methylmercury compounds

Summary

Summary: Organic compounds in which mercury is attached to a methyl group.

Top Publications

  1. ncbi The toxicology of mercury--current exposures and clinical manifestations
    Thomas W Clarkson
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    N Engl J Med 349:1731-7. 2003
  2. ncbi Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury
    P Grandjean
    Institute of Community Health, Odense University, Denmark
    Neurotoxicol Teratol 19:417-28. 1997
  3. pmc Methylmercury and brain development: imprecision and underestimation of developmental neurotoxicity in humans
    Philippe Grandjean
    Harvard School of Public Health, Boston, MA, USA
    Mt Sinai J Med 78:107-18. 2011
  4. ncbi Blood mercury levels in US children and women of childbearing age, 1999-2000
    Susan E Schober
    National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD 20782, USA
    JAMA 289:1667-74. 2003
  5. pmc Balancing the benefits of n-3 polyunsaturated fatty acids and the risks of methylmercury exposure from fish consumption
    Kathryn R Mahaffey
    Department of Occupational and Environmental Health, George Washington University School of Public Health, Washington DC, USA
    Nutr Rev 69:493-508. 2011
  6. pmc Mercury exposure and risk of cardiovascular disease in two U.S. cohorts
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    N Engl J Med 364:1116-25. 2011
  7. pmc Blood organic mercury and dietary mercury intake: National Health and Nutrition Examination Survey, 1999 and 2000
    Kathryn R Mahaffey
    Office of Science Coordination and Policy, Office of Prevention, Pesticides and Toxic Substances, U S Environmental Protection Agency, 1200 Pennsylvania Avenue, Washington, DC 20460, USA
    Environ Health Perspect 112:562-70. 2004
  8. pmc Oxidative stress in MeHg-induced neurotoxicity
    Marcelo Farina
    Departamento de Bioquimica, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Florianopolis, SC, Brazil
    Toxicol Appl Pharmacol 256:405-17. 2011
  9. ncbi Sensitivity of dopaminergic neuron differentiation from stem cells to chronic low-dose methylmercury exposure
    Bastian Zimmer
    Doerenkamp Zbinden Chair of in vitro Toxicology and Biomedicine, Department of Biology, University of Konstanz, D 78457 Konstanz, Germany
    Toxicol Sci 121:357-67. 2011
  10. ncbi Ranking the contributions of commercial fish and shellfish varieties to mercury exposure in the United States: implications for risk communication
    Edward Groth
    Groth Consulting Services, 75 Clifford Avenue, Pelham, NY 10803 1702, USA
    Environ Res 110:226-36. 2010

Detail Information

Publications286 found, 100 shown here

  1. ncbi The toxicology of mercury--current exposures and clinical manifestations
    Thomas W Clarkson
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    N Engl J Med 349:1731-7. 2003
  2. ncbi Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury
    P Grandjean
    Institute of Community Health, Odense University, Denmark
    Neurotoxicol Teratol 19:417-28. 1997
    ..The effects on brain function associated with prenatal methylmercury exposure therefore appear widespread, and early dysfunction is detectable at exposure levels currently considered safe...
  3. pmc Methylmercury and brain development: imprecision and underestimation of developmental neurotoxicity in humans
    Philippe Grandjean
    Harvard School of Public Health, Boston, MA, USA
    Mt Sinai J Med 78:107-18. 2011
    ..The experience obtained with methylmercury should therefore be taken into account when evaluating the evidence for other substances suspected of being neurotoxic...
  4. ncbi Blood mercury levels in US children and women of childbearing age, 1999-2000
    Susan E Schober
    National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD 20782, USA
    JAMA 289:1667-74. 2003
    ..The fetus is most sensitive to the adverse effects of exposure. The extent of exposure to methylmercury in US women of reproductive age is not known...
  5. pmc Balancing the benefits of n-3 polyunsaturated fatty acids and the risks of methylmercury exposure from fish consumption
    Kathryn R Mahaffey
    Department of Occupational and Environmental Health, George Washington University School of Public Health, Washington DC, USA
    Nutr Rev 69:493-508. 2011
    ..A framework for providing dietary advice for women of childbearing age on how to maximize the dietary intake of n-3 PUFAs while minimizing MeHg exposures is suggested...
  6. pmc Mercury exposure and risk of cardiovascular disease in two U.S. cohorts
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    N Engl J Med 364:1116-25. 2011
    ..Beneficial effects of the ingestion of fish and selenium may also modify such effects...
  7. pmc Blood organic mercury and dietary mercury intake: National Health and Nutrition Examination Survey, 1999 and 2000
    Kathryn R Mahaffey
    Office of Science Coordination and Policy, Office of Prevention, Pesticides and Toxic Substances, U S Environmental Protection Agency, 1200 Pennsylvania Avenue, Washington, DC 20460, USA
    Environ Health Perspect 112:562-70. 2004
    ....
  8. pmc Oxidative stress in MeHg-induced neurotoxicity
    Marcelo Farina
    Departamento de Bioquimica, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Florianopolis, SC, Brazil
    Toxicol Appl Pharmacol 256:405-17. 2011
    ....
  9. ncbi Sensitivity of dopaminergic neuron differentiation from stem cells to chronic low-dose methylmercury exposure
    Bastian Zimmer
    Doerenkamp Zbinden Chair of in vitro Toxicology and Biomedicine, Department of Biology, University of Konstanz, D 78457 Konstanz, Germany
    Toxicol Sci 121:357-67. 2011
    ..Thus, transcriptional profiling in differentiating mESC identified a subpopulation of neurons affected by MeHg, and a pharmacological intervention was identified that specifically protected these cells...
  10. ncbi Ranking the contributions of commercial fish and shellfish varieties to mercury exposure in the United States: implications for risk communication
    Edward Groth
    Groth Consulting Services, 75 Clifford Avenue, Pelham, NY 10803 1702, USA
    Environ Res 110:226-36. 2010
    ..I have sorted the 51 seafood varieties into six categories based on mercury levels, as a framework for improving risk communication in this regard...
  11. ncbi Methylmercury-induced neurotoxicity and apoptosis
    Sandra Ceccatelli
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Chem Biol Interact 188:301-8. 2010
    ..In this paper, we provide an overview of recent findings on methylmercury-induced neurotoxicity and cell death pathways that have been described in neural and endocrine cell systems...
  12. ncbi Neurotoxicity and molecular effects of methylmercury
    A F Castoldi
    University of Pavia and Salvatore Maugeri Foundation, Pavia, Italy
    Brain Res Bull 55:197-203. 2001
    ..Here some examples of MeHg molecular effects occurring at low doses/concentrations are presented...
  13. ncbi Adverse effects from environmental mercury loads on breeding common loons
    David C Evers
    BioDiversity Research Institute, 19 Flaggy Meadow Road, Gorham, ME 04038, USA
    Ecotoxicology 17:69-81. 2008
    ..Standardized monitoring programs are needed to determine if population sinks occur elsewhere and to track aquatic ecosystem responses to changes in Hg emissions and deposition...
  14. ncbi Prenatal methylmercury exposure from ocean fish consumption in the Seychelles child development study
    Gary J Myers
    Department of Neurology, National Institute for Child Health and Development, National Institutes of Health, Department of Health and Human Services, Bethesda, USA
    Lancet 361:1686-92. 2003
    ..The most common form of prenatal exposure is maternal fish consumption, but whether such exposure harms the fetus is unknown. We aimed to identify adverse neurodevelopmental effects in a fish-consuming population...
  15. pmc Evaluation of the cardiovascular effects of methylmercury exposures: current evidence supports development of a dose-response function for regulatory benefits analysis
    Henry A Roman
    Industrial Economics Inc, Cambridge, Massachusetts 02140, USA
    Environ Health Perspect 119:607-14. 2011
    ..A growing body of evidence suggests that MeHg exposure can also lead to increased risks of adverse cardiovascular impacts in exposed populations...
  16. ncbi Dietary selenium's protective effects against methylmercury toxicity
    Nicholas V C Ralston
    Energy and Environmental Research Center, University of North Dakota, 15 North 23rd Street, Grand Forks, ND 58202, USA
    Toxicology 278:112-23. 2010
    ..Further studies of these relationships are needed to assist regulatory agencies in protecting and improving child health...
  17. pmc Postnatal exposure to methyl mercury from fish consumption: a review and new data from the Seychelles Child Development Study
    Gary J Myers
    University of Rochester School of Medicine and Dentistry, Department of Neurology, Rochester, NY, United States
    Neurotoxicology 30:338-49. 2009
    ....
  18. ncbi Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity
    M Aschner
    Departments of Pediatrics and Pharmacology, Vanderbilt University Medical Center, B3307 Medical Center North, Nashville, TN 37232, USA
    Braz J Med Biol Res 40:285-91. 2007
    ....
  19. ncbi The endocrine effects of mercury in humans and wildlife
    Shirlee W Tan
    US Environmental Protection Agency, Office of Science Coordination and Policy, Washington, DC 20460, USA
    Crit Rev Toxicol 39:228-69. 2009
    ..Greater inclusion of endocrine endpoints in epidemiological and field studies on humans and wildlife will also advance the research in this area...
  20. pmc Mercury methylation from unexpected sources: molybdate-inhibited freshwater sediments and an iron-reducing bacterium
    Emily J Fleming
    Section of Microbiology, 357 Briggs Hall, University of California, Davis, CA 95616, USA
    Appl Environ Microbiol 72:457-64. 2006
    ..We suggest that mercury methylation by iron-reducing bacteria represents a previously unidentified and potentially significant source of this environmental toxin in iron-rich freshwater sediments...
  21. ncbi Hazard assessment of methylmercury toxicity to neuronal induction in embryogenesis using human embryonic stem cells
    Tina C Stummann
    European Centre for the Validation of Alternative Methods ECVAM T P 580, IHCP, JRC, European Commission, via Fermi 2749, 21027 Ispra VA, Italy
    Toxicology 257:117-26. 2009
    ..Overall, our experiments demonstrate that the hESC assay can provide alerts for the adverse effects of MeHg on neuronal induction...
  22. pmc Isothiocyanates reduce mercury accumulation via an Nrf2-dependent mechanism during exposure of mice to methylmercury
    Takashi Toyama
    Doctoral Programs in Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    Environ Health Perspect 119:1117-22. 2011
    ..Methylmercury (MeHg) exhibits neurotoxicity through accumulation in the brain. The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) plays an important role in reducing the cellular accumulation of MeHg...
  23. pmc Negative confounding in the evaluation of toxicity: the case of methylmercury in fish and seafood
    Anna L Choi
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    Crit Rev Toxicol 38:877-93. 2008
    ..Attention should also be paid to the occurrence of negative confounding in other connections...
  24. pmc Comparative toxicology of mercurials in Caenorhabditis elegans
    Matthew K McElwee
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Environ Toxicol Chem 30:2135-41. 2011
    ..In general, MeHgCl was more toxic to C. elegans than HgCl(2), particularly when assaying behaviors that require neuromuscular function...
  25. pmc Temporal increase in organic mercury in an endangered pelagic seabird assessed by century-old museum specimens
    Anh Thu E Vo
    Department of Organismic and Evolutionary Biology, Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 108:7466-71. 2011
    ..These data show that remote seabird colonies in the Pacific basin exhibit temporal changes in methylmercury levels consistent with historical global and recent regional increases in anthropogenic emissions...
  26. pmc Stoichiometric controls of mercury dilution by growth
    Roxanne Karimi
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 104:7477-82. 2007
    ..Our findings show that rapid growth from high-quality food consumption can significantly reduce the accumulation and trophic transfer of MeHg in freshwater food webs...
  27. pmc Response inhibition and error monitoring during a visual go/no-go task in inuit children exposed to lead, polychlorinated biphenyls, and methylmercury
    Olivier Boucher
    Centre de Recherche du Centre Hospitalier Universitaire de Québec, Quebec, Canada
    Environ Health Perspect 120:608-15. 2012
    ..Lead (Pb) and polychlorinated biphenyls (PCBs) are neurotoxic contaminants that have been related to impairment in response inhibition...
  28. ncbi Marine biogeochemical cycling of mercury
    William F Fitzgerald
    Department of Marine Sciences, University of Connecticut, 1080 Shenecosett Road, Groton, Connecticut 06340, USA
    Chem Rev 107:641-62. 2007
  29. ncbi Sensitivity of immature neurons in culture to metal-induced changes in reactive oxygen species and intracellular free calcium
    W R Mundy
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Neurotoxicology 21:1135-44. 2000
    ..These results suggest that there may be inherent differences in the sensitivity of neurons to toxicant-induced increases in ROS and [Ca2+] depending upon age and cell type...
  30. pmc Methyl mercury and inorganic mercury in Swedish pregnant women and in cord blood: influence of fish consumption
    K Ask Björnberg
    Division of Metals and Health, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Environ Health Perspect 111:637-41. 2003
    ..26; p = 0.003), but no association with fish consumption. I-Hg in cord blood (median 0.15 microg/L; range 0.03-0.53 microg/L) increased significantly with increasing number of maternal dental amalgam fillings...
  31. pmc Sources of mercury exposure for U.S. seafood consumers: implications for policy
    Noelle E Selin
    Joint Program on the Science and Policy of Global Change, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 4307, USA
    Environ Health Perspect 118:137-43. 2010
    ..Recent policies attempting to reduce adverse effects of methylmercury exposure from fish consumption in the United States have targeted reductions in anthropogenic emissions from U.S. sources...
  32. pmc Sensitivity of continuous performance test (CPT) at age 14 years to developmental methylmercury exposure
    Jordi Julvez
    Harvard School of Public Health, Boston, MA, USA
    Neurotoxicol Teratol 32:627-32. 2010
    ..When using CPT data as a possible measure of neurotoxicity, test results should therefore be analyzed in regard to time from test initiation and not as overall average reaction times...
  33. pmc Synergistic neurotoxicity induced by methylmercury and quercetin in mice
    Roberta de P Martins
    Departamento de Bioquimica, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Campus Trindade, 88040 900 Florianopolis, SC, Brazil
    Food Chem Toxicol 47:645-9. 2009
    ..The present results indicate that under in vivo conditions quercetin and MeHg cause additive pro-oxidative effects toward the mice cerebellum and that such phenomenon is associated with the observed motor deficit...
  34. ncbi The movement of aquatic mercury through terrestrial food webs
    Daniel A Cristol
    Institute for Integrative Bird Behavior Studies, Department of Biology, College of William and Mary, Williamsburg, VA 23185, USA
    Science 320:335. 2008
    ..Rivers contaminated with mercury may pose a threat to the many bird species that feed on predatory invertebrates in adjacent riparian habitats...
  35. ncbi Activation of TRPC cationic channels by mercurial compounds confers the cytotoxicity of mercury exposure
    Shang Zhong Xu
    Centre for Cardiovascular and Metabolic Research, Hull York Medical School, University of Hull, Hull, HU6 7RX, UK
    Toxicol Sci 125:56-68. 2012
    ..These results indicate that mercurial compounds are activators for TRPC5 and TRPC4 channels. Blockade of TRPC channels could be a novel strategy for preventing mercury-induced cytotoxicity and neurodevelopment impairment...
  36. pmc Genetic variation in glutathione-related genes and body burden of methylmercury
    Karin Schläwicke Engström
    Department of Occupational and Environmental Medicine, Lund University Hospital, Lund, Sweden
    Environ Health Perspect 116:734-9. 2008
    ..One possible explanation is hereditary differences in MeHg metabolism. MeHg is eliminated from the body as a glutathione (GSH) conjugate...
  37. pmc Evidence on the human health effects of low-level methylmercury exposure
    Margaret R Karagas
    Section of Biostatistics and Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA
    Environ Health Perspect 120:799-806. 2012
    ..Despite its global relevance, synthesis of the available literature on low-level MeHg exposure has been limited...
  38. ncbi Effects of 2,3-dimercapto-1-propanesulfonic acid (DMPS) on methylmercury-induced locomotor deficits and cerebellar toxicity in mice
    Márcia C Carvalho
    Departamento de Biologia Celular, Embriologia e Genetica, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Florianopolis, SC, Brazil
    Toxicology 239:195-203. 2007
    ..Histological analyses indicate that these phenomena are related to its capability of removing mercury from cerebellar cortex...
  39. ncbi Methylmercury exposure and health effects in humans: a worldwide concern
    Donna Mergler
    Department of Biological Sciences, Institute for Environmental Sciences, University of Quebec, Montreal, Canada
    Ambio 36:3-11. 2007
    ....
  40. ncbi Intervention study on cardiac autonomic nervous effects of methylmercury from seafood
    Kozue Yaginuma-Sakurai
    Department of Environmental Health Sciences, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Sendai 980 8575, Japan
    Neurotoxicol Teratol 32:240-5. 2010
    ..Rather, long-term exposure to methylmercury may pose a potential risk for cardiac events involving sympathovagal imbalance among fish-consuming populations...
  41. ncbi Gene expression profiling in rat cerebellum following in utero and lactational exposure to mixtures of methylmercury, polychlorinated biphenyls and organochlorine pesticides
    B K Padhi
    Environment and Occupational Toxicology Division, HECSB, Health Canada, Tunney s Pasture, Ottawa, Ontario K1A 0L2, Canada
    Toxicol Lett 176:93-103. 2008
    ....
  42. ncbi Overview of modifiers of methylmercury neurotoxicity: chemicals, nutrients, and the social environment
    Deborah C Rice
    Maine Center for Disease Control and Prevention, Augusta, ME 04333, United States
    Neurotoxicology 29:761-6. 2008
    ..An understanding of the interactions of the multiple factors that determine the final behavioral outcome of exposure to methylmercury is crucial to risk assessment and risk management decisions...
  43. ncbi Effects of environmental methylmercury on the health of wild birds, mammals, and fish
    Anton M Scheuhammer
    National Wildlife Research Centre, Environment Canada, Carleton University, Ottawa
    Ambio 36:12-8. 2007
    ..Other piscivorous species may also benefit from decreased Hg exposure but have not been as extensively studied as the common loon...
  44. pmc Methylmercury induces acute oxidative stress, altering Nrf2 protein level in primary microglial cells
    Mingwei Ni
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Toxicol Sci 116:590-603. 2010
    ..Taken together, our study has demonstrated that microglial cells are exquisitely sensitive to MeHg and respond rapidly to MeHg by upregulating the Nrf2-mediated antioxidant response...
  45. pmc Methylmercury exposure and adverse cardiovascular effects in Faroese whaling men
    Anna L Choi
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 117:367-72. 2009
    ..Methylmercury (MeHg), a worldwide contaminant found in fish and seafood, has been linked to an increased risk of cardiovascular mortality...
  46. ncbi Human mercury exposure and adverse health effects in the Amazon: a review
    Carlos J S Passos
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Brasil
    Cad Saude Publica 24:s503-20. 2008
    ....
  47. pmc Methylmercury toxicity and Nrf2-dependent detoxification in astrocytes
    Ling Wang
    Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Toxicol Sci 107:135-43. 2009
    ..Modulation of Nrf2 by pharmacological modalities should afford a treatment to attenuate MeHg-induced neurotoxicity...
  48. ncbi Dietary and tissue selenium in relation to methylmercury toxicity
    Nicholas V C Ralston
    Energy and Environmental Research Center, University of North Dakota, Grand Forks, ND 58202, United States
    Neurotoxicology 29:802-11. 2008
    ..Therefore, selenoenzymes may be the molecular target of methylmercury toxicity...
  49. pmc Comparative study on the response of rat primary astrocytes and microglia to methylmercury toxicity
    Mingwei Ni
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Glia 59:810-20. 2011
    ..These unique sensitivities appear to be dependent on the cellular thiol status of the particular cell type...
  50. pmc Methylmercury neurotoxicity in Amazonian children downstream from gold mining
    P Grandjean
    Department of Environmental Medicine, Odense University, Odense, Denmark
    Environ Health Perspect 107:587-91. 1999
    ..However, the current mercury pollution seems sufficiently severe to cause adverse effects on brain development...
  51. ncbi A quantitative risk-benefit analysis of changes in population fish consumption
    Joshua T Cohen
    Harvard Center for Risk Analysis, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Prev Med 29:325-34. 2005
    ....
  52. ncbi Mercurial-induced hydrogen peroxide generation in mouse brain mitochondria: protective effects of quercetin
    Jeferson L Franco
    Departamento de Bioquimica, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, 88040 900, Florianopolis, SC, Brazil
    Chem Res Toxicol 20:1919-26. 2007
    ..Taken together, these data render quercetin a promising molecule for pharmacological studies with respects to mercurials' poisoning...
  53. ncbi Tissue specific changes in the expression of glutamate-cysteine ligase mRNAs in mice exposed to methylmercury
    D Diaz
    Department of Environmental Health, Centre for Ecogenetics and Environmental Health, University of Washington, Suite 100, 4225 Roosevelt Way NE, Mail Box 354695, Seattle, WA 98195, USA
    Toxicol Lett 122:119-29. 2001
    ..These results suggest that GLCLc and GLCLr can be differentially regulated in vivo, and that this regulation is tissue dependent in the mouse...
  54. pmc Mercury speciation and total trace element determination of low-biomass biological samples
    Vivien F Taylor
    Trace Element Analysis Core, Dartmouth College, 6105 Fairchild, Hanover, NH 03755, USA
    Anal Bioanal Chem 392:1283-90. 2008
    ..The method also provides further validation of speciation data, by corroborating the sum of the Hg species concentrations with the total Hg concentration...
  55. ncbi Alterations of visual evoked potentials in preschool Inuit children exposed to methylmercury and polychlorinated biphenyls from a marine diet
    Dave Saint-Amour
    Departement d Ophtalmologie, CHU Sainte Justine, 3175, Cote Sainte Catherine, Montreal, Que, Canada H3T 1C5
    Neurotoxicology 27:567-78. 2006
    ..e. at the preschool age. Our findings suggest that VEP can be used as a valuable tool to assess the developmental neurotoxicity of environmental contaminants in fish-eating populations...
  56. pmc Developmental mercury exposure elicits acute hippocampal cell death, reductions in neurogenesis, and severe learning deficits during puberty
    Anthony Falluel-Morel
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    J Neurochem 103:1968-81. 2007
    ..In aggregate, these studies indicate that exposure to one dose of MeHg during the perinatal period acutely induces apoptotic cell death, which results in later deficits in hippocampal structure and function...
  57. ncbi Protective effect of Bacopa monniera on methyl mercury-induced oxidative stress in cerebellum of rats
    Thangarajan Sumathi
    Department of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, Tamil Nadu, India
    Cell Mol Neurobiol 32:979-87. 2012
    ..These findings strongly implicate that BM has potential to protect brain from oxidative damage resulting from MeHg-induced neurotoxicity in rat...
  58. ncbi Methylmercury neurotoxicity is associated with inhibition of the antioxidant enzyme glutathione peroxidase
    Jeferson L Franco
    Departamento de Bioquimica, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Florianopolis, SC 88040 900, Brazil
    Free Radic Biol Med 47:449-57. 2009
    ..These results suggest that GPx is an important target for MeHg-induced neurotoxicity, presumably because this enzyme is essential for counteracting the pro-oxidative effects of MeHg both in vitro and in vivo...
  59. pmc IL-6 release from mouse glia caused by MeHg requires cytosolic phospholipase A2 activation
    Jason Y Chang
    Department of Neurobiology and Developmental Sciences, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Neurosci Lett 461:85-9. 2009
    ..However, these PLA(2) inhibitors did not block MeHg induced GSH depletion. These results suggested that PLA(2) activation was required for MeHg to induce glial IL-6 release...
  60. pmc Spatial patterns of mercury in macroinvertebrates and fishes from streams of two contrasting forested landscapes in the eastern United States
    Karen Riva-Murray
    US Geological Survey, Troy, NY 12180, USA
    Ecotoxicology 20:1530-42. 2011
    ....
  61. pmc Methylmercury: a potential environmental risk factor contributing to epileptogenesis
    Yukun Yuan
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Neurotoxicology 33:119-26. 2012
    ....
  62. ncbi GFAT as a target molecule of methylmercury toxicity in Saccharomyces cerevisiae
    A Naganuma
    Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980 8578, Japan
    FASEB J 14:968-72. 2000
    ..This report is the first to identify the target molecule of methylmercury toxicity in eukaryotic cells...
  63. ncbi Differential signaling pathways following oxidative stress in mutant myotonin protein kinase cDNA-transfected C2C12 cell lines
    F Usuki
    Department of Clinical Medicine, National Institute for Minamata Disease, 4058 18 Hama, Minamata, 867 0008, Japan
    Biochem Biophys Res Commun 267:739-43. 2000
    ..These results suggest that the susceptibility to oxidative stress in mutant MtPK cDNA transformants involves differential signaling pathways evoked following oxidative stress...
  64. ncbi Habitat-specific bioaccumulation of methylmercury in invertebrates of small mid-latitude lakes in North America
    John Chételat
    Groupe de recherche interuniversitaire en limnologie, Departement de sciences biologiques, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    Environ Pollut 159:10-7. 2011
    ..Our findings demonstrate that littoral-pelagic differences in MeHg bioaccumulation are widespread in small mid-latitude lakes...
  65. ncbi Identification of a mechanism by which the methylmercury antidotes N-acetylcysteine and dimercaptopropanesulfonate enhance urinary metal excretion: transport by the renal organic anion transporter-1
    Albert S Koh
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Mol Pharmacol 62:921-6. 2002
    ..This is the first molecular identification of a transport mechanism by which these antidotes may enhance urinary excretion of toxic metals...
  66. pmc Mechanisms of methylmercury-induced neurotoxicity: evidence from experimental studies
    Marcelo Farina
    Departamento de Bioquimica, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Florianopolis, SC, Brazil
    Life Sci 89:555-63. 2011
    ....
  67. pmc Indicators of sediment and biotic mercury contamination in a southern New England estuary
    David L Taylor
    Roger Williams University, Department of Marine Biology, One Old Ferry Road, Bristol, RI 02809, USA
    Mar Pollut Bull 64:807-19. 2012
    ..These results have important implications for the utility of estuarine biota as subjects for mercury monitoring programs...
  68. ncbi Neurobehavioral performance of Inuit children with increased prenatal exposure to methylmercury
    Pal Weihe
    Department of Occupational and Public Health, The Faroese Hospital System, Torshavn, Foroe Islands
    Int J Circumpolar Health 61:41-9. 2002
    ..The data from the present study therefore appears in accordance with other evidence that prenatal or early postnatal exposures to methylmercury may cause subtle neurobehavioral deficits...
  69. ncbi A review of experimental methylmercury toxicity in rats: neuropathology and evidence for apoptosis
    K Nagashima
    Department of Pathology, Hokkaido University School of Medicine, Sapporo, Japan
    Toxicol Pathol 25:624-31. 1997
    ..Evidence of apoptosis involvement in cerebellar degeneration would provide a new viewpoint from which to analyze the selected degeneration of the nervous system in neurotoxicology...
  70. ncbi A ubiquitin-proteasome system is responsible for the protection of yeast and human cells against methylmercury
    Gi Wook Hwang
    Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980 8578, Japan
    FASEB J 16:709-11. 2002
    ..Our results support the hypothesis that MeHg induces the cellular accumulation of a certain protein(s) that causes cell damage and that this protein(s) is degraded after its ubiquitination in proteasomes...
  71. ncbi Neurobehavioral effects of prenatal exposure to methylmercury and PCBs, and seafood intake: neonatal behavioral assessment scale results of Tohoku study of child development
    Keita Suzuki
    Environmental Health Sciences, Tohoku University, Graduate School of Medicine, 2 1 Seiryo machi, Sendai, Miyagi 980 8576, Japan Japan Society for the Promotion of Science, Tokyo, Japan
    Environ Res 110:699-704. 2010
    ..The neurobehavioral effect of prenatal exposure to PCBs remains unclear in our study. Further research is necessary to elucidate interactive effects of methylmercury, PCBs, and n-3 PUFAs, originating from fish, on child neurodevelopment...
  72. ncbi Overexpression of the ubiquitin-conjugating enzyme Cdc34 confers resistance to methylmercury in Saccharomyces cerevisiae
    Takemitsu Furuchi
    Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    Mol Pharmacol 61:738-41. 2002
    ..Our results suggest that ubiquitination system might be involved in protection against the toxicity of mercury compounds, such as methylmercury, in eukaryotic cells...
  73. ncbi Impairment of spermatogenesis in rats by methylmercury: involvement of stage- and cell- specific germ cell apoptosis
    S Homma-Takeda
    Graduate School Doctoral Program in Medical Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Toxicology 169:25-35. 2001
    ..Our results suggest that methylmercury impairs spermatogenesis by germ cell deletion via cell- and stage- specific apoptosis...
  74. pmc Bioaccumulation syndrome: identifying factors that make some stream food webs prone to elevated mercury bioaccumulation
    Darren M Ward
    Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire, USA
    Ann N Y Acad Sci 1195:62-83. 2010
    ..Finally, based on an understanding of the ecological drivers of MeHg accumulation, we identify situations when anthropogenic effects and management practices could significantly exacerbate or ameliorate MeHg accumulation in stream fish...
  75. ncbi Investigation of intracellular factors involved in methylmercury toxicity
    Akira Naganuma
    Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980 8578, Japan
    Tohoku J Exp Med 196:65-70. 2002
    ..It has also been shown that GFAT is the target molecule of methylmercury in yeast cells. These findings provide important clues about the mechanism underlying methylmercury toxicity in mammals...
  76. ncbi Changes in mercury bioaccumulation in an apex predator in response to removal of an introduced competitor
    Jesse M Lepak
    Warner College of Natural Resources, Colorado Cooperative Fish and Wildlife Research Unit, Colorado State University, Fort Collins, CO 80523, USA
    Ecotoxicology 18:488-98. 2009
    ..These data provide evidence for a mechanism (diet shift due to reduced competition) by which changes in food web structure can influence MeHg concentrations in top predators...
  77. ncbi Deleterious effects in mice of fish-associated methylmercury contained in a diet mimicking the Western populations' average fish consumption
    Jean Paul Bourdineaud
    Bordeaux University CNRS, UMR EPOC 5805, Arcachon Marine Station, Place du Docteur Peyneau, Arcachon, 33120, France
    Environ Int 37:303-13. 2011
    ....
  78. ncbi Awake at the switch: improving fish consumption advisories for at-risk women
    Mario F Teisl
    School of Economics, University of Maine, Orono, ME 04469, USA
    Sci Total Environ 409:3257-66. 2011
    ..We conclude a well-designed advisory can successfully transform a complex risk/benefit message into one that leads to appropriate knowledge and behavioral changes...
  79. ncbi Human developmental neurotoxicity of methylmercury: impact of variables and risk modifiers
    Anna F Castoldi
    Toxicology Division, University of Pavia, Via Palestro 26, 27100 Pavia, Italy
    Regul Toxicol Pharmacol 51:201-14. 2008
    ..These factors, together with the notion that some symptoms may ensue or exacerbate with aging, contribute to the difficulties in the definition of safe levels for developmental exposure...
  80. ncbi Attenuated growth of breast-fed children exposed to increased concentrations of methylmercury and polychlorinated biphenyls
    Philippe Grandjean
    Department of Environmental Health, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, USA
    FASEB J 17:699-701. 2003
    ..Thus, in communities with increased contaminant exposures, risks associated with lactational transfer of toxicants to the infant must be considered when judging the benefits of prolonged breast-feeding...
  81. ncbi Methylmercury alters glutamate transport in astrocytes
    M Aschner
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Neurochem Int 37:199-206. 2000
    ..This manuscript details the role of astrocytes in mediating MeHg-induced excitotoxicity, and elaborates on the protective role afforded by metallothioneins (MTs) in attenuating MeHg cytotoxicity...
  82. pmc Fetal and maternal immune responses to methylmercury exposure: a cross-sectional study
    Jennifer F Nyland
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615N Wolfe Street, Baltimore, MD 21205, USA
    Environ Res 111:584-9. 2011
    ..However, unlike previous data from adult males and non-pregnant females, we found no evidence that antinuclear and antinucleolar autoantibody titer is a reliable biomarker of mercury immunotoxicity in this population...
  83. ncbi Disruption of intraneuronal divalent cation regulation by methylmercury: are specific targets involved in altered neuronal development and cytotoxicity in methylmercury poisoning?
    Tobi L Limke
    Department of Pharmacology and Toxicology, Institute for Environmental Toxicology, Michigan State University, B 331 Life Sciences Building, East Lansing, MI 48824 1317, USA
    Neurotoxicology 25:741-60. 2004
    ..In this review, we examine the hypothesis that MeHg affects specific targets to cause disruption of neuronal development and cell death...
  84. ncbi The effects of methylmercury on mitochondrial function and reactive oxygen species formation in rat striatal synaptosomes are age-dependent
    Anne Dreiem
    New York State Department of Health, Wadsworth Center, Albany, New York, 12201, USA
    Toxicol Sci 87:156-62. 2005
    ..These age-dependent differences in susceptibility to MeHg are most likely due to a less efficient ROS detoxifying system and lower activity of mitochondrial enzymes in tissue from young animals...
  85. ncbi Mercury cycling in stream ecosystems. 2. Benthic methylmercury production and bed sediment-pore water partitioning
    Mark Marvin-DiPasquale
    U S Geological Survey, 345 Middlefield Road, Menlo Park, California 94025, USA
    Environ Sci Technol 43:2726-32. 2009
    ....
  86. ncbi Deposition and cycling of sulfur controls mercury accumulation in Isle Royale fish
    Paul E Drevnick
    Department of Zoology, Miami University, Oxford, Ohio 45056, USA
    Environ Sci Technol 41:7266-72. 2007
    ..Therefore, reductions in anthropogenic sulfur emissions may provide a synergistic solution to the mercury problem in sulfate-limited freshwaters...
  87. ncbi Changes in mercury concentrations of segmental maternal hair during gestation and their correlations with other biomarkers of fetal exposure to methylmercury in the Japanese population
    Mineshi Sakamoto
    Department of Epidemiology, National Institute for Minamata Disease, Kumamoto 867 0008, Japan
    Environ Res 106:270-6. 2008
    ..In addition, the segmental maternal hair throughout gestation is essential to obtain important information on MeHg exposure during the different sensitive windows or bolus MeHg exposure during gestation...
  88. pmc Total imprecision of exposure biomarkers: implications for calculating exposure limits
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Am J Ind Med 50:712-9. 2007
    ..Unrecognized imprecision leads to underestimation of the true toxicity of the exposure. We have assessed the total imprecision of exposure biomarkers and the implications for calculation of exposure limits...
  89. ncbi Protective effects of organoselenium compounds against methylmercury-induced oxidative stress in mouse brain mitochondrial-enriched fractions
    D F Meinerz
    Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil
    Braz J Med Biol Res 44:1156-63. 2011
    ....
  90. ncbi An investigation of the effects of methylmercury in rats fed different dietary fats and proteins: testicular steroidogenic enzymes and serum testosterone levels
    Mark J McVey
    Toxicology Research Division, Health Products and Foods Branch, Food Directorate, Health Canada, Sir Fredrick G Banting Research Centre, 2202D1 Tunney s Pasture, Ottawa, ON, Canada K1A 0L2
    Food Chem Toxicol 46:270-9. 2008
    ..In conclusion, these studies show that different lipid diets can alter the toxic effects of MeHg on male rat steroidogenesis in terms of serum testosterone and steroidogenic enzyme activities...
  91. ncbi An assessment of thimerosal use in childhood vaccines
    L K Ball
    Division of Vaccines and Related Products Applications, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Foodand Drug Administration, Rockville, Maryland 20852, USA
    Pediatrics 107:1147-54. 2001
    ..This action was prompted in part by a risk assessment from the Food and Drug Administration that is presented here...
  92. ncbi Methylmercury and the health of indigenous peoples: a risk management challenge for physical and social sciences and for public health policy
    B Wheatley
    Eco Anth Consulting, Kanata, Ontario, Canada
    Sci Total Environ 259:23-9. 2000
    ..An integrated approach such as this may help to limit adverse health effects in the indigenous communities affected...
  93. pmc Mercury methylation by dissimilatory iron-reducing bacteria
    E J Kerin
    University of Maryland, Chesapeake Biological Laboratory, Solomons, MD, USA
    Appl Environ Microbiol 72:7919-21. 2006
    ..Geobacter and Desulfuromonas are closely related to known Hg-methylating sulfate-reducing bacteria within the Deltaproteobacteria...
  94. ncbi Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain
    Masatake Fujimura
    Department of Basic Medical Sciences, National Institute for Minamata Disease, 4058 18 Hama, Minamata, Kumamoto 867 0008, Japan
    Neurotoxicology 30:1000-7. 2009
    ....
  95. ncbi Impact of iron amendment on net methylmercury export from tidal wetland microcosms
    Patrick D Ulrich
    Department of Civil and Environmental Engineering, University of California, Berkeley, California 94720 1710, USA
    Environ Sci Technol 44:7659-65. 2010
    ....
  96. ncbi Hydroelectric reservoir inundation (Rio Madeira Basin, Amazon) and changes in traditional lifestyle: impact on growth and neurodevelopment of pre-school children
    Rejane C Marques
    Escola de Enfermagem Anna Nery, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    Public Health Nutr 14:661-9. 2011
    ..To assess the dependence on fish consumption of families and its impact on nutritional status and neurodevelopment of pre-school children...
  97. ncbi Importance of sulfate reducing bacteria in mercury methylation and demethylation in periphyton from Bolivian Amazon region
    Darío Achá
    Environmental and Life Sciences Graduate Program, Department of Chemistry, Trent University, 1600 West Bank Drive, Peterborough, Ontario, Canada K9J 7B8
    Chemosphere 82:911-6. 2011
    ..This demonstrates the importance of community variability and complexity of microbial interactions for the overall methylmercury production in periphyton and their response to external stimulus...
  98. ncbi Comparative study of quercetin and its two glycoside derivatives quercitrin and rutin against methylmercury (MeHg)-induced ROS production in rat brain slices
    Caroline Wagner
    Centro de Ciencias Naturais e Exatas, Departamento de Quimica, Universidade Federal de Santa Maria, Santa Maria, RS 97105 900, Brazil
    Arch Toxicol 84:89-97. 2010
    ....
  99. pmc Transport of toxic metals by molecular mimicry
    Nazzareno Ballatori
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Environ Health Perspect 110:689-94. 2002
    ..Because other toxic metals also form complexes with endogenous molecules, comparable mechanisms may be involved in their membrane transport and disposition...
  100. ncbi Prenatal and early childhood exposure to mercury and methylmercury in Spain, a high-fish-consumer country
    Sergi Diez
    Environmental Chemistry Department, IDAEA CSIC, Barcelona, Spain
    Arch Environ Contam Toxicol 56:615-22. 2009
    ..Overall, we conclude that levels of mercury in Spain are among the highest in the non-exposed populations probably because of the relatively high fish consumption...
  101. ncbi Methanogens: principal methylators of mercury in lake periphyton
    Stéphanie Hamelin
    GEOTOP and Groupe de Recherche Interuniversitaire en Limnologie et en Environnement Aquatique GRIL, Université du Québec à Montréal, C P 8888, Succursale Centre Ville, Montréal, Québec, Canada
    Environ Sci Technol 45:7693-700. 2011
    ..This first clear demonstration of methanogens' role in mercury methylation in environmental periphyton samples expands the known diversity of microbial guilds that contribute to the formation of the neurotoxic substance methylmercury...

Research Grants43

  1. Conference on Intellectual Disability, Aging and Health
    PHILIP DAVIDSON; Fiscal Year: 2002
    ..This area will lead to a report of recommendations for the establishment of practice guidelines for medical care jointly issued by the AAMR and the AMA. ..
  2. Health Effects of Lifetime Exposure to Food Contaminants
    Philippe Grandjean; Fiscal Year: 2009
    ..The results may therefore provide new information that could very likely have an impact on the preventive efforts and standard-setting of the EPA and other regulatory agencies in the U.S and elsewhere. ..
  3. Effects of perinatal endocrine disrupters in children
    Philippe Grandjean; Fiscal Year: 2004
    ..Modern statistical methods will be used to determine whether these outcome variables are associated with estrogen, thyroid, or Ah receptor abnormalities and specific contaminant exposures prenatally or postnatally. ..
  4. Three-generation Human Study of Reproductive Effects of Marine Food Contaminants
    PHILIPPE ADAM GRANDJEAN; Fiscal Year: 2010
    ..Current evidence already suggests that these pathologies may already affect many populations, and the present proposal aims at identifying whether persistent organochlorine pollutants contribute to these abnormalities. ..
  5. MECHANISMS FOR RENAL UPTAKE OF MERCURY
    CHRISTY BRIDGES; Fiscal Year: 2005
    ..These studies are important in that they will determine the exact mechanisms that participate in the transport of mercury across the plasma membranes of the proximal tubular cells. ..
  6. Role of Multidrug Resistance Proteins 2 and/or 4, and DMPS and DMSA in the Renal
    CHRISTY BRIDGES; Fiscal Year: 2008
    ..These data will serve as the basis for the development of additional treatments for mercury poisoning. [unreadable] [unreadable] [unreadable] [unreadable]..
  7. MERCURY NEPHROTOXICITY AFTER A REDUCTION OF RENAL MASS
    RUDOLFS ZALUPS; Fiscal Year: 2002
    ..abstract_text> ..
  8. METALLOTHIONEIN, MERCURY AND MONOCYTE ACTIVATION
    RUDOLFS ZALUPS; Fiscal Year: 2006
    ....
  9. TRANSPORT AND TOXICITY OF MERCURY IN THE NEPHRON
    RUDOLFS ZALUPS; Fiscal Year: 2006
    ..to date, of the mechanisms involved in the uptake of inorganic mercuric ions along pars recta segments of the proximal tubule, which are the segments of the nephron most vulnerable to the nephrotoxic effects of mercury ..
  10. NEUROTOXICITY OF METHYLMERCURY ACROSS THE LIFESPAN
    M Newland; Fiscal Year: 2005
    ..Items 2-4 will be conducted as adults and 3-4 to 30 months of age. At death Hg and either Se or FA profiles will be determined, depending on the cohort. ..
  11. METHANOL EXPOSURE EFFECTS ON PRIMATE DEVELOPMENT
    THOMAS BURBACHER; Fiscal Year: 2001
    ....
  12. Maternal fatty acids, birth weight and child development
    Emily Oken; Fiscal Year: 2007
    ..abstract_text> ..
  13. Neurotoxic Interactions of Different Forms of Mercury
    Bernard Weiss; Fiscal Year: 2007
    ..The acquisition of these data offers a firm foundation for determining the risks to neurobehavioral development of concurrent exposures to both mercury species. ..
  14. Developmental Neurotoxicity of Phthalate Esters
    Bernard Weiss; Fiscal Year: 2008
    ..The proposed research will examine this question in rats, and translate its implications into human relevance. [unreadable] [unreadable] [unreadable]..
  15. DEVELOPMENTAL EFFECTS OF METHYLMERCURY
    THOMAS BURBACHER; Fiscal Year: 2002
    ..The proposed studies take full advantage of the history of these monkeys and represents the best possible use of this valuable resource. ..
  16. Fatty Acids and Cardiovascular Health
    Dariush Mozaffarian; Fiscal Year: 2007
    ..End of Abstract) [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  17. 9th International Neurotoxicology Assoc (INA9) Meeting
    Michael Aschner; Fiscal Year: 2003
    ....
  18. A LONGITUDINAL STUDY OF LEAD EXPOSURE AND DENTAL CARIES
    Gene Watson; Fiscal Year: 2003
    ..abstract_text> ..
  19. BAYESIAN BIOMARKER MODELS FOR CANCER GENETICS STUDIES
    SARAH THURSTON; Fiscal Year: 2004
    ..abstract_text> ..
  20. Neurotoxicity of Methylmercury in the Visual Cortex
    Yukun Yuan; Fiscal Year: 2007
    ..Results of this study will provide specific information about the selective neurotoxicity of MeHg in the visual system. [unreadable] [unreadable] [unreadable]..
  21. Potential Contribution of Environmental Metals to ALS
    WILLIAM ATCHISON; Fiscal Year: 2007
    ..possible contributor to motor neuron degeneration during ALS-particularly in susceptible or genetically predisposed populations. [unreadable] [unreadable] [unreadable]..
  22. PRENATAL PCB EXPOSURE AND COGNITIVE DEVELOPMENT
    Paul Stewart; Fiscal Year: 2010
    ..abstract_text> ..
  23. Low-Level Prenatal Lead Exposure and Retinal Toxicity
    Donald Fox; Fiscal Year: 2009
    ....
  24. Interdisciplinary Training: Neurodevelopmental Toxicology(RMI)
    David Bellinger; Fiscal Year: 2008
    ..Members of the faculty currently conduct a wealth of multidisciplinary research, which will provide trainees with ready opportunities to apply their training in ongoing research projects. [unreadable] [unreadable]..
  25. FUNCTIONS OF THE HEPATIC GAMMA-GLUTAMYL CYCLE
    Nazzareno Ballatori; Fiscal Year: 2007
    ....
  26. BIOSTATISTICAL TOPICS IN CARCINOGENICITY AND TERATOLOGY
    Louise Ryan; Fiscal Year: 2009
    ..3. To extend, evaluate and apply methods for assessing goodness-of-fit for correlated data and latent variable models via the use of Cholesky residuals. ..
  27. Murine Models of Presynaptic Neuromuscular Disease
    WILLIAM ATCHISON; Fiscal Year: 2009
    ..abstract_text> ..
  28. TREATMENT OF DEPRESSION IN ALZHEIMERS DISEASE
    Constantine Lyketsos; Fiscal Year: 2001
    ....
  29. CELL CYCLE REGULATION IN METAL DEVELOPMENTAL TOXICITY
    Elaine Faustman; Fiscal Year: 2002
    ....
  30. Regulation of GRP94: Targeting Novel Cancer Therapeutics
    Jeffrey Baker; Fiscal Year: 2004
    ..Together, the proposed analysis will lead to a greater understanding of GRP94 as a novel anti-cancer target. ..
  31. Therapy for self-injurious behavior in autism
    George Wagner; Fiscal Year: 2003
    ..In addition, based on this new model, the possible beneficial effects of risperidone, an antagonist of these transmitter systems, will be explored. ..
  32. NEUROBEHAVIORAL SEQUELAE OF CARDIAC SURGERY
    David Bellinger; Fiscal Year: 2005
    ..abstract_text> ..
  33. Neurobehavioral Development in Mercury-Exposed Zebrafish
    Daniel Weber; Fiscal Year: 2005
    ..exposure through continual yolk absorption of maternally-derived Hg. This study will mirror prospective studies on human populations over much shorter time periods. ..
  34. Cerebellar GABA-A as Targets of mercury Neurotoxicity
    WILLIAM ATCHISON; Fiscal Year: 2005
    ..effects of MeHg on cerebellar synaptic transmission, particularly inhibitory synaptic transmission, altered by knockout or mutation of genes for subunits such as the alpha6 or delta subunit which are unique to cerebellar granule cells?..
  35. METHYLMERCURY TRANSPORT ACROSS CELL MEMBRANES
    Nazzareno Ballatori; Fiscal Year: 2005
    ..Evaluate the molecular mechanism by which NAC stimulates renal excretion of MeHg. IV. Test the hypothesis that urinary excretion of MeHg following an NAC oral challenge may be used as a new biomarker of MeHg exposure. ..
  36. Methylmercury toxicity in neural development
    MATTHEW RAND; Fiscal Year: 2006
    ..This information will help direct strategies for prevention of MeHg toxicity, for example through pharmacologic administration of protease inhibitors. ..
  37. PRENATAL PCB EXPOSURE AND COGNITIVE DEVELOPMENT
    Paul Stewart; Fiscal Year: 2006
    ..In addition, school records for each child's New York State mandatory testing of English Language Arts and Math will be obtained for comparative analysis. ..
  38. Prenatal pesticide exposure in South Africa: CNS Effects
    Roberta White; Fiscal Year: 2005
    ..Collaboration between district health personnel, scientists at the University of Cape Town and the University of Natal in South Africa, and investigators at Boston University is key to the project. ..
  39. Depression in Alzheimer's Disease Study 2 (DIADS-2)
    Constantine Lyketsos; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  40. Mechanisms of Pb-induced Hypertension: Role of Altered Calcium Homeostasis
    WILLIAM ATCHISON; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  41. ALTERNATIVE MECHANISMS OF UGA CODON RECOGNITION
    Marla Berry; Fiscal Year: 2005
    ..Continuing studies of this process will surely unveil new and exciting information about the complex workings of the translation machinery. ..
  42. The Youth Employment Training Pilot Program
    Henry Anderson; Fiscal Year: 2002
    ..Data from the anonymous school based surveys will be used to determine whether youth who have obtained a work permit are less likely to experience a work related injury. ..
  43. SELENOPROTEIN P FUNCTION AND REGULATION OF EXPRESSION
    Marla Berry; Fiscal Year: 2007
    ..unreadable] [unreadable]..