gadolinium dtpa

Summary

Summary: A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see PENTETIC ACID), that is given to enhance the image in cranial and spinal MRIs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p706)

Top Publications

  1. ncbi The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction
    R J Kim
    Feinberg Cardiovascular Research Institute, and Department of Medicine, Northwestern University Medical School, Chicago, IL 60611 3008, USA
    N Engl J Med 343:1445-53. 2000
  2. ncbi Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols
    P S Tofts
    Department of Clinical Neurology, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    J Magn Reson Imaging 10:223-32. 1999
  3. ncbi Equilibrium contrast cardiovascular magnetic resonance for the measurement of diffuse myocardial fibrosis: preliminary validation in humans
    Andrew S Flett
    Department of Medicine, University College London Hospitals National Health Service Trust, The Heart Hospital, 16 18 Westmoreland St, London W1G 8PH, United Kingdom
    Circulation 122:138-44. 2010
  4. ncbi Evaluation of diffuse myocardial fibrosis in heart failure with cardiac magnetic resonance contrast-enhanced T1 mapping
    Leah Iles
    Alfred Hospital and Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    J Am Coll Cardiol 52:1574-80. 2008
  5. pmc Shortened Modified Look-Locker Inversion recovery (ShMOLLI) for clinical myocardial T1-mapping at 1.5 and 3 T within a 9 heartbeat breathhold
    Stefan K Piechnik
    University of Oxford Centre for Clinical Magnetic Resonance Research, Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK
    J Cardiovasc Magn Reson 12:69. 2010
  6. ncbi Optimization and validation of a fully-integrated pulse sequence for modified look-locker inversion-recovery (MOLLI) T1 mapping of the heart
    Daniel R Messroghli
    Cardiac MRI Unit, Franz Volhard Klinik, Charite Campus Buch, Universitatsmedizin Berlin, HELIOS Klinikum Berlin, Germany
    J Magn Reson Imaging 26:1081-6. 2007
  7. pmc Phase-sensitive inversion recovery for detecting myocardial infarction using gadolinium-delayed hyperenhancement
    Peter Kellman
    Laboratory of Cardiac Energetics, National Institutes of Health, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892 1061, USA
    Magn Reson Med 47:372-83. 2002
  8. pmc Quantification of diffuse myocardial fibrosis and its association with myocardial dysfunction in congenital heart disease
    Craig S Broberg
    Adult Congenital Heart Disease Program, Oregon Health and Science University, Portland, Ore, USA
    Circ Cardiovasc Imaging 3:727-34. 2010
  9. ncbi Detection and characterisation of focal liver lesions in colorectal carcinoma patients: comparison of diffusion-weighted and Gd-EOB-DTPA enhanced MR imaging
    D Lowenthal
    Department of Radiology and Nuclear Medicine, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Eur Radiol 21:832-40. 2011
  10. ncbi Detection and characterization of focal liver lesions: a Japanese phase III, multicenter comparison between gadoxetic acid disodium-enhanced magnetic resonance imaging and contrast-enhanced computed tomography predominantly in patients with hepatocellular
    Tomoaki Ichikawa
    Department of Radiology, University of Yamanashi, School of Medicine, Yamanashi, Japan
    Invest Radiol 45:133-41. 2010

Detail Information

Publications275 found, 100 shown here

  1. ncbi The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction
    R J Kim
    Feinberg Cardiovascular Research Institute, and Department of Medicine, Northwestern University Medical School, Chicago, IL 60611 3008, USA
    N Engl J Med 343:1445-53. 2000
    ..We hypothesized that the results of contrast-enhanced MRI can be used to predict whether regions of abnormal ventricular contraction will improve after revascularization in patients with coronary artery disease...
  2. ncbi Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols
    P S Tofts
    Department of Clinical Neurology, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    J Magn Reson Imaging 10:223-32. 1999
    ..We relate these quantities to previously published work from our groups; our future publications will refer to these standardized terms, and we propose that these be adopted as international standards...
  3. ncbi Equilibrium contrast cardiovascular magnetic resonance for the measurement of diffuse myocardial fibrosis: preliminary validation in humans
    Andrew S Flett
    Department of Medicine, University College London Hospitals National Health Service Trust, The Heart Hospital, 16 18 Westmoreland St, London W1G 8PH, United Kingdom
    Circulation 122:138-44. 2010
    ..We have developed a robust and noninvasive technique, equilibrium contrast CMR (EQ-CMR) to quantify diffuse fibrosis and have validated it against the current gold standard of surgical myocardial biopsy...
  4. ncbi Evaluation of diffuse myocardial fibrosis in heart failure with cardiac magnetic resonance contrast-enhanced T1 mapping
    Leah Iles
    Alfred Hospital and Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    J Am Coll Cardiol 52:1574-80. 2008
    ..The purpose of this study was to investigate a noninvasive method for quantifying diffuse myocardial fibrosis with cardiac magnetic resonance imaging (CMRI)...
  5. pmc Shortened Modified Look-Locker Inversion recovery (ShMOLLI) for clinical myocardial T1-mapping at 1.5 and 3 T within a 9 heartbeat breathhold
    Stefan K Piechnik
    University of Oxford Centre for Clinical Magnetic Resonance Research, Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK
    J Cardiovasc Magn Reson 12:69. 2010
    ..In this work we propose and validate a novel, clinically applicable, pulse sequence for myocardial T1-mapping that is compatible with typical limits for end-expiration breath-holding in patients...
  6. ncbi Optimization and validation of a fully-integrated pulse sequence for modified look-locker inversion-recovery (MOLLI) T1 mapping of the heart
    Daniel R Messroghli
    Cardiac MRI Unit, Franz Volhard Klinik, Charite Campus Buch, Universitatsmedizin Berlin, HELIOS Klinikum Berlin, Germany
    J Magn Reson Imaging 26:1081-6. 2007
    ..To optimize and validate a fully-integrated version of modified Look-Locker inversion-recovery (MOLLI) for clinical single-breathhold cardiac T1 mapping...
  7. pmc Phase-sensitive inversion recovery for detecting myocardial infarction using gadolinium-delayed hyperenhancement
    Peter Kellman
    Laboratory of Cardiac Energetics, National Institutes of Health, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892 1061, USA
    Magn Reson Med 47:372-83. 2002
    ..Phase-sensitive detection also has the advantage of decreasing the sensitivity to changes in tissue T(1) with increasing delay from contrast agent injection...
  8. pmc Quantification of diffuse myocardial fibrosis and its association with myocardial dysfunction in congenital heart disease
    Craig S Broberg
    Adult Congenital Heart Disease Program, Oregon Health and Science University, Portland, Ore, USA
    Circ Cardiovasc Imaging 3:727-34. 2010
    ..the etiology of ventricular dysfunction in adult congenital heart disease (ACHD) is not well understood. Diffuse fibrosis is a likely common final pathway and is quantifiable using MRI...
  9. ncbi Detection and characterisation of focal liver lesions in colorectal carcinoma patients: comparison of diffusion-weighted and Gd-EOB-DTPA enhanced MR imaging
    D Lowenthal
    Department of Radiology and Nuclear Medicine, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Eur Radiol 21:832-40. 2011
    ..To compare diffusion-weighted imaging (DWI) and Gd-EOB-DTPA-enhanced magnetic resonance (MR) imaging for the detection and characterisation of focal liver lesions (FLLs) in patients with colorectal carcinoma...
  10. ncbi Detection and characterization of focal liver lesions: a Japanese phase III, multicenter comparison between gadoxetic acid disodium-enhanced magnetic resonance imaging and contrast-enhanced computed tomography predominantly in patients with hepatocellular
    Tomoaki Ichikawa
    Department of Radiology, University of Yamanashi, School of Medicine, Yamanashi, Japan
    Invest Radiol 45:133-41. 2010
    ....
  11. ncbi Hepatocellular carcinoma: hepatocyte-selective enhancement at gadoxetic acid-enhanced MR imaging--correlation with expression of sinusoidal and canalicular transporters and bile accumulation
    Takahiro Tsuboyama
    Department of Radiology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Radiology 255:824-33. 2010
    ..To investigate the mechanism of enhancement of hepatocellular carcinoma (HCC) on gadoxetic acid-enhanced hepatobiliary phase magnetic resonance (MR) images and to characterize HCC thus enhanced...
  12. ncbi The histologic basis of late gadolinium enhancement cardiovascular magnetic resonance in hypertrophic cardiomyopathy
    James C C Moon
    Centre for Advanced Magnetic Resonance in Cardiology CAMRIC, London, United Kingdom
    J Am Coll Cardiol 43:2260-4. 2004
    ..We sought to identify the histologic basis of myocardial late gadolinium enhancement cardiovascular magnetic resonance (CMR) in hypertrophic cardiomyopathy (HCM)...
  13. ncbi Nephrogenic systemic fibrosis: suspected causative role of gadodiamide used for contrast-enhanced magnetic resonance imaging
    Peter Marckmann
    Department of Nephrology, Copenhagen University Hospital at Herlev, DK 2730 Herlev, Denmark
    J Am Soc Nephrol 17:2359-62. 2006
    ..No other exposure/event than gadodiamide that was common to more than a minority of the patients could be identified. These findings indicate that gadodiamide plays a causative role in nephrogenic systemic fibrosis...
  14. ncbi Added value of gadoxetic acid-enhanced hepatobiliary phase MR imaging in the diagnosis of hepatocellular carcinoma
    Sung Soo Ahn
    Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Shinchon Dong 134, Seodaemun gu, Seoul 120 752, Korea
    Radiology 255:459-66. 2010
    ..To determine the added value of hepatobiliary phase images in gadoxetic acid-enhanced magnetic resonance (MR) imaging in the evaluation of hepatocellular carcinoma (HCC)...
  15. ncbi Measurement of the gadopentetate dimeglumine partition coefficient in human myocardium in vivo: normal distribution and elevation in acute and chronic infarction
    S J Flacke
    Cardiovascular Division, Barnes-Jewish Hospital at Washington University Medical Center, St Louis, MO, USA
    Radiology 218:703-10. 2001
    ..CONCLUSION: Quantification of the lambda in vivo allows differentiation between normal and acutely or chronically infarcted myocardium, with high sensitivity and specificity...
  16. ncbi Quantitative pharmacokinetic analysis of DCE-MRI data without an arterial input function: a reference region model
    Thomas E Yankeelov
    Institute of Imaging Science, Vanderbilt University, Nashville, TN 37232 2675, USA
    Magn Reson Imaging 23:519-29. 2005
    ..This allows for acquiring images with higher spatial resolution and/or SNR, and therefore, increased ability to probe tissue heterogeneity...
  17. ncbi Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis?
    Thomas Grobner
    Department of Nephrology, General Hopsital of Wiener Neustadt, A 2700 Wiener Neustadt, Austria
    Nephrol Dial Transplant 21:1104-8. 2006
  18. ncbi Diagnostic efficacy of gadoxetic acid (Primovist)-enhanced MRI and spiral CT for a therapeutic strategy: comparison with intraoperative and histopathologic findings in focal liver lesions
    Renate Hammerstingl
    Institute of Diagnostic and Interventional Radiology, Johann Wolfgang Goethe University, ZRad, Haus 23 C, Theodor Stern Kai 7, 60590, Frankfurt am Main, Germany
    Eur Radiol 18:457-67. 2008
    ..0%). A change in surgical therapy was documented in 19 of 131 patients (14.5%) post Gd-EOB-DTPA-enhanced MRI. Gd-EOB-DTPA-enhanced MRI was superior in the diagnosis and therapeutic management of focal liver lesions compared with CT...
  19. ncbi Comparison of gadolinium-EOB-DTPA-enhanced and diffusion-weighted liver MRI for detection of small hepatic metastases
    Kotaro Shimada
    Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto, 606 8507, Japan
    Eur Radiol 20:2690-8. 2010
    ..To compare the accuracy of gadolinium ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI with that of diffusion-weighted MRI (DWI) in the detection of small hepatic metastases (2 cm or smaller)...
  20. ncbi Accurate and objective infarct sizing by contrast-enhanced magnetic resonance imaging in a canine myocardial infarction model
    Luciano C Amado
    Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 2187, USA
    J Am Coll Cardiol 44:2383-9. 2004
    ....
  21. ncbi Key factors in the acquisition of contrast kinetic data for oncology
    J L Evelhoch
    Cancer Biology Program, Barbara Ann Karmanos Cancer Institute, and Departments of Internal Medicine and Radiology, Wayne State University, Vaitkevicius MR Center, Detroit, Michigan 48201, USA
    J Magn Reson Imaging 10:254-9. 1999
    ..This review considers these factors and, when possible, makes specific recommendations for addressing them experimentally...
  22. ncbi Hepatobiliary contrast agents for contrast-enhanced MRI of the liver: properties, clinical development and applications
    Peter Reimer
    Department of Radiology, Stadtisches Klinikum Karlsruhe, Academic Teaching Hospital of the University of Freiburg, Moltkestrasse 90, 76133 Karlsruhe, Germany
    Eur Radiol 14:559-78. 2004
    ..No comparative studies have been conducted comparing the advantages or disadvantages of all three agents directly against each other...
  23. ncbi Efficacy and safety of MR imaging with liver-specific contrast agent: U.S. multicenter phase III study
    David A Bluemke
    Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287, USA
    Radiology 237:89-98. 2005
    ....
  24. ncbi Cardiovascular magnetic resonance in cardiac amyloidosis
    Alicia Maria Maceira
    Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, London, UK
    Circulation 111:186-93. 2005
    ..Cardiac amyloidosis can be diagnostically challenging. Cardiovascular magnetic resonance (CMR) can assess abnormal myocardial interstitium...
  25. ncbi Enhancement of focal liver lesions at gadoxetic acid-enhanced MR imaging: correlation with histopathologic findings and spiral CT--initial observations
    Alexander Huppertz
    Department of Clinical Radiology and Institute of Pathology, Ludwig Maximilians University, Munich, Germany
    Radiology 234:468-78. 2005
    ....
  26. ncbi Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) in early knee osteoarthritis
    Carl Johan Tiderius
    Department of Orthopedics, Diagnostic Radiology and Radiation Physics, Malmo University Hospital, Lund University, Sweden
    Magn Reson Med 49:488-92. 2003
    ..5 than at 3 hr in the diseased but not in the reference compartment. In conclusion, dGEMRIC can identify GAG loss in early stage cartilage disease with a higher sensitivity at 1.5 than 3 hr...
  27. ncbi Focal liver lesion detection and characterization with diffusion-weighted MR imaging: comparison with standard breath-hold T2-weighted imaging
    Tejas Parikh
    Department of Radiology, New York University Medical Center, 530 First Ave, MRI, New York, NY 10016, USA
    Radiology 246:812-22. 2008
    ....
  28. ncbi Extent of left ventricular scar predicts outcomes in ischemic cardiomyopathy patients with significantly reduced systolic function: a delayed hyperenhancement cardiac magnetic resonance study
    Deborah H Kwon
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    JACC Cardiovasc Imaging 2:34-44. 2009
    ....
  29. ncbi Cirrhotic rat liver: reference to transporter activity and morphologic changes in bile canaliculi--gadoxetic acid-enhanced MR imaging
    Natsuko Tsuda
    Department of Diagnostic Imaging Medical Affairs, Bayer Yakuhin, Kita ku, Osaka, Osaka, Japan
    Radiology 256:767-73. 2010
    ....
  30. ncbi Prediction of biomechanical properties of articular cartilage with quantitative magnetic resonance imaging
    Miika T Nieminen
    Department of Anatomy, University of Kuopio, Kuopio, Finland
    J Biomech 37:321-8. 2004
    ..The results are encouraging with respect to functional imaging of cartilage, although in vivo applicability may be limited by the inferior resolution of clinical MRI instruments...
  31. ncbi "Pseudo washout" sign in high-flow hepatic hemangioma on gadoxetic acid contrast-enhanced MRI mimicking hypervascular tumor
    Kyung Won Doo
    Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine, 80 Guro dong, Guro Gu, Seoul 152 703, Korea
    AJR Am J Roentgenol 193:W490-6. 2009
    ..The purpose of this article is to describe the "pseudo washout" sign of high-flow hepatic hemangioma that mimics hypervascular tumor on gadoxetic acid-enhanced MRI...
  32. pmc Detection of neovessels in atherosclerotic plaques of rabbits using dynamic contrast enhanced MRI and 18F-FDG PET
    Claudia Calcagno
    FAHA, FACC, Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1234, New York, NY 10029, USA
    Arterioscler Thromb Vasc Biol 28:1311-7. 2008
    ..Our aim was to test 2 techniques, black blood dynamic contrast enhanced MRI (DCE-MRI) and 18-fluorine-fluorodeoxyglucose (18F-FDG) PET, to quantify inflammation expressed as plaque neovessels content in a rabbit model of atherosclerosis...
  33. ncbi Paradoxical high signal intensity of hepatocellular carcinoma in the hepatobiliary phase of Gd-EOB-DTPA enhanced MRI: initial experience
    Seun Ah Lee
    Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine, Seoul 152 703, Korea
    Magn Reson Imaging 29:83-90. 2011
    ..To describe the paradoxical high signal intensity of hepatocellular carcinoma (HCC) in the hepatobiliary phase on gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI)...
  34. ncbi Comparison of two different injection rates of gadoxetic acid for arterial phase MRI of the liver
    Sang Hoon Chung
    Department of Radiology and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
    J Magn Reson Imaging 31:365-72. 2010
    ..To compare two different injection rates for gadoxetic acid-enhanced hepatic arterial phase images on hepatic dynamic MRI...
  35. pmc Small (≤ 2 cm) hepatocellular carcinoma in patients with chronic liver disease: comparison of gadoxetic acid-enhanced 3.0 T MRI and multiphasic 64-multirow detector CT
    J Hwang
    Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Br J Radiol 85:e314-22. 2012
    ..0 T with that of multiphasic 64-multirow detector CT (MDCT) for the detection of small (≤2 cm) hepatocellular carcinoma (HCC) in patients with chronic liver disease...
  36. ncbi Equilibrium water exchange between the intra- and extracellular spaces of mammalian brain
    James D Quirk
    Department of Chemistry, Washington University, St Louis, Missouri 63110, USA
    Magn Reson Med 50:493-9. 2003
    ..The data are obtained in an imaging mode that permits detection of regional variations in these parameters...
  37. ncbi Nephrogenic systemic fibrosis: risk factors and incidence estimation
    Elizabeth A Sadowski
    Department of Radiology, University of Wisconsin, Madison, WI 53792 3252, USA
    Radiology 243:148-57. 2007
    ..To retrospectively review data in 13 patients with biopsy-confirmed nephrogenic systemic fibrosis (NSF), assess the associated risk factors, and report the incidence of NSF at the authors' institution...
  38. ncbi Liver parenchymal enhancement of hepatocyte-phase images in Gd-EOB-DTPA-enhanced MR imaging: which biological markers of the liver function affect the enhancement?
    Utaroh Motosugi
    Department of Radiology, University of Yamanashi, Chuo shi, Japan
    J Magn Reson Imaging 30:1042-6. 2009
    ..To clarify the factors that predict enhancement of the liver parenchyma in hepatocyte-phase of gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced MR imaging...
  39. ncbi Gadoxetic acid disodium-enhanced magnetic resonance imaging for biliary and vascular evaluations in preoperative living liver donors: comparison with gadobenate dimeglumine-enhanced MRI
    Myoung Seok Lee
    Department of Radiology, Seoul National University Hospital, Seoul, Korea
    J Magn Reson Imaging 33:149-59. 2011
    ..To compare gadoxetic acid disodium (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) with gadobenate dimeglumine (Gd-BOPTA)-enhanced MRI in preoperative living liver donors for the evaluation of vascular and biliary variations...
  40. ncbi Quantifying differences in hepatic uptake of the liver specific contrast agents Gd-EOB-DTPA and Gd-BOPTA: a pilot study
    O Dahlqvist Leinhard
    Center for Medical Image Science and Visualization CMIV, Linkoping University, SE 58185, Linkoping, Sweden
    Eur Radiol 22:642-53. 2012
    ..To develop and evaluate a procedure for quantifying the hepatocyte-specific uptake of Gd-BOPTA and Gd-EOB-DTPA using dynamic contrast-enhanced (DCE) MRI...
  41. pmc Consensus report of the 4th International Forum for Gadolinium-Ethoxybenzyl-Diethylenetriamine Pentaacetic Acid Magnetic Resonance Imaging
    Jeong Min Lee
    Department of Radiology, Seoul National University College of Medicine, 101 Daehak Ro, Jongno gu, Seoul, Korea
    Korean J Radiol 12:403-15. 2011
    ..Gd-EOB-DTPA is also emerging as a promising tool for functional analysis, enabling the calculation of post-surgical liver function in the remaining segments. Updates to current algorithms were also discussed...
  42. ncbi Renal perfusion 3-T MR imaging: a comparative study of arterial spin labeling and dynamic contrast-enhanced techniques
    Wen Chau Wu
    Graduate Institute of Oncology, National Taiwan University, No 1, Sec 1, Ren Ai Rd, Taipei 100, Taiwan
    Radiology 261:845-53. 2011
    ..To investigate the feasibility of and correlation between arterial spin-labeling (ASL) and dynamic contrast material-enhanced (DCE) 3-T magnetic resonance (MR) imaging in the measurement of renal blood flow (RBF)...
  43. pmc Inflammation in carotid atherosclerotic plaque: a dynamic contrast-enhanced MR imaging study
    William S Kerwin
    Department of Radiology, Division of Cardiology, and Department of Surgery, University of Washington, 815 Mercer St, Seattle, WA 98109, USA
    Radiology 241:459-68. 2006
    ..To prospectively evaluate if there is an association between plaque enhancement at magnetic resonance (MR) imaging and proinflammatory cardiovascular risk factors and plaque content...
  44. ncbi New proposal for the staging of nonalcoholic steatohepatitis: evaluation of liver fibrosis on Gd-EOB-DTPA-enhanced MRI
    Natsuko Tsuda
    Medical Affairs Diagnostic Imaging, Medical Affairs, Bayer Yakuhin, Ltd 2 4 9, Umeda, Kita ku, Osaka 530 0001, Japan
    Eur J Radiol 73:137-42. 2010
    ..We investigated whether the gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI was useful for nonalcoholic steatohepatitis (NASH) staging based on the severity of liver fibrosis...
  45. pmc Reproducibility of CT perfusion parameters in liver tumors and normal liver
    Chaan S Ng
    Department of Diagnostic Radiology, University of Texas M D Anderson Cancer Center, 1400 Pressler St, Unit 1473, Houston, TX 77030 4009, USA
    Radiology 260:762-70. 2011
    ..To assess the reproducibility of computed tomographic (CT) perfusion measurements in liver tumors and normal liver and effects of motion and data acquisition time on parameters...
  46. ncbi Three-dimensional delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at 1.5T and 3.0T
    Charles A McKenzie
    Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Magn Reson Imaging 24:928-33. 2006
    ..5T and 3.0T...
  47. ncbi Quantification of renal perfusion: comparison of arterial spin labeling and dynamic contrast-enhanced MRI
    Jeff D Winter
    Research Institute, Diagnostic Imaging, Hospital for Sick Children, Toronto, Canada
    J Magn Reson Imaging 34:608-15. 2011
    ..Moreover, we provide the first application of the dual bolus approach to quantitative DCE-MRI perfusion measurements in the kidney...
  48. pmc Optimal k-space sampling for dynamic contrast-enhanced MRI with an application to MR renography
    Ting Song
    Department of Radiology, New York University School of Medicine, New York, New York 10016, USA
    Magn Reson Med 61:1242-8. 2009
    ..4 sec temporal resolution. The proposed method can be generalized to other dynamic contrast-enhanced MRI applications, e.g., MR angiography or cancer imaging...
  49. ncbi Hepatocellular carcinoma: imaging patterns on gadoxetic acid-enhanced MR Images and their value as an imaging biomarker
    Jin Woo Choi
    Department of Radiology, Seoul National University College of Medicine, 101 Daehangno, Jongno gu, Seoul 110 744, Korea
    Radiology 267:776-86. 2013
    ....
  50. pmc Combining diffusion-weighted MRI with Gd-EOB-DTPA-enhanced MRI improves the detection of colorectal liver metastases
    D M Koh
    Department of Radiology, Royal Marsden NHS Foundation Trust, Sutton, UK
    Br J Radiol 85:980-9. 2012
    ....
  51. ncbi Dynamic contrast-enhanced magnetic resonance imaging of abdominal solid organ and major vessel: comparison of enhancement effect between Gd-EOB-DTPA and Gd-DTPA
    Tsutomu Tamada
    Department of Radiology, Kawasaki Medical School, Okayama, Japan
    J Magn Reson Imaging 29:636-40. 2009
    ....
  52. ncbi Detection of pancreatic carcinoma and liver metastases with gadoxetic acid-enhanced MR imaging: comparison with contrast-enhanced multi-detector row CT
    Utaroh Motosugi
    Department of Radiology, University of Yamanashi, 1110 Shimokato, Chuo shi, Yamanashi 409 3898, Japan
    Radiology 260:446-53. 2011
    ..To intraindividually compare gadoxetic acid-enhanced magnetic resonance (MR) imaging with contrast material-enhanced multi-detector row computed tomography (CT) in detection of pancreatic carcinoma and liver metastases...
  53. ncbi Phase-sensitive inversion-recovery MR imaging in the detection of myocardial infarction
    Armin M Huber
    Institute for Clinical Radiology, Clinic of Ludwig Maximilians University Munich, Grosshadern, Marchioninistr 15, 81377 Munich, Germany
    Radiology 237:854-60. 2005
    ....
  54. ncbi Diagnosis of colorectal hepatic metastases: comparison of contrast-enhanced CT, contrast-enhanced US, superparamagnetic iron oxide-enhanced MRI, and gadoxetic acid-enhanced MRI
    Ali Muhi
    Department of Radiology, University of Yamanashi, Yamanshi, Japan
    J Magn Reson Imaging 34:326-35. 2011
    ....
  55. ncbi Hemorrhage detection during focused-ultrasound induced blood-brain-barrier opening by using susceptibility-weighted magnetic resonance imaging
    Hao Li Liu
    Department of Electrical Engineering, Chang Gung University, Linkou, Taiwan
    Ultrasound Med Biol 34:598-606. 2008
    ..Potential applications such as drug delivery in the brain might be benefited...
  56. ncbi Effect of left ventricular scar size, location, and transmurality on left ventricular remodeling with healed myocardial infarction
    Stein Orn
    University of Bergen, Stavanger University Hospital, Stavanger, Norway
    Am J Cardiol 99:1109-14. 2007
    ..In conclusion, in the studied cohort, there was a linear relation between scar size and ejection fraction and LV volumes. This relation was independent of scar location and transmurality...
  57. ncbi Distinguishing hypervascular pseudolesions of the liver from hypervascular hepatocellular carcinomas with gadoxetic acid-enhanced MR imaging
    Utaroh Motosugi
    Department of Radiology, University of Yamanashi, Chuo shi, Yamanashi, Japan
    Radiology 256:151-8. 2010
    ....
  58. ncbi Intraindividual comparison of gadoxetate disodium-enhanced MR imaging and 64-section multidetector CT in the Detection of hepatocellular carcinoma in patients with cirrhosis
    Michele Di Martino
    Departments of Radiological Sciences, General Surgery, Division of Organ Transplantation, Surgery P Valdoni, and Statistics, University of Rome Sapienza, Rome, Italy
    Radiology 256:806-16. 2010
    ..To prospectively compare gadoxetate disodium-enhanced magnetic resonance (MR) imaging with multiphasic 64-section multidetector computed tomography (CT) in the detection of hepatocellular carcinoma (HCC) in patients with cirrhosis...
  59. pmc Prediction of global left ventricular functional recovery in patients with heart failure undergoing surgical revascularisation, based on late gadolinium enhancement cardiovascular magnetic resonance
    Tammy J Pegg
    University of Oxford Centre for Clinical Magnetic Resonance Research, UK
    J Cardiovasc Magn Reson 12:56. 2010
    ..Finally, we examined which segmental transmural threshold of scarring best predicted global LV recovery...
  60. ncbi Contrast-enhanced MR cholangiography with Gd-EOB-DTPA in patients with liver cirrhosis: visualization of the biliary ducts in comparison with patients with normal liver parenchyma
    Frank T C Tschirch
    Institute of Diagnostic Radiology, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    Eur Radiol 18:1577-86. 2008
    ..Consecutively, EOB-MRC in patients with liver cirrhosis resulted in a decreased or even non-visualization of the biliary tree in a substantial percentage of patients...
  61. ncbi Quantifying spatial heterogeneity in dynamic contrast-enhanced MRI parameter maps
    Chris J Rose
    School of Medicine, The University of Manchester, Manchester, United Kingdom
    Magn Reson Med 62:488-99. 2009
    ..An experiment using 23 DCE-MRI parameter maps of gliomas-a class of tumour that is graded on the basis of heterogeneity-shows that the proposed heterogeneity biomarkers are able to differentiate between low- and high-grade tumours...
  62. ncbi Focal disruption of the blood-brain barrier due to 260-kHz ultrasound bursts: a method for molecular imaging and targeted drug delivery
    Kullervo Hynynen
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts
    J Neurosurg 105:445-54. 2006
    ....
  63. ncbi Qualitative and quantitative evaluation of hepatocellular carcinoma and cirrhotic liver enhancement using Gd-EOB-DTPA
    Bernd B Frericks
    Department of Radiology and Nuclear Medicine, Charite Campus Benjamin Franklin, Universitatsmedizin Berlin, Hindenburgdamm 30, 12200 Berlin, Germany
    AJR Am J Roentgenol 193:1053-60. 2009
    ....
  64. ncbi Evaluation of the accuracy of gadolinium-enhanced cardiovascular magnetic resonance in the diagnosis of cardiac sarcoidosis
    Jan Peter Smedema
    Department of Cardiology, University Hospital Maastricht, Maastricht, The Netherlands
    J Am Coll Cardiol 45:1683-90. 2005
    ..This study analyzed the accuracy of gadolinium-enhanced cardiovascular magnetic resonance (CMR) for the diagnosis of cardiac sarcoidosis (CS)...
  65. ncbi Assessment of diffuse myocardial fibrosis in rats using small-animal Look-Locker inversion recovery T1 mapping
    Daniel R Messroghli
    Department of Congenital Heart Disease and Pediatric Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany
    Circ Cardiovasc Imaging 4:636-40. 2011
    ..We hypothesized that diffuse myocardial fibrosis in a small-animal model could be quantitatively assessed by measuring myocardial ECV using small-animal Look-Locker inversion recovery T1 mapping...
  66. ncbi Hepatobiliary-specific MR contrast agents: role in imaging the liver and biliary tree
    Melanie K Seale
    Division of Abdominal Imaging and Intervention, Massachusetts General Hospital, White 270, 55 Fruit St, Boston, MA 02114, USA
    Radiographics 29:1725-48. 2009
    ..In the future, hepatobiliary-specific contrast agents may have wider applications, such as grading of cirrhosis and quantification of liver function...
  67. ncbi Diagnostic performance and description of morphological features of focal nodular hyperplasia in Gd-EOB-DTPA-enhanced liver magnetic resonance imaging: results of a multicenter trial
    Christoph J Zech
    Institute of Clinical Radiology, University Hospital Munich Grosshadern, Ludwig Maximilians University Munich, Munich, Germany
    Invest Radiol 43:504-11. 2008
    ....
  68. pmc Magnetic resonance imaging delineates the ischemic area at risk and myocardial salvage in patients with acute myocardial infarction
    Colin Berry
    Department of Health and Human Services, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1061, USA
    Circ Cardiovasc Imaging 3:527-35. 2010
    ..The area at risk (AAR) is a key determinant of myocardial infarction (MI) size. We investigated whether magnetic resonance imaging (MRI) measurement of AAR would be correlated with an angiographic AAR risk score in patients with acute MI...
  69. ncbi Cardiac magnetic resonance monitors reversible and irreversible myocardial injury in myocarditis
    Anja Zagrosek
    Franz Volhard Klinik, Kardiologie, Charite Campus Buch, HELIOS Klinikum Berlin, Universitatsmedizin Berlin, Berlin, Germany
    JACC Cardiovasc Imaging 2:131-8. 2009
    ..We sought to assess the value of cardiac magnetic resonance (CMR) to monitor the spectrum of myocarditis-related injuries over the course of the disease...
  70. ncbi Experimentally-derived functional form for a population-averaged high-temporal-resolution arterial input function for dynamic contrast-enhanced MRI
    Geoff J M Parker
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK
    Magn Reson Med 56:993-1000. 2006
    ....
  71. ncbi Hepatocellular carcinoma: signal intensity at gadoxetic acid-enhanced MR Imaging--correlation with molecular transporters and histopathologic features
    Azusa Kitao
    Department of Radiology, Human Pathology, and Gastroenterology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa 920 8640, Japan
    Radiology 256:817-26. 2010
    ....
  72. ncbi MR imaging of adventitial vasa vasorum in carotid atherosclerosis
    W S Kerwin
    Department of Radiology, University of Washington, Seattle, Washington, USA
    Magn Reson Med 59:507-14. 2008
    ..141 +/- 0.036 vs. 0.111 +/- 0.017 min(-1); P = 0.02). Because these factors are all associated with higher risk of atherosclerotic complications, these results suggest that adventitial K(trans) may be a marker of risk as well...
  73. ncbi Gadolinium-enhanced magnetic resonance imaging for detection and quantification of fibrosis in human myocardium in vitro
    Elizabeth Kehr
    Cardiac Arrhythmia Center, Division of Cardiovascular Medicine, UHN 62, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Int J Cardiovasc Imaging 24:61-8. 2008
    ....
  74. ncbi Gadoxetic acid-enhanced MRI versus triple-phase MDCT for the preoperative detection of hepatocellular carcinoma
    Seong Hyun Kim
    Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    AJR Am J Roentgenol 192:1675-81. 2009
    ..We compared the diagnostic performance of gadoxetic acid-enhanced MRI with that of triple-phase 16-, 40-, and 64-MDCT in the preoperative detection of hepatocellular carcinoma (HCC)...
  75. ncbi Improved detection of focal liver lesions at MR imaging: multicenter comparison of gadoxetic acid-enhanced MR images with intraoperative findings
    Alexander Huppertz
    Institute of Clinical Radiology, Klinikum Grosshadern, University of Munich, Germany
    Radiology 230:266-75. 2004
    ....
  76. ncbi The salvaged area at risk in reperfused acute myocardial infarction as visualized by cardiovascular magnetic resonance
    Matthias G Friedrich
    Stephenson Cardiovascular Magnetic Resonance Centre at the Libin Cardiovascular Institute of Alberta, Department of Cardiac Sciences, University of Calgary, Alberta, Canada
    J Am Coll Cardiol 51:1581-7. 2008
    ..We aimed to characterize the tissue changes within the perfusion bed of infarct-related vessels in patients with acutely reperfused myocardial infarction (MI) using cardiovascular magnetic resonance (CMR)...
  77. pmc Rapid assessment of myocardial infarct size in rodents using multi-slice inversion recovery late gadolinium enhancement CMR at 9.4T
    Anthony N Price
    UCL Centre for Advanced Biomedical Imaging, Department of Medicine and UCL Institute of Child Health, University College London, Medical School, and The Hatter Cardiovascular Institute, University College London Hospital, UK
    J Cardiovasc Magn Reson 13:44. 2011
    ..Applying such methods to small animals is challenging due to rapid respiratory and cardiac rates relative to T1 relaxation...
  78. pmc Discrimination of benign and malignant breast lesions by using shutter-speed dynamic contrast-enhanced MR imaging
    Wei Huang
    W M Keck Foundation High Field MRI Laboratory Advanced Imaging Research Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    Radiology 261:394-403. 2011
    ..To assess the accuracy of the shutter-speed approach compared with standard approach dynamic contrast material-enhanced magnetic resonance (MR) imaging pharmacokinetic analysis for breast cancer diagnosis...
  79. ncbi Comparison of the iron oxide-based blood-pool contrast medium VSOP-C184 with gadopentetate dimeglumine for first-pass magnetic resonance angiography of the aorta and renal arteries in pigs
    Jorg Schnorr
    Department of Radiology, Charite Universitatsmedizin Berlin, Germany
    Invest Radiol 39:546-53. 2004
    ..The present study was performed to determine whether VSOP-C184 is also suitable for first-pass MRA...
  80. ncbi Multifunctional gadolinium-based dendritic macromolecules as liver targeting imaging probes
    Kui Luo
    National Engineering Research Center for Biomaterials, Sichuan University, 29 Wangjiang Road, Chengdu 610064, China
    Biomaterials 32:2575-85. 2011
    ..The design strategy of multifunctional Gd-ligand peptide dendritic macromolecules in this study may be used for developing other sensitive MRI probes with targeting capability...
  81. ncbi Pixel-by-pixel analysis of DCE MRI curve patterns and an illustration of its application to the imaging of the musculoskeletal system
    Cristina Lavini
    Department of Radiology, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
    Magn Reson Imaging 25:604-12. 2007
    ....
  82. ncbi Dual-bolus approach to quantitative measurement of pulmonary perfusion by contrast-enhanced MRI
    Frank Risse
    Department of Medical Physics in Radiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Magn Reson Imaging 24:1284-90. 2006
    ..To evaluate a dual-bolus approach to pulmonary perfusion MRI...
  83. ncbi Biliary MR imaging with Gd-EOB-DTPA and its clinical applications
    Nam Kyung Lee
    Department of Radiology, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Pusan National University, 1 10 Ami dong, Seo Gu, Busan 602 739, Republic of Korea
    Radiographics 29:1707-24. 2009
    ..However, the clinical applications of this imaging technique have not yet been fully explored, and further investigations are needed to determine the utility of Gd-EOB-DTPA-enhanced MR cholangiography in a clinical setting...
  84. ncbi Dynamic contrast-enhanced magnetic resonance imaging of tumor interstitial fluid pressure
    Kristine Gulliksrud
    Department of Radiation Biology, Institute for Cancer Research, Oslo, Norway
    Radiother Oncol 91:107-13. 2009
    ..The potential usefulness of gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA)-based dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for assessing tumor IFP noninvasively was investigated in the present study...
  85. ncbi Gd-EOB-DTPA-enhanced 3.0 T MR imaging: quantitative and qualitative comparison of hepatocyte-phase images obtained 10 min and 20 min after injection for the detection of liver metastases from colorectal carcinoma
    Keitaro Sofue
    Division of Diagnostic Radiology, National Cancer Center Hospital, 5 1 1, Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Eur Radiol 21:2336-43. 2011
    ..0 T MR imaging...
  86. ncbi Gadoxetate disodium-enhanced magnetic resonance imaging versus contrast-enhanced 18F-fluorodeoxyglucose positron emission tomography/computed tomography for the detection of colorectal liver metastases
    Hyo Jung Seo
    Division of Nuclear Medicine, Department of Radiology, Yonsei University Health System, Seoul, Republic of Korea
    Invest Radiol 46:548-55. 2011
    ....
  87. ncbi Reproducibility of imaging human knee cartilage by delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at 1.5 Tesla
    J Multanen
    Department of Health Sciences, University of Jyvaskyla, Jyvaskyla, Finland
    Osteoarthritis Cartilage 17:559-64. 2009
    ..The purpose of this study was to investigate the day-to-day reproducibility of the delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) measurement at different knee joint surfaces in healthy subjects at 1.5 Tesla (T)...
  88. pmc Induction of the expression of profibrotic cytokines and growth factors in normal human peripheral blood monocytes by gadolinium contrast agents
    Peter J Wermuth
    Thomas Jefferson University, Jefferson Institute of Molecular Medicine, Philadelphia, Pennsylvania 19107, USA
    Arthritis Rheum 60:1508-18. 2009
    ....
  89. pmc The kinetics of blood brain barrier permeability and targeted doxorubicin delivery into brain induced by focused ultrasound
    Juyoung Park
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Ave Boston, MA 02115, USA
    J Control Release 162:134-42. 2012
    ..The results of this study provide information needed to take into account the dynamics BBB disruption over time after FUS...
  90. ncbi The histological basis of late gadolinium enhancement cardiovascular magnetic resonance in a patient with Anderson-Fabry disease
    James C Moon
    CMR Unit, Royal Brompton Hospital, London, United Kingdom
    J Cardiovasc Magn Reson 8:479-82. 2006
    ..This scarring may be the substrate for electrical re-entry and sudden arrhythmic death. The reasons for this distribution of fibrosis are unclear, but may reflect inhomogeneous left ventricular wall stress...
  91. ncbi Preoperative detection of colorectal liver metastases in fatty liver: MDCT or MRI?
    Vanessa Kulemann
    Department of Radiology, Medical University of Vienna, Austria
    Eur J Radiol 79:e1-6. 2011
    ....
  92. ncbi Single breath-hold assessment of ventricular volumes using 32-channel coil technology and an extracellular contrast agent
    Victoria Parish
    Division of Imaging Sciences, NIHR Biomedical Research Centre at Guy s and St Thomas NHS Foundation Trust, King s College London, London, UK
    J Magn Reson Imaging 31:838-44. 2010
    ..To evaluate the feasibility of a single breath-hold 3D cine balanced steady-state free precession (b-SSFP) sequence after gadolinium diethylenetriamine penta-acetic acid (Gd-DTPA) injection for volumetric cardiac assessment...
  93. ncbi Gadolinium-conjugated PLA-PEG nanoparticles as liver targeted molecular MRI contrast agent
    Zhijin Chen
    School of Pharmaceutical Science, Shandong University, Ji Nan, People s Republic of China
    J Drug Target 19:657-65. 2011
    ..57 comparing with Magnevist injection. Therefore, the Gd-labeled nanoparticles showed the potential as targeting molecular MRI contrast agent for further clinical utilization...
  94. pmc T1 Mapping in cardiomyopathy at cardiac MR: comparison with endomyocardial biopsy
    Christopher T Sibley
    Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering, Department of Health and Human Services, 10 Center Dr, Building 10, MSC 1182, Bethesda, MD 20892 1182, USA
    Radiology 265:724-32. 2012
    ..To determine the utility of cardiac magnetic resonance (MR) T1 mapping for quantification of diffuse myocardial fibrosis compared with the standard of endomyocardial biopsy...
  95. ncbi Diffusion-weighted MR imaging of liver on 3.0-Tesla system: effect of intravenous administration of gadoxetic acid disodium
    Ji Soo Choi
    Department of Radiology, Severance Hospital and Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea
    Eur Radiol 20:1052-60. 2010
    ..0 t...
  96. ncbi Comparison of gadoxetic acid-enhanced dynamic imaging and diffusion-weighted imaging for the preoperative evaluation of colorectal liver metastases
    Woo Suk Chung
    Department of Diagnostic Radiology, Institute of Gastroenterology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
    J Magn Reson Imaging 34:345-53. 2011
    ..0 Tesla (T) system, and then to determine whether a combination of the two techniques may improve the diagnostic performance...
  97. ncbi Planning transarterial radioembolization of colorectal liver metastases with Yttrium 90 microspheres: evaluation of a sequential diagnostic approach using radiologic and nuclear medicine imaging techniques
    Timm Denecke
    Klinik fur Strahlenheilkunde, Bereiche Radiologie und Nuklearmedizin, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Eur Radiol 18:892-902. 2008
    ..Each part of the diagnostic algorithm showed a relevant impact on patient management. The sequential approach appears to be suitable and keeps the number of unnecessary treatments and therapy risks to a minimum...
  98. ncbi Gadoxetate disodium-enhanced MRI of the liver: part 1, protocol optimization and lesion appearance in the noncirrhotic liver
    Kristina I Ringe
    Department of Radiology, Duke University Medical School, Durham, NC 27710, USA
    AJR Am J Roentgenol 195:13-28. 2010
    ....
  99. ncbi Comparison of arterial spin labeling and first-pass dynamic contrast-enhanced MR imaging in the assessment of pulmonary perfusion in humans: the inflow spin-tracer saturation effect
    Yi Ru Lin
    Department of Electrical Engineering, National Taiwan University, Taipei, Republic of China
    Magn Reson Med 52:1291-301. 2004
    ....
  100. pmc Blood-brain barrier: real-time feedback-controlled focused ultrasound disruption by using an acoustic emissions-based controller
    Meaghan A O'Reilly
    Physical Science Platform, Sunnybrook Research Institute, Toronto, ON, Canada M4N 3M5
    Radiology 263:96-106. 2012
    ..To determine if focused ultrasound disruption of the blood-brain barrier (BBB) can be safely controlled by using real-time modulation of treatment pressures on the basis of acoustic emissions from the exposed microbubbles...
  101. ncbi Myocardial delayed enhancement in patients with pulmonary hypertension and right ventricular failure: evaluation by cardiac MRI
    F P Junqueira
    Clinica de Diagnostico por Imagem, Av das Américas 4666 sala 325, Barra da Tijuca, Rio de Janeiro RJ, Brazil
    Br J Radiol 82:821-6. 2009
    ..We found that septal MDE can be present in patients with PAH and impaired ventricular function. However, further studies are necessary to investigate this possible association and its prognostic implication...

Research Grants67

  1. Targeted Photoactivable Nanocells: Image-based Drug Delivery and Dosimetry in GBM
    Brian W Pogue; Fiscal Year: 2013
    ..Quantitative imaging will also accelerate fluorescence-guided resections for GBM already in advanced clinical trials. Finally, the approach developed here will be adaptable to treating a broad range of diseases. ..
  2. Vascular breakdown in Alzheimers Disease with cerebrovascular disease
    Donna M Wilcock; Fiscal Year: 2013
    ..We believe that CBVD is common co- morbidity with AD that influences the pathogenesis of AD and response to therapy. ..
  3. MR-Guided Endovascular Intervention Using Off-Resonance Contrast Angiography
    Robert R Edelman; Fiscal Year: 2010
    ..This study will result in a better understanding of the basic contrast mechanisms and will lead to improved treatment strategies for renovascular hypertension using MR-guided interventional procedures. ..
  4. FEASIBILITY OF OVERHAUSER-ENHANCED MR MAMMOGRAPHY
    James Lee; Fiscal Year: 1993
    ..This will determine the feasibility of using Overhauser enhanced imaging for breast cancer detection, and indicate the degree of field reduction that produces optimum results...
  5. MRI OF RENAL ANATOMY AND FUNCTION IN CHRONIC ISCHEMIA
    Frank Sommer; Fiscal Year: 2002
    ..The utility of the comprehensive exam will be determined by correlating pre- intervention MRI-determined parameters with both clinical outcome measures and post-intervention MRI-determined parameters. ..
  6. PREDICTING HUMAN TUMOR RESPONSE BY 31P MRS
    HAL CHARLES; Fiscal Year: 1999
    ..The working hypotheses are that pretherapy and proximal posththerapy 31-P MRS metabolite levels, pH, and t2 values will be prognostic of treatment outcome. ..
  7. MRI Quantification of Postinfarct Myocardial Viability
    PAL SURANYI; Fiscal Year: 2005
    ..TTC perfusion of the same dogs as above will be carried out at the end of the MRI session and heart will be immediately excised for histology, to ensure comparison with the in vivo results at the same time point. ..
  8. In vivo Image Guided Cancer Therapy
    Anna Moore; Fiscal Year: 2007
    ..If successful, this study can further be translated into clinical applications, since related iron oxides have already been tested in clinical trials. [unreadable] [unreadable] [unreadable]..
  9. Aerosolized PGE1 in Neonatal Pulmonary Hypertension
    BEENA SOOD; Fiscal Year: 2005
    ..If effective, a proposal for using aerosolized PGE1 in neonatal PPHN as a multicenter study will be submitted to the NICHD Neonatal Network. ..
  10. REGIONAL BETA ADRENERGIC DURING LV REMODELING
    Christopher Kramer; Fiscal Year: 2002
    ..Effects of beta-blockade on regional cell morphometry, collagen content, and blood flow will be assessed using isolated myocytes, quantitative histopathology, and fluorescent microspheres, respectively. ..
  11. MRI of Acute Vascular Injury and Hemorrhagic Transformation in Ischemic Stroke
    Robert A Knight; Fiscal Year: 2010
    ..e., BBB opening) and both will be functions of the variations in BBB associated proteins and/or brain swelling;and 2) the size of these changes are correlated over time, ROI, and treatment. ..
  12. MYOCARDIAL PERFUSION, RISK FACTORS, AND CORONARY CALCIUM
    Michael Jerosch Herold; Fiscal Year: 2003
    ..S. there is strong interest in developing such new measures of subclinical disease which would provide an early opportunity for intervention and lifestyle modification to prevent CHD and/or congestive heart failure. ..
  13. Comprehensive Magnetic Resonance in PAD
    Christopher Kramer; Fiscal Year: 2008
    ..Improving the health outcomes and quality of life in patients with PAD is a major goal of this proposal. ..
  14. MR Guided Transendocardial Angiogenic Agents
    Maythem Saeed; Fiscal Year: 2007
    ..abstract_text> ..
  15. Multiparametric MRI characterization of breast tissue
    Michael Jacobs; Fiscal Year: 2009
    ..abstract_text> ..
  16. A Seven Tesla MRI System for Small Animals MRI/MRS
    Robert Knight; Fiscal Year: 2007
    ..This Shared Instrumentation Grant will partially supply the funds to bring the present MRI/MRS system up to current standards, with HFHS supplying the rest. [unreadable] [unreadable] [unreadable]..
  17. NMR STUDIES OF HEMORRHAGIC TRANSFORMATION IN ISCHEMIA
    Robert Knight; Fiscal Year: 2002
    ....
  18. MRI Quantification & Display of Hepatic Fat in Hepatitis C & NAFLD Patients
    Hero Hussain; Fiscal Year: 2008
    ..We are proposing to explore whether a non-invasive imaging technique (magnetic resonance spectroscopy) can be used to provide a more accurate and informative method to study these patients. [unreadable] [unreadable] [unreadable]..
  19. Combined MRI and Optical Imaging to Improved Breast Cancer Diagnosis
    Min Ying Su; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  20. Iron and Atherosclerosis
    Subha Raman; Fiscal Year: 2006
    ..Subgroup analyses will include comparison of the presence of iron symptomatic versus asymptomatic patients and women versus age-matched men. ..
  21. Measurement of Absolute Cerebral Blood Volume using Magnetic Resonance Imaging
    Hanzhang Lu; Fiscal Year: 2008
    ..In this project, a new technique will be developed to measure CBV in human brain using MRI. [unreadable] [unreadable] [unreadable]..
  22. Development of Direct Metabolite Imaging for Human Breast Cancer
    Jiani Hu; Fiscal Year: 2008
    ..If successful, it should become part of the routine clinical breast MRI exams, and thereby reduce the high incidence of false positive MRI and associated anxiety, risk and cost of benign biopsies. [unreadable] [unreadable] [unreadable]..
  23. A LONGITUDINAL STUDY IN THE CANINE MODEL OF HUMAN AGING
    Min Ying Su; Fiscal Year: 2005
    ..Noninvasive MR imaging techniques may offer a means of detecting early signs of pathological aging, allowing us the opportunity to initiate interventions to slow disease progression. ..
  24. Paramagnetic Enhancement in Off-Resonance Rotating Frame
    Huiming Zhang; Fiscal Year: 2004
    ..We will generalize a method for assessing the quantity and environment of a paramagnetic probe required in specific application such as imaging drug delivery, cell migration and tumor growth. ..
  25. Susceptibility Weighted Imaging (SWI)
    EWART MARK HAACKE; Fiscal Year: 2010
    ..Recently, SWI has also become available to the clinical world for every day use and therefore its continued technical development is of paramount importance for the proper diagnosis of these diseases in patients. ..
  26. Smash Contrast-Enhanced 3D MR Angiography
    Robert Edelman; Fiscal Year: 2002
    ....
  27. Smash Contrast-Enhanced 3D MR Angiography
    Robert Edelman; Fiscal Year: 2003
    ....
  28. Evaluation of New Imaging Methodologies at 7T
    EWART HAACKE; Fiscal Year: 2007
    ..Many of the approaches developed and applied on this animal system are expected to have important clinical impact. All of these projects will substantially benefit from the proposed acquisition. [unreadable] [unreadable] [unreadable]..
  29. BREATH HOLD 3D MRA OF THE CORONARY ARTERIES
    Robert Edelman; Fiscal Year: 2002
    ..The goal is to optimize the MRA method and to determine if the use of contrast agents provides any clinical benefit. ..
  30. Opening of the Blood Brain Barrier to Antitumor Agents
    Edward Neuwelt; Fiscal Year: 2008
    ..This revised competitive renewal is the continuation of the original 1978 surgical CREG, and is responsive to the priorities established in July 2000 by the joint NINDS and NCI Brain Tumor PRG. ..
  31. Tissue Characterization with Diffusion MRI
    Stephan Maier; Fiscal Year: 2009
    ..MR diffusion imaging is widely used for medical diagnosis and is rapidly exploring new indications. This study, therefore, proposes basic research, which will improve the interpretation of clinical MR diffusion image data. ..
  32. Trial of Vitamin D to Reduce Progression of Knee OA
    Timothy McAlindon; Fiscal Year: 2008
    ..We will test effectiveness of vitamin D using cross-sectional time series regression models with first-order autoregressive disturbance adjusting for informative dropouts. ..
  33. MRI MONITORING OF ANGIOGENESIS INHIBITION
    ROBERT BRASCH; Fiscal Year: 2008
    ....
  34. Redox-Sensitive & Blood-pool Contrast Agents for Magnetic Resonance Imaging
    Natarajan Raghunand; Fiscal Year: 2010
    ..The overall goal of this application is to develop Magnetic Resonance Iaging biomarm kers of pathologically significant characteristics of tumors, to aid in the selection of, and non-invasively follow response to, targeted therapies. ..
  35. The Cardiac Atlas Project: Establishment of a Cardiac MRI Database.
    ALISTAIR ANDREW YOUNG; Fiscal Year: 2010
    ..By pooling data from many studies into a single resource, researchers will be able to perform standardized comparisons across many patient groups, in order to better predict and evaluate the effects of disease and treatment. ..
  36. Model-Based Reconstruction for Dynamic MRI
    EDWARD VR DI BELLA; Fiscal Year: 2010
    ..The proposed approach can be extended to improve non-cardiac dynamic MRI applications such as studies of the response of tumors to therapy and the response of the brain to stimuli. ..
  37. MR Dynamic Imaging and Spectroscopy in Head & Neck Cancers
    AMITA DAVE; Fiscal Year: 2010
    ..If successful, it will provide an a priori predictor of failure/response to chemotherapy and/or long term disease free-survival, resulting in patient specific treatment which will likely enhance outcome. ..
  38. MRI AND MRS OF HORMONAL INDUCED CHANGES IN BREAST CANCER
    Hadassa Degani; Fiscal Year: 2008
    ..This, in turn, may improve significantly the assessment of prognosis and the management of the approximate 75% of the breast cancer patients with ER-positive tumors. ..
  39. 13C and 15N MRS Study of glutamate control in epilepsy
    Brian Ross; Fiscal Year: 2009
    ..Together these studies will contribute to a better understanding of the regulatory events of the GLN/GLU cycle in KA and increase potential to replace surgical management of temporal lobe epilepsy. ..
  40. Adhesion signaling by a novel mitotic substrate of src
    Mark Moasser; Fiscal Year: 2009
    ..abstract_text> ..
  41. Quantitative MRI Assessment of Tumor Vascular and Oxygen Reactivity
    CHRISTOPHER QUARLES; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  42. Opening of the Blood Brain Barrier for Molecular Imaging
    Kullervo Hynynen; Fiscal Year: 2007
    ..The development of even one such imaging method for routine clinical use would have a major impact on patient care. [unreadable] [unreadable]..
  43. MR STUDIES OF EXPERIMENTAL RETINOPATHY OF PREMATURITY
    BRUCE BERKOWITZ; Fiscal Year: 2001
    ..This work may have broad impact beyond ROP since abnormal blood vessel growth is a common pathobiologic event for other blinding disorders, such as diabetic retinopathy. ..
  44. MICROVASC OBSTRUCTION BY MRI AFTER CORONARY INTERVENTION
    Katherine Wu; Fiscal Year: 2004
    ..abstract_text> ..
  45. MENTORED PATIENT ORIENTED RESEARCH CAREER DEVELOPMENT AW
    John Sampson; Fiscal Year: 2004
    ....
  46. fMRI Studies of Retinal Oxygenation in Diabetic Patients
    Gary Trick; Fiscal Year: 2004
    ..The results of this proposed study may aid in the early diagnosis and staging of diabetic retinopathy as well as in the development and application of rational prevention and treatment strategies. ..
  47. COMPREHENSIVE MR EVALUATION OF RENOVASCULAR DISEASE
    Vivian Lee; Fiscal Year: 2003
    ....
  48. Magnetic Resonance Renography:Validation Studies
    Vivian Lee; Fiscal Year: 2003
    ..abstract_text> ..
  49. TISSUE CHARACTERIZATION WITH SLAB SCAN DIFFUSIION MRI
    Stephan Maier; Fiscal Year: 2002
    ..The study, therefore, proposes direct applications of basic research to clinical situations demanding the highest possible sensitivity and specific for invasive treatment of other therapeutic decisions. ..
  50. HIGH TEMPERATURE ULTRASOUND THERAPY GUIDED BY MRI
    Kullervo Hynynen; Fiscal Year: 2002
    ..The noninvasive focused ultrasound coagulation of liver tumors has a large clinical potential in reducing complication rates and costs associated with open surgery. ..
  51. ULTRASOUND THERAPY DELIVERY THROUGH INTACT SKULL
    Kullervo Hynynen; Fiscal Year: 2002
    ..A successful implementation of even one of these possible therapies to routing clinical practice could have a major impact on patient care. ..
  52. FEASIBILITY OF INTERNET-BASED TRIALS FOR OSTEOARTHRITIS
    Timothy McAlindon; Fiscal Year: 2001
    ..abstract_text> ..
  53. Magnex Model MRBR 7T/201 AS Shielded Magnet System
    Jean Philippe Galons; Fiscal Year: 2005
    ..7 Tesla platform. Therefore, the need to acquire new imaging capabilities and the growth of the UoA MRI imaging community are the main justification for the present request. ..
  54. Mechanisms of MMP-3 Action in Acute Lung Injury
    James Varani; Fiscal Year: 2005
    ..These studies will provide an overall understanding of the mechanism(s) by which MMP-3 contributes to acute lung injury. ..
  55. MRI-Guided Angioplasty of Renal Artery Stenosis
    Reed Omary; Fiscal Year: 2005
    ..MRI guidance will also avoid the ionizing radiation exposure of x-rays and the potential kidney toxicity of iodinated contrast agents. ..
  56. Novel MRI Contrast Agent for Monitoring Thermal Ablation
    Nathan Mcdannold; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  57. Biodegradable Macromolecular MRI Contrast Agents
    Zheng Rong Lu; Fiscal Year: 2006
    ..abstract_text> ..
  58. Tissue Tagging MRI of Regional Lung Mechanics
    Qun Chen; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  59. Phased Array Ultrasound System for Cardiac Ablation
    Kullervo Hynynen; Fiscal Year: 2006
    ..This could result in significant cost savings and lead to a cure of thousands of patients. ..
  60. Intracerebral Infusion of Radiolabeled Specific Antibody
    John Sampson; Fiscal Year: 2006
    ..abstract_text> ..
  61. Correlation of MRI with Cartilage Mechanical Stiffness
    Martha Gray; Fiscal Year: 2006
    ..abstract_text> ..
  62. In vivo multichannel fluorescent imaging
    Umar Mahmood; Fiscal Year: 2007
    ....
  63. Osteoarthritis following ACL reconstruction
    Braden Fleming; Fiscal Year: 2007
    ..abstract_text> ..
  64. VALIDATION OF MAGNETIC RESONANCE PERFUSION IMAGING
    Jeffry Alger; Fiscal Year: 2002
    ..UCLA has new state-of-the-art MRI and PET imaging devices together with active collaborating teams having expertise in stroke clinical management (both acute and rehabilitative), in MRI scanning and in PET scanning. ..
  65. In vivo Dynamic Imaging of Angiogenesis in Transplanted Islets
    Eba Hathout; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  66. Assessment of BBB Disruption during RT using DCE MRI
    Yue Cao; Fiscal Year: 2006
    ..Data from these scans will be analyzed to quantify vascular permeability, which related to dose, volume, time, and presence in tumor versus normal brain tissue. ..
  67. VALIDATION OF MAGNETIC RESONANCE PERFUSION IMAGING
    Jeffry Alger; Fiscal Year: 2003
    ..UCLA has new state-of-the-art MRI and PET imaging devices together with active collaborating teams having expertise in stroke clinical management (both acute and rehabilitative), in MRI scanning and in PET scanning. ..