nitrosamines

Summary

Summary: A class of compounds that contain a -NH2 and a -NO radical. Many members of this group have carcinogenic and mutagenic properties.

Top Publications

  1. ncbi Progress and challenges in selected areas of tobacco carcinogenesis
    Stephen S Hecht
    University of Minnesota Cancer Center, MMC 806, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 21:160-71. 2008
  2. ncbi Nicotinic receptors mediate tumorigenic action of tobacco-derived nitrosamines on immortalized oral epithelial cells
    Juan Arredondo
    Department of Dermatology, University of California at Davis, Davis, California, USA
    Cancer Biol Ther 5:511-7. 2006
  3. ncbi Nitrosamines as nicotinic receptor ligands
    Hildegard M Schuller
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Life Sci 80:2274-80. 2007
  4. ncbi Beta-adrenergic modulation of NNK-induced lung carcinogenesis in hamsters
    H M Schuller
    Experimental Oncology Laboratory, College of Veterinary Medicine, University of Tennessee, Knoxville 37906, USA
    J Cancer Res Clin Oncol 126:624-30. 2000
  5. ncbi Cellular targets and mechanisms of nitros(yl)ation: an insight into their nature and kinetics in vivo
    Nathan S Bryan
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Proc Natl Acad Sci U S A 101:4308-13. 2004
  6. ncbi Processed meat consumption, dietary nitrosamines and stomach cancer risk in a cohort of Swedish women
    Susanna C Larsson
    Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 119:915-9. 2006
  7. ncbi Global surveillance of oral tobacco products: total nicotine, unionised nicotine and tobacco-specific N-nitrosamines
    Stephen B Stanfill
    Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, Emergency Response and Air Toxicants Branch, 4770 Buford Highway, Atlanta, Georgia 30341, USA
    Tob Control 20:e2. 2011
  8. ncbi Decreased levels of tobacco-specific N-nitrosamines in moist snuff on the Swedish market
    Bengt Göran Osterdahl
    Swedish National Food Administration, Box 622, SE 751 26 Uppsala, Sweden
    J Agric Food Chem 52:5085-8. 2004
  9. ncbi Mechanisms of smoking-related lung and pancreatic adenocarcinoma development
    Hildegard M Schuller
    Department of Pathology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, Tennessee 37996, USA
    Nat Rev Cancer 2:455-63. 2002
  10. ncbi A study to estimate and correlate cigarette smoke exposure in smokers in Germany as determined by filter analysis and biomarkers of exposure
    Christopher J Shepperd
    British American Tobacco, Group Research and Development, Regents Park Road, Millbrook, Southampton, Hampshire SO15 8TL, UK
    Regul Toxicol Pharmacol 55:97-109. 2009

Research Grants

  1. Biomarkers of toxic response to low nicotine cigarette smoke
    Andrew Strasser; Fiscal Year: 2010
  2. ELECTROCATALYTIC STUDIES OF TOXIC POLLUTANT ACTIVATION
    James F Rusling; Fiscal Year: 2010
  3. ELECTROCATALYTIC STUDIES OF TOXIC POLLUTANT ACTIVATION
    James F Rusling; Fiscal Year: 2011
  4. ELECTROCATALYTIC STUDIES OF TOXIC POLLUTANT ACTIVATION
    James Rusling; Fiscal Year: 2009
  5. ORAL CANCER--DNA POLYMORPHISMS IN CARCINOGEN METABOLISM
    Stephen Schwartz; Fiscal Year: 2001
  6. GENOTOXICITY IN CYP1A2 DEFICIENT TRANSGENIC MICE
    Daniel Nebert; Fiscal Year: 2002
  7. Predictors of Smokeless Tobacco and Dual Use in the US Military
    Robert C Klesges; Fiscal Year: 2010
  8. Predictors of Smokeless Tobacco and Dual Use in the US Military
    Robert Klesges; Fiscal Year: 2009
  9. Nitrates, Nitrites, and Nitrosatable Drugs and Risk of Selected Birth Defects
    JEAN DIANE BRENDER; Fiscal Year: 2010
  10. Nitrates, Nitrites, and Nitrosatable Drugs and Risk of Selected Birth Defects
    Jean Brender; Fiscal Year: 2009

Detail Information

Publications251 found, 100 shown here

  1. ncbi Progress and challenges in selected areas of tobacco carcinogenesis
    Stephen S Hecht
    University of Minnesota Cancer Center, MMC 806, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 21:160-71. 2008
    ..The topics covered include metabolism and DNA modification by tobacco-specific nitrosamines, tobacco carcinogen biomarkers, an unidentified DNA ethylating agent in cigarette smoke, mutations in the K-RAS ..
  2. ncbi Nicotinic receptors mediate tumorigenic action of tobacco-derived nitrosamines on immortalized oral epithelial cells
    Juan Arredondo
    Department of Dermatology, University of California at Davis, Davis, California, USA
    Cancer Biol Ther 5:511-7. 2006
    ..Emerging evidence indicates that nAChRs can be stimulated by the nicotine-derived nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine (NNN) that can induce oral ..
  3. ncbi Nitrosamines as nicotinic receptor ligands
    Hildegard M Schuller
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Life Sci 80:2274-80. 2007
    b>Nitrosamines are carcinogens formed in the mammalian organism from amine precursors contained in food, beverages, cosmetics and drugs. The potent carcinogen, NNK, and the weaker carcinogen, NNN, are nitrosamines formed from nicotine...
  4. ncbi Beta-adrenergic modulation of NNK-induced lung carcinogenesis in hamsters
    H M Schuller
    Experimental Oncology Laboratory, College of Veterinary Medicine, University of Tennessee, Knoxville 37906, USA
    J Cancer Res Clin Oncol 126:624-30. 2000
    ..We have recently shown that the growth of cell lines derived from human PACs is controlled by beta-adrenergic receptors, and that NNK is a high affinity agonist for this receptor family...
  5. ncbi Cellular targets and mechanisms of nitros(yl)ation: an insight into their nature and kinetics in vivo
    Nathan S Bryan
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Proc Natl Acad Sci U S A 101:4308-13. 2004
    ..The findings also raise the intriguing possibility that N-nitrosation is directly involved in the modulation of protein function...
  6. ncbi Processed meat consumption, dietary nitrosamines and stomach cancer risk in a cohort of Swedish women
    Susanna C Larsson
    Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 119:915-9. 2006
    ..b>Nitrosamines may be responsible for this association, but few studies have directly examined nitrosamine intake in relation ..
  7. ncbi Global surveillance of oral tobacco products: total nicotine, unionised nicotine and tobacco-specific N-nitrosamines
    Stephen B Stanfill
    Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, Emergency Response and Air Toxicants Branch, 4770 Buford Highway, Atlanta, Georgia 30341, USA
    Tob Control 20:e2. 2011
    Oral tobacco products contain nicotine and carcinogenic tobacco-specific N-nitrosamines (TSNAs) that can be absorbed through the oral mucosa...
  8. ncbi Decreased levels of tobacco-specific N-nitrosamines in moist snuff on the Swedish market
    Bengt Göran Osterdahl
    Swedish National Food Administration, Box 622, SE 751 26 Uppsala, Sweden
    J Agric Food Chem 52:5085-8. 2004
    Moist snuff, or snus, on the Swedish market in 2001 and 2002 was analyzed for tobacco-specific N-nitrosamines (TSNAs) using a recently developed LC-MS/MS method...
  9. ncbi Mechanisms of smoking-related lung and pancreatic adenocarcinoma development
    Hildegard M Schuller
    Department of Pathology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, Tennessee 37996, USA
    Nat Rev Cancer 2:455-63. 2002
  10. ncbi A study to estimate and correlate cigarette smoke exposure in smokers in Germany as determined by filter analysis and biomarkers of exposure
    Christopher J Shepperd
    British American Tobacco, Group Research and Development, Regents Park Road, Millbrook, Southampton, Hampshire SO15 8TL, UK
    Regul Toxicol Pharmacol 55:97-109. 2009
    ....
  11. ncbi Formation and accumulation of pyridyloxobutyl DNA adducts in F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol
    Yanbin Lao
    Department of Medicinal Chemistry, and the Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 20:235-45. 2007
    ....
  12. ncbi Tobacco-specific nitrosamines in new tobacco products
    Irina Stepanov
    The Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Nicotine Tob Res 8:309-13. 2006
    ..Tobacco-specific nitrosamines (TSNAs) are an important class of carcinogens in tobacco products, but virtually no data were available on ..
  13. ncbi Cell type specific, receptor-mediated modulation of growth kinetics in human lung cancer cell lines by nicotine and tobacco-related nitrosamines
    H M Schuller
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville 37901 1071
    Biochem Pharmacol 38:3439-42. 1989
    ..receptors in the mediation of cell type specific biological effects of nicotine and the two tobacco-related nitrosamines N-nitrosodiethylamine (DEN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) on human lung cells...
  14. ncbi Strain-specific spontaneous and NNK-mediated tumorigenesis in Pten+/- mice
    Mary Christine Hollander
    Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20889, USA
    Neoplasia 10:866-72. 2008
    ....
  15. ncbi Inhibition of adenoma progression to adenocarcinoma in a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis model in A/J mice by tea polyphenols and caffeine
    Gang Lu
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 16445-0687, USA
    Cancer Res 66:11494-501. 2006
    ..This effect is closely associated with decreased cell proliferation, enhanced apoptosis, and lowered levels of c-Jun and Erk1/2 phosphorylation...
  16. ncbi The nicotinic receptor antagonists abolish pathobiologic effects of tobacco-derived nitrosamines on BEP2D cells
    Juan Arredondo
    Department of Dermatology, University of California, Davis, 3301 C Street, Suite #1400, Sacramento, CA 95816, USA
    J Cancer Res Clin Oncol 132:653-63. 2006
    ..b>Nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine (NNN) can induce tumors both ..
  17. ncbi Tobacco-specific nitrosamines in smokeless tobacco products marketed in India
    Irina Stepanov
    The Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Int J Cancer 116:16-9. 2005
    Smokeless tobacco products are a known cause of oral cancer in India. Carcinogenic tobacco-specific nitrosamines in these products are believed to be at least partially responsible for cancer induction, but there have been no recent ..
  18. ncbi Levels of tobacco-specific nitrosamines and polycyclic aromatic hydrocarbons in mainstream smoke from different tobacco varieties
    Yan S Ding
    Emergency Response and Air Toxicants Branch, Division of Laboratory Science, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway Northeast, Mailstop F 47, Atlanta, GA 30341 3724, USA
    Cancer Epidemiol Biomarkers Prev 17:3366-71. 2008
    ..According to the IARC, 10 polycyclic aromatic hydrocarbons (PAH) and 8 tobacco-specific nitrosamines (TSNA), as well as at least 45 other compounds or substances found in tobacco smoke, are potential human ..
  19. ncbi Tobacco-specific nitrosamines in tobacco from U.S. brand and non-U.S. brand cigarettes
    David L Ashley
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Nicotine Tob Res 5:323-31. 2003
    Tobacco-specific nitrosamines (TSNAs) are one of the major classes of carcinogens found in tobacco products. As part of collaborative efforts to reduce tobacco use and resulting disease, the U.S...
  20. ncbi Comparative functional genomics analysis of NNK tobacco-carcinogen induced lung adenocarcinoma development in Gprc5a-knockout mice
    Junya Fujimoto
    Department of Thoracic Head and Neck Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 5:e11847. 2010
    ..Previously, we found that mice with a knockout (KO) of G-protein coupled receptor 5A (Gprc5a) develop lung tumors after a long latent period (12 to 24 months)...
  21. ncbi Effect of differing levels of tobacco-specific nitrosamines in cigarette smoke on the levels of biomarkers in smokers
    David L Ashley
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Cancer Epidemiol Biomarkers Prev 19:1389-98. 2010
    Smokers are exposed to significant doses of carcinogens, including tobacco-specific nitrosamines (TSNA)...
  22. ncbi Identification of adducts formed by pyridyloxobutylation of deoxyguanosine and DNA by 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone, a chemically activated form of tobacco specific carcinogens
    Mingyao Wang
    University of Minnesota Cancer Center, 420 Delaware Street SE, Mayo Mail Code 806, Minneapolis 55455, USA
    Chem Res Toxicol 16:616-26. 2003
    ..Adducts 23, 25, and 10 did not release HPB upon neutral thermal hydrolysis. The results of this study provide the first structural identification of an HPB-releasing DNA adduct of the tobacco specific nitrosamines NNK and NNN.
  23. ncbi Identification of O2-substituted pyrimidine adducts formed in reactions of 4-(acetoxymethylnitrosamino)- 1-(3-pyridyl)-1-butanone and 4-(acetoxymethylnitros- amino)-1-(3-pyridyl)-1-butanol with DNA
    Stephen S Hecht
    University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 17:588-97. 2004
    ..Furthermore, 26 was identified as a major 4-HPB releasing adduct of NNKCH(2)OAc. These results suggest that pyrimidine adducts of tobacco specific nitrosamines may be important contributors to their mutagenic and carcinogenic activity.
  24. ncbi Migration of nitrosamines from rubber products--are balloons and condoms harmful to the human health?
    Werner Altkofer
    Chemisches und Veterinaeruntersuchungsamt Stuttgart, Fellbach, Germany
    Mol Nutr Food Res 49:235-8. 2005
    Studies performed in 2001 and 2003 surveyed the release of carcinogenic nitrosamines and nitrosatable substances from rubber toy balloons by extraction with artificial saliva and gas chromatography-thermal energy analysis (GC-TEA)...
  25. ncbi Inhibitory effect of diet related sulphydryl compounds on the formation of carcinogenic nitrosamines
    N R Shenoy
    Bio Organic Division, Bhabha Atomic Research Centre, Trombay, Bombay, India
    Cancer Lett 65:227-32. 1992
    ..Toxicol., 25 (1987) 91-108). Several factors present in the diet can modify levels of endogenously formed nitrosamines by acting as catalysts or inhibitors...
  26. ncbi Characterization of new nitrosamines in drinking water using liquid chromatography tandem mass spectrometry
    Yuan-Yuan Zhao
    Environmental Health Sciences, School of Public Health and Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, 10-102 Clinical Sciences Building, Edmonton, Alberta, Canada T6G 2G3
    Environ Sci Technol 40:7636-41. 2006
    ..To comprehensively investigate the occurrence of possible nitrosamines in drinking water supplies, a liquid chromatography-tandem mass spectrometry technique was developed to detect ..
  27. ncbi Comparative metabolism of the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol by rat cytochrome P450 2A3 and human cytochrome P450 2A13
    John R Jalas
    Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA
    Drug Metab Dispos 31:1199-202. 2003
    ....
  28. ncbi Smoking reduction and tobacco-related cancers: the more things change, the more they stay the same
    Scott J Leischow
    J Natl Cancer Inst 96:86-7. 2004
  29. ncbi Detecting N-nitrosamines in drinking water at nanogram per liter levels using ammonia positive chemical ionization
    Jeffrey W A Charrois
    Department of Public Health Sciences, University of Alberta, 10 102 Clinical Sciences Building, Edmonton, Alberta, Canada T6G 2G3
    Environ Sci Technol 38:4835-41. 2004
    Detection of N-nitrosamines in water supplies is an environmental and public health issue because many N-nitrosamines are classified as probable human carcinogens...
  30. ncbi Increased expression of cyclooxygenase-2 in rat lung tumors induced by the tobacco-specific nitrosamine 4-(methylnitrosamino)-4-(3-pyridyl)-1-butanone: the impact of a high-fat diet
    K El-Bayoumy
    American Health Foundation, Valhalla, New York 10595, USA
    Cancer Res 59:1400-3. 1999
    ..This well-defined animal model is valuable for studying modulation of COX-2 expression in lung carcinogenesis by various factors, including dietary components...
  31. ncbi Smokeless tobacco and tobacco-related nitrosamines
    Vincent Cogliano
    WHO International Agency for Research on Cancer
    Lancet Oncol 5:708. 2004
  32. ncbi Tobacco-specific nitrosamines and their pyridine-N-glucuronides in the urine of smokers and smokeless tobacco users
    Irina Stepanov
    The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 14:885-91. 2005
    Tobacco-specific nitrosamines are believed to play a significant role as causes of cancer in people who use tobacco products...
  33. ncbi Surveillance of moist snuff: total nicotine, moisture, pH, un-ionized nicotine, and tobacco-specific nitrosamines
    Patricia Richter
    Office on Smoking and Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Nicotine Tob Res 10:1645-52. 2008
    ..Tobacco-specific nitrosamines (TSNAs) are potent carcinogens in smokeless tobacco products, and the pH of the product influences the content ..
  34. ncbi Modification by curcumin of mutagenic activation of carcinogenic N-nitrosamines by extrahepatic cytochromes P-450 2B1 and 2E1 in rats
    Yukio Mori
    Institute of Biological Pharmacy, Gifu Pharmaceutical University, 6 1, Mitahora higashi 5 chome, Gifu 502 8585, Japan
    Cancer Sci 97:896-904. 2006
    ..Further, the present findings suggest the potential of curcumin for modification of gastric and intestinal carcinogenesis initiated with NOC...
  35. ncbi Dose-dependent inhibition of tobacco smoke carcinogen-induced lung tumorigenesis in A/J mice by indole-3-carbinol
    Fekadu Kassie
    Masonic Cancer Center, University of Minnesota, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Cancer Prev Res (Phila) 1:568-76. 2008
    ....
  36. ncbi Development of estimates of dietary nitrates, nitrites, and nitrosamines for use with the Short Willet Food Frequency Questionnaire
    John S Griesenbeck
    Department of Social and Behavioral Health, School of Rural Public Health, Texas A and M Health Science Center, College Station, TX, USA
    Nutr J 8:16. 2009
    Studies have suggested that nitrates, nitrites, and nitrosamines have an etiologic role in adverse pregnancy outcomes and chronic diseases such as cancer...
  37. ncbi NNK activates ERK1/2 and CREB/ATF-1 via beta-1-AR and EGFR signaling in human lung adenocarcinoma and small airway epithelial cells
    Laag E
    Experimental Oncology Laboratory, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Int J Cancer 119:1547-52. 2006
    ..Collectively, our data provide evidence, for the first time, that NNK targets ERK1/2 and CREB/ATF-1 proteins via dual signaling involving beta 1-AR and EGFR pathways in PACCs and their putative cells of origin...
  38. ncbi Survival function of protein kinase C{iota} as a novel nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-activated bad kinase
    Zhaohui Jin
    University of Florida Shands Cancer Center, Department of Medicine, University of Florida, Gainesville, Florida 32610 0232, USA
    J Biol Chem 280:16045-52. 2005
    ....
  39. ncbi Volatile nitrosamines in foods on the Swedish market and estimation of their daily intake
    B G Osterdahl
    Swedish National Food Administration, Uppsala
    Food Addit Contam 5:587-95. 1988
    Foods on the Swedish market in 1980-1986 were analysed for volatile N-nitrosamines using gas chromatography-thermal energy analysis. Detectable levels were found in 474 of the 764 samples analysed...
  40. ncbi Rapid and sensitive gas chromatography-ion-trap tandem mass spectrometry method for the determination of tobacco-specific N-nitrosamines in secondhand smoke
    Mohamad Sleiman
    Indoor Environment Department, Environmental Energy Technologies Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 70 108B, Berkeley, CA 94720, USA
    J Chromatogr A 1216:7899-905. 2009
    Tobacco-specific nitrosamines (TSNAs) are some of the most potent carcinogens in tobacco and cigarette smoke. Accurate quantification of these chemicals is needed to help assess public health risks...
  41. ncbi 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone from cigarette smoke stimulates colon cancer growth via beta-adrenoceptors
    William K K Wu
    Department of Pharmacology, Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Cancer Res 65:5272-7. 2005
    ..These findings partly elucidate the carcinogenic actions of cigarette smoke and shed new light on the novel modulatory role of beta-adrenoceptors in the development of colon cancer...
  42. ncbi Cytochrome b5 reductase and cytochrome b5 support the CYP2E1-mediated activation of nitrosamines in a recombinant Ames test
    Vishwesh Mokashi
    Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536-0305, USA
    Arch Biochem Biophys 412:147-52. 2003
    ..Neither cytochrome b(5) reductase nor cytochrome b(5) alone could support CYP2E1 activity. These results demonstrate that the cytochrome b(5) reductase/cytochrome b(5) pathway can support CYP2E1 activity in bacterial cells...
  43. ncbi Opisthorchis viverrini infestation and endogenous nitrosamines as risk factors for cholangiocarcinoma in Thailand
    P Srivatanakul
    National Cancer Institute of Thailand, Bangkok
    Int J Cancer 48:821-5. 1991
    ..Small amounts of pre-formed nitrosamines were found in fermented fish and pork food items, which are consumed frequently in the high-risk area for CCA...
  44. ncbi Structural features of proteins responsible for resistance of tryptophan residues to nitrosylation
    Tatiana P Suntsova
    Institute of Molecular Genetics, Russian Academy of Sciences, 2 Kurchatov Sq, Moscow, 123182, Russia
    IUBMB Life 54:281-92. 2002
    ..This selection might explain both the resistance of tryptophan residues in proteins to nitrosation and the mechanisms of chemical communication by means of reversible nitrosation of proteins...
  45. ncbi A review: dietary and endogenously formed N-nitroso compounds and risk of childhood brain tumors
    Marion Dietrich
    School of Public Health, University of California Berkeley, Berkeley, CA 94720 7360, USA
    Cancer Causes Control 16:619-35. 2005
    ..NOC consist of two main groups, N-nitrosamines and N-nitrosamides...
  46. ncbi Rabbit liver microsomal system: study of interaction with two model N-nitrosamines and their metabolism
    M Sulc
    Department of Biochemistry, Faculty of Science, Charles University, Hlavova 2030, 128 43 Prague 2, Czech Republic
    Gen Physiol Biophys 23:423-33. 2004
    ..NDMA does not provide any type of binding spectra with used microsomal systems. Oxidative bio-activation of N-nitrosamines by the microsomal CYP isoforms was measured as formaldehyde formation...
  47. ncbi Subpicogram per milliliter determination of the tobacco-specific carcinogen metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human urine using liquid chromatography-tandem mass spectrometry
    Peyton Jacob
    Division of Clinical Pharmacology, University of California, San Francisco, UCSF Box 1220, San Francisco, California 94143 1220, USA
    Anal Chem 80:8115-21. 2008
    ..The lower limit of quantitation is 0.25 pg/mL for 5-mL urine specimens. Applications to studies of people with a range of different SHS exposure levels is described...
  48. ncbi A germ-line p53 mutation accelerates pulmonary tumorigenesis: p53-independent efficacy of chemopreventive agents green tea or dexamethasone/myo-inositol and chemotherapeutic agents taxol or adriamycin
    Z Zhang
    Department of Pathology, Medical College of Ohio, Toledo 43699, USA
    Cancer Res 60:901-7. 2000
    ..Furthermore, the lung adenomas generated in this model possess mutations in both the K-ras proto-oncogene and the p53 tumor suppressor gene. This model should prove directly useful for chemoprevention and chemotherapy studies...
  49. ncbi DNA adduct formation from tobacco-specific N-nitrosamines
    S S Hecht
    University of Minnesota Cancer Center Box 806, Mayo, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Mutat Res 424:127-42. 1999
    Tobacco-specific N-nitrosamines are a group of carcinogens derived from the tobacco alkaloids. They are likely causative factors for cancers of the lung, esophagus, pancreas, and oral cavity in people who use tobacco products...
  50. ncbi Expression of cell cycle proteins in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung tumors
    C L Sabourin
    Division of Environmental Health Sciences, School of Public Health, Ohio State University, Columbus, USA
    Exp Lung Res 24:499-521. 1998
    ..Furthermore, they demonstrate the importance of immunohistochemical studies to examine expression in tissues that contain multiple cell types, such as the lung, and in tumors that by nature are heterogeneous...
  51. ncbi Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines
    Gang Chen
    Cancer Prevention and Control Program, Penn State Cancer Institute, Department of Public Health Sciences, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Pharmacogenet Genomics 18:181-91. 2008
    ....
  52. ncbi Excretion of volatile nitrosamines in a rural population in relation to food and drinking water consumption
    P Levallois
    Département de médicine sociale et préventive, Universite Laval, Quebec, Canada
    Food Chem Toxicol 38:1013-9. 2000
    Urinary excretion of volatile nitrosamines was assessed in 59 non-smokers living in a rural county of Québec, Canada. Water and food intakes were measured by means of a 24-hour recall...
  53. ncbi Inhibition by vitamin C of apoptosis induced by N-nitrosamines in HepG2 and HL-60 cells
    Nuria Arranz
    Departamento de Nutricion, Bromatologia y Tecnologia de los Alimentos, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040 Madrid, Spain
    J Appl Toxicol 28:788-96. 2008
    ..Therefore, our findings suggest that inhibition of apoptosis may be one of the mechanisms by which vitamin C exerts its protective effect...
  54. ncbi Development of a food database of nitrosamines, heterocyclic amines, and polycyclic aromatic hydrocarbons
    Paula Jakszyn
    Catalan Institute of Oncology, L Hospitalet de Llobregat, Barcelona, Spain
    J Nutr 134:2011-4. 2004
    ..Our objective was to develop a food composition database of nitrates, nitrites, nitrosamines, HA, and PAH...
  55. ncbi Urinary tobacco-specific nitrosamines and 4-aminobiphenyl hemoglobin adducts measured in smokers of either regular or light cigarettes
    John T Bernert
    Division of Laboratory Science, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Nicotine Tob Res 7:729-38. 2005
    ..Thus the concentrations of the carcinogen biomarkers NNAL and 4-ABP in the smokers who regularly smoked light cigarettes were essentially the same as those in the smokers who chose regular cigarettes...
  56. ncbi Dependence of N-nitrosodimethylamine photodecomposition on the irradiation wavelength: excitation to the s(2) state as a doorway to the dimethylamine radical ground-state chemistry
    Daniel Pelaez
    Department of Physical Chemistry, Faculty of Sciences, University of Malaga, E 29071 Malaga, Spain
    J Org Chem 72:4741-9. 2007
    ....
  57. ncbi N(1)-acetyl-5-methoxykynuramine contrasts with other tryptophan metabolites by a peculiar type of NO scavenging: cyclization to a cinnolinone prevents formation of unstable nitrosamines
    R Hardeland
    J Pineal Res 43:104-5. 2007
  58. ncbi The influence of repair pathways on the cytotoxicity and mutagenicity induced by the pyridyloxobutylation pathway of tobacco-specific nitrosamines
    Li Li
    Division of Environmental Health Sciences and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 22:1464-72. 2009
    Tobacco-specific nitrosamines, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine, are considered to be human carcinogens...
  59. ncbi Concomitant presence of N-nitroso and S-nitroso proteins in human plasma
    Tienush Rassaf
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Free Radic Biol Med 33:1590-6. 2002
    ..Our findings may not only have important implications for the transport of NO in vivo, but also for cardiovascular disease diagnostics and the risk assessment of nitrosamine-related carcinogenesis in man...
  60. ncbi Formation of N-nitrosamines from eleven disinfection treatments of seven different surface waters
    Yuan Yuan Zhao
    Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, 10 102 Clinical Sciences Building, University of Alberta, Edmonton, Alberta, Canada T6G 2G3
    Environ Sci Technol 42:4857-62. 2008
    Formation of nine N-nitrosamines has been investigated when seven different source waters representing various qualities were each treated with eleven bench-scale disinfection processes, without addition of nitrosamine precursors...
  61. ncbi Molecular modeling of nitrosamines adsorbed on H-ZSM-5 zeolite: an ONIOM study
    Anawat Pinisakul
    Department of Chemistry, Faculty of Science, King Mongkut s University of Technology Thonburi, 126 Pracha utis Rd, Thung kru, Bangkok 10140, Thailand
    J Mol Model 14:1035-41. 2008
    ..Based on amino and imino isomers of nitrosamines, there are two adsorption configurations on the H-ZSM-5 for NA (as NA_a and NA_i), NMA (as NMA_a and NMA_i) and ..
  62. ncbi Development of liquid chromatography electrospray ionization tandem mass spectrometry methods for analysis of DNA adducts of formaldehyde and their application to rats treated with N-nitrosodimethylamine or 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
    Mingyao Wang
    University of Minnesota Cancer Center, MMC 806, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Chem Res Toxicol 20:1141-8. 2007
    ..results of this study demonstrate for the first time the presence of formaldehyde DNA adducts in tissues of rats treated with carcinogenic nitrosamines and suggest that these adducts may play a role in cancer induction by these compounds.
  63. ncbi Tobacco specific nitrosamines and potential reduced exposure products for smokers: a preliminary evaluation of Advance
    A B Breland
    Department of Psychology, Virginia Commonwealth University, Richmond, Virginia, USA
    Tob Control 12:317-21. 2003
    ..In the future, clinical methods like those described here may be valuable for evaluating PREPs before they are marketed publicly...
  64. ncbi Simultaneous determination of five tobacco-specific nitrosamines in mainstream cigarette smoke by isotope dilution liquid chromatography/electrospray ionization tandem mass spectrometry
    Weijia Wu
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, Georgia 30341, USA
    Anal Chem 75:4827-32. 2003
    Tobacco-specific nitrosamines (TSNAs) have been previously implicated as a source of carcinogenicity in tobacco and cigarette smoke. Accurate quantification of these chemicals is needed to help assess public health risk...
  65. ncbi NNK-induced hamster lung adenocarcinomas over-express beta2-adrenergic and EGFR signaling pathways
    Hildegard M Schuller
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Lung Cancer 49:35-45. 2005
    ..Taken together, these data point to PKA/CREB as novel targets for the development of cancer therapeutics for PAC patients non-responsive to EGFR-specific tyrosine kinase inhibitors...
  66. ncbi Nongenomic beta estrogen receptors enhance beta1 adrenergic signaling induced by the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human small airway epithelial cells
    Mourad Majidi
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Cancer Res 67:6863-71. 2007
    ..This novel cooperation between beta1AR and ERbeta signaling may contribute to the prominence of lung adenocarcinoma in women...
  67. ncbi Quantitation of pyridyloxobutyl DNA adducts of tobacco-specific nitrosamines in rat tissue DNA by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry
    Yanbin Lao
    Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 19:674-82. 2006
    The tobacco-specific nitrosamines N'-nitrosonornicotine (NNN, 1) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, 2) are potent carcinogens in rodents...
  68. ncbi Solid-phase microextraction of N-nitrosamines
    Janel E Grebel
    Environmental Science and Engineering Program, UCLA, School of Public Health, Charles E Young Drive South, Box 951772, Los Angeles, CA 90095, USA
    J Chromatogr A 1117:11-8. 2006
    ..The excellent selectivity of SPME in addition to the fast analysis time would make this method ideal for general surveys, wastewater analysis and laboratory studies (e.g. degradation kinetics or formation potential)...
  69. ncbi Smoke yields of tobacco-specific nitrosamines in relation to FTC tar level and cigarette manufacturer: analysis of the Massachusetts Benchmark Study
    J E Harris
    Massachusetts Institute of Technology, E52 252F, Cambridge, MA 02139, USA
    Public Health Rep 116:336-43. 2001
    This research assessed the relationship between the deliveries of carcinogenic tobacco-specific nitrosamines (TSNAs) and the Federal Trade Commission (FTC) "tar" ratings of US commercial cigarettes.
  70. ncbi Determination of tobacco-specific N-nitrosamines in urine of smokers and non-smokers
    Dominique Kavvadias
    Analytisch Biologisches Forschungslabor GmbH, Munich, Germany
    Biomarkers 14:547-53. 2009
    Tobacco-specific N-nitrosamines (TSNA) include 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), N'-nitrosonornicotine (NNN), N'-nitrosoanabasine (NAB) and N'-nitrosoanatabine (NAT) and are found in tobacco and tobacco smoke...
  71. ncbi Quantitation of pyridylhydroxybutyl-DNA adducts in liver and lung of F-344 rats treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol
    Pramod Upadhyaya
    Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street Southeast, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 21:1468-76. 2008
    ....
  72. ncbi Similar exposure to a tobacco-specific carcinogen in smokeless tobacco users and cigarette smokers
    Stephen S Hecht
    Cancer Center and Transdisciplinary Tobacco Use Research Center, University of Minnesota Cancer Center, 420 Delaware Street Southeast, MMC 806, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 16:1567-72. 2007
    ..001). These results show similar exposures to the potent tobacco-specific carcinogen NNK in smokeless tobacco users and smokers. These findings do not support the use of smokeless tobacco as a safe substitute for smoking...
  73. ncbi Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice
    Yan Weng
    Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, New York 12201 0509, USA
    Cancer Res 67:7825-32. 2007
    ....
  74. ncbi The association of a tobacco-specific biomarker and cigarette consumption and its dependence on host characteristics
    Jay H Lubin
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 16:1852-7. 2007
    ..Variations in the ratio with host characteristics were generally similar to a recent epidemiologic analysis of effect modification of the association between lung cancer and cigarette smoking...
  75. ncbi Urinary metabolites of a tobacco-specific lung carcinogen in nonsmoking hospitality workers
    Ozlem E Tulunay
    Tobacco Use Research Center, University of Minnesota, 2701 University Avenue Southeast, 201, Minneapolis, MN 55414, USA
    Cancer Epidemiol Biomarkers Prev 14:1283-6. 2005
    ..The results of this study show that smoke exposure in bars and restaurants may have important health effects on nonsmoking employees, elicited by the increase in carcinogen levels...
  76. ncbi Carcinogenic activity of cigarette smoke gas phase and its modulation by beta-carotene and N-acetylcysteine
    Hanspeter Witschi
    Center for Health and the Environment, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
    Toxicol Sci 84:81-7. 2005
    ..that in the filtered smoke the concentrations of polycyclic aromatic hydrocarbons and tobacco smoke specific nitrosamines were reduced to from below 18% to even nondetectable levels of the original values measured in the unfiltered ..
  77. ncbi Effects of cruciferous vegetable consumption on urinary metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in singapore chinese
    Stephen S Hecht
    University of Minnesota Cancer Center, Mayo Mail Code 806, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 13:997-1004. 2004
    ..The results of this study demonstrate the complexities in assessing effects of cruciferous vegetables on carcinogen metabolism...
  78. ncbi Tobacco-related-compound-induced nitrosative stress injury in the hamster cheek pouch
    R D C Barley
    Division of Oral and Maxillofacial Radiology, Department of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, DPC 2085, Edmonton, AB T6G 2N8, Canada
    J Dent Res 83:903-8. 2004
    ..005). Our results suggest that tobacco-related compounds, including nicotine, are genotoxic, and that 3-NT is a quantifiable marker of ONOO- damage in intact hamster cheek pouch tissues...
  79. ncbi Effect of celecoxib and novel agent LC-1 in a hamster model of lung cancer
    Reid C Vegeler
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Surg Res 143:169-76. 2007
    ..The therapeutic potential of celecoxib, a COX-2 selective inhibitor, and LC-1, a pro-apoptotic drug with accompanying inhibition of NF-kappaB, were investigated...
  80. ncbi The effects of dietary myoinositol on lung tumor development in tobacco smoke-exposed mice
    Hanspeter Witschi
    Center for Health and the Environment, University of California, Davis, California, USA
    Inhal Toxicol 16:195-201. 2004
    ..It was concluded that myoinositol has less chemopreventive activity against the full complex mixture of tobacco smoke than it has against selected constituents such as NNK or benzo[a]pyrene...
  81. ncbi Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces phosphorylation of mu- and m-calpain in association with increased secretion, cell migration, and invasion
    Lijun Xu
    University of Florida Shands Cancer Center, Department of Medicine and Department of Anatomy and Cell Biology, University of Florida, 1600 S W Archer Rd, Gainesville, FL 32610 0232, USA
    J Biol Chem 279:53683-90. 2004
    ....
  82. ncbi A comparison of urinary biomarkers of tobacco and carcinogen exposure in smokers
    Sharon E Murphy
    Transdisciplinary Tobacco Use Research Center, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 13:1617-23. 2004
    ..Whereas urinary concentrations of 1-hydroxypyrene were consistent across the four visits, the levels were not correlated with NNAL, anatabine, nicotine, or any nicotine metabolites...
  83. ncbi Exposure to nicotine and a tobacco-specific carcinogen increase with duration of use of smokeless tobacco
    S S Hecht
    Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Tob Control 17:128-31. 2008
    ..Smokeless tobacco is an efficient delivery vehicle for nicotine and can contain significant amounts of carcinogens. However, few studies have examined factors that might moderate levels of nicotine or carcinogen exposure...
  84. ncbi Induction of lung lesions in Wistar rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its inhibition by aspirin and phenethyl isothiocyanate
    Bo Ye
    Pathology Department, Basic Medical School, Wuhan University, Dong Hu Road, Wuhan, PR China
    BMC Cancer 7:90. 2007
    ..In the current study, we established a novel lung cancer model in Wistar rats treated with NNK. Using this model, we assessed the effects of two chemopreventive agents, aspirin and phenethyl isothiocyanate (PEITC), on tumor progression...
  85. ncbi Pre- and post-initiation chemoprevention activity of 2-alkyl/aryl selenazolidine-4(R)-carboxylic acids against tobacco-derived nitrosamine (NNK)-induced lung tumors in the A/J mouse
    Michael R Franklin
    University of Utah, Department of Pharmacology and Toxicology, Salt Lake City, UT 84112, USA
    Chem Biol Interact 168:211-20. 2007
    ..Thus, several 2-aryl/alkyl selenazolidines possess chemopreventive activity against NNK-induced lung tumors, and variously demonstrate pre-initiation and post-initiation efficacy...
  86. ncbi The chemopreventive effects of orally administered dexamethasone in Strain A/J mice following cessation of smoke exposure
    Hanspeter Witschi
    Center for Health and the Environment, University of California, Davis, California 95616, USA
    Inhal Toxicol 17:119-22. 2005
    ..It is concluded that the dietary intake of dexamethasone against full tobacco smoke might show improved chemopreventive activity when combined with other agents...
  87. ncbi Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice
    C Clifford Conaway
    American Health Foundation Cancer Center, Institute for Cancer Prevention, Valhalla, New York, USA
    Cancer Res 65:8548-57. 2005
    ..The results of the study provide a basis for future evaluation of the potential of phenethyl isothiocyanate and sulforaphane and their conjugates as chemopreventive agents in smokers and ex-smokers with early lung lesions...
  88. ncbi Acute and subacute effects of tobacco alkaloids, tobacco-specific nitrosamines and phenethyl isothiocyanate on N'-nitrosonornicotine metabolism in rats
    Stefan Tyroller
    Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilians University, Goethestrasse 33, D 80336 Munich, Germany
    Toxicology 215:245-53. 2005
    ..Further studies on the impact on smokers and the inhibitory effects of isothiocyanates are needed for a final risk assessment...
  89. ncbi Modification of an in vivo lung metastasis model of hepatocellular carcinoma by low dose N-nitrosomorpholine and diethylnitrosamine
    Hiroko Yoshino
    DIMS, Daiyu-kai Institute of Medical Sciences, Nishiazai, Azai-cho, Ichinomiya, Japan
    Clin Exp Metastasis 22:441-7. 2005
    ..Thus, it can be said that this system is a more appropriate model for elucidation of mechanisms of metastasis and also for analysis of factors to inhibit natural metastasis...
  90. ncbi Deguelin as a chemopreventive agent in mouse lung tumorigenesis induced by tobacco smoke carcinogens
    Stephen S Hecht
    J Natl Cancer Inst 97:1634-5. 2005
  91. ncbi Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis
    Ho Young Lee
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Cancer Inst 97:1695-9. 2005
    ..These results indicate that deguelin warrants consideration as a chemopreventive agent for early-stage lung carcinogenesis in a clinical lung cancer chemoprevention trial...
  92. ncbi The L84F and the I143V polymorphisms in the O6-methylguanine-DNA-methyltransferase (MGMT) gene increase human sensitivity to the genotoxic effects of the tobacco-specific nitrosamine carcinogen NNK
    Courtney E Hill
    Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, Texas 77555 1110, USA
    Pharmacogenet Genomics 15:571-8. 2005
    ..002). These new data suggest that the 84F and 143V cSNPs may alter the function characteristics of the MGMT protein, resulting in suboptimal repair of genetic damage induced by NNK...
  93. ncbi [Smoking as a risk factor for pancreatic cancer]
    Hidetaka Eguchi
    Department of Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation
    Nippon Rinsho 64:10-3. 2006
  94. ncbi Tobacco components stimulate Akt-dependent proliferation and NFkappaB-dependent survival in lung cancer cells
    Junji Tsurutani
    Cancer Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20889, USA
    Carcinogenesis 26:1182-95. 2005
    ..Collectively, these results identify tobacco component-induced, Akt-dependent proliferation and NFkappaB-dependent survival as cellular processes that could underlie the detrimental effects of smoking in cancer patients...
  95. ncbi Nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced pulmonary adenocarcinomas in Syrian golden hamsters contain beta 2-adrenergic receptor single-nucleotide polymorphisms
    Thomas Masi
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37996, USA
    Genes Chromosomes Cancer 44:212-7. 2005
    ....
  96. ncbi Lung as a new target in rats of 2-amino-3-methylimidazo[4,5-f]quinoline carcinogenesis: results of a two-stage model initiated with N-bis(2-hydroxypropyl)nitrosamine
    Yasuki Kitamura
    Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
    Cancer Sci 97:368-73. 2006
    ..The overall data clearly indicate that IQ is a potent lung carcinogen in rats, in which oxidative stress may not be involved in lung carcinogenesis...
  97. ncbi Re: Foulds and Ramstrom: Cancer Causes and Control 17: 227-228 (2006) and Henley et al., Cancer Causes and Control 16: 347-358 (2005). How smokeless tobacco can cause lung cancer
    Stephen S Hecht
    Cancer Causes Control 17:859-60. 2006
  98. ncbi Induction of pulmonary neoplasia in the smoke-exposed ferret by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): a model for human lung cancer
    Yuri Kim
    Nutrition and Cancer Biology Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Cancer Lett 234:209-19. 2006
    ....
  99. ncbi beta-carotene-induced changes in RARbeta isoform mRNA expression patterns do not influence lung adenoma multiplicity in the NNK-initiated A/J mouse model
    Regina Goralczyk
    DSM Nutritional Products Ltd, Research and Development, Human Nutrition and Health, Basel, Switzerland
    Nutr Cancer 54:252-62. 2006
    ..Down-regulation of RARbeta in NNK-induced adenoma-bearing lungs was similar to that observed in human lung cancer and further confirms the A/J-mouse as a valuable model for lung carcinogenesis...
  100. ncbi Understanding tobacco smoke carcinogen NNK and lung tumorigenesis
    Gohar Akopyan
    Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095-1747, USA
    Int J Oncol 29:745-52. 2006
    ..As such, it displays a fuller, more comprehensive overview, bringing us one step closer to understanding the fatal consequences of NNK, thus, discovering new avenues that successfully break the cycle of NNK-mediated lung carcinogenesis...
  101. ncbi Investigation of the role of lipoxygenase in bioactivation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human lung
    Leanne L Bedard
    Department of Pharmacology and Toxicology, Queen's University, Kingston, Ontario, Canada K7L 3N6
    Chem Res Toxicol 15:1267-73. 2002
    ..The inhibitory effect of 1-aminobenzotriazole and arachidonic acid on keto acid formation in the crude cytosols and in fraction 1, respectively (P < 0.05, N = 6), is consistent with hemoglobin-catalyzed NNK bioactivation...

Research Grants79

  1. Biomarkers of toxic response to low nicotine cigarette smoke
    Andrew Strasser; Fiscal Year: 2010
    ..mixture including numerous toxic polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and nitrosamines such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in both the mainstream and sidestream (..
  2. ELECTROCATALYTIC STUDIES OF TOXIC POLLUTANT ACTIVATION
    James F Rusling; Fiscal Year: 2010
    ..Examples of bioactivated pollutants include styrene, benzo[a]pyrene, arylamines, and N-nitrosamines. We are developing in vitro biosensor arrays to rapidly measure the ability of metabolites to damage DNA and ..
  3. ELECTROCATALYTIC STUDIES OF TOXIC POLLUTANT ACTIVATION
    James F Rusling; Fiscal Year: 2011
    ..Examples of bioactivated pollutants include styrene, benzo[a]pyrene, arylamines, and N-nitrosamines. We are developing in vitro biosensor arrays to rapidly measure the ability of metabolites to damage DNA and ..
  4. ELECTROCATALYTIC STUDIES OF TOXIC POLLUTANT ACTIVATION
    James Rusling; Fiscal Year: 2009
    ..Examples of bioactivated pollutants include styrene, benzo[a]pyrene, arylamines, and N-nitrosamines. We are developing in vitro biosensor arrays to rapidly measure the ability of metabolites to damage DNA and ..
  5. ORAL CANCER--DNA POLYMORPHISMS IN CARCINOGEN METABOLISM
    Stephen Schwartz; Fiscal Year: 2001
    ..Oral carcinogens derived from these exposures include N-nitrosamines, polycyclic aromatic hydrocarbons, aromatic amines, heterocyclic amines, and acetaldehyde that are activated ..
  6. GENOTOXICITY IN CYP1A2 DEFICIENT TRANSGENIC MICE
    Daniel Nebert; Fiscal Year: 2002
    ..CYP1A2 substrates include environmentally important heterocyclic amines, nitrosamines, aflatoxins, nitrated polycyclic aromatic hydrocarbons, and arylamines such as 4-aminobiphenyl (ABP)...
  7. Predictors of Smokeless Tobacco and Dual Use in the US Military
    Robert C Klesges; Fiscal Year: 2010
    ..0% vs. 3.3%). ST use is estimated to be the greatest exogenous source of human exposure to carcinogenic nitrosamines and has been associated with oral and extra-oral cancer as well as cardiovascular and cerebrovascular disease...
  8. Predictors of Smokeless Tobacco and Dual Use in the US Military
    Robert Klesges; Fiscal Year: 2009
    ..0% vs. 3.3%). ST use is estimated to be the greatest exogenous source of human exposure to carcinogenic nitrosamines and has been associated with oral and extra-oral cancer as well as cardiovascular and cerebrovascular disease...
  9. Nitrates, Nitrites, and Nitrosatable Drugs and Risk of Selected Birth Defects
    JEAN DIANE BRENDER; Fiscal Year: 2010
    ..Subjects'usual intake of dietary nitrates, nitrites, and nitrosamines will be calculated from the NBDPS food frequency questionnaire...
  10. Nitrates, Nitrites, and Nitrosatable Drugs and Risk of Selected Birth Defects
    Jean Brender; Fiscal Year: 2009
    ..Subjects' usual intake of dietary nitrates, nitrites, and nitrosamines will be calculated from the NBDPS food frequency questionnaire...
  11. Nitrates, Nitrites, and Nitrosatable Drugs and Risk of Selected Birth Defects
    Jean Brender; Fiscal Year: 2007
    ..Subjects' usual intake of dietary nitrates, nitrites, and nitrosamines will be calculated from the NBDPS food frequency questionnaire...
  12. Nitrates, Nitrites, and Nitrosatable Drugs and Risk of Selected Birth Defects
    Jean Brender; Fiscal Year: 2009
    ..Subjects' usual intake of dietary nitrates, nitrites, and nitrosamines will be calculated from the NBDPS food frequency questionnaire...
  13. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2009
    Polycyclic aromatic hydrocarbons (PAHs), nitrosamines, and N-heterocyclics are present in combustion products, e.g. grilled foods & cigarette smoke...
  14. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2009
    Polycyclic aromatic hydrocarbons (PAHs), nitrosamines, and N-heterocyclics are present in combustion products, e.g. grilled foods & cigarette smoke...
  15. INTERACTION OF ETHANOL WITH HEPATIC MICROSOMES
    Charles Lieber; Fiscal Year: 1992
    ..with respect to its ability to activate the structurally diverse chemical carcinogens dimethyl- and diethyl- nitrosamines, nitrosopyrolidine and vinylchloride...
  16. Exploring Gene-Environment Factors in Child Brain Tumors
    Beth Mueller; Fiscal Year: 2004
    ..for the following genes: 1) Cytochrome P-450 (CYP) 2E1 and CYP 2D6, coding Phase I enzymes that activate nitrosamines and other chemicals into cancer-causing intermediates; 2) Glutathione S-transferase (GST) (GSTP1, GSTT1, and ..
  17. METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINES
    Stephen Hecht; Fiscal Year: 2003
    ..S. Tobacco-specific N-nitrosamines are formed from tobacco alkaloids during the curing and processing of tobacco products...
  18. CO-CARCINOGENIC ACTIVITY OF NITROSAMINE METABOLITES
    Lisa Peterson; Fiscal Year: 2006
    The mechanism of tumor induction by unsymmetric nitrosamines is poorly understood. Alpha-hydroxylation activates these carcinogens to DNA alkylating agents by generating a metabolite that decomposes to an aldehyde and a diazohydroxide...
  19. GENOTOXICITY IN CYP1A2-DEFICIENT TRANSGENIC MICE
    Daniel Nebert; Fiscal Year: 1993
    ..NNK is one of the major tobacco smoke-specific nitrosamines that require CYP1A2 for metabolic activation...
  20. TOBACCO CARCINOGENESIS AND CHEMOPREVENTION
    Karam El Bayoumy; Fiscal Year: 2005
    ..Besides containing carcinogenic agents such as the tobacco-specific nitrosamines [TSNA, e.g., 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone, (NNK)], the polycyclic aromatic hydrocarbons [e.g...