nitrosamines

Summary

Summary: A class of compounds that contain a -NH2 and a -NO radical. Many members of this group have carcinogenic and mutagenic properties.

Top Publications

  1. ncbi Nicotinic receptors mediate tumorigenic action of tobacco-derived nitrosamines on immortalized oral epithelial cells
    Juan Arredondo
    Department of Dermatology, University of California at Davis, Davis, California, USA
    Cancer Biol Ther 5:511-7. 2006
  2. ncbi Determination of tobacco-specific nitrosamines in replacement liquids of electronic cigarettes by liquid chromatography-tandem mass spectrometry
    Hyun Ji Kim
    Department of Environmental Science, Kongju National University, Kongju 314 701, South Korea
    J Chromatogr A 1291:48-55. 2013
  3. ncbi HSP70 and mucin 5B: novel protein targets of N,N'-dinitrosopiperazine-induced nasopharyngeal tumorigenesis
    Fa qing Tang
    Xiangya Hospital, Department of Pathology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China
    Cancer Sci 100:216-24. 2009
  4. ncbi Surveillance of moist snuff: total nicotine, moisture, pH, un-ionized nicotine, and tobacco-specific nitrosamines
    Patricia Richter
    Office on Smoking and Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Nicotine Tob Res 10:1645-52. 2008
  5. ncbi Cytochrome P450 2A-catalyzed metabolic activation of structurally similar carcinogenic nitrosamines: N'-nitrosonornicotine enantiomers, N-nitrosopiperidine, and N-nitrosopyrrolidine
    Hansen L Wong
    University of Minnesota, The Cancer Center, 420 Delaware Street SE, Mayo Mail Code 806, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 18:61-9. 2005
  6. pmc Nitrosamines as nicotinic receptor ligands
    Hildegard M Schuller
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Life Sci 80:2274-80. 2007
  7. ncbi Beta-adrenergic modulation of NNK-induced lung carcinogenesis in hamsters
    H M Schuller
    Experimental Oncology Laboratory, College of Veterinary Medicine, University of Tennessee, Knoxville 37906, USA
    J Cancer Res Clin Oncol 126:624-30. 2000
  8. ncbi Characterization of N-glucuronidation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human liver: importance of UDP-glucuronosyltransferase 1A4
    Doris Wiener
    Cancer Epidemiology and Prevention Program, H Lee Moffitt Cancer Center, Department of Interdisciplinary Oncology, University of South Florida, Tampa, USA
    Drug Metab Dispos 32:72-9. 2004
  9. ncbi Predicting the mutagenicity of tobacco-related N-nitrosamines in humans using 11 strains of Salmonella typhimurium YG7108, each coexpressing a form of human cytochrome P450 along with NADPH-cytochrome P450 reductase
    K Fujita
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Environ Mol Mutagen 38:339-46. 2001
  10. ncbi Survival function of protein kinase C{iota} as a novel nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-activated bad kinase
    Zhaohui Jin
    University of Florida Shands Cancer Center, Department of Medicine, University of Florida, Gainesville, Florida 32610 0232, USA
    J Biol Chem 280:16045-52. 2005

Detail Information

Publications285 found, 100 shown here

  1. ncbi Nicotinic receptors mediate tumorigenic action of tobacco-derived nitrosamines on immortalized oral epithelial cells
    Juan Arredondo
    Department of Dermatology, University of California at Davis, Davis, California, USA
    Cancer Biol Ther 5:511-7. 2006
    ..Emerging evidence indicates that nAChRs can be stimulated by the nicotine-derived nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine (NNN) that can induce oral ..
  2. ncbi Determination of tobacco-specific nitrosamines in replacement liquids of electronic cigarettes by liquid chromatography-tandem mass spectrometry
    Hyun Ji Kim
    Department of Environmental Science, Kongju National University, Kongju 314 701, South Korea
    J Chromatogr A 1291:48-55. 2013
    A liquid chromatography-tandem mass spectrometric method was described to detect tobacco-specific nitrosamines (TSNAs) in replacement liquids of electronic cigarettes...
  3. ncbi HSP70 and mucin 5B: novel protein targets of N,N'-dinitrosopiperazine-induced nasopharyngeal tumorigenesis
    Fa qing Tang
    Xiangya Hospital, Department of Pathology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China
    Cancer Sci 100:216-24. 2009
    ..Our data indicate that DNP triggers over-expression of HSP70 and mucin 5B, and is involved in nasopharyngeal tumorigenesis. HSP70 and mucin 5B may be important targets in nasopharyngeal tumorigenesis induced by DNP...
  4. ncbi Surveillance of moist snuff: total nicotine, moisture, pH, un-ionized nicotine, and tobacco-specific nitrosamines
    Patricia Richter
    Office on Smoking and Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Nicotine Tob Res 10:1645-52. 2008
    ..Tobacco-specific nitrosamines (TSNAs) are potent carcinogens in smokeless tobacco products, and the pH of the product influences the content ..
  5. ncbi Cytochrome P450 2A-catalyzed metabolic activation of structurally similar carcinogenic nitrosamines: N'-nitrosonornicotine enantiomers, N-nitrosopiperidine, and N-nitrosopyrrolidine
    Hansen L Wong
    University of Minnesota, The Cancer Center, 420 Delaware Street SE, Mayo Mail Code 806, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 18:61-9. 2005
    ..These nitrosamines may be causative agents in human cancer...
  6. pmc Nitrosamines as nicotinic receptor ligands
    Hildegard M Schuller
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Life Sci 80:2274-80. 2007
    b>Nitrosamines are carcinogens formed in the mammalian organism from amine precursors contained in food, beverages, cosmetics and drugs. The potent carcinogen, NNK, and the weaker carcinogen, NNN, are nitrosamines formed from nicotine...
  7. ncbi Beta-adrenergic modulation of NNK-induced lung carcinogenesis in hamsters
    H M Schuller
    Experimental Oncology Laboratory, College of Veterinary Medicine, University of Tennessee, Knoxville 37906, USA
    J Cancer Res Clin Oncol 126:624-30. 2000
    ..We have recently shown that the growth of cell lines derived from human PACs is controlled by beta-adrenergic receptors, and that NNK is a high affinity agonist for this receptor family...
  8. ncbi Characterization of N-glucuronidation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human liver: importance of UDP-glucuronosyltransferase 1A4
    Doris Wiener
    Cancer Epidemiology and Prevention Program, H Lee Moffitt Cancer Center, Department of Interdisciplinary Oncology, University of South Florida, Tampa, USA
    Drug Metab Dispos 32:72-9. 2004
    ..These results demonstrate the importance of N-glucuronidation in the metabolism of NNAL and the role of UGT1A4 in this pathway...
  9. ncbi Predicting the mutagenicity of tobacco-related N-nitrosamines in humans using 11 strains of Salmonella typhimurium YG7108, each coexpressing a form of human cytochrome P450 along with NADPH-cytochrome P450 reductase
    K Fujita
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Environ Mol Mutagen 38:339-46. 2001
    Tobacco, including snuff and chewing tobacco, contains N-nitrosamines such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), N-nitrosodiethylamine (NDEA), N-nitrosopyrrolidine (NPYR), N-nitrosopiperidine (NPIP), N-nitrosomorpholine ..
  10. ncbi Survival function of protein kinase C{iota} as a novel nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-activated bad kinase
    Zhaohui Jin
    University of Florida Shands Cancer Center, Department of Medicine, University of Florida, Gainesville, Florida 32610 0232, USA
    J Biol Chem 280:16045-52. 2005
    ....
  11. ncbi 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone from cigarette smoke stimulates colon cancer growth via beta-adrenoceptors
    William K K Wu
    Department of Pharmacology, Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Cancer Res 65:5272-7. 2005
    ..These findings partly elucidate the carcinogenic actions of cigarette smoke and shed new light on the novel modulatory role of beta-adrenoceptors in the development of colon cancer...
  12. ncbi Evidence for the epidermal growth factor receptor as a target for lung cancer prevention
    Fulvio Lonardo
    Harper Hospital, Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Clin Cancer Res 8:54-60. 2002
    ..RA effects on epidermal growth factor (EGF) induction of EGFR-phosphotyrosine levels, cyclin D1 expression and mitogenesis were examined in BEAS-2B cells...
  13. ncbi Post-initiation chemopreventive effects of dietary bovine lactoferrin on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in female A/J mice
    Yoko Matsuda
    Department of Pathology and Host Defense, Faculty of Medicine, Onco Pathology, Kagawa University, 1750 1 Ikenobe, Kida gun, Kagawa, Japan
    Cancer Lett 246:41-6. 2007
    ..bLF might inhibit NNK-induced mouse lung tumorigenesis, only when given limited to the post-initiation phase, through modification of cell proliferation and/or apoptosis...
  14. ncbi Concomitant presence of N-nitroso and S-nitroso proteins in human plasma
    Tienush Rassaf
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Free Radic Biol Med 33:1590-6. 2002
    ..Our findings may not only have important implications for the transport of NO in vivo, but also for cardiovascular disease diagnostics and the risk assessment of nitrosamine-related carcinogenesis in man...
  15. ncbi Metabolites of a tobacco-specific lung carcinogen in nonsmoking women exposed to environmental tobacco smoke
    K E Anderson
    Division of Epidemiology, University of Minnesota, Minneapolis 55454, USA
    J Natl Cancer Inst 93:378-81. 2001
    ..We measured metabolites of a tobacco-specific lung carcinogen in urine from healthy, nonsmoking women exposed to ETS...
  16. ncbi Mutagenic activation of betel quid-specific N-nitrosamines catalyzed by human cytochrome P450 coexpressed with NADPH-cytochrome P450 reductase in Salmonella typhimurium YG7108
    Masafumi Miyazaki
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, N12W6, Kita ku, Sapporo 060 0812, Japan
    Mutat Res 581:165-71. 2005
    ..Areca nut contained in the betel quid is believed to give rise to carcinogenic N-nitrosamines. In the present study, the roles of human cytochromes P450 (P450 or CYP) in the mutagenic activation of betel ..
  17. ncbi Decreased levels of tobacco-specific N-nitrosamines in moist snuff on the Swedish market
    Bengt Göran Osterdahl
    Swedish National Food Administration, Box 622, SE 751 26 Uppsala, Sweden
    J Agric Food Chem 52:5085-8. 2004
    Moist snuff, or snus, on the Swedish market in 2001 and 2002 was analyzed for tobacco-specific N-nitrosamines (TSNAs) using a recently developed LC-MS/MS method...
  18. ncbi A study to estimate and correlate cigarette smoke exposure in smokers in Germany as determined by filter analysis and biomarkers of exposure
    Christopher J Shepperd
    British American Tobacco, Group Research and Development, Regents Park Road, Millbrook, Southampton, Hampshire SO15 8TL, UK
    Regul Toxicol Pharmacol 55:97-109. 2009
    ....
  19. ncbi The tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone stimulates proliferation of immortalized human pancreatic duct epithelia through beta-adrenergic transactivation of EGF receptors
    Minoo D F Askari
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, 37996, USA
    J Cancer Res Clin Oncol 131:639-48. 2005
    ..The goal of this study was to elucidate the NNK effects on the signal transduction pathways downstream of both beta(1)- and beta(2)-adrenergic receptors in immortalized human pancreatic HPDE6-c7 cells...
  20. ncbi Mechanisms of smoking-related lung and pancreatic adenocarcinoma development
    Hildegard M Schuller
    Department of Pathology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, Tennessee 37996, USA
    Nat Rev Cancer 2:455-63. 2002
  21. ncbi Cell type specific, receptor-mediated modulation of growth kinetics in human lung cancer cell lines by nicotine and tobacco-related nitrosamines
    H M Schuller
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville 37901 1071
    Biochem Pharmacol 38:3439-42. 1989
    ..receptors in the mediation of cell type specific biological effects of nicotine and the two tobacco-related nitrosamines N-nitrosodiethylamine (DEN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) on human lung cells...
  22. ncbi Effect of differing levels of tobacco-specific nitrosamines in cigarette smoke on the levels of biomarkers in smokers
    David L Ashley
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Cancer Epidemiol Biomarkers Prev 19:1389-98. 2010
    Smokers are exposed to significant doses of carcinogens, including tobacco-specific nitrosamines (TSNA)...
  23. pmc Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells
    Kip A West
    Cancer Therapeutics Branch, Cell and Cancer Biology Branch, National Cancer Institute, Bethesda, Maryland 20889, USA
    J Clin Invest 111:81-90. 2003
    ..Redundant Akt activation by nicotine and NNK could contribute to tobacco-related carcinogenesis by regulating two processes critical for tumorigenesis, cell growth and apoptosis...
  24. ncbi Global surveillance of oral tobacco products: total nicotine, unionised nicotine and tobacco-specific N-nitrosamines
    Stephen B Stanfill
    Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, Emergency Response and Air Toxicants Branch, 4770 Buford Highway, Atlanta, Georgia 30341, USA
    Tob Control 20:e2. 2011
    Oral tobacco products contain nicotine and carcinogenic tobacco-specific N-nitrosamines (TSNAs) that can be absorbed through the oral mucosa...
  25. ncbi Opisthorchis viverrini infestation and endogenous nitrosamines as risk factors for cholangiocarcinoma in Thailand
    P Srivatanakul
    National Cancer Institute of Thailand, Bangkok
    Int J Cancer 48:821-5. 1991
    ..Small amounts of pre-formed nitrosamines were found in fermented fish and pork food items, which are consumed frequently in the high-risk area for CCA...
  26. ncbi Dietary polyphenols protect against N-nitrosamines and benzo(a)pyrene-induced DNA damage (strand breaks and oxidized purines/pyrimidines) in HepG2 human hepatoma cells
    Maria Eugenia Delgado
    Depto de Nutrición, Facultad de Veterinaria, Universidad Complutense de Madrid, Madrid, Spain
    Eur J Nutr 47:479-90. 2008
    ..Dietary polyphenols have been reported to have a variety of biological actions, including anticarcinogenic and antioxidant activities...
  27. ncbi Occurrence and source of nitrosamines and secondary amines in groundwater and its adjacent Jialu River basin, China
    Fujun Ma
    Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China
    Environ Sci Technol 46:3236-43. 2012
    The presence of mutagenic and carcinogenic nitrosamines in groundwater is of great concern...
  28. ncbi Study of the metabolism on tobacco-specific N-nitrosamines in the rabbit by solid-phase extraction and liquid chromatography-tandem mass spectrometry
    Chenchen Li
    Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, People s Republic of China
    Anal Bioanal Chem 386:1985-93. 2006
    Metabolism of four tobacco-specific N-nitrosamines (TSNAs), N'-nitrosonornicotine (NNN), N'-nitrosoanatabine (NAT), N'-nitrosoanabasine (NAB), and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) has been studied by solid-phase ..
  29. pmc Tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone initiates and enhances pancreatitis responses
    M Alexandre
    Department of Internal Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol Gastrointest Liver Physiol 303:G696-704. 2012
    ..These studies suggest that prolonged exposure to this tobacco toxin can cause pancreatitis and sensitize to disease. Therapies targeting NNK-mediated pathways may prove useful in treatment of smoking-related pancreatitis...
  30. pmc Maternal dietary intake of nitrates, nitrites and nitrosamines and selected birth defects in offspring: a case-control study
    John C Huber
    Department of Epidemiology and Biostatistics, The Texas A and M Health Science Center School of Rural Public Health, MS 1266 TAMU, College Station, TX 77843 1266, USA
    Nutr J 12:34. 2013
    Dietary intake of nitrates, nitrites, and nitrosamines can increase the endogenous formation of N-nitroso compounds in the stomach. Results from animal studies suggest that these compounds might be teratogenic...
  31. ncbi Myricetin, quercetin, (+)-catechin and (-)-epicatechin protect against N-nitrosamines-induced DNA damage in human hepatoma cells
    M E Delgado
    Departamento de Nutricion, Bromatologia y Tecnologia de los Alimentos, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040 Madrid, Spain
    Toxicol In Vitro 23:1292-7. 2009
    ..However, myricetin at the concentrations tested only protects human cells against oxidative DNA damage induced by NDBA and quercetin against oxidative DNA damage induced by NPIP...
  32. ncbi Determination of N-nitrosamines and nicotine in air particulate matter samples by pressurised liquid extraction and gas chromatography-ion trap tandem mass spectrometry
    M Aragon
    Department of Analytical Chemistry and Organic Chemistry, Universitat Rovira i Virgili, Marcel li Domingo s n, Sescelades Campus, Tarragona 43007, Spain
    Talanta 115:896-901. 2013
    N-nitrosamines are potentially hazardous pollutants, classified as probable carcinogenic and mutagenic by the U.S. Environmental Protection Agency (EPA)...
  33. pmc Glucuronidation of tobacco-specific nitrosamines by UGT2B10
    Gang Chen
    Penn State Cancer Institute, Hershey, PA 17033, USA
    Drug Metab Dispos 36:824-30. 2008
    ..These data suggest that UGT2B10 is likely the most active UGT isoform in human liver for the N-glucuronidation of TSNAs...
  34. ncbi Role of human cytochrome P450 (CYP) in the metabolic activation of nitrosamine derivatives: application of genetically engineered Salmonella expressing human CYP
    Tetsuya Kamataki
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Drug Metab Rev 34:667-76. 2002
    The role of human cytochrome P450 (CYP) in the metabolic activation of tobacco-related N-nitrosamines was examined by Salmonella mutation test using a series of genetically engineered Salmonella typhimurium YG7108 strains each co-..
  35. ncbi Lack of promoting effects from physical pulmonary collapse in a female A/J mouse lung tumor initiated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) with remarkable mesothelial cell reactions in the thoracic cavity by the polymer
    Masanao Yokohira
    Onco Pathology, Department of Pathology and Host Defence, Faculty of Medicine, Kagawa University, 1750 1, Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Exp Toxicol Pathol 63:181-5. 2011
    ..It remains possible, however, that alternative approaches might have greater efficacy and these need more consideration. In addition, mesothelial cells reaction was observed with the infused polymer...
  36. ncbi 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone is correlated with 8-hydroxy-2'-deoxyguanosine in humans after exposure to environmental tobacco smoke
    Hung Che Chiang
    Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Zhunan, Miaoli County, Taiwan, ROC
    Sci Total Environ 414:134-9. 2012
    ..Furthermore, this correlation supports the hypothesis that oxidative DNA damage is one of major adverse effects induced by ETS exposure in humans...
  37. pmc Carcinogenic tobacco-specific N-nitrosamines in US cigarettes: three decades of remarkable neglect by the tobacco industry
    Irina Stepanov
    Masonic Cancer Center and Tobacco Use Research Programs, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Tob Control 21:44-8. 2012
    ..other changes in cigarette manufacturing techniques could substantially reduce the levels of tobacco-specific nitrosamines (TSNA), a group of potent carcinogens, in cigarette smoke...
  38. ncbi Determination of tobacco-specific N-nitrosamines in urine of smokers and non-smokers
    Dominique Kavvadias
    Analytisch Biologisches Forschungslabor GmbH, Munich, Germany
    Biomarkers 14:547-53. 2009
    Tobacco-specific N-nitrosamines (TSNA) include 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), N'-nitrosonornicotine (NNN), N'-nitrosoanabasine (NAB) and N'-nitrosoanatabine (NAT) and are found in tobacco and tobacco smoke...
  39. ncbi Addition of porphyrins to cigarette filters to reduce the levels of benzo[a]pyrene (B[a]P) and tobacco-specific N-nitrosamines (TSNAs) in mainstream cigarette smoke
    Changguo Wang
    Sichuan Key Laboratory Technical Research Center, Chuanyu Branch of China Tobacco Corporation, Chengdu 610066, People s Republic of China
    J Agric Food Chem 59:7172-7. 2011
    Tobacco-specific N-nitrosamines (TSNAs) and benzo[a]pyrene (B[a]P) in mainstream cigarette smoke (MSS) cause smoking-related diseases and environmental pollution...
  40. pmc Subpicogram per milliliter determination of the tobacco-specific carcinogen metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human urine using liquid chromatography-tandem mass spectrometry
    Peyton Jacob
    Division of Clinical Pharmacology, University of California, San Francisco, UCSF Box 1220, San Francisco, California 94143 1220, USA
    Anal Chem 80:8115-21. 2008
    ..The lower limit of quantitation is 0.25 pg/mL for 5-mL urine specimens. Applications to studies of people with a range of different SHS exposure levels is described...
  41. ncbi Mechanisms of chemopreventive effects of 8-methoxypsoralen against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung adenomas
    Masafumi Miyazaki
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    Carcinogenesis 26:1947-55. 2005
    ..Based on these lines of evidence, we propose that 8-methoxypsoralen inhibits the CYP2A5-mediated metabolic activation of NNK in the mouse lung, leading to the prevention of NNK-induced adenoma...
  42. ncbi Humoral immunity: polycyclic aromatic hydrocarbons and nitrosamines
    I V Zhigacheva
    Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Vorob evskoe sh 2b, Moscow, 117977 Russia
    Dokl Biol Sci 383:120-2. 2002
  43. ncbi Stability of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in urine samples stored at various temperatures
    Yang Xia
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, Atlanta, Georgia 30341, USA
    J Anal Toxicol 34:411-5. 2010
    ..These results suggest that valid NNAL concentrations can be measured in frozen urine samples that have been stored for an extended period of time prior to analysis...
  44. ncbi [Profile of telomerase and telomerase RNA expression in nasopharyngeal carcinogenesis of rats induced by N, N'dinitrosopiperazine (DNP)]
    F Tang
    Xiangya Hospital, Hunan Medical University, Changsha 410078, China
    Zhonghua Bing Li Xue Za Zhi 30:125-8. 2001
    ..To investigate the profile of telomerase and telomerase RNA expression in nasopharyngeal carcinogenesis (NPC) induced by N, N'dinitrosopiperazine (DNP) and examined histolofically...
  45. ncbi Intragastric volatile N-nitrosamines, nitrite, pH, and Helicobacter pylori during long-term treatment with omeprazole
    I T Vermeer
    Department of Health Risk Analysis and Toxicology, Maastricht University, Maastricht, The Netherlands
    Gastroenterology 121:517-25. 2001
    This study evaluated the effect of long-term gastric acid suppressive therapy with omeprazole on intragastric levels of carcinogenic N-nitrosamines and related parameters.
  46. pmc Maternal characteristics associated with the dietary intake of nitrates, nitrites, and nitrosamines in women of child-bearing age: a cross-sectional study
    John S Griesenbeck
    Department of Epidemiology and Biostatistics, School of Rural Public Health, Texas A and M Health Science Center, College Station, TX, 77843 1266, USA
    Environ Health 9:10. 2010
    ..Very little information is available on intake of nitrates, nitrites, and nitrosamines and factors related to increased consumption of these compounds.
  47. ncbi Effects of antibodies induced by a conjugate vaccine on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone absorptive transport, metabolism, and proliferation of human lung cells
    Stefan S De Buck
    Institute of Immunology, LNS CRP Santé, Luxembourg, Grand Duchy of Luxembourg
    Int J Cancer 127:513-20. 2010
    ..These in vitro data therefore suggest that a prophylactic antibody response may be associated with a reduced risk of cancer...
  48. pmc N,N'-dinitrosopiperazine-mediated ezrin protein phosphorylation via activation of Rho kinase and protein kinase C is involved in metastasis of nasopharyngeal carcinoma 6-10B cells
    Faqing Tang
    Medical Research Center, Zhuhai Hospital, Guangzhou 510000, Guangdong, China
    J Biol Chem 286:36956-67. 2011
    ..DNP may be involved in NPC metastasis through regulation of ezrin phosphorylation at Thr-567...
  49. pmc Enhancive effect of N,N'-dinitrosopiperazine on inducing precancerous lesion on nasal and/or nasopharyngeal epithelia of TgN(p53mt-LMP1)/HT mice
    Dao fa Tian
    Faculty of Integrative Medicine, Chinese Medicine University of Hunan, and Department of Clinical Laboratory, the First Xiangya Hospital, Changsha 410007, China
    J Zhejiang Univ Sci B 10:172-9. 2009
    ....
  50. ncbi Inhibition of adenoma progression to adenocarcinoma in a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis model in A/J mice by tea polyphenols and caffeine
    Gang Lu
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 16445 0687, USA
    Cancer Res 66:11494-501. 2006
    ..This effect is closely associated with decreased cell proliferation, enhanced apoptosis, and lowered levels of c-Jun and Erk1/2 phosphorylation...
  51. pmc Nitrosamine and related food intake and gastric and oesophageal cancer risk: a systematic review of the epidemiological evidence
    Paula Jakszyn
    Unit of Nutrition, Environment and Cancer, Department of Epidemiology and Cancer Registry, Institut Catala d Oncologia, ICO IDIBELL, L Hospitalet de LLobregrat 08907, Barcelona, Spain
    World J Gastroenterol 12:4296-303. 2006
    ..To study the association between nitrite and nitrosamine intake and gastric cancer (GC), between meat and processed meat intake, GC and oesophageal cancer (OC), and between preserved fish, vegetable and smoked food intake and GC...
  52. ncbi The molecular basis for induction of human cancers by tobacco specific nitrosamines
    Robert Nilsson
    Department of Genetics, Microbiology and Toxicology, Stockholm University, Svante Arrhenius väg 16E, Frescati, S 106 91 Stockholm, Sweden
    Regul Toxicol Pharmacol 60:268-80. 2011
    ..For carcinogenic oral snuffs with extremely high concentrations of tobacco specific nitrosamines (TSNA) the DNA adduct levels predicted from animal experiments exceed those found in "unexposed" individuals...
  53. pmc Urine cotinine underestimates exposure to the tobacco-derived lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in passive compared with active smokers
    Neal Benowitz
    Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 1220, USA
    Cancer Epidemiol Biomarkers Prev 19:2795-800. 2010
    ....
  54. ncbi Combination experiments with very low doses of three genotoxic N-nitrosamines with similar organotropic carcinogenicity in rats
    M R Berger
    Institute of Toxicology and Chemotherapy, German Cancer Research Center, Heidelberg, FRG
    Carcinogenesis 8:1635-43. 1987
    ..The N-nitrosamines were administered throughout the rats' lives individually and in combination at three logarithmically spaced ..
  55. ncbi Red meat, dietary nitrosamines, and heme iron and risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Paula Jakszyn
    Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, AV gran via 199 08907, L Hospitalet de Llobregat, Barcelona, Spain
    Cancer Epidemiol Biomarkers Prev 20:555-9. 2011
    Previous epidemiologic studies found inconsistent results for the association between red meat intake, nitrosamines [NDMA: N-nitrosodimethylamine, and ENOC (endogenous nitroso compounds)], and the risk of bladder cancer...
  56. pmc Elimination kinetics of the tobacco-specific biomarker and lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol
    Maciej L Goniewicz
    Department of Medicine, University of California, San Francisco, USA
    Cancer Epidemiol Biomarkers Prev 18:3421-5. 2009
    ....
  57. ncbi N-nitrosamines are associated with shorter telomere length
    Huiqi Li
    Section of Occupational and Environmental Medicine, Lund University Hospital, SE 221 85 Lund, Sweden
    Scand J Work Environ Health 37:316-24. 2011
    ..Aiming to examine the relationship between DNA-damaging agents and average telomere length in peripheral blood, we conducted a cross-sectional study among 157 workers working in the rubber industry in Sweden...
  58. ncbi Tobacco-specific nitrosamines in tobacco from U.S. brand and non-U.S. brand cigarettes
    David L Ashley
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Nicotine Tob Res 5:323-31. 2003
    Tobacco-specific nitrosamines (TSNAs) are one of the major classes of carcinogens found in tobacco products. As part of collaborative efforts to reduce tobacco use and resulting disease, the U.S...
  59. pmc Comparative functional genomics analysis of NNK tobacco-carcinogen induced lung adenocarcinoma development in Gprc5a-knockout mice
    Junya Fujimoto
    Department of Thoracic Head and Neck Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 5:e11847. 2010
    ..Previously, we found that mice with a knockout (KO) of G-protein coupled receptor 5A (Gprc5a) develop lung tumors after a long latent period (12 to 24 months)...
  60. ncbi Tobacco-specific nitrosamines in smokeless tobacco products marketed in India
    Irina Stepanov
    The Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Int J Cancer 116:16-9. 2005
    Smokeless tobacco products are a known cause of oral cancer in India. Carcinogenic tobacco-specific nitrosamines in these products are believed to be at least partially responsible for cancer induction, but there have been no recent ..
  61. ncbi Levels of tobacco-specific nitrosamines and polycyclic aromatic hydrocarbons in mainstream smoke from different tobacco varieties
    Yan S Ding
    Emergency Response and Air Toxicants Branch, Division of Laboratory Science, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway Northeast, Mailstop F 47, Atlanta, GA 30341 3724, USA
    Cancer Epidemiol Biomarkers Prev 17:3366-71. 2008
    ..According to the IARC, 10 polycyclic aromatic hydrocarbons (PAH) and 8 tobacco-specific nitrosamines (TSNA), as well as at least 45 other compounds or substances found in tobacco smoke, are potential human ..
  62. ncbi Migration of nitrosamines from rubber products--are balloons and condoms harmful to the human health?
    Werner Altkofer
    Chemisches und Veterinaeruntersuchungsamt Stuttgart, Fellbach, Germany
    Mol Nutr Food Res 49:235-8. 2005
    Studies performed in 2001 and 2003 surveyed the release of carcinogenic nitrosamines and nitrosatable substances from rubber toy balloons by extraction with artificial saliva and gas chromatography-thermal energy analysis (GC-TEA)...
  63. ncbi Inhibitory effect of diet related sulphydryl compounds on the formation of carcinogenic nitrosamines
    N R Shenoy
    Bio Organic Division, Bhabha Atomic Research Centre, Trombay, Bombay, India
    Cancer Lett 65:227-32. 1992
    ..Toxicol., 25 (1987) 91-108). Several factors present in the diet can modify levels of endogenously formed nitrosamines by acting as catalysts or inhibitors...
  64. ncbi Understanding tobacco smoke carcinogen NNK and lung tumorigenesis
    Gohar Akopyan
    Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095 1747, USA
    Int J Oncol 29:745-52. 2006
    ..As such, it displays a fuller, more comprehensive overview, bringing us one step closer to understanding the fatal consequences of NNK, thus, discovering new avenues that successfully break the cycle of NNK-mediated lung carcinogenesis...
  65. ncbi The nicotinic receptor antagonists abolish pathobiologic effects of tobacco-derived nitrosamines on BEP2D cells
    Juan Arredondo
    Department of Dermatology, University of California, Davis, 3301 C Street, Suite 1400, Sacramento, CA 95816, USA
    J Cancer Res Clin Oncol 132:653-63. 2006
    ..b>Nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine (NNN) can induce tumors both ..
  66. ncbi Pretreatment with 8-methoxypsoralen, a potent human CYP2A6 inhibitor, strongly inhibits lung tumorigenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice
    Hijiri Takeuchi
    Onco Pathology, Department of Pathology and Host Defense, Kagawa Medical University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Cancer Res 63:7581-3. 2003
    ..97 to 0.23 (50 mg/kg) and 0.25 (12.5 mg/kg) tumors/mouse. These results clearly demonstrated that methoxsalen, a potent human CYP2A6 inhibitor, is a strong chemopreventive agent against NNK-induction of lung tumorigenesis...
  67. ncbi Smoking reduction and tobacco-related cancers: the more things change, the more they stay the same
    Scott J Leischow
    J Natl Cancer Inst 96:86-7. 2004
  68. ncbi Dose dependent inhibitory effects of dietary 8-methoxypsoralen on NNK-induced lung tumorigenesis in female A/J mice
    Hijiri Takeuchi
    Onco Pathology, Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Cancer Lett 234:232-8. 2006
    ....
  69. ncbi Metabolites of a tobacco-specific lung carcinogen in nonsmoking casino patrons
    Kristin E Anderson
    Division of Epidemiology, Comprehensive Cancer Center, University of Minnesota, Minneapolis, Minnesota 55454, USA
    Cancer Epidemiol Biomarkers Prev 12:1544-6. 2003
    ..044 nmol/mg creatinine, P < 0.0001) and total NNAL (0.018 pmol/mg creatinine, P < 0.001). These findings demonstrate that exposure of nonsmokers to ETS in a commercial setting results in uptake of a tobacco-specific lung carcinogen...
  70. ncbi Nongenomic beta estrogen receptors enhance beta1 adrenergic signaling induced by the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human small airway epithelial cells
    Mourad Majidi
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Cancer Res 67:6863-71. 2007
    ..This novel cooperation between beta1AR and ERbeta signaling may contribute to the prominence of lung adenocarcinoma in women...
  71. ncbi Comparative metabolism of the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol by rat cytochrome P450 2A3 and human cytochrome P450 2A13
    John R Jalas
    Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA
    Drug Metab Dispos 31:1199-202. 2003
    ....
  72. ncbi Smokeless tobacco and oral cancer: a review of the risks and determinants
    Brad Rodu
    Department of Pathology, School of Medicine, LHRB 156, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    Crit Rev Oral Biol Med 15:252-63. 2004
    ..to this association, including epidemiologic studies, studies of putative carcinogens such as tobacco-specific nitrosamines (TSNAs) and other contaminants, and possible cancer inhibitors...
  73. ncbi Characterization and mapping of DNA damage induced by reactive metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) at nucleotide resolution in human genomic DNA
    J F Cloutier
    Laboratory of Cancer Etiology and Chemoprevention, Faculty of Pharmacy, Laval University, Quebec City, G1K 7P4, Canada
    J Mol Biol 313:539-57. 2001
    ..These results represent the first step in determining if NNK pyridyloxobutylates DNA with sequence specificity similar to those observed with other model compounds...
  74. ncbi NNK-induced hamster lung adenocarcinomas over-express beta2-adrenergic and EGFR signaling pathways
    Hildegard M Schuller
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Lung Cancer 49:35-45. 2005
    ..Taken together, these data point to PKA/CREB as novel targets for the development of cancer therapeutics for PAC patients non-responsive to EGFR-specific tyrosine kinase inhibitors...
  75. ncbi Tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces cell proliferation in normal human bronchial epithelial cells through NFkappaB activation and cyclin D1 up-regulation
    Yuan Soon Ho
    Graduate Institute of Biomedical Technology, Taipei Medical University, Taipei, Taiwan
    Toxicol Appl Pharmacol 205:133-48. 2005
    ..In summary, our findings demonstrate for the first time that NNK could stimulate normal human bronchial cell proliferation through activation of the NFkappaB, which in turn up-regulated the cyclin D1 expression...
  76. ncbi Processed meat consumption, dietary nitrosamines and stomach cancer risk in a cohort of Swedish women
    Susanna C Larsson
    Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 119:915-9. 2006
    ..b>Nitrosamines may be responsible for this association, but few studies have directly examined nitrosamine intake in relation ..
  77. ncbi Detecting N-nitrosamines in drinking water at nanogram per liter levels using ammonia positive chemical ionization
    Jeffrey W A Charrois
    Department of Public Health Sciences, University of Alberta, 10 102 Clinical Sciences Building, Edmonton, Alberta, Canada T6G 2G3
    Environ Sci Technol 38:4835-41. 2004
    Detection of N-nitrosamines in water supplies is an environmental and public health issue because many N-nitrosamines are classified as probable human carcinogens...
  78. ncbi Tobacco-specific nitrosamines in new tobacco products
    Irina Stepanov
    The Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Nicotine Tob Res 8:309-13. 2006
    ..Tobacco-specific nitrosamines (TSNAs) are an important class of carcinogens in tobacco products, but virtually no data were available on ..
  79. ncbi Identification of adducts formed by pyridyloxobutylation of deoxyguanosine and DNA by 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone, a chemically activated form of tobacco specific carcinogens
    Mingyao Wang
    University of Minnesota Cancer Center, 420 Delaware Street SE, Mayo Mail Code 806, Minneapolis 55455, USA
    Chem Res Toxicol 16:616-26. 2003
    ..Adducts 23, 25, and 10 did not release HPB upon neutral thermal hydrolysis. The results of this study provide the first structural identification of an HPB-releasing DNA adduct of the tobacco specific nitrosamines NNK and NNN.
  80. ncbi Identification of O2-substituted pyrimidine adducts formed in reactions of 4-(acetoxymethylnitrosamino)- 1-(3-pyridyl)-1-butanone and 4-(acetoxymethylnitros- amino)-1-(3-pyridyl)-1-butanol with DNA
    Stephen S Hecht
    University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 17:588-97. 2004
    ..Furthermore, 26 was identified as a major 4-HPB releasing adduct of NNKCH(2)OAc. These results suggest that pyrimidine adducts of tobacco specific nitrosamines may be important contributors to their mutagenic and carcinogenic activity.
  81. pmc Cellular targets and mechanisms of nitros(yl)ation: an insight into their nature and kinetics in vivo
    Nathan S Bryan
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Proc Natl Acad Sci U S A 101:4308-13. 2004
    ..The findings also raise the intriguing possibility that N-nitrosation is directly involved in the modulation of protein function...
  82. ncbi Characterization of new nitrosamines in drinking water using liquid chromatography tandem mass spectrometry
    Yuan Yuan Zhao
    Environmental Health Sciences, School of Public Health and Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, 10 102 Clinical Sciences Building, Edmonton, Alberta, Canada T6G 2G3
    Environ Sci Technol 40:7636-41. 2006
    ..To comprehensively investigate the occurrence of possible nitrosamines in drinking water supplies, a liquid chromatography-tandem mass spectrometry technique was developed to detect ..
  83. pmc Formation and accumulation of pyridyloxobutyl DNA adducts in F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol
    Yanbin Lao
    Department of Medicinal Chemistry, and the Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 20:235-45. 2007
    ....
  84. pmc Strain-specific spontaneous and NNK-mediated tumorigenesis in Pten+/- mice
    Mary Christine Hollander
    Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20889, USA
    Neoplasia 10:866-72. 2008
    ....
  85. ncbi Increased expression of cyclooxygenase-2 in rat lung tumors induced by the tobacco-specific nitrosamine 4-(methylnitrosamino)-4-(3-pyridyl)-1-butanone: the impact of a high-fat diet
    K El-Bayoumy
    American Health Foundation, Valhalla, New York 10595, USA
    Cancer Res 59:1400-3. 1999
    ..This well-defined animal model is valuable for studying modulation of COX-2 expression in lung carcinogenesis by various factors, including dietary components...
  86. ncbi Smokeless tobacco and tobacco-related nitrosamines
    Vincent Cogliano
    WHO International Agency for Research on Cancer
    Lancet Oncol 5:708. 2004
  87. ncbi Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines
    Gang Chen
    Cancer Prevention and Control Program, Penn State Cancer Institute, Department of Public Health Sciences, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Pharmacogenet Genomics 18:181-91. 2008
    ....
  88. ncbi NNK activates ERK1/2 and CREB/ATF-1 via beta-1-AR and EGFR signaling in human lung adenocarcinoma and small airway epithelial cells
    E Laag
    Experimental Oncology Laboratory, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Int J Cancer 119:1547-52. 2006
    ..Collectively, our data provide evidence, for the first time, that NNK targets ERK1/2 and CREB/ATF-1 proteins via dual signaling involving beta 1-AR and EGFR pathways in PACCs and their putative cells of origin...
  89. ncbi Modification by curcumin of mutagenic activation of carcinogenic N-nitrosamines by extrahepatic cytochromes P-450 2B1 and 2E1 in rats
    Yukio Mori
    Institute of Biological Pharmacy, Gifu Pharmaceutical University, 6 1, Mitahora higashi 5 chome, Gifu 502 8585, Japan
    Cancer Sci 97:896-904. 2006
    ..Further, the present findings suggest the potential of curcumin for modification of gastric and intestinal carcinogenesis initiated with NOC...
  90. ncbi N(1)-acetyl-5-methoxykynuramine contrasts with other tryptophan metabolites by a peculiar type of NO scavenging: cyclization to a cinnolinone prevents formation of unstable nitrosamines
    R Hardeland
    J Pineal Res 43:104-5. 2007
  91. ncbi Development of a food database of nitrosamines, heterocyclic amines, and polycyclic aromatic hydrocarbons
    Paula Jakszyn
    Catalan Institute of Oncology, L Hospitalet de Llobregat, Barcelona, Spain
    J Nutr 134:2011-4. 2004
    ..Our objective was to develop a food composition database of nitrates, nitrites, nitrosamines, HA, and PAH...
  92. ncbi Dependence of N-nitrosodimethylamine photodecomposition on the irradiation wavelength: excitation to the s(2) state as a doorway to the dimethylamine radical ground-state chemistry
    Daniel Pelaez
    Department of Physical Chemistry, Faculty of Sciences, University of Malaga, E 29071 Malaga, Spain
    J Org Chem 72:4741-9. 2007
    ....
  93. ncbi Molecular modeling of nitrosamines adsorbed on H-ZSM-5 zeolite: an ONIOM study
    Anawat Pinisakul
    Department of Chemistry, Faculty of Science, King Mongkut s University of Technology Thonburi, 126 Pracha utis Rd, Thung kru, Bangkok 10140, Thailand
    J Mol Model 14:1035-41. 2008
    ..Based on amino and imino isomers of nitrosamines, there are two adsorption configurations on the H-ZSM-5 for NA (as NA_a and NA_i), NMA (as NMA_a and NMA_i) and ..
  94. ncbi Formation of N-nitrosamines from eleven disinfection treatments of seven different surface waters
    Yuan Yuan Zhao
    Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, 10 102 Clinical Sciences Building, University of Alberta, Edmonton, Alberta, Canada T6G 2G3
    Environ Sci Technol 42:4857-62. 2008
    Formation of nine N-nitrosamines has been investigated when seven different source waters representing various qualities were each treated with eleven bench-scale disinfection processes, without addition of nitrosamine precursors...
  95. ncbi Rapid and sensitive gas chromatography-ion-trap tandem mass spectrometry method for the determination of tobacco-specific N-nitrosamines in secondhand smoke
    Mohamad Sleiman
    Indoor Environment Department, Environmental Energy Technologies Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 70 108B, Berkeley, CA 94720, USA
    J Chromatogr A 1216:7899-905. 2009
    Tobacco-specific nitrosamines (TSNAs) are some of the most potent carcinogens in tobacco and cigarette smoke. Accurate quantification of these chemicals is needed to help assess public health risks...
  96. ncbi Urinary tobacco-specific nitrosamines and 4-aminobiphenyl hemoglobin adducts measured in smokers of either regular or light cigarettes
    John T Bernert
    Division of Laboratory Science, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Nicotine Tob Res 7:729-38. 2005
    ..Thus the concentrations of the carcinogen biomarkers NNAL and 4-ABP in the smokers who regularly smoked light cigarettes were essentially the same as those in the smokers who chose regular cigarettes...
  97. ncbi A review: dietary and endogenously formed N-nitroso compounds and risk of childhood brain tumors
    Marion Dietrich
    School of Public Health, University of California Berkeley, Berkeley, CA 94720 7360, USA
    Cancer Causes Control 16:619-35. 2005
    ..NOC consist of two main groups, N-nitrosamines and N-nitrosamides...
  98. pmc Dose-dependent inhibition of tobacco smoke carcinogen-induced lung tumorigenesis in A/J mice by indole-3-carbinol
    Fekadu Kassie
    Masonic Cancer Center, University of Minnesota, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Cancer Prev Res (Phila) 1:568-76. 2008
    ....
  99. ncbi Rabbit liver microsomal system: study of interaction with two model N-nitrosamines and their metabolism
    M Sulc
    Department of Biochemistry, Faculty of Science, Charles University, Hlavova 2030, 128 43 Prague 2, Czech Republic
    Gen Physiol Biophys 23:423-33. 2004
    ..NDMA does not provide any type of binding spectra with used microsomal systems. Oxidative bio-activation of N-nitrosamines by the microsomal CYP isoforms was measured as formaldehyde formation...
  100. ncbi Tobacco-specific nitrosamines and their pyridine-N-glucuronides in the urine of smokers and smokeless tobacco users
    Irina Stepanov
    The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 14:885-91. 2005
    Tobacco-specific nitrosamines are believed to play a significant role as causes of cancer in people who use tobacco products...
  101. pmc The influence of repair pathways on the cytotoxicity and mutagenicity induced by the pyridyloxobutylation pathway of tobacco-specific nitrosamines
    Li Li
    Division of Environmental Health Sciences and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 22:1464-72. 2009
    Tobacco-specific nitrosamines, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine, are considered to be human carcinogens...

Research Grants67

  1. Prevention of EtOH-induced promotion of hepatocarcinogenesis by genistein/soy
    Martin J J Ronis; Fiscal Year: 2013
    ..of development of tumors initiated as a result of exposure to dietary and environmental carcinogens such as nitrosamines found in alcoholic beverages and cigarette smoke or via hepatitis infection...
  2. Case-Cohort Study of Cancers in Excess in Poultry Workers
    Eric S Johnson; Fiscal Year: 2013
    ..but also to other occupational carcinogens, including polycyclic aromatic hydrocarbons, heterocyclic amines, nitrosamines, benzene, etc...
  3. Biomarkers of NNK in prediction of lung cancer development in smokers
    Jian Min Yuan; Fiscal Year: 2013
    ..Tobacco- specific nitrosamines (i.e., NNK) in cigarette smoke is among the most important carcinogens that cause lung cancer in humans...
  4. ELECTROCATALYTIC STUDIES OF TOXIC POLLUTANT ACTIVATION
    James F Rusling; Fiscal Year: 2013
    ..Examples of bioactivated pollutants include styrene, benzo[a]pyrene, arylamines, and N-nitrosamines. We are developing in vitro biosensor arrays to rapidly measure the ability of metabolites to damage DNA and ..
  5. Biomarkers of toxic response to low nicotine cigarette smoke
    Andrew Strasser; Fiscal Year: 2012
    ..mixture including numerous toxic polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and nitrosamines such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in both the mainstream and sidestream (..
  6. Predictors of Smokeless Tobacco and Dual Use in the US Military
    Robert C Klesges; Fiscal Year: 2013
    ..0% vs. 3.3%). ST use is estimated to be the greatest exogenous source of human exposure to carcinogenic nitrosamines and has been associated with oral and extra-oral cancer as well as cardiovascular and cerebrovascular disease...
  7. Nicotinic Receptor Ligands and Tobacco-induced Lung Cancer
    Sergei A Grando; Fiscal Year: 2013
    ..our ongoing studies toward identification of molecular mechanisms mediating oncogenic effects of tobacco nitrosamines on respiratory cells and development of novel anti-cancer therapies using nicotinic acetylcholine receptor (..
  8. Biomarkers of exposure and response to environmental tobacco smoke in the pancrea
    Kenneth H Yu; Fiscal Year: 2013
    ..Cigarette smoke (CS) is an extremely complex mixture, including numerous tobacco-specific nitrosamines (TSNAs)...
  9. EPITHELIAL ACETYLCHOLINE IN ORAL BIOLOGY AND PATHOLOGY
    Sergei A Grando; Fiscal Year: 2012
    ..SLURPs and professional nicotinic antagonists can abolish, in part, the abilities of the nicotinederived nitrosamines 4-(methylnitrosamino)-1-(3[unreadable]pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine (NNN) to cause ..
  10. Metabolism of Carcinogenic Tobacco-Specific Nitrosamines
    Stephen S Hecht; Fiscal Year: 2013
    Cigarette smoking causes 30% of all cancer mortality in the developed world. Tobacco-specific nitrosamines, the subject of this proposal, are accepted causes of cancer in people who use tobacco products...
  11. Virtual High Throughput Screening: Specific Mechanism-based Inhibitors of CYP2E1
    Haoming Zhang; Fiscal Year: 2012
    ..that catalyzes the oxidation of a number of hepatotoxins and procarcinogens including ethanol, acetaminophen, nitrosamines, and carbon tetrachloride, among many others. CYP2E1 is highly inducible in human livers by alcohol...
  12. Benzo[a]pyrene metabolism: phenotyping and genotyping
    Stephen S Hecht; Fiscal Year: 2013
    ..role in lung cancer development in smokers: polycyclic aromatic hydrocarbons (PAH) and tobacco-specific nitrosamines, typified by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)...
  13. REALTIME waterpipe tobacco smoke toxicant sampling in the natural environment
    Alan Shihadeh; Fiscal Year: 2013
    ..fractions in the device, in particular for: particle number, particle mass, nicotine, tobacco-specific nitrosamines, and polycyclic aromatic hydrocarbons...
  14. Exploring current smokers? interest in using smokeless tobacco products
    RICHARD J O'CONNOR; Fiscal Year: 2013
    ..Novel smokeless tobacco products modeled on pasteurized Swedish snus, which is very low in tobacco-specific nitrosamines and appears to have low health risks, are now available in the US market...
  15. Rapid response human testing of smokeless tobacco products
    Pamela I Clark; Fiscal Year: 2013
    ..boost biomarkers that are sensitive to one-time use of a tobacco product, including salivary tobacco-specific nitrosamines (TSNAs) and polycyclic aromatic hydrocarbons (PAHs) and exhaled breath volatile organic compounds (VOCs), all ..
  16. Constituent yields and biomarkers of exposure for tobacco product regulation
    Irina Stepanov; Fiscal Year: 2013
    ..the analysis of tobacco products and biomarkers of exposure, we will focus on the carcinogenic tobacco-specific nitrosamines N2-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) to conduct research as ..
  17. Novel Determinants and Measures of Smokeless Tobacco Use
    Dorothy K Hatsukami; Fiscal Year: 2013
    ..S. smokeless tobacco (ST) products that contain different levels of tobacco specific nitrosamines (TSNAs), other carcinogens and nicotine on existing and novel biomarkers of exposure and effect...
  18. High Dose Nicotine Patch Therapy for Smokeless Tobacco Use
    Jon O Ebbert; Fiscal Year: 2010
    ..ST use is estimated to be the greatest exogenous source of human exposure to cancer-causing nitrosamines. ST has been associated with oral and extra-oral cancer as well as cardiovascular and cerebrovascular mortality...
  19. FORMATION AND METABOLISM OF NITROSAMINES IN PIGS
    Peter Magee; Fiscal Year: 1991
    ..2) To compare the activating and deactiviting metabolic pathways of the nitrosamines in the intact animal in vivo...
  20. Clinical Response to Biomarker Documentation of Child Secondhand Smoke Exposure
    ANNE JOSEPH; Fiscal Year: 2010
    ..Children who see providers in the experimental group will provide a urine sample to test for nitrosamines (a tobacco-specific carcinogen), nicotine and cotinine...
  21. ORAL CANCER--DNA POLYMORPHISMS IN CARCINOGEN METABOLISM
    Stephen Schwartz; Fiscal Year: 2001
    ..Oral carcinogens derived from these exposures include N-nitrosamines, polycyclic aromatic hydrocarbons, aromatic amines, heterocyclic amines, and acetaldehyde that are activated ..
  22. GENOTOXICITY IN CYP1A2 DEFICIENT TRANSGENIC MICE
    Daniel Nebert; Fiscal Year: 2002
    ..CYP1A2 substrates include environmentally important heterocyclic amines, nitrosamines, aflatoxins, nitrated polycyclic aromatic hydrocarbons, and arylamines such as 4-aminobiphenyl (ABP)...
  23. BIOMARKERS OF NNK AND NNN METABOLISM IN HUMANS
    Peter Foiles; Fiscal Year: 1993
    ..Among the most important carcinogens in cigarette smoke and smokeless tobacco are the tobacco specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'- nitrosonornicotine (NNN)...
  24. EPIDEMIOLOGY OF BARRETTS ESOPHAGUS
    Thomas Vaughan; Fiscal Year: 2000
    ..to be tested is that among patients with GERD: 1) cigarette smoking, alcohol consumption and dietary intake of nitrosamines are associated with increased risk of Barrett's esophagus, and that higher dietary intake and serum levels of ..
  25. CARCINOGENESIS--NITROSAMINE FORMATION AND INHIBITION
    RICHARD LOEPPKY; Fiscal Year: 1999
    ..toward this goal can be achieved through the development of chemistry for 1) the specific destruction of nitrosamines, 2) the specific scavenging of nitrosating agents, and 3) an understanding of the structural features which ..
  26. Nitrates, Nitrites, and Nitrosatable Drugs and Risk of Selected Birth Defects
    JEAN DIANE BRENDER; Fiscal Year: 2010
    ..Subjects'usual intake of dietary nitrates, nitrites, and nitrosamines will be calculated from the NBDPS food frequency questionnaire...
  27. ROLE OF ETHANOL IN THE ETIOLOGY OF HEAD & NECK CANCER
    G McCoy; Fiscal Year: 1992
    ..of cytochrome P450 induced by ethanol that is believed to participate in the metabolic activation of the N- nitrosamines. The link between ethanol consumption, metabolism, metabolic activity and enhanced tumor incidence will be ..
  28. Exploring Gene-Environment Factors in Child Brain Tumors
    Beth Mueller; Fiscal Year: 2004
    ..for the following genes: 1) Cytochrome P-450 (CYP) 2E1 and CYP 2D6, coding Phase I enzymes that activate nitrosamines and other chemicals into cancer-causing intermediates; 2) Glutathione S-transferase (GST) (GSTP1, GSTT1, and ..
  29. CO-CARCINOGENIC ACTIVITY OF NITROSAMINE METABOLITES
    Lisa Peterson; Fiscal Year: 2006
    The mechanism of tumor induction by unsymmetric nitrosamines is poorly understood. Alpha-hydroxylation activates these carcinogens to DNA alkylating agents by generating a metabolite that decomposes to an aldehyde and a diazohydroxide...
  30. TOBACCO CARCINOGENESIS AND CHEMOPREVENTION
    Karam El Bayoumy; Fiscal Year: 2005
    ..Besides containing carcinogenic agents such as the tobacco-specific nitrosamines [TSNA, e.g., 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone, (NNK)], the polycyclic aromatic hydrocarbons [e.g...
  31. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Polycyclic aromatic hydrocarbons (PAHs), nitrosamines, and N-heterocyclics are present in combustion products, e.g. grilled foods &cigarette smoke...
  32. Reactions of N-Nitroso Compounds with Heme
    GEORGE RICHTER ADDO; Fiscal Year: 2007
    ..metal-NO bond formation, but they are also associated with incidences of cancer after biochemical activation of nitrosamines and related compounds by the heme-containing cytochrome P450 enzyme...
  33. DNA DAMAGE INDUCED BY PANCREATROPIC NITROSAMINES
    Demetrius Kokkinakis; Fiscal Year: 1990
    ..of tissue and DNA of target and nontarget organs during treatment of hamsters and rats with radiolabeled nitrosamines, and also evaluate possible relations between tumor induction and persistence of various DNA adducts...
  34. GENETIC SUSCEPTIBILITY--CARCINOGENS IN PANCREATIC CANCER
    Donghui Li; Fiscal Year: 2001
    ..Half of these mutations are C to A transition, a point mutation induced by nitrosamines and other alkylating agents in experimental animals...
  35. NITROSYL AND NITROSO COMPLEXES OF METALLOPORPHYRINS
    GEORGE RICHTER ADDO; Fiscal Year: 2000
    ..The interaction of nitrosamines and thionitrites with the metalloporphyrins/chlorins will also be studied...
  36. GLUCURONIDATION OF DIETARY AND ENVIRONMENTAL CARCINOGENS
    Robert Tukey; Fiscal Year: 2002
    ..The P4501A2 directed oxidative metabolism of dietary HCAs found in cooked meat as well as N-nitrosamines that are generated in the condensation of smoke derived from nicotine are known carcinogens, and have been ..
  37. Analysis for Nitrosamines, Changing Cigarette, Additive
    DIETRICH HOFFMAN; Fiscal Year: 2003
    ..We specifically intend to extract citations of industry research on carcinogenic N-nitrosamines, especially the nicotine-derived N- nitros-amines in the changing cigarette (cigarette engineering and its ..
  38. Treatment of diabetic gastroparesis with nitric oxide
    Robert Raulli; Fiscal Year: 2007
    ..delivers NO in a predictable and controllable manner, and without the possibility of forming carcinogenic nitrosamines. NORTECH is uniquely able to deliver biologically active levels of NO for a sustained period at gastric pH (2...
  39. NITROSAMINE ACTIVATION AND EXTRAHEPATIC P450S
    Sharon Murphy; Fiscal Year: 1999
    DESCRIPTION: Nitrosamines are strongly carcinogenic in animals and are believed to be carcinogenic in humans as well. In rats, the esophagus is the most susceptible organ to tumor induction by nitrosamines...
  40. Nicotine Derived Nitrosamines & Tobacco Related Cancers
    TIMOTHY O CONNOR; Fiscal Year: 2005
    ..Nicotine-derived nitrosamines are cancer suspect agents that are found in tobacco, smokeless tobacco, tobacco smoke, and sidestream (..
  41. MODELS OF TOBACCO-ALCOHOL RELATED CARCINOGENESIS
    SIRAJ MUFTI; Fiscal Year: 1992
    ..Two potent tobacco specific nitrosamines, N-nitrosonornicotine and 2-(methylnitrosamino)-1-(3-pyridyl)- 1-butanone will be used to initiate ..
  42. BEHAVIOR OF NICOTINE AND N NITROSAMINES IN TOBACCO SMOKE
    James Pankow; Fiscal Year: 2000
    ..Establishing the underlying chemistry will be of considerable value. Since many of the highly carcinogenic N-nitrosamines undergo the same type of gas/particle partitioning exhibited by nicotine, the carcinogenicity of tobacco smoke ..
  43. METABOLISM & GENOTOXICITY OF NITROSAMINES
    Barry Gold; Fiscal Year: 1991
    ..Unlike acyclic N-nitrosamines, NPy does not yield a high level of DNA adducts' and to date no DNA adduct has been identified...
  44. TOBACCO AND CANCER RISK--DOSE, METABOLISM AND GENETICS
    Philip Lazarus; Fiscal Year: 2005
    ..It utilizes metabolic and molecular techniques to study pathways of activation of tobacco-derived nitrosamines related to lung cancer, which is higher in African Americans compared to Caucasians, as well as detoxification ..
  45. ENDOGENOUS ENALS IN NITROSAMINE CARCINOGENESIS
    Fung Lung Chung; Fiscal Year: 1992
    ..the applicant's abstract): The basic hypothesis is that enals are important in the induction of tumors by those nitrosamines which metabolically release them...
  46. FUNCT. CHARACTERIZATION OF HUMAN CYP2A6 GENETIC VARIANTS
    Jun yan Hong; Fiscal Year: 2002
    ..NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone (NNK), two major carcinogenic tobacco-specific nitrosamines, as well as in the metabolism of nicotine which is responsible for smoking addiction...
  47. Persistence of Alkylated DNA Carcinogenesis
    ANTHONY PEGG; Fiscal Year: 2009
    ..mechanism protecting from the carcinogenic, cytotoxic and mutagenic effects of alkylating agents including nitrosamines and nitrosamides, which are important human carcinogens...
  48. Quantitative Gene Expression in Human Lung Epithelium
    SIMON SPIVACK; Fiscal Year: 2007
    ..Tobacco smoke's composition includes polyaromatic hydrocarbons, nitrosamines, and aromatic amines...
  49. Dietary Nitrosamines and Risk of Pancreatic Cancer
    Donghui Li; Fiscal Year: 2009
    ..It is a cost effective study by using existing dietary data and DNA samples. Information generated from this study will be valuable in developing novel strategies for the primary prevention of pancreatic cancer. ..
  50. BIOASSAY OF SNUFF FOR CARCINOGENIC ACTIVITY IN RATS
    DIETRICH HOFFMAN; Fiscal Year: 1990
    ..in snuff has been extensively documented, in that volatile and especially carcinogenic tobacco- specific N-nitrosamines, polynuclear aromatic hydrocarbons, and polonium-210 have been identified in snuff products...
  51. MECHANISMS OF AT TA MUTAGENESIS IN EUKARYOTES
    Opinder Bhanot; Fiscal Year: 1999
    DESCRIPTION: Alkylating agents (e.g., methylating and ethylating nitrosamines) are likely to be important carcinogens. The relatively reactive ethylating agents (e.g...
  52. Lung Cancer Chemoprevention: Isothiocyanates, inositol
    Stephen Hecht; Fiscal Year: 2008
    ..abstract_text> ..
  53. METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINES
    Stephen Hecht; Fiscal Year: 2003
    ..S. Tobacco-specific N-nitrosamines are formed from tobacco alkaloids during the curing and processing of tobacco products...
  54. CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTS
    Stephen S Hecht; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): This proposal focuses on DNA adducts of four carcinogenic nitrosamines to which human exposure has been firmly established: A/-nitrosopyrrolidine (NPYR), A/-nitrosopiperidine (NPIP), A/-..
  55. Tobacco Carcinogenesis
    Stephen Hecht; Fiscal Year: 2005
    ..Dr. Sharon Murphy will discuss cytochrome P450-mediated metabolism of tobacco-specific nitrosamines and nicotine. Dr...
  56. The Role of Toll-Like Receptors in NPC
    YIN YAO; Fiscal Year: 2007
    ..environmental factors including infection with Epstein-Barr Virus (EBV) and intake of preserved food containing nitrosamines and nitrite...
  57. 13TH JERUSALEM SYMPOSIUM ON CARCINOGENESIS
    PAUL TS O; Fiscal Year: 1980
    ..The environmental aspect will include experts in polycyclic hydrocarbons, nitrosamines, aromatic amines and natural occurring carcinogens...
  58. STRUCTURAL REQUIREMENTS FOR NITROSAMINE CARCINOGENICITY
    MYRON JACOBSON; Fiscal Year: 1980
    The relative carcinogenicity of a number of conformationally biased N-nitrosamines appears to be related to the acidity of an hydrogen alpha to the nitrosamine function and in a plane perpendicular to that containing the nitrosamine and ..
  59. MOLECULAR MARKERS OF ORAL CANCER RISK
    Philip Lazarus; Fiscal Year: 2000
    ..tobacco carcinogens such as polycyclic aromatic hydrocarbons (PAHs) like benxo(a)pyrene, and tobacco-specific nitrosamines (TSNAs) such as 4-(methyl-nitrosamino)-1-(3-pyridyl)-butanone (NNK), the applicant further hypothesizes that ..
  60. Metabolism of Carcinogens and Drugs by Human P450s
    F Guengerich; Fiscal Year: 2005
    ..four of the major human P450s involved in drug and carcinogen metabolism and of particular significance with nitrosamines (2A6) and heterocyclic amines (1A2)...
  61. Gene-gene interaction in nasopharyngeal carcinoma
    YIN YAO; Fiscal Year: 2005
    ..These environmental factors include intake of preserved food containing nitrosamines and nitrite, cigarette smoking, and infection with Epstein-Barr Virus (EBV)...
  62. METABOLIC ACTIVATION OF CARCINOGENS
    Stephen Hecht; Fiscal Year: 2000
    ..The goal of the program is to understand the mechanisms by which environmentally prevalent nitrosamines and polynuclear aromatic hydrocarbons (PAHs) initiate the carcinogenic process...
  63. Preclin. model for prevention of NSCLC in former smokers
    HILDEGARD SCHULLER; Fiscal Year: 2006
    ....
  64. NNK, Beta-Adrenergic AA Release and Lung Cancer
    HILDEGARD SCHULLER; Fiscal Year: 2005
    ..2. To determine which products of the AA cascade are formed in untreated cells and in response to NNK, which of these products stimulate DNA synthesis, and what downstream effectors are activated by these products. ..
  65. CARCINOGENESIS--HIGHLY REACTIVE NITROSAMINES
    RICHARD LOEPPKY; Fiscal Year: 2001
    ..to understand the mechanism of the carcinogenesis of nitrosodiethanolamine (NDELA) and other beta-oxidized nitrosamines. Secondary alkanolamines are widely distributed and their nitrosoamine derivatives are documented in lubricants ..
  66. TREATMENT OF SMOKELESS TOBACCO USERS
    Dorothy Hatsukami; Fiscal Year: 2008
    ..PERFORMANCE SITE ========================================Section End=========================================== ..
  67. ENDOGENOUS NITROSATION CHEMISTRY IN CARCINOGENESIS
    RICHARD LOEPPKY; Fiscal Year: 2004
    ..Computational methods will be employed to reveal reaction paths of intermediates and lead to better predictions of the types of compounds which pose a carcinogenic threat through their endogenous nitrosation. ..