methylmercury compounds

Summary

Summary: Organic compounds in which mercury is attached to a methyl group.

Top Publications

  1. ncbi The toxicology of mercury--current exposures and clinical manifestations
    Thomas W Clarkson
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    N Engl J Med 349:1731-7. 2003
  2. ncbi Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury
    P Grandjean
    Institute of Community Health, Odense University, Denmark
    Neurotoxicol Teratol 19:417-28. 1997
  3. pmc Methylmercury and brain development: imprecision and underestimation of developmental neurotoxicity in humans
    Philippe Grandjean
    Harvard School of Public Health, Boston, MA, USA
    Mt Sinai J Med 78:107-18. 2011
  4. pmc Balancing the benefits of n-3 polyunsaturated fatty acids and the risks of methylmercury exposure from fish consumption
    Kathryn R Mahaffey
    Department of Occupational and Environmental Health, George Washington University School of Public Health, Washington DC, USA
    Nutr Rev 69:493-508. 2011
  5. pmc Oxidative stress in MeHg-induced neurotoxicity
    Marcelo Farina
    Departamento de Bioquimica, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Florianopolis, SC, Brazil
    Toxicol Appl Pharmacol 256:405-17. 2011
  6. pmc Mercury exposure and risk of cardiovascular disease in two U.S. cohorts
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    N Engl J Med 364:1116-25. 2011
  7. ncbi Neurobehavioral effects of prenatal exposure to methylmercury and PCBs, and seafood intake: neonatal behavioral assessment scale results of Tohoku study of child development
    Keita Suzuki
    Environmental Health Sciences, Tohoku University, Graduate School of Medicine, 2 1 Seiryo machi, Sendai, Miyagi 980 8576, Japan Japan Society for the Promotion of Science, Tokyo, Japan
    Environ Res 110:699-704. 2010
  8. pmc Blood organic mercury and dietary mercury intake: National Health and Nutrition Examination Survey, 1999 and 2000
    Kathryn R Mahaffey
    Office of Science Coordination and Policy, Office of Prevention, Pesticides and Toxic Substances, U S Environmental Protection Agency, 1200 Pennsylvania Avenue, Washington, DC 20460, USA
    Environ Health Perspect 112:562-70. 2004
  9. ncbi Neurotoxicity and molecular effects of methylmercury
    A F Castoldi
    University of Pavia and Salvatore Maugeri Foundation, Pavia, Italy
    Brain Res Bull 55:197-203. 2001
  10. doi Ranking the contributions of commercial fish and shellfish varieties to mercury exposure in the United States: implications for risk communication
    Edward Groth
    Groth Consulting Services, 75 Clifford Avenue, Pelham, NY 10803 1702, USA
    Environ Res 110:226-36. 2010

Research Grants

  1. HEALTH HAZARDS OF METHYLMERCURY
    Thomas Clarkson; Fiscal Year: 1991
  2. Methyl Mercury Effects on Adolescent Development
    PHILIP DAVIDSON; Fiscal Year: 2007
  3. Methyl Mercury Effects on Adolescent Development
    PHILIP DAVIDSON; Fiscal Year: 2007
  4. Conference on Intellectual Disability, Aging and Health
    PHILIP DAVIDSON; Fiscal Year: 2002
  5. Methyl Mercury Effects on Adolescent Development
    PHILIP DAVIDSON; Fiscal Year: 2007
  6. Methyl Mercury Effects on Adolescent Development
    PHILIP DAVIDSON; Fiscal Year: 2008
  7. Autism in a Fish Eating Population
    PHILIP DAVIDSON; Fiscal Year: 2008
  8. Factors Modifying the Toxicity of Methylmercury in a Fish-Eating Population
    Philip W Davidson; Fiscal Year: 2011
  9. Methyl Mercury Effects on Adolescent Development
    PHILIP DAVIDSON; Fiscal Year: 2006
  10. Methyl Mercury Effects on Adolescent Development
    PHILIP DAVIDSON; Fiscal Year: 2006

Detail Information

Publications249 found, 100 shown here

  1. ncbi The toxicology of mercury--current exposures and clinical manifestations
    Thomas W Clarkson
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    N Engl J Med 349:1731-7. 2003
  2. ncbi Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury
    P Grandjean
    Institute of Community Health, Odense University, Denmark
    Neurotoxicol Teratol 19:417-28. 1997
    ..The effects on brain function associated with prenatal methylmercury exposure therefore appear widespread, and early dysfunction is detectable at exposure levels currently considered safe...
  3. pmc Methylmercury and brain development: imprecision and underestimation of developmental neurotoxicity in humans
    Philippe Grandjean
    Harvard School of Public Health, Boston, MA, USA
    Mt Sinai J Med 78:107-18. 2011
    ..The experience obtained with methylmercury should therefore be taken into account when evaluating the evidence for other substances suspected of being neurotoxic...
  4. pmc Balancing the benefits of n-3 polyunsaturated fatty acids and the risks of methylmercury exposure from fish consumption
    Kathryn R Mahaffey
    Department of Occupational and Environmental Health, George Washington University School of Public Health, Washington DC, USA
    Nutr Rev 69:493-508. 2011
    ..A framework for providing dietary advice for women of childbearing age on how to maximize the dietary intake of n-3 PUFAs while minimizing MeHg exposures is suggested...
  5. pmc Oxidative stress in MeHg-induced neurotoxicity
    Marcelo Farina
    Departamento de Bioquimica, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Florianopolis, SC, Brazil
    Toxicol Appl Pharmacol 256:405-17. 2011
    ....
  6. pmc Mercury exposure and risk of cardiovascular disease in two U.S. cohorts
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    N Engl J Med 364:1116-25. 2011
    ..Beneficial effects of the ingestion of fish and selenium may also modify such effects...
  7. ncbi Neurobehavioral effects of prenatal exposure to methylmercury and PCBs, and seafood intake: neonatal behavioral assessment scale results of Tohoku study of child development
    Keita Suzuki
    Environmental Health Sciences, Tohoku University, Graduate School of Medicine, 2 1 Seiryo machi, Sendai, Miyagi 980 8576, Japan Japan Society for the Promotion of Science, Tokyo, Japan
    Environ Res 110:699-704. 2010
    ..The neurobehavioral effect of prenatal exposure to PCBs remains unclear in our study. Further research is necessary to elucidate interactive effects of methylmercury, PCBs, and n-3 PUFAs, originating from fish, on child neurodevelopment...
  8. pmc Blood organic mercury and dietary mercury intake: National Health and Nutrition Examination Survey, 1999 and 2000
    Kathryn R Mahaffey
    Office of Science Coordination and Policy, Office of Prevention, Pesticides and Toxic Substances, U S Environmental Protection Agency, 1200 Pennsylvania Avenue, Washington, DC 20460, USA
    Environ Health Perspect 112:562-70. 2004
    ....
  9. ncbi Neurotoxicity and molecular effects of methylmercury
    A F Castoldi
    University of Pavia and Salvatore Maugeri Foundation, Pavia, Italy
    Brain Res Bull 55:197-203. 2001
    ..Here some examples of MeHg molecular effects occurring at low doses/concentrations are presented...
  10. doi Ranking the contributions of commercial fish and shellfish varieties to mercury exposure in the United States: implications for risk communication
    Edward Groth
    Groth Consulting Services, 75 Clifford Avenue, Pelham, NY 10803 1702, USA
    Environ Res 110:226-36. 2010
    ..I have sorted the 51 seafood varieties into six categories based on mercury levels, as a framework for improving risk communication in this regard...
  11. doi Methylmercury-induced neurotoxicity and apoptosis
    Sandra Ceccatelli
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Chem Biol Interact 188:301-8. 2010
    ..In this paper, we provide an overview of recent findings on methylmercury-induced neurotoxicity and cell death pathways that have been described in neural and endocrine cell systems...
  12. ncbi Adverse effects from environmental mercury loads on breeding common loons
    David C Evers
    BioDiversity Research Institute, 19 Flaggy Meadow Road, Gorham, ME 04038, USA
    Ecotoxicology 17:69-81. 2008
    ..Standardized monitoring programs are needed to determine if population sinks occur elsewhere and to track aquatic ecosystem responses to changes in Hg emissions and deposition...
  13. pmc Postnatal exposure to methyl mercury from fish consumption: a review and new data from the Seychelles Child Development Study
    Gary J Myers
    University of Rochester School of Medicine and Dentistry, Department of Neurology, Rochester, NY, United States
    Neurotoxicology 30:338-49. 2009
    ....
  14. ncbi Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity
    M Aschner
    Departments of Pediatrics and Pharmacology, Vanderbilt University Medical Center, B3307 Medical Center North, Nashville, TN 37232, USA
    Braz J Med Biol Res 40:285-91. 2007
    ....
  15. pmc Bioaccumulation syndrome: identifying factors that make some stream food webs prone to elevated mercury bioaccumulation
    Darren M Ward
    Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire, USA
    Ann N Y Acad Sci 1195:62-83. 2010
    ..Finally, based on an understanding of the ecological drivers of MeHg accumulation, we identify situations when anthropogenic effects and management practices could significantly exacerbate or ameliorate MeHg accumulation in stream fish...
  16. ncbi Dietary selenium's protective effects against methylmercury toxicity
    Nicholas V C Ralston
    Energy and Environmental Research Center, University of North Dakota, 15 North 23rd Street, Grand Forks, ND 58202, USA
    Toxicology 278:112-23. 2010
    ..Further studies of these relationships are needed to assist regulatory agencies in protecting and improving child health...
  17. pmc Evaluation of the cardiovascular effects of methylmercury exposures: current evidence supports development of a dose-response function for regulatory benefits analysis
    Henry A Roman
    Industrial Economics Inc, Cambridge, Massachusetts 02140, USA
    Environ Health Perspect 119:607-14. 2011
    ..A growing body of evidence suggests that MeHg exposure can also lead to increased risks of adverse cardiovascular impacts in exposed populations...
  18. ncbi Effects of 2,3-dimercapto-1-propanesulfonic acid (DMPS) on methylmercury-induced locomotor deficits and cerebellar toxicity in mice
    Márcia C Carvalho
    Departamento de Biologia Celular, Embriologia e Genetica, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Florianopolis, SC, Brazil
    Toxicology 239:195-203. 2007
    ..Histological analyses indicate that these phenomena are related to its capability of removing mercury from cerebellar cortex...
  19. doi Activation of TRPC cationic channels by mercurial compounds confers the cytotoxicity of mercury exposure
    Shang Zhong Xu
    Centre for Cardiovascular and Metabolic Research, Hull York Medical School, University of Hull, Hull, HU6 7RX, UK
    Toxicol Sci 125:56-68. 2012
    ..These results indicate that mercurial compounds are activators for TRPC5 and TRPC4 channels. Blockade of TRPC channels could be a novel strategy for preventing mercury-induced cytotoxicity and neurodevelopment impairment...
  20. doi The movement of aquatic mercury through terrestrial food webs
    Daniel A Cristol
    Institute for Integrative Bird Behavior Studies, Department of Biology, College of William and Mary, Williamsburg, VA 23185, USA
    Science 320:335. 2008
    ..Rivers contaminated with mercury may pose a threat to the many bird species that feed on predatory invertebrates in adjacent riparian habitats...
  21. pmc Genetic variation in glutathione-related genes and body burden of methylmercury
    Karin Schläwicke Engström
    Department of Occupational and Environmental Medicine, Lund University Hospital, Lund, Sweden
    Environ Health Perspect 116:734-9. 2008
    ..One possible explanation is hereditary differences in MeHg metabolism. MeHg is eliminated from the body as a glutathione (GSH) conjugate...
  22. ncbi Methylmercury exposure and health effects in humans: a worldwide concern
    Donna Mergler
    Department of Biological Sciences, Institute for Environmental Sciences, University of Quebec, Montreal, Canada
    Ambio 36:3-11. 2007
    ....
  23. pmc Synergistic neurotoxicity induced by methylmercury and quercetin in mice
    Roberta de P Martins
    Departamento de Bioquimica, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Campus Trindade, 88040 900 Florianopolis, SC, Brazil
    Food Chem Toxicol 47:645-9. 2009
    ..The present results indicate that under in vivo conditions quercetin and MeHg cause additive pro-oxidative effects toward the mice cerebellum and that such phenomenon is associated with the observed motor deficit...
  24. pmc Evidence on the human health effects of low-level methylmercury exposure
    Margaret R Karagas
    Section of Biostatistics and Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA
    Environ Health Perspect 120:799-806. 2012
    ..Despite its global relevance, synthesis of the available literature on low-level MeHg exposure has been limited...
  25. doi Sensitivity of dopaminergic neuron differentiation from stem cells to chronic low-dose methylmercury exposure
    Bastian Zimmer
    Doerenkamp Zbinden Chair of in vitro Toxicology and Biomedicine, Department of Biology, University of Konstanz, D 78457 Konstanz, Germany
    Toxicol Sci 121:357-67. 2011
    ..Thus, transcriptional profiling in differentiating mESC identified a subpopulation of neurons affected by MeHg, and a pharmacological intervention was identified that specifically protected these cells...
  26. pmc Sensitivity of continuous performance test (CPT) at age 14 years to developmental methylmercury exposure
    Jordi Julvez
    Harvard School of Public Health, Boston, MA, USA
    Neurotoxicol Teratol 32:627-32. 2010
    ..When using CPT data as a possible measure of neurotoxicity, test results should therefore be analyzed in regard to time from test initiation and not as overall average reaction times...
  27. ncbi Gene expression profiling in rat cerebellum following in utero and lactational exposure to mixtures of methylmercury, polychlorinated biphenyls and organochlorine pesticides
    B K Padhi
    Environment and Occupational Toxicology Division, HECSB, Health Canada, Tunney s Pasture, Ottawa, Ontario K1A 0L2, Canada
    Toxicol Lett 176:93-103. 2008
    ....
  28. ncbi Overview of modifiers of methylmercury neurotoxicity: chemicals, nutrients, and the social environment
    Deborah C Rice
    Maine Center for Disease Control and Prevention, Augusta, ME 04333, United States
    Neurotoxicology 29:761-6. 2008
    ..An understanding of the interactions of the multiple factors that determine the final behavioral outcome of exposure to methylmercury is crucial to risk assessment and risk management decisions...
  29. doi Intervention study on cardiac autonomic nervous effects of methylmercury from seafood
    Kozue Yaginuma-Sakurai
    Department of Environmental Health Sciences, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Sendai 980 8575, Japan
    Neurotoxicol Teratol 32:240-5. 2010
    ..Rather, long-term exposure to methylmercury may pose a potential risk for cardiac events involving sympathovagal imbalance among fish-consuming populations...
  30. pmc Methylmercury induces acute oxidative stress, altering Nrf2 protein level in primary microglial cells
    Mingwei Ni
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Toxicol Sci 116:590-603. 2010
    ..Taken together, our study has demonstrated that microglial cells are exquisitely sensitive to MeHg and respond rapidly to MeHg by upregulating the Nrf2-mediated antioxidant response...
  31. ncbi Effects of environmental methylmercury on the health of wild birds, mammals, and fish
    Anton M Scheuhammer
    National Wildlife Research Centre, Environment Canada, Carleton University, Ottawa
    Ambio 36:12-8. 2007
    ..Other piscivorous species may also benefit from decreased Hg exposure but have not been as extensively studied as the common loon...
  32. ncbi Mercury cycling in stream ecosystems. 3. Trophic dynamics and methylmercury bioaccumulation
    Lia C Chasar
    U S Geological Survey, Florida Integrated Science Center, 2639 North Monroe Street, Suite A 200, Tallahassee, Florida 32303, USA
    Environ Sci Technol 43:2733-9. 2009
    ....
  33. pmc Methylmercury exposure and adverse cardiovascular effects in Faroese whaling men
    Anna L Choi
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 117:367-72. 2009
    ..Methylmercury (MeHg), a worldwide contaminant found in fish and seafood, has been linked to an increased risk of cardiovascular mortality...
  34. pmc Algal blooms reduce the uptake of toxic methylmercury in freshwater food webs
    Paul C Pickhardt
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 99:4419-23. 2002
    ..Bloom dilution may provide a mechanistic explanation for lower CH3Hg+ accumulation by zooplankton and fish in algal-rich relative to algal-poor systems...
  35. ncbi A quantitative risk-benefit analysis of changes in population fish consumption
    Joshua T Cohen
    Harvard Center for Risk Analysis, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Prev Med 29:325-34. 2005
    ....
  36. doi Changes in mercury bioaccumulation in an apex predator in response to removal of an introduced competitor
    Jesse M Lepak
    Warner College of Natural Resources, Colorado Cooperative Fish and Wildlife Research Unit, Colorado State University, Fort Collins, CO 80523, USA
    Ecotoxicology 18:488-98. 2009
    ..These data provide evidence for a mechanism (diet shift due to reduced competition) by which changes in food web structure can influence MeHg concentrations in top predators...
  37. ncbi Mercury cycling in stream ecosystems. 2. Benthic methylmercury production and bed sediment-pore water partitioning
    Mark Marvin-DiPasquale
    U S Geological Survey, 345 Middlefield Road, Menlo Park, California 94025, USA
    Environ Sci Technol 43:2726-32. 2009
    ....
  38. pmc Response inhibition and error monitoring during a visual go/no-go task in inuit children exposed to lead, polychlorinated biphenyls, and methylmercury
    Olivier Boucher
    Centre de Recherche du Centre Hospitalier Universitaire de Québec, Quebec, Canada
    Environ Health Perspect 120:608-15. 2012
    ..Lead (Pb) and polychlorinated biphenyls (PCBs) are neurotoxic contaminants that have been related to impairment in response inhibition...
  39. ncbi Sensitivity of immature neurons in culture to metal-induced changes in reactive oxygen species and intracellular free calcium
    W R Mundy
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Neurotoxicology 21:1135-44. 2000
    ..These results suggest that there may be inherent differences in the sensitivity of neurons to toxicant-induced increases in ROS and [Ca2+] depending upon age and cell type...
  40. pmc Fetal and maternal immune responses to methylmercury exposure: a cross-sectional study
    Jennifer F Nyland
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615N Wolfe Street, Baltimore, MD 21205, USA
    Environ Res 111:584-9. 2011
    ..However, unlike previous data from adult males and non-pregnant females, we found no evidence that antinuclear and antinucleolar autoantibody titer is a reliable biomarker of mercury immunotoxicity in this population...
  41. ncbi The effects of methylmercury on mitochondrial function and reactive oxygen species formation in rat striatal synaptosomes are age-dependent
    Anne Dreiem
    New York State Department of Health, Wadsworth Center, Albany, New York, 12201, USA
    Toxicol Sci 87:156-62. 2005
    ..These age-dependent differences in susceptibility to MeHg are most likely due to a less efficient ROS detoxifying system and lower activity of mitochondrial enzymes in tissue from young animals...
  42. ncbi Methylmercury alters glutamate transport in astrocytes
    M Aschner
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Neurochem Int 37:199-206. 2000
    ..This manuscript details the role of astrocytes in mediating MeHg-induced excitotoxicity, and elaborates on the protective role afforded by metallothioneins (MTs) in attenuating MeHg cytotoxicity...
  43. doi Awake at the switch: improving fish consumption advisories for at-risk women
    Mario F Teisl
    School of Economics, University of Maine, Orono, ME 04469, USA
    Sci Total Environ 409:3257-66. 2011
    ..We conclude a well-designed advisory can successfully transform a complex risk/benefit message into one that leads to appropriate knowledge and behavioral changes...
  44. ncbi Attenuated growth of breast-fed children exposed to increased concentrations of methylmercury and polychlorinated biphenyls
    Philippe Grandjean
    Department of Environmental Health, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, USA
    FASEB J 17:699-701. 2003
    ..Thus, in communities with increased contaminant exposures, risks associated with lactational transfer of toxicants to the infant must be considered when judging the benefits of prolonged breast-feeding...
  45. ncbi Disruption of intraneuronal divalent cation regulation by methylmercury: are specific targets involved in altered neuronal development and cytotoxicity in methylmercury poisoning?
    Tobi L Limke
    Department of Pharmacology and Toxicology, Institute for Environmental Toxicology, Michigan State University, B 331 Life Sciences Building, East Lansing, MI 48824 1317, USA
    Neurotoxicology 25:741-60. 2004
    ..In this review, we examine the hypothesis that MeHg affects specific targets to cause disruption of neuronal development and cell death...
  46. doi Human developmental neurotoxicity of methylmercury: impact of variables and risk modifiers
    Anna F Castoldi
    Toxicology Division, University of Pavia, Via Palestro 26, 27100 Pavia, Italy
    Regul Toxicol Pharmacol 51:201-14. 2008
    ..These factors, together with the notion that some symptoms may ensue or exacerbate with aging, contribute to the difficulties in the definition of safe levels for developmental exposure...
  47. doi Deleterious effects in mice of fish-associated methylmercury contained in a diet mimicking the Western populations' average fish consumption
    Jean Paul Bourdineaud
    Bordeaux University CNRS, UMR EPOC 5805, Arcachon Marine Station, Place du Docteur Peyneau, Arcachon, 33120, France
    Environ Int 37:303-13. 2011
    ....
  48. ncbi Acute exposure to methylmercury opens the mitochondrial permeability transition pore in rat cerebellar granule cells
    Tobi L Limke
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Appl Pharmacol 178:52-61. 2002
    ..2-0.5 microM), but not at higher MeHg concentrations (1.0-2.0 microM). Thus, the MTP appears to play a significant role in the cellular effects following acute exposure of cerebellar granule neurons to MeHg...
  49. ncbi An assessment of thimerosal use in childhood vaccines
    L K Ball
    Division of Vaccines and Related Products Applications, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Foodand Drug Administration, Rockville, Maryland 20852, USA
    Pediatrics 107:1147-54. 2001
    ..This action was prompted in part by a risk assessment from the Food and Drug Administration that is presented here...
  50. doi Impact of iron amendment on net methylmercury export from tidal wetland microcosms
    Patrick D Ulrich
    Department of Civil and Environmental Engineering, University of California, Berkeley, California 94720 1710, USA
    Environ Sci Technol 44:7659-65. 2010
    ....
  51. pmc Mercury methylation by dissimilatory iron-reducing bacteria
    E J Kerin
    University of Maryland, Chesapeake Biological Laboratory, Solomons, MD, USA
    Appl Environ Microbiol 72:7919-21. 2006
    ..Geobacter and Desulfuromonas are closely related to known Hg-methylating sulfate-reducing bacteria within the Deltaproteobacteria...
  52. doi Comparative study of quercetin and its two glycoside derivatives quercitrin and rutin against methylmercury (MeHg)-induced ROS production in rat brain slices
    Caroline Wagner
    Centro de Ciencias Naturais e Exatas, Departamento de Quimica, Universidade Federal de Santa Maria, Santa Maria, RS 97105 900, Brazil
    Arch Toxicol 84:89-97. 2010
    ....
  53. pmc Transport of toxic metals by molecular mimicry
    Nazzareno Ballatori
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Environ Health Perspect 110:689-94. 2002
    ..Because other toxic metals also form complexes with endogenous molecules, comparable mechanisms may be involved in their membrane transport and disposition...
  54. ncbi Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain
    Masatake Fujimura
    Department of Basic Medical Sciences, National Institute for Minamata Disease, 4058 18 Hama, Minamata, Kumamoto 867 0008, Japan
    Neurotoxicology 30:1000-7. 2009
    ....
  55. pmc Total imprecision of exposure biomarkers: implications for calculating exposure limits
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Am J Ind Med 50:712-9. 2007
    ..Unrecognized imprecision leads to underestimation of the true toxicity of the exposure. We have assessed the total imprecision of exposure biomarkers and the implications for calculation of exposure limits...
  56. doi Prenatal and early childhood exposure to mercury and methylmercury in Spain, a high-fish-consumer country
    Sergi Diez
    Environmental Chemistry Department, IDAEA CSIC, Barcelona, Spain
    Arch Environ Contam Toxicol 56:615-22. 2009
    ..Overall, we conclude that levels of mercury in Spain are among the highest in the non-exposed populations probably because of the relatively high fish consumption...
  57. ncbi Deposition and cycling of sulfur controls mercury accumulation in Isle Royale fish
    Paul E Drevnick
    Department of Zoology, Miami University, Oxford, Ohio 45056, USA
    Environ Sci Technol 41:7266-72. 2007
    ..Therefore, reductions in anthropogenic sulfur emissions may provide a synergistic solution to the mercury problem in sulfate-limited freshwaters...
  58. ncbi An investigation of the effects of methylmercury in rats fed different dietary fats and proteins: testicular steroidogenic enzymes and serum testosterone levels
    Mark J McVey
    Toxicology Research Division, Health Products and Foods Branch, Food Directorate, Health Canada, Sir Fredrick G Banting Research Centre, 2202D1 Tunney s Pasture, Ottawa, ON, Canada K1A 0L2
    Food Chem Toxicol 46:270-9. 2008
    ..In conclusion, these studies show that different lipid diets can alter the toxic effects of MeHg on male rat steroidogenesis in terms of serum testosterone and steroidogenic enzyme activities...
  59. ncbi Changes in mercury concentrations of segmental maternal hair during gestation and their correlations with other biomarkers of fetal exposure to methylmercury in the Japanese population
    Mineshi Sakamoto
    Department of Epidemiology, National Institute for Minamata Disease, Kumamoto 867 0008, Japan
    Environ Res 106:270-6. 2008
    ..In addition, the segmental maternal hair throughout gestation is essential to obtain important information on MeHg exposure during the different sensitive windows or bolus MeHg exposure during gestation...
  60. pmc Mercury methylation from unexpected sources: molybdate-inhibited freshwater sediments and an iron-reducing bacterium
    Emily J Fleming
    Section of Microbiology, 357 Briggs Hall, University of California, Davis, CA 95616, USA
    Appl Environ Microbiol 72:457-64. 2006
    ..We suggest that mercury methylation by iron-reducing bacteria represents a previously unidentified and potentially significant source of this environmental toxin in iron-rich freshwater sediments...
  61. doi Hydroelectric reservoir inundation (Rio Madeira Basin, Amazon) and changes in traditional lifestyle: impact on growth and neurodevelopment of pre-school children
    Rejane C Marques
    Escola de Enfermagem Anna Nery, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    Public Health Nutr 14:661-9. 2011
    ..To assess the dependence on fish consumption of families and its impact on nutritional status and neurodevelopment of pre-school children...
  62. doi Importance of sulfate reducing bacteria in mercury methylation and demethylation in periphyton from Bolivian Amazon region
    Darío Achá
    Environmental and Life Sciences Graduate Program, Department of Chemistry, Trent University, 1600 West Bank Drive, Peterborough, Ontario, Canada K9J 7B8
    Chemosphere 82:911-6. 2011
    ..This demonstrates the importance of community variability and complexity of microbial interactions for the overall methylmercury production in periphyton and their response to external stimulus...
  63. ncbi Protective effects of organoselenium compounds against methylmercury-induced oxidative stress in mouse brain mitochondrial-enriched fractions
    D F Meinerz
    Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil
    Braz J Med Biol Res 44:1156-63. 2011
    ....
  64. ncbi Methylmercury and the health of indigenous peoples: a risk management challenge for physical and social sciences and for public health policy
    B Wheatley
    Eco Anth Consulting, Kanata, Ontario, Canada
    Sci Total Environ 259:23-9. 2000
    ..An integrated approach such as this may help to limit adverse health effects in the indigenous communities affected...
  65. doi Methanogens: principal methylators of mercury in lake periphyton
    Stéphanie Hamelin
    GEOTOP and Groupe de Recherche Interuniversitaire en Limnologie et en Environnement Aquatique GRIL, Université du Québec à Montréal, C P 8888, Succursale Centre Ville, Montréal, Québec, Canada
    Environ Sci Technol 45:7693-700. 2011
    ..This first clear demonstration of methanogens' role in mercury methylation in environmental periphyton samples expands the known diversity of microbial guilds that contribute to the formation of the neurotoxic substance methylmercury...
  66. ncbi A toxicokinetic model for predicting the tissue distribution and elimination of organic and inorganic mercury following exposure to methyl mercury in animals and humans. II. Application and validation of the model in humans
    G Carrier
    Chair in Toxicological Risk Assessment for Human Health, Department of Environmental and Occupational Health, Faculty of Medicine, Universite de Montreal, Main Station, Montreal, Quebec, H3C 3J7, Canada
    Toxicol Appl Pharmacol 171:50-60. 2001
    ..Thus, accessible measurements on these matrices allow inferences of past, present, and future burdens. This could prove to be a useful tool in assessing the health risks associated with various circumstances of methyl mercury exposure...
  67. ncbi Distribution patterns of mercury in lakes and rivers of northeastern North America
    Ian F Dennis
    Environment Canada, Atlantic Region, PO Box 6227, Sackville NB E4L 1G6, Canada
    Ecotoxicology 14:113-23. 2005
    ....
  68. doi Docosahexaenoic acid may act as a neuroprotector for methylmercury-induced neurotoxicity in primary neural cell cultures
    Parvinder Kaur
    Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology, Olav Kyrresgt 3, N 7489 Trondheim, Norway
    Neurotoxicology 29:978-87. 2008
    ....
  69. ncbi Methylmercury cytotoxicity in PC12 cells is mediated by primary glutathione depletion independent of excess reactive oxygen species generation
    Rita Gatti
    Department of Experimental Medicine, Via Volturno 39, Universita degli Studi di Parma, 43100 Parma, Italy
    Toxicology 204:175-85. 2004
    ..These results provide experimental evidence that, in this cell model, MeHgOH triggers cell death via a primary depletion of GSH but in the absence of ROS overproduction...
  70. pmc Adverse effects of methylmercury: environmental health research implications
    Philippe Grandjean
    Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark
    Environ Health Perspect 118:1137-45. 2010
    ....
  71. ncbi Low level and sub-chronic exposure to methylmercury induces hypertension in rats: nitric oxide depletion and oxidative damage as possible mechanisms
    Denise Grotto
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP 14040 903, Brazil
    Arch Toxicol 83:653-62. 2009
    ....
  72. doi Methylmercury speciation influences brain gene expression and behavior in gestationally-exposed mice pups
    Chris N Glover
    National Institute of Nutrition and Seafood Research, 5817 Bergen, Norway
    Toxicol Sci 110:389-400. 2009
    ..The results show differences between the toxic impacts of MeHg species, and also highlight the potential utility of an integrated approach incorporating gene expression with behavioral endpoints...
  73. pmc Quantitative approach for incorporating methylmercury risks and omega-3 fatty acid benefits in developing species-specific fish consumption advice
    Gary L Ginsberg
    Connecticut Department of Public Health, Hartford, Connecticut 06134, USA
    Environ Health Perspect 117:267-75. 2009
    ..One approach is to provide advice for individual species that highlights beneficial fish while cautioning against riskier fish...
  74. ncbi Role of docosahexaenoic acid in modulating methylmercury-induced neurotoxicity
    Parvinder Kaur
    Department of Neuroscience, Norwegian University of Science and Technology, N 7489, Trondheim, Norway
    Toxicol Sci 100:423-32. 2007
    ..These findings provide experimental evidence that although pretreatment with DHA reduces cell-associated MeHg, it causes an increased ROS (p < 0.001) and GSH depletion (p < 0.05) in C6 cells...
  75. ncbi Wetland influence on mercury fate and transport in a temperate forested watershed
    Pranesh Selvendiran
    Department of Civil and Environmental Engineering, Syracuse University, Syracuse, NY 13244, USA
    Environ Pollut 154:46-55. 2008
    ..The annual fluxes of THg and MeHg at the outlet of the watershed were 2.3 and 0.092microg/m2-year respectively...
  76. pmc Selenium as a potential protective factor against mercury developmental neurotoxicity
    Anna L Choi
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Environ Res 107:45-52. 2008
    ..Additional research is needed to determine the identity of the nutrients responsible for the beneficial effects...
  77. ncbi The in vitro effects of selenomethionine on methylmercury-induced neurotoxicity
    Parvinder Kaur
    Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology, Olav Kyrresgt 3, N 7489 Trondheim, Norway
    Toxicol In Vitro 23:378-85. 2009
    ..These findings provide experimental evidence that preincubation with SeMet increases Se content in cells and prevents against increased MeHg-induced ROS generation...
  78. ncbi Modification of mercury toxicity by selenium: practical importance?
    Chiho Watanabe
    Department of Human Ecology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Tohoku J Exp Med 196:71-7. 2002
    ..Compared to the experimental findings, little evidence of the toxicological modification of MeHg by selenium was obtained in epidemiological studies...
  79. pmc Does prenatal methylmercury exposure from fish consumption affect blood pressure in childhood?
    Sally W Thurston
    Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, United States
    Neurotoxicology 28:924-30. 2007
    ..We examined this relationship in the Seychelles Islands to determine if it was present in a society exposed primarily to MeHg from consuming ocean fish...
  80. ncbi Dietary and tissue selenium in relation to methylmercury toxicity
    Nicholas V C Ralston
    Energy and Environmental Research Center, University of North Dakota, Grand Forks, ND 58202, United States
    Neurotoxicology 29:802-11. 2008
    ..Therefore, selenoenzymes may be the molecular target of methylmercury toxicity...
  81. ncbi Permanent waving does not change mercury concentration in the proximal segment of hair close to scalp
    Takashi Ohba
    Environmental Health Sciences, Tohoku University Graduate School of Medicine, Sendai, Japan
    Tohoku J Exp Med 214:69-78. 2008
    ..Therefore, mercury concentrations in the proximal segment of maternal hair collected in the right time can be a good biomarker of fetal methylmercury exposure...
  82. pmc Effects of gestational exposure to methylmercury and dietary selenium on reinforcement efficacy in adulthood
    Miranda N Reed
    Department of Neurology and Neuroscience, University of Minnesota Medical School, 420 Delaware St, Minneapolis, MN 55455, USA
    Neurotoxicol Teratol 30:29-37. 2008
    ..6 ppm Se, 5 ppm Hg group. This extends an earlier observation that developmental MeHg exposure enhances reinforcer efficacy, an effect that could be related to reports of perseveration...
  83. pmc Negative confounding in the evaluation of toxicity: the case of methylmercury in fish and seafood
    Anna L Choi
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    Crit Rev Toxicol 38:877-93. 2008
    ..Attention should also be paid to the occurrence of negative confounding in other connections...
  84. doi Wetland influences on mercury transport and bioaccumulation in South Carolina
    Jane L Guentzel
    Coastal Carolina University, Department of Marine Science, P O Box 261954 Conway, SC 29528 6054, USA
    Sci Total Environ 407:1344-53. 2009
    ..66; P=0.003). This correlation explains 66% of the variance in the data and suggests that increasing percentages of wetland area contribute to fish Hg concentrations in SC coastal plain rivers...
  85. ncbi Exploring nonlinear association between prenatal methylmercury exposure from fish consumption and child development: evaluation of the Seychelles Child Development Study nine-year data using semiparametric additive models
    Li Shan Huang
    Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Environ Res 97:100-8. 2005
    ..We conclude that this reanalysis supports the primary linear analysis, showing little evidence for a prenatal adverse effect...
  86. ncbi Toxicological effects of in utero and lactational exposure of rats to a mixture of environmental contaminants detected in Canadian Arctic human populations
    Ih Chu
    Environmental and Occupational Toxicology Division, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada
    J Toxicol Environ Health A 71:93-108. 2008
    ..05-mg/kg group, which is comparable to that found in humans living in the Canadian Arctic region...
  87. ncbi Influence of natural dissolved organic carbon on the bioavailability of mercury to a freshwater alga
    P R Gorski
    Limnology and Marine Sciences Program, University of Wisconsin Madison, Madison, WI, USA
    Environ Pollut 154:116-23. 2008
    ..However, variability of BCFs at low DOC indicates that DOC composition or other ligands may determine site-specific bioavailability of Hg...
  88. ncbi Wetlands as principal zones of methylmercury production in southern Louisiana and the Gulf of Mexico region
    B D Hall
    Environmental Chemistry and Technology Program, University of Wisconsin Madison, Madison, WI 53706, USA
    Environ Pollut 154:124-34. 2008
    ....
  89. pmc Methylmercury toxicity and Nrf2-dependent detoxification in astrocytes
    Ling Wang
    Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Toxicol Sci 107:135-43. 2009
    ..Modulation of Nrf2 by pharmacological modalities should afford a treatment to attenuate MeHg-induced neurotoxicity...
  90. ncbi Cytoprotective role of Nrf2/Keap1 system in methylmercury toxicity
    Takashi Toyama
    Master s Program in Environmental Sciences, University of Tsukuba, 1 1 1, Tennodai, Tsukuba, Ibaraki 305 8572, Japan
    Biochem Biophys Res Commun 363:645-50. 2007
    ..Our findings indicate that MeHg activates Nrf2 and the activation of Nrf2 is essential for reduction of MeHg toxicity by facilitating its excretion into extracellular space...
  91. pmc Accelerated methylmercury elimination in gamma-glutamyl transpeptidase-deficient mice
    N Ballatori
    Department of Environmental Medicine, University of Rochester School of Medicine, New York 14642, USA
    Am J Pathol 152:1049-55. 1998
    ....
  92. ncbi Mercury sequestration in forests and peatlands: a review
    D F Grigal
    Department of Soil, Water, and Climate, 439 Borlaug Hall, 1991 Upper Buford Circle, Univ of Minnesota, St Paul, MN 55108, USA
    J Environ Qual 32:393-405. 2003
    ..If global climate change affects C storage it will indirectly affect Hg storage, having a major effect on the balance between emissions and sequestration and on the global Hg cycle...
  93. ncbi Reduction of arginase I activity and manganese levels in the liver during exposure of rats to methylmercury: a possible mechanism
    Hironori Kanda
    Master s Program in Environmental Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Arch Toxicol 82:803-8. 2008
    ..These results suggest that MeHg-mediated suppression of hepatic arginase I activity in vivo is, at least in part, attributable to covalent modification of MeHg or substantial leakage of Mn ions from the active site...
  94. ncbi Effects of methylmercury on the microvasculature of the developing brain
    M Bertossi
    Dipartimento di Scienze Biomediche, Facolta di Medicina e Chirurgia, Universita di Foggia, Via L Pinto, 71100 Foggia, Italy
    Neurotoxicology 25:849-57. 2004
    ....
  95. ncbi Postimpoundment time course of increased mercury concentrations in fish in hydroelectric reservoirs of northern Manitoba, Canada
    R A Drew Bodaly
    Fisheries and Oceans Canada, Central and Arctic Region, Freshwater Institute, 501 University Crescent, R3T 2N6, Winnipeg, Canada
    Arch Environ Contam Toxicol 53:379-89. 2007
    ..Downstream effects were apparent because many reservoirs downstream of other impoundments had higher Hg concentrations in fish than would be expected on the basis of flooding amount...
  96. ncbi Seasonal mercury exposure and oxidant-antioxidant status of James Bay sport fishermen
    Marie Claire Bélanger
    Québec Lipid Research Centre, CHUL Research Centre, Centre Hospitalier Universitaire de Quebec, Quebec City, Quebec, Canada G1V 4G2
    Metabolism 57:630-6. 2008
    ..The beneficial effects of seasonal fishing activity and fish consumption on cardiovascular health may suppress detrimental effects of concomitant moderate methylmercury exposure...
  97. ncbi Relationship between wetlands and mercury in brook trout
    Mark S Castro
    Appalachian Laboratory, University of Maryland Center for Environmental Science, Frostburg, MD 21532, USA
    Arch Environ Contam Toxicol 52:97-103. 2007
    ..The relatively low methylmercury concentrations in the Upper Savage River may be caused by a mercury concentration gradient downstream of the wetland...
  98. doi Mercury bioaccumulation and trophic transfer in the terrestrial food web of a montane forest
    Christopher C Rimmer
    Vermont Center for Ecostudies, P O Box 420, Norwich, VT 05055, USA
    Ecotoxicology 19:697-709. 2010
    ....
  99. doi Gene expression profiles in the brain of the neonate mouse perinatally exposed to methylmercury and/or polychlorinated biphenyls
    Miyuki Shimada
    Department of Environmental Health Sciences, Tohoku University Graduate School of Medicine, 2 1 Seiryomachi, Aoba ku, Sendai 980 8575, Japan
    Arch Toxicol 84:271-86. 2010
    ..These results suggest that co-exposure does not simply exacerbate the toxicity of MeHg alone or PCB alone, but stimulates a protection system...
  100. ncbi Health and environmental assessment of mercury exposure in a gold mining community in Western Mindanao, Philippines
    Nelia Cortes-Maramba
    National Poison Control and Information Service, College of Medicine, University of the Philippines Manila, Philippines
    J Environ Manage 81:126-34. 2006
    ..09). An interesting finding in this study was the increasing incidence of elevated diastolic blood pressure with elevated hair total mercury levels (p=0.07). Mercury storage at home is a risk factor...
  101. ncbi Assessment of methylmercury exposure in Wisconsin
    Lynda Knobeloch
    Wisconsin Department of Health and Family Services, 1 W Wilson St, Rm 150, Madison, WI 53703, USA
    Environ Res 103:205-10. 2007
    ..These findings suggest that exposure to MeHg is widespread and that men may be a previously unrecognized high risk population...

Research Grants110 found, 100 shown here

  1. HEALTH HAZARDS OF METHYLMERCURY
    Thomas Clarkson; Fiscal Year: 1991
    The overall objective is to more clearly define human health risks from prenatal exposure to methylmercury compounds (MeHg)...
  2. Methyl Mercury Effects on Adolescent Development
    PHILIP DAVIDSON; Fiscal Year: 2007
    ..abstract_text> ..
  3. Methyl Mercury Effects on Adolescent Development
    PHILIP DAVIDSON; Fiscal Year: 2007
    ..abstract_text> ..
  4. Conference on Intellectual Disability, Aging and Health
    PHILIP DAVIDSON; Fiscal Year: 2002
    ..This area will lead to a report of recommendations for the establishment of practice guidelines for medical care jointly issued by the AAMR and the AMA. ..
  5. Methyl Mercury Effects on Adolescent Development
    PHILIP DAVIDSON; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  6. Methyl Mercury Effects on Adolescent Development
    PHILIP DAVIDSON; Fiscal Year: 2008
    ..abstract_text> ..
  7. Autism in a Fish Eating Population
    PHILIP DAVIDSON; Fiscal Year: 2008
    ..The Seychelles Child Development Study provides a rare opportunity to test the hypothesis that there is an association between ASD and methylmercury exposure from fish consumption. ..
  8. Factors Modifying the Toxicity of Methylmercury in a Fish-Eating Population
    Philip W Davidson; Fiscal Year: 2011
    ..The results should have immediate and important public health implications not only for agencies that advise the public about fish consumption, but also for public health policies regarding nutrient intake during pregnancy. ..
  9. Methyl Mercury Effects on Adolescent Development
    PHILIP DAVIDSON; Fiscal Year: 2006
    ..abstract_text> ..
  10. Methyl Mercury Effects on Adolescent Development
    PHILIP DAVIDSON; Fiscal Year: 2006
    ..abstract_text> ..
  11. Methyl Mercury Effects on Adolescent Development
    PHILIP DAVIDSON; Fiscal Year: 2009
    ..abstract_text> ..
  12. Factors Modifying the Toxicity of Methylmercury in a Fish-Eating Population
    Philip W Davidson; Fiscal Year: 2010
    ..The results should have immediate and important public health implications not only for agencies that advise the public about fish consumption, but also for public health policies regarding nutrient intake during pregnancy. ..
  13. Methyl Mercury Effects on Adolescent Development
    PHILIP DAVIDSON; Fiscal Year: 2009
    ..abstract_text> ..
  14. Methyl Mercury Effects on Adolescent Development
    PHILIP DAVIDSON; Fiscal Year: 2005
    ..abstract_text> ..
  15. Methyl Mercury Effect on Adolescent Development Renewal
    Philip W Davidson; Fiscal Year: 2010
    ....
  16. Role of Multidrug Resistance Proteins 2 and/or 4, and DMPS and DMSA in the Renal
    CHRISTY BRIDGES; Fiscal Year: 2008
    ..These data will serve as the basis for the development of additional treatments for mercury poisoning. [unreadable] [unreadable] [unreadable] [unreadable]..
  17. MECHANISMS FOR RENAL UPTAKE OF MERCURY
    CHRISTY BRIDGES; Fiscal Year: 2005
    ..These studies are important in that they will determine the exact mechanisms that participate in the transport of mercury across the plasma membranes of the proximal tubular cells. ..
  18. Role of Multidrug Resistance Proteins 2 and/or 4, and DMPS and DMSA in the Renal
    CHRISTY BRIDGES; Fiscal Year: 2007
    ..These data will serve as the basis for the development of additional treatments for mercury poisoning. [unreadable] [unreadable] [unreadable] [unreadable]..
  19. METALLOTHIONEIN, MERCURY AND MONOCYTE ACTIVATION
    RUDOLFS ZALUPS; Fiscal Year: 2002
    ....
  20. TRANSPORT AND TOXICITY OF MERCURY IN THE NEPHRON
    RUDOLFS ZALUPS; Fiscal Year: 2004
    ..to date, of the mechanisms involved in the uptake of inorganic mercuric ions along pars recta segments of the proximal tubule, which are the segments of the nephron most vulnerable to the nephrotoxic effects of mercury ..
  21. TRANSPORT AND TOXICITY OF MERCURY IN THE NEPHRON
    RUDOLFS ZALUPS; Fiscal Year: 2002
    ..to date, of the mechanisms involved in the uptake of inorganic mercuric ions along pars recta segments of the proximal tubule, which are the segments of the nephron most vulnerable to the nephrotoxic effects of mercury ..
  22. MERCURY NEPHROTOXICITY AFTER A REDUCTION OF RENAL MASS
    RUDOLFS ZALUPS; Fiscal Year: 2002
    ..abstract_text> ..
  23. TRANSPORT AND TOXICITY OF MERCURY IN THE NEPHRON
    RUDOLFS ZALUPS; Fiscal Year: 2002
    ..to date, of the mechanisms involved in the uptake of inorganic mercuric ions along pars recta segments of the proximal tubule, which are the segments of the nephron most vulnerable to the nephrotoxic effects of mercury ..
  24. METALLOTHIONEIN, MERCURY AND MONOCYTE ACTIVATION
    RUDOLFS ZALUPS; Fiscal Year: 2006
    ....
  25. METALLOTHIONEIN, MERCURY AND MONOCYTE ACTIVATION
    RUDOLFS ZALUPS; Fiscal Year: 2003
    ....
  26. METALLOTHIONEIN, MERCURY AND MONOCYTE ACTIVATION
    RUDOLFS ZALUPS; Fiscal Year: 2004
    ....
  27. TRANSPORT AND TOXICITY OF MERCURY IN THE NEPHRON
    RUDOLFS ZALUPS; Fiscal Year: 2003
    ..to date, of the mechanisms involved in the uptake of inorganic mercuric ions along pars recta segments of the proximal tubule, which are the segments of the nephron most vulnerable to the nephrotoxic effects of mercury ..
  28. MERCURY NEPHROTOXICITY AFTER A REDUCTION OF RENAL MASS
    RUDOLFS ZALUPS; Fiscal Year: 2001
    ..abstract_text> ..
  29. TRANSPORT AND TOXICITY OF MERCURY IN THE NEPHRON
    RUDOLFS ZALUPS; Fiscal Year: 1999
    ....
  30. METALLOTHIONEIN, MERCURY AND MONOCYTE ACTIVATION
    RUDOLFS ZALUPS; Fiscal Year: 2005
    ....
  31. TRANSPORT AND TOXICITY OF MERCURY IN THE NEPHRON
    RUDOLFS ZALUPS; Fiscal Year: 1999
    ....
  32. TRANSPORT AND TOXICITY OF MERCURY IN THE NEPHRON
    RUDOLFS ZALUPS; Fiscal Year: 2005
    ..to date, of the mechanisms involved in the uptake of inorganic mercuric ions along pars recta segments of the proximal tubule, which are the segments of the nephron most vulnerable to the nephrotoxic effects of mercury ..
  33. MERCURY NEPHROTOXICITY AFTER A REDUCTION OF RENAL MASS
    RUDOLFS ZALUPS; Fiscal Year: 2000
    ..abstract_text> ..
  34. TRANSPORT AND TOXICITY OF MERCURY IN THE NEPHRON
    RUDOLFS ZALUPS; Fiscal Year: 2000
    ....
  35. TRANSPORT AND TOXICITY OF MERCURY IN THE NEPHRON
    RUDOLFS ZALUPS; Fiscal Year: 2006
    ..to date, of the mechanisms involved in the uptake of inorganic mercuric ions along pars recta segments of the proximal tubule, which are the segments of the nephron most vulnerable to the nephrotoxic effects of mercury ..
  36. Epidemiology of Immunotoxicant Exposure in Children
    Philippe Grandjean; Fiscal Year: 2007
    ..These results are expected to extend substantially the current documentation for PCB risk assessment. [unreadable] [unreadable]..
  37. Three-generation Human Study of Reproductive Effects of Marine Food Contaminants
    Philippe Grandjean; Fiscal Year: 2006
    ..Current evidence already suggests that these pathologies may already affect many populations, and the present proposal aims at identifying whether persistent organochlorine pollutants contribute to these abnormalities. ..
  38. Epidemiology of Immunotoxicant Exposure in Children
    Philippe Grandjean; Fiscal Year: 2005
    ..These results are expected to extend substantially the current documentation for PCB risk assessment. ..
  39. Epidemiology of Immunotoxicant Exposure in Children
    Philippe Grandjean; Fiscal Year: 2004
    ..These results are expected to extend substantially the current documentation for PCB risk assessment. ..
  40. Effects of perinatal endocrine disrupters in children
    Philippe Grandjean; Fiscal Year: 2004
    ..Modern statistical methods will be used to determine whether these outcome variables are associated with estrogen, thyroid, or Ah receptor abnormalities and specific contaminant exposures prenatally or postnatally. ..
  41. Effects of perinatal endocrine disrupters in children
    Philippe Grandjean; Fiscal Year: 2002
    ..Modern statistical methods will be used to determine whether these outcome variables are associated with estrogen, thyroid, or Ah receptor abnormalities and specific contaminant exposures prenatally or postnatally. ..
  42. Effects of perinatal endocrine disrupters in children
    Philippe Grandjean; Fiscal Year: 2003
    ..Modern statistical methods will be used to determine whether these outcome variables are associated with estrogen, thyroid, or Ah receptor abnormalities and specific contaminant exposures prenatally or postnatally. ..
  43. Three-generation Human Study of Reproductive Effects of Marine Food Contaminants
    PHILIPPE ADAM GRANDJEAN; Fiscal Year: 2010
    ..Current evidence already suggests that these pathologies may already affect many populations, and the present proposal aims at identifying whether persistent organochlorine pollutants contribute to these abnormalities. ..
  44. Health Effects of Lifetime Exposure to Food Contaminants
    Philippe Grandjean; Fiscal Year: 2009
    ..The results may therefore provide new information that could very likely have an impact on the preventive efforts and standard-setting of the EPA and other regulatory agencies in the U.S and elsewhere. ..
  45. Three-generation Human Study of Reproductive Effects of Marine Food Contaminants
    Philippe Grandjean; Fiscal Year: 2009
    ..Current evidence already suggests that these pathologies may already affect many populations, and the present proposal aims at identifying whether persistent organochlorine pollutants contribute to these abnormalities. ..
  46. Epidemiology of Immunotoxicant Exposure in Children
    Philippe Grandjean; Fiscal Year: 2008
    ..These results are expected to extend substantially the current documentation for PCB risk assessment. [unreadable] [unreadable]..
  47. MERCURY-ASSOCIATED NEUROBEHAVIORAL DEFICIT IN CHILDREN
    Philippe Grandjean; Fiscal Year: 2009
    ....
  48. MERCURY-ASSOCIATED NEUROBEHAVIORAL DEFICIT IN CHILDREN
    Philippe Grandjean; Fiscal Year: 2008
    ....
  49. Effects of perinatal endocrine disrupters in children
    Philippe Grandjean; Fiscal Year: 2001
    ..Modern statistical methods will be used to determine whether these outcome variables are associated with estrogen, thyroid, or Ah receptor abnormalities and specific contaminant exposures prenatally or postnatally. ..
  50. MERCURY-ASSOCIATED NEUROBEHAVIORAL DEFICIT IN CHILDREN
    PHILIPPE ADAM GRANDJEAN; Fiscal Year: 2010
    ....
  51. Health Effects of Lifetime Exposure to Food Contaminants
    Philippe Grandjean; Fiscal Year: 2007
    ..The results may therefore provide new information that could very likely have an impact on the preventive efforts and standard-setting of the EPA and other regulatory agencies in the U.S and elsewhere. ..
  52. Health Effects of Lifetime Exposure to Food Contaminants
    Philippe Grandjean; Fiscal Year: 2008
    ..The results may therefore provide new information that could very likely have an impact on the preventive efforts and standard-setting of the EPA and other regulatory agencies in the U.S and elsewhere. ..
  53. Epidemiology of Immunotoxicant Exposure in Children
    Philippe Grandjean; Fiscal Year: 2006
    ..These results are expected to extend substantially the current documentation for PCB risk assessment. [unreadable] [unreadable]..
  54. Three-generation Human Study of Reproductive Effects of Marine Food Contaminants
    Philippe Grandjean; Fiscal Year: 2008
    ..Current evidence already suggests that these pathologies may already affect many populations, and the present proposal aims at identifying whether persistent organochlorine pollutants contribute to these abnormalities. ..
  55. Effects of perinatal endocrine disrupters in children
    Philippe Grandjean; Fiscal Year: 2002
    ..Modern statistical methods will be used to determine whether these outcome variables are associated with estrogen, thyroid, or Ah receptor abnormalities and specific contaminant exposures prenatally or postnatally. ..
  56. Three-generation Human Study of Reproductive Effects of Marine Food Contaminants
    Philippe Grandjean; Fiscal Year: 2007
    ..Current evidence already suggests that these pathologies may already affect many populations, and the present proposal aims at identifying whether persistent organochlorine pollutants contribute to these abnormalities. ..
  57. Developmental neurotoxicity of ethanol
    LUCIO COSTA; Fiscal Year: 2007
    ..Altogether, these studies are aimed at elucidating novel aspects of the communication between astrocytes and neurons and at characterizing new mechanisms involved in the developmental neurotoxicity of ethanol. ..
  58. Developmental neurotoxicity of ethanol
    LUCIO COSTA; Fiscal Year: 2008
    ..Altogether, these studies are aimed at elucidating novel aspects of the communication between astrocytes and neurons and at characterizing new mechanisms involved in the developmental neurotoxicity of ethanol. ..
  59. Developmental neurotoxicity of ethanol
    LUCIO COSTA; Fiscal Year: 2009
    ..Altogether, these studies are aimed at elucidating novel aspects of the communication between astrocytes and neurons and at characterizing new mechanisms involved in the developmental neurotoxicity of ethanol. ..
  60. Developmental neurotoxicity of ethanol
    LUCIO COSTA; Fiscal Year: 2008
    ..Altogether, these studies are aimed at elucidating novel aspects of the communication between astrocytes and neurons and at characterizing new mechanisms involved in the developmental neurotoxicity of ethanol. ..
  61. Developmental neurotoxicity of ethanol
    LUCIO COSTA; Fiscal Year: 2009
    ..Altogether, these studies are aimed at elucidating novel aspects of the communication between astrocytes and neurons and at characterizing new mechanisms involved in the developmental neurotoxicity of ethanol. ..
  62. ETHANOL AND PHOSPHOINOSITIDES DURING BRAIN DEVELOPMENT
    LUCIO COSTA; Fiscal Year: 2000
    ..2. To investigate the molecular pathways involved in the observed inhibition by ethanol of the mitogenic action of acetylcholine in astrocytes. ..
  63. ETHANOL AND PHOSPHOINOSITIDES DURING BRAIN DEVELOPMENT
    LUCIO COSTA; Fiscal Year: 1991
    ....
  64. ETHANOL AND PHOSPHOINOSITIDES DURING BRAIN DEVELOPMENT
    LUCIO COSTA; Fiscal Year: 1993
    ....
  65. ETHANOL AND PHOSPHOINOSITIDES DURING BRAIN DEVELOPMENT
    LUCIO COSTA; Fiscal Year: 1999
    ..2. To investigate the molecular pathways involved in the observed inhibition by ethanol of the mitogenic action of acetylcholine in astrocytes. ..
  66. BAYESIAN BIOMARKER MODELS FOR CANCER GENETICS STUDIES
    SARAH THURSTON; Fiscal Year: 2004
    ..abstract_text> ..
  67. ETHANOL AND PHOSPHOINOSITIDES DURING BRAIN DEVELOPMENT
    LUCIO COSTA; Fiscal Year: 1992
    ....
  68. MECHANISM OF SELENOPROTEIN SYNTHESIS IN EUKARYOTES
    Marla Berry; Fiscal Year: 2000
    ..Finally, proposed studies include investigation of the functions and mechanisms of regulation of newly identified selenoproteins. ..
  69. Breastfeeding Promotion RCT and Child Metabolic Syndrome
    Emily Oken; Fiscal Year: 2009
    ....
  70. MECHANISM OF SELENOPROTEIN SYNTHESIS IN EUKARYOTES
    Marla Berry; Fiscal Year: 1999
    ..Finally, proposed studies include investigation of the functions and mechanisms of regulation of newly identified selenoproteins. ..
  71. ALTERNATIVE MECHANISMS OF UGA CODON RECOGNITION
    Marla Berry; Fiscal Year: 1999
    ..Continuing studies of this process will surely unveil new and exciting information about the complex workings of the translation machinery. ..
  72. Mechanism of selenoprotein synthesis
    Marla Berry; Fiscal Year: 2008
    ..III. Investigate interactions between EFsec, SBP2 and their interaction partners, and the functions of these interaction partners in selenoprotein synthesis. ..
  73. SELENOPROTEIN P FUNCTION AND REGULATION OF EXPRESSION
    Marla Berry; Fiscal Year: 2003
    ..3) Expression and function of selenoprotein P in zebra fish. In situ hybridization and determination of requirements and function of selenoprotein P in Zebra fish will be conducted. ..
  74. ALTERNATIVE MECHANISMS OF UGA CODON RECOGNITION
    Marla Berry; Fiscal Year: 2005
    ..Continuing studies of this process will surely unveil new and exciting information about the complex workings of the translation machinery. ..
  75. BIOSTATISTICAL TOPICS IN CARCINOGENICITY AND TERATOLOGY
    Louise Ryan; Fiscal Year: 2005
    ..Both Bayesian and frequentist approaches will be used. ..
  76. Mechanism of selenoprotein synthesis
    Marla Berry; Fiscal Year: 2005
    ..III. Investigate interactions between EFsec, SBP2 and their interaction partners, and the functions of these interaction partners in selenoprotein synthesis. ..
  77. SELENOPROTEIN P FUNCTION AND REGULATION OF EXPRESSION
    Marla Berry; Fiscal Year: 2004
    ....
  78. SELENOPROTEIN P FUNCTION AND REGULATION OF EXPRESSION
    Marla Berry; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  79. The Youth Employment Training Pilot Program
    Henry Anderson; Fiscal Year: 2002
    ..Data from the anonymous school based surveys will be used to determine whether youth who have obtained a work permit are less likely to experience a work related injury. ..
  80. ALTERNATIVE MECHANISMS OF UGA CODON RECOGNITION
    Marla Berry; Fiscal Year: 2002
    ..Continuing studies of this process will surely unveil new and exciting information about the complex workings of the translation machinery. ..