organophosphorus compounds

Summary

Summary: Organic compounds that contain phosphorus as an integral part of the molecule.

Top Publications

  1. pmc Organophosphate pesticide exposure and attention in young Mexican-American children: the CHAMACOS study
    Amy R Marks
    Center for Children s Environmental Health Research, School of Public Health, University of California, Berkeley, Berkeley, California 94720, USA
    Environ Health Perspect 118:1768-74. 2010
  2. ncbi Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury
    Victoria J Adlam
    Department of Chemistry, University of Otago, Dunedin, New Zealand
    FASEB J 19:1088-95. 2005
  3. doi Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix
    Helena M Cocheme
    Medical Research Council Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK
    Cell Metab 13:340-50. 2011
  4. ncbi 99mTc-N-DBODC5, a new myocardial perfusion imaging agent with rapid liver clearance: comparison with 99mTc-sestamibi and 99mTc-tetrofosmin in rats
    Kengo Hatada
    Experimental Cardiology Laboratory, Cardiovascular Division, Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia, USA
    J Nucl Med 45:2095-101. 2004
  5. pmc The novel phospho-non-steroidal anti-inflammatory drugs, OXT-328, MDC-22 and MDC-917, inhibit adjuvant-induced arthritis in rats
    L Huang
    Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY, USA
    Br J Pharmacol 162:1521-33. 2011
  6. pmc Phospho-sulindac (OXT-328) combined with difluoromethylornithine prevents colon cancer in mice
    Gerardo G MacKenzie
    Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA
    Cancer Prev Res (Phila) 4:1052-60. 2011
  7. pmc Human PON1, a biomarker of risk of disease and exposure
    C E Furlong
    University of Washington, Department of Medicine Div of Medical Genetics, Seattle, WA, United States
    Chem Biol Interact 187:355-61. 2010
  8. doi Design and synthesis of active site inhibitors of the human farnesyl pyrophosphate synthase: apoptosis and inhibition of ERK phosphorylation in multiple myeloma cells
    Yih Shyan Lin
    Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC, Canada H3A 0B8
    J Med Chem 55:3201-15. 2012
  9. doi Neuroprotection by a mitochondria-targeted drug in a Parkinson's disease model
    Anamitra Ghosh
    Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA
    Free Radic Biol Med 49:1674-84. 2010
  10. pmc The mitochondria-targeted antioxidant mitoquinone protects against cold storage injury of renal tubular cells and rat kidneys
    Tanecia Mitchell
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    J Pharmacol Exp Ther 336:682-92. 2011

Detail Information

Publications284 found, 100 shown here

  1. pmc Organophosphate pesticide exposure and attention in young Mexican-American children: the CHAMACOS study
    Amy R Marks
    Center for Children s Environmental Health Research, School of Public Health, University of California, Berkeley, Berkeley, California 94720, USA
    Environ Health Perspect 118:1768-74. 2010
    ..Exposure to organophosphate (OP) pesticides, well-known neurotoxicants, has been associated with neurobehavioral deficits in children...
  2. ncbi Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury
    Victoria J Adlam
    Department of Chemistry, University of Otago, Dunedin, New Zealand
    FASEB J 19:1088-95. 2005
    ....
  3. doi Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix
    Helena M Cocheme
    Medical Research Council Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK
    Cell Metab 13:340-50. 2011
    ..Our findings provide approaches to investigate mitochondrial ROS in vivo and suggest that while an increase in overall mitochondrial H(2)O(2) correlates with aging, it may not be causative...
  4. ncbi 99mTc-N-DBODC5, a new myocardial perfusion imaging agent with rapid liver clearance: comparison with 99mTc-sestamibi and 99mTc-tetrofosmin in rats
    Kengo Hatada
    Experimental Cardiology Laboratory, Cardiovascular Division, Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia, USA
    J Nucl Med 45:2095-101. 2004
    ..We sought to compare the myocardial uptake and clearance kinetics and organ biodistribution of (99m)Tc-N-DBODC5 with (99m)Tc-sestamibi and (99m)Tc-tetrofosmin...
  5. pmc The novel phospho-non-steroidal anti-inflammatory drugs, OXT-328, MDC-22 and MDC-917, inhibit adjuvant-induced arthritis in rats
    L Huang
    Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY, USA
    Br J Pharmacol 162:1521-33. 2011
    ..We evaluated the anti-inflammatory efficacy and safety of three novel modified NSAIDs, phospho-aspirin, phospho-ibuprofen and phospho-sulindac...
  6. pmc Phospho-sulindac (OXT-328) combined with difluoromethylornithine prevents colon cancer in mice
    Gerardo G MacKenzie
    Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA
    Cancer Prev Res (Phila) 4:1052-60. 2011
    ..P-S/DFMO has an intricate mechanism of action extending beyond polyamines and including the thioredoxin system, an emerging regulator of chemoprevention. P-S/DFMO merits further evaluation...
  7. pmc Human PON1, a biomarker of risk of disease and exposure
    C E Furlong
    University of Washington, Department of Medicine Div of Medical Genetics, Seattle, WA, United States
    Chem Biol Interact 187:355-61. 2010
    ..Immunolocalization studies of PONs 1, 2 and 3 in nearly all mouse tissues suggest that the functions of PONs 1 and 3 extend beyond the plasma and the HDL particle...
  8. doi Design and synthesis of active site inhibitors of the human farnesyl pyrophosphate synthase: apoptosis and inhibition of ERK phosphorylation in multiple myeloma cells
    Yih Shyan Lin
    Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC, Canada H3A 0B8
    J Med Chem 55:3201-15. 2012
    ..An analogue of this series was used to demonstrate inhibition of the intended biological target, resulting in apoptosis and down-regulation of ERK phosphorylation in human MM cell lines...
  9. doi Neuroprotection by a mitochondria-targeted drug in a Parkinson's disease model
    Anamitra Ghosh
    Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA
    Free Radic Biol Med 49:1674-84. 2010
    ..Collectively, these results indicate that mitochondrial targeting of antioxidants is a promising neuroprotective strategy in this preclinical mouse model of PD...
  10. pmc The mitochondria-targeted antioxidant mitoquinone protects against cold storage injury of renal tubular cells and rat kidneys
    Tanecia Mitchell
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    J Pharmacol Exp Ther 336:682-92. 2011
    ..These findings implicate that MitoQ could potentially be of therapeutic use for reducing organ preservation damage and kidney discardment and/or possibly improving renal function after transplantation...
  11. doi Non-invasive in vivo imaging of vessel calibre in orthotopic prostate tumour xenografts
    Simon Walker-Samuel
    Cancer Research UK and EPSRC Cancer Imaging Centre, The Institute of Cancer Research and Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom
    Int J Cancer 130:1284-93. 2012
    ....
  12. pmc Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy
    Partha Mukhopadhyay
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Free Radic Biol Med 52:497-506. 2012
    ..Because similar compounds seem to be safe in humans, mitochondrially targeted antioxidants may represent a novel therapeutic approach against cisplatin nephrotoxicity...
  13. doi The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/-/ApoE-/- mice
    John R Mercer
    Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Free Radic Biol Med 52:841-9. 2012
    ..These findings strengthen the growing view that elevated mitochondrial ROS contributes to the etiology of the metabolic syndrome and suggest a potential therapeutic role for mitochondria-targeted antioxidants...
  14. ncbi Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology
    M F Ross
    MRC Dunn Human Nutrition Unit, Cambridge, CB2 2XY, UK
    Biochemistry (Mosc) 70:222-30. 2005
    ..Here we review why these molecules are useful in mitochondrial research and outline some of the ways in which they are now being utilized...
  15. doi Bevacizumab plus fotemustine as first-line treatment in metastatic melanoma patients: clinical activity and modulation of angiogenesis and lymphangiogenesis factors
    Michele Del Vecchio
    Unit of Medical Oncology 2, Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Clin Cancer Res 16:5862-72. 2010
    ..To assess the clinical and biological activity of the association of bevacizumab and fotemustine as first-line treatment in advanced melanoma patients...
  16. pmc Association of organophosphate pesticide exposure and paraoxonase with birth outcome in Mexican-American women
    Kim G Harley
    Center for Environmental Research and Children s Health, School of Public Health, University of California, Berkeley, California, United States of America
    PLoS ONE 6:e23923. 2011
    ..We explored whether paraoxonase (PON1), a key enzyme involved in detoxification of OPs, could be an effect modifier in this association...
  17. ncbi Pesticides and their metabolites in the homes and urine of farmworker children living in the Salinas Valley, CA
    Asa Bradman
    Center for Children s Environmental Health Research, School of Public Health, University of California, Berkeley, CA 94720 7380, USA
    J Expo Sci Environ Epidemiol 17:331-49. 2007
    ..The child activity timeline, a novel, low-literacy instrument based on pictures, was successfully used by our participants. Future uses of these data include the development of pesticide exposure models and risk assessment...
  18. doi A mass spectrometry-based method to measure dialkylphosphate degradation products of organophosphorous insecticides in dust and orange juice
    Gayanga Weerasekera
    National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Mailstop F 17, Atlanta, Georgia, USA
    J Environ Monit 11:1345-51. 2009
    ..Evaluation of the conversion of intact pesticides in the samples to DAPs will help us to better understand the contribution of preformed DAPs to urinary DAP concentrations...
  19. pmc Fotemustine as second-line treatment for recurrent or progressive glioblastoma after concomitant and/or adjuvant temozolomide: a phase II trial of Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO)
    Alba A Brandes
    Department of Medical Oncology, Ospedale Bellaria Maggiore, Bologna, Italy
    Cancer Chemother Pharmacol 64:769-75. 2009
    ..Standardized salvage treatment has not yet proved effective in glioblastoma multiforme (GBM) patients who receive prior standard radiotherapy plus concomitant and adjuvant temozolomide...
  20. pmc Phospho-sulindac (OXT-328), a novel sulindac derivative, is safe and effective in colon cancer prevention in mice
    Gerardo G MacKenzie
    Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, New York 11794 8173, USA
    Gastroenterology 139:1320-32. 2010
    ..However, chronic administration of NSAIDs is associated with significant side effects, mainly of the gastrointestinal tract. Given these limitations, we synthesized phospho-sulindac (P-S; OXT-328), a novel sulindac derivative...
  21. pmc Structural basis for transcription inhibition by tagetitoxin
    Dmitry G Vassylyev
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, School of Medicine, Birmingham, Alabama 35294, USA
    Nat Struct Mol Biol 12:1086-93. 2005
    ..Remodeling of the active site by metal ions could be a common theme in the regulation of catalysis by nucleic acid enzymes...
  22. pmc Detection of organophosphate flame retardants in furniture foam and U.S. house dust
    Heather M Stapleton
    Nicholas School of the Environment, Duke University, Durham, North Carolina, USA
    Environ Sci Technol 43:7490-5. 2009
    ..The high prevalence of these chemicals in foam and the high concentrations measured in dust (as high as 1.8 mg/g) warrant further studies to evaluate potential health effects from dust exposure, particularly for children...
  23. pmc House dust concentrations of organophosphate flame retardants in relation to hormone levels and semen quality parameters
    John D Meeker
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, USA
    Environ Health Perspect 118:318-23. 2010
    ..Although widespread human exposure to OP flame retardants is likely, there is a lack of human and animal data on potential health effects...
  24. doi Animal and human studies with the mitochondria-targeted antioxidant MitoQ
    Robin A J Smith
    Department of Chemistry, University of Otago, Dunedin, New Zealand
    Ann N Y Acad Sci 1201:96-103. 2010
    ..MitoQ has now been used in a range of in vivo studies in rats and mice and in two phase II human trials. Here, we review what has been learned from these animal and human studies with MitoQ...
  25. pmc Intercalating nucleic acids containing insertions of 1-O-(1-pyrenylmethyl)glycerol: stabilisation of dsDNA and discrimination of DNA over RNA
    Ulf B Christensen
    Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, DK 5230 Odense M, Denmark
    Nucleic Acids Res 30:4918-25. 2002
    ..Fluorescence measurements show a stronger interaction of the pyrene moiety with DNA than with RNA, indicating intercalation as the stabilising factor in DNA/INA duplexes...
  26. pmc Urinary metabolite concentrations of organophosphorous pesticides, bisphenol A, and phthalates among pregnant women in Rotterdam, the Netherlands: the Generation R study
    Xibiao Ye
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, MD A3 05, PO Box 12233, Research Triangle Park, NC 27709, USA
    Environ Res 108:260-7. 2008
    ..The data indicate that the Generation R study population provides a wide distribution of selected environmental exposures. Reasons for the relatively high levels and possible health effects need investigation...
  27. ncbi The presence of dialkylphosphates in fresh fruit juices: implication for organophosphorus pesticide exposure and risk assessments
    C Lu
    Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    J Toxicol Environ Health A 68:209-27. 2005
    ..In conclusion, urinary DAPs have many limitations when being used as biomarkers for OP pesticides in exposure and risk assessment, and caution should be exercised when interpreting DAPs results...
  28. ncbi Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
    H Jomaa
    Institute of Biochemistry, Academic Hospital Centre, Justus Liebig University, Friedrichstrasse 24, D 35392 Giessen, Germany
    Science 285:1573-6. 1999
    ..Both drugs suppressed the in vitro growth of multidrug-resistant P. falciparum strains. After therapy with these drugs, mice infected with the rodent malaria parasite P. vinckei were cured...
  29. ncbi Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast
    Stuart A Ralph
    Institut Pasteur, Biology of Host Parasite Interactions, 25 rue du Docteur Roux, 75724, Paris, Cedex 15, France
    Nat Rev Microbiol 2:203-16. 2004
  30. pmc Carboxylesterases 1 and 2 hydrolyze phospho-nonsteroidal anti-inflammatory drugs: relevance to their pharmacological activity
    Chi C Wong
    Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, New York 11794 8173, USA
    J Pharmacol Exp Ther 340:422-32. 2012
    ..037). Our results show that carboxylesterase mediates that metabolic inactivation of phospho-NSAIDs, and the inhibition of carboxylesterases improves the efficacy of phospho-NSAIDs in vitro and in vivo...
  31. pmc Urinary concentrations of dialkylphosphate metabolites of organophosphorus pesticides: National Health and Nutrition Examination Survey 1999-2004
    Dana Boyd Barr
    Emory University, Rollins School of Public Health, Atlanta, GA 30322, USA
    Int J Environ Res Public Health 8:3063-98. 2011
    ..However, according to DAP urinary metabolite data, exposures to OP pesticides have declined during the last six years at both the median and 95th percentile levels...
  32. doi The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide-peptidoglycan model of sepsis
    Damon A Lowes
    Academic Unit of Anaesthesia and Intensive Care, School of Medicine, Institute of Medical Sciences, Foresterhill, Aberdeen, UK
    Free Radic Biol Med 45:1559-65. 2008
    ..05), and mitochondrial membrane potential was augmented (P<0.01) in most organs. These findings suggest that the use of mitochondria-targeted antioxidants such as MitoQ may be beneficial in sepsis...
  33. ncbi Is antioxidant potential of the mitochondrial targeted ubiquinone derivative MitoQ conserved in cells lacking mtDNA?
    Chao Lu
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Republic of Singapore
    Antioxid Redox Signal 10:651-60. 2008
    ..Our results elucidate the antioxidant mechanism of MitoQ and suggest that it may be a useful therapeutic for disorders associated with a dysfunctional ETC and increased ROS production...
  34. doi Improved outcome prediction by SPECT myocardial perfusion imaging after CT attenuation correction
    Aju P Pazhenkottil
    Cardiac Imaging, University Hospital Zurich, Zurich, Switzerland
    J Nucl Med 52:196-200. 2011
    ..The aim of this study was to determine the impact of attenuation correction with CT (CT-AC) on the prognostic value of SPECT myocardial perfusion imaging (SPECT MPI)...
  35. doi Influence of 99mTc-tetrofosmin SPECT myocardial perfusion imaging on the prediction of future adverse cardiac events
    Diwakar Jain
    Drexel University College of Medicine, Philadelphia, PA, USA
    J Nucl Cardiol 16:540-8. 2009
    ..The impact of myocardial perfusion imaging (MPI) on prediction of risk for future cardiac events was examined by comparing predictions based on clinical information alone and in combination with MPI findings...
  36. ncbi Susceptibility contrast magnetic resonance imaging determination of fractional tumor blood volume: a noninvasive imaging biomarker of response to the vascular disrupting agent ZD6126
    Simon P Robinson
    Department of Basic Medical Sciences, St George s, University of London, London, United Kingdom
    Int J Radiat Oncol Biol Phys 69:872-9. 2007
    ..To assess tumor fractional blood volume (xi), determined in vivo by susceptibility contrast magnetic resonance imaging (MRI) as a noninvasive imaging biomarker of tumor response to the vascular disrupting agent ZD6126...
  37. pmc Selective uncoupling of individual mitochondria within a cell using a mitochondria-targeted photoactivated protonophore
    Susan Chalmers
    Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK
    J Am Chem Soc 134:758-61. 2012
    ..This also provides a proof of principle for the general temporally and spatially controlled release of bioactive molecules, pharmacophores, or toxins to mitochondria with tissue, cell, or mitochondrion specificity...
  38. ncbi Effects of NAAG peptidase inhibitor 2-PMPA in model chronic pain - relation to brain concentration
    Jens Nagel
    Preclinical R and D, Merz Pharmaceuticals GmbH, Eckenheimer Landstrasse 100, 60318 Frankfurt am Main, Germany
    Neuropharmacology 51:1163-71. 2006
    ..It appears therefore that the observed behavioural effects of 2-PMPA may not be mediated by NAAG nor, in turn, by mGluR3 receptors...
  39. pmc Analysis of the flame retardant metabolites bis(1,3-dichloro-2-propyl) phosphate (BDCPP) and diphenyl phosphate (DPP) in urine using liquid chromatography-tandem mass spectrometry
    E M Cooper
    Nicholas School of the Environment, Duke University, Durham, NC 27708, USA
    Anal Bioanal Chem 401:2123-32. 2011
    ..The presented method is simple and sufficiently sensitive to detect these FR metabolites in humans and may be applied to future studies to increase our understanding of exposure to and potential health effects from FRs...
  40. pmc Synthesis of 2'-O-methyl-RNAs incorporating a 3-deazaguanine, and UV melting and computational studies on its hybridization properties
    Kohji Seio
    Frontier Collaborative Research Center, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama, Japan
    Nucleic Acids Res 34:4324-34. 2006
    ..Computational studies based on ab initio calculations suggest that the weaker hydrogen bonding ability and larger dipole moment of c3G can be the origin of the lower T(m)...
  41. doi Analytical developments and preliminary assessment of human exposure to organophosphate flame retardants from indoor dust
    Nele Van den Eede
    Toxicological Center, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk Antwerp, Belgium
    Environ Int 37:454-61. 2011
    ..Exposure of non-working and working adults to OPFRs appeared to be similar, but in specific work environments, exposure to some OPFRs (e.g. TDCPP) was increased by a factor >5...
  42. pmc Correlation of MRI biomarkers with tumor necrosis in Hras5 tumor xenograft in athymic rats
    Daniel P Bradley
    Discovery Enabling Capabilities and Sciences, AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK
    Neoplasia 9:382-91. 2007
    ..These data on Hras5 tumors suggest that the quantification of hypoperfused voxels might provide a useful biomarker of tumor necrosis...
  43. pmc Is the PentaBDE replacement, tris (1,3-dichloro-2-propyl) phosphate (TDCPP), a developmental neurotoxicant? Studies in PC12 cells
    Laura V Dishaw
    Nicholas School of the Environment, Duke University, Durham, NC 27708, USA
    Toxicol Appl Pharmacol 256:281-9. 2011
    ..Additionally, these data suggest that OPFRs may affect neurodevelopment with similar or greater potency compared to known and suspected neurotoxicants...
  44. pmc Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia-reperfusion: therapeutic potential of mitochondrially targeted antioxidants
    Partha Mukhopadhyay
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Free Radic Biol Med 53:1123-38. 2012
    ..Mitochondrially generated oxidants play a central role in triggering the deleterious cascade of events associated with hepatic I/R, which may be targeted by novel antioxidants for therapeutic advantage...
  45. doi Phosphorus flame retardants: properties, production, environmental occurrence, toxicity and analysis
    Ike van der Veen
    VU University, Institute for Environmental Studies IVM, De Boelelaan 1087, 1081 HV, Amsterdam, The Netherlands
    Chemosphere 88:1119-53. 2012
    ..GC-MS offers a higher selectivity than GC-NPD and the possibility of using isotopically labeled compounds for quantification...
  46. ncbi Microbial degradation of organophosphorus compounds
    Brajesh K Singh
    Environmental Sciences, Macaulay Institute, Craigiebuckler, Aberdeen, UK
    FEMS Microbiol Rev 30:428-71. 2006
    Synthetic organophosphorus compounds are used as pesticides, plasticizers, air fuel ingredients and chemical warfare agents...
  47. ncbi Analysis of inhibition, reactivation and aging kinetics of highly toxic organophosphorus compounds with human and pig acetylcholinesterase
    N Aurbek
    Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937 Munich, Germany
    Toxicology 224:91-9. 2006
    b>Organophosphorus compounds (OP) are in wide spread use as pesticides and highly toxic OP may be used as chemical warfare agents (nerve agents)...
  48. pmc Postillumination isoprene emission: in vivo measurements of dimethylallyldiphosphate pool size and isoprene synthase kinetics in aspen leaves
    Bahtijor Rasulov
    Department of Plant Physiology, University of Tartu, 51010 Tartu, Estonia
    Plant Physiol 149:1609-18. 2009
    ....
  49. ncbi NO-1886 upregulates ATP binding cassette transporter A1 and inhibits diet-induced atherosclerosis in Chinese Bama minipigs
    Chi Zhang
    Institute of Cardiovascular Research, Nanhua University Medical School, Hengyang, Hunan 421001, China
    J Lipid Res 47:2055-63. 2006
    ..These results demonstrate that the mechanism of atherosclerosis inhibition for NO-1886 is associated with its effect on ABCA1...
  50. pmc Treatment of recurrent malignant gliomas with fotemustine monotherapy: impact of dose and correlation with MGMT promoter methylation
    Alessandra Fabi
    Division of Medical Oncology, Regina Elena Cancer Institute, Rome, Italy
    BMC Cancer 9:101. 2009
    ..Also, the impact of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status on fotemustine activity has never been explored in the clinical setting...
  51. doi Functionally relevant coronary artery disease: comparison of 64-section CT angiography with myocardial perfusion SPECT
    Oliver Gaemperli
    Cardiovascular Center, University Hospital Zurich, Ramistrasse 100, NUK C 32, CH 8091 Zurich, Switzerland
    Radiology 248:414-23. 2008
    ....
  52. ncbi Functional genomic of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism
    Lucio G Costa
    Department of Environmental Health, University of Washington, Seattle, Washington 98195, USA
    Annu Rev Med 54:371-92. 2003
    ..A more recent area of investigation, the role of PON1 in drug metabolism, is also discussed. We emphasize the importance of considering both PON1 isoforms and PON1 levels in disease/sensitivity association studies...
  53. pmc 5-Fluoro pyrimidines: labels to probe DNA and RNA secondary structures by 1D 19F NMR spectroscopy
    Barbara Puffer
    Institute of Organic Chemistry, Center for Molecular Biosciences CMBI, University of Innsbruck, 6020 Innsbruck, Austria, Laboratory of Organic Chemistry, ETH Zurich, 8093 Zurich, Switzerland and Max Perutz Laboratories, Vienna Biocenter, University of Vienna, 1030 Vienna, Austria
    Nucleic Acids Res 37:7728-40. 2009
    ..Furthermore, we developed a facile synthetic route towards 5-fluoro cytidine phosphoramidites that enables their convenient site-specific incorporation into oligonucleotides by solid-phase synthesis...
  54. ncbi Neurotoxic disorders of organophosphorus compounds and their managements
    Mahdi Balali-Mood
    Medical Toxicology Center, Imam Reza Hospital, Mashhad University of Medical Sciences, Iran
    Arch Iran Med 11:65-89. 2008
    b>Organophosphorus compounds have been used as pesticides and as chemical warfare nerve agents...
  55. pmc Association of in utero organophosphate pesticide exposure and fetal growth and length of gestation in an agricultural population
    Brenda Eskenazi
    Center for Children s Environmental Health Research, School of Public Health, University of California Berkeley, 94720 7380, USA
    Environ Health Perspect 112:1116-24. 2004
    ..However, despite these observed associations, the rate of preterm delivery in this population (6.4%) was lower than in a U.S. reference population...
  56. ncbi Interaction of the mitochondria-targeted antioxidant MitoQ with phospholipid bilayers and ubiquinone oxidoreductases
    Andrew M James
    Medical Research Council Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 2XY, United Kingdom
    J Biol Chem 282:14708-18. 2007
    ..These findings will facilitate the rational design of future mitochondria-targeted molecules...
  57. ncbi Low-level exposures to organophosphorus esters and peripheral nerve function
    Marcello Lotti
    Universita degli Studi di Padova, Dipartimento di Medicina Ambientale e Sanità Pubblica, Azienda Ospedaliera, Via Giustiniani 2, 35148 Padua, Italy
    Muscle Nerve 25:492-504. 2002
    ..It is concluded that there is no evidence of peripheral nerve dysfunction caused by low-level prolonged exposures to organophosphate insecticides or nerve agents...
  58. pmc Validation of PON1 enzyme activity assays for longitudinal studies
    Karen Huen
    Center for Children s Environmental Health, School of Public Health, University of California, Berkeley, CA 94720 7360, United States
    Clin Chim Acta 402:67-74. 2009
    ..Length of sample storage, temperature and other factors may influence variability of PON1 measurements, especially in longitudinal studies...
  59. ncbi Detoxification of organophosphate nerve agents by bacterial phosphotriesterase
    Eman Ghanem
    Department of Chemistry, Texas A and M University, P O Box 30012, College Station, TX 77843 3012, USA
    Toxicol Appl Pharmacol 207:459-70. 2005
    ..In this review, the catalytic properties and potential applications of this remarkable enzyme are discussed...
  60. pmc Predicting outcome using butyrylcholinesterase activity in organophosphorus pesticide self-poisoning
    M Eddleston
    Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, and Clinical Pharmacology Unit, University of Edinburgh, UK
    QJM 101:467-74. 2008
    ..Previous studies have been confounded by the inclusion of multiple insecticides with differing inhibitory kinetics...
  61. pmc Correspondence: preformed biomarkers in produce inflate human organophosphate exposure assessments
    Robert I Krieger
    Environ Health Perspect 111:A688-9; author reply A89-91. 2003
  62. pmc Role of CD8(+) lymphocytes in control of simian immunodeficiency virus infection and resistance to rechallenge after transient early antiretroviral treatment
    J D Lifson
    Retroviral Pathogenesis Laboratory, AIDS Vaccine Program, SAIC Frederick, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    J Virol 75:10187-99. 2001
    ..The results help establish the underlying feasibility of efforts to develop vaccines for the prevention of AIDS, although the exact nature of the protective host responses involved remains to be elucidated...
  63. ncbi Acetylcholinesterase inhibition: does it explain the toxicity of organophosphorus compounds?
    Donald M Maxwell
    US Army Medical Research Institute of Chemical Defense, 3100 Ricketts Point Road, Aberdeen Proving Ground, MD 21010 5400, USA
    Arch Toxicol 80:756-60. 2006
    ....
  64. ncbi Rapid multiresidue determination of organochlorine and organophosphorus compounds in human serum by solid-phase extraction and gas chromatography coupled to tandem mass spectrometry
    E Pitarch
    Analytical Chemistry, Experimental Sciences Dept, University Jaume I, PO Box 8029 AP, 12080 Castellon, Spain
    Anal Bioanal Chem 376:189-97. 2003
    ..The method was applied to several serum samples obtained from farmers devoted to citrus crop production. Chlorpyrifos, HCB, p, p'-DDE and the higher chlorinated PCBs (153, 138 and 180) were the most frequently detected compounds...
  65. ncbi Administration of 9-[2-(phosphonomethoxy)propyl]adenine (PMPA) for prevention of perinatal simian immunodeficiency virus infection in rhesus macaques
    K K Van Rompay
    California Regional Primate Research Center, University of California, Davis 95616, USA
    AIDS Res Hum Retroviruses 14:761-73. 1998
    ..Our data demonstrate that PMPA treatment can reduce perinatal SIV infection and suggest that similar strategies may also be effective against HIV...
  66. ncbi Biotransformation of organophosphorus compounds
    M Jokanovic
    Department of Toxicology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11000, Belgrade, Yugoslavia
    Toxicology 166:139-60. 2001
    This study reviews current understanding of mechanisms of biotransformation of organophosphorus compounds (OPC)...
  67. doi A multi-institutional phase II study on second-line Fotemustine chemotherapy in recurrent glioblastoma
    Maria Grazia Fabrini
    Radiotherapy Division of Pisa University Hospital, Pisa, Italy
    J Neurooncol 92:79-86. 2009
    ..1 months; PFS-6 was 52% and median overall survival from primary diagnosis was 24.5 months, with few manageable haematological toxicities. Fotemustine was safe and effective as second-line chemotherapy in recurrent glioblastoma...
  68. doi Histone deacetylase inhibitors: the anticancer, antimetastatic and antiangiogenic activities of AN-7 are superior to those of the clinically tested AN-9 (Pivanex)
    Nataly Tarasenko
    Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Beilinson Campus, Petach Tikva 49100, Israel
    Clin Exp Metastasis 25:703-16. 2008
    ..02). Both AN-7 and AN-9 exhibited antimetastatic and antiangiogenic activities by reducing vascularization, bFGF expression and HIF-1alpha. Yet, AN-7 was more potent than AN-9...
  69. ncbi Pesticides and susceptible populations: people with butyrylcholinesterase genetic variants may be at risk
    O Lockridge
    University of Nebraska Medical Center, Eppley Institute, Omaha 68198 6805, USA
    Neurotoxicology 21:113-26. 2000
    ..More studies are needed to strengthen the hypothesis that people with genetic variants of BChE are at higher risk of intoxication from pesticides...
  70. doi Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice
    Sergio Rodriguez-Cuenca
    Department of Clinical Biochemistry, University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Cambridge CB2 0QQ, UK
    Free Radic Biol Med 48:161-72. 2010
    ..Therefore, MitoQ does not act as a pro-oxidant in vivo. These findings indicate that mitochondria-targeted antioxidants can be safely administered long-term to wild-type mice...
  71. pmc A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis
    S Takahashi
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo ku, Tokyo 113 0032, Japan
    Proc Natl Acad Sci U S A 95:9879-84. 1998
    ..coli...
  72. ncbi Differentiation of resting human peripheral blood gamma delta T cells toward Th1- or Th2-phenotype
    D Wesch
    Institute of Immunology, University Hospital Kiel, D-24105 Kiel, Germany
    Cell Immunol 212:110-7. 2001
    ..These results indicate that the major subset of human gamma delta T cells can be polarized into either Th1 or Th2 cytokine pattern depending on the cytokine milieu in which contact with antigen occurs...
  73. doi Hydrolysis of organophosphorus compounds by microbial enzymes
    Casey M Theriot
    Department of Microbiology, North Carolina State University, 4548 Thomas Hall, Campus Box 7615, Raleigh, NC 27695 7615, USA
    Appl Microbiol Biotechnol 89:35-43. 2011
    ..Current and future potential applications of these enzymes in the hydrolysis of OP compounds are also addressed...
  74. doi High fidelity of base pairing by 2-selenothymidine in DNA
    Abdalla E A Hassan
    Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, USA
    J Am Chem Soc 132:2120-1. 2010
    ..Furthermore, this Se-atom-specific substitution and probing are useful for X-ray crystal structure and function studies of nucleic acids...
  75. ncbi Inhibition, reactivation and aging kinetics of highly toxic organophosphorus compounds: pig versus minipig acetylcholinesterase
    F Worek
    Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937 Munich, Germany
    Toxicology 244:35-41. 2008
    ..The generated data indicate comparable kinetic properties of pig and minipig AChE and may provide a kinetic basis for extrapolation of data from pig studies to humans...
  76. pmc The nonmevalonate pathway supports both monoterpene and sesquiterpene formation in snapdragon flowers
    Natalia Dudareva
    Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907, USA
    Proc Natl Acad Sci U S A 102:933-8. 2005
    ..The trafficking of IPP occurs unidirectionally from the plastids to cytosol. The MEP pathway operates in a rhythmic manner controlled by the circadian clock, which determines the rhythmicity of terpenoid emission...
  77. ncbi Optical organophosphorus biosensor consisting of acetylcholinesterase/viologen hetero Langmuir-Blodgett film
    J W Choi
    Department of Chemical Engineering, Sogang University, C P O Box 1142, Seoul 100 611, South Korea
    Biosens Bioelectron 16:937-43. 2001
    ..of an acetylcholinesterase (AChE)-immobilized Langmuir-Blodgett (LB) film was developed to detect organophosphorus compounds in contaminated water...
  78. pmc Organic diets significantly lower children's dietary exposure to organophosphorus pesticides
    Chensheng Lu
    Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    Environ Health Perspect 114:260-3. 2006
    ..To our knowledge, this is the first study to employ a longitudinal design with a dietary intervention to assess children's exposure to pesticides. It provides new and persuasive evidence of the effectiveness of this intervention...
  79. doi Dialkylphosphates (DAPs) in fruits and vegetables may confound biomonitoring in organophosphorus insecticide exposure and risk assessment
    Xiaofei Zhang
    Personal Chemical Exposure Program, Environmental Toxicology Graduate Program, and infoscientific com, Inc, Manassas, Virginia 20111, USA
    J Agric Food Chem 56:10638-45. 2008
    ..DAPs are more persistent in plants and produce at routinely measured levels than their parent OP insecticides...
  80. ncbi Metabolites of organophosphorous insecticides in urine specimens from inhabitants of a residential area
    U Heudorf
    Department of Environmental Medicine and Hygiene, Public Health Authorities of the City of Frankfurt am Main, Brachbarstr. 18-22, Frankfurt, D-60311, Germany
    Environ Res 86:80-7. 2001
    ..This observation calls for further investigation...
  81. doi Preparation of ethylene gas and comparison of ethylene responses induced by ethylene, ACC, and ethephon
    Wei Zhang
    National Key Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
    Plant Physiol Biochem 48:45-53. 2010
    ..For laboratories that do not have an ethylene tank, ethylene gas can be easily prepared by a chemical approach without further purification...
  82. ncbi Merging models and biomonitoring data to characterize sources and pathways of human exposure to organophosphorus pesticides in the Salinas Valley of California
    Thomas E McKone
    Lawrence Berkeley National Laboratory, Berkeley, California, Center for Children s Environmental Health Research, School of Public Health, University of California, Berkeley, California, USA
    Environ Sci Technol 41:3233-40. 2007
    ..These results show that mass-balance models can estimate exposures for OP pesticides within the range measured by biological monitoring...
  83. ncbi NO-1886 decreases ectopic lipid deposition and protects pancreatic beta cells in diet-induced diabetic swine
    W Yin
    Department of Biochemistry and Biotechnology, Nanhua University School of Life Sciences and Technology, Hengyang, Hunan 421001, China
    J Endocrinol 180:399-408. 2004
    ..Therefore, NO-1886 is potentially beneficial for the treatment of insulin-resistance syndrome...
  84. ncbi Organ biodistribution and myocardial uptake, washout, and redistribution kinetics of Tc-99m N-DBODC5 when injected during vasodilator stress in canine models of coronary stenoses
    Kengo Hatada
    Second Department of Internal Medicine, Cardiovascular Division, Kansai Medical University Takii Hospital Moriguchi City, Osaka, Japan
    J Nucl Cardiol 13:779-90. 2006
    ....
  85. ncbi Diffusion-weighted and macromolecular contrast enhanced MRI of tumor response to antivascular therapy with ZD6126
    Jens Vogel-Claussen
    Johns Hopkins University In Vivo Cellular And Molecular Imaging Center Program, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cancer Biol Ther 6:1469-75. 2007
    ..Both diffusion and vascular imaging are useful noninvasive techniques to detect response of tumors to antivascular therapy with ZD6126 in the DU-145 human prostate cancer xenograft model...
  86. ncbi Fluorescent detection of chemical warfare agents: functional group specific ratiometric chemosensors
    Shi Wei Zhang
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 125:3420-1. 2003
    ..Very weak emission was observed by the addition of HCl. Another indicator based on pyridyl naphthalene exhibits a large shift in its emission spectrum after reaction with DFP, which provides for quantitative ratiometric detection...
  87. doi Lecture: fotemustine in brain tumors
    A Silvani
    Neuro Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 11 Via Celoria, 20133 Milan, Italy
    Neurol Sci 32:S255-7. 2011
    ..Recently, some authors reported the interesting results of a multicenter study on recurrent glioblastoma multiforme patients combining FTMS with new antiangiogentic agent bevacizumab...
  88. doi Occurrence of organophosphorus and carbamate pesticide residues in surface water samples from the Rangpur district of Bangladesh
    Alamgir Zaman Chowdhury
    Agrochemicals and Environmental Research Division, Institute of Food and Radiation Biology, Atomic Energy Research Establishment, Ganakbari, Savar, G P O BOX 3787, Dhaka, 1349, Bangladesh
    Bull Environ Contam Toxicol 89:202-7. 2012
    ..544-0.895, 0.949-1.671 and 0-0.195 μg/L, respectively. This result indicates that the general public living in the area of Rangpur is at high risk of pesticide exposure from contaminated waters in the environment...
  89. doi Fetal effects of environmental exposure of pregnant women to organophosphorus compounds in a rural farming community in Sri Lanka
    Nirma Samarawickrema
    Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka
    Clin Toxicol (Phila) 46:489-95. 2008
    The possible deleterious effects of low-grade, chronic environmental and occupational exposure to organophosphorus compounds (OPCs) are not well documented.
  90. ncbi The anticancer prodrugs of butyric acid AN-7 and AN-9, possess antiangiogenic properties
    Diana Blank-Porat
    Felsenstein Center for Medical Research, Tel Aviv University Beilinson Campus, Petach Tikva 49100, Israel
    Cancer Lett 256:39-48. 2007
    ..Herein, we show that the anticancer activity of AN-7 and AN-9 can be attributed in part to their antiangiogenic activities suggesting potential therapeutic benefits for prostate cancer patients...
  91. ncbi Organophosphate exposures in the United States: a longitudinal analysis of incidents reported to poison centers
    Daniel L Sudakin
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon 97331 6502, USA
    J Toxicol Environ Health A 70:141-7. 2007
    ..The results of this investigation are consistent with other studies that have reported that regulatory restriction of access to pesticide formulations may have a significant impact on the number of human exposure incidents...
  92. ncbi Assessment of organophosphorous pesticide exposures in the diets of preschool children in Washington State
    Richard A Fenske
    Department of Environmental Health, University of Washington, Box 357234, Seattle 98195 7234, USA
    J Expo Anal Environ Epidemiol 12:21-8. 2002
    ..7 microg/kg/day was exceeded by one subject during one sampling event. This subject's cumulative daily dose of chlorpyrifos equivalents was estimated to be 2.5 microg/kg/day...
  93. pmc A new schedule of fotemustine in temozolomide-pretreated patients with relapsing glioblastoma
    Raffaele Addeo
    Oncology Department, S Giovanni di Dio Hospital, ASL Napoli2 Nord Via Giovanni XXIII, 80028 Frattaminore, Naples, Italy
    J Neurooncol 102:417-24. 2011
    ..The study demonstrates that FTM has therapeutic efficacy as single-drug second-line chemotherapy with a favorable safety profile...
  94. pmc Derivatization of DNAs with selenium at 6-position of guanine for function and crystal structure studies
    Jozef Salon
    Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA
    Nucleic Acids Res 36:7009-18. 2008
    ..Furthermore, this novel selenium modification of nucleic acids can be used to investigate chemogenetics and structure of nucleic acids and their protein complexes...
  95. doi Biomarker measurements of concurrent exposure to multiple environmental chemicals and chemical classes in children
    Ken Sexton
    Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Brownsville, Texas 78520, USA
    J Toxicol Environ Health A 74:927-42. 2011
    ..In addition, levels of cotinine in urine indicate that more than half the children were regularly exposed to environmental tobacco smoke, with the upper 10th percentile exposed to relatively high concentrations...
  96. doi Solid phase microextraction using new sol-gel hybrid polydimethylsiloxane-2-hydroxymethyl-18-crown-6-coated fiber for determination of organophosphorous pesticides
    Wan Aini Wan Ibrahim
    Separation Science and Technology Group SepSTec, Ibnu Sina Institute for Fundamental Science Studies, Universiti Teknologi Malaysia, 81310 UTM Skudai, Johor Bahru, Johor, Malaysia
    J Chromatogr A 1217:4890-7. 2010
    ..Percentage recovery of OPPs from strawberry, green apple and grape samples with the new hybrid sol-gel SPME material ranged from 65 to 125% with good precision of the method (%RSD) ranging from 0.3 to 7.4%...
  97. pmc Biosynthesis of terpenes: studies on 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase
    Petra Adam
    Lehrstuhl fur Organische Chemie und Biochemie, Technische Universitat Munchen, Lichtenbergstrasse 4, D 85747 Garching, Germany
    Proc Natl Acad Sci U S A 99:12108-13. 2002
    ..The low intrinsic catalytic activities of wild-type E. coli cell extract and isolated chromoplasts of red pepper (Capsicum annuum) are enhanced by the addition of purified recombinant IspH protein...
  98. doi New reconstruction algorithm allows shortened acquisition time for myocardial perfusion SPECT
    Ines Valenta
    Cardiac Imaging, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland
    Eur J Nucl Med Mol Imaging 37:750-7. 2010
    ..We aimed to validate a new iterative reconstruction (IR) algorithm for SPECT MPI allowing shortened acquisition time (HALF time) while maintaining image quality vs. standard full time acquisition (FULL time)...
  99. doi Diagnostic accuracy of computed tomography coronary angiography and evaluation of stress-only single-photon emission computed tomography/computed tomography hybrid imaging: comparison of prospective electrocardiogram-triggering vs. retrospective gating
    Lars Husmann
    Cardiovascular Center, University Hospital Zurich, Zurich, Switzerland
    Eur Heart J 30:600-7. 2009
    ..retrospective ECG-gating...
  100. ncbi Photochemically induced RNA and DNA abasic sites
    Pascal A Küpfer
    Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland
    Nucleosides Nucleotides Nucleic Acids 26:1177-80. 2007
    ..Another building block which releases a 2'-O-methylated abasic site upon UV radiation is also described...
  101. ncbi Three-dimensional fusion of coronary arteries with myocardial perfusion distributions: clinical validation
    Tracy L Faber
    Department of Radiology, Emory University, Atlanta, Georgia 30322, USA
    J Nucl Med 45:745-53. 2004
    ..Myocardial mass at risk was used as a unique measure to validate the accuracy of the unification...

Research Grants158 found, 100 shown here

  1. Age and sex effects on nerve agent damage to the brain and antidotal therapies
    EDSON ALBUQUERQUE; Fiscal Year: 2007
    The nerve agents soman, sarin and VX are organophosphorus compounds (OPs) chemically related to, but far more toxic than OP insecticides...
  2. PEG-MODIFIED ENZYMES FOR IN-VIVO DECON OF OP TOXINS
    KEITH LEJEUNE; Fiscal Year: 2003
    ..Several known enzymes exhibit hydrolytic activity on target organophosphorus compounds including nerve agent chemical weapons such as sarin and soman as well as many commercially available ..
  3. H-Phosphinic Acids in the Preparation of Active Organophosphorus Compounds
    Jean Luc Montchamp; Fiscal Year: 2007
    ..Thus, beyond the scope of this proposal, some of the chemistry detailed therein should make a significant contribution to the realm of phosphorus-based medicinal chemistry in general. ..
  4. fMRI Assessment of Organophosphate Neurotoxicity
    Steven Bird; Fiscal Year: 2007
    ..aims of this investigation focus on characterizing the central nervous system physiologic effects of organophosphorus compounds. The candidate has chosen Dr. Craig F. Ferris Ph.D. as a mentor for this project...
  5. Neuropharmacology of GHB discrimination
    Wouter Koek; Fiscal Year: 2010
    ..Increased knowledge about the activation and modulation of GABAB systems will help to develop effective approaches to treating sleep-, drug abuse-, and other CNS disorders. ..
  6. Neuropharmacology of GHB discrimination
    Wouter Koek; Fiscal Year: 2005
    ..By identifying the role of specific receptors in abuse-related effects of GHB, future studies may be better able to develop specific, pharmacologically targeted therapies for GHB abuse. ..
  7. Discriminative Stimulus Effects of Alcohol in Mice
    Wouter Koek; Fiscal Year: 2007
    ..This future research will increase our understanding of risk factors for alcoholism and drug abuse and will help the development of effective approaches to prevention and treatment. ..
  8. Vulnerability to Opioids: A Mouse Model
    Wouter Koek; Fiscal Year: 2010
    ....
  9. Neuropharmacology of GHB discrimination
    Wouter Koek; Fiscal Year: 2007
    ..Increased knowledge about the activation and modulation of GABAB systems will help to develop effective approaches to treating sleep-, drug abuse-, and other CNS disorders. ..
  10. ENHANCING RADIATION THERAPY: VASCULAR TARGETING AGENTS
    Dietmar Siemann; Fiscal Year: 2007
    ....
  11. Combining Anti-Angiogenesis Strategies and Radiotherapy
    Dietmar W Siemann; Fiscal Year: 2010
    ..Experiments are designed to investigate the mechanisms underlying the interaction between such therapies and to develop approaches that would maximize the anti-tumor efficacy of such combined treatments. ..
  12. RADIATION AND DRUG EFFECTS ON TUMOR CELL SUBPOPULATIONS
    Dietmar Siemann; Fiscal Year: 2001
    ..Ultimately we hope that these approaches can be reliably developed to an extent where the use of human tumor biopsy material may lead to radiotherapy treatments more tailored to the individual patient. ..
  13. Combining Anti Angiogenesis Strategies and Radiotherapy
    Dietmar Siemann; Fiscal Year: 2005
    ..We believe that these studies will provide essential insights into the therapeutic utility of employing antiangiogenic treatment strategies as adjuvants to radiotherapy. ..
  14. DRUGS AND DEVELOPMENT OF ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 1980
    ....
  15. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 1992
    ....
  16. ETHANOL AND PHOSPHOINOSITIDES DURING BRAIN DEVELOPMENT
    LUCIO COSTA; Fiscal Year: 2000
    ..2. To investigate the molecular pathways involved in the observed inhibition by ethanol of the mitogenic action of acetylcholine in astrocytes. ..
  17. Developmental neurotoxicity of ethanol
    LUCIO COSTA; Fiscal Year: 2009
    ..Altogether, these studies are aimed at elucidating novel aspects of the communication between astrocytes and neurons and at characterizing new mechanisms involved in the developmental neurotoxicity of ethanol. ..
  18. ENHANCING RADIATION THERAPY: VASCULAR TARGETING AGENTS
    Dietmar W Siemann; Fiscal Year: 2010
    ..Experiments are designed to investigate how to deliver such therapies for maximum antitumor efficacy as well as determining the potential of developing predictive indicators of their treatment response. ..
  19. Fetal & Adolescent Nicotine Effects on CNS 5HT Systems
    Theodore Slotkin; Fiscal Year: 2003
    ..abstract_text> ..
  20. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 2003
    ....