gadolinium dtpa

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..To determine the added value of hepatobiliary phase images in gadoxetic acid-enhanced magnetic resonance (MR) imaging in the evaluation of hepatocellular carcinoma (HCC)...

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..We have developed a robust and noninvasive technique, equilibrium contrast CMR (EQ-CMR) to quantify diffuse fibrosis and have validated it against the current gold standard of surgical myocardial biopsy...

..In conclusion, in the studied cohort, there was a linear relation between scar size and ejection fraction and LV volumes. This relation was independent of scar location and transmurality...

..To prospectively compare gadoxetate disodium-enhanced magnetic resonance (MR) imaging with multiphasic 64-section multidetector computed tomography (CT) in the detection of hepatocellular carcinoma (HCC) in patients with cirrhosis...

..Finally, we examined which segmental transmural threshold of scarring best predicted global LV recovery...

..We hypothesized that the results of contrast-enhanced MRI can be used to predict whether regions of abnormal ventricular contraction will improve after revascularization in patients with coronary artery disease...

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..To evaluate the time course of delayed gadolinium enhancement of infarcted myocardium by using serial contrast agent-enhanced (CE) cardiac magnetic resonance (MR) images obtained during the acute, subacute, and chronic stages of infarction...

..In conclusion, it is expected that readers will gain deeper insight into the latest progress and updated diagnosis and treatment of HCC described in this review...

..CONCLUSIONS: These observations suggests that myocardial fibrosis occurs in AFD and may contribute to the hypertrophy and the natural history of the disease...

..However, some patients have no coronary obstruction on angiography, leading to diagnostic uncertainty. We evaluated the incremental diagnostic value of cardiovascular magnetic resonance (CMR) in these patients...

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..2% at 6 and 30 min, respectively; p = NS). CONCLUSIONS: When an objective technique is used to define MI size by CE-MRI, accurate infarct size measurements can be obtained from images obtained up to 30 min after contrast administration...

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..Phase-sensitive detection also has the advantage of decreasing the sensitivity to changes in tissue T(1) with increasing delay from contrast agent injection...

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..No comparative studies have been conducted comparing the advantages or disadvantages of all three agents directly against each other...

..For the dual bolus approach a significant relative decrease of 30% (P<0.001) was found for the coefficient of segmental MPR variation, which may allow a more reliable detection of hypoperfused segments in clinical studies...

..7T. While the IR sequence delivers better overall SNR and CNR, the T1-CF allows concomitant assessment of global cardiac function with a much shorter acquisition time...

..In addition, eosinophilic abscess and focal eosinophilic infiltration showed different MRI findings from each other...

..We aimed to characterize the tissue changes within the perfusion bed of infarct-related vessels in patients with acutely reperfused myocardial infarction (MI) using cardiovascular magnetic resonance (CMR)...

..To compare the findings of magnetic resonance (MR) imaging with those of computed tomography (CT) of focal liver lesions related to peripheral eosinophilia...

..This study analyzed the accuracy of gadolinium-enhanced cardiovascular magnetic resonance (CMR) for the diagnosis of cardiac sarcoidosis (CS)...

..65). CONCLUSION: Delayed enhancement occurs frequently in patients after correction for tetralogy of Fallot. Delayed enhancement in the RVOT was associated with RVOT dilatation, which adversely affects right ventricular hemodynamics...

..4T, and to obtain the maximal contrast between the infarcted and the viable myocardium...

..Perfusion imaging defines the physiology and angiography in the anatomy of coronary artery disease...

..007). CONCLUSION: The FACT algorithm accurately measured MI size on delayed enhancement MR imaging in vivo and ex vivo. The FACT algorithm was also more accurate than human manual contouring and simple intensity thresholding approaches...

..These findings should help to distinguish focal eosinophilic infiltration, especially from metastasis in patients with malignancy...

..We evaluated the accuracy of MRI and MCE, using Single Photon Emission Computed Tomography (SPECT) imaging as reference technique...

..The purpose of this study is to develop a noninvasive method of quantitation of the hepatic function using Gd-EOB-DTPA through the deconvolution analysis...

..To compare the effects of gadolinium concentration on intermediate-weighted fast inversion-recovery and T2-weighted fast spin-echo magnetic resonance (MR) images by using a saline bag model of the kidney...

..7 min for K(trans) and v(e)). Reliable estimation of the fractional blood plasma volume (v(p)) was only achieved with MCAs. In conclusion, MCAs provided superior reliability for pharmacokinetic parameter estimation compared to SCAs...

..Development and test of a saturation-recovery TrueFISP (SR-Trufi) pulse sequence for myocardial perfusion MR imaging (MRI) using improved gradient hardware...

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..To assess the feasibility to use dynamic hepatocyte-specific contrast-enhanced MRI (DHCE-MRI) as an imaging-based liver function test, and to compare two methods for deconvolutional analysis (DA) in healthy human subjects...

..J. Magn. Reson. Imaging 2000;12:400-410...

..Data were acquired on a 3-T scanner, using an approach similar to clinical acquisition protocols, thus facilitating translation of imaging findings between rodent and human studies...

..To investigate the blood pool agent gadofosveset trisodium for first-pass, dynamic peripheral contrast-enhanced magnetic resonance angiography (pMRA), and compare the results with a conventional gadolinium contrast agent...

..The aim of this study was to determine whether the hepatic uptake and excretion of Gd-EOB-DTPA differ between patients with primary biliary cirrhosis (PBC) and healthy controls, and whether differences could be quantified...

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..The feasibility of the technique for in vivo MRI and increased lesion contrast is demonstrated. The results indicate that this technique may improve detection of malignant breast tissue...

..There may be a value of enhanced MR cholangiopancreatography when unenhanced MR cholangiopancreatography is not sufficient...

..Examination time cannot be extended if the contrast does not take effect on T(2)-weighted MRCP within 20 min after administration. We attempted to assess the change in signal of T(2)-weighted MRCP by excretion of Gd-EOB-DTPA...

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..05). CONCLUSIONS: MRI can accurately assess both infarct size and cardiac function in intact mice early after large, reperfused MI, revealing the existence of contractile dysfunction in noninfarcted regions of the heart...

..Diffusion-weighted MRI with EPI is a useful technique for assessing the tumor cellularity and grading of gliomas. This information is not obtained with conventional MRI and is useful for the diagnosis and characterization of gliomas...

..We compared the diagnostic performance of gadoxetic acid-enhanced MRI with that of triple-phase 16-, 40-, and 64-MDCT in the preoperative detection of hepatocellular carcinoma (HCC)...

..33%, p = 0.01). CONCLUSIONS: Gadolinium CMR reveals myocardial hyperenhancement in HCM. The extent of hyperenhancement is associated with progressive ventricular dilation and markers of sudden death...

..To retrospectively review data in 13 patients with biopsy-confirmed nephrogenic systemic fibrosis (NSF), assess the associated risk factors, and report the incidence of NSF at the authors' institution...

..In this study we assessed the prognostic value of late gadolinium enhancement (LGE) and gadolinium kinetics in cardiac amyloidosis in a prospective longitudinal study...

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..The early hypoenhanced regions, which represent only the fraction of infarcted tissue with concomitant microvascular obstruction, greatly underestimate the amount of irreversibly injured myocardium present after acute MI...

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..This modality may qualify for its clinical application in the management of coronary artery disease...

..The purpose of this study was to investigate a noninvasive method for quantifying diffuse myocardial fibrosis with cardiac magnetic resonance imaging (CMRI)...

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..To describe the additional benefit in detection and differential diagnosis of peri- and intrasplenic tumors by use of an superparamagnetic iron oxide contrast agent (SPIO)...

..Sulcal hyperintensity is significantly associated with subsequent HT...

..The use of a standardized classification allows to assess the relative role of PET. A similar approach could be useful and may serve as a template for the evaluation of the integration of other new imaging modalities in radiosurgery...

..Longitudinal studies are necessary to find or demonstrate the parameter that is more sensitive to disease activity...

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..03). CONCLUSION: The combination of the three methods of MR perfusion, angiography, and 3H ventilation imaging may provide complementary information on abnormal lung anatomy and function...

..MRI was moderately superior to dual-phase spiral CT for lesion detection, and was markedly superior for lesion characterization, with these differences having clinical significance...

..Our objective was to assess and compare the patterns of late enhancement (LE) in contrast-enhanced cardiac MRI caused by myocardial infarction and different myocardial diseases that are not related to ischemic infarction...

..Therefore, this study proposes 3-phase dynamic imaging with 2-way subtraction and an MIP image as one of the standard protocols of breast MR imaging...

..The aim of this study was to compare routine CR and MRI to investigate erosion numbers and morphology to determine whether hand OA in general is a more erosive disease than previously recognised...

..CONCLUSION: Three-dimensional dynamic contrast-enhanced MRI has potential for assessment of disease severity as indicated by PVR and MPAP in patients with PPH...

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..6% respectively, while on axial T1W-FLAIR BLADE they were 100% and 100%. T1W-FLAIR BLADE seems to be capable of replacing T1W-SE, at least for axial post-contrast imaging to detect brain metastases...

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..Parameters derived from 3 different analyses were correlated with histopathologically confirmed grade in gliomas to determine which parameters best predict tumor grade...

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..To establish an MR factor analysis technique for two-dimensional (2D) MR dynamic structures of benign and malignant salivary gland tumors...

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..The aim was to assess the role of quantitative MRI in the evaluation of AS treatment efficacy...

..The aim of the current study was to show if contrast-to-noise ratio (CNR) could be improved without loss of diagnostic accuracy if a phase-sensitive inversion recovery (PSIR) single-shot TrueFISP sequence is used at 3.0 T instead of 1.5 T...

..This paper provides an overview of the practical issues associated with obtaining high-quality scans as well as an introduction into the interpretation of MR urograms...

..Interpatient variability in DCE MRI was only partially reduced by normalization to muscle. DCE MRI of the prostate discriminated PZ cancer from normal PZ tissues and predominantly stromal and glandular BPH...

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..In detection of brain metastases at 3T magnetic resonance (MR) imaging, SPACE imaging may provide an effective, alternative approach to MP-RAGE imaging for 3D T(1)-weighted imaging...

..The method is demonstrated experimentally with phantoms, in vivo angiographic animal studies, and in vivo human studies...

..CONCLUSION: The StdTTP quantitatively describes the hemodynamic impairment in cerebral hemispheres supplied by a stenosed or occluded ICA. An stdTTP value of > 3.5 s, as has been postulated, seems to point out hemodynamic impairment...

..For this reason, MRI of this nerve does not enable us to draw conclusions on the etiology of idiopathic peripheral facial paralysis...

..Focal pancreatitis (FP) is a confined inflammation that mimics a pancreatic mass. Its imaging diagnosis is important to avoid unnecessary procedures...

..5 T in single and cumulative triple dose, and improves MR venography at 3 T with increase in spatial resolution within the same measurement time, thus providing more detailed information...

..To assess if T2-weighted magnetic resonance (MR) imaging provides added diagnostic value in combination with dynamic gadolinium-enhanced MR imaging in the detection and characterization of nodular lesions in cirrhotic liver...

..Despite some limitations, a perfusion/diffusion mismatch can provide a working estimate of the ischemic penumbra in hyperacute stroke and has successfully been used to triage patients...

..5 t...

..To both develop and use a tissue signature method for the identification and classification of breast lesions and healthy breast tissue with magnetic resonance (MR) imaging...

..The purpose of this work was to compare the incidence and pattern of transient peritumoral parenchymal enhancement for cavernous hemangioma and hepatocellular carcinoma during dynamic MRI of the liver...

..Matrix metalloproteinase inhibitors will be studied that have the potential to be used to prevent the death of vulnerable cells in the white matter. ..

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..The goal of this project is to develop and evaluate a novel series of glycopolymer-Gd3+ chelates for use as MRI contrast agents to improve cardiovascular MRI for early and accurate detection of acute myocardial afflictions. ..

..The utility of the comprehensive exam will be determined by correlating pre- intervention MRI-determined parameters with both clinical outcome measures and post-intervention MRI-determined parameters. ..

..A final goal will be to combine oxygen manipulative agents with fractionated radiotherapy, in order to better understand the combined physiological effects and to provide a basis for selecting optimal time points. ..

..This knowledge can facilitate timely intervention of lung cancer to achieve personalized medicine. ..

..This knowledge can facilitate timely intervention of lung cancer to achieve personalized medicine. ..

..MRI methods will be developed using both standard gadolinium-DTPA and gadolinium-encapsulating immunoliposomes. ..

..These studies will determine the role of protease-mediated nflammation in the progressive form of SIVD, and could lead to novel treatments to suppress proteases. ..

..These studies will determine the role of protease-mediated nflammation in the progressive form of SIVD, and could lead to novel treatments to suppress proteases. ..

..These studies will determine the role of protease-mediated nflammation in the progressive form of SIVD, and could lead to novel treatments to suppress proteases. ..

..If successful, this study can further be translated into clinical applications, since related iron oxides have already been tested in clinical trials. ..

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..e., BBB opening) and both will be functions of the variations in BBB associated proteins and/or brain swelling; and 2) the size of these changes are correlated over time, ROI, and treatment. ..

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..This Shared Instrumentation Grant will partially supply the funds to bring the present MRI/MRS system up to current standards, with HFHS supplying the rest. ..

..We hypothesize that the combined analysis of contrast enhanced MRI and diffusion MRI data will provide predictive, non-invasive measurements of tumor response to treatment. ..

..e., BBB opening) and both will be functions of the variations in BBB associated proteins and/or brain swelling;and 2) the size of these changes are correlated over time, ROI, and treatment. ..

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..We propose the development of a novel method for assessment of diffuse fibrosis in the heart muscle with magnetic resonance imaging. ..

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..In addition, it will provide much-needed data to be shared with the larger scientific community on serologic and genetic risk factors for CKD, a growing public health concern in the US. ..

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..In addition to generating valuable, new data, this project will allow Peter Kochunov to undertake rigorous training in analytical genomics and accumulate first hand experience in executing genomic studies. ..

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..The high resolution 3D radial viability technique will be validated in animals, and also used in patients. ..

..54 subjects will serve in each experimental group and they will be followed for a minimum of 3-years. ..

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..UCLA has new state-of-the-art MRI and PET imaging devices together with active collaborating teams having expertise in stroke clinical management (both acute and rehabilitative), in MRI scanning and in PET scanning. ..

..The goal is to optimize the MRA method and to determine if the use of contrast agents provides any clinical benefit. ..

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..Furthermore, the scientific concept proposed here may lead to an innovative approach to investigate visual function/dysfunction in migraine, and may provide a new insight into migraine pathophysiology. ..

..The proposed research also has the potential to facilitate a greater understanding of cardiomyocyte apoptosis and accelerate the development of novel cardioprotective strategies. ..