gadolinium dtpa

Summary

Summary: A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see PENTETIC ACID), that is given to enhance the image in cranial and spinal MRIs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p706)

Top Publications

  1. ncbi The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction
    R J Kim
    Feinberg Cardiovascular Research Institute, and Department of Medicine, Northwestern University Medical School, Chicago, IL 60611 3008, USA
    N Engl J Med 343:1445-53. 2000
  2. doi Equilibrium contrast cardiovascular magnetic resonance for the measurement of diffuse myocardial fibrosis: preliminary validation in humans
    Andrew S Flett
    Department of Medicine, University College London Hospitals National Health Service Trust, The Heart Hospital, 16 18 Westmoreland St, London W1G 8PH, United Kingdom
    Circulation 122:138-44. 2010
  3. ncbi Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols
    P S Tofts
    Department of Clinical Neurology, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    J Magn Reson Imaging 10:223-32. 1999
  4. pmc Phase-sensitive inversion recovery for detecting myocardial infarction using gadolinium-delayed hyperenhancement
    Peter Kellman
    Laboratory of Cardiac Energetics, National Institutes of Health, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892 1061, USA
    Magn Reson Med 47:372-83. 2002
  5. doi Evaluation of diffuse myocardial fibrosis in heart failure with cardiac magnetic resonance contrast-enhanced T1 mapping
    Leah Iles
    Alfred Hospital and Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    J Am Coll Cardiol 52:1574-80. 2008
  6. pmc Quantification of diffuse myocardial fibrosis and its association with myocardial dysfunction in congenital heart disease
    Craig S Broberg
    Adult Congenital Heart Disease Program, Oregon Health and Science University, Portland, Ore, USA
    Circ Cardiovasc Imaging 3:727-34. 2010
  7. doi Detection and characterisation of focal liver lesions in colorectal carcinoma patients: comparison of diffusion-weighted and Gd-EOB-DTPA enhanced MR imaging
    D Lowenthal
    Department of Radiology and Nuclear Medicine, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Eur Radiol 21:832-40. 2011
  8. ncbi Optimization and validation of a fully-integrated pulse sequence for modified look-locker inversion-recovery (MOLLI) T1 mapping of the heart
    Daniel R Messroghli
    Cardiac MRI Unit, Franz Volhard Klinik, Charite Campus Buch, Universitatsmedizin Berlin, HELIOS Klinikum Berlin, Germany
    J Magn Reson Imaging 26:1081-6. 2007
  9. ncbi The histologic basis of late gadolinium enhancement cardiovascular magnetic resonance in hypertrophic cardiomyopathy
    James C C Moon
    Centre for Advanced Magnetic Resonance in Cardiology CAMRIC, London, United Kingdom
    J Am Coll Cardiol 43:2260-4. 2004
  10. ncbi Accurate and objective infarct sizing by contrast-enhanced magnetic resonance imaging in a canine myocardial infarction model
    Luciano C Amado
    Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 2187, USA
    J Am Coll Cardiol 44:2383-9. 2004

Research Grants

Detail Information

Publications241 found, 100 shown here

  1. ncbi The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction
    R J Kim
    Feinberg Cardiovascular Research Institute, and Department of Medicine, Northwestern University Medical School, Chicago, IL 60611 3008, USA
    N Engl J Med 343:1445-53. 2000
    ..We hypothesized that the results of contrast-enhanced MRI can be used to predict whether regions of abnormal ventricular contraction will improve after revascularization in patients with coronary artery disease...
  2. doi Equilibrium contrast cardiovascular magnetic resonance for the measurement of diffuse myocardial fibrosis: preliminary validation in humans
    Andrew S Flett
    Department of Medicine, University College London Hospitals National Health Service Trust, The Heart Hospital, 16 18 Westmoreland St, London W1G 8PH, United Kingdom
    Circulation 122:138-44. 2010
    ..We have developed a robust and noninvasive technique, equilibrium contrast CMR (EQ-CMR) to quantify diffuse fibrosis and have validated it against the current gold standard of surgical myocardial biopsy...
  3. ncbi Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols
    P S Tofts
    Department of Clinical Neurology, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    J Magn Reson Imaging 10:223-32. 1999
    ..We relate these quantities to previously published work from our groups; our future publications will refer to these standardized terms, and we propose that these be adopted as international standards...
  4. pmc Phase-sensitive inversion recovery for detecting myocardial infarction using gadolinium-delayed hyperenhancement
    Peter Kellman
    Laboratory of Cardiac Energetics, National Institutes of Health, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892 1061, USA
    Magn Reson Med 47:372-83. 2002
    ..Phase-sensitive detection also has the advantage of decreasing the sensitivity to changes in tissue T(1) with increasing delay from contrast agent injection...
  5. doi Evaluation of diffuse myocardial fibrosis in heart failure with cardiac magnetic resonance contrast-enhanced T1 mapping
    Leah Iles
    Alfred Hospital and Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    J Am Coll Cardiol 52:1574-80. 2008
    ..The purpose of this study was to investigate a noninvasive method for quantifying diffuse myocardial fibrosis with cardiac magnetic resonance imaging (CMRI)...
  6. pmc Quantification of diffuse myocardial fibrosis and its association with myocardial dysfunction in congenital heart disease
    Craig S Broberg
    Adult Congenital Heart Disease Program, Oregon Health and Science University, Portland, Ore, USA
    Circ Cardiovasc Imaging 3:727-34. 2010
    ..the etiology of ventricular dysfunction in adult congenital heart disease (ACHD) is not well understood. Diffuse fibrosis is a likely common final pathway and is quantifiable using MRI...
  7. doi Detection and characterisation of focal liver lesions in colorectal carcinoma patients: comparison of diffusion-weighted and Gd-EOB-DTPA enhanced MR imaging
    D Lowenthal
    Department of Radiology and Nuclear Medicine, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Eur Radiol 21:832-40. 2011
    ..To compare diffusion-weighted imaging (DWI) and Gd-EOB-DTPA-enhanced magnetic resonance (MR) imaging for the detection and characterisation of focal liver lesions (FLLs) in patients with colorectal carcinoma...
  8. ncbi Optimization and validation of a fully-integrated pulse sequence for modified look-locker inversion-recovery (MOLLI) T1 mapping of the heart
    Daniel R Messroghli
    Cardiac MRI Unit, Franz Volhard Klinik, Charite Campus Buch, Universitatsmedizin Berlin, HELIOS Klinikum Berlin, Germany
    J Magn Reson Imaging 26:1081-6. 2007
    ..To optimize and validate a fully-integrated version of modified Look-Locker inversion-recovery (MOLLI) for clinical single-breathhold cardiac T1 mapping...
  9. ncbi The histologic basis of late gadolinium enhancement cardiovascular magnetic resonance in hypertrophic cardiomyopathy
    James C C Moon
    Centre for Advanced Magnetic Resonance in Cardiology CAMRIC, London, United Kingdom
    J Am Coll Cardiol 43:2260-4. 2004
    ..We sought to identify the histologic basis of myocardial late gadolinium enhancement cardiovascular magnetic resonance (CMR) in hypertrophic cardiomyopathy (HCM)...
  10. ncbi Accurate and objective infarct sizing by contrast-enhanced magnetic resonance imaging in a canine myocardial infarction model
    Luciano C Amado
    Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 2187, USA
    J Am Coll Cardiol 44:2383-9. 2004
    ....
  11. ncbi Measurement of the gadopentetate dimeglumine partition coefficient in human myocardium in vivo: normal distribution and elevation in acute and chronic infarction
    S J Flacke
    Cardiovascular Division, Barnes-Jewish Hospital at Washington University Medical Center, St Louis, MO, USA
    Radiology 218:703-10. 2001
    ..CONCLUSION: Quantification of the lambda in vivo allows differentiation between normal and acutely or chronically infarcted myocardium, with high sensitivity and specificity...
  12. ncbi Nephrogenic systemic fibrosis: suspected causative role of gadodiamide used for contrast-enhanced magnetic resonance imaging
    Peter Marckmann
    Department of Nephrology, Copenhagen University Hospital at Herlev, DK 2730 Herlev, Denmark
    J Am Soc Nephrol 17:2359-62. 2006
    ..No other exposure/event than gadodiamide that was common to more than a minority of the patients could be identified. These findings indicate that gadodiamide plays a causative role in nephrogenic systemic fibrosis...
  13. ncbi Cardiovascular magnetic resonance in cardiac amyloidosis
    Alicia Maria Maceira
    Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, London, UK
    Circulation 111:186-93. 2005
    ..Cardiac amyloidosis can be diagnostically challenging. Cardiovascular magnetic resonance (CMR) can assess abnormal myocardial interstitium...
  14. doi Extent of left ventricular scar predicts outcomes in ischemic cardiomyopathy patients with significantly reduced systolic function: a delayed hyperenhancement cardiac magnetic resonance study
    Deborah H Kwon
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    JACC Cardiovasc Imaging 2:34-44. 2009
    ....
  15. ncbi Focal disruption of the blood-brain barrier due to 260-kHz ultrasound bursts: a method for molecular imaging and targeted drug delivery
    Kullervo Hynynen
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts
    J Neurosurg 105:445-54. 2006
    ....
  16. doi Diagnosis of colorectal hepatic metastases: comparison of contrast-enhanced CT, contrast-enhanced US, superparamagnetic iron oxide-enhanced MRI, and gadoxetic acid-enhanced MRI
    Ali Muhi
    Department of Radiology, University of Yamanashi, Yamanshi, Japan
    J Magn Reson Imaging 34:326-35. 2011
    ....
  17. doi Hemorrhage detection during focused-ultrasound induced blood-brain-barrier opening by using susceptibility-weighted magnetic resonance imaging
    Hao Li Liu
    Department of Electrical Engineering, Chang Gung University, Linkou, Taiwan
    Ultrasound Med Biol 34:598-606. 2008
    ..Potential applications such as drug delivery in the brain might be benefited...
  18. ncbi Gadolinium-enhanced magnetic resonance imaging for detection and quantification of fibrosis in human myocardium in vitro
    Elizabeth Kehr
    Cardiac Arrhythmia Center, Division of Cardiovascular Medicine, UHN 62, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Int J Cardiovasc Imaging 24:61-8. 2008
    ....
  19. ncbi Phase-sensitive inversion-recovery MR imaging in the detection of myocardial infarction
    Armin M Huber
    Institute for Clinical Radiology, Clinic of Ludwig Maximilians University Munich, Grosshadern, Marchioninistr 15, 81377 Munich, Germany
    Radiology 237:854-60. 2005
    ....
  20. ncbi Effect of left ventricular scar size, location, and transmurality on left ventricular remodeling with healed myocardial infarction
    Stein Orn
    University of Bergen, Stavanger University Hospital, Stavanger, Norway
    Am J Cardiol 99:1109-14. 2007
    ..In conclusion, in the studied cohort, there was a linear relation between scar size and ejection fraction and LV volumes. This relation was independent of scar location and transmurality...
  21. doi Intraindividual comparison of gadoxetate disodium-enhanced MR imaging and 64-section multidetector CT in the Detection of hepatocellular carcinoma in patients with cirrhosis
    Michele Di Martino
    Departments of Radiological Sciences, General Surgery, Division of Organ Transplantation, Surgery P Valdoni, and Statistics, University of Rome Sapienza, Rome, Italy
    Radiology 256:806-16. 2010
    ..To prospectively compare gadoxetate disodium-enhanced magnetic resonance (MR) imaging with multiphasic 64-section multidetector computed tomography (CT) in the detection of hepatocellular carcinoma (HCC) in patients with cirrhosis...
  22. pmc Prediction of global left ventricular functional recovery in patients with heart failure undergoing surgical revascularisation, based on late gadolinium enhancement cardiovascular magnetic resonance
    Tammy J Pegg
    University of Oxford Centre for Clinical Magnetic Resonance Research, UK
    J Cardiovasc Magn Reson 12:56. 2010
    ..Finally, we examined which segmental transmural threshold of scarring best predicted global LV recovery...
  23. doi Added value of gadoxetic acid-enhanced hepatobiliary phase MR imaging in the diagnosis of hepatocellular carcinoma
    Sung Soo Ahn
    Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Shinchon Dong 134, Seodaemun gu, Seoul 120 752, Korea
    Radiology 255:459-66. 2010
    ..To determine the added value of hepatobiliary phase images in gadoxetic acid-enhanced magnetic resonance (MR) imaging in the evaluation of hepatocellular carcinoma (HCC)...
  24. doi Distinguishing hypervascular pseudolesions of the liver from hypervascular hepatocellular carcinomas with gadoxetic acid-enhanced MR imaging
    Utaroh Motosugi
    Department of Radiology, University of Yamanashi, Chuo shi, Yamanashi, Japan
    Radiology 256:151-8. 2010
    ....
  25. ncbi Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) in early knee osteoarthritis
    Carl Johan Tiderius
    Department of Orthopedics, Diagnostic Radiology and Radiation Physics, Malmo University Hospital, Lund University, Sweden
    Magn Reson Med 49:488-92. 2003
    ..5 than at 3 hr in the diseased but not in the reference compartment. In conclusion, dGEMRIC can identify GAG loss in early stage cartilage disease with a higher sensitivity at 1.5 than 3 hr...
  26. ncbi Evaluation of the accuracy of gadolinium-enhanced cardiovascular magnetic resonance in the diagnosis of cardiac sarcoidosis
    Jan Peter Smedema
    Department of Cardiology, University Hospital Maastricht, Maastricht, The Netherlands
    J Am Coll Cardiol 45:1683-90. 2005
    ..This study analyzed the accuracy of gadolinium-enhanced cardiovascular magnetic resonance (CMR) for the diagnosis of cardiac sarcoidosis (CS)...
  27. doi Diagnostic performance and description of morphological features of focal nodular hyperplasia in Gd-EOB-DTPA-enhanced liver magnetic resonance imaging: results of a multicenter trial
    Christoph J Zech
    Institute of Clinical Radiology, University Hospital Munich Grosshadern, Ludwig Maximilians University Munich, Munich, Germany
    Invest Radiol 43:504-11. 2008
    ....
  28. ncbi Hepatobiliary-specific MR contrast agents: role in imaging the liver and biliary tree
    Melanie K Seale
    Division of Abdominal Imaging and Intervention, Massachusetts General Hospital, White 270, 55 Fruit St, Boston, MA 02114, USA
    Radiographics 29:1725-48. 2009
    ..In the future, hepatobiliary-specific contrast agents may have wider applications, such as grading of cirrhosis and quantification of liver function...
  29. doi Cardiac magnetic resonance monitors reversible and irreversible myocardial injury in myocarditis
    Anja Zagrosek
    Franz Volhard Klinik, Kardiologie, Charite Campus Buch, HELIOS Klinikum Berlin, Universitatsmedizin Berlin, Berlin, Germany
    JACC Cardiovasc Imaging 2:131-8. 2009
    ..We sought to assess the value of cardiac magnetic resonance (CMR) to monitor the spectrum of myocarditis-related injuries over the course of the disease...
  30. doi Hepatocellular carcinoma: signal intensity at gadoxetic acid-enhanced MR Imaging--correlation with molecular transporters and histopathologic features
    Azusa Kitao
    Department of Radiology, Human Pathology, and Gastroenterology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa 920 8640, Japan
    Radiology 256:817-26. 2010
    ....
  31. ncbi Hepatocellular carcinoma: hepatocyte-selective enhancement at gadoxetic acid-enhanced MR imaging--correlation with expression of sinusoidal and canalicular transporters and bile accumulation
    Takahiro Tsuboyama
    Department of Radiology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Radiology 255:824-33. 2010
    ..To investigate the mechanism of enhancement of hepatocellular carcinoma (HCC) on gadoxetic acid-enhanced hepatobiliary phase magnetic resonance (MR) images and to characterize HCC thus enhanced...
  32. doi Assessment of diffuse myocardial fibrosis in rats using small-animal Look-Locker inversion recovery T1 mapping
    Daniel R Messroghli
    Department of Congenital Heart Disease and Pediatric Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany
    Circ Cardiovasc Imaging 4:636-40. 2011
    ..We hypothesized that diffuse myocardial fibrosis in a small-animal model could be quantitatively assessed by measuring myocardial ECV using small-animal Look-Locker inversion recovery T1 mapping...
  33. pmc Magnetic resonance imaging delineates the ischemic area at risk and myocardial salvage in patients with acute myocardial infarction
    Colin Berry
    Department of Health and Human Services, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1061, USA
    Circ Cardiovasc Imaging 3:527-35. 2010
    ..The area at risk (AAR) is a key determinant of myocardial infarction (MI) size. We investigated whether magnetic resonance imaging (MRI) measurement of AAR would be correlated with an angiographic AAR risk score in patients with acute MI...
  34. ncbi Focal liver lesion detection and characterization with diffusion-weighted MR imaging: comparison with standard breath-hold T2-weighted imaging
    Tejas Parikh
    Department of Radiology, New York University Medical Center, 530 First Ave, MRI, New York, NY 10016, USA
    Radiology 246:812-22. 2008
    ....
  35. ncbi Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis?
    Thomas Grobner
    Department of Nephrology, General Hopsital of Wiener Neustadt, A 2700 Wiener Neustadt, Austria
    Nephrol Dial Transplant 21:1104-8. 2006
  36. doi The salvaged area at risk in reperfused acute myocardial infarction as visualized by cardiovascular magnetic resonance
    Matthias G Friedrich
    Stephenson Cardiovascular Magnetic Resonance Centre at the Libin Cardiovascular Institute of Alberta, Department of Cardiac Sciences, University of Calgary, Alberta, Canada
    J Am Coll Cardiol 51:1581-7. 2008
    ..We aimed to characterize the tissue changes within the perfusion bed of infarct-related vessels in patients with acutely reperfused myocardial infarction (MI) using cardiovascular magnetic resonance (CMR)...
  37. ncbi Dual-bolus approach to quantitative measurement of pulmonary perfusion by contrast-enhanced MRI
    Frank Risse
    Department of Medical Physics in Radiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Magn Reson Imaging 24:1284-90. 2006
    ..To evaluate a dual-bolus approach to pulmonary perfusion MRI...
  38. ncbi Pixel-by-pixel analysis of DCE MRI curve patterns and an illustration of its application to the imaging of the musculoskeletal system
    Cristina Lavini
    Department of Radiology, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
    Magn Reson Imaging 25:604-12. 2007
    ....
  39. ncbi Improved detection of focal liver lesions at MR imaging: multicenter comparison of gadoxetic acid-enhanced MR images with intraoperative findings
    Alexander Huppertz
    Institute of Clinical Radiology, Klinikum Grosshadern, University of Munich, Germany
    Radiology 230:266-75. 2004
    ....
  40. doi Comparison of gadolinium-EOB-DTPA-enhanced and diffusion-weighted liver MRI for detection of small hepatic metastases
    Kotaro Shimada
    Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto, 606 8507, Japan
    Eur Radiol 20:2690-8. 2010
    ..To compare the accuracy of gadolinium ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI with that of diffusion-weighted MRI (DWI) in the detection of small hepatic metastases (2 cm or smaller)...
  41. ncbi Comparison of the iron oxide-based blood-pool contrast medium VSOP-C184 with gadopentetate dimeglumine for first-pass magnetic resonance angiography of the aorta and renal arteries in pigs
    Jorg Schnorr
    Department of Radiology, Charite Universitatsmedizin Berlin, Germany
    Invest Radiol 39:546-53. 2004
    ..The present study was performed to determine whether VSOP-C184 is also suitable for first-pass MRA...
  42. ncbi Biliary MR imaging with Gd-EOB-DTPA and its clinical applications
    Nam Kyung Lee
    Department of Radiology, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Pusan National University, 1 10 Ami dong, Seo Gu, Busan 602 739, Republic of Korea
    Radiographics 29:1707-24. 2009
    ..However, the clinical applications of this imaging technique have not yet been fully explored, and further investigations are needed to determine the utility of Gd-EOB-DTPA-enhanced MR cholangiography in a clinical setting...
  43. doi Multifunctional gadolinium-based dendritic macromolecules as liver targeting imaging probes
    Kui Luo
    National Engineering Research Center for Biomaterials, Sichuan University, 29 Wangjiang Road, Chengdu 610064, China
    Biomaterials 32:2575-85. 2011
    ..The design strategy of multifunctional Gd-ligand peptide dendritic macromolecules in this study may be used for developing other sensitive MRI probes with targeting capability...
  44. doi Preoperative detection of colorectal liver metastases in fatty liver: MDCT or MRI?
    Vanessa Kulemann
    Department of Radiology, Medical University of Vienna, Austria
    Eur J Radiol 79:e1-6. 2011
    ....
  45. pmc Induction of the expression of profibrotic cytokines and growth factors in normal human peripheral blood monocytes by gadolinium contrast agents
    Peter J Wermuth
    Thomas Jefferson University, Jefferson Institute of Molecular Medicine, Philadelphia, Pennsylvania 19107, USA
    Arthritis Rheum 60:1508-18. 2009
    ....
  46. pmc The kinetics of blood brain barrier permeability and targeted doxorubicin delivery into brain induced by focused ultrasound
    Juyoung Park
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Ave Boston, MA 02115, USA
    J Control Release 162:134-42. 2012
    ..The results of this study provide information needed to take into account the dynamics BBB disruption over time after FUS...
  47. ncbi Gadolinium-conjugated PLA-PEG nanoparticles as liver targeted molecular MRI contrast agent
    Zhijin Chen
    School of Pharmaceutical Science, Shandong University, Ji Nan, People s Republic of China
    J Drug Target 19:657-65. 2011
    ..57 comparing with Magnevist injection. Therefore, the Gd-labeled nanoparticles showed the potential as targeting molecular MRI contrast agent for further clinical utilization...
  48. ncbi The histological basis of late gadolinium enhancement cardiovascular magnetic resonance in a patient with Anderson-Fabry disease
    James C Moon
    CMR Unit, Royal Brompton Hospital, London, United Kingdom
    J Cardiovasc Magn Reson 8:479-82. 2006
    ..This scarring may be the substrate for electrical re-entry and sudden arrhythmic death. The reasons for this distribution of fibrosis are unclear, but may reflect inhomogeneous left ventricular wall stress...
  49. doi Dynamic contrast-enhanced magnetic resonance imaging of tumor interstitial fluid pressure
    Kristine Gulliksrud
    Department of Radiation Biology, Institute for Cancer Research, Oslo, Norway
    Radiother Oncol 91:107-13. 2009
    ..The potential usefulness of gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA)-based dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for assessing tumor IFP noninvasively was investigated in the present study...
  50. ncbi Gadoxetate disodium-enhanced magnetic resonance imaging versus contrast-enhanced 18F-fluorodeoxyglucose positron emission tomography/computed tomography for the detection of colorectal liver metastases
    Hyo Jung Seo
    Division of Nuclear Medicine, Department of Radiology, Yonsei University Health System, Seoul, Republic of Korea
    Invest Radiol 46:548-55. 2011
    ....
  51. doi Gd-EOB-DTPA-enhanced 3.0 T MR imaging: quantitative and qualitative comparison of hepatocyte-phase images obtained 10 min and 20 min after injection for the detection of liver metastases from colorectal carcinoma
    Keitaro Sofue
    Division of Diagnostic Radiology, National Cancer Center Hospital, 5 1 1, Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Eur Radiol 21:2336-43. 2011
    ..0 T MR imaging...
  52. ncbi Single breath-hold assessment of ventricular volumes using 32-channel coil technology and an extracellular contrast agent
    Victoria Parish
    Division of Imaging Sciences, NIHR Biomedical Research Centre at Guy s and St Thomas NHS Foundation Trust, King s College London, London, UK
    J Magn Reson Imaging 31:838-44. 2010
    ..To evaluate the feasibility of a single breath-hold 3D cine balanced steady-state free precession (b-SSFP) sequence after gadolinium diethylenetriamine penta-acetic acid (Gd-DTPA) injection for volumetric cardiac assessment...
  53. pmc T1 Mapping in cardiomyopathy at cardiac MR: comparison with endomyocardial biopsy
    Christopher T Sibley
    Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering, Department of Health and Human Services, 10 Center Dr, Building 10, MSC 1182, Bethesda, MD 20892 1182, USA
    Radiology 265:724-32. 2012
    ..To determine the utility of cardiac magnetic resonance (MR) T1 mapping for quantification of diffuse myocardial fibrosis compared with the standard of endomyocardial biopsy...
  54. doi Reproducibility of imaging human knee cartilage by delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at 1.5 Tesla
    J Multanen
    Department of Health Sciences, University of Jyvaskyla, Jyvaskyla, Finland
    Osteoarthritis Cartilage 17:559-64. 2009
    ..The purpose of this study was to investigate the day-to-day reproducibility of the delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) measurement at different knee joint surfaces in healthy subjects at 1.5 Tesla (T)...
  55. doi Value of retrospective fusion of PET and MR images in detection of hepatic metastases: comparison with 18F-FDG PET/CT and Gd-EOB-DTPA-enhanced MRI
    Olivio F Donati
    Institute of Diagnostic Radiology, University Hospital Zurich, Zurich, Switzerland
    J Nucl Med 51:692-9. 2010
    ....
  56. doi Incorporation of excess gadolinium into human bone from medical contrast agents
    Thomas H Darrah
    Department of Earth and Environmental Sciences, University of Rochester, Rochester, NY 14627, USA
    Metallomics 1:479-88. 2009
    ..g. osteoporosis patients and menopausal, pregnant, and lactating women) who are exposed to Gd-based contrast agents...
  57. doi Comparison of gadoxetic acid-enhanced dynamic imaging and diffusion-weighted imaging for the preoperative evaluation of colorectal liver metastases
    Woo Suk Chung
    Department of Diagnostic Radiology, Institute of Gastroenterology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
    J Magn Reson Imaging 34:345-53. 2011
    ..0 Tesla (T) system, and then to determine whether a combination of the two techniques may improve the diagnostic performance...
  58. doi Myocardial delayed enhancement in patients with pulmonary hypertension and right ventricular failure: evaluation by cardiac MRI
    F P Junqueira
    Clinica de Diagnostico por Imagem, Av das Américas 4666 sala 325, Barra da Tijuca, Rio de Janeiro RJ, Brazil
    Br J Radiol 82:821-6. 2009
    ..We found that septal MDE can be present in patients with PAH and impaired ventricular function. However, further studies are necessary to investigate this possible association and its prognostic implication...
  59. ncbi Association between diffuse myocardial fibrosis by cardiac magnetic resonance contrast-enhanced T₁ mapping and subclinical myocardial dysfunction in diabetic patients: a pilot study
    Arnold C T Ng
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Circ Cardiovasc Imaging 5:51-9. 2012
    ..However, the association between MRI T(1) mapping and subtle left ventricular (LV) dysfunction in diabetic patients is unknown...
  60. pmc Blood-brain barrier: real-time feedback-controlled focused ultrasound disruption by using an acoustic emissions-based controller
    Meaghan A O'Reilly
    Physical Science Platform, Sunnybrook Research Institute, Toronto, ON, Canada M4N 3M5
    Radiology 263:96-106. 2012
    ..To determine if focused ultrasound disruption of the blood-brain barrier (BBB) can be safely controlled by using real-time modulation of treatment pressures on the basis of acoustic emissions from the exposed microbubbles...
  61. ncbi Comparison of arterial spin labeling and first-pass dynamic contrast-enhanced MR imaging in the assessment of pulmonary perfusion in humans: the inflow spin-tracer saturation effect
    Yi Ru Lin
    Department of Electrical Engineering, National Taiwan University, Taipei, Republic of China
    Magn Reson Med 52:1291-301. 2004
    ....
  62. ncbi Diffusion-weighted MR imaging of liver on 3.0-Tesla system: effect of intravenous administration of gadoxetic acid disodium
    Ji Soo Choi
    Department of Radiology, Severance Hospital and Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea
    Eur Radiol 20:1052-60. 2010
    ..0 t...
  63. doi 3D time-resolved MR angiography (MRA) of the carotid arteries with time-resolved imaging with stochastic trajectories: comparison with 3D contrast-enhanced Bolus-Chase MRA and 3D time-of-flight MRA
    R P Lim
    Department of Radiology, NYU Langone Medical Center, New York, NY, USA
    AJNR Am J Neuroradiol 29:1847-54. 2008
    ....
  64. doi Freehand MRI-guided preoperative needle localization of breast lesions after MRI-guided vacuum-assisted core needle biopsy without marker placement
    Stephanie M W Y van de Ven
    Department of Radiology, Stanford University Medical Center, Stanford, California, USA
    J Magn Reson Imaging 32:101-9. 2010
    ..To evaluate the feasibility of magnetic resonance imaging (MRI)-guided preoperative needle localization (PNL) of breast lesions previously sampled by MRI-guided vacuum-assisted core needle biopsy (VACNB) without marker placement...
  65. doi Planning transarterial radioembolization of colorectal liver metastases with Yttrium 90 microspheres: evaluation of a sequential diagnostic approach using radiologic and nuclear medicine imaging techniques
    Timm Denecke
    Klinik fur Strahlenheilkunde, Bereiche Radiologie und Nuklearmedizin, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Eur Radiol 18:892-902. 2008
    ..Each part of the diagnostic algorithm showed a relevant impact on patient management. The sequential approach appears to be suitable and keeps the number of unnecessary treatments and therapy risks to a minimum...
  66. doi Gadoxetate disodium-enhanced MRI of the liver: part 1, protocol optimization and lesion appearance in the noncirrhotic liver
    Kristina I Ringe
    Department of Radiology, Duke University Medical School, Durham, NC 27710, USA
    AJR Am J Roentgenol 195:13-28. 2010
    ....
  67. ncbi Diagnostic efficacy of gadoxetic acid (Primovist)-enhanced MRI and spiral CT for a therapeutic strategy: comparison with intraoperative and histopathologic findings in focal liver lesions
    Renate Hammerstingl
    Institute of Diagnostic and Interventional Radiology, Johann Wolfgang Goethe University, ZRad, Haus 23 C, Theodor Stern Kai 7, 60590, Frankfurt am Main, Germany
    Eur Radiol 18:457-67. 2008
    ..0%). A change in surgical therapy was documented in 19 of 131 patients (14.5%) post Gd-EOB-DTPA-enhanced MRI. Gd-EOB-DTPA-enhanced MRI was superior in the diagnosis and therapeutic management of focal liver lesions compared with CT...
  68. doi High signal intensity halo around the carotid artery on maximum intensity projection images of time-of-flight MR angiography: a new sign for intraplaque hemorrhage
    Yoo Jeong Yim
    Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Magn Reson Imaging 27:1341-6. 2008
    ..To evaluate the value of the high signal intensity halo sign as a new marker of a fresh or recent intraplaque hemorrhage on the maximum intensity projection (MIP) images of time-of-flight (TOF) MR angiography...
  69. doi Cirrhotic rat liver: reference to transporter activity and morphologic changes in bile canaliculi--gadoxetic acid-enhanced MR imaging
    Natsuko Tsuda
    Department of Diagnostic Imaging Medical Affairs, Bayer Yakuhin, Kita ku, Osaka, Osaka, Japan
    Radiology 256:767-73. 2010
    ....
  70. ncbi Gadolinium enhanced cardiovascular magnetic resonance in Anderson-Fabry disease. Evidence for a disease specific abnormality of the myocardial interstitium
    James C C Moon
    Centre for Advanced Magnetic Resonance in Cardiology CAMRIC, Royal Brompton Hospital, London, UK
    Eur Heart J 24:2151-5. 2003
    ..Gadolinium enhanced cardiovascular magnetic resonance can detect focal myocardial fibrosis. We hypothesised that hyperenhancement would be present in AFD...
  71. ncbi The 2008 Okuda lecture: Management of hepatocellular carcinoma: from surveillance to molecular targeted therapy
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    J Gastroenterol Hepatol 25:439-52. 2010
    ..In conclusion, it is expected that readers will gain deeper insight into the latest progress and updated diagnosis and treatment of HCC described in this review...
  72. doi Acute myocardial infarction: serial cardiac MR imaging shows a decrease in delayed enhancement of the myocardium during the 1st week after reperfusion
    Tareq Ibrahim
    Department of Cardiology, Klinikums Rechts der Isar and German Heart Centre Munich, Munich, Germany
    Radiology 254:88-97. 2010
    ..To evaluate the time course of delayed gadolinium enhancement of infarcted myocardium by using serial contrast agent-enhanced (CE) cardiac magnetic resonance (MR) images obtained during the acute, subacute, and chronic stages of infarction...
  73. doi Detection and characterization of focal liver lesions: a Japanese phase III, multicenter comparison between gadoxetic acid disodium-enhanced magnetic resonance imaging and contrast-enhanced computed tomography predominantly in patients with hepatocellular
    Tomoaki Ichikawa
    Department of Radiology, University of Yamanashi, School of Medicine, Yamanashi, Japan
    Invest Radiol 45:133-41. 2010
    ....
  74. ncbi The role of cardiovascular magnetic resonance in patients presenting with chest pain, raised troponin, and unobstructed coronary arteries
    Ravi G Assomull
    Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, London SW3 6NP, UK
    Eur Heart J 28:1242-9. 2007
    ..However, some patients have no coronary obstruction on angiography, leading to diagnostic uncertainty. We evaluated the incremental diagnostic value of cardiovascular magnetic resonance (CMR) in these patients...
  75. ncbi Gadoxetic acid-enhanced magnetic resonance imaging for differentiating small hepatocellular carcinomas (< or =2 cm in diameter) from arterial enhancing pseudolesions: special emphasis on hepatobiliary phase imaging
    Hye Young Sun
    Department of Radiology, Seoul National University College of Medicine, Seoul, Korea
    Invest Radiol 45:96-103. 2010
    ....
  76. ncbi Prediction of clinicopathologic response of breast cancer to primary chemotherapy at contrast-enhanced MR imaging: initial clinical results
    Anwar R Padhani
    Cancer Research UK Clinical Magnetic Resonance Research Group and the Breast Unit, Institute of Cancer Research and the Royal Marsden NHS Trust, Surrey, England
    Radiology 239:361-74. 2006
    ....
  77. ncbi Liver tumor characterization: comparison between liver-specific gadoxetic acid disodium-enhanced MRI and biphasic CT--a multicenter trial
    Juha Halavaara
    Jorvi Hospital, Department of Radiology, Espoo, Finland
    J Comput Assist Tomogr 30:345-54. 2006
    ....
  78. ncbi Hepatobiliary contrast agents for contrast-enhanced MRI of the liver: properties, clinical development and applications
    Peter Reimer
    Department of Radiology, Stadtisches Klinikum Karlsruhe, Academic Teaching Hospital of the University of Freiburg, Moltkestrasse 90, 76133 Karlsruhe, Germany
    Eur Radiol 14:559-78. 2004
    ..No comparative studies have been conducted comparing the advantages or disadvantages of all three agents directly against each other...
  79. ncbi Thick-section half-Fourier rapid acquisition with relaxation enhancement MR cholangiopancreatography: effects of i.v. administration of gadolinium chelate
    Masayuki Kanematsu
    Department of Radiology, Gifu University School of Medicine, 40 Tsukasamachi, Gifu, 500 8705, Japan
    AJR Am J Roentgenol 178:755-61. 2002
    ..Our purpose was to investigate the effects of i.v. administration of gadolinium chelate on thick-section MR cholangiopancreatography performed with half-Fourier rapid acquisition with relaxation enhancement sequence...
  80. ncbi Effects of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid on T2-weighted MRCP
    Yuko Nakamura
    Department of Radiology, Kure City Medical Association Hospital, Kure, Hiroshima, Japan
    Magn Reson Med Sci 8:143-8. 2009
    ..Examination time cannot be extended if the contrast does not take effect on T(2)-weighted MRCP within 20 min after administration. We attempted to assess the change in signal of T(2)-weighted MRCP by excretion of Gd-EOB-DTPA...
  81. pmc T1-weighted cine FLASH is superior to IR imaging of post-infarction myocardial viability at 4.7T
    D Thomas
    Department of Radiology and Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Cardiovasc Magn Reson 8:345-52. 2006
    ..We implemented a widely used clinical inversion recovery (IR) sequence at 4.7T and compared the results to a heavily T1-weighted cine FLASH sequence (T1-CF) for assessment of infarction size...
  82. ncbi Imaging time after Gd-DTPA injection is critical in using delayed enhancement to determine infarct size accurately with magnetic resonance imaging
    Robert M Judd
    Circulation 106:e6; author reply e6. 2002
  83. ncbi Highly accelerated first-pass contrast-enhanced magnetic resonance angiography of the peripheral vasculature: comparison of gadofosveset trisodium with gadopentetate dimeglumine contrast agents
    Jeffrey H Maki
    Department of Radiology, University of Washington, Puget Sound VAHCS, Seattle, Washington 98108, USA
    J Magn Reson Imaging 30:1085-92. 2009
    ..To investigate the blood pool agent gadofosveset trisodium for first-pass, dynamic peripheral contrast-enhanced magnetic resonance angiography (pMRA), and compare the results with a conventional gadolinium contrast agent...
  84. ncbi Reliability of pharmacokinetic parameters: small vs. medium-sized contrast agents
    Karolien Jaspers
    Department of Radiology, Maastricht University Medical Centre, Maastricht, The Netherlands
    Magn Reson Med 62:779-87. 2009
    ..7 min for K(trans) and v(e)). Reliable estimation of the fractional blood plasma volume (v(p)) was only achieved with MCAs. In conclusion, MCAs provided superior reliability for pharmacokinetic parameter estimation compared to SCAs...
  85. ncbi MRI findings of focal eosinophilic liver diseases
    Young Kon Kim
    Department of Diagnostic Radiology, Chonbuk National University Hospital, Chonju, Korea
    AJR Am J Roentgenol 184:1541-8. 2005
    ..The purpose of this study was to describe the MRI findings of focal eosinophilic infiltration and eosinophilic abscess of the liver...
  86. pmc Double contrast-enhanced MRI of viral hepatitis-induced cirrhosis: correlation of gross morphological signs with hepatic fibrosis
    J S Yu
    Department of Radiology and the Research Institute of Radiological Science, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul, Republic of Korea
    Br J Radiol 83:212-7. 2010
    ....
  87. doi Assessment of hepatic extraction fraction and input relative blood flow using dynamic hepatocyte-specific contrast-enhanced MRI
    Henrik Nilsson
    Karolinska Institutet, Sweden
    J Magn Reson Imaging 29:1323-31. 2009
    ..To assess the feasibility to use dynamic hepatocyte-specific contrast-enhanced MRI (DHCE-MRI) as an imaging-based liver function test, and to compare two methods for deconvolutional analysis (DA) in healthy human subjects...
  88. ncbi Assessment of resting perfusion defects in patients with acute myocardial infarction: comparison of myocardial contrast echocardiography, combined first-pass/delayed contrast-enhanced magnetic resonance imaging and 99mTC-sestamibi SPECT
    Antonella Lombardo
    Department of Cardiology, Catholic University, Roma, Italy
    Int J Cardiovasc Imaging 22:417-28. 2006
    ..We evaluated the accuracy of MRI and MCE, using Single Photon Emission Computed Tomography (SPECT) imaging as reference technique...
  89. ncbi Quantitative myocardial infarction on delayed enhancement MRI. Part I: Animal validation of an automated feature analysis and combined thresholding infarct sizing algorithm
    Li Yueh Hsu
    Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health DHHS, 10 Center Drive, Bethesda, MD 20892, USA
    J Magn Reson Imaging 23:298-308. 2006
    ..To develop a computer algorithm to measure myocardial infarct size in gadolinium-enhanced magnetic resonance (MR) imaging and to validate this method using a canine histopathological reference...
  90. ncbi Eosinophilic hepatic necrosis: magnetic resonance imaging and computed tomography comparison
    Jeong Sik Yu
    Department of Diagnostic Radiology and the Research Institute of Radiological Science, Yonsei University College of Medicine, Yongdong Severance Hospital, Seoul, South Korea
    J Comput Assist Tomogr 29:765-71. 2005
    ..To compare the findings of magnetic resonance (MR) imaging with those of computed tomography (CT) of focal liver lesions related to peripheral eosinophilia...
  91. ncbi Magnetic resonance first pass perfusion imaging for detecting coronary artery disease
    Christopher Klassen
    Department of Radiology, 655 West Eight Street, Jacksonville, FL 32209, USA
    Eur J Radiol 57:412-6. 2006
    ..Perfusion imaging defines the physiology and angiography in the anatomy of coronary artery disease...
  92. ncbi MR findings in eosinophilic infiltration of the liver
    Joo Sung Sun
    Department of Diagnostic Radiology, Ajou University, College of Medicine, Kyunggido, Korea
    J Comput Assist Tomogr 29:191-4. 2005
    ..This study describes the findings of magnetic resonance imaging (MRI) of focal eosinophilic infiltration of the liver...
  93. doi Gd-EOB-DTPA-enhanced magnetic resonance images of hepatocellular carcinoma: correlation with histological grading and portal blood flow
    Sachiyo Kogita
    Department of Gastroenterology, Ikeda Municipal Hospital, 3 1 18, Johnan, Ikeda, Osaka, 563 8510, Japan
    Eur Radiol 20:2405-13. 2010
    ....
  94. pmc Quantitative evaluation of liver function with MRI Using Gd-EOB-DTPA
    Hun Kyu Ryeom
    Department of Radiology, Kyungpook National University School of Medicine, Taegu, Korea
    Korean J Radiol 5:231-9. 2004
    ..The purpose of this study is to develop a noninvasive method of quantitation of the hepatic function using Gd-EOB-DTPA through the deconvolution analysis...
  95. ncbi Magnetic resonance angiography with gadomer-17. An animal study original investigation
    Q Dong
    Department of Radiology, University of Michigan, Ann Arbor 48109 0030, USA
    Invest Radiol 33:699-708. 1998
    ....
  96. pmc Assessment of myocardial infarction in mice by late gadolinium enhancement MR imaging using an inversion recovery pulse sequence at 9.4T
    Catherine Chapon
    Stem Cell Imaging, MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College London, UK
    J Cardiovasc Magn Reson 10:6. 2008
    ..4T, and to obtain the maximal contrast between the infarcted and the viable myocardium...
  97. ncbi Differentiation between the effects of T1 and T2* shortening in contrast-enhanced MRI of the breast
    V Y Kuperman
    Department of Radiology, University of Chicago, Illinois 60637, USA
    J Magn Reson Imaging 9:172-6. 1999
    ..The feasibility of the technique for in vivo MRI and increased lesion contrast is demonstrated. The results indicate that this technique may improve detection of malignant breast tissue...
  98. pmc First-pass contrast-enhanced myocardial perfusion MRI in mice on a 3-T clinical MR scanner
    Marcus Makowski
    Division of Imaging Sciences, The Rayne Institute, King s College London, St Thomas Campus, London, United Kingdom
    Magn Reson Med 64:1592-8. 2010
    ..Data were acquired on a 3-T scanner, using an approach similar to clinical acquisition protocols, thus facilitating translation of imaging findings between rodent and human studies...
  99. pmc Assessment of liver function in primary biliary cirrhosis using Gd-EOB-DTPA-enhanced liver MRI
    Henrik Nilsson
    Department of Clinical Sciences, Karolinska Institutet, Stockholm, Sweden
    HPB (Oxford) 12:567-76. 2010
    ..The aim of this study was to determine whether the hepatic uptake and excretion of Gd-EOB-DTPA differ between patients with primary biliary cirrhosis (PBC) and healthy controls, and whether differences could be quantified...
  100. ncbi Effect of gadolinium concentration on renal signal intensity: An in vitro study with a saline bag model
    D A May
    Department of Radiology, Medical College of Virginia of Virginia Commonwealth University, PO Box 980615, Richmond, VA 23298 0615, USA
    Radiology 216:232-6. 2000
    ..To compare the effects of gadolinium concentration on intermediate-weighted fast inversion-recovery and T2-weighted fast spin-echo magnetic resonance (MR) images by using a saline bag model of the kidney...
  101. ncbi Whole brain quantitative CBF, CBV, and MTT measurements using MRI bolus tracking: implementation and application to data acquired from hyperacute stroke patients
    A M Smith
    Department of Radiology and Medical Imaging, Universite Catholique de Louvain, St Luc University Hospital, B 1200 Brussels, Belgium
    J Magn Reson Imaging 12:400-10. 2000
    ..J. Magn. Reson. Imaging 2000;12:400-410...

Research Grants113 found, 100 shown here

  1. ANATOMIC AND BIOLOGIC STAGING OF BREAST DISEASE WITH MRI
    Nola Hylton; Fiscal Year: 2005
    ..MRI methods will be developed using both standard gadolinium-DTPA and gadolinium-encapsulating immunoliposomes. ..
  2. Matrix Metalloproteinases and the Blood-Brain Barrier
    GARY ALLEN ROSENBERG; Fiscal Year: 2010
    ..Matrix metalloproteinase inhibitors will be studied that have the potential to be used to prevent the death of vulnerable cells in the white matter. ..
  3. Matrix Metalloproteinases and the Blood-Brain Barrier
    Gary Rosenberg; Fiscal Year: 2009
    ..Matrix metalloproteinase inhibitors will be studied that have the potential to be used to prevent the death of vulnerable cells in the white matter. ..
  4. MR-Guided Endovascular Intervention Using Off-Resonance Contrast Angiography
    Robert Edelman; Fiscal Year: 2009
    ..This study will result in a better understanding of the basic contrast mechanisms and will lead to improved treatment strategies for renovascular hypertension using MR-guided interventional procedures. ..
  5. MR-Guided Endovascular Intervention Using Off-Resonance Contrast Angiography
    Robert R Edelman; Fiscal Year: 2010
    ..This study will result in a better understanding of the basic contrast mechanisms and will lead to improved treatment strategies for renovascular hypertension using MR-guided interventional procedures. ..
  6. EFFECT OF HYPONATREMIA ON BRAIN PH FUNCTION MORPHOLOGY
    SHELDON ADLER; Fiscal Year: 1991
    ....
  7. FEASIBILITY OF OVERHAUSER-ENHANCED MR MAMMOGRAPHY
    James Lee; Fiscal Year: 1993
    ..This will determine the feasibility of using Overhauser enhanced imaging for breast cancer detection, and indicate the degree of field reduction that produces optimum results...
  8. Magnetic resonance angiography
    Christopher Reinhardt; Fiscal Year: 2005
    ..abstract_text> ..
  9. Magnetic resonance angiography
    Christopher Reinhardt; Fiscal Year: 2007
    ..abstract_text> ..
  10. Glycopolymer Contrast Agents for Cardiovascular MRI
    THERESA REINEKE; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  11. MRI OF RENAL ANATOMY AND FUNCTION IN CHRONIC ISCHEMIA
    Frank Sommer; Fiscal Year: 2000
    ..The utility of the comprehensive exam will be determined by correlating pre- intervention MRI-determined parameters with both clinical outcome measures and post-intervention MRI-determined parameters. ..
  12. MRI OF RENAL ANATOMY AND FUNCTION IN CHRONIC ISCHEMIA
    Frank Sommer; Fiscal Year: 1999
    ..The utility of the comprehensive exam will be determined by correlating pre- intervention MRI-determined parameters with both clinical outcome measures and post-intervention MRI-determined parameters. ..
  13. MRI OF RENAL ANATOMY AND FUNCTION IN CHRONIC ISCHEMIA
    Frank Sommer; Fiscal Year: 2002
    ..The utility of the comprehensive exam will be determined by correlating pre- intervention MRI-determined parameters with both clinical outcome measures and post-intervention MRI-determined parameters. ..
  14. MRI OF RENAL ANATOMY AND FUNCTION IN CHRONIC ISCHEMIA
    Frank Sommer; Fiscal Year: 2001
    ..The utility of the comprehensive exam will be determined by correlating pre- intervention MRI-determined parameters with both clinical outcome measures and post-intervention MRI-determined parameters. ..
  15. TUMOR OXYGENATION, HYPOXIA, AND RADIATION RESPONSE
    Bruce Fenton; Fiscal Year: 1999
    ..A final goal will be to combine oxygen manipulative agents with fractionated radiotherapy, in order to better understand the combined physiological effects and to provide a basis for selecting optimal time points. ..
  16. PLATFORMS FOR IMAGING/TREATMENT OF INTRACRANIAL NEOPLASM
    Martin Philbert; Fiscal Year: 2001
    ..abstract_text> ..
  17. ANATOMIC AND BIOLOGIC STAGING OF BREAST DISEASE WITH MRI
    Nola Hylton; Fiscal Year: 2002
    ..MRI methods will be developed using both standard gadolinium-DTPA and gadolinium-encapsulating immunoliposomes. ..
  18. Ultra-Sensitive MR Probes for Molecular Diagnosis of Lung Cancer
    Jinming Gao; Fiscal Year: 2009
    ..This knowledge can facilitate timely intervention of lung cancer to achieve personalized medicine. ..
  19. ANATOMIC AND BIOLOGIC STAGING OF BREAST DISEASE WITH MRI
    Nola Hylton; Fiscal Year: 2003
    ..MRI methods will be developed using both standard gadolinium-DTPA and gadolinium-encapsulating immunoliposomes. ..
  20. Ultra-Sensitive MR Probes for Molecular Diagnosis of Lung Cancer
    Jinming Gao; Fiscal Year: 2010
    ..This knowledge can facilitate timely intervention of lung cancer to achieve personalized medicine. ..
  21. ANATOMIC AND BIOLOGIC STAGING OF BREAST DISEASE WITH MRI
    Nola Hylton; Fiscal Year: 2004
    ..MRI methods will be developed using both standard gadolinium-DTPA and gadolinium-encapsulating immunoliposomes. ..
  22. ANATOMIC AND BIOLOGIC STAGING OF BREAST DISEASE WITH MRI
    Nola Hylton; Fiscal Year: 2001
    ..MRI methods will be developed using both standard gadolinium-DTPA and gadolinium-encapsulating immunoliposomes. ..
  23. Pathobiology of Vascular Cognitive Impairment
    GARY ALLEN ROSENBERG; Fiscal Year: 2010
    ..These studies will determine the role of protease-mediated nflammation in the progressive form of SIVD, and could lead to novel treatments to suppress proteases. ..
  24. Pathobiology of Vascular Cognitive Impairment
    Gary Rosenberg; Fiscal Year: 2009
    ..These studies will determine the role of protease-mediated nflammation in the progressive form of SIVD, and could lead to novel treatments to suppress proteases. ..
  25. Pathobiology of Vascular Cognitive Impairment
    Gary Rosenberg; Fiscal Year: 2007
    ..These studies will determine the role of protease-mediated nflammation in the progressive form of SIVD, and could lead to novel treatments to suppress proteases. [unreadable] [unreadable] [unreadable]..
  26. Pathobiology of Vascular Cognitive Impairment
    Gary Rosenberg; Fiscal Year: 2009
    ..These studies will determine the role of protease-mediated nflammation in the progressive form of SIVD, and could lead to novel treatments to suppress proteases. ..
  27. Pathobiology of Vascular Cognitive Impairment
    Gary Rosenberg; Fiscal Year: 2009
    ..These studies will determine the role of protease-mediated nflammation in the progressive form of SIVD, and could lead to novel treatments to suppress proteases. ..
  28. Pathobiology of Vascular Cognitive Impairment
    Gary Rosenberg; Fiscal Year: 2006
    ..These studies will determine the role of protease-mediated nflammation in the progressive form of SIVD, and could lead to novel treatments to suppress proteases. [unreadable] [unreadable] [unreadable]..
  29. MRI Quantification of Postinfarct Myocardial Viability
    PAL SURANYI; Fiscal Year: 2005
    ..TTC perfusion of the same dogs as above will be carried out at the end of the MRI session and heart will be immediately excised for histology, to ensure comparison with the in vivo results at the same time point. ..
  30. PREDICTING HUMAN TUMOR RESPONSE BY 31P MRS
    HAL CHARLES; Fiscal Year: 1999
    ..The working hypotheses are that pretherapy and proximal posththerapy 31-P MRS metabolite levels, pH, and t2 values will be prognostic of treatment outcome. ..
  31. In vivo Image Guided Cancer Therapy
    Anna Moore; Fiscal Year: 2006
    ..If successful, this study can further be translated into clinical applications, since related iron oxides have already been tested in clinical trials. [unreadable] [unreadable] [unreadable]..
  32. In vivo Image Guided Cancer Therapy
    Anna Moore; Fiscal Year: 2007
    ..If successful, this study can further be translated into clinical applications, since related iron oxides have already been tested in clinical trials. [unreadable] [unreadable] [unreadable]..
  33. 3D MECHANICAL MORPHOMETRY
    G Johnson; Fiscal Year: 1999
    ..Magnevist will be used as the fill solution. Two different types of closures will be imaged, each with subtle internal structural differences. ..
  34. Quantitative Vascular Image Analysis system
    William Kerwin; Fiscal Year: 2008
    ..The VIL will develop a standardized training program, train the participating clinical sites, and act as the overall clinical data manager. ..
  35. MR Guided Transendocardial Angiogenic Agents
    Maythem Saeed; Fiscal Year: 2007
    ..abstract_text> ..
  36. MR Guided Transendocardial Angiogenic Agents
    Maythem Saeed; Fiscal Year: 2004
    ..abstract_text> ..
  37. MR Guided Transendocardial Angiogenic Agents
    Maythem Saeed; Fiscal Year: 2006
    ..abstract_text> ..
  38. NMR STUDIES OF HEMORRHAGIC TRANSFORMATION IN ISCHEMIA
    Robert Knight; Fiscal Year: 2000
    ....
  39. MRI of Acute Vascular Injury and Hemorrhagic Transformation in Ischemic Stroke
    Robert A Knight; Fiscal Year: 2010
    ..e., BBB opening) and both will be functions of the variations in BBB associated proteins and/or brain swelling;and 2) the size of these changes are correlated over time, ROI, and treatment. ..
  40. MRI of Acute Vascular Injury and Hemorrhagic Transformation in Ischemic Stroke
    Robert Knight; Fiscal Year: 2009
    ..e., BBB opening) and both will be functions of the variations in BBB associated proteins and/or brain swelling;and 2) the size of these changes are correlated over time, ROI, and treatment. ..
  41. NMR STUDIES OF HEMORRHAGIC TRANSFORMATION IN ISCHEMIA
    Robert Knight; Fiscal Year: 2001
    ....
  42. MRI Evaluation of Tumor Growth and Treatment Response
    THOMAS YANKEELOV; Fiscal Year: 2007
    ..abstract_text> ..
  43. Evaluation and Validation of Imaging Biomarkers of Tumor Response to Treatment
    Thomas E Yankeelov; Fiscal Year: 2010
    ....
  44. Evaluation of MRI Biomarkers of Breast Cancer Response
    THOMAS YANKEELOV; Fiscal Year: 2008
    ..We hypothesize that the combined analysis of contrast enhanced MRI and diffusion MRI data will provide predictive, non-invasive measurements of tumor response to treatment. ..
  45. Evaluation of MRI Biomarkers of Breast Cancer Response
    Thomas E Yankeelov; Fiscal Year: 2010
    ..We hypothesize that the combined analysis of contrast enhanced MRI and diffusion MRI data will provide predictive, non-invasive measurements of tumor response to treatment. ..
  46. MRI Evaluation of Tumor Growth and Treatment Response
    THOMAS YANKEELOV; Fiscal Year: 2008
    ..abstract_text> ..
  47. Evaluation of MRI Biomarkers of Breast Cancer Response
    THOMAS YANKEELOV; Fiscal Year: 2009
    ..We hypothesize that the combined analysis of contrast enhanced MRI and diffusion MRI data will provide predictive, non-invasive measurements of tumor response to treatment. ..
  48. A Novel Magnetic Resonance Imaging Marker of Myocardial Fibrosis
    Michael Jerosch Herold; Fiscal Year: 2011
    ..We propose the development of a novel method for assessment of diffuse fibrosis in the heart muscle with magnetic resonance imaging. ..
  49. MR Guided Transendocardial Angiogenic Agents
    Maythem Saeed; Fiscal Year: 2007
    ..abstract_text> ..
  50. Comprehensive Magnetic Resonance in PAD
    Christopher M Kramer; Fiscal Year: 2010
    ..One such therapy that will be tested is raising HDL cholesterol, so-called "good" cholesterol, with a new formulation of niacin. ..
  51. Comprehensive Magnetic Resonance in PAD
    Christopher Kramer; Fiscal Year: 2008
    ..Improving the health outcomes and quality of life in patients with PAD is a major goal of this proposal. ..
  52. Multiparametric MRI characterization of breast tissue
    Michael Jacobs; Fiscal Year: 2009
    ..abstract_text> ..
  53. NMR STUDIES OF HEMORRHAGIC TRANSFORMATION IN ISCHEMIA
    Robert Knight; Fiscal Year: 1999
    ....
  54. Comprehensive Magnetic Resonance in PAD
    Christopher Kramer; Fiscal Year: 2006
    ..These studies will enhance the understanding of statin-mediated plaque regression and stabilization and improved end organ function in PAD and lay the groundwork for the study of other novel therapies. ..
  55. Multiparametric MRI characterization of breast tissue
    Michael Jacobs; Fiscal Year: 2004
    ..abstract_text> ..
  56. MR Guided Transendocardial Angiogenic Agents
    Maythem Saeed; Fiscal Year: 2005
    ..abstract_text> ..
  57. MYOCARDIAL PERFUSION, RISK FACTORS, AND CORONARY CALCIUM
    Michael Jerosch Herold; Fiscal Year: 2003
    ..S. there is strong interest in developing such new measures of subclinical disease which would provide an early opportunity for intervention and lifestyle modification to prevent CHD and/or congestive heart failure. ..
  58. NMR STUDIES OF HEMORRHAGIC TRANSFORMATION IN ISCHEMIA
    Robert Knight; Fiscal Year: 2002
    ....
  59. A Seven Tesla MRI System for Small Animals MRI/MRS
    Robert Knight; Fiscal Year: 2007
    ..This Shared Instrumentation Grant will partially supply the funds to bring the present MRI/MRS system up to current standards, with HFHS supplying the rest. [unreadable] [unreadable] [unreadable]..
  60. Multiparametric MRI characterization of breast tissue
    Michael Jacobs; Fiscal Year: 2006
    ..abstract_text> ..
  61. A Novel Magnetic Resonance Imaging Marker of Myocardial Fibrosis
    Michael Jerosch Herold; Fiscal Year: 2010
    ..We propose the development of a novel method for assessment of diffuse fibrosis in the heart muscle with magnetic resonance imaging. ..
  62. Comprehensive Magnetic Resonance in PAD
    Christopher Kramer; Fiscal Year: 2003
    ..These studies will enhance the understanding of statin-mediated plaque regression and stabilization and improved end organ function in PAD and lay the groundwork for the study of other novel therapies. ..
  63. MRI OF COLLATERAL DEVELOPMENT IN THE HEART
    Michael Jerosch Herold; Fiscal Year: 2000
    ....
  64. Multiparametric MRI characterization of breast tissue
    Michael Jacobs; Fiscal Year: 2007
    ..abstract_text> ..
  65. MYOCARDIAL PERFUSION, RISK FACTORS, AND CORONARY CALCIUM
    Michael Jerosch Herold; Fiscal Year: 2001
    ..S. there is strong interest in developing such new measures of subclinical disease which would provide an early opportunity for intervention and lifestyle modification to prevent CHD and/or congestive heart failure. ..
  66. MRI OF COLLATERAL DEVELOPMENT IN THE HEART
    Michael Jerosch Herold; Fiscal Year: 2001
    ....
  67. REGIONAL BETA ADRENERGIC DURING LV REMODELING
    Christopher Kramer; Fiscal Year: 2001
    ..Effects of beta-blockade on regional cell morphometry, collagen content, and blood flow will be assessed using isolated myocytes, quantitative histopathology, and fluorescent microspheres, respectively. ..
  68. Quantifying Collateral Perfusion in Cerebrovascular Disease
    GREGORY ZAHARCHUK; Fiscal Year: 2009
    ....
  69. Cardiac MRI with 3D Undersampled Radial Imaging
    DANA PETERS; Fiscal Year: 2008
    ..The high resolution 3D radial viability technique will be validated in animals, and also used in patients. ..
  70. Longitudinal Study of Predictors and Consequences of Chronic Kidney Disease
    Brad Astor; Fiscal Year: 2009
    ..In addition, it will provide much-needed data to be shared with the larger scientific community on serologic and genetic risk factors for CKD, a growing public health concern in the US. ..
  71. Osteoarthritis following ACL reconstruction
    Braden Fleming; Fiscal Year: 2004
    ..abstract_text> ..
  72. In vivo multichannel fluorescent imaging
    Umar Mahmood; Fiscal Year: 2003
    ....
  73. Molecular and Microstructural Imaging of Cardiomyocyte Apoptosis and Autophagy
    David Sosnovik; Fiscal Year: 2009
    ..The development of such strategies has the potential to significantly reduce the rapidly rising number of patients with heart failure, and is thus of major clinical and public health significance. ..
  74. Biologically Enhanced Healing of Autograft ACL Reconstruction.
    Martha M Murray; Fiscal Year: 2010
    ....
  75. Nephrogenic Systemic Fibrosis (NSF): A Rodent Model for Therapeutic Intervention
    Wassana Yantasee; Fiscal Year: 2010
    ....
  76. Biologically Enhanced Healing of Autograft ACL Reconstruction
    Braden Fleming; Fiscal Year: 2009
    ....
  77. Osteoarthritis following ACL reconstruction
    Braden Fleming; Fiscal Year: 2006
    ..abstract_text> ..
  78. MR Diffusion Tensor Imaging for Detection and Characterization of Breast Lesions
    SAVANNAH CORRINA PARTRIDGE; Fiscal Year: 2010
    ....
  79. Effects of Initial Graft Tension on ACL Reconstruction
    Braden Fleming; Fiscal Year: 2007
    ..54 subjects will serve in each experimental group and they will be followed for a minimum of 3-years. ..
  80. In vivo multichannel fluorescent imaging
    Umar Mahmood; Fiscal Year: 2004
    ....
  81. Effects of Initial Graft Tension on ACL Reconstruction
    Braden Fleming; Fiscal Year: 2006
    ..54 subjects will serve in each experimental group and they will be followed for a minimum of 3-years. ..
  82. Effects of Initial Graft Tension on ACL Reconstruction
    Braden Fleming; Fiscal Year: 2005
    ..54 subjects will serve in each experimental group and they will be followed for a minimum of 3-years. ..
  83. Cardiac MRI with 3D Undersampled Radial Imaging
    DANA PETERS; Fiscal Year: 2007
    ..The high resolution 3D radial viability technique will be validated in animals, and also used in patients. ..
  84. In vivo multichannel fluorescent imaging
    Umar Mahmood; Fiscal Year: 2007
    ....
  85. COMBINING NEUROIMAGING AND GENETICS FOR HERITABILITY MEASUREMENTS
    Peter Kochunov; Fiscal Year: 2007
    ..In addition to generating valuable, new data, this project will allow Peter Kochunov to undertake rigorous training in analytical genomics and accumulate first hand experience in executing genomic studies. ..
  86. Osteoarthritis following ACL reconstruction
    Braden Fleming; Fiscal Year: 2007
    ..abstract_text> ..
  87. Longitudinal Study of Predictors and Consequences of Chronic Kidney Disease
    Brad Astor; Fiscal Year: 2008
    ..In addition, it will provide much-needed data to be shared with the larger scientific community on serologic and genetic risk factors for CKD, a growing public health concern in the US. ..
  88. Effects of Initial Graft Tension on ACL Reconstruction
    Braden Fleming; Fiscal Year: 2004
    ..54 subjects will serve in each experimental group and they will be followed for a minimum of 3-years. ..
  89. In vivo multichannel fluorescent imaging
    Umar Mahmood; Fiscal Year: 2006
    ....
  90. Longitudinal Study of Predictors and Consequences of Chronic Kidney Disease
    Brad Astor; Fiscal Year: 2007
    ..In addition, it will provide much-needed data to be shared with the larger scientific community on serologic and genetic risk factors for CKD, a growing public health concern in the US. ..
  91. Effects of Initial Graft Tension on ACL Reconstruction
    Braden Fleming; Fiscal Year: 2003
    ..54 subjects will serve in each experimental group and they will be followed for a minimum of 3-years. ..
  92. BREATH HOLD 3D MRA OF THE CORONARY ARTERIES
    Robert Edelman; Fiscal Year: 2002
    ..The goal is to optimize the MRA method and to determine if the use of contrast agents provides any clinical benefit. ..
  93. Assessment of BBB Disruption during RT using DCE MRI
    Yue Cao; Fiscal Year: 2006
    ..Data from these scans will be analyzed to quantify vascular permeability, which related to dose, volume, time, and presence in tumor versus normal brain tissue. ..
  94. Magnetic Resonance Imaging of Cardiomyocyte Apoptosis
    David Sosnovik; Fiscal Year: 2007
    ..The proposed research also has the potential to facilitate a greater understanding of cardiomyocyte apoptosis and accelerate the development of novel cardioprotective strategies. ..
  95. VALIDATION OF MAGNETIC RESONANCE PERFUSION IMAGING
    Jeffry Alger; Fiscal Year: 2001
    ..UCLA has new state-of-the-art MRI and PET imaging devices together with active collaborating teams having expertise in stroke clinical management (both acute and rehabilitative), in MRI scanning and in PET scanning. ..
  96. VALIDATION OF MAGNETIC RESONANCE PERFUSION IMAGING
    Jeffry Alger; Fiscal Year: 2000
    ..UCLA has new state-of-the-art MRI and PET imaging devices together with active collaborating teams having expertise in stroke clinical management (both acute and rehabilitative), in MRI scanning and in PET scanning. ..
  97. Iron and Atherosclerosis
    Subha Raman; Fiscal Year: 2006
    ..Subgroup analyses will include comparison of the presence of iron symptomatic versus asymptomatic patients and women versus age-matched men. ..
  98. In vivo Dynamic Imaging of Angiogenesis in Transplanted Islets
    Eba Hathout; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  99. Cortical Inhibition During Visual Perception in Migraine
    Yue Cao; Fiscal Year: 2002
    ..Furthermore, the scientific concept proposed here may lead to an innovative approach to investigate visual function/dysfunction in migraine, and may provide a new insight into migraine pathophysiology. ..