phosphorylcholine

Summary

Summary: Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.

Top Publications

  1. ncbi Visceral leishmaniasis: current status of control, diagnosis, and treatment, and a proposed research and development agenda
    Philippe J Guerin
    Norwegian Institute of Public Health, Norway
    Lancet Infect Dis 2:494-501. 2002
  2. ncbi Passive immunization with monoclonal IgM antibodies against phosphorylcholine reduces accelerated vein graft atherosclerosis in apolipoprotein E-null mice
    Jose R Faria-Neto
    Atherosclerosis Research Center, Division of Cardiology, Department of Medicine and Burns and Allen Research Institute, Cedars Sinai Medical Center and David Geffen School of Medicine at UCLA, Los Angeles, CA 90048, USA
    Atherosclerosis 189:83-90. 2006
  3. ncbi Oral miltefosine for Indian visceral leishmaniasis
    Shyam Sundar
    Institutes of Medical Sciences, Banaras Hindu University, Varanasi, India
    N Engl J Med 347:1739-46. 2002
  4. doi Miltefosine as an effective choice in the treatment of post-kala-azar dermal leishmaniasis
    V Ramesh
    Department of Dermatology, Safdarjung Hospital Institute of Pathology ICMR, Safdarjung Hospital Campus, New Delhi 110029, India
    Br J Dermatol 165:411-4. 2011
  5. pmc Miltefosine induces apoptosis-like death in Leishmania donovani promastigotes
    Caroline Paris
    UMR 8076 CNRS, Chimiothérapie Antiparasitaire, France
    Antimicrob Agents Chemother 48:852-9. 2004
  6. pmc Phosphorylcholine decreases early inflammation and promotes the establishment of stable biofilm communities of nontypeable Haemophilus influenzae strain 86-028NP in a chinchilla model of otitis media
    Wenzhou Hong
    Department of Microbiology and Immunology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Infect Immun 75:958-65. 2007
  7. ncbi Perifosine: update on a novel Akt inhibitor
    Joell J Gills
    Medical Oncology Branch, National Cancer Institute, NNMC Building 8, Room 5101, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA
    Curr Oncol Rep 11:102-10. 2009
  8. pmc Miltefosine affects lipid metabolism in Leishmania donovani promastigotes
    M Rakotomanga
    Chimiothérapie Antiparasitaire, UMR 8076 CNRS, Faculte de Pharmacie, Universite Paris Sud XI, F 92290 Chatenay Malabry, France
    Antimicrob Agents Chemother 51:1425-30. 2007
  9. ncbi Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor
    D R Cundell
    Laboratory of Molecular Infectious Diseases, Rockefeller University, New York, New York 10021 6399, USA
    Nature 377:435-8. 1995
  10. doi Comparison of short-course multidrug treatment with standard therapy for visceral leishmaniasis in India: an open-label, non-inferiority, randomised controlled trial
    Shyam Sundar
    Kala azar Medical Research Center, Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
    Lancet 377:477-86. 2011

Research Grants

  1. BACTERIAL PHOSPHORYLCHOLINE AND PATHOGENESIS
    Jeffrey Weiser; Fiscal Year: 2003
  2. Deregulated lipid metabolism in stroke
    RAO M ADIBHATLA; Fiscal Year: 2010
  3. Development of Chemical Receptors for Proteins
    Sanku Mallik; Fiscal Year: 2005
  4. CDP-choline: Mechanisms in Cerebral Ischemia
    RAO ADIBHATLA; Fiscal Year: 2006
  5. Bacterial biofilms in otitis media
    WILLIAM SWORDS; Fiscal Year: 2009
  6. Bacterial biofilms in otitis media
    WILLIAM SWORDS; Fiscal Year: 2007
  7. Structure-Function Relationships of C-Reactive Protein
    Alok Agrawal; Fiscal Year: 2006
  8. BIOACTIVITIES OF PNEUMOCOCCAL CELL WALL IN MENINGITIS
    Elaine I Tuomanen; Fiscal Year: 2011
  9. GENETICS & VIRULENCE OF PNEUMOCOCCAL CAPSULAR TYPES
    Janet Yother; Fiscal Year: 1993
  10. Genetic Control of Phospholipid Biosynthesis and Muscular Dystrophy
    Gregory A Cox; Fiscal Year: 2010

Detail Information

Publications321 found, 100 shown here

  1. ncbi Visceral leishmaniasis: current status of control, diagnosis, and treatment, and a proposed research and development agenda
    Philippe J Guerin
    Norwegian Institute of Public Health, Norway
    Lancet Infect Dis 2:494-501. 2002
    ..This article reviews the current situation and perspectives for diagnosis, treatment, and control of visceral leishmaniasis, and lists some priorities for research and development...
  2. ncbi Passive immunization with monoclonal IgM antibodies against phosphorylcholine reduces accelerated vein graft atherosclerosis in apolipoprotein E-null mice
    Jose R Faria-Neto
    Atherosclerosis Research Center, Division of Cardiology, Department of Medicine and Burns and Allen Research Institute, Cedars Sinai Medical Center and David Geffen School of Medicine at UCLA, Los Angeles, CA 90048, USA
    Atherosclerosis 189:83-90. 2006
    b>Phosphorylcholine (PC) headgroup is one of the neoantigens exposed by LDL oxidation that can elicit an immune response...
  3. ncbi Oral miltefosine for Indian visceral leishmaniasis
    Shyam Sundar
    Institutes of Medical Sciences, Banaras Hindu University, Varanasi, India
    N Engl J Med 347:1739-46. 2002
    ..We performed a clinical trial in India comparing miltefosine with the most effective standard treatment, amphotericin B...
  4. doi Miltefosine as an effective choice in the treatment of post-kala-azar dermal leishmaniasis
    V Ramesh
    Department of Dermatology, Safdarjung Hospital Institute of Pathology ICMR, Safdarjung Hospital Campus, New Delhi 110029, India
    Br J Dermatol 165:411-4. 2011
    ..Unacceptable treatment regimens and increasing drug resistance blight control programmes. The success of oral miltefosine in VL prompted a clinical, histopathological and parasitological study of this drug in PKDL...
  5. pmc Miltefosine induces apoptosis-like death in Leishmania donovani promastigotes
    Caroline Paris
    UMR 8076 CNRS, Chimiothérapie Antiparasitaire, France
    Antimicrob Agents Chemother 48:852-9. 2004
    ..Identification of the death-signaling pathways activated in HePC-sensitive parasites appears to be essential for a better understanding of the molecular mechanisms of action and resistance in these parasites...
  6. pmc Phosphorylcholine decreases early inflammation and promotes the establishment of stable biofilm communities of nontypeable Haemophilus influenzae strain 86-028NP in a chinchilla model of otitis media
    Wenzhou Hong
    Department of Microbiology and Immunology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Infect Immun 75:958-65. 2007
    ..b>Phosphorylcholine (PCho) is added to some LOS forms in a phase-variable manner, and these PCho(+) variants predominate in vivo...
  7. ncbi Perifosine: update on a novel Akt inhibitor
    Joell J Gills
    Medical Oncology Branch, National Cancer Institute, NNMC Building 8, Room 5101, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA
    Curr Oncol Rep 11:102-10. 2009
    ..In this article, we review the clinical history of perifosine and discuss its many biologic activities...
  8. pmc Miltefosine affects lipid metabolism in Leishmania donovani promastigotes
    M Rakotomanga
    Chimiothérapie Antiparasitaire, UMR 8076 CNRS, Faculte de Pharmacie, Universite Paris Sud XI, F 92290 Chatenay Malabry, France
    Antimicrob Agents Chemother 51:1425-30. 2007
    ....
  9. ncbi Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor
    D R Cundell
    Laboratory of Molecular Infectious Diseases, Rockefeller University, New York, New York 10021 6399, USA
    Nature 377:435-8. 1995
    ..Only virulent pneumococci engage the PAF receptor. Attachment of the bacterial phosphorylcholine to the PAF receptor enhanced adherence, which was coupled to invasion of endothelial, epithelial and PAF-..
  10. doi Comparison of short-course multidrug treatment with standard therapy for visceral leishmaniasis in India: an open-label, non-inferiority, randomised controlled trial
    Shyam Sundar
    Kala azar Medical Research Center, Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
    Lancet 377:477-86. 2011
    ..Improved treatment approaches are needed for visceral leishmaniasis. We assessed the efficacy and safety of three potential short-course combination treatments compared with the standard monotherapy in India...
  11. doi Low levels of IgM antibodies to phosphorylcholine predict cardiovascular disease in 60-year old men: effects on uptake of oxidized LDL in macrophages as a potential mechanism
    Ulf de Faire
    Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Autoimmun 34:73-9. 2010
    We here determine the role of IgM antibodies against phosphorylcholine (anti-PC) in prediction of cardiovascular disease (CVD) and on macrophage uptake of Oxidized LDL (OxLDL).
  12. pmc Phosphorylcholine on the lipopolysaccharide of Haemophilus influenzae contributes to persistence in the respiratory tract and sensitivity to serum killing mediated by C-reactive protein
    J N Weiser
    Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Exp Med 187:631-40. 1998
    Haemophilus influenzae undergoes phase variation in expression of the phosphorylcholine (ChoP) epitope, a structure present on several invasive pathogens residing in the human respiratory tract...
  13. pmc Synergistic proapoptotic activity of recombinant TRAIL plus the Akt inhibitor Perifosine in acute myelogenous leukemia cells
    Pier Luigi Tazzari
    Servizio di Immunoematologia e Trasfusionale, Policlinico S Orsola Malpighi, Universita di Bologna, Italy
    Cancer Res 68:9394-403. 2008
    ..In contrast, CD34(+) cells from healthy donors were resistant to perifosine and TRAIL treatment. Our findings suggest that the combination of perifosine and TRAIL might offer a novel therapeutic strategy for AML...
  14. ncbi Characterisation of Leishmania donovani promastigotes resistant to hexadecylphosphocholine (miltefosine)
    Karin Seifert
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Int J Antimicrob Agents 22:380-7. 2003
    ..Resistance was stable up to 12 weeks in drug-free culture medium. No amplification of specific genes, including the multidrug resistance P-glycoprotein gene, could be detected in the resistant parasites...
  15. pmc In vitro susceptibility of field isolates of Leishmania donovani to Miltefosine and amphotericin B: correlation with sodium antimony gluconate susceptibility and implications for treatment in areas of endemicity
    Dhiraj Kumar
    Institute of Pathology, Safdarjung Hospital Campus, New Delhi, India
    Antimicrob Agents Chemother 53:835-8. 2009
    ..The results of gene expression analysis of LdMT and LdRos3 were suggestive of alternate mechanisms of Miltefosine susceptibility in the isolates...
  16. doi A Rho kinase/myocardin-related transcription factor-A-dependent mechanism underlies the sphingosylphosphorylcholine-induced differentiation of mesenchymal stem cells into contractile smooth muscle cells
    Eun Su Jeon
    Department of Physiology, Pusan National University College of Medicine, Busan 602 739, Republic of Korea
    Circ Res 103:635-42. 2008
    ..These results suggest that SPC induced differentiation of hADSCs into contractile SMCs through a mechanism involving RhoA/Rho kinase-dependent nuclear translocation of MRTF-A...
  17. pmc Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy
    Lei Fu
    Department of Hematology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Cancer Res 69:8967-76. 2009
    ....
  18. doi Novel phosphorylcholine-containing protein of Pseudomonas aeruginosa chronic infection isolates interacts with airway epithelial cells
    Mariette Barbier
    Institut Universitari d Investigacions en Ciències de la Salut, Palma de Mallorca, Spain
    J Infect Dis 197:465-73. 2008
    Pseudomonas aeruginosa undergoes phase variation in the expression of the phosphorylcholine (ChoP) epitope, a structure crucial for the virulence of several respiratory pathogens...
  19. ncbi Phosphocholine of pneumococcal teichoic acids: role in bacterial physiology and pneumococcal infection
    W Fischer
    Institut fur Biochemie, Med Fak, Universitat Erlangen Nurnberg, Erlangen, Germany
    Res Microbiol 151:421-7. 2000
    ..The genes encoding the enzymes for PCho incorporation are described. Two strains that acquired the ability to grow in the absence of choline are discussed...
  20. ncbi Oral miltefosine treatment in children with mild to moderate Indian visceral leishmaniasis
    Shyam Sundar
    Institutes of Medical Sciences, Banaras Hindu University, 6 SK Gupta Nagar, Varanasi 221005, India
    Pediatr Infect Dis J 22:434-8. 2003
    ..Because approximately one-half of the visceral leishmaniasis patients worldwide are children, we performed a Phase I/II dose ranging study in the pediatric population in India...
  21. ncbi Intranasal immunization with phosphorylcholine induces antigen specific mucosal and systemic immune responses in mice
    Norimitsu Tanaka
    Department of Otolaryngology, Head and Neck Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Vaccine 25:2680-7. 2007
    b>Phosphorylcholine (PC) is a structural component of a wide variety of pathogens including Streptococcus pneumoniae and Haemophilus influenzae, and anti-PC immune responses are known to protect mice against invasive bacterial diseases...
  22. doi Akt down-modulation induces apoptosis of human prostate cancer cells and synergizes with EGFR tyrosine kinase inhibitors
    Claudio Festuccia
    Departments of Experimental Medicine, University of L Aquila, L Aquila, Italy
    Prostate 68:965-74. 2008
    ..PTEN is a well-characterized tumor suppressor that negatively regulates cell growth and survival through the modulation of PI3K/Akt pathway...
  23. ncbi B-1 cells: the lineage question revisited
    L A Herzenberg
    Department of Genetics, Stanford University School of Medicine, CA 94305, USA
    Immunol Rev 175:9-22. 2000
    ....
  24. ncbi Development of miltefosine as an oral treatment for leishmaniasis
    H Sindermann
    Zentaris GmbH, Weismuellerstrasse 50, 60314 Frankfurt, Germany
    Trans R Soc Trop Med Hyg 100:S17-20. 2006
    ..It is therefore contraindicated for use during pregnancy, and contraception is required beyond the end of treatment in women of child-bearing age...
  25. pmc Pharmacokinetics of miltefosine in Old World cutaneous leishmaniasis patients
    Thomas P C Dorlo
    Department of Pharmacy and Pharmacology, Slotervaart Hospital The Netherlands Cancer Institute, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands
    Antimicrob Agents Chemother 52:2855-60. 2008
    ....
  26. pmc Phosphorylcholine expression by nontypeable Haemophilus influenzae correlates with maturation of biofilm communities in vitro and in vivo
    Wenzhou Hong
    Department of Microbiology and Immunology, Wake Forest University Health Sciences, 5101A Gray Building, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Bacteriol 189:8300-7. 2007
    ..NTHI variants within biofilms have on their surfaces lipooligosaccharides containing sialic acid (NeuAc) and phosphorylcholine (PCho)...
  27. pmc Randomized controlled clinical trial to access efficacy and safety of miltefosine in the treatment of cutaneous leishmaniasis Caused by Leishmania (Viannia) guyanensis in Manaus, Brazil
    Anette Chrusciak-Talhari
    Fundação de Medicina Tropical do Amazonas and Universidade Estadual do Amazonas, Manaus, AM, Brasil
    Am J Trop Med Hyg 84:255-60. 2011
    ..05) for miltefosine and antimonial, respectively. There were no differences in cure rates between age groups within the same treatment arms. Miltefosine was safe and relatively well tolerated and cure rate was higher than antimony...
  28. doi Low levels of antibodies against phosphorylcholine predict development of stroke in a population-based study from northern Sweden
    Roland Fiskesund
    Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
    Stroke 41:607-12. 2010
    Natural immunoglobulin M antibodies specific for phosphorylcholine (anti-PC) have been implicated in atherosclerosis...
  29. pmc The phosphorylcholine epitope undergoes phase variation on a 43-kilodalton protein in Pseudomonas aeruginosa and on pili of Neisseria meningitidis and Neisseria gonorrhoeae
    J N Weiser
    Departments of Pediatrics and Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Infect Immun 66:4263-7. 1998
    b>Phosphorylcholine (ChoP) is a component of the teichoic acids of Streptococcus pneumoniae and has been recently identified on the lipopolysaccharide of Haemophilus influenzae, also a major pathogen of the human respiratory tract...
  30. ncbi Detection of increased choline compounds with proton nuclear magnetic resonance spectroscopy subsequent to malignant transformation of human prostatic epithelial cells
    E Ackerstaff
    Magnetic Resonance Oncology Section, Division of Magnetic Resonance Research, Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 61:3599-603. 2001
    ..These data strongly support the use of proton magnetic resonance spectroscopic imaging to detect the presence of prostate cancer for diagnosis, to detect response subsequent to androgen ablation therapy, and to detect recurrence...
  31. doi Visceral leishmaniasis: elimination with existing interventions
    Greg Matlashewski
    Special Programme for Research and Training in Tropical Diseases, WHO, Geneva, Switzerland
    Lancet Infect Dis 11:322-5. 2011
    ....
  32. ncbi Inactivation of the miltefosine transporter, LdMT, causes miltefosine resistance that is conferred to the amastigote stage of Leishmania donovani and persists in vivo
    Karin Seifert
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Int J Antimicrob Agents 30:229-35. 2007
    ..90% inhibition in wild-type infections). No cross-resistance to other antileishmanial drugs was observed in M-mutR amastigotes...
  33. pmc Lipooligosaccharides containing phosphorylcholine delay pulmonary clearance of nontypeable Haemophilus influenzae
    Bing Pang
    Department of Microbiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Infect Immun 76:2037-43. 2008
    ..Persistent NTHi populations express a discrete subset of LOS glycoforms, including those containing phosphorylcholine (PCho)...
  34. doi Low level natural antibodies against phosphorylcholine: a novel risk marker and potential mechanism in atherosclerosis and cardiovascular disease
    Johan Frostegard
    Department of Medicine, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden
    Clin Immunol 134:47-54. 2010
    ..A common denominator is phosphorylcholine (PC), a hapten-like epitope which is exposed on OxLDL and some microorganisms...
  35. pmc Possible mechanism of miltefosine-mediated death of Leishmania donovani
    Navin K Verma
    Department of Biotechnology, National Institute of Pharmaceutical Education and Research, Punjab, India
    Antimicrob Agents Chemother 48:3010-5. 2004
    ..Understanding of miltefosine-mediated death will facilitate the design of new therapeutic strategies against Leishmania parasites...
  36. ncbi Phase 4 trial of miltefosine for the treatment of Indian visceral leishmaniasis
    Sujit Kumar Bhattacharya
    Rajendra Memorial Research Institute of Medical Sciences, Agam Kuan, India
    J Infect Dis 196:591-8. 2007
    ..Hospital-based studies have shown that oral miltefosine is a highly effective treatment for VL both in adults and in children...
  37. pmc Alteration of fatty acid and sterol metabolism in miltefosine-resistant Leishmania donovani promastigotes and consequences for drug-membrane interactions
    M Rakotomanga
    Chimiothérapie Antiparasitaire, UMR 8076 CNRS, Faculte de Pharmacie, Universite Paris XI, F 92290, Chatenay Malabry, France
    Antimicrob Agents Chemother 49:2677-86. 2005
    ..In conclusion, HePC resistance affects three lipid biochemical pathways: fatty acid elongation, the desaturase system responsible for fatty acid alkyl chain unsaturation, and the C-24-alkylation of sterols...
  38. ncbi Phase II study of perifosine in previously untreated patients with metastatic melanoma
    D Scott Ernst
    London Regional Cancer Centre, 790 Commissioners Rd East, London, ON N6A 4L6, UK
    Invest New Drugs 23:569-75. 2005
    ..To assess the response rate and toxicity of the alkylphosphocholine analogue, perifosine, in patients with metastatic or recurrent malignant melanoma...
  39. ncbi Sensitivities of Leishmania species to hexadecylphosphocholine (miltefosine), ET-18-OCH(3) (edelfosine) and amphotericin B
    Patricia Escobar
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Acta Trop 81:151-7. 2002
    ..5-37.1 microM against amastigotes. Amphotericin B deoxycholate was used as the standard drug and gave submicromolar ED(50) values in all assays; L. mexicana was the least sensitive species to this drug...
  40. ncbi Mechanisms of experimental resistance of Leishmania to miltefosine: Implications for clinical use
    F Javier Pérez-Victoria
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Spanish Research Council C S I C, Technological Park of Health Sciences, Avda del Conocimiento s n, 18100 Armilla, Granada, Spain
    Drug Resist Updat 9:26-39. 2006
    ....
  41. pmc Rheumatoid cachexia is associated with dyslipidemia and low levels of atheroprotective natural antibodies against phosphorylcholine but not with dietary fat in patients with rheumatoid arthritis: a cross-sectional study
    Ann Charlotte Elkan
    Department of Rheumatology, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Arthritis Res Ther 11:R37. 2009
    ..The aim of this study was to analyze the associations between diet, body composition, lipids and atheroprotective natural antibodies against phosphorylcholine (anti-PC) in patients with RA.
  42. ncbi Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts
    Consuelo Gajate
    Unidad de Investigacion, Hospital Universitario de Salamanca, Spain
    Blood 109:711-9. 2007
    ..These data uncover a novel lipid raft-mediated therapy in MM involving concentration of death receptors in membrane rafts, with Fas/CD95 playing a major role in ALP-mediated apoptosis...
  43. pmc Decoration of lipopolysaccharide with phosphorylcholine: a phase-variable characteristic of Haemophilus influenzae
    J N Weiser
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 19104 4318, USA
    Infect Immun 65:943-50. 1997
    ..Incorporated choline is in the form of phosphorylcholine (ChoP) based on the reactivity with the monoclonal antibody with specificity for this structure, TEPC-15...
  44. ncbi Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo
    Hiroyuki Momota
    Department of Cancer Biology and Genetics and Surgery Neurosurgery and Neurology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 65:7429-35. 2005
    ..01). These results indicate that perifosine is an effective drug in gliomas in which Akt and Ras-Erk 1/2 pathways are frequently activated, and may be a new candidate for glioma treatment in the clinic...
  45. doi Molecular simulation studies of protein interactions with zwitterionic phosphorylcholine self-assembled monolayers in the presence of water
    Yi He
    Department of Chemical Engineering, University of Washington, Seattle, WA 98195, USA
    Langmuir 24:10358-64. 2008
    Molecular simulations were performed to study the interactions between a protein (lysozyme, LYZ) and phosphorylcholine-terminated self-assembled monolayers (PC-SAMs) in the presence of explicit water molecules and ions...
  46. doi Identification of phospholipid species affected by miltefosine action in Leishmania donovani cultures using LC-ELSD, LC-ESI/MS, and multivariate data analysis
    L Imbert
    Groupe de Chimie Analytique de Paris Sud, EA4041, Faculte de Pharmacie, Univ Paris Sud, 5 Rue Jean Baptiste Clement, 92296 Chatenay Malabry Cedex, France
    Anal Bioanal Chem 402:1169-82. 2012
    ..Structural determination of the most relevant species has finally been performed using tandem mass spectrometry. A first hypothesis on the effect of miltefosine on lipid metabolic pathways is then proposed...
  47. pmc Induction of thyroid gene expression and radioiodine uptake in thyroid cancer cells by targeting major signaling pathways
    Peng Hou
    Division of Endocrinology and Metabolism, The Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 333, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 95:820-8. 2010
    ..Further studies are warranted to test this therapeutic potential in restoring radioiodine avidity of thyroid cancer cells for effective ablation treatment...
  48. doi Autoantibodies against apolipoprotein A-1 and phosphorylcholine for diagnosis of non-ST-segment elevation myocardial infarction
    P F Keller
    Division of Cardiology, Department of Internal Medicine, Geneva University Hospitals, Geneva, Switzerland
    J Intern Med 271:451-62. 2012
    To explore the diagnostic accuracies of anti-apolipoproteinA-1 (anti-ApoA-1) IgG and anti-phosphorylcholine (anti-PC) IgM alone, expressed as a ratio (anti-ApoA-1 IgG/anti-PC IgM), and combined with the Thrombolysis In Myocardial ..
  49. doi Perifosine induces protective autophagy and upregulation of ATG5 in human chronic myelogenous leukemia cells in vitro
    Yin Tong
    Institute of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
    Acta Pharmacol Sin 33:542-50. 2012
    ..In this study, the cytotoxic effects of perifosine on CML and acute myeloid leukemia (AML) cell lines were compared to elucidate the mechanisms underlying the differences...
  50. ncbi Relapse of visceral leishmaniasis after miltefosine treatment in a Nepalese patient
    Basu Dev Pandey
    Sukraraj Tropical and Infectious Diseases Hospital, Kathmandu, Nepal
    Am J Trop Med Hyg 80:580-2. 2009
    ..The patient was subsequently treated with 1 mg/kg of amphotericin B for a total of 14 days and recovered completely...
  51. ncbi Neisseria gonorrhoeae type IV pili undergo multisite, hierarchical modifications with phosphoethanolamine and phosphocholine requiring an enzyme structurally related to lipopolysaccharide phosphoethanolamine transferases
    Finn Erik Aas
    Centre for Molecular Biology and Neuroscience, Department of Molecular Biosciences, University of Oslo, 0316 Oslo, Norway
    J Biol Chem 281:27712-23. 2006
    ..Together, these findings have important implications for the structure and antigenicity of PilE...
  52. ncbi Physical properties and pharmacological activity in vitro and in vivo of optimised liposomes prepared from a new cancerostatic alkylphospholipid
    R Zeisig
    Phospholipids Department, Max Delbruck Centre for Molecular Medicine, R Rössle Str 10, 13122 Berlin Buch, Germany
    Biochim Biophys Acta 1414:238-48. 1998
    ..The beneficial therapeutic effect of these liposomes was accompanied by better tolerance and a significant inhibition of haemolysis compared to micellar OPP...
  53. ncbi Effect of biological therapy on levels of atheroprotective antibodies against phosphorylcholine and apolipoproteins in rheumatoid arthritis - a one year study
    Sofia Ajeganova
    Karolinska University Hospital Huddinge, Stockholm, Sweden
    Clin Exp Rheumatol 29:942-50. 2011
    ..B-cell targeting rituximab influences novel markers of atherosclerosis and inflammation, such as atheroprotective natural IgM antibodies against phosphorylcholine (anti-PC), oxidised low-density lipoprotein (oxLDL) and apolipoproteins.
  54. ncbi Characterisation of the phosphorylcholine-containing N-linked oligosaccharides in the excretory-secretory 62 kDa glycoprotein of Acanthocheilonema viteae
    S M Haslam
    Department of Biochemistry, Imperial College, London, UK
    Mol Biochem Parasitol 85:53-66. 1997
    ..product of the rodent filarial nematode Acanthocheilonema viteae is a 62 kDa glycoprotein (ES-62), which has phosphorylcholine, attached to the N-linked carbohydrates...
  55. pmc Identification and characterization of pptA: a gene involved in the phase-variable expression of phosphorylcholine on pili of Neisseria meningitidis
    Matthew J Warren
    Department of Microbiology and Parasitology, School of Molecular and Microbial Sciences, University of Queensland, Brisbane, Australia
    Infect Immun 71:6892-8. 2003
    ..Pili are modified posttranslationally by the addition of phosphorylcholine. However, no genes involved in either the biosynthesis or the transfer of phosphorylcholine in Neisseria ..
  56. pmc Perifosine as a potential novel anti-cancer agent inhibits EGFR/MET-AKT axis in malignant pleural mesothelioma
    Giulia Pinton
    Department of Pharmaceutical Sciences and Drug and Food Biotechnology Center, University of Piemonte Orientale A Avogadro, Novara, Italy
    PLoS ONE 7:e36856. 2012
    ....
  57. ncbi Alkylphospholipids inhibit capillary-like endothelial tube formation in vitro: antiangiogenic properties of a new class of antitumor agents
    Shuraila F Zerp
    Division of Cellular Biochemistry, Department of Pathology, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Plesmanlaan, CX Amsterdam, The Netherlands
    Anticancer Drugs 19:65-75. 2008
    ..Interference with the angiogenic process represents a novel mode of action of APLs and might significantly contribute to the antitumor effect of these compounds...
  58. ncbi Cure of antimony-unresponsive Indian post-kala-azar dermal leishmaniasis with oral miltefosine
    Shyam Sundar
    Kala azar Medical Research Center, Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, India
    Trans R Soc Trop Med Hyg 100:698-700. 2006
    ..Oral miltefosine appears to be an important alternative for the treatment of PKDL in India and confirmatory studies in controlled clinical trials are needed...
  59. ncbi Phase II study of daily oral perifosine in patients with advanced soft tissue sarcoma
    Howard H Bailey
    University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin 53792, USA
    Cancer 107:2462-7. 2006
    ....
  60. ncbi Piezoelectric immunosensor for bisphenol A based on signal enhancing step with 2-methacrolyloxyethyl phosphorylcholine polymeric nanoparticle
    Jong Won Park
    Institute for Environmental Management Technology, National Institute of Advanced Industrial Science and Technology AIST, 1 1Higashi, Tsukuba 305 8565, Japan
    Analyst 131:155-62. 2006
    ..Field emission-scanning electron microscopy (FE-SEM) showed that polymeric 2-methacrolyloxyethyl phosphorylcholine (MPC) nanoparticles coupled to antibodies remained monodisperse on the surface of the immunosensor and ..
  61. pmc Microbial modulation of host immunity with the small molecule phosphorylcholine
    Sarah E Clark
    Department of Microbiology, University of Pennsylvania, Philadelphia, PA, USA
    Infect Immun 81:392-401. 2013
    ..The small molecule phosphorylcholine, or choline phosphate (ChoP), is used for both of these purposes by a wide array of bacterial and parasitic ..
  62. pmc Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment
    David Gallego-Ortega
    Translational Oncology Unit, CSIC UAM La Paz, Instituto de Investigaciones Biomedicas, Madrid, Spain
    PLoS ONE 4:e7819. 2009
    ..Recently ChoKalpha has been implicated in the carcinogenic process, since it is over-expressed in a variety of human cancers. However, no evidence for a role of ChoKbeta in carcinogenesis has been reported...
  63. ncbi Phosphocholine and sphingosine-1-phosphate synergistically stimulate DNA synthesis by a MAP kinase-dependent mechanism
    Z Kiss
    The Hormel Institute, University of Minnesota, Austin 55912, USA
    FEBS Lett 412:197-200. 1997
    ....
  64. ncbi Anticancer alkylphospholipids: mechanisms of action, cellular sensitivity and resistance, and clinical prospects
    Wim J van Blitterswijk
    Division of Cellular Biochemistry, Department of Radiotherapy, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Curr Pharm Des 14:2061-74. 2008
    ..For example, ALPs increase the cancer cell sensitivity to radiotherapy in vitro and in vivo. We highlight the clinical potential of perifosine, an orally available APL...
  65. ncbi Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells
    V Papa
    Dipartimento di Scienze Anatomiche Umane e Fisiopatologia dell Apparato Locomotore, Universita di Bologna, Bologna, Italy
    Leukemia 22:147-60. 2008
    ..Our findings indicate that perifosine, either alone or in combination with existing drugs, might be a promising therapeutic agent for the treatment of those AML cases characterized by upregulation of the PI3K-Akt survival pathway...
  66. ncbi First case of typical Old World cutaneous leishmaniasis treated with miltefosine
    Marija Stojkovic
    Section of Clinical Tropical Medicine, Heidelberg University Hospital, Heidelberg, and General Practice, Dreisamstr 11, Freiburg, Germany
    Int J Dermatol 46:385-7. 2007
    ..Ten days after completion of treatment, the rolled edge had disappeared and the central ulcer had almost healed (Fig. 3). Figure 4 shows the lesion 5 months after completion of treatment...
  67. ncbi Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species
    Mohamed Rahmani
    Department of Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, USA
    Cancer Res 65:2422-32. 2005
    ..They also raise the possibility that combining these agents may represent a novel antileukemic strategy...
  68. ncbi Treatment of New World cutaneous leishmaniasis with miltefosine
    J Soto
    Consorcio de Investigaciones Bioclinicas, Calle 60 A 5 54 Suite 201, Bogota, Colombia
    Trans R Soc Trop Med Hyg 100:S34-40. 2006
    ..Miltefosine was well tolerated, and as effective as historic values of antimony for treatment of L. panamensis disease...
  69. doi Miltefosine treatment of Leishmania major infection: an observational study involving Dutch military personnel returning from northern Afghanistan
    P P A M van Thiel
    Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS and Center for Infection and Immunity, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Clin Infect Dis 50:80-3. 2010
    ..Thirty patients experienced cure after receipt of miltefosine, 3 after receipt of additional ilSb(v), and 1 after 28 daily intravenous injections of antimony. Temporary diminution of ejaculate volume was reported by 21 patients...
  70. ncbi Increased junctional diversity in fetal B cells results in a loss of protective anti-phosphorylcholine antibodies in adult mice
    C L Benedict
    Department of Microbiology, University of Alabama at Birmingham, 35294 3300, USA
    Immunity 10:607-17. 1999
    ..These results show that maintenance of lower Ig diversity in early life is essential for the acquisition of a complete functional adult repertoire...
  71. ncbi The sensitivity of clinical isolates of Leishmania from Peru and Nepal to miltefosine
    Vanessa Yardley
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Am J Trop Med Hyg 73:272-5. 2005
    ..If this model can be correlated to therapeutic outcome, it may have implications for the interpretation of clinical trials...
  72. doi Changes in choline metabolism as potential biomarkers of phospholipase C{gamma}1 inhibition in human prostate cancer cells
    Mounia Beloueche-Babari
    Cancer Research UK Clinical Magnetic Resonance Research Group, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom
    Mol Cancer Ther 8:1305-11. 2009
    ....
  73. pmc Increased prevalence of vulnerable atherosclerotic plaques and low levels of natural IgM antibodies against phosphorylcholine in patients with systemic lupus erythematosus
    Cristina Anania
    Department of Medicine, Karolinska University Hospital, Huddinge, 141 86 Stockholm, Sweden
    Arthritis Res Ther 12:R214. 2010
    ..We recently reported a negative association between natural IgM-antibodies against phosphorylcholine (anti-PC) in the general population, high anti-PC levels leading to decreased atherosclerosis development ..
  74. doi Miltefosine, a promising novel agent for schistosomiasis mansoni
    Maha M Eissa
    Department of Medical Parasitology, Faculty of Medicine, Alexandria University, Alexandria, Egypt
    Int J Parasitol 41:235-42. 2011
    ..In conclusion, we believe this is the first study highlighting miltefosine as a promising novel agent for schistosomiasis mansoni...
  75. doi Perifosine synergistically enhances TRAIL-induced myeloma cell apoptosis via up-regulation of death receptors
    Ebenezer David
    Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA
    Clin Cancer Res 14:5090-8. 2008
    ..The aim of this study is to investigate the efficacy of a novel Akt inhibitor, perifosine, in combination with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in human myeloma cells and primary patient samples...
  76. doi Transition from octahedral to tetrahedral geometry causes the activation or inhibition by Znf2+ of Pseudomonas aeruginosa phosphorylcholine phosphatase
    Lisandro H Otero
    Departamento de Biologia Molecular, Universidad Nacional de Rio Cuarto, 5800 Rio Cuarto, Cordoba, Argentina
    Biometals 23:307-14. 2010
    Pseudomonas aeruginosa phosphorylcholine phosphatase (PchP) catalyzes the hydrolysis of phosphorylcholine, which is produced by the action of hemolytic phospholipase C on phosphatidylcholine or sphyngomielin, to generate choline and ..
  77. doi Anti-acanthamoeba efficacy and toxicity of miltefosine in an organotypic skin equivalent
    Julia Walochnik
    Department of Medical Parasitology, Institute of Hygiene, Medical University of Vienna, 1095 Vienna, Austria
    J Antimicrob Chemother 64:539-45. 2009
    ..in vitro. The aim of the current study was to evaluate the suitability of miltefosine for the topical treatment of Acanthamoeba infections...
  78. pmc The acute-phase reactant C-reactive protein binds to phosphorylcholine-expressing Neisseria meningitidis and increases uptake by human phagocytes
    Rosalyn Casey
    Division of Microbial Sciences, Faculty of Health and Medical Sciences, University of Surrey, Stag Hill, Guildford, Surrey GU2 7XH, United Kingdom
    Infect Immun 76:1298-304. 2008
    ..has been shown to help protect the host from several bacterial pathogens, which it recognizes by binding to phosphorylcholine (PC) on their surfaces...
  79. doi Sphingosylphosphorylcholine inhibits melanin synthesis via pertussis toxin-sensitive MITF degradation
    Dong Seok Kim
    Department of Biochemistry, Chung Ang University College of Medicine, Seoul, Republic of Korea
    J Pharm Pharmacol 62:181-7. 2010
    ..In this study we aimed to examine sphingosylphosphorylcholine-mediated signalling pathways related to melanogenesis...
  80. ncbi Quantification of the response to miltefosine treatment for visceral leishmaniasis by QT-NASBA
    P J de Vries
    Academic Medical Center, Division of Infectious Diseases, Tropical Medicine and AIDS, Meibergdreef 9, Amsterdam, The Netherlands
    Trans R Soc Trop Med Hyg 100:1183-6. 2006
    ..QT-NASBA values declined exponentially and were negative after 6 weeks. Miltefosine plasma concentrations continued to accumulate during the 4 weeks of treatment. The terminal elimination half-life was 14.8 days...
  81. doi Low levels of IgM antibodies against phosphorylcholine predict development of acute myocardial infarction in a population-based cohort from northern Sweden
    Hans Grönlund
    Clinical Immunology and Allergy Unit, Karolinska Institutet and University Hospital, Stockholm, Sweden
    Eur J Cardiovasc Prev Rehabil 16:382-6. 2009
    b>Phosphorylcholine (PC) is one important epitope on oxidized low-density lipoprotein that may play an important role by contributing to the atherogenicity of oxidized low-density lipoprotein...
  82. ncbi Oral miltefosine for leishmaniasis in immunocompromised patients: compassionate use in 39 patients with HIV infection
    Herbert Sindermann
    Medical Research and Development, Zentaris GmbH, Frankfurt am Main, Germany
    Clin Infect Dis 39:1520-3. 2004
    ..Repeated responses after relapse and tolerability of long courses of treatment indicate the potential for development of optimized dosage schemes...
  83. ncbi A novel ATP-binding cassette transporter from Leishmania is involved in transport of phosphatidylcholine analogues and resistance to alkyl-phospholipids
    Esther Castanys-Munoz
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Parque Tecnológico de Ciencias de la Salud, Avda del Conocimiento s n, 18100 Armilla, Granada, Spain
    Mol Microbiol 64:1141-53. 2007
    ..Cross-linking showed dimerization of LiABCG4. These results suggest that LiABCG4 is involved in the active transport of phosphatidylcholine and resistance to alkyl-phospholipids in Leishmania...
  84. ncbi A new class of anticancer alkylphospholipids uses lipid rafts as membrane gateways to induce apoptosis in lymphoma cells
    Arnold H van der Luit
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Mol Cancer Ther 6:2337-45. 2007
    ..Overall, our results suggest that lipid rafts are critical membrane portals for cellular entry of alkylphospholipids depending on SMS1 activity and, therefore, are potential targets for alkylphospholipid anticancer therapy...
  85. doi Natural antibodies against phosphorylcholine as potential protective factors in SLE
    J Su
    Rheumatology Unit, Karolinska University Hospital, Huddinge, Karolinska Institutet corrected Stockholm, Sweden
    Rheumatology (Oxford) 47:1144-50. 2008
    We have recently reported that natural antibodies against phosphorylcholine (anti-PC) have atheroprotective properties. Here we compare anti-PC with other autoantibodies in SLE patients with and without cardiovascular disease (CVD).
  86. pmc Low plasma membrane expression of the miltefosine transport complex renders Leishmania braziliensis refractory to the drug
    María P Sánchez-Cañete
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Parque Tecnológico de Ciencias de la Salud, Armilla, Granada, Spain
    Antimicrob Agents Chemother 53:1305-13. 2009
    ..braziliensis might be prevalent...
  87. pmc Biofilm growth increases phosphorylcholine content and decreases potency of nontypeable Haemophilus influenzae endotoxins
    Shayla West-Barnette
    Department of Microbiology and Immunology, Wake Forest University Health Sciences, 5101A Gray Building, Medical Center Blvd, Winston Salem, NC 27157, USA
    Infect Immun 74:1828-36. 2006
    ..revealed that sialylated variants were distributed throughout the biofilm, while variants expressing phosphorylcholine (PCho) were found within the biofilm...
  88. ncbi Oral miltefosine for the treatment of Indian visceral leishmaniasis
    Shyam Sundar
    Kala azar Medical Research Center, Banaras Hindu University, Varanasi, India
    Trans R Soc Trop Med Hyg 100:S26-33. 2006
    ..5 mg/kg daily for 28 days) was established with a cure rate (94%) similar to that seen in adults. Miltefosine is the first oral antileishmanial drug with a high degree of safety and efficacy for the treatment of VL...
  89. ncbi Rationale and clinical application of alkylphospholipid analogues in combination with radiotherapy
    Stefan R Vink
    Division of Experimental Therapy Department of Radiation Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Cancer Treat Rev 33:191-202. 2007
    ..The preclinical results on molecular targeting underlying this approach will be reviewed, concluded with first clinical data on combined treatment of radiotherapy with perifosine...
  90. pmc Duplicate copies of lic1 direct the addition of multiple phosphocholine residues in the lipopolysaccharide of Haemophilus influenzae
    Kate L Fox
    Molecular Infectious Diseases Group, University of Oxford Department of Paediatrics, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    Infect Immun 76:588-600. 2008
    ..When bound, C-reactive protein leads to complement-mediated killing, indicating the potential biological significance of multiple PCho residues...
  91. ncbi Comparison of miltefosine and meglumine antimoniate for the treatment of zoonotic cutaneous leishmaniasis (ZCL) by a randomized clinical trial in Iran
    M Mohebali
    School of Public Health and Institute of Public Health Research, Medical Sciences University of Tehran, P O Box 14155 6446, Tehran, Iran
    Acta Trop 103:33-40. 2007
    ..major in Iran, based on parasitological as well as clinical criteria two weeks, three months, and six months after end of treatment...
  92. doi New treatment approach in Indian visceral leishmaniasis: single-dose liposomal amphotericin B followed by short-course oral miltefosine
    Shyam Sundar
    Kala azar Medical Research Center, Department of Medicine, Banaras Hindu University, Institute of Medical Sciences, Varanasi, India
    Clin Infect Dis 47:1000-6. 2008
    ....
  93. pmc Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy
    Pauline Chugh
    Department of Microbiology and Immunology, School of Medicine, University of Rochester Medical Center 601 Elmwood Avenue Box 672 Rochester, New York 14742 USA
    Retrovirology 5:11. 2008
    ..Unlike CD4+ T cells, HIV-1 infected macrophages exhibit extended life span even upon stress, consistent with their in vivo role as long-lived HIV-1 reservoirs...
  94. ncbi Miltefosine--discovery of the antileishmanial activity of phospholipid derivatives
    Simon L Croft
    Drugs for Neglected Diseases Initiative DNDi, 1 Place St Gervais, CH 1201 Geneva, Switzerland
    Trans R Soc Trop Med Hyg 100:S4-8. 2006
    ..Miltefosine is active against most Leishmania species, including those that cause cutaneous disease...
  95. ncbi Novel clusters of receptors for sphingosine-1-phosphate, sphingosylphosphorylcholine, and (lyso)-phosphatidic acid: new receptors for "old" ligands
    Evi Kostenis
    7TM Pharma A S, 3 Fremtidsvej, 2970 Hoersholm, Denmark
    J Cell Biochem 92:923-36. 2004
    ..Recently deorphaned lipid receptors, within and outside the known lipid receptor clusters will receive particular attention...
  96. ncbi The peripheral-type benzodiazepine receptor and tumorigenicity: isoquinoline binding protein (IBP) antisense knockdown in the C6 glioma cell line
    Evgeny Levin
    Rappaport Family Institute for Research in the Medical Sciences, Technion Israel Institute of Technology, Haifa, Israel
    Biochemistry 44:9924-35. 2005
    ..In conclusion, our results suggest that enhanced IBP expression, including enhanced PBR ligand binding, such as occurring in untreated C6 glioma cells, may provide a mechanism to increase apoptotic rates of cancer cells...
  97. doi Co-administration of perifosine with paclitaxel synergistically induces apoptosis in ovarian cancer cells: more than just AKT inhibition
    Hui Sun
    Central Lab, Jining First People s Hospital, 6 Jiankang Road, Jining City, Shandong Province 272111, PR China
    Cancer Lett 310:118-28. 2011
    ..These signaling events together caused a marked increase of cancer cell apoptosis. Combining paclitaxel with perifosine may represent a novel anti-ovarian cancer strategy...
  98. ncbi In vitro combination treatment with perifosine and UCN-01 demonstrates synergism against prostate (PC-3) and lung (A549) epithelial adenocarcinoma cell lines
    Girija P Dasmahapatra
    Clinical Trials Unit, Developmental Therapeutics Program, National Cancer Institute, Bethesda, Maryland 20892, USA
    Clin Cancer Res 10:5242-52. 2004
    ..This leads to the hypothesis that these two agents might act synergistically through distinct mechanisms in the PI3K/Akt proliferation and survival-related signaling pathway...
  99. doi Involvement of miltefosine-mediated ERK activation in glioma cell apoptosis through Fas regulation
    Richa Tewari
    National Brain Research Centre, Manesar, Haryana, India
    J Neurochem 107:616-27. 2008
    ..Taken together, our findings suggest the involvement of ERK activation in miltefosine-induced glioma cell apoptosis...
  100. pmc N-glycans of the porcine nematode parasite Ascaris suum are modified with phosphorylcholine and core fucose residues
    Gerald Pöltl
    Department für Chemie, Universität für Bodenkultur, Vienna, Austria
    FEBS J 274:714-26. 2007
    ..parasite Ascaris suum have focused on its glycosphingolipids, which were found, in part, to be modified by phosphorylcholine. Using mass spectrometry and western blotting, we have now analyzed the peptide N-glycosidase A-released N-..
  101. ncbi Lem3p is essential for the uptake and potency of alkylphosphocholine drugs, edelfosine and miltefosine
    Pamela K Hanson
    Department of Physiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 278:36041-50. 2003
    ..These data demonstrate a requirement for Lem3p expression for normal phosphatidylcholine and alkylphosphocholine drug transport across the plasma membrane of yeast...

Research Grants87

  1. BACTERIAL PHOSPHORYLCHOLINE AND PATHOGENESIS
    Jeffrey Weiser; Fiscal Year: 2003
    ..An exception to this rule is the expression of phosphorylcholine (ChoP)...
  2. Deregulated lipid metabolism in stroke
    RAO M ADIBHATLA; Fiscal Year: 2010
    ..The long-range thrust of this research is to develop strategies to minimize disabilities due to stroke. ..
  3. Development of Chemical Receptors for Proteins
    Sanku Mallik; Fiscal Year: 2005
    ..Testing of the synthetic receptors for possible applications in detection of metastatic cancer, imaging and delivery of anti- cancer drugs. ..
  4. CDP-choline: Mechanisms in Cerebral Ischemia
    RAO ADIBHATLA; Fiscal Year: 2006
    ..Arachidonic acid activates neutral sphingomyelinase, resulting in membrane disintegration. PCCT activity was stimulated by exogenous CDP-choline. Aim 2 will be tested in gerbil transient forebrain ischemia. ..
  5. Bacterial biofilms in otitis media
    WILLIAM SWORDS; Fiscal Year: 2009
    ..influenzae biofilms contain sialic acid and phosphorylcholine that contribute to the progression of otitis in a chinchilla middle-ear infection model system...
  6. Bacterial biofilms in otitis media
    WILLIAM SWORDS; Fiscal Year: 2007
    ..influenzae biofilms contain sialic acid and phosphorylcholine that contribute to the progression of otitis in a chinchilla middle-ear infection model system...
  7. Structure-Function Relationships of C-Reactive Protein
    Alok Agrawal; Fiscal Year: 2006
    ..These studies will provide substantial insight into the mechanisms by which this ancient protein may contribute to host defense, or alternatively, to pathogenesis of disease. ..
  8. BIOACTIVITIES OF PNEUMOCOCCAL CELL WALL IN MENINGITIS
    Elaine I Tuomanen; Fiscal Year: 2011
    ..blood brain barrier (CbpA on the cell wall ligates laminin receptor LR) and then penetrates into the CNS (phosphorylcholine PCho on the cell wall ligates platelet activating factor receptor PAFr) and have shown that these steps are ..
  9. GENETICS & VIRULENCE OF PNEUMOCOCCAL CAPSULAR TYPES
    Janet Yother; Fiscal Year: 1993
    ....
  10. Genetic Control of Phospholipid Biosynthesis and Muscular Dystrophy
    Gregory A Cox; Fiscal Year: 2010
    ..The rmd mouse offers the first demonstration of a defect in a phospholipid biosynthetic enzyme causing muscular dystrophy and may reveal unique entry points in which to intervene in the disease process. ..
  11. Bacterial host mimicry and chronic airway infection
    WILLIAM SWORDS; Fiscal Year: 2009
    ..that share certain structural modifications, including the addition of host structures like sialic acid and phosphorylcholine. Data included in this application show that the addition of phosphorylcholine to these endotoxins decreases ..
  12. Genetic Control of Phospholipid Biosynthesis and Muscular Dystrophy
    Gregory Cox; Fiscal Year: 2007
    ..The rmd mouse offers the first demonstration of a defect in a phospholipid biosynthetic enzyme causing muscular dystrophy and may reveal unique entry points in which to intervene in the disease process. ..
  13. MR Based Molecular Imaging of Prostate Cancer
    John Kurhanewicz; Fiscal Year: 2009
    ....
  14. Control of lung permeability by oxidized phospholipids
    Konstantin Birukov; Fiscal Year: 2007
    ..Oxidation of a natural phospholipid component, 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (OxPAPC) reproduces a wide spectrum of physiological effects exerted by oxidized phospholipids...
  15. Competition Among Bacterial Resiratory Pathogens
    Jeffrey Weiser; Fiscal Year: 2004
    ..Both organisms express cell-surface phosphorylcholine (ChoP), an unusual bacterial structure that allows for binding to epithelial cells expressing the receptor ..
  16. C-Reactive Protein in Human Mucosal Immunity
    Jane Gould; Fiscal Year: 2005
    ..It's function in the serum includes binding to phosphorylcholine (ChoP) on the cell wall of Streptococcus pneumoniae, which leads to activation of the complement pathway and ..