flame retardants is likely, there is a lack of human and animal data on potential health effects...
  57. pmc Phospho-sulindac (OXT-328), a novel sulindac derivative, is safe and effective in colon cancer prevention in mice
    Gerardo G MacKenzie
    Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, New York 11794 8173, USA
    Gastroenterology 139:1320-32. 2010
    ..However, chronic administration of NSAIDs is associated with significant side effects, mainly of the gastrointestinal tract. Given these limitations, we synthesized phospho-sulindac (P-S; OXT-328), a novel sulindac derivative...
  58. ncbi Characterization of membrane potential-dependent uptake of the novel PET tracer 18F-fluorobenzyl triphenylphosphonium cation
    Igal Madar
    Division of Nuclear Medicine, The Russell H Morgan Department of Radiology, The Johns Hopkins Medical Institutions, 601 N Caroline Street, Baltimore, MD 21287, USA
    Eur J Nucl Med Mol Imaging 34:2057-65. 2007
    ....
  59. pmc A retrospective pooled analysis of response patterns and risk factors in recurrent malignant glioma patients receiving a nitrosourea-based chemotherapy
    Alessandro Paccapelo
    Department of Medical Oncology, Azienda Ospedaliero Universitaria, Ospedali Riuniti Umberto I GM Lancisi and G Salesi, Ancona, Italy
    J Transl Med 10:90. 2012
    ..We investigated whether FTM could have a different response pattern in respect to time to adjuvant temozolomide failure, or whether specific independent risk factors could be responsible for the wide range of response rates observed...
  60. pmc Urinary concentrations of dialkylphosphate metabolites of organophosphorus pesticides: National Health and Nutrition Examination Survey 1999-2004
    Dana Boyd Barr
    Emory University, Rollins School of Public Health, Atlanta, GA 30322, USA
    Int J Environ Res Public Health 8:3063-98. 2011
    ..However, according to DAP urinary metabolite data, exposures to OP pesticides have declined during the last six years at both the median and 95th percentile levels...
  61. ncbi Is antioxidant potential of the mitochondrial targeted ubiquinone derivative MitoQ conserved in cells lacking mtDNA?
    Chao Lu
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Republic of Singapore
    Antioxid Redox Signal 10:651-60. 2008
    ..Our results elucidate the antioxidant mechanism of MitoQ and suggest that it may be a useful therapeutic for disorders associated with a dysfunctional ETC and increased ROS production...
  62. ncbi Improved outcome prediction by SPECT myocardial perfusion imaging after CT attenuation correction
    Aju P Pazhenkottil
    Cardiac Imaging, University Hospital Zurich, Zurich, Switzerland
    J Nucl Med 52:196-200. 2011
    ..The aim of this study was to determine the impact of attenuation correction with CT (CT-AC) on the prognostic value of SPECT myocardial perfusion imaging (SPECT MPI)...
  63. ncbi Influence of 99mTc-tetrofosmin SPECT myocardial perfusion imaging on the prediction of future adverse cardiac events
    Diwakar Jain
    Drexel University College of Medicine, Philadelphia, PA, USA
    J Nucl Cardiol 16:540-8. 2009
    ..The impact of myocardial perfusion imaging (MPI) on prediction of risk for future cardiac events was examined by comparing predictions based on clinical information alone and in combination with MPI findings...
  64. ncbi Susceptibility contrast magnetic resonance imaging determination of fractional tumor blood volume: a noninvasive imaging biomarker of response to the vascular disrupting agent ZD6126
    Simon P Robinson
    Department of Basic Medical Sciences, St George s, University of London, London, United Kingdom
    Int J Radiat Oncol Biol Phys 69:872-9. 2007
    ..To assess tumor fractional blood volume (xi), determined in vivo by susceptibility contrast magnetic resonance imaging (MRI) as a noninvasive imaging biomarker of tumor response to the vascular disrupting agent ZD6126...
  65. ncbi Effects of NAAG peptidase inhibitor 2-PMPA in model chronic pain - relation to brain concentration
    Jens Nagel
    Preclinical R and D, Merz Pharmaceuticals GmbH, Eckenheimer Landstrasse 100, 60318 Frankfurt am Main, Germany
    Neuropharmacology 51:1163-71. 2006
    ..It appears therefore that the observed behavioural effects of 2-PMPA may not be mediated by NAAG nor, in turn, by mGluR3 receptors...
  66. pmc Synthesis of 2'-O-methyl-RNAs incorporating a 3-deazaguanine, and UV melting and computational studies on its hybridization properties
    Kohji Seio
    Frontier Collaborative Research Center, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama, Japan
    Nucleic Acids Res 34:4324-34. 2006
    ..Computational studies based on ab initio calculations suggest that the weaker hydrogen bonding ability and larger dipole moment of c3G can be the origin of the lower T(m)...
  67. pmc Correlation of MRI biomarkers with tumor necrosis in Hras5 tumor xenograft in athymic rats
    Daniel P Bradley
    Discovery Enabling Capabilities and Sciences, AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK
    Neoplasia 9:382-91. 2007
    ..These data on Hras5 tumors suggest that the quantification of hypoperfused voxels might provide a useful biomarker of tumor necrosis...
  68. pmc Is the PentaBDE replacement, tris (1,3-dichloro-2-propyl) phosphate (TDCPP), a developmental neurotoxicant? Studies in PC12 cells
    Laura V Dishaw
    Nicholas School of the Environment, Duke University, Durham, NC 27708, USA
    Toxicol Appl Pharmacol 256:281-9. 2011
    ..Additionally, these data suggest that OPFRs may affect neurodevelopment with similar or greater potency compared to known and suspected neurotoxicants...
  69. ncbi Phosphorus flame retardants: properties, production, environmental occurrence, toxicity and analysis
    Ike van der Veen
    VU University, Institute for Environmental Studies IVM, De Boelelaan 1087, 1081 HV, Amsterdam, The Netherlands
    Chemosphere 88:1119-53. 2012
    ..GC-MS offers a higher selectivity than GC-NPD and the possibility of using isotopically labeled compounds for quantification...
  70. pmc Treatment of recurrent malignant gliomas with fotemustine monotherapy: impact of dose and correlation with MGMT promoter methylation
    Alessandra Fabi
    Division of Medical Oncology, Regina Elena Cancer Institute, Rome, Italy
    BMC Cancer 9:101. 2009
    ..Also, the impact of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status on fotemustine activity has never been explored in the clinical setting...
  71. ncbi Functionally relevant coronary artery disease: comparison of 64-section CT angiography with myocardial perfusion SPECT
    Oliver Gaemperli
    Cardiovascular Center, University Hospital Zurich, Ramistrasse 100, NUK C 32, CH 8091 Zurich, Switzerland
    Radiology 248:414-23. 2008
    ....
  72. ncbi Microbial degradation of organophosphorus compounds
    Brajesh K Singh
    Environmental Sciences, Macaulay Institute, Craigiebuckler, Aberdeen, UK
    FEMS Microbiol Rev 30:428-71. 2006
    Synthetic organophosphorus compounds are used as pesticides, plasticizers, air fuel ingredients and chemical warfare agents...
  73. ncbi NO-1886 upregulates ATP binding cassette transporter A1 and inhibits diet-induced atherosclerosis in Chinese Bama minipigs
    Chi Zhang
    Institute of Cardiovascular Research, Nanhua University Medical School, Hengyang, Hunan 421001, China
    J Lipid Res 47:2055-63. 2006
    ..These results demonstrate that the mechanism of atherosclerosis inhibition for NO-1886 is associated with its effect on ABCA1...
  74. ncbi Analysis of inhibition, reactivation and aging kinetics of highly toxic organophosphorus compounds with human and pig acetylcholinesterase
    N Aurbek
    Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937 Munich, Germany
    Toxicology 224:91-9. 2006
    b>Organophosphorus compounds (OP) are in wide spread use as pesticides and highly toxic OP may be used as chemical warfare agents (nerve agents)...
  75. pmc Postillumination isoprene emission: in vivo measurements of dimethylallyldiphosphate pool size and isoprene synthase kinetics in aspen leaves
    Bahtijor Rasulov
    Department of Plant Physiology, University of Tartu, 51010 Tartu, Estonia
    Plant Physiol 149:1609-18. 2009
    ....
  76. ncbi Functional genomic of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism
    Lucio G Costa
    Department of Environmental Health, University of Washington, Seattle, Washington 98195, USA
    Annu Rev Med 54:371-92. 2003
    ..A more recent area of investigation, the role of PON1 in drug metabolism, is also discussed. We emphasize the importance of considering both PON1 isoforms and PON1 levels in disease/sensitivity association studies...
  77. pmc 5-Fluoro pyrimidines: labels to probe DNA and RNA secondary structures by 1D 19F NMR spectroscopy
    Barbara Puffer
    Institute of Organic Chemistry, Center for Molecular Biosciences CMBI, University of Innsbruck, 6020 Innsbruck, Austria, Laboratory of Organic Chemistry, ETH Zurich, 8093 Zurich, Switzerland and Max Perutz Laboratories, Vienna Biocenter, University of Vienna, 1030 Vienna, Austria
    Nucleic Acids Res 37:7728-40. 2009
    ..Furthermore, we developed a facile synthetic route towards 5-fluoro cytidine phosphoramidites that enables their convenient site-specific incorporation into oligonucleotides by solid-phase synthesis...
  78. ncbi Therapy of metastatic bone pain
    A N Serafini
    Division of Nuclear Medicine, Department of Radiology, University of Miami/Sylvester Comprehensive Cancer Center/Jackson Memorial Medical Center, Miami, Florida 33101, USA
    J Nucl Med 42:895-906. 2001
    ....
  79. ncbi Specific modification of mitochondrial protein thiols in response to oxidative stress: a proteomics approach
    Tsu Kung Lin
    Department of Biochemistry, University of Otago, Box 56, Dunedin, New Zealand
    J Biol Chem 277:17048-56. 2002
    ..In addition the methodology has the potential to identify novel redox-dependent modulation of mitochondrial proteins...
  80. ncbi Inhibitory effect of efonidipine on aldosterone synthesis and secretion in human adrenocarcinoma (H295R) cells
    Keiichi Imagawa
    First Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    J Cardiovasc Pharmacol 47:133-8. 2006
    ....
  81. ncbi The nematode Caenorhabditis elegans as a model of organophosphate-induced mammalian neurotoxicity
    Russell D Cole
    Department of Environmental Health Science, The University of Georgia, Athens, GA 30602 2102, USA
    Toxicol Appl Pharmacol 194:248-56. 2004
    ..These results have positive implications for the use of C. elegans as a mammalian neurological model and support the use of C. elegans in early rounds of chemical toxicity screening...
  82. pmc MitoQ administration prevents endotoxin-induced cardiac dysfunction
    G S Supinski
    Division of Pulmonary, Critical Care, and Sleep Medicine, University of Kentucky, Lexington, Kentucky 40536 0284, USA
    Am J Physiol Regul Integr Comp Physiol 297:R1095-102. 2009
    ..01). These data demonstrate that MitoQ is a potent inhibitor of endotoxin-induced mitochondrial and cardiac abnormalities. We speculate that this agent may prove a novel therapy for sepsis-induced cardiac dysfunction...
  83. ncbi Comparison of organophosphorus pesticide metabolite levels in single and multiple daily urine samples collected from preschool children in Washington State
    John C Kissel
    Department of Environmental and Occupational Health Sciences, School of Public Health and Community Medicine, University of Washington, Seattle, Washington 98195, USA
    J Expo Anal Environ Epidemiol 15:164-71. 2005
    ..The results of this analysis suggest that if spot sampling is to be conducted as part of a biological monitoring study, first morning void samples should be preferentially collected...
  84. pmc The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer's disease
    Meagan J McManus
    Department of Pharmaceutical and Biomedical Sciences, The University of Georgia College of Pharmacy, Athens, Georgia 30602, USA
    J Neurosci 31:15703-15. 2011
    ....
  85. pmc The synthesis of oligoribonucleotides containing N6-alkyladenosines and 2-methylthio-N6-alkyladenosines via post-synthetic modification of precursor oligomers
    Elzbieta Kierzek
    Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12 14, 61 704 Poznan, Poland
    Nucleic Acids Res 31:4461-71. 2003
    ....
  86. pmc Association of in utero organophosphate pesticide exposure and fetal growth and length of gestation in an agricultural population
    Brenda Eskenazi
    Center for Children s Environmental Health Research, School of Public Health, University of California Berkeley, 94720 7380, USA
    Environ Health Perspect 112:1116-24. 2004
    ..However, despite these observed associations, the rate of preterm delivery in this population (6.4%) was lower than in a U.S. reference population...
  87. ncbi Neurotoxic disorders of organophosphorus compounds and their managements
    Mahdi Balali-Mood
    Medical Toxicology Center, Imam Reza Hospital, Mashhad University of Medical Sciences, Iran
    Arch Iran Med 11:65-89. 2008
    b>Organophosphorus compounds have been used as pesticides and as chemical warfare nerve agents...
  88. ncbi Low-level exposures to organophosphorus esters and peripheral nerve function
    Marcello Lotti
    Universita degli Studi di Padova, Dipartimento di Medicina Ambientale e Sanità Pubblica, Azienda Ospedaliera, Via Giustiniani 2, 35148 Padua, Italy
    Muscle Nerve 25:492-504. 2002
    ..It is concluded that there is no evidence of peripheral nerve dysfunction caused by low-level prolonged exposures to organophosphate insecticides or nerve agents...
  89. pmc Validation of PON1 enzyme activity assays for longitudinal studies
    Karen Huen
    Center for Children s Environmental Health, School of Public Health, University of California, Berkeley, CA 94720 7360, United States
    Clin Chim Acta 402:67-74. 2009
    ..Length of sample storage, temperature and other factors may influence variability of PON1 measurements, especially in longitudinal studies...
  90. pmc Predicting outcome using butyrylcholinesterase activity in organophosphorus pesticide self-poisoning
    M Eddleston
    Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, and Clinical Pharmacology Unit, University of Edinburgh, UK
    QJM 101:467-74. 2008
    ..Previous studies have been confounded by the inclusion of multiple insecticides with differing inhibitory kinetics...
  91. ncbi Detoxification of organophosphate nerve agents by bacterial phosphotriesterase
    Eman Ghanem
    Department of Chemistry, Texas A and M University, P O Box 30012, College Station, TX 77843 3012, USA
    Toxicol Appl Pharmacol 207:459-70. 2005
    ..In this review, the catalytic properties and potential applications of this remarkable enzyme are discussed...
  92. pmc Correspondence: preformed biomarkers in produce inflate human organophosphate exposure assessments
    Robert I Krieger
    Environ Health Perspect 111:A688-9; author reply A89-91. 2003
  93. pmc Role of CD8(+) lymphocytes in control of simian immunodeficiency virus infection and resistance to rechallenge after transient early antiretroviral treatment
    J D Lifson
    Retroviral Pathogenesis Laboratory, AIDS Vaccine Program, SAIC Frederick, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    J Virol 75:10187-99. 2001
    ..The results help establish the underlying feasibility of efforts to develop vaccines for the prevention of AIDS, although the exact nature of the protective host responses involved remains to be elucidated...
  94. ncbi Acetylcholinesterase inhibition: does it explain the toxicity of organophosphorus compounds?
    Donald M Maxwell
    US Army Medical Research Institute of Chemical Defense, 3100 Ricketts Point Road, Aberdeen Proving Ground, MD 21010 5400, USA
    Arch Toxicol 80:756-60. 2006
    ....
  95. ncbi Rapid multiresidue determination of organochlorine and organophosphorus compounds in human serum by solid-phase extraction and gas chromatography coupled to tandem mass spectrometry
    E Pitarch
    Analytical Chemistry, Experimental Sciences Dept, University Jaume I, PO Box 8029 AP, 12080 Castellon, Spain
    Anal Bioanal Chem 376:189-97. 2003
    ..The method was applied to several serum samples obtained from farmers devoted to citrus crop production. Chlorpyrifos, HCB, p, p'-DDE and the higher chlorinated PCBs (153, 138 and 180) were the most frequently detected compounds...
  96. ncbi Administration of 9-[2-(phosphonomethoxy)propyl]adenine (PMPA) for prevention of perinatal simian immunodeficiency virus infection in rhesus macaques
    K K Van Rompay
    California Regional Primate Research Center, University of California, Davis 95616, USA
    AIDS Res Hum Retroviruses 14:761-73. 1998
    ..Our data demonstrate that PMPA treatment can reduce perinatal SIV infection and suggest that similar strategies may also be effective against HIV...
  97. ncbi Focus on Fotemustine
    A De Rossi
    Department of Neuroscience, University of Rome Tor Vergata, Italy
    J Exp Clin Cancer Res 25:461-8. 2006
    ..Therefore, it is reasonable to assume that this agent could be a good candidate to play a potential role in haematological malignancies...
  98. pmc Association of organophosphate pesticide exposure and paraoxonase with birth outcome in Mexican-American women
    Kim G Harley
    Center for Environmental Research and Children s Health, School of Public Health, University of California, Berkeley, California, United States of America
    PLoS ONE 6:e23923. 2011
    ..We explored whether paraoxonase (PON1), a key enzyme involved in detoxification of OPs, could be an effect modifier in this association...
  99. ncbi Effects of long-term organophosphate exposures on neurological symptoms, vibration sense and tremor among South African farm workers
    L London
    Department of Community Health, University of Cape Town, Observatory, South Africa
    Scand J Work Environ Health 24:18-29. 1998
    ..This study assessed the relationship between long-term exposure to organophosphate insecticides and neurological symptoms, vibration sense, and motor tremor after control for the effect of past poisoning and acute exposure...
  100. ncbi Biosynthesis of isoprenoids via mevalonate in Archaea: the lost pathway
    A Smit
    Institute for Systems Biology, Seattle, Washington 98195, USA
    Genome Res 10:1468-84. 2000
    ..Combining these approaches resulted in the generation of a short list of 13 candidate genes for the three missing functions in archaea, whose participation in isoprenoid biosynthesis is amenable to biochemical and genetic investigation...
  101. ncbi Behavioral effects of occupational exposure to organophosphorous pesticides in female greenhouse planting workers
    B Bazylewicz-Walczak
    Department of Work Psychology, The Nofer Institute of Occupational Medicine, Lodz, Poland
    Neurotoxicology 20:819-26. 1999
    ..In addition, increased tension, greater depression and fatigue, more frequent symptoms of CNS disturbances were observed in the exposed women compared to the controls...

Research Grants65

  1. Age and sex effects on nerve agent damage to the brain and antidotal therapies
    Edson X Albuquerque; Fiscal Year: 2010
    The nerve agents soman, sarin and VX are organophosphorus compounds (OPs) chemically related to, but far more toxic than OP insecticides...
  2. PEG-MODIFIED ENZYMES FOR IN-VIVO DECON OF OP TOXINS
    KEITH LEJEUNE; Fiscal Year: 2003
    ..Several known enzymes exhibit hydrolytic activity on target organophosphorus compounds including nerve agent chemical weapons such as sarin and soman as well as many commercially available ..
  3. PEG-MODIFIED ENZYMES FOR IN-VIVO DECON OF OP TOXINS
    KEITH LEJEUNE; Fiscal Year: 2001
    ..Several known enzymes exhibit hydrolytic activity on target organophosphorus compounds including nerve agent, chemical weapons such as sarin and soman as well as many commercially available ..
  4. ANTAGONISM OF ORGANOPHOSPHOROUS INTOXICATIONS
    James Way; Fiscal Year: 1992
    The use of organophosphorus compounds as a pesticide is widespread. This affects not only agricultural workers, but the entire population, e.g...
  5. OCCUPATIONAL NEUROPATHIES DUE TO INDUSTRIAL CHEMICALS
    MOHAMED ABOU DONIA; Fiscal Year: 1992
    ..In the final section we continue work on the joint mechanism of action of organophosphorus compounds and hexacarbon compounds...
  6. STEREOSPECIFICITY IN ANTITUMOR ACTIVITY
    KENNETH DEBRUIN; Fiscal Year: 1980
    The two antitumor agents, Cyclophsophamide and Isophosphamide, are chiral organophosphorus compounds which require microsomal activation in vivo to their cytotoxic forms...
  7. H-Phosphinic Acids in the Preparation of Active Organophosphorus Compounds
    Jean Luc Montchamp; Fiscal Year: 2008
    ..Thus, beyond the scope of this proposal, some of the chemistry detailed therein should make a significant contribution to the realm of phosphorus-based medicinal chemistry in general. ..
  8. Neuropharmacology of GHB discrimination
    Wouter Koek; Fiscal Year: 2010
    ..Increased knowledge about the activation and modulation of GABAB systems will help to develop effective approaches to treating sleep-, drug abuse-, and other CNS disorders. ..
  9. Discriminative Stimulus Effects of Alcohol in Mice
    Wouter Koek; Fiscal Year: 2007
    ..This future research will increase our understanding of risk factors for alcoholism and drug abuse and will help the development of effective approaches to prevention and treatment. [unreadable] [unreadable] [unreadable]..
  10. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 2003
    ....
  11. Fetal & Adolescent Nicotine Effects on CNS 5HT Systems
    Theodore Slotkin; Fiscal Year: 2003
    ..abstract_text> ..
  12. MECHANISMS OF CHLORPYRIFOS DEVELOPMENTAL NEUROTOXICITY
    Theodore Slotkin; Fiscal Year: 2004
    ..Molecular mechanisms of developmental neurotoxicity can be determined and linked to eventual alterations in behavioral performance. ..
  13. Community-Based Participatory Approach to Farmworker Housing, Exposures & Health
    Thomas A Arcury; Fiscal Year: 2010
    ....
  14. Differences in CAM Use Among Minority Older Adults
    Thomas Arcury; Fiscal Year: 2005
    ..abstract_text> ..
  15. Reducing pesticide exposures to farmworker children.
    Brenda Eskenazi; Fiscal Year: 2005
    ....
  16. Ethnic Variation in CAM Use and Health Self Management among Rural Older Adults
    Thomas Arcury; Fiscal Year: 2009
    ....
  17. African American Men Prostate & Colorectal Cancer Belief
    Thomas Arcury; Fiscal Year: 2007
    ..A preliminary framework of the intervention strategy for this R01 application will be developed and evaluated as part of this project. [unreadable] [unreadable]..
  18. Genetic damage in the sperm and blood of workers exposed to benzene
    Brenda Eskenazi; Fiscal Year: 2008
    ..Lastly, this study is one of the first to investigate the relative sensitivities of sperm and blood cells to chromosomal defects induced by benzene. [unreadable] [unreadable] [unreadable]..
  19. KINETICS OF DRUG MACROMOLECULE COMPLEX FORMATION
    Palmer Taylor; Fiscal Year: 2008
    ..abstract_text> ..
  20. PBDEs, DDT and Neurodevelopment in School-Aged Mexican-American Children
    Brenda Eskenazi; Fiscal Year: 2010
    ....
  21. Nicotinic Receptor Template-guided Drug Design
    Palmer Taylor; Fiscal Year: 2008
    ..The final stages of investigation will include studies in rodents to determine efficacy and toxicity. ..
  22. 2008 WESTERN ARGICULTURAL CONFERENCE
    Richard Fenske; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  23. Farmwoker Environmental Health Research Comparable Data
    Thomas Arcury; Fiscal Year: 2004
    ..The purpose of limiting the size of the conference is to facilitate active interaction, discussion and debate among leaders in the field. ..
  24. OPTICAL ASSESSMENT OF DERMAL EXPOSURE AND ABSORPTION
    Richard Fenske; Fiscal Year: 2002
    ....
  25. Nuclease-Resistant Aptamers for Anthrax Opsonization
    John Bruno; Fiscal Year: 2004
    ..Such shielded aptamers could even be used in inhalers to enhance alveolar macrophage phagocytosis. ..
  26. FACILITIES CONSTRUCTION CENTERALIZED PHARMCOGENOMICS
    Palmer Taylor; Fiscal Year: 2003
    ..The Centralized Animal Facility is critically needed to support this effort and allow economies of scale for animal research. ..
  27. Phase II Trial of Thalidomide in Primary Amyloidosis
    Angela Dispenzieri; Fiscal Year: 2002
    ..The ultimate goal of the proposed studies is to improve the prognosis of patient with this fatal disease. ..
  28. Nuclease-Resistant Aptamers to Botox and Anthrax Toxins
    John Bruno; Fiscal Year: 2004
    ..Such reagents could also be used in environmental biosensors or diagnostic test kits for detection of BOTOX and anthrax toxins in body fluids or environmental samples. ..
  29. Development of an Intranasal Rotavirus Subunit Vaccine
    ALEXANDER ANDRIANOV; Fiscal Year: 2002
    ..In Phase III SBIR studies, we will conduct safety, immunogencity and efficacy trials in humans and seek FDA approval. ..
  30. Casa A Campo: Pesticide Safety for Farmworkers' Families
    Thomas Arcury; Fiscal Year: 2004
    ....
  31. RADIATION AND DRUG EFFECTS ON TUMOR CELL SUBPOPULATIONS
    Dietmar Siemann; Fiscal Year: 2001
    ..Ultimately we hope that these approaches can be reliably developed to an extent where the use of human tumor biopsy material may lead to radiotherapy treatments more tailored to the individual patient. ..
  32. Endocrine Disruptors and Neurodevelopmental Outcomes
    Brenda Eskenazi; Fiscal Year: 2004
    ..This study will provide the first data on exposure and health effects of ED pesticides in a highly exposed population, complete the exposure profile of CHAMACOS children, and target interventions to reduce child exposures. ..
  33. MOP Receptor Effects on the Hippocampal CA1 Network
    ADAM MCQUISTON; Fiscal Year: 2008
    ..The results from these studies will provide important information regarding MOP receptor-induced changes in network activity and may possibly lead to the development of treatments for opioid addiction. ..
  34. Genetic evaluation of nitric oxide regulating genes in ischemic stroke
    Timothy Howard; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  35. Alcohol Sensitivity and PET Derived Measures of Opioid Activity
    Elise M Weerts; Fiscal Year: 2010
    ..The results of the proposed research will increase our understanding of to the relationship between individual variability in the opioid system and subjective sensitivity to alcohol. ..
  36. Non-Invasive System for Identifying Neural Behavior
    Carlo De Luca; Fiscal Year: 2009
    ..It will be useful to clinicians for assessing the degree of dysfunction in upper motoneuron diseases such as Cerebral Palsy, Parkinson's Disease, ALS, Stroke, and other disorders. ..
  37. Behavioral Pharmacology and GHB Physical Dependence
    Elise M Weerts; Fiscal Year: 2010
    ..Physical dependence in the context of self-injection of GHB, GBL and 1,4-BD will also be evaluated. These studies will provide critical information on the behavioral pharmacology and dependence-producing effects of GHB. ..
  38. Chemistry to Improve Human Genomic Array Analysis Architectures
    Steven A Benner; Fiscal Year: 2010
    ..This proposal seeks funds to benchmark the improvements in array performance generated by these new technologies, improve them by a cycle of test and redesign, and provide them to the genomics community. ..
  39. Molecular Regulation of Primary Dendritogenesis
    Pamela Lein; Fiscal Year: 2005
    ..abstract_text> ..
  40. Near Term Development of Reagents and Enzymes for Genome Sequencing
    Steven A Benner; Fiscal Year: 2010
    ..This proposal, from a laboratory with a track record of innovation in structures, reagents, and enzymes to manipulate nucleic acids, is focused on near term development of these to enable NHGRI cost-reduction sequencing goals. ..
  41. EVOLUTION OF THE RIBONUCLEASE SUPERFAMILY
    Steven Benner; Fiscal Year: 2001
    ....
  42. MAPK/PKR Modulation of Diaphragm Weakness
    Gerald S Supinski; Fiscal Year: 2010
    ..We will both characterize the effects of inflammation on DISC formation, localization, and autocatalytic activity and determine if these alterations can be blocked by inhibition of p38, JNK, and/or PKR signaling pathways. ..
  43. Artificial Genetic Systems
    Steven A Benner; Fiscal Year: 2010
    ..Multiplexed PCR is the rate limiting step in many genomics analyses. Our long term, highly ambitious goal is to develop a "synthetic biology", a chemical system capable of Darwinian evolution, based on AEGIS components. ..
  44. Molecular mechanisms of transcription elongation
    Dmitry Vassylyev; Fiscal Year: 2009
    ..the facile translocation upon nucleotide addition, the effects of systematic variation of the scaffold components and substitutions of the key RNA polymerase residues that are highlighted by the structure will be analyzed ..
  45. Cue-Reactivity and Alcohol Self-Dosing
    Elise Weerts; Fiscal Year: 2003
    ..This research will additionally provide important information on the behavioral processes underlying conditioned responses to drug-related cues in animals which may be relevant to cue-reactivity and drug-taking in humans. ..
  46. Exploration of ETS Effects on Child Behavior and Sleep
    Kimberly Yolton; Fiscal Year: 2005
    ..abstract_text> ..
  47. STRUCTURE/FUNCTION OF EPOXIDE HYDROLASE
    David Christianson; Fiscal Year: 2005
    ..abstract_text> ..
  48. Bioresponsive Microbicides for AIDS Prevention
    PATRICK KISER; Fiscal Year: 2005
    ..abstract_text> ..
  49. HARNESSING MOTONEURON ACTIVITY: FROM LAB TO CLINIC
    Carlo De Luca; Fiscal Year: 2004
    ..As well as testing specific hypotheses, these studies will be used to test and improve the evolving design of the new decomposition system. ..
  50. Neural Circulatory Control: Pregnancy & Ovarian Hormones
    CHERYL HEESCH; Fiscal Year: 2007
    ..abstract_text> ..
  51. Chemically Modified dNTPs as a General Approach for Improved Hot Start PCR
    ALEXANDRE LEBEDEV; Fiscal Year: 2007
    ..To further improve the accuracy of the PCR technique, we propose the investigation of a novel Hot Start PCR approach, in which the dNTP substrates are chemically modified. [unreadable] [unreadable] [unreadable]..
  52. MOLECULAR ANALYSIS OF NEURONAL T TYPE CA++ CHANNELS
    Edward Perez Reyes; Fiscal Year: 2007
    ..Lead compounds will be sent to the NIH Anticonvulsant Drug Development Program for in vivo testing. These studies will test the hypothesis that more potent channel blockers are better antiepileptics and the importance of selectivity. ..
  53. Chemically Modified Primers for Improved Hot Start PCR
    ALEXANDRE LEBEDEV; Fiscal Year: 2007
    ..Herein we propose the further development of a novel "Hot Start" PCR strategy which may have potential utility in the amplification of low-copy-number DNA. [unreadable] [unreadable] [unreadable]..
  54. FREE RADICALS AND MUSCLE DYSFUNCTION IN HEART FAILURE
    GERALD SUPINSKI; Fiscal Year: 2005
    ..These data suggest that the proposed experiments should provide important information regarding the pathogenesis of heart failure-related skeletal muscle dysfunction. ..
  55. Phage Lysogeny and Inhibition of Biofilm Formation
    GEORGE O TOOLE; Fiscal Year: 2008
    ..Specific Aim III. Determine DMA sequence of phage DMS577 and the mechanism by which DMS577 interferes with biofilm formation. [unreadable] [unreadable] [unreadable] [unreadable]..
  56. Mechanisms of Biofilm Antibiotic Resistance in Staphylococcus
    GEORGE O TOOLE; Fiscal Year: 2004
    ....
  57. Tumor Suppressors in Lymphocytes
    Matthias Wabl; Fiscal Year: 2008
    ..Subsequently, a subset of them will be further characterized and the nature of their cooperation with other oncogenes (co-mutations) will be determined. ..
  58. Glutamate Vesicular Transport:Pharmacophore Development
    Charles Thompson; Fiscal Year: 2006
    ..Using N-term VGLUT antibodies, affinity tags, tethered- and cross-linking probes, VGLUT residues and structures proximal to VGLUT will be isolated and identified by mass spectrometry. ..
  59. New York State Angler Cohort Follow-up Study
    Matthew Bonner; Fiscal Year: 2009
    ..abstract_text> ..
  60. Caspase Mediated Diaphragmatic Dysfunction
    GERALD SUPINSKI; Fiscal Year: 2009
    ..These experiments will use both transgenic animal models and C2C12 cells to assess the effect of genetic and chemical inhibition of superoxide/nitric oxide on caspase responses. ..
  61. Radioimmunotherapy for Prostate Cancer
    Michael Morris; Fiscal Year: 2007
    ..The acquisition of these skills combined with the completion of the research plan will allow the candidate to pursue such research independently. ..
  62. Novel Ternary Ligand 99m Tc-Nitrido Complexes as Heart Imaging Agents
    Shuang Liu; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  63. Novel Cationic 99mTc Complexes for Heart Imaging
    Shuang Liu; Fiscal Year: 2006
    ..Successful development of new 99mTc perfusion imaging agents will have a profound impact on diagnostic evaluation, risk stratification, and therapeutic decision-making in patients with CAD. ..