neostigmine

Summary

Summary: A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.

Top Publications

  1. ncbi Antagonism of neuromuscular blockade but not muscle relaxation affects depth of anaesthesia
    F C Vasella
    Department of Anaesthesiology, University Hospital, CHUV BH 10, 1011 Lausanne, Switzerland
    Br J Anaesth 94:742-7. 2005
  2. ncbi Sugammadex reversal of rocuronium-induced neuromuscular blockade: a comparison with neostigmine-glycopyrrolate and edrophonium-atropine
    Ozlem Sacan
    Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9068, USA
    Anesth Analg 104:569-74. 2007
  3. pmc Unwarranted administration of acetylcholinesterase inhibitors can impair genioglossus and diaphragm muscle function
    Matthias Eikermann
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02114 2696, USA
    Anesthesiology 107:621-9. 2007
  4. doi Calcium and neostigmine antagonize gentamicin, but augment clindamycin-induced tetanic fade in rat phrenic nerve-hemidiaphragm preparations
    Soo Il Lee
    Department of Anesthesiology and Pain Medicine, Dong A University Medical Center and Medicine College, 1, 3 Ka, Dongdaeshin Dong, Seo Gu, Busan, 602 715, Korea
    J Anesth 22:385-90. 2008
  5. ncbi Evaluation for the interaction between intrathecal melatonin and clonidine or neostigmine on formalin-induced nociception
    Myung Ha Yoon
    Department of Anesthesiology and Pain Medicine, Chonnam National University, Medical School, 8 Hakdong, Donggu, Gwangju 501 757, Republic of Korea
    Life Sci 83:845-50. 2008
  6. ncbi The effect of dexamethasone on postoperative pain and emesis after intrathecal neostigmine
    P H Tan
    Department of Anesthesia, Chang Gung Memorial Hospital, Kaohsiung
    Anesth Analg 92:228-32. 2001
  7. ncbi Dose-response effects of spinal neostigmine added to bupivacaine spinal anesthesia in volunteers
    S S Liu
    Department of Anesthesiology, Virginia Mason Medical Center and the University of Washington, Seattle 98111, USA
    Anesthesiology 90:710-7. 1999
  8. doi Role of neostigmine and polyvalent antivenom in Indian common krait (Bungarus caeruleus) bite
    A Anil
    Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    J Infect Public Health 3:83-7. 2010
  9. ncbi Retrospective study of neostigmine for the treatment of acute colonic pseudo-obstruction
    B J Abeyta
    Department of Surgery, University of New Mexico, Albuquerque 87131, USA
    Am Surg 67:265-8; discussion 268-9. 2001
  10. ncbi Factors predicting successful outcome following neostigmine therapy in acute colonic pseudo-obstruction: a prospective study
    Rajiv Mehta
    Department of Gastroenterology, Amrita Institute of Medical Sciences, Cochin, Kerala, India
    J Gastroenterol Hepatol 21:459-61. 2006

Detail Information

Publications215 found, 100 shown here

  1. ncbi Antagonism of neuromuscular blockade but not muscle relaxation affects depth of anaesthesia
    F C Vasella
    Department of Anaesthesiology, University Hospital, CHUV BH 10, 1011 Lausanne, Switzerland
    Br J Anaesth 94:742-7. 2005
    ..Therefore we evaluated the effect of atracurium and neostigmine on bispectral index (BIS) and middle-latency auditory evoked potentials (AAI).
  2. ncbi Sugammadex reversal of rocuronium-induced neuromuscular blockade: a comparison with neostigmine-glycopyrrolate and edrophonium-atropine
    Ozlem Sacan
    Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9068, USA
    Anesth Analg 104:569-74. 2007
    ..We tested the hypothesis that sugammadex would provide for a more rapid reversal of a moderately profound residual rocuronium-induced blockade than the commonly used cholinesterase inhibitors, edrophonium and neostigmine.
  3. pmc Unwarranted administration of acetylcholinesterase inhibitors can impair genioglossus and diaphragm muscle function
    Matthias Eikermann
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02114 2696, USA
    Anesthesiology 107:621-9. 2007
    It is standard practice to administer a cholinesterase inhibitor (e.g., neostigmine) at the end of a surgical case to reverse suspected effects of neuromuscular blocking agents regardless of whether such residual effects are present...
  4. doi Calcium and neostigmine antagonize gentamicin, but augment clindamycin-induced tetanic fade in rat phrenic nerve-hemidiaphragm preparations
    Soo Il Lee
    Department of Anesthesiology and Pain Medicine, Dong A University Medical Center and Medicine College, 1, 3 Ka, Dongdaeshin Dong, Seo Gu, Busan, 602 715, Korea
    J Anesth 22:385-90. 2008
    A reduction in acetylcholine release induced by gentamicin may limit neostigmine-induced increases in acetylcholine concentration in the neuromuscular junction...
  5. ncbi Evaluation for the interaction between intrathecal melatonin and clonidine or neostigmine on formalin-induced nociception
    Myung Ha Yoon
    Department of Anesthesiology and Pain Medicine, Chonnam National University, Medical School, 8 Hakdong, Donggu, Gwangju 501 757, Republic of Korea
    Life Sci 83:845-50. 2008
    We examined the nature of pharmacological interaction after coadministration of melatonin with clonidine or neostigmine on formalin-induced nociception at the spinal level...
  6. ncbi The effect of dexamethasone on postoperative pain and emesis after intrathecal neostigmine
    P H Tan
    Department of Anesthesia, Chang Gung Memorial Hospital, Kaohsiung
    Anesth Analg 92:228-32. 2001
    ..and severity of postoperative nausea and vomiting (PONV) after intrathecal injection of tetracaine plus neostigmine. Sixty ASA physical status I patients scheduled for inguinal herniorrhaphy were studied with a randomized, ..
  7. ncbi Dose-response effects of spinal neostigmine added to bupivacaine spinal anesthesia in volunteers
    S S Liu
    Department of Anesthesiology, Virginia Mason Medical Center and the University of Washington, Seattle 98111, USA
    Anesthesiology 90:710-7. 1999
    Intrathecal adjuncts often are used to enhance small-dose spinal bupivacaine for ambulatory anesthesia. Neostigmine is a novel spinal analgesic that could be a useful adjunct, but no data exist to assess the effects of neostigmine on ..
  8. doi Role of neostigmine and polyvalent antivenom in Indian common krait (Bungarus caeruleus) bite
    A Anil
    Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    J Infect Public Health 3:83-7. 2010
    ..This study was undertaken to find the effectiveness of neostigmine and polyvalent antivenom in improving neuromuscular paralysis following bite...
  9. ncbi Retrospective study of neostigmine for the treatment of acute colonic pseudo-obstruction
    B J Abeyta
    Department of Surgery, University of New Mexico, Albuquerque 87131, USA
    Am Surg 67:265-8; discussion 268-9. 2001
    ..Studies suggest that pharmacologic manipulation with intravenous (i.v.) neostigmine (NSM) may be an effective and less invasive treatment modality for ACPO with minimal side effects...
  10. ncbi Factors predicting successful outcome following neostigmine therapy in acute colonic pseudo-obstruction: a prospective study
    Rajiv Mehta
    Department of Gastroenterology, Amrita Institute of Medical Sciences, Cochin, Kerala, India
    J Gastroenterol Hepatol 21:459-61. 2006
    To evaluate predictors of neostigmine response in patients with acute colonic pseudo-obstruction.
  11. ncbi Neostigmine resolves critical illness-related colonic ileus in intensive care patients with multiple organ failure--a prospective, double-blind, placebo-controlled trial
    J I van der Spoel
    Intensive Care Unit, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
    Intensive Care Med 27:822-7. 2001
    ..as a result of the absence of prokinetic movements of the colon, while the upper gastrointestinal tract functions properly and mechanical ileus is absent: We investigated whether neostigmine resulted in defecation in patients with CIRCI.
  12. pmc Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study
    Martina Grosse-Sundrup
    Department of Anaesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA
    BMJ 345:e6329. 2012
    ..To determine whether use of intermediate acting neuromuscular blocking agents during general anesthesia increases the incidence of postoperative respiratory complications...
  13. ncbi Reversal of rocuronium-induced neuromuscular blockade with sugammadex compared with neostigmine during sevoflurane anaesthesia: results of a randomised, controlled trial
    Manfred Blobner
    Klinik für Anästhesiologie der Technischen Universität München, Munich, Germany
    Eur J Anaesthesiol 27:874-81. 2010
    ..This study compared the efficacy of sugammadex and neostigmine for reversal of neuromuscular blockade induced by rocuronium for facilitating elective surgery.
  14. ncbi Cardiac arrest complicating neostigmine use for bowel opening in a critically ill patient
    Lesley Maher
    Intensive Care Unit, Wellington Regional Hospital, Wellington, New Zealand
    Crit Care Resusc 13:192-3. 2011
    Absence of bowel opening is common among critically ill patients. Neostigmine can be used to achieve stool passage after other treatments have been ineffective...
  15. ncbi The antinociceptive effect of intrathecal administration of epibatidine with clonidine or neostigmine in the formalin test in rats
    A T Hama
    Merck Research Laboratories, San Diego, 505 Coast Blvd South, 300, La Jolla CA 92037, USA
    Pain 91:131-8. 2001
    The analgesic effect of intrathecal injection of epibatidine, clonidine and neostigmine, compounds that elevate ACh, was examined in the formalin test, a model of post-injury central sensitization in the rat...
  16. ncbi Antinociceptive effect of low-dose intrathecal neostigmine combined with intrathecal morphine following gynecologic surgery
    Raquel A Almeida
    Hospital das Clinicas, Department of Biomechanics, Medicine and Rehabilitation, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
    Anesthesiology 98:495-8. 2003
    The purpose of this study was to determine whether combination of 1-5 microg intrathecal neostigmine would enhance analgesia from a fixed intrathecal dose of morphine.
  17. pmc Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine
    Qian sheng Yu
    Drug Design and Development Section, Laboratory of Neurosciences, Biomedical Research Center, National Institute on Aging, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA
    Bioorg Med Chem 18:4687-93. 2010
    The N-monophenylcarbamate analogues of neostigmine methyl sulfate (6) and pyridostigmine bromide (8) together with their precursors (5), (7), and the N(1)-methylammonium analogues of (-)-phenserine (12), (-)-tolserine (14), (-)-cymserine ..
  18. ncbi The effect of neostigmine on postoperative ileus and the healing of colon anastomoses
    M Emirleroglu
    Yeditepe University Hospital, Department of General Surgery, Istanbul, Turkey
    Bratisl Lek Listy 112:309-13. 2011
    The aim of this study was to assess the effects of neostigmine on the postoperative ileus and the healing of colon anastomoses.
  19. ncbi Assessment of predictors of response to neostigmine for acute colonic pseudo-obstruction
    Conor G Loftus
    Division of Gastroenterology and Hepatology, Mayo Medical Center, Rochester, Minnesota, USA
    Am J Gastroenterol 97:3118-22. 2002
    ..Colonoscopic decompression may be required in patients failing to respond to conservative treatment. Neostigmine has been proposed as an effective treatment for ACPO as an alternative to colonoscopic decompression...
  20. pmc Neostigmine for the treatment of acute hepatic encephalopathy with acute intestinal pseudo-obstruction in a cirrhotic patient
    Chang Hwan Park
    Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea
    J Korean Med Sci 20:150-2. 2005
    We treated a 49-yr-old man with neostigmine, who had liver cirrhosis, acute hepatic encephalopathy, and acute intestinal pseudoobstruction. He was admitted in a state of hepatic confusion...
  21. doi Efficacy of bupivacaine-neostigmine and bupivacaine-tramadol in caudal block in pediatric inguinal herniorrhaphy
    Reza Taheri
    Department of Anesthesiology, Children s Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
    Paediatr Anaesth 20:866-72. 2010
    ..Therefore, the purpose of this study was to evaluate the effectiveness and safety of bupivacaine in combination with either neostigmine or tramadol for caudal block in children undergoing inguinal herniorrhaphy.
  22. ncbi Neostigmine combined with bupivacaine, clonidine, and sufentanil for spinal labor analgesia
    R D'ANGELO
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27103, USA
    Anesth Analg 93:1560-4, table of contents. 2001
    ..We sought to determine whether the addition of spinal neostigmine to these drugs would further enhance labor analgesia...
  23. ncbi Assessment of the effects of erythromycin, neostigmine, and metoclopramide on abomasal motility and emptying rate in calves
    Thomas Wittek
    Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802, USA
    Am J Vet Res 66:545-52. 2005
    To determine and compare the effects of erythromycin, neostigmine, and metoclopramide on abomasal motility and emptying rate in suckling calves.
  24. ncbi Intrathecal bupivacaine with morphine or neostigmine for postoperative analgesia after total knee replacement surgery
    P H Tan
    Department of Anesthesia, Chang Gung Memorial Hospital, Kaohsiung, Taiwan, Republic of China
    Can J Anaesth 48:551-6. 2001
    To compare the postoperative analgesic efficacy and safety of intrathecal (IT) neostigmine and IT morphine in patients undergoing total knee replacement under spinal anesthesia.
  25. ncbi A prospective randomized double-blind study to determine the effect of thoracic epidural neostigmine on postoperative ileus after abdominal aortic surgery
    Esra Caliskan
    Baskent University, Faculty of Medicine, Adana Teaching and Medical Research Center, Department of Anesthesiology and Reanimation, Dadaloglu Mahallesi, 39 Sokak, No 36, Yuregir 01250 Adana, Turkey
    Anesth Analg 106:959-64, table of contents. 2008
    ..In this study, we evaluated the effect of epidurally administered neostigmine on postoperative ileus after abdominal aortic surgery.
  26. ncbi Correlations between acetylcholinesterase inhibition, acetylcholine levels and EEG changes during perfusion with neostigmine and N6-cyclopentyladenosine in rat brain
    Marloes J A Joosen
    TNO Defence, Security and Safety, BU Biological and Chemical Protection, Department Diagnosis and Therapy, Rijswijk, The Netherlands
    Eur J Pharmacol 555:122-8. 2007
    ..EEG) changes was investigated during local perfusion of the reversible acetylcholinesterase inhibitor neostigmine in the hippocampus and striatum of freely moving rats...
  27. ncbi Electroacupuncture potentiates the antiallodynic effect of intrathecal neostigmine in a rat model of neuropathic pain
    Ha Neul Kim
    Department of East West Medicine, Graduate School, Kyung Hee University, Seoul, South Korea
    J Physiol Sci 58:357-60. 2008
    This study was performed to examine whether electroacupuncture potentiates the neostigmine-induced antiallodynia in neuropathic pain rats. Although intrathecal neostigmine (0.05, 0.1, and 0...
  28. doi The effects of neostigmine and glycopyrrolate on skin conductance as a measure of pain
    Thomas Ledowski
    Anaesthesiology Unit, School of Medicine and Pharmacology, The University of Western Australia, Perth, Western Australia, Australia
    Eur J Anaesthesiol 26:777-81. 2009
    ..In this context, the effects of cholinesterase inhibitors and anticholinergic drugs used for the reversal of muscle relaxants were investigated...
  29. doi Postoperative analgesic effects of epidural administration of neostigmine alone or in combination with morphine in ovariohysterectomized dogs
    Rodrigo L Marucio
    Department of Veterinary Surgery and Anesthesiology, Faculdade de Medicina Veterinaria e Zootecnia, Universidade Estadual Paulista, Botucatu, Sao Paulo, Brazil, 14870 000
    Am J Vet Res 69:854-60. 2008
    To evaluate analgesic effects of epidurally administered neostigmine alone or in combination with morphine in dogs after ovariohysterectomy. Animals-40 healthy bitches.
  30. ncbi Neostigmine/glycopyrrolate administered after recovery from neuromuscular block increases upper airway collapsibility by decreasing genioglossus muscle activity in response to negative pharyngeal pressure
    Frank Herbstreit
    Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Essen, Germany
    Anesthesiology 113:1280-8. 2010
    Reversal of residual neuromuscular blockade by acetylcholinesterase inhibitors (e.g., neostigmine) improves respiratory function. However, neostigmine may also impair muscle strength...
  31. ncbi Neostigmine: an alternative treatment for constipation
    Anne Fu
    York Central Hospital, Richmond Hill, Ontario
    Dynamics 16:13-5. 2005
    ..Recent studies have shown neostigmine may be an effective treatment for ACPO...
  32. ncbi Phase I human safety assessment of intrathecal neostigmine containing methyl- and propylparabens
    J C Eisenach
    Department of Anesthesia, Bowman Gray School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesth Analg 85:842-6. 1997
    Intrathecal (i.t.) neostigmine produces analgesia in humans with acute experimental, postoperative, and chronic pain...
  33. ncbi Determinants of the reversal time of competitive neuromuscular block by anticholinesterases
    G H Beemer
    Anaesthesia Department, Royal Melbourne Hospital, Victoria, Australia
    Br J Anaesth 66:469-75. 1991
    ..block by anticholinesterase when alcuronium and atracurium neuromuscular block were antagonized by neostigmine 0.04 and 0.08 mg kg-1 and edrophonium 0.5 and 1.0 mg kg-1...
  34. ncbi Intrathecal neostigmine reduces the zymosan-induced inflammatory response in a mouse air pouch model via adrenomedullary activity: involvement of spinal muscarinic type 2 receptors
    Seo Yeon Yoon
    Department of Veterinary Physiology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Seoul, South Korea
    Neuropharmacology 49:275-82. 2005
    Intrathecal (IT) injection of neostigmine (a cholinesterase inhibitor) has been reported to produce a significant anti-nociceptive effect in a number of inflammatory pain models...
  35. pmc Sugammadex compared with neostigmine/glycopyrrolate for routine reversal of neuromuscular block: a systematic review and economic evaluation
    F Paton
    Centre for Reviews and Dissemination, University of York, Heslington, York YO10 5DD, UK
    Br J Anaesth 105:558-67. 2010
    ..We performed a systematic review of randomized controlled trials of sugammadex compared with neostigmine/glycopyrrolate and an economic assessment of sugammadex for the reversal of moderate or profound neuromuscular ..
  36. ncbi Effects of atropine sulfate and neostigmine on gastric electrical activity in human subjects--electrogastrographic study
    Kenji Imai
    Department of Clinical Acupuncture and Moxibustion II, Meiji University of Oriental Medicine, Hiyoshi cho, Kyoto, Japan
    Hepatogastroenterology 55:294-7. 2008
    ..To determine the effect of intravenous administration of a vagal blocker (atropine sulfate) or a vagal stimulator (neostigmine) on gastric electrical activities EGG was utilized in this study.
  37. ncbi Neostigmine increases postoperative colonic motility in patients undergoing colorectal surgery
    M E Kreis
    Department of General Surgery, University Hospital, , Germany
    Surgery 130:449-56. 2001
    ..We investigated the effects of neostigmine on colonic motility in patients after colorectal surgery and in healthy volunteers...
  38. ncbi Effect of neostigmine on organ injury in murine endotoxemia: missing facts about the cholinergic antiinflammatory pathway
    Seda B Akinci
    Department of Anaesthesiology and Reanimation, Hacettepe University Faculty of Medicine, Sihhiye, Ankara 06100, Turkey
    World J Surg 29:1483-9. 2005
    ..b>Neostigmine, a cholinergic agent, has not been tested to determine if it can prevent histopathologic organ injury in ..
  39. ncbi Intravenous regional anesthesia using prilocaine and neostigmine
    A Turan
    Department of Anaesthesiology and Reanimation, Medical Faculty, Trakya University, 22030 Edirne, Turkey
    Anesth Analg 95:1419-22, table of contents. 2002
    b>Neostigmine has been added to local anesthetics for central and peripheral nerve blocks resulting in prolonged, increased anesthesia and improved analgesia...
  40. ncbi Analgesic effects of intrathecal neostigmine in perianal surgery
    A Yegin
    Akdeniz University Faculty of Medicine, Department of Anaesthesiology, Antalya, Turkey
    Eur J Anaesthesiol 20:404-8. 2003
    In recent human and animal studies, intrathecal administration of various doses of neostigmine produces analgesia without neurotoxicity...
  41. ncbi Treatment of anticholinergic-induced ileus with neostigmine
    G K Isbister
    Department of Clinical Toxicology and Pharmacology, Newcastle Mater Hospital, Newcastle, New South Wales, Australia
    Ann Emerg Med 38:689-93. 2001
    ..Persistent ileus was treated with repeated doses of neostigmine, and gastrointestinal motility returned with prompt defecation...
  42. doi Antagonism of low degrees of atracurium-induced neuromuscular blockade: dose-effect relationship for neostigmine
    Thomas Fuchs-Buder
    Department of Anesthesia and Critical Care, Centre Hospitalier Universitaire, Institut de la Sante et de la Recherche Medicale, CIC EC CIE6, Nancy, France
    Anesthesiology 112:34-40. 2010
    ..This may be of clinical interest because a high dose of neostigmine given at a shallow level of neuromuscular block may produce neuromuscular weakness...
  43. ncbi A multi-center study of intrathecal neostigmine for analgesia following vaginal hysterectomy
    G R Lauretti
    Department of Surgery, Orthopedics and Traumatology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
    Anesthesiology 89:913-8. 1998
    Intrathecal neostigmine injection produces analgesia in volunteers and reduces hypotension from intrathecal bupivacaine in animals...
  44. doi Reversal of rocuronium-induced neuromuscular block with sugammadex is faster than reversal of cisatracurium-induced block with neostigmine
    E A Flockton
    University Department of Anaesthesia, School of Clinical Sciences, Duncan Building, Daulby Street, Liverpool L69 3GA, UK
    Br J Anaesth 100:622-30. 2008
    Reversal of the residual effect of rocuronium or cisatracurium by neostigmine may be slow and associated with side-effects...
  45. doi Ultrasonographic assessment of the reticular motility in cows after administration of different doses of metoclopramide and neostigmine
    Sabry A El-Khodery
    Department of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt
    Vet Res Commun 32:473-80. 2008
    ..ultrasonography for assessment of reticular motility after administration of various doses of metclopramide and neostigmine in cows. A total of ten Holstein cows were used in six trials in each one single dose of each drug was used...
  46. doi Sugammadex provides faster reversal of vecuronium-induced neuromuscular blockade compared with neostigmine: a multicenter, randomized, controlled trial
    Karin S Khuenl-Brady
    Medical University Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Anesth Analg 110:64-73. 2010
    ..In this study, we compared the efficacy of sugammadex and neostigmine for the reversal of vecuronium-induced neuromuscular blockade in patients scheduled for elective surgery.
  47. ncbi The effect of epidural neostigmine combined with ropivacaine and sufentanil on neuraxial analgesia during labor
    Fabienne Roelants
    Department of Anesthesiology, Universite Catholique de Louvain, St Luc Hospital, Avenue Hippocrate 10 1820, 1200 Brussels, Belgium
    Anesth Analg 96:1161-6, table of contents. 2003
    Spinal neostigmine produces analgesia without respiratory depression or hypotension but provokes major gastrointestinal side effects. Epidural injection of this drug, however, appears to induce analgesia devoid of such side effects...
  48. ncbi Caudal ropivacaine and neostigmine in pediatric surgery
    Alparslan Turan
    Department of Anesthesiology, Trakya University Medical Faculty, Edirne, Turkey
    Anesthesiology 98:719-22. 2003
    b>Neostigmine has been added to local anesthetics for different nerve blocks. This study was conducted to evaluate effects of neostigmine when added to ropivacaine for caudal anesthesia.
  49. ncbi Rewarding effects of the cholinergic agents carbachol and neostigmine in the posterior ventral tegmental area
    Satoshi Ikemoto
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurosci 22:9895-904. 2002
    ..of the cholinergic agonist carbachol (30-500 pmol per infusion) or the acetylcholinesterase inhibitor neostigmine (7.5-75 pmol per infusion) into the posterior ventral tegmental area (VTA) of the brain...
  50. doi Acute colonic pseudoobstruction in a child with sickle cell disease treated with neostigmine
    Arjun Khosla
    Division of Pediatric Surgery, Rainbow Babies and Children s Hospital, Case Western Reserve University, Cleveland, OH 44106, USA
    J Pediatr Surg 43:2281-4. 2008
    ..pediatric case of acute pseudoobstruction secondary to sickle cell disease that was treated successfully with neostigmine. Early recognition of this phenomenon is important as it alters patient management, can be treated medically, ..
  51. ncbi Pharmacologic interaction between cannabinoid and either clonidine or neostigmine in the rat formalin test
    Myung Ha Yoon
    Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, Gwanju, Korea
    Anesthesiology 99:701-7. 2003
    ..Spinal alpha 2 receptor agonist (clonidine) and cholinesterase inhibitor (neostigmine) are also active in the modulation of nociception...
  52. ncbi Epidural neostigmine produces analgesia but also sedation in women after cesarean delivery
    F Nur Kaya
    Departments of Anesthesiology, Uludag University, Bursa, Turkey
    Anesthesiology 100:381-5. 2004
    Intrathecal neostigmine produces analgesia but also nausea, limiting its utility. In contrast, epidural administration of neostigmine has been suggested to produce postoperative analgesia without nausea in nonpregnant patients...
  53. ncbi The use of neuraxial adjuvant drugs (neostigmine, clonidine) in obstetrics
    Fabienne Roelants
    Department of Anaesthesiology, Cliniques Universitaires Saint Luc, Brussels, Belgium
    Curr Opin Anaesthesiol 19:233-7. 2006
    ..Opioids are used in routinely, but alpha2-agonists, such as clonidine or cholinesterase inhibitors (neostigmine), have also been used for labour analgesia or to relieve pain following caesarean section...
  54. ncbi Characteristic of interactions between intrathecal gabapentin and either clonidine or neostigmine in the formalin test
    Myung Ha Yoon
    Department of Anesthesiology and Pain Medicine, Chonnam National University, Medical School, Gwangju, Korea
    Anesth Analg 98:1374-9, table of contents. 2004
    ..Unlike gabapentin, intrathecal clonidine and neostigmine attenuate both acute pain and phase 2 of the formalin response...
  55. ncbi Bronchospasm caused by neostigmine
    A Hazizaj
    Eur J Anaesthesiol 23:85-6. 2006
  56. ncbi The efficacy of thoracic epidural neostigmine infusion after thoracotomy
    Yuan Yi Chia
    Department of Anesthesiology, Kaohsiung Veterans General Hospital and School of Medicine, National Yang Ming University, Taiwan
    Anesth Analg 102:201-8. 2006
    Few anesthesia studies have explored perioperative continuous epidural infusion of neostigmine. We examined such a regimen in thoracotomy patients. Ninety patients were randomized to one of three groups in this double-blind trial...
  57. ncbi Caudal additives in pediatrics: a comparison among midazolam, ketamine, and neostigmine coadministered with bupivacaine
    P Kumar
    Department of Anaesthesiology, Calcutta National Medical College, Kolkata, India
    Anesth Analg 101:69-73, table of contents. 2005
    ..randomized double-blind clinical study, we assessed and compared the efficacy of ketamine, midazolam, and neostigmine coadministered with bupivacaine in a caudal epidural to provide intraoperative and postoperative pain relief...
  58. ncbi Acute colonic pseudo-obstruction in postchemotherapy complication of brain tumor treated with neostigmine
    Tai Sung Kim
    Department of Pediatrics, Division of Pediatric Hematology Oncology, St Mary s Hospital, The Catholic University of Korea, Seoul, Korea
    J Pediatr Hematol Oncol 29:420-2. 2007
    ..We report a 9-year-old boy with acute colonic pseudo-obstruction caused by chemotherapy for brain tumor who did not respond to initial supportive therapy, but who was successfully treated with neostigmine.
  59. ncbi Tetrodotoxin poisoning: a clinical analysis, role of neostigmine and short-term outcome of 53 cases
    F R Chowdhury
    Department of Neuro Medicine, Bangabandhu Shaikh Mujib Medical University, Dhaka, Bangladesh
    Singapore Med J 48:830-3. 2007
    ..In this paper, we aim to share our experience and to find out the toxic manifestations, lag period between ingestion of fish and development of symptoms, the short-term clinical outcome, and value of neostigmine in its management.
  60. ncbi Epidural administration of neostigmine and clonidine to induce labor analgesia: evaluation of efficacy and local anesthetic-sparing effect
    Fabienne Roelants
    Department of Anesthesiology, Universite Catholique de Louvain, St Luc Hospital, Avenue Hippocrate 10 1820, 1200 Brussels, Belgium
    Anesthesiology 102:1205-10. 2005
    ..The authors have recently demonstrated that epidural neostigmine initiates selective labor analgesia devoid of adverse effects...
  61. ncbi Acute colonic pseudo-obstruction: rapid correction with neostigmine in the emergency department
    Robert McNamara
    Department of Emergency Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Emerg Med 35:167-70. 2008
    ..A diagnosis of acute colonic pseudo-obstruction was made and 2 mg of intravenous neostigmine was administered, with resolution of the patient's condition allowing for subsequent Emergency Department ..
  62. ncbi Neostigmine but not sugammadex impairs upper airway dilator muscle activity and breathing
    M Eikermann
    Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Br J Anaesth 101:344-9. 2008
    ..Sugammadex reverses neuromuscular block by encapsulating rocuronium. However, its effects on upper airway integrity and breathing are unknown...
  63. ncbi Reversal of profound rocuronium-induced blockade with sugammadex: a randomized comparison with neostigmine
    R Kevin Jones
    Accurate Clinical Trials Saddleback Memorial Medical Center, Laguna Hills, CA 92653, USA
    Anesthesiology 109:816-24. 2008
    ..Sugammadex is a novel reversal agent, reversing the effects of rocuronium by encapsulation. This study assessed the efficacy and safety of sugammadex versus neostigmine for reversal of profound rocuronium-induced neuromuscular blockade.
  64. ncbi Differential reversal of drug-induced small bowel paralysis by cerulein and neostigmine
    Sonja Fruhwald
    Department of Anaesthesiology and Intensive Care Medicine, University of Graz, Auenbruggerplatz 29, 8036 Graz, Austria
    Intensive Care Med 30:1414-20. 2004
    Cerulein and neostigmine are prokinetic drugs whose potency and effective dose range are barely known. The aim of this study was to assess their benefit for normal and compromised peristalsis.
  65. ncbi Dose response study of caudal neostigmine for postoperative analgesia in paediatric patients undergoing genitourinary surgery
    Y K Batra
    Department of Anaesthesia and Intensive Care, Postgraduate Institute of Medical Education and Research PGIMER, Chandigarh, India
    Paediatr Anaesth 13:515-21. 2003
    b>Neostigmine given through the neuraxial route has been found to have analgesic properties...
  66. ncbi Ogilvie's syndrome in acute myeloid leukemia: pharmacological approach with neostigmine
    M Breccia
    Dipartimento di Biotecnologie Cellulari ed Ematologia, University La Sapienza, Rome, Italy
    Ann Hematol 80:614-6. 2001
    ..This process was associated with sepsis and resolved with conservative therapy of the underlying condition, using granulocyte colony-stimulating factor and intravenous neostigmine. We discuss the management of this rare syndrome.
  67. ncbi Analgesic effect of epidural neostigmine after abdominal hysterectomy
    M Nakayama
    Department of Anesthesiology, Obihiro Kosei Hospital, Obihiro, Japan
    J Clin Anesth 13:86-9. 2001
    To evaluate the effects of epidurally administered neostigmine on pain after abdominal hysterectomy.
  68. ncbi Neostigmine antagonism of rocuronium block during anesthesia with sevoflurane, isoflurane or propofol
    J E Reid
    Department of Anaesthetics and Intensive Care Medicine, The Queen's University of Belfast, N. Ireland, UK
    Can J Anaesth 48:351-5. 2001
    ..administration of sevoflurane or isoflurane during reversal of rocuronium induced neuromuscular block with neostigmine. METHODS: One hundred and twenty patients, divided into three equal groups, were randomly allocated to ..
  69. ncbi Low-dose clonidine and neostigmine prolong the duration of intrathecal bupivacaine-fentanyl for labor analgesia
    M D Owen
    Wake Forest University Department of Anesthesiology, Section on Obstetric Anesthesia, Winston Salem, North Carolina, USA
    Anesthesiology 92:361-6. 2000
    ..This study was undertaken to determine whether the addition of clonidine and neostigmine to IT bupivacaine-fentanyl would increase the duration of analgesia without increasing side effects for ..
  70. ncbi The interaction between intrathecal neostigmine and GABA receptor agonists in rats with nerve ligation Injury
    J H Hwang
    Department of Anesthesiology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Korea
    Anesth Analg 93:1297-303. 2001
    ..We examined the drug interactions between neostigmine and muscimol or baclofen in a rat model of nerve ligation injury...
  71. pmc Synergistic effects between intrathecal clonidine and neostigmine in the formalin test
    M H Yoon
    Department of Anesthesiology, Chonnam National University, Medical School, Dong Gu, Kwangju, Korea
    J Korean Med Sci 16:498-504. 2001
    ..Both intrathecal clonidine and neostigmine dose-dependently suppressed the flinching during phase 1 and phase 2...
  72. ncbi Central and peripheral analgesia mediated by the acetylcholinesterase-inhibitor neostigmine in the rat inflamed knee joint model
    H Buerkle
    Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Westfalische Wilhelms Universitat Munster, Germany
    Anesth Analg 86:1027-32. 1998
    ..The use of intrathecal (i.t.) acetylcholinesterase-inhibitors, such as neostigmine, result in analgesia in both preclinical and clinical models. However, whether i.t...
  73. ncbi The efficacy of intrathecal neostigmine, intrathecal morphine, and their combination for post-cesarean section analgesia
    C J Chung
    Department of Anesthesiology, College of Medicine, Dong A University, Pusan, Korea
    Anesth Analg 87:341-6. 1998
    We designed this study to evaluate the postoperative analgesic efficacy and safety of intrathecal (i.t.) neostigmine, i.t. morphine, and their combination in patients undergoing cesarean section under spinal anesthesia...
  74. ncbi Antinociceptive effect of intrathecal neostigmine evaluated in rats by two different pain models
    W A Prado
    Departamento de Farmacologia, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Brasil
    Braz J Med Biol Res 30:1225-31. 1997
    ..The antinociceptive effect of intraspinal neostigmine was examined in rats submitted concurrently to the tail flick and formalin tests. Neostigmine (8.25 and 16...
  75. ncbi Neostigmine and polyethylene glycol electrolyte solution for the therapy of acute hepatic encephalopathy with liver cirrhosis and ascites
    Takayoshi Kiba
    Third Department of Internal Medicine, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236, Japan
    Hepatogastroenterology 50:823-6. 2003
    ..man who had non-B and non-C, and Child's class C liver cirrhosis and acute hepatic encephalopathy with neostigmine and polyethylene glycol electrolyte solution...
  76. ncbi Amitraz: an unusual aetiology of Ogilvie's syndrome
    Sahin Aslan
    Department of Emergency Medicine, Ataturk University, School of Medicine, Erzurum, Turkey
    Hum Exp Toxicol 24:481-3. 2005
    ..Amitraz is an insecticide/acaricide of formamidine pesticides used worldwide for ectoparasites in animals. Because of its widespread use, amitraz poisoning is frequently encountered in Turkey...
  77. ncbi [Stopping smoking and constipation]
    Gilbert Lagrue
    Hopital Albert Chenevier, Creteil
    Presse Med 35:246-8. 2006
    ..Among the symptoms that may occur with smoking withdrawal, constipation is relatively frequent, but little studied...
  78. ncbi Microdialysis measures of functional increases in ACh release in the hippocampus with and without inclusion of acetylcholinesterase inhibitors in the perfusate
    Qing Chang
    Department of Psychology and the Neuroscience Program, University of Illinois at Urbana Champaign, Champaign, Illinois 61820, USA
    J Neurochem 97:697-706. 2006
    ..levels are near detection limits in microdialysis samples, an acetylcholinesterase (AChE) inhibitor such as neostigmine is often added to microdialysis perfusates to increase ACh levels in the dialysate, a practice that raises ..
  79. ncbi Postoperative delirium and Ogilvie's syndrome resolving with neostigmine
    Azadeh Lankarani-Fard
    J Am Geriatr Soc 54:1016-7. 2006
  80. ncbi [A plastic property in the change of rat muscle potentials clarified in the presence of neostigmine: a conjecture on the recycling process of ACh]
    I Uramoto
    Department of Physiology, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi 480-0392, Japan
    Nippon Seirigaku Zasshi 63:102-10. 2001
    ..was evaluated in terms of muscle potentials evoked by a set of 10 stimuli in the presence and the absence of neostigmine using Wistar rats anesthetized with urethane...
  81. ncbi Coronary vasospasm during the reversal of neuromuscular block using neostigmine
    K Kido
    Acta Anaesthesiol Scand 49:1395-6. 2005
  82. ncbi Neostigmine added to lidocaine axillary plexus block for postoperative analgesia
    A C Van Elstraete
    Department of Anaesthesiology, Saint-Paul Medical Center, University Hospital, Fort-de-France, Martinique, France
    Eur J Anaesthesiol 18:257-60. 2001
    BACKGROUND: AND OBJECTIVE: We have assessed the analgesic efficacy and side-effects of neostigmine when added to lidocaine for axillary brachial plexus block, in a prospective, randomized, double-blind, placebo-controlled study...
  83. ncbi Ventricular fibrillation following atropine-neostigmine mixture in a patient with undiagnosed mitral valve prolapse
    A Zeidan
    Anaesthesia 60:724-5. 2005
  84. ncbi The diacylglycerol lipase inhibitor RHC-80267 potentiates the relaxation to acetylcholine in rat mesenteric artery by anti-cholinesterase action
    Philippe Ghisdal
    Laboratoire de Pharmacologie expérimentale Université Catholique de Louvain UCL 5410 Avenue Hippocrate, 54 B 1200 Bruxelles, Belgium
    Eur J Pharmacol 517:97-102. 2005
    ..b>Neostigmine, a cholinesterase inhibitor, produced the same effect as RHC-80267 on acetylcholine-evoked relaxation...
  85. ncbi Residual paralysis at the time of tracheal extubation
    Glenn S Murphy
    Department of Anesthesiology, Evanston Northwestern Healthcare, 2650 Ridge Ave, Evanston, IL 60201, USA
    Anesth Analg 100:1840-5. 2005
    ..was maintained with rocuronium (visual train-of-four [TOF] count of 2) and all subjects were reversed with neostigmine at a TOF count of 2-4...
  86. ncbi Involvement of the bed nucleus of the stria terminalis in hippocampal cholinergic system-mediated activation of the hypothalamo--pituitary--adrenocortical axis in rats
    W Zhu
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan
    Brain Res 916:101-6. 2001
    ..5 microg/microl of solution per side). Two weeks later, neostigmine was microinjected into the rats' hippocampus...
  87. ncbi Neostigmine-induced reversal of vecuronium in normal weight, overweight and obese female patients
    T Suzuki
    Department of Anaesthesiology, Surugadai Nihon University Hospital, 1 8 13, Kanda Surugadai, Chiyoda ku, Tokyo 101 8309, Japan
    Br J Anaesth 97:160-3. 2006
    The purpose of this study was to compare neostigmine-induced reversal of vecuronium in normal weight, overweight and obese female patients.
  88. ncbi Stimulation of the hippocampal glutamate receptor systems induces stress-like responses
    Hiroyuki Umegaki
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, 466 8550, Japan
    Neuro Endocrinol Lett 27:339-43. 2006
    ..We also studied the interactions between glutamate and acetylcholine in this response in the hippocampus...
  89. ncbi Heart block and prolonged Q-Tc interval following muscle relaxant reversal: a case report
    John A Shields
    Vanderbilt University Medical Center, Nashville, Tennessee, USA
    AANA J 76:41-5. 2008
    ..this article, heart block occurred and the Q-Tc interval became prolonged after muscle relaxant reversal with neostigmine; both were considered to be related to the combination of agents used in the case, as well as to other ..
  90. pmc Cholinergic innervation of the guinea-pig isolated vas deferens
    Pravesh Solanki
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK
    Naunyn Schmiedebergs Arch Pharmacol 376:265-74. 2007
    ..The bretylium-resistant component was potentiated by the acetylcholinesterase (AChE) inhibitor neostigmine (10 microM) and inhibited by the muscarinic-receptor (mAChR) antagonist cyclopentolate (1 microM)...
  91. ncbi Role of activation of cholinergic influences in recovery of electrical activity of the stomach and small intestine during the early postoperative period in rats
    N S Tropskaya
    N V Sklifosovsky Institute of Urgent Care, Moscow
    Bull Exp Biol Med 143:194-6. 2007
    The effects of neostigmine and calcium pantothenate on electrical activity of the stomach and small intestine were studied in chronic experiments on rats after laparotomy with implantation of a probe into the jejunum and electrodes into ..
  92. ncbi Cholinesterase activity is similar in C3H/HeJ and A/J mice and does not account for their different bronchoconstrictor responsiveness
    Y Bulut
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Exp Lung Res 25:367-78. 1999
    ..We asked if administration of neostigmine (an acetylcholinesterase inhibitor) and/or succinylcholine (an agent which competes for and inhibits ..
  93. ncbi The effect of neuromuscular block and noxious stimulation on hypnosis monitoring during sevoflurane anesthesia
    Andreas Ekman
    Department of Physiology and Pharmacology, Section for Anesthesiology and Intensive Care Medicine, Karolinska Institute, Stockholm, Sweden
    Anesth Analg 105:688-95. 2007
    ....
  94. ncbi Comparative in vivo effects of parathion on striatal acetylcholine accumulation in adult and aged rats
    Subramanya Karanth
    Department of Physiological Sciences, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, United States
    Toxicology 239:167-79. 2007
    ..synthesis or in vivo acetylcholine accumulation following direct infusion of the cholinesterase inhibitor neostigmine (1 microM) were noted...
  95. ncbi Sugammadex: a novel agent for the reversal of neuromuscular blockade
    Wayne T Nicholson
    Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Pharmacotherapy 27:1181-8. 2007
    ..It provides a novel mechanism of action for reversal of the neuromuscular block induced by nondepolarizing aminosteroidal agents...
  96. ncbi Acute colonic pseudo-obstruction
    Michael D Saunders
    Division of Gastroenterology, University of Washington Medical Center, 1959 Northeast Pacific Avenue, Suite AA103P, Box 356424, Seattle, WA 98195, USA
    Gastrointest Endosc Clin N Am 17:341-60, vi-vii. 2007
    ..Appropriate management includes supportive therapy and selective use of neostigmine and colonoscopy for decompression. Early recognition and management are critical in minimizing complications.
  97. ncbi Acetylcholinesterase inhibitors neostigmine and physostigmine inhibit induction of alpha-amylase activity during seed germination in barley, Hordeum vulgare var. Jyoti
    Veena Beri
    Department of Botany, University of Delhi, Delhi, 110007, India
    Life Sci 80:2386-8. 2007
    ..Jyoti were germinated in the presence of ACh, its breakdown products - choline and acetate, and two antiAChE - neostigmine and physostigmine (all 10(-5) M)...
  98. ncbi Acetylcholine causes rooting in leaf explants of in vitro raised tomato (Lycopersicon esculentum Miller) seedlings
    Kiran Bamel
    Department of Botany, University of Delhi, Delhi 110007, India
    Life Sci 80:2393-6. 2007
    ..ACh appears to have a natural role in tomato rhizogenesis because exogenous application of neostigmine, an inhibitor of ACh hydrolysis, could mimic the effect of ACh...
  99. pmc Cutaneous blood flow and sweat rate responses to exogenous administration of acetylcholine and methacholine
    Kenichi Kimura
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, TX 75231, USA
    J Appl Physiol 102:1856-61. 2007
    ..However, one of each of the ACh and MCh sites was also perfused with 10 microM neostigmine (an acetylcholinesterase inhibitor). Neostigmine at the ACh site induced a leftward shift (i.e...
  100. ncbi [Influence of neostigmine on the course of neuromuscular blockade with rocuronium or cisatracurium: a randomized, double-blind trial]
    J Barrio
    Servicio de Anestesiologia, Hospital Arnau de Vilanova, Valencia
    Rev Esp Anestesiol Reanim 54:399-404. 2007
    To compare the time-course of neuromuscular blockade with rocuronium or cisatracurium during intravenous anesthesia, in terms of both the time to spontaneous recovery or time to reversal after administration of neostigmine.
  101. ncbi Intraoperative anaphylaxis after intravenous atropine
    D Coelho
    Eur J Anaesthesiol 24:289-90. 2007

Research Grants75

  1. PYRIDOSTIGMINE FOR CONSTIPATION IN PATIENTS W/ AN AUTONOMIC NEUROPATHY
    Adil Bharucha; Fiscal Year: 2002
    ..We recently demonstrated that i.v. neostigmine increases colonic contractility and transit in healthy volunteers; neostigmine also increased colonic tone and ..
  2. PYRIDOSTIGMINE FOR CONSTIPATION IN PATIENTS W/ AN AUTONOMIC NEUROPATHY
    Adil Bharucha; Fiscal Year: 2001
    ..We recently demonstrated that i.v. neostigmine increases colonic contractility and transit in healthy volunteers; neostigmine also increased colonic tone and ..
  3. PYRIDOSTIGMINE FOR CONSTIPATION IN PATIENTS W/ AN AUTONOMIC NEUROPATHY
    Adil Bharucha; Fiscal Year: 1999
    ..We recently demonstrated that i.v. neostigmine increases colonic contractility and transit in healthy volunteers; neostigmine also increased colonic tone and ..
  4. PYRIDOSTIGMINE FOR CONSTIPATION IN PATIENTS W/ AN AUTONOMIC NEUROPATHY
    Adil Bharucha; Fiscal Year: 2000
    ..We recently demonstrated that i.v. neostigmine increases colonic contractility and transit in healthy volunteers; neostigmine also increased colonic tone and ..
  5. PARALYSIS--ITS ANTAGONISM DURING SURGERY AND ANESTHESIA
    Ronald Miller; Fiscal Year: 1990
    ..present granting period will be used to correlate the pharmacokinetics and pharmacodynamics of the antagonists neostigmine, pyridostigmine and edrophonium...
  6. SYSTEMATIC STUDY OF SELECTIVE SPINAL ANALGESIA IN HUMANS
    James Eisenach; Fiscal Year: 1992
    ..in sheep and humans, and clonidine-induced analgesia is inhibited by spinal atropine and enhanced by spinal neostigmine. We will test in humans whether spinal neostigmine enhances epidural clonidine analgesia by increasing ..
  7. SYSTEMATIC STUDY OF SELECTIVE SPINAL ANALGESIA IN HUMANS
    James Eisenach; Fiscal Year: 2006
    ..Since 1992, we have introduced clonidine, neostigmine, and adenosine into clinical trails and probed their mechanisms of action and efficacy in animals, volunteers ..
  8. SYSTEMATIC STUDY OF SELECTIVE SPINAL ANALGESIA IN HUMANS
    James Eisenach; Fiscal Year: 2003
    ..Since 1992, we have introduced clonidine, neostigmine, and adenosine into clinical trails and probed their mechanisms of action and efficacy in animals, volunteers ..
  9. HORMONAL INTEGRATION OF EXOCRINE AND ENDOCRINE ORGANS
    GABRIEL MAKHLOUF; Fiscal Year: 1980
    ..A second area of research involved studies of the origin of circulating VIP in the dog. Oxytocin and neostigmine were found to be potent releasers of VIP from the gut...
  10. BEHAVIORAL MECHANISMS IN CARDIOVASCULAR DISEASES
    Redford Williams; Fiscal Year: 1990
    ..isoproterenol infusions will be examined following placebo, vagal blockade (atropine), and vagal enhancement (neostigmine) pharmacological pretreatments...
  11. BEHAVIORAL MECHANISMS IN CARDIOVASCULAR DISEASES
    Redford Williams; Fiscal Year: 1992
    ..isoproterenol infusions will be examined following placebo, vagal blockade (atropine), and vagal enhancement (neostigmine) pharmacological pretreatments...
  12. HOSTILITY & CORONARY RISK: ROLE OF WEAK VAGAL FUNCTION
    Redford Williams; Fiscal Year: 1991
    ..measures and effects of isoproterenol infusion on EKG T-wave and ST response after pretreatment with saline, neostigmine, and atropine...
  13. PARALYSIS--ITS ANTAGONISM DURING SURGERY & ANESTHESIA
    Ronald Miller; Fiscal Year: 1980
    ..may alter the pharmacokinetics and pharmacodynamics of pancuronium and d-turbocurarine and their antagonists, neostigmine and pyridostigmine...
  14. SEX DIFFERENCES IN CHOLINERGIC MEDIATED ANALGESIA
    JOSEPH TOBIN; Fiscal Year: 1999
    ..We note in preliminary experiments a 2-fold increase in potency of intrathecal neostigmine in women volunteers and patients compared to men...
  15. SEX DIFFERENCES IN CHOLINERGIC MEDIATED ANALGESIA
    JOSEPH TOBIN; Fiscal Year: 2000
    ..We note in preliminary experiments a 2-fold increase in potency of intrathecal neostigmine in women volunteers and patients compared to men...
  16. Sex differences and estrogen dependency of spinal cord analgesia
    JOSEPH TOBIN; Fiscal Year: 2002
    ..We note in preliminary experiments a 2- fold increase in potency of intrathecal neostigmine in women volunteers and patients compared to men...
  17. DEVELOPMENT OF COMPLEX RETINAL FIELDS
    NORBERTO GRZYWACZ; Fiscal Year: 2000
    ..In particular, this model predicts the effects of neostigmine, a cholinesterase inhibitor, Cs+ and TEA, two K+-currents blockers, and Co2+, a synaptic blocker...
  18. DEVELOPMENT OF COMPLEX RETINAL FIELDS
    NORBERTO GRZYWACZ; Fiscal Year: 2001
    ..In particular, this model predicts the effects of neostigmine, a cholinesterase inhibitor, Cs+ and TEA, two K+-currents blockers, and Co2+, a synaptic blocker...
  19. DEVELOPMENT OF COMPLEX RETINAL FIELDS
    NORBERTO GRZYWACZ; Fiscal Year: 1999
    ..In particular, this model predicts the effects of neostigmine, a cholinesterase inhibitor, Cs+ and TEA, two K+-currents blockers, and Co2+, a synaptic blocker...
  20. DEVELOPMENT OF COMPLEX RETINAL FIELDS
    NORBERTO GRZYWACZ; Fiscal Year: 2001
    ..In particular, this model predicts the effects of neostigmine, a cholinesterase inhibitor, Cs+ and TEA, two K+-currents blockers, and Co2+, a synaptic blocker...
  21. Epidemiology and Mechanisms of Fecal Incontinence
    Adil Bharucha; Fiscal Year: 2005
    ..abstract_text> ..
  22. ANORECTAL MANIFESTATIONS OF FEMALE PELVIC FLOOR DISORDER
    Adil Bharucha; Fiscal Year: 2002
    ..abstract_text> ..
  23. Pathophysiology of Anorectal Disorders
    Adil Bharucha; Fiscal Year: 2009
    ..This proposal will enhance our understanding of the mechanisms and assess novel approaches to manage FI. ..
  24. ANORECTAL MANIFESTATIONS OF FEMALE PELVIC FLOOR DISORDER
    Adil Bharucha; Fiscal Year: 2000
    ..abstract_text> ..
  25. Epidemiology and Mechanisms of Fecal Incontinence
    Adil Bharucha; Fiscal Year: 2002
    ..abstract_text> ..
  26. Pathophysiology of Anorectal Disorders
    Adil Bharucha; Fiscal Year: 2008
    ..This proposal will enhance our understanding of the mechanisms and assess novel approaches to manage FI. ..
  27. Epidemiology and Mechanisms of Fecal Incontinence
    Adil Bharucha; Fiscal Year: 2003
    ..abstract_text> ..
  28. Pathophysiology of Anorectal Disorders
    Adil E Bharucha; Fiscal Year: 2010
    ..This proposal will enhance our understanding of the mechanisms and assess novel approaches to manage FI. ..
  29. ANORECTAL MANIFESTATIONS OF FEMALE PELVIC FLOOR DISORDER
    Adil Bharucha; Fiscal Year: 2001
    ..abstract_text> ..
  30. Epidemiology and Mechanisms of Fecal Incontinence
    Adil Bharucha; Fiscal Year: 2001
    ..abstract_text> ..
  31. Epidemiology and Mechanisms of Fecal Incontinence
    Adil Bharucha; Fiscal Year: 2004
    ..abstract_text> ..
  32. Viral Encephalitis, Chemokines and Sleep
    LARRY D contact SANFORD; Fiscal Year: 2010
    ..Such understanding may provide insight that could lead to improved therapies and improved prognosis for infectious diseases. ..
  33. CHOLINERGIC PHENOTYPE IN MURINE MODELS OF SLEEP
    Ralph Lydic; Fiscal Year: 2004
    ..Aim 1 will test the hypothesis that microinjecting neostigmine into the pontine reticular formation of B6 mouse causes a REM sleep-like state and changes in breathing that ..
  34. NEUROCHEMICAL INVOLVEMENT OF METHAMPHETAMINE SEEKING IN MICE
    GREGORY MARK; Fiscal Year: 2008
    ..These studies will address the issue of "stressor responsivity" and the findings will be directly relevant to work being done in the clinical and the behavioral genetic components of the center. ..
  35. CHOLINERGIC MECHANISMS OF BREATHING DURING SLEEP
    Ralph Lydic; Fiscal Year: 2006
    ..Aim 4 will use pontine and systemic drug administration to test the hypothesis that pontine cholinergic mechanisms modulate the ability of adenosine AI receptors to alter arousal and breathing. [unreadable] [unreadable]..
  36. General anesthetics and cerebral cortical sensory integration
    ANTHONY HUDETZ; Fiscal Year: 2009
    ..It should help develop novel methods for monitoring the state of consciousness based on established neurobiological mechanisms and of new anesthetic agents with more specific hypnotic effects. ..
  37. Limbic Modulation of Arousal and Alerting
    LARRY SANFORD; Fiscal Year: 2003
    ..This work also may be especially relevant to posttraumatic stress disorder (PTSD), which is typically characterized by a prominent sleep disturbance in the aftermath of exposure to a psychologically traumatic stressor. ..
  38. Anesthetics & cerebral cortical sensory integration
    ANTHONY HUDETZ; Fiscal Year: 2006
    ..abstract_text> ..
  39. CHOLINERGIC PHENOTYPE IN MURINE MODELS OF SLEEP
    Ralph Lydic; Fiscal Year: 2003
    ..Aim 1 will test the hypothesis that microinjecting neostigmine into the pontine reticular formation of B6 mouse causes a REM sleep-like state and changes in breathing that ..
  40. Anesthetics & cerebral cortical sensory integration
    ANTHONY HUDETZ; Fiscal Year: 2003
    ..abstract_text> ..
  41. OPIOID INDUCED REM SLEEP INHIBITION
    Ralph Lydic; Fiscal Year: 2004
    ..The potential health relatedness of these basic studies derives from the unwanted side effects of opioids on sleep and breathing. ..
  42. New PET Radiotracers-Monoamine Transporters
    Michael Kilbourn; Fiscal Year: 2003
    ....
  43. CHOLINERGIC MECHANISMS OF BREATHING DURING SLEEP
    Ralph Lydic; Fiscal Year: 2000
    ..A better understanding of these molecules will advance sleep and respiratory neurobiology and contribute to rational drug development. ..
  44. VOLATILE ANESTHETICS AND CEREBRAL BLOOD FLOW REGULATION
    ANTHONY HUDETZ; Fiscal Year: 1999
    ..They will determine if regional and agent-specific differences in microvascular vasodilation in response to volatile anesthetics are due to the effects of these agents on the GABA and NO neuronal systems. ..
  45. CHOLINERGIC MECHANISMS OF BREATHING DURING SLEEP
    Ralph Lydic; Fiscal Year: 1999
    ..Together, the 5 specific aims will provide information essential for rational drug development and for other important adjuncts to the clinical management of state-dependent respiratory depression. ..
  46. NEUROBIOLOGICAL EFFECTS OF ALTERED MOTOR CONTROL IN REM
    LARRY SANFORD; Fiscal Year: 2001
    ..These studies may lead to a better understanding of disorders of REM, such as REM behavior disorder, which, like REM-A, is characterized by overt behavior during sleep. ..
  47. CHOLINERGIC MECHANISMS OF BREATHING DURING SLEEP
    Ralph Lydic; Fiscal Year: 2001
    ..A better understanding of these molecules will advance sleep and respiratory neurobiology and contribute to rational drug development. ..
  48. NUCLEUS ACCUMBENS INVOLVEMENT IN COCAINE REINFORCEMENT
    GREGORY MARK; Fiscal Year: 2002
    ..It is hoped that these results will further our understanding of the involvement of cholinergic mechanisms in drug-seeking and potentially to the development of clinically efficacious treatments for drug craving and relapse. ..
  49. OPIOID INDUCED REM SLEEP INHIBITION
    Ralph Lydic; Fiscal Year: 2001
    ..The potential health relatedness of these basic studies derives from the unwanted side effects of opioids on sleep and breathing. ..
  50. Limbic Modulation of Arousal and Alerting
    LARRY SANFORD; Fiscal Year: 2001
    ..This work also may be especially relevant to posttraumatic stress disorder (PTSD), which is typically characterized by a prominent sleep disturbance in the aftermath of exposure to a psychologically traumatic stressor. ..
  51. New PET Radiotracers-Monoamine Transporters
    Michael Kilbourn; Fiscal Year: 2001
    ....
  52. New PET Radiotracers-Monoamine Transporters
    Michael Kilbourn; Fiscal Year: 2002
    ....
  53. Central Cholinergic Involvement in Cocaine Addiction
    GREGORY MARK; Fiscal Year: 2002
    ....
  54. MOTOR LEARNING IN CFS--NEURAL DYSFUNCTION IMPLICATION
    Richard Servatius; Fiscal Year: 2000
    ..We will then be in a position to relate learning abnormalities to brain pathology as measured in MRI scans and characterized by neuropsychological deficits. ..
  55. CHOLINERGIC PHENOTYPE IN MURINE MODELS OF SLEEP
    Ralph Lydic; Fiscal Year: 2005
    ..Aim 1 will test the hypothesis that microinjecting neostigmine into the pontine reticular formation of B6 mouse causes a REM sleep-like state and changes in breathing that ..
  56. CHOLINERGIC PHENOTYPE IN MURINE MODELS OF SLEEP
    Ralph Lydic; Fiscal Year: 2002
    ..Aim 4 will test the hypothesis that acetylcholine release in frontal association cortex is modulated by muscarinic cholinergic autoreceptors. Aim 4 will further determine the subtype of cortical muscarinic autoreceptor. ..
  57. Viral Encephalitis, Chemokines and Sleep
    LARRY SANFORD; Fiscal Year: 2009
    ..Such understanding may provide insight that could lead to improved therapies and improved prognosis for infectious diseases. ..
  58. OPIOID INDUCED REM SLEEP INHIBITION
    Ralph Lydic; Fiscal Year: 2002
    ..The potential health relatedness of these basic studies derives from the unwanted side effects of opioids on sleep and breathing. ..
  59. PHENOTYPICAL EXPRESSION OF ANXIETY AND SLEEP
    LARRY SANFORD; Fiscal Year: 2007
    ....
  60. PHENOTYPICAL EXPRESSION OF ANXIETY AND SLEEP
    LARRY SANFORD; Fiscal Year: 2006
    ....
  61. VOLATILE ANESTHETICS AND CEREBRAL BLOOD FLOW REGULATION
    ANTHONY HUDETZ; Fiscal Year: 2000
    ..They will determine if regional and agent-specific differences in microvascular vasodilation in response to volatile anesthetics are due to the effects of these agents on the GABA and NO neuronal systems. ..
  62. OPIOID INDUCED REM SLEEP INHIBITION
    Ralph Lydic; Fiscal Year: 2000
    ..These aims are conceptually unified, and related to the long-term goal, by their ability to specify brain stem cholinergic neurons and mechanisms causally contributing to opioid-induced inhibition of REM sleep. ..
  63. Central Cholinergic Involvement in Cocaine Addiction
    GREGORY MARK; Fiscal Year: 2005
    ....
  64. Anesthetics & cerebral cortical sensory integration
    ANTHONY HUDETZ; Fiscal Year: 2005
    ..abstract_text> ..
  65. PHENOTYPICAL EXPRESSION OF ANXIETY AND SLEEP
    LARRY SANFORD; Fiscal Year: 2001
    ..The investigators findings may be especially relevant to posttraumatic stress disorder (PTSD), which is typically characterized by a prominent sleep disturbance in the aftermath of exposure to a psychologically traumatic stressor. ..
  66. Anesthetics & cerebral cortical sensory integration
    ANTHONY HUDETZ; Fiscal Year: 2004
    ..abstract_text> ..