phosphorylcholine

Summary

Summary: Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.

Top Publications

  1. ncbi Importance of a biofouling-resistant phospholipid polymer to create a heparinized blood-compatible surface
    Yasuhiko Iwasaki
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Japan
    J Biomater Sci Polym Ed 13:323-35. 2002
  2. ncbi Synthesis and characterisation of cationically modified phospholipid polymers
    Andrew L Lewis
    Biocompatibles UK Ltd, Drug Delivery, Chapman House Farnham Business Park Weydon Lane, Farnham, Surrey GU9 8QL, UK
    Biomaterials 25:3099-108. 2004
  3. ncbi Miltefosine affects lipid metabolism in Leishmania donovani promastigotes
    M Rakotomanga
    Chimiothérapie Antiparasitaire, UMR 8076 CNRS, Faculte de Pharmacie, Universite Paris Sud XI, F 92290 Chatenay Malabry, France
    Antimicrob Agents Chemother 51:1425-30. 2007
  4. ncbi Oral miltefosine for Indian visceral leishmaniasis
    Shyam Sundar
    Institutes of Medical Sciences, Banaras Hindu University, Varanasi, India
    N Engl J Med 347:1739-46. 2002
  5. ncbi Characterisation of Leishmania donovani promastigotes resistant to hexadecylphosphocholine (miltefosine)
    Karin Seifert
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Int J Antimicrob Agents 22:380-7. 2003
  6. ncbi In vitro susceptibility of field isolates of Leishmania donovani to Miltefosine and amphotericin B: correlation with sodium antimony gluconate susceptibility and implications for treatment in areas of endemicity
    Dhiraj Kumar
    Institute of Pathology, Safdarjung Hospital Campus, New Delhi, India
    Antimicrob Agents Chemother 53:835-8. 2009
  7. ncbi Synergistic proapoptotic activity of recombinant TRAIL plus the Akt inhibitor Perifosine in acute myelogenous leukemia cells
    Pier Luigi Tazzari
    Servizio di Immunoematologia e Trasfusionale, Policlinico S Orsola Malpighi, Universita di Bologna, Italy
    Cancer Res 68:9394-403. 2008
  8. ncbi Inactivation of the miltefosine transporter, LdMT, causes miltefosine resistance that is conferred to the amastigote stage of Leishmania donovani and persists in vivo
    Karin Seifert
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Int J Antimicrob Agents 30:229-35. 2007
  9. ncbi B-1 cells: the lineage question revisited
    L A Herzenberg
    Department of Genetics, Stanford University School of Medicine, CA 94305, USA
    Immunol Rev 175:9-22. 2000
  10. ncbi Development of miltefosine as an oral treatment for leishmaniasis
    H Sindermann
    Zentaris GmbH, Weismuellerstrasse 50, 60314 Frankfurt, Germany
    Trans R Soc Trop Med Hyg 100:S17-20. 2006

Research Grants

  1. BACTERIAL PHOSPHORYLCHOLINE AND PATHOGENESIS
    Jeffrey Weiser; Fiscal Year: 2003
  2. Deregulated lipid metabolism in stroke
    RAO M ADIBHATLA; Fiscal Year: 2010
  3. Development of Chemical Receptors for Proteins
    Sanku Mallik; Fiscal Year: 2005
  4. CDP-choline: Mechanisms in Cerebral Ischemia
    RAO ADIBHATLA; Fiscal Year: 2006
  5. Bacterial biofilms in otitis media
    WILLIAM SWORDS; Fiscal Year: 2009
  6. Bacterial biofilms in otitis media
    WILLIAM SWORDS; Fiscal Year: 2007
  7. BIOACTIVITIES OF PNEUMOCOCCAL CELL WALL IN MENINGITIS
    Elaine I Tuomanen; Fiscal Year: 2011
  8. Structure-Function Relationships of C-Reactive Protein
    Alok Agrawal; Fiscal Year: 2006
  9. GENETICS & VIRULENCE OF PNEUMOCOCCAL CAPSULAR TYPES
    Janet Yother; Fiscal Year: 1993
  10. Genetic Control of Phospholipid Biosynthesis and Muscular Dystrophy
    Gregory Cox; Fiscal Year: 2007

Detail Information

Publications282 found, 100 shown here

  1. ncbi Importance of a biofouling-resistant phospholipid polymer to create a heparinized blood-compatible surface
    Yasuhiko Iwasaki
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Japan
    J Biomater Sci Polym Ed 13:323-35. 2002
    ..2-Methacryloyloxyethyl phosphorylcholine (MPC) polymers with 2-aminoethyl methacrylate (AEMA) were synthesized to immobilize heparin through ionic ..
  2. ncbi Synthesis and characterisation of cationically modified phospholipid polymers
    Andrew L Lewis
    Biocompatibles UK Ltd, Drug Delivery, Chapman House Farnham Business Park Weydon Lane, Farnham, Surrey GU9 8QL, UK
    Biomaterials 25:3099-108. 2004
    Phospholipid-like copolymers based on 2-(methacryloyloxyethyl) phosphorylcholine were synthesised using monomer-starved free radical polymerisation methods and incorporating cationic charge in the form of the choline methacrylate monomer ..
  3. ncbi Miltefosine affects lipid metabolism in Leishmania donovani promastigotes
    M Rakotomanga
    Chimiothérapie Antiparasitaire, UMR 8076 CNRS, Faculte de Pharmacie, Universite Paris Sud XI, F 92290 Chatenay Malabry, France
    Antimicrob Agents Chemother 51:1425-30. 2007
    ....
  4. ncbi Oral miltefosine for Indian visceral leishmaniasis
    Shyam Sundar
    Institutes of Medical Sciences, Banaras Hindu University, Varanasi, India
    N Engl J Med 347:1739-46. 2002
    ..Miltefosine may be particularly advantageous because it can be administered orally. It may also be helpful in regions where parasites are resistant to current agents...
  5. ncbi Characterisation of Leishmania donovani promastigotes resistant to hexadecylphosphocholine (miltefosine)
    Karin Seifert
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Int J Antimicrob Agents 22:380-7. 2003
    ..Resistance was stable up to 12 weeks in drug-free culture medium. No amplification of specific genes, including the multidrug resistance P-glycoprotein gene, could be detected in the resistant parasites...
  6. ncbi In vitro susceptibility of field isolates of Leishmania donovani to Miltefosine and amphotericin B: correlation with sodium antimony gluconate susceptibility and implications for treatment in areas of endemicity
    Dhiraj Kumar
    Institute of Pathology, Safdarjung Hospital Campus, New Delhi, India
    Antimicrob Agents Chemother 53:835-8. 2009
    ..The results of gene expression analysis of LdMT and LdRos3 were suggestive of alternate mechanisms of Miltefosine susceptibility in the isolates...
  7. ncbi Synergistic proapoptotic activity of recombinant TRAIL plus the Akt inhibitor Perifosine in acute myelogenous leukemia cells
    Pier Luigi Tazzari
    Servizio di Immunoematologia e Trasfusionale, Policlinico S Orsola Malpighi, Universita di Bologna, Italy
    Cancer Res 68:9394-403. 2008
    ..In contrast, CD34(+) cells from healthy donors were resistant to perifosine and TRAIL treatment. Our findings suggest that the combination of perifosine and TRAIL might offer a novel therapeutic strategy for AML...
  8. ncbi Inactivation of the miltefosine transporter, LdMT, causes miltefosine resistance that is conferred to the amastigote stage of Leishmania donovani and persists in vivo
    Karin Seifert
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Int J Antimicrob Agents 30:229-35. 2007
    ..90% inhibition in wild-type infections). No cross-resistance to other antileishmanial drugs was observed in M-mutR amastigotes...
  9. ncbi B-1 cells: the lineage question revisited
    L A Herzenberg
    Department of Genetics, Stanford University School of Medicine, CA 94305, USA
    Immunol Rev 175:9-22. 2000
    ....
  10. ncbi Development of miltefosine as an oral treatment for leishmaniasis
    H Sindermann
    Zentaris GmbH, Weismuellerstrasse 50, 60314 Frankfurt, Germany
    Trans R Soc Trop Med Hyg 100:S17-20. 2006
    ..It is therefore contraindicated for use during pregnancy, and contraception is required beyond the end of treatment in women of child-bearing age...
  11. ncbi Pharmacokinetics of miltefosine in Old World cutaneous leishmaniasis patients
    Thomas P C Dorlo
    Department of Pharmacy and Pharmacology, Slotervaart Hospital The Netherlands Cancer Institute, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands
    Antimicrob Agents Chemother 52:2855-60. 2008
    ....
  12. ncbi Comparison of short-course multidrug treatment with standard therapy for visceral leishmaniasis in India: an open-label, non-inferiority, randomised controlled trial
    Shyam Sundar
    Kala azar Medical Research Center, Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
    Lancet 377:477-86. 2011
    ..Improved treatment approaches are needed for visceral leishmaniasis. We assessed the efficacy and safety of three potential short-course combination treatments compared with the standard monotherapy in India...
  13. ncbi Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor
    D R Cundell
    Laboratory of Molecular Infectious Diseases, Rockefeller University, New York, New York 10021 6399, USA
    Nature 377:435-8. 1995
    ..Only virulent pneumococci engage the PAF receptor. Attachment of the bacterial phosphorylcholine to the PAF receptor enhanced adherence, which was coupled to invasion of endothelial, epithelial and PAF-..
  14. ncbi Possible mechanism of miltefosine-mediated death of Leishmania donovani
    Navin K Verma
    Department of Biotechnology, National Institute of Pharmaceutical Education and Research, Punjab, India
    Antimicrob Agents Chemother 48:3010-5. 2004
    ..Understanding of miltefosine-mediated death will facilitate the design of new therapeutic strategies against Leishmania parasites...
  15. ncbi Sensitivities of Leishmania species to hexadecylphosphocholine (miltefosine), ET-18-OCH(3) (edelfosine) and amphotericin B
    Patricia Escobar
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Acta Trop 81:151-7. 2002
    ..5-37.1 microM against amastigotes. Amphotericin B deoxycholate was used as the standard drug and gave submicromolar ED(50) values in all assays; L. mexicana was the least sensitive species to this drug...
  16. ncbi Phase II study of perifosine in previously untreated patients with metastatic melanoma
    D Scott Ernst
    London Regional Cancer Centre, 790 Commissioners Rd East, London, ON N6A 4L6, UK
    Invest New Drugs 23:569-75. 2005
    ..To assess the response rate and toxicity of the alkylphosphocholine analogue, perifosine, in patients with metastatic or recurrent malignant melanoma...
  17. ncbi Phase 4 trial of miltefosine for the treatment of Indian visceral leishmaniasis
    Sujit Kumar Bhattacharya
    Rajendra Memorial Research Institute of Medical Sciences, Agam Kuan, India
    J Infect Dis 196:591-8. 2007
    ..Hospital-based studies have shown that oral miltefosine is a highly effective treatment for VL both in adults and in children...
  18. ncbi Alteration of fatty acid and sterol metabolism in miltefosine-resistant Leishmania donovani promastigotes and consequences for drug-membrane interactions
    M Rakotomanga
    , UMR 8076 CNRS, , , F-92290, Chātenay-Malabry, France
    Antimicrob Agents Chemother 49:2677-86. 2005
    ..In conclusion, HePC resistance affects three lipid biochemical pathways: fatty acid elongation, the desaturase system responsible for fatty acid alkyl chain unsaturation, and the C-24-alkylation of sterols...
  19. ncbi Mechanisms of experimental resistance of Leishmania to miltefosine: Implications for clinical use
    F Javier Pérez-Victoria
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Spanish Research Council C S I C, Technological Park of Health Sciences, Avda del Conocimiento s n, 18100 Armilla, Granada, Spain
    Drug Resist Updat 9:26-39. 2006
    ....
  20. ncbi Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo
    Hiroyuki Momota
    Department of Cancer Biology and Genetics and Surgery (Neurosurgery) and Neurology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 65:7429-35. 2005
    ..01). These results indicate that perifosine is an effective drug in gliomas in which Akt and Ras-Erk 1/2 pathways are frequently activated, and may be a new candidate for glioma treatment in the clinic...
  21. ncbi Decoration of lipopolysaccharide with phosphorylcholine: a phase-variable characteristic of Haemophilus influenzae
    J N Weiser
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 19104 4318, USA
    Infect Immun 65:943-50. 1997
    ..Incorporated choline is in the form of phosphorylcholine (ChoP) based on the reactivity with the monoclonal antibody with specificity for this structure, TEPC-15...
  22. ncbi Increased junctional diversity in fetal B cells results in a loss of protective anti-phosphorylcholine antibodies in adult mice
    C L Benedict
    Department of Microbiology, University of Alabama at Birmingham, 35294 3300, USA
    Immunity 10:607-17. 1999
    ..These results show that maintenance of lower Ig diversity in early life is essential for the acquisition of a complete functional adult repertoire...
  23. ncbi Low levels of antibodies against phosphorylcholine predict development of stroke in a population-based study from northern Sweden
    Roland Fiskesund
    Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
    Stroke 41:607-12. 2010
    Natural immunoglobulin M antibodies specific for phosphorylcholine (anti-PC) have been implicated in atherosclerosis...
  24. ncbi Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species
    Mohamed Rahmani
    Department of Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, USA
    Cancer Res 65:2422-32. 2005
    ..They also raise the possibility that combining these agents may represent a novel antileukemic strategy...
  25. ncbi Anticancer alkylphospholipids: mechanisms of action, cellular sensitivity and resistance, and clinical prospects
    Wim J van Blitterswijk
    Division of Cellular Biochemistry, Department of Radiotherapy, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Curr Pharm Des 14:2061-74. 2008
    ..For example, ALPs increase the cancer cell sensitivity to radiotherapy in vitro and in vivo. We highlight the clinical potential of perifosine, an orally available APL...
  26. ncbi Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment
    David Gallego-Ortega
    Translational Oncology Unit, CSIC UAM La Paz, Instituto de Investigaciones Biomedicas, Madrid, Spain
    PLoS ONE 4:e7819. 2009
    ..Recently ChoKalpha has been implicated in the carcinogenic process, since it is over-expressed in a variety of human cancers. However, no evidence for a role of ChoKbeta in carcinogenesis has been reported...
  27. ncbi Changes in choline metabolism as potential biomarkers of phospholipase C{gamma}1 inhibition in human prostate cancer cells
    Mounia Beloueche-Babari
    Cancer Research UK Clinical Magnetic Resonance Research Group, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom
    Mol Cancer Ther 8:1305-11. 2009
    ....
  28. ncbi Perifosine: update on a novel Akt inhibitor
    Joell J Gills
    Medical Oncology Branch, National Cancer Institute, NNMC Building 8, Room 5101, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA
    Curr Oncol Rep 11:102-10. 2009
    ..In this article, we review the clinical history of perifosine and discuss its many biologic activities...
  29. ncbi Perifosine synergistically enhances TRAIL-induced myeloma cell apoptosis via up-regulation of death receptors
    Ebenezer David
    Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA
    Clin Cancer Res 14:5090-8. 2008
    ..The aim of this study is to investigate the efficacy of a novel Akt inhibitor, perifosine, in combination with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in human myeloma cells and primary patient samples...
  30. ncbi The sensitivity of clinical isolates of Leishmania from Peru and Nepal to miltefosine
    Vanessa Yardley
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Am J Trop Med Hyg 73:272-5. 2005
    ..If this model can be correlated to therapeutic outcome, it may have implications for the interpretation of clinical trials...
  31. ncbi Treatment of New World cutaneous leishmaniasis with miltefosine
    J Soto
    , Calle 60 A 5-54 Suite 201, Bogot, Colombia
    Trans R Soc Trop Med Hyg 100:S34-40. 2006
    ..Miltefosine was well tolerated, and as effective as historic values of antimony for treatment of L. panamensis disease...
  32. ncbi Phosphorylcholine on the lipopolysaccharide of Haemophilus influenzae contributes to persistence in the respiratory tract and sensitivity to serum killing mediated by C-reactive protein
    J N Weiser
    Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Exp Med 187:631-40. 1998
    Haemophilus influenzae undergoes phase variation in expression of the phosphorylcholine (ChoP) epitope, a structure present on several invasive pathogens residing in the human respiratory tract...
  33. ncbi Miltefosine treatment of Leishmania major infection: an observational study involving Dutch military personnel returning from northern Afghanistan
    P P A M van Thiel
    Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS and Center for Infection and Immunity, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Clin Infect Dis 50:80-3. 2010
    ..Thirty patients experienced cure after receipt of miltefosine, 3 after receipt of additional ilSb(v), and 1 after 28 daily intravenous injections of antimony. Temporary diminution of ejaculate volume was reported by 21 patients...
  34. ncbi Miltefosine, a promising novel agent for schistosomiasis mansoni
    Maha M Eissa
    Department of Medical Parasitology, Faculty of Medicine, Alexandria University, Alexandria, Egypt
    Int J Parasitol 41:235-42. 2011
    ..In conclusion, we believe this is the first study highlighting miltefosine as a promising novel agent for schistosomiasis mansoni...
  35. ncbi Increased prevalence of vulnerable atherosclerotic plaques and low levels of natural IgM antibodies against phosphorylcholine in patients with systemic lupus erythematosus
    Cristina Anania
    Department of Medicine, Karolinska University Hospital, Huddinge, 141 86 Stockholm, Sweden
    Arthritis Res Ther 12:R214. 2010
    ..We recently reported a negative association between natural IgM-antibodies against phosphorylcholine (anti-PC) in the general population, high anti-PC levels leading to decreased atherosclerosis development ..
  36. ncbi Phosphocholine and sphingosine-1-phosphate synergistically stimulate DNA synthesis by a MAP kinase-dependent mechanism
    Z Kiss
    The Hormel Institute, University of Minnesota, Austin 55912, USA
    FEBS Lett 412:197-200. 1997
    ....
  37. ncbi First case of typical Old World cutaneous leishmaniasis treated with miltefosine
    Marija Stojkovic
    Section of Clinical Tropical Medicine, Heidelberg University Hospital, Heidelberg, and General Practice, Dreisamstr 11, Freiburg, Germany
    Int J Dermatol 46:385-7. 2007
    ..Ten days after completion of treatment, the rolled edge had disappeared and the central ulcer had almost healed (Fig. 3). Figure 4 shows the lesion 5 months after completion of treatment...
  38. ncbi Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells
    V Papa
    Dipartimento di Scienze Anatomiche Umane e Fisiopatologia dell Apparato Locomotore, Universita di Bologna, Bologna, Italy
    Leukemia 22:147-60. 2008
    ..Our findings indicate that perifosine, either alone or in combination with existing drugs, might be a promising therapeutic agent for the treatment of those AML cases characterized by upregulation of the PI3K-Akt survival pathway...
  39. ncbi Visceral leishmaniasis: elimination with existing interventions
    Greg Matlashewski
    Special Programme for Research and Training in Tropical Diseases, WHO, Geneva, Switzerland
    Lancet Infect Dis 11:322-5. 2011
    ....
  40. ncbi Transition from octahedral to tetrahedral geometry causes the activation or inhibition by Znf2+ of Pseudomonas aeruginosa phosphorylcholine phosphatase
    Lisandro H Otero
    Departamento de Biologia Molecular, Universidad Nacional de Rio Cuarto, 5800 Rio Cuarto, Cordoba, Argentina
    Biometals 23:307-14. 2010
    Pseudomonas aeruginosa phosphorylcholine phosphatase (PchP) catalyzes the hydrolysis of phosphorylcholine, which is produced by the action of hemolytic phospholipase C on phosphatidylcholine or sphyngomielin, to generate choline and ..
  41. ncbi Quantification of the response to miltefosine treatment for visceral leishmaniasis by QT-NASBA
    P J de Vries
    Academic Medical Center, Division of Infectious Diseases, Tropical Medicine and AIDS, Meibergdreef 9, Amsterdam, The Netherlands
    Trans R Soc Trop Med Hyg 100:1183-6. 2006
    ..QT-NASBA values declined exponentially and were negative after 6 weeks. Miltefosine plasma concentrations continued to accumulate during the 4 weeks of treatment. The terminal elimination half-life was 14.8 days...
  42. ncbi Sphingosylphosphorylcholine inhibits melanin synthesis via pertussis toxin-sensitive MITF degradation
    Dong Seok Kim
    Department of Biochemistry, Chung Ang University College of Medicine, Seoul, Republic of Korea
    J Pharm Pharmacol 62:181-7. 2010
    ..In this study we aimed to examine sphingosylphosphorylcholine-mediated signalling pathways related to melanogenesis...
  43. ncbi The acute-phase reactant C-reactive protein binds to phosphorylcholine-expressing Neisseria meningitidis and increases uptake by human phagocytes
    Rosalyn Casey
    Division of Microbial Sciences, Faculty of Health and Medical Sciences, University of Surrey, Stag Hill, Guildford, Surrey GU2 7XH, United Kingdom
    Infect Immun 76:1298-304. 2008
    ..has been shown to help protect the host from several bacterial pathogens, which it recognizes by binding to phosphorylcholine (PC) on their surfaces...
  44. ncbi Anti-acanthamoeba efficacy and toxicity of miltefosine in an organotypic skin equivalent
    Julia Walochnik
    Department of Medical Parasitology, Institute of Hygiene, Medical University of Vienna, 1095 Vienna, Austria
    J Antimicrob Chemother 64:539-45. 2009
    ..in vitro. The aim of the current study was to evaluate the suitability of miltefosine for the topical treatment of Acanthamoeba infections...
  45. ncbi Comparison of miltefosine and meglumine antimoniate for the treatment of zoonotic cutaneous leishmaniasis (ZCL) by a randomized clinical trial in Iran
    M Mohebali
    School of Public Health and Institute of Public Health Research, Medical Sciences University of Tehran, P O Box 14155 6446, Tehran, Iran
    Acta Trop 103:33-40. 2007
    ..major in Iran, based on parasitological as well as clinical criteria two weeks, three months, and six months after end of treatment...
  46. ncbi Miltefosine induces apoptosis-like death in Leishmania donovani promastigotes
    Caroline Paris
    UMR 8076 CNRS, , France
    Antimicrob Agents Chemother 48:852-9. 2004
    ..Identification of the death-signaling pathways activated in HePC-sensitive parasites appears to be essential for a better understanding of the molecular mechanisms of action and resistance in these parasites...
  47. ncbi Rationale and clinical application of alkylphospholipid analogues in combination with radiotherapy
    Stefan R Vink
    Division of Experimental Therapy Department of Radiation Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Cancer Treat Rev 33:191-202. 2007
    ..The preclinical results on molecular targeting underlying this approach will be reviewed, concluded with first clinical data on combined treatment of radiotherapy with perifosine...
  48. ncbi Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy
    Pauline Chugh
    Department of Microbiology and Immunology, School of Medicine, University of Rochester Medical Center 601 Elmwood Avenue Box 672 Rochester, New York 14742 USA
    Retrovirology 5:11. 2008
    ..Unlike CD4+ T cells, HIV-1 infected macrophages exhibit extended life span even upon stress, consistent with their in vivo role as long-lived HIV-1 reservoirs...
  49. ncbi New treatment approach in Indian visceral leishmaniasis: single-dose liposomal amphotericin B followed by short-course oral miltefosine
    Shyam Sundar
    Kala azar Medical Research Center, Department of Medicine, Banaras Hindu University, Institute of Medical Sciences, Varanasi, India
    Clin Infect Dis 47:1000-6. 2008
    ....
  50. ncbi Duplicate copies of lic1 direct the addition of multiple phosphocholine residues in the lipopolysaccharide of Haemophilus influenzae
    Kate L Fox
    Molecular Infectious Diseases Group, University of Oxford Department of Paediatrics, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    Infect Immun 76:588-600. 2008
    ..When bound, C-reactive protein leads to complement-mediated killing, indicating the potential biological significance of multiple PCho residues...
  51. ncbi Miltefosine--discovery of the antileishmanial activity of phospholipid derivatives
    Simon L Croft
    Drugs for Neglected Diseases Initiative DNDi, 1 Place St Gervais, CH 1201 Geneva, Switzerland
    Trans R Soc Trop Med Hyg 100:S4-8. 2006
    ..Miltefosine is active against most Leishmania species, including those that cause cutaneous disease...
  52. ncbi Involvement of miltefosine-mediated ERK activation in glioma cell apoptosis through Fas regulation
    Richa Tewari
    National Brain Research Centre, Manesar, Haryana, India
    J Neurochem 107:616-27. 2008
    ..Taken together, our findings suggest the involvement of ERK activation in miltefosine-induced glioma cell apoptosis...
  53. ncbi Lem3p is essential for the uptake and potency of alkylphosphocholine drugs, edelfosine and miltefosine
    Pamela K Hanson
    Department of Physiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 278:36041-50. 2003
    ..These data demonstrate a requirement for Lem3p expression for normal phosphatidylcholine and alkylphosphocholine drug transport across the plasma membrane of yeast...
  54. ncbi Low levels of IgM antibodies to phosphorylcholine predict cardiovascular disease in 60-year old men: effects on uptake of oxidized LDL in macrophages as a potential mechanism
    Ulf de Faire
    Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Autoimmun 34:73-9. 2010
    We here determine the role of IgM antibodies against phosphorylcholine (anti-PC) in prediction of cardiovascular disease (CVD) and on macrophage uptake of Oxidized LDL (OxLDL).
  55. ncbi In vitro combination treatment with perifosine and UCN-01 demonstrates synergism against prostate (PC-3) and lung (A549) epithelial adenocarcinoma cell lines
    Girija P Dasmahapatra
    Clinical Trials Unit, Developmental Therapeutics Program, National Cancer Institute, Bethesda, Maryland 20892, USA
    Clin Cancer Res 10:5242-52. 2004
    ..CONCLUSIONS: As the concentrations of UCN-01 and perifosine causing synergistic inhibition of cell growth are clinically achievable without prominent toxicity, these data support the development of clinical studies with this combination...
  56. ncbi Oral miltefosine for the treatment of Indian visceral leishmaniasis
    Shyam Sundar
    Kala azar Medical Research Center, Banaras Hindu University, Varanasi, India
    Trans R Soc Trop Med Hyg 100:S26-33. 2006
    ..5 mg/kg daily for 28 days) was established with a cure rate (94%) similar to that seen in adults. Miltefosine is the first oral antileishmanial drug with a high degree of safety and efficacy for the treatment of VL...
  57. ncbi N-glycans of the porcine nematode parasite Ascaris suum are modified with phosphorylcholine and core fucose residues
    Gerald Pöltl
    Department für Chemie, Universität für Bodenkultur, Vienna, Austria
    FEBS J 274:714-26. 2007
    ..parasite Ascaris suum have focused on its glycosphingolipids, which were found, in part, to be modified by phosphorylcholine. Using mass spectrometry and western blotting, we have now analyzed the peptide N-glycosidase A-released N-..
  58. ncbi Low plasma membrane expression of the miltefosine transport complex renders Leishmania braziliensis refractory to the drug
    María P Sánchez-Cañete
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Parque Tecnológico de Ciencias de la Salud, Armilla, Granada, Spain
    Antimicrob Agents Chemother 53:1305-13. 2009
    ..braziliensis might be prevalent...
  59. ncbi Low levels of IgM antibodies against phosphorylcholine-A potential risk marker for ischemic stroke in men
    Beatrice G Sjöberg
    Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
    Atherosclerosis 203:528-32. 2009
    Natural antibodies specific for phosphorylcholine (anti-PC) have been implicated as protective factors in atherosclerosis. We herein determined the relationship between IgM anti-PC and incidence of cardiovascular disease (CVD).
  60. ncbi Thermodynamics of phosphorylcholine and lysophosphatidylcholine binding to the major protein of bovine seminal plasma, PDC-109
    V Anbazhagan
    School of Chemistry, University of Hyderabad, India
    FEBS Lett 579:2933-8. 2005
    ..The binding of phosphorylcholine (PrC) and lysophosphatidylcholine (Lyso-PC) with PDC-109 was investigated by monitoring the ligand-induced ..
  61. ncbi Phosphorylcholine expression by nontypeable Haemophilus influenzae correlates with maturation of biofilm communities in vitro and in vivo
    Wenzhou Hong
    Department of Microbiology and Immunology, Wake Forest University Health Sciences, 5101A Gray Building, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Bacteriol 189:8300-7. 2007
    ..NTHI variants within biofilms have on their surfaces lipooligosaccharides containing sialic acid (NeuAc) and phosphorylcholine (PCho)...
  62. ncbi Radiosensitization of squamous cell carcinoma by the alkylphospholipid perifosine in cell culture and xenografts
    Stefan R Vink
    Division of Experimental Therapy and Cellular Biochemistry, The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Clin Cancer Res 12:1615-22. 2006
    ..These data provide strong support for further development of this combination in clinical studies...
  63. ncbi Enzyme-degradable phosphorylcholine porous hydrogels cross-linked with polyphosphoesters for cell matrices
    Chookaet Wachiralarpphaithoon
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2 3 10 Kanda surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    Biomaterials 28:984-93. 2007
    Biodegradable highly porous hydrogels composed of poly [2-methacryloyloxyethyl phosphorylcholine (MPC)] cross-linked with polyphosphoesters have been prepared as novel cellular matrices...
  64. ncbi Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma
    Oren J Becher
    Departments of Cancer Biology and Genetics, Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 70:2548-57. 2010
    ..92). Perifosine + 10 Gy did not result in a significantly increased survival relative to 10 Gy alone (P = 0.23). This PDGF-induced BSG model can serve as a preclinical tool for the testing of novel agents...
  65. ncbi Using a molecular model and kinetic experiments in the presence of divalent cations to study the active site and catalysis of Pseudomonas aeruginosa phosphorylcholine phosphatase
    Paola R Beassoni
    Departamento de Biologia Molecular, Universidad Nacional de Rio Cuarto, 5800 Rio Cuarto, Cordoba, Argentina
    Biochim Biophys Acta 1784:2038-44. 2008
    b>Phosphorylcholine phosphatase (PchP) of Pseudomonas aeruginosa, a product of the PA5292 gene, catalyzes the hydrolysis of phosphocholine to choline and inorganic phosphate (Pi)...
  66. ncbi A phase II study of perifosine in androgen independent prostate cancer
    Edwin M Posadas
    Medical Oncology Clinical Research Unit, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    Cancer Biol Ther 4:1133-7. 2005
    ..No significant clinical activity against prostate cancer was observed. This agent does not merit further study in the setting of monotherapy in this population...
  67. ncbi Crossreactivity of human anti-dsDNA antibodies to phosphorylcholine: clues to their origin
    A Sharma
    Bloomsbury Rheumatology Unit/Centre for Rheumatology, Dept of Medicine, University College London, Arthur Stanley House, London, W1P 9PG, UK
    J Autoimmun 16:479-84. 2001
    ..In particular, anti-DNA antibodies have been shown to crossreact with phosphorylcholine (PC), a dominant epitope on pneumococcal cell wall polysaccharide...
  68. ncbi Development and validation of a quantitative assay for the measurement of miltefosine in human plasma by liquid chromatography-tandem mass spectrometry
    Thomas P C Dorlo
    Department of Pharmacy and Pharmacology, Slotervaart Hospital The Netherlands Cancer Institute, Louwesweg 6, 1066 EC Amsterdam, The Netherlands
    J Chromatogr B Analyt Technol Biomed Life Sci 865:55-62. 2008
    ..At the lowest level, the intra-assay precision was lower than 10.7%, the inter-assay precision was 10.6% and accuracies were between 95.1 and 109%. This assay is successfully used in a clinical pharmacokinetic study with miltefosine...
  69. ncbi Site-directed mutations and kinetic studies show key residues involved in alkylammonium interactions and reveal two sites for phosphorylcholine in Pseudomonas aeruginosa phosphorylcholine phosphatase
    Paola R Beassoni
    Departamento de Biologia Molecular, Universidad Nacional de Rio Cuarto, X5800BYA Río Cuarto, Cordoba, Argentina
    Biochim Biophys Acta 1814:858-63. 2011
    Pseudomonas aeruginosa phosphorylcholine phosphatase (PchP) catalyzes the hydrolysis of phosphorylcholine (Pcho) to produce choline and inorganic phosphate...
  70. ncbi Rapid development of hydrophilicity and protein adsorption resistance by polymer surfaces bearing phosphorylcholine and naphthalene groups
    Koji Futamura
    Department of Materials Engineering, Department of Bioengineering, School of Engineering, Center for NanoBio Integration, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Langmuir 24:10340-4. 2008
    ..protein solution under completely dry conditions, a new phospholipid copolymer, poly (2-methacryloyloxyethyl phosphorylcholine (MPC)- co-2-vinylnaphthalene (vN)) (PMvN), was synthesized...
  71. ncbi Identification, cloning, and expression of Pseudomonas aeruginosa phosphorylcholine phosphatase gene
    Maria J Massimelli
    Departamento de Biologia Molecular, Facultad de Ciencias Exactas, Fisicoquímicas y Naturales, Universidad Nacional de Rio Cuarto, 5800, Rio Cuarto, Cordoba, Argentina
    Curr Microbiol 50:251-6. 2005
    Pseudomonas aeruginosa phosphorylcholine phosphatase (PChP) is a periplasmic enzyme produced simultaneously with the hemolytic phospholipase C (PLc-H) when the bacteria are grown in the presence of choline, betaine, dimethylglycine or ..
  72. ncbi Sphingosylphosphorylcholine is a Melanogenic Stimulator for Human Melanocytes
    Kazuhiko Higuchi
    Department of Dermatology, Tokyo Women's Medical University, Tokyo, Japan
    Pigment Cell Res 16:670-8. 2003
    ..These results suggest that SPC may be a melanogenic stimulator of human melanocytes inducing the coordinated upregulated expression of various melanogenic molecules, including c-kit...
  73. ncbi Glucantime-resistant Leishmania tropica isolated from Iranian patients with cutaneous leishmaniasis are sensitive to alternative antileishmania drugs
    R Hadighi
    Department of Parasitology, Faculty of Medicine, Iran University of Medical Sciences, 14496, Tehran, Iran
    Parasitol Res 101:1319-22. 2007
    ..However, these resistant isolates were shown to be sensitive to miltefosine and paromomycin. The latter two drugs could thus be useful alternatives for the treatment of leishmaniasis in Iran even for SbV-resistant isolates...
  74. ncbi Evaluation of 2-methacryloyloxyethyl phosphorylcholine polymeric nanoparticle for immunoassay of C-reactive protein detection
    Jongwon Park
    Department of Materials Engineering, School of Engineering, The University of Tokyo, Tokyo, Japan
    Anal Chem 76:2649-55. 2004
    To prepare novel 2-methacryloyloxyethyl phosphorylcholine (MPC)-polymeric nanoparticle (MPC-PNP), water-soluble amphiphilic phospholipid polymer, poly [MPC-co-n-butyl methacrylate (BMA)-co-p-nitrophenyloxycarbonyl poly(ethylene glycol) ..
  75. ncbi Choline catabolism, σ⁵⁴ factor and NtrC are required for the full expression of the Pseudomonas aeruginosa phosphorylcholine phosphatase gene
    Maria J Massimelli
    Departamento de Biologia Molecular, FCEFQN, Universidad Nacional de Rio Cuarto, Ruta 36 Km 601, 5800 Rio Cuarto, Cordoba, Argentina
    Microbiol Res 166:380-90. 2011
    Choline favors the pathogenesis of Pseudomonas aeruginosa because hemolytic phospholipase C and phosphorylcholine phosphatase (PchP) are synthesized as a consequence of its catabolism...
  76. ncbi How do nematodes transfer phosphorylcholine to carbohydrates?
    William Harnett
    Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, UK
    Trends Parasitol 26:114-8. 2010
    An unusual aspect of the biology of nematodes is the attachment of phosphorylcholine (PC) to carbohydrate. The attachment appears to play an important role in nematode development and, in some parasitic species, in immunomodulation...
  77. ncbi Controlled delivery of antisense oligodeoxynucleotide from cationically modified phosphorylcholine polymer films
    ZhuoQi Zhang
    Biological Physics Group, School of Physics and Astronomy, The University of Manchester, Sackville Street Building, Sackville Street, Manchester M60 1QD, UK
    Biomacromolecules 7:784-91. 2006
    ..In this study, phosphorylcholine (PC) polymer films bearing different cationic charge densities were deposited onto smooth silicon substrates...
  78. ncbi Isolation and characterization of heparin- and phosphorylcholine-binding proteins of boar and stallion seminal plasma. Primary structure of porcine pB1
    J J Calvete
    Institut für Reproduktionsmedizin, Tierarztliche Hochschule Hannover, Hannover Kirchrode, Germany
    FEBS Lett 407:201-6. 1997
    In the bovine, seminal plasma heparin-binding proteins bind to sperm lipids containing the phosphorylcholine group and mediate the capacitating effects of heparin-like glycosaminoglycans during sperm residence in the female genital tract...
  79. ncbi Sphingosylphosphorylcholine-induced ERK activation inhibits melanin synthesis in human melanocytes
    Dong Seok Kim
    Research Division for Human Life Sciences, Seoul National University, 28 Yongon Dong, Chongno Gu, Seoul 110 744, South Korea
    Pigment Cell Res 19:146-53. 2006
    ..These results suggest that the ERK pathway is involved in the melanogenic signaling cascade, and that ERK activation by SPC reduces melanin synthesis via MITF downregulation...
  80. ncbi Low level natural antibodies against phosphorylcholine: a novel risk marker and potential mechanism in atherosclerosis and cardiovascular disease
    Johan Frostegard
    Department of Medicine, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden
    Clin Immunol 134:47-54. 2010
    ..A common denominator is phosphorylcholine (PC), a hapten-like epitope which is exposed on OxLDL and some microorganisms...
  81. ncbi Regeneration of functional nerves within full thickness collagen-phosphorylcholine corneal substitute implants in guinea pigs
    Christopher R McLaughlin
    University of Ottawa Eye Institute, The Ottawa Hospital, General Campus, 501 Smyth Road, Ottawa, ONK1H 8L6, Canada
    Biomaterials 31:2770-8. 2010
    ..Porcine type I collagen and 2-methacryloyloxyethyl phosphorylcholine (MPC) were crosslinked using 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide (EDC) and N-hydroxysuccinimide (..
  82. ncbi Collagen-phosphorylcholine interpenetrating network hydrogels as corneal substitutes
    Wenguang Liu
    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Biomaterials 30:1551-9. 2009
    ..crosslinked porcine atelocollagen, and poly(ethylene glycol) diacrylate crosslinked 2-methacryloyloxyethyl phosphorylcholine (MPC)...
  83. ncbi Development of miltefosine for the leishmaniases
    J D Berman
    National Center for Complementary and Alternative Medicine, National Institutes of Health, 6707 Democracy Blvd, Suite 401, Bethesda MD, 20892 USA
    Mini Rev Med Chem 6:145-51. 2006
    ..Miltefosine (hexadecylephosphocholine) is the first oral agent that is effective and tolerated for both visceral and cutaneous disease in several endemic regions, and represents a major advance in the treatment of these diseases...
  84. ncbi Preparation and biophysical characterization of recombinant Pseudomonas aeruginosa phosphorylcholine phosphatase
    Paola R Beassoni
    Departamento de Biologia Molecular, Universidad Nacional de Rio Cuarto, Rio Cuarto, Cordoba, Argentina
    Protein Expr Purif 71:153-9. 2010
    ..aeruginosa infections constitute a widespread health problem with high economical and social impact, and the phosphorylcholine phosphatase (PchP) of this bacterium is a potential target for antimicrobial treatment...
  85. ncbi The M603 idiotype is lost in the response to phosphocholine in terminal deoxynucleotidyl transferase-deficient mice
    Qing Sheng Mi
    Laboratory of Immunology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore 21224, USA
    Eur J Immunol 32:1139-46. 2002
    ..These data indicate that production of M603-id antibody is TdT dependent, while generation of M167-id antibody is TdT independent, and that in the absence of competition from M603-like B cells, T15-id B cells can respond to PC-PM...
  86. ncbi Construction of viscoelastic biocompatible films via the layer-by-layer assembly of hyaluronan and phosphorylcholine-modified chitosan
    Piotr Kujawa
    Faculté de Pharmacie and Département de Chimie, Universite de Montreal, C P 6128 Succursale Centre Ville, Montreal, Quebec, Canada
    Biomacromolecules 8:3169-76. 2007
    Films of hyaluronan (HA) and a phosphorylcholine-modified chitosan (PC-CH) were constructed by the polyelectrolyte multilayer (PEM) deposition technique and their buildup in 0...
  87. ncbi In vitro activity of hexadecylphosphocholine (miltefosine) against metronidazole-resistant and -susceptible strains of Trichomonas vaginalis
    C Blaha
    Department of Medical Parasitology, Clinical Institute of Hygiene and Medical Microbiology, Medical University of Vienna, Kinderspitalgasse 15, 1095 Vienna, Austria
    J Antimicrob Chemother 57:273-8. 2006
    ..Treatment of trichomonads with HePC resulted in rounding up and, at concentrations of >or=40 microM, in subsequent total lysis of the organisms. CONCLUSIONS: HePC may be a promising new candidate for the treatment of trichomoniasis...
  88. ncbi A new class of anticancer alkylphospholipids uses lipid rafts as membrane gateways to induce apoptosis in lymphoma cells
    Arnold H van der Luit
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Mol Cancer Ther 6:2337-45. 2007
    ..Overall, our results suggest that lipid rafts are critical membrane portals for cellular entry of alkylphospholipids depending on SMS1 activity and, therefore, are potential targets for alkylphospholipid anticancer therapy...
  89. ncbi In vitro bactericidal activity of the antiprotozoal drug miltefosine against Streptococcus pneumoniae and other pathogenic streptococci
    Daniel Llull
    Departamento de Microbiologia Molecular, Centro de Investigaciones Biologicas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain
    Antimicrob Agents Chemother 51:1844-8. 2007
    ..5 microM. Bactericidal activity was also observed in cultures of other streptococci, although these failed to undergo lysis. The autolysis elicited by miltefosine can be attributed to triggering of the pneumococcal autolysin LytA...
  90. ncbi A phase II trial of perifosine in locally advanced, unresectable, or metastatic pancreatic adenocarcinoma
    Robert de W Marsh
    University of Florida, Department of Medicine, Division of Hematology Oncology, Gainesville, Florida 32610 0277, USA
    Am J Clin Oncol 30:26-31. 2007
    ..Perifosine, a heterocyclic alkylphosphocholine signal transduction inhibitor, has activity against multiple cell types in vitro. This is a phase II study to determine activity and toxicity of perifosine in pancreatic adenocarcinoma...
  91. ncbi Antibodies of IgM subclass to phosphorylcholine and oxidized LDL are protective factors for atherosclerosis in patients with hypertension
    Jun Su
    Center of Infectious Medicine and Unit of Rheumatology, F 59 Department of Medicine, Karolinska University Hospital, Huddinge, Stockholm 141 86, Sweden
    Atherosclerosis 188:160-6. 2006
    OBJECTIVE: To determine the importance of antibodies against phosphorylcholine (PC) and oxidized low density lipoprotein (OxLDL) for development of atherosclerosis...
  92. ncbi Noninvasive detection of lentiviral-mediated choline kinase targeting in a human breast cancer xenograft
    Balaji Krishnamachary
    Johns Hopkins University In Vivo Cellular Molecular Imaging Center Program, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 69:3464-71. 2009
    ..This study shows the use of lentiviral vectors to target chk in a human breast cancer xenograft and noninvasive MRS detection of this targeting...
  93. ncbi Novel biomimetic surfactant: synthesis and micellar characteristics
    Jian-Ping Xu
    Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, P. R. China
    Macromol Biosci 5:164-71. 2005
    ..Novel biomimetic surfactants based on cholesterol as the hydrophobic segment and poly[2-(methacryloyloxy)ethyl phosphorylcholine] (pMPC) as the hydrophilic segment were synthesized in the present study by atom transfer radical ..
  94. ncbi Synthesis and characterization of biocompatible thermo-responsive gelators based on ABA triblock copolymers
    Chengming Li
    Department of Chemistry, University of Sheffield, Brook Hill, Sheffield, South Yorkshire S3 7HF, United Kingdom
    Biomacromolecules 6:994-9. 2005
    ..outer A blocks comprise poly(N-isopropylacrylamide) and the central B block is poly(2-methacryloyloxyethyl phosphorylcholine) is achieved using atom transfer radical polymerization with a commercially available bifunctional initiator...
  95. ncbi Progress in the treatment of a neglected infectious disease: visceral leishmaniasis
    Henry W Murray
    Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Expert Rev Anti Infect Ther 2:279-92. 2004
    ....
  96. ncbi Novel biomimetic polymersomes as polymer therapeutics for drug delivery
    Jian-Ping Xu
    Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, P.R. China
    J Control Release 107:502-12. 2005
    Novel amphiphilic diblock copolymers, cholesterol-end-capped poly(2-methacryloyloxyethyl phosphorylcholine) (CMPC), which have poly(2-methacryloyloxyethyl phosphorylcholine) (poly(MPC)) as hydrophilic segment and cholesterol as ..
  97. ncbi A new class of biochemically degradable, stimulus-responsive triblock copolymer gelators
    Chengming Li
    Dainton Building, Department of Chemistry, University of Sheffield, Brook Hill, Sheffield, South Yorkshire, S3 7HF, UK
    Angew Chem Int Ed Engl 45:3510-3. 2006
  98. ncbi Cell adhesion and morphology in porous scaffold based on enantiomeric poly(lactic acid) graft-type phospholipid polymers
    Junji Watanabe
    Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8656, Japan
    Biomacromolecules 3:1375-83. 2002
    ..The cytocompatible polymer was composed of 2-methacryloyloxyethyl phosphorylcholine (MPC), n-butyl methacrylate (BMA), and the enantiomeric PLLA (or PDLA) macromonomer...
  99. ncbi Phosphorylcholine-based pH-responsive diblock copolymer micelles as drug delivery vehicles: light scattering, electron microscopy, and fluorescence experiments
    Cristiano Giacomelli
    , LCPO-ENSCPB, , 16 Av. Pey Berland, 33607 Pessac Cedex, France
    Biomacromolecules 7:817-28. 2006
    ..of a diblock copolymer comprising a highly hydrophilic and biocompatible poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) corona-forming block and a pH-sensitive poly(2-(diisopropylamino)ethyl methacrylate) (PDPA) core-..
  100. ncbi Synthesis and characterization of biocompatible, thermoresponsive ABC and ABA triblock copolymer gelators
    Chengming Li
    Department of Chemistry, Dainton Building, University of Sheffield, Brook Hill, Sheffield, South Yorkshire, S3 7HF, UK
    Langmuir 21:11026-33. 2005
    ..This is consistent with intramicelle collapse of the outer PNIPAM blocks prior to the development of the intermicelle hydrophobic interactions that are a prerequisite for macroscopic gelation...
  101. ncbi Synthesis of biocompatible, stimuli-responsive, physical gels based on ABA triblock copolymers
    Yinghua Ma
    School of Chemistry, Physics and Environmental Science, University of Sussex, Falmer, Brighton BN1 9QJ, U.K
    Biomacromolecules 4:864-8. 2003
    ..methacrylate), DPA or 2-(diethylamino)ethyl methacrylate), DEA; B = 2-methacryloyloxyethyl phosphorylcholine, MPC] prepared using atom transfer radical polymerization dissolve in acidic solution but form biocompatible ..

Research Grants85

  1. BACTERIAL PHOSPHORYLCHOLINE AND PATHOGENESIS
    Jeffrey Weiser; Fiscal Year: 2003
    ..An exception to this rule is the expression of phosphorylcholine (ChoP)...
  2. Deregulated lipid metabolism in stroke
    RAO M ADIBHATLA; Fiscal Year: 2010
    ..The long-range thrust of this research is to develop strategies to minimize disabilities due to stroke. ..
  3. Development of Chemical Receptors for Proteins
    Sanku Mallik; Fiscal Year: 2005
    ..Testing of the synthetic receptors for possible applications in detection of metastatic cancer, imaging and delivery of anti- cancer drugs. ..
  4. CDP-choline: Mechanisms in Cerebral Ischemia
    RAO ADIBHATLA; Fiscal Year: 2006
    ..Arachidonic acid activates neutral sphingomyelinase, resulting in membrane disintegration. PCCT activity was stimulated by exogenous CDP-choline. Aim 2 will be tested in gerbil transient forebrain ischemia. ..
  5. Bacterial biofilms in otitis media
    WILLIAM SWORDS; Fiscal Year: 2009
    ..influenzae biofilms contain sialic acid and phosphorylcholine that contribute to the progression of otitis in a chinchilla middle-ear infection model system...
  6. Bacterial biofilms in otitis media
    WILLIAM SWORDS; Fiscal Year: 2007
    ..influenzae biofilms contain sialic acid and phosphorylcholine that contribute to the progression of otitis in a chinchilla middle-ear infection model system...
  7. BIOACTIVITIES OF PNEUMOCOCCAL CELL WALL IN MENINGITIS
    Elaine I Tuomanen; Fiscal Year: 2011
    ..blood brain barrier (CbpA on the cell wall ligates laminin receptor LR) and then penetrates into the CNS (phosphorylcholine PCho on the cell wall ligates platelet activating factor receptor PAFr) and have shown that these steps are ..
  8. Structure-Function Relationships of C-Reactive Protein
    Alok Agrawal; Fiscal Year: 2006
    ..These studies will provide substantial insight into the mechanisms by which this ancient protein may contribute to host defense, or alternatively, to pathogenesis of disease. ..
  9. GENETICS & VIRULENCE OF PNEUMOCOCCAL CAPSULAR TYPES
    Janet Yother; Fiscal Year: 1993
    ....
  10. Genetic Control of Phospholipid Biosynthesis and Muscular Dystrophy
    Gregory Cox; Fiscal Year: 2007
    ..The rmd mouse offers the first demonstration of a defect in a phospholipid biosynthetic enzyme causing muscular dystrophy and may reveal unique entry points in which to intervene in the disease process. ..
  11. Bacterial host mimicry and chronic airway infection
    WILLIAM SWORDS; Fiscal Year: 2009
    ..that share certain structural modifications, including the addition of host structures like sialic acid and phosphorylcholine. Data included in this application show that the addition of phosphorylcholine to these endotoxins decreases ..
  12. Genetic Control of Phospholipid Biosynthesis and Muscular Dystrophy
    Gregory A Cox; Fiscal Year: 2010
    ..The rmd mouse offers the first demonstration of a defect in a phospholipid biosynthetic enzyme causing muscular dystrophy and may reveal unique entry points in which to intervene in the disease process. ..
  13. MR Based Molecular Imaging of Prostate Cancer
    John Kurhanewicz; Fiscal Year: 2009
    ....
  14. Control of lung permeability by oxidized phospholipids
    Konstantin Birukov; Fiscal Year: 2007
    ..Oxidation of a natural phospholipid component, 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (OxPAPC) reproduces a wide spectrum of physiological effects exerted by oxidized phospholipids...
  15. Competition Among Bacterial Resiratory Pathogens
    Jeffrey Weiser; Fiscal Year: 2004
    ..Both organisms express cell-surface phosphorylcholine (ChoP), an unusual bacterial structure that allows for binding to epithelial cells expressing the receptor ..
  16. C-Reactive Protein in Human Mucosal Immunity
    Jane Gould; Fiscal Year: 2005
    ..It's function in the serum includes binding to phosphorylcholine (ChoP) on the cell wall of Streptococcus pneumoniae, which leads to activation of the complement pathway and ..