nitrosamines

Summary

Summary: A class of compounds that contain a -NH2 and a -NO radical. Many members of this group have carcinogenic and mutagenic properties.

Top Publications

  1. ncbi Nicotinic receptors mediate tumorigenic action of tobacco-derived nitrosamines on immortalized oral epithelial cells
    Juan Arredondo
    Department of Dermatology, University of California at Davis, Davis, California, USA
    Cancer Biol Ther 5:511-7. 2006
  2. ncbi Metabolites of a tobacco-specific lung carcinogen in nonsmoking women exposed to environmental tobacco smoke
    K E Anderson
    Division of Epidemiology, University of Minnesota, Minneapolis 55454, USA
    J Natl Cancer Inst 93:378-81. 2001
  3. doi Global surveillance of oral tobacco products: total nicotine, unionised nicotine and tobacco-specific N-nitrosamines
    Stephen B Stanfill
    Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, Emergency Response and Air Toxicants Branch, 4770 Buford Highway, Atlanta, Georgia 30341, USA
    Tob Control 20:e2. 2011
  4. pmc Nitrosamines as nicotinic receptor ligands
    Hildegard M Schuller
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Life Sci 80:2274-80. 2007
  5. ncbi Mechanisms of smoking-related lung and pancreatic adenocarcinoma development
    Hildegard M Schuller
    Department of Pathology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, Tennessee 37996, USA
    Nat Rev Cancer 2:455-63. 2002
  6. ncbi Beta-adrenergic modulation of NNK-induced lung carcinogenesis in hamsters
    H M Schuller
    Experimental Oncology Laboratory, College of Veterinary Medicine, University of Tennessee, Knoxville 37906, USA
    J Cancer Res Clin Oncol 126:624-30. 2000
  7. doi 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone is correlated with 8-hydroxy-2'-deoxyguanosine in humans after exposure to environmental tobacco smoke
    Hung Che Chiang
    Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Zhunan, Miaoli County, Taiwan, ROC
    Sci Total Environ 414:134-9. 2012
  8. doi HSP70 and mucin 5B: novel protein targets of N,N'-dinitrosopiperazine-induced nasopharyngeal tumorigenesis
    Fa qing Tang
    Xiangya Hospital, Department of Pathology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China
    Cancer Sci 100:216-24. 2009
  9. ncbi Mutagenic activation of betel quid-specific N-nitrosamines catalyzed by human cytochrome P450 coexpressed with NADPH-cytochrome P450 reductase in Salmonella typhimurium YG7108
    Masafumi Miyazaki
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, N12W6, Kita ku, Sapporo 060 0812, Japan
    Mutat Res 581:165-71. 2005
  10. ncbi Metabolites of a tobacco-specific lung carcinogen in nonsmoking casino patrons
    Kristin E Anderson
    Division of Epidemiology, Comprehensive Cancer Center, University of Minnesota, Minneapolis, Minnesota 55454, USA
    Cancer Epidemiol Biomarkers Prev 12:1544-6. 2003

Research Grants

Detail Information

Publications269 found, 100 shown here

  1. ncbi Nicotinic receptors mediate tumorigenic action of tobacco-derived nitrosamines on immortalized oral epithelial cells
    Juan Arredondo
    Department of Dermatology, University of California at Davis, Davis, California, USA
    Cancer Biol Ther 5:511-7. 2006
    ..Emerging evidence indicates that nAChRs can be stimulated by the nicotine-derived nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine (NNN) that can induce oral ..
  2. ncbi Metabolites of a tobacco-specific lung carcinogen in nonsmoking women exposed to environmental tobacco smoke
    K E Anderson
    Division of Epidemiology, University of Minnesota, Minneapolis 55454, USA
    J Natl Cancer Inst 93:378-81. 2001
    ..We measured metabolites of a tobacco-specific lung carcinogen in urine from healthy, nonsmoking women exposed to ETS...
  3. doi Global surveillance of oral tobacco products: total nicotine, unionised nicotine and tobacco-specific N-nitrosamines
    Stephen B Stanfill
    Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, Emergency Response and Air Toxicants Branch, 4770 Buford Highway, Atlanta, Georgia 30341, USA
    Tob Control 20:e2. 2011
    Oral tobacco products contain nicotine and carcinogenic tobacco-specific N-nitrosamines (TSNAs) that can be absorbed through the oral mucosa...
  4. pmc Nitrosamines as nicotinic receptor ligands
    Hildegard M Schuller
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Life Sci 80:2274-80. 2007
    b>Nitrosamines are carcinogens formed in the mammalian organism from amine precursors contained in food, beverages, cosmetics and drugs. The potent carcinogen, NNK, and the weaker carcinogen, NNN, are nitrosamines formed from nicotine...
  5. ncbi Mechanisms of smoking-related lung and pancreatic adenocarcinoma development
    Hildegard M Schuller
    Department of Pathology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, Tennessee 37996, USA
    Nat Rev Cancer 2:455-63. 2002
  6. ncbi Beta-adrenergic modulation of NNK-induced lung carcinogenesis in hamsters
    H M Schuller
    Experimental Oncology Laboratory, College of Veterinary Medicine, University of Tennessee, Knoxville 37906, USA
    J Cancer Res Clin Oncol 126:624-30. 2000
    ..We have recently shown that the growth of cell lines derived from human PACs is controlled by beta-adrenergic receptors, and that NNK is a high affinity agonist for this receptor family...
  7. doi 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone is correlated with 8-hydroxy-2'-deoxyguanosine in humans after exposure to environmental tobacco smoke
    Hung Che Chiang
    Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Zhunan, Miaoli County, Taiwan, ROC
    Sci Total Environ 414:134-9. 2012
    ..Furthermore, this correlation supports the hypothesis that oxidative DNA damage is one of major adverse effects induced by ETS exposure in humans...
  8. doi HSP70 and mucin 5B: novel protein targets of N,N'-dinitrosopiperazine-induced nasopharyngeal tumorigenesis
    Fa qing Tang
    Xiangya Hospital, Department of Pathology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China
    Cancer Sci 100:216-24. 2009
    ..Our data indicate that DNP triggers over-expression of HSP70 and mucin 5B, and is involved in nasopharyngeal tumorigenesis. HSP70 and mucin 5B may be important targets in nasopharyngeal tumorigenesis induced by DNP...
  9. ncbi Mutagenic activation of betel quid-specific N-nitrosamines catalyzed by human cytochrome P450 coexpressed with NADPH-cytochrome P450 reductase in Salmonella typhimurium YG7108
    Masafumi Miyazaki
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, N12W6, Kita ku, Sapporo 060 0812, Japan
    Mutat Res 581:165-71. 2005
    ..Areca nut contained in the betel quid is believed to give rise to carcinogenic N-nitrosamines. In the present study, the roles of human cytochromes P450 (P450 or CYP) in the mutagenic activation of betel ..
  10. ncbi Metabolites of a tobacco-specific lung carcinogen in nonsmoking casino patrons
    Kristin E Anderson
    Division of Epidemiology, Comprehensive Cancer Center, University of Minnesota, Minneapolis, Minnesota 55454, USA
    Cancer Epidemiol Biomarkers Prev 12:1544-6. 2003
    ..044 nmol/mg creatinine, P < 0.0001) and total NNAL (0.018 pmol/mg creatinine, P < 0.001). These findings demonstrate that exposure of nonsmokers to ETS in a commercial setting results in uptake of a tobacco-specific lung carcinogen...
  11. pmc Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells
    Kip A West
    Cancer Therapeutics Branch, Cell and Cancer Biology Branch, National Cancer Institute, Bethesda, Maryland 20889, USA
    J Clin Invest 111:81-90. 2003
    ..Redundant Akt activation by nicotine and NNK could contribute to tobacco-related carcinogenesis by regulating two processes critical for tumorigenesis, cell growth and apoptosis...
  12. ncbi Understanding tobacco smoke carcinogen NNK and lung tumorigenesis
    Gohar Akopyan
    Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095 1747, USA
    Int J Oncol 29:745-52. 2006
    ..As such, it displays a fuller, more comprehensive overview, bringing us one step closer to understanding the fatal consequences of NNK, thus, discovering new avenues that successfully break the cycle of NNK-mediated lung carcinogenesis...
  13. ncbi Cell type specific, receptor-mediated modulation of growth kinetics in human lung cancer cell lines by nicotine and tobacco-related nitrosamines
    H M Schuller
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville 37901 1071
    Biochem Pharmacol 38:3439-42. 1989
    ..receptors in the mediation of cell type specific biological effects of nicotine and the two tobacco-related nitrosamines N-nitrosodiethylamine (DEN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) on human lung cells...
  14. ncbi A study to estimate and correlate cigarette smoke exposure in smokers in Germany as determined by filter analysis and biomarkers of exposure
    Christopher J Shepperd
    British American Tobacco, Group Research and Development, Regents Park Road, Millbrook, Southampton, Hampshire SO15 8TL, UK
    Regul Toxicol Pharmacol 55:97-109. 2009
    ....
  15. ncbi Decreased levels of tobacco-specific N-nitrosamines in moist snuff on the Swedish market
    Bengt Göran Osterdahl
    Swedish National Food Administration, Box 622, SE 751 26 Uppsala, Sweden
    J Agric Food Chem 52:5085-8. 2004
    Moist snuff, or snus, on the Swedish market in 2001 and 2002 was analyzed for tobacco-specific N-nitrosamines (TSNAs) using a recently developed LC-MS/MS method...
  16. ncbi Characterization and mapping of DNA damage induced by reactive metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) at nucleotide resolution in human genomic DNA
    J F Cloutier
    Laboratory of Cancer Etiology and Chemoprevention, Faculty of Pharmacy, Laval University, Quebec City, G1K 7P4, Canada
    J Mol Biol 313:539-57. 2001
    ..These results represent the first step in determining if NNK pyridyloxobutylates DNA with sequence specificity similar to those observed with other model compounds...
  17. ncbi Evidence for the epidermal growth factor receptor as a target for lung cancer prevention
    Fulvio Lonardo
    Harper Hospital, Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Clin Cancer Res 8:54-60. 2002
    ..RA effects on epidermal growth factor (EGF) induction of EGFR-phosphotyrosine levels, cyclin D1 expression and mitogenesis were examined in BEAS-2B cells...
  18. ncbi Intragastric volatile N-nitrosamines, nitrite, pH, and Helicobacter pylori during long-term treatment with omeprazole
    I T Vermeer
    Department of Health Risk Analysis and Toxicology, Maastricht University, Maastricht, The Netherlands
    Gastroenterology 121:517-25. 2001
    This study evaluated the effect of long-term gastric acid suppressive therapy with omeprazole on intragastric levels of carcinogenic N-nitrosamines and related parameters.
  19. ncbi Effects of antibodies induced by a conjugate vaccine on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone absorptive transport, metabolism, and proliferation of human lung cells
    Stefan S De Buck
    Institute of Immunology, LNS CRP Santé, Luxembourg, Grand Duchy of Luxembourg
    Int J Cancer 127:513-20. 2010
    ..These in vitro data therefore suggest that a prophylactic antibody response may be associated with a reduced risk of cancer...
  20. ncbi Stability of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in urine samples stored at various temperatures
    Yang Xia
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, Atlanta, Georgia 30341, USA
    J Anal Toxicol 34:411-5. 2010
    ..These results suggest that valid NNAL concentrations can be measured in frozen urine samples that have been stored for an extended period of time prior to analysis...
  21. ncbi [Profile of telomerase and telomerase RNA expression in nasopharyngeal carcinogenesis of rats induced by N, N'dinitrosopiperazine (DNP)]
    F Tang
    Xiangya Hospital, Hunan Medical University, Changsha 410078, China
    Zhonghua Bing Li Xue Za Zhi 30:125-8. 2001
    ..To investigate the profile of telomerase and telomerase RNA expression in nasopharyngeal carcinogenesis (NPC) induced by N, N'dinitrosopiperazine (DNP) and examined histolofically...
  22. pmc Maternal characteristics associated with the dietary intake of nitrates, nitrites, and nitrosamines in women of child-bearing age: a cross-sectional study
    John S Griesenbeck
    Department of Epidemiology and Biostatistics, School of Rural Public Health, Texas A and M Health Science Center, College Station, TX, 77843 1266, USA
    Environ Health 9:10. 2010
    ..Very little information is available on intake of nitrates, nitrites, and nitrosamines and factors related to increased consumption of these compounds.
  23. ncbi Predicting the mutagenicity of tobacco-related N-nitrosamines in humans using 11 strains of Salmonella typhimurium YG7108, each coexpressing a form of human cytochrome P450 along with NADPH-cytochrome P450 reductase
    K Fujita
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Environ Mol Mutagen 38:339-46. 2001
    Tobacco, including snuff and chewing tobacco, contains N-nitrosamines such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), N-nitrosodiethylamine (NDEA), N-nitrosopyrrolidine (NPYR), N-nitrosopiperidine (NPIP), N-nitrosomorpholine ..
  24. pmc Nitrosamine and related food intake and gastric and oesophageal cancer risk: a systematic review of the epidemiological evidence
    Paula Jakszyn
    Unit of Nutrition, Environment and Cancer, Department of Epidemiology and Cancer Registry, Institut Catala d Oncologia, ICO IDIBELL, L Hospitalet de LLobregrat 08907, Barcelona, Spain
    World J Gastroenterol 12:4296-303. 2006
    ..To study the association between nitrite and nitrosamine intake and gastric cancer (GC), between meat and processed meat intake, GC and oesophageal cancer (OC), and between preserved fish, vegetable and smoked food intake and GC...
  25. pmc Enhancive effect of N,N'-dinitrosopiperazine on inducing precancerous lesion on nasal and/or nasopharyngeal epithelia of TgN(p53mt-LMP1)/HT mice
    Dao fa Tian
    Faculty of Integrative Medicine, Chinese Medicine University of Hunan, and Department of Clinical Laboratory, the First Xiangya Hospital, Changsha 410007, China
    J Zhejiang Univ Sci B 10:172-9. 2009
    ....
  26. ncbi Inhibition of adenoma progression to adenocarcinoma in a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis model in A/J mice by tea polyphenols and caffeine
    Gang Lu
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 16445 0687, USA
    Cancer Res 66:11494-501. 2006
    ..This effect is closely associated with decreased cell proliferation, enhanced apoptosis, and lowered levels of c-Jun and Erk1/2 phosphorylation...
  27. pmc N,N'-dinitrosopiperazine-mediated ezrin protein phosphorylation via activation of Rho kinase and protein kinase C is involved in metastasis of nasopharyngeal carcinoma 6-10B cells
    Faqing Tang
    Medical Research Center, Zhuhai Hospital, Guangzhou 510000, Guangdong, China
    J Biol Chem 286:36956-67. 2011
    ..DNP may be involved in NPC metastasis through regulation of ezrin phosphorylation at Thr-567...
  28. doi The molecular basis for induction of human cancers by tobacco specific nitrosamines
    Robert Nilsson
    Department of Genetics, Microbiology and Toxicology, Stockholm University, Svante Arrhenius väg 16E, Frescati, S 106 91 Stockholm, Sweden
    Regul Toxicol Pharmacol 60:268-80. 2011
    ..For carcinogenic oral snuffs with extremely high concentrations of tobacco specific nitrosamines (TSNA) the DNA adduct levels predicted from animal experiments exceed those found in "unexposed" individuals...
  29. ncbi Combination experiments with very low doses of three genotoxic N-nitrosamines with similar organotropic carcinogenicity in rats
    M R Berger
    Institute of Toxicology and Chemotherapy, German Cancer Research Center, Heidelberg, FRG
    Carcinogenesis 8:1635-43. 1987
    ..The N-nitrosamines were administered throughout the rats' lives individually and in combination at three logarithmically spaced ..
  30. ncbi Cytochrome P450 2A-catalyzed metabolic activation of structurally similar carcinogenic nitrosamines: N'-nitrosonornicotine enantiomers, N-nitrosopiperidine, and N-nitrosopyrrolidine
    Hansen L Wong
    University of Minnesota, The Cancer Center, 420 Delaware Street SE, Mayo Mail Code 806, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 18:61-9. 2005
    ..These nitrosamines may be causative agents in human cancer...
  31. doi Red meat, dietary nitrosamines, and heme iron and risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Paula Jakszyn
    Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, AV gran via 199 08907, L Hospitalet de Llobregat, Barcelona, Spain
    Cancer Epidemiol Biomarkers Prev 20:555-9. 2011
    Previous epidemiologic studies found inconsistent results for the association between red meat intake, nitrosamines [NDMA: N-nitrosodimethylamine, and ENOC (endogenous nitroso compounds)], and the risk of bladder cancer...
  32. pmc Urine cotinine underestimates exposure to the tobacco-derived lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in passive compared with active smokers
    Neal Benowitz
    Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 1220, USA
    Cancer Epidemiol Biomarkers Prev 19:2795-800. 2010
    ....
  33. doi N-nitrosamines are associated with shorter telomere length
    Huiqi Li
    Section of Occupational and Environmental Medicine, Lund University Hospital, SE 221 85 Lund, Sweden
    Scand J Work Environ Health 37:316-24. 2011
    ..Aiming to examine the relationship between DNA-damaging agents and average telomere length in peripheral blood, we conducted a cross-sectional study among 157 workers working in the rubber industry in Sweden...
  34. pmc Elimination kinetics of the tobacco-specific biomarker and lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol
    Maciej L Goniewicz
    Department of Medicine, University of California, San Francisco, USA
    Cancer Epidemiol Biomarkers Prev 18:3421-5. 2009
    ....
  35. ncbi Levels of tobacco-specific nitrosamines and polycyclic aromatic hydrocarbons in mainstream smoke from different tobacco varieties
    Yan S Ding
    Emergency Response and Air Toxicants Branch, Division of Laboratory Science, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway Northeast, Mailstop F 47, Atlanta, GA 30341 3724, USA
    Cancer Epidemiol Biomarkers Prev 17:3366-71. 2008
    ..According to the IARC, 10 polycyclic aromatic hydrocarbons (PAH) and 8 tobacco-specific nitrosamines (TSNA), as well as at least 45 other compounds or substances found in tobacco smoke, are potential human ..
  36. ncbi Tobacco-specific nitrosamines in tobacco from U.S. brand and non-U.S. brand cigarettes
    David L Ashley
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Nicotine Tob Res 5:323-31. 2003
    Tobacco-specific nitrosamines (TSNAs) are one of the major classes of carcinogens found in tobacco products. As part of collaborative efforts to reduce tobacco use and resulting disease, the U.S...
  37. ncbi Tobacco-specific nitrosamines in smokeless tobacco products marketed in India
    Irina Stepanov
    The Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Int J Cancer 116:16-9. 2005
    Smokeless tobacco products are a known cause of oral cancer in India. Carcinogenic tobacco-specific nitrosamines in these products are believed to be at least partially responsible for cancer induction, but there have been no recent ..
  38. pmc Comparative functional genomics analysis of NNK tobacco-carcinogen induced lung adenocarcinoma development in Gprc5a-knockout mice
    Junya Fujimoto
    Department of Thoracic Head and Neck Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 5:e11847. 2010
    ..Previously, we found that mice with a knockout (KO) of G-protein coupled receptor 5A (Gprc5a) develop lung tumors after a long latent period (12 to 24 months)...
  39. ncbi Smoking reduction and tobacco-related cancers: the more things change, the more they stay the same
    Scott J Leischow
    J Natl Cancer Inst 96:86-7. 2004
  40. ncbi Inhibitory effect of diet related sulphydryl compounds on the formation of carcinogenic nitrosamines
    N R Shenoy
    Bio Organic Division, Bhabha Atomic Research Centre, Trombay, Bombay, India
    Cancer Lett 65:227-32. 1992
    ..Toxicol., 25 (1987) 91-108). Several factors present in the diet can modify levels of endogenously formed nitrosamines by acting as catalysts or inhibitors...
  41. ncbi Migration of nitrosamines from rubber products--are balloons and condoms harmful to the human health?
    Werner Altkofer
    Chemisches und Veterinaeruntersuchungsamt Stuttgart, Fellbach, Germany
    Mol Nutr Food Res 49:235-8. 2005
    Studies performed in 2001 and 2003 surveyed the release of carcinogenic nitrosamines and nitrosatable substances from rubber toy balloons by extraction with artificial saliva and gas chromatography-thermal energy analysis (GC-TEA)...
  42. ncbi Comparative metabolism of the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol by rat cytochrome P450 2A3 and human cytochrome P450 2A13
    John R Jalas
    Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA
    Drug Metab Dispos 31:1199-202. 2003
    ....
  43. ncbi The nicotinic receptor antagonists abolish pathobiologic effects of tobacco-derived nitrosamines on BEP2D cells
    Juan Arredondo
    Department of Dermatology, University of California, Davis, 3301 C Street, Suite 1400, Sacramento, CA 95816, USA
    J Cancer Res Clin Oncol 132:653-63. 2006
    ..b>Nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine (NNN) can induce tumors both ..
  44. ncbi Tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces cell proliferation in normal human bronchial epithelial cells through NFkappaB activation and cyclin D1 up-regulation
    Yuan Soon Ho
    Graduate Institute of Biomedical Technology, Taipei Medical University, Taipei, Taiwan
    Toxicol Appl Pharmacol 205:133-48. 2005
    ..In summary, our findings demonstrate for the first time that NNK could stimulate normal human bronchial cell proliferation through activation of the NFkappaB, which in turn up-regulated the cyclin D1 expression...
  45. ncbi Effect of differing levels of tobacco-specific nitrosamines in cigarette smoke on the levels of biomarkers in smokers
    David L Ashley
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Cancer Epidemiol Biomarkers Prev 19:1389-98. 2010
    Smokers are exposed to significant doses of carcinogens, including tobacco-specific nitrosamines (TSNA)...
  46. ncbi Processed meat consumption, dietary nitrosamines and stomach cancer risk in a cohort of Swedish women
    Susanna C Larsson
    Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 119:915-9. 2006
    ..b>Nitrosamines may be responsible for this association, but few studies have directly examined nitrosamine intake in relation ..
  47. ncbi Tobacco-specific nitrosamines in new tobacco products
    Irina Stepanov
    The Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Nicotine Tob Res 8:309-13. 2006
    ..Tobacco-specific nitrosamines (TSNAs) are an important class of carcinogens in tobacco products, but virtually no data were available on ..
  48. ncbi Detecting N-nitrosamines in drinking water at nanogram per liter levels using ammonia positive chemical ionization
    Jeffrey W A Charrois
    Department of Public Health Sciences, University of Alberta, 10 102 Clinical Sciences Building, Edmonton, Alberta, Canada T6G 2G3
    Environ Sci Technol 38:4835-41. 2004
    Detection of N-nitrosamines in water supplies is an environmental and public health issue because many N-nitrosamines are classified as probable human carcinogens...
  49. ncbi Identification of O2-substituted pyrimidine adducts formed in reactions of 4-(acetoxymethylnitrosamino)- 1-(3-pyridyl)-1-butanone and 4-(acetoxymethylnitros- amino)-1-(3-pyridyl)-1-butanol with DNA
    Stephen S Hecht
    University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 17:588-97. 2004
    ..Furthermore, 26 was identified as a major 4-HPB releasing adduct of NNKCH(2)OAc. These results suggest that pyrimidine adducts of tobacco specific nitrosamines may be important contributors to their mutagenic and carcinogenic activity.
  50. pmc Cellular targets and mechanisms of nitros(yl)ation: an insight into their nature and kinetics in vivo
    Nathan S Bryan
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Proc Natl Acad Sci U S A 101:4308-13. 2004
    ..The findings also raise the intriguing possibility that N-nitrosation is directly involved in the modulation of protein function...
  51. ncbi Identification of adducts formed by pyridyloxobutylation of deoxyguanosine and DNA by 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone, a chemically activated form of tobacco specific carcinogens
    Mingyao Wang
    University of Minnesota Cancer Center, 420 Delaware Street SE, Mayo Mail Code 806, Minneapolis 55455, USA
    Chem Res Toxicol 16:616-26. 2003
    ..Adducts 23, 25, and 10 did not release HPB upon neutral thermal hydrolysis. The results of this study provide the first structural identification of an HPB-releasing DNA adduct of the tobacco specific nitrosamines NNK and NNN.
  52. ncbi Characterization of new nitrosamines in drinking water using liquid chromatography tandem mass spectrometry
    Yuan Yuan Zhao
    Environmental Health Sciences, School of Public Health and Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, 10 102 Clinical Sciences Building, Edmonton, Alberta, Canada T6G 2G3
    Environ Sci Technol 40:7636-41. 2006
    ..To comprehensively investigate the occurrence of possible nitrosamines in drinking water supplies, a liquid chromatography-tandem mass spectrometry technique was developed to detect ..
  53. pmc Formation and accumulation of pyridyloxobutyl DNA adducts in F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol
    Yanbin Lao
    Department of Medicinal Chemistry, and the Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 20:235-45. 2007
    ....
  54. pmc Strain-specific spontaneous and NNK-mediated tumorigenesis in Pten+/- mice
    Mary Christine Hollander
    Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20889, USA
    Neoplasia 10:866-72. 2008
    ....
  55. ncbi Increased expression of cyclooxygenase-2 in rat lung tumors induced by the tobacco-specific nitrosamine 4-(methylnitrosamino)-4-(3-pyridyl)-1-butanone: the impact of a high-fat diet
    K El-Bayoumy
    American Health Foundation, Valhalla, New York 10595, USA
    Cancer Res 59:1400-3. 1999
    ..This well-defined animal model is valuable for studying modulation of COX-2 expression in lung carcinogenesis by various factors, including dietary components...
  56. ncbi Smokeless tobacco and tobacco-related nitrosamines
    Vincent Cogliano
    WHO International Agency for Research on Cancer
    Lancet Oncol 5:708. 2004
  57. pmc Dose-dependent inhibition of tobacco smoke carcinogen-induced lung tumorigenesis in A/J mice by indole-3-carbinol
    Fekadu Kassie
    Masonic Cancer Center, University of Minnesota, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Cancer Prev Res (Phila) 1:568-76. 2008
    ....
  58. ncbi N(1)-acetyl-5-methoxykynuramine contrasts with other tryptophan metabolites by a peculiar type of NO scavenging: cyclization to a cinnolinone prevents formation of unstable nitrosamines
    R Hardeland
    J Pineal Res 43:104-5. 2007
  59. ncbi A review: dietary and endogenously formed N-nitroso compounds and risk of childhood brain tumors
    Marion Dietrich
    School of Public Health, University of California Berkeley, Berkeley, CA 94720 7360, USA
    Cancer Causes Control 16:619-35. 2005
    ..NOC consist of two main groups, N-nitrosamines and N-nitrosamides...
  60. ncbi 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone from cigarette smoke stimulates colon cancer growth via beta-adrenoceptors
    William K K Wu
    Department of Pharmacology, Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Cancer Res 65:5272-7. 2005
    ..These findings partly elucidate the carcinogenic actions of cigarette smoke and shed new light on the novel modulatory role of beta-adrenoceptors in the development of colon cancer...
  61. ncbi Expression of cell cycle proteins in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung tumors
    C L Sabourin
    Division of Environmental Health Sciences, School of Public Health, Ohio State University, Columbus, USA
    Exp Lung Res 24:499-521. 1998
    ..Furthermore, they demonstrate the importance of immunohistochemical studies to examine expression in tissues that contain multiple cell types, such as the lung, and in tumors that by nature are heterogeneous...
  62. doi Molecular modeling of nitrosamines adsorbed on H-ZSM-5 zeolite: an ONIOM study
    Anawat Pinisakul
    Department of Chemistry, Faculty of Science, King Mongkut s University of Technology Thonburi, 126 Pracha utis Rd, Thung kru, Bangkok 10140, Thailand
    J Mol Model 14:1035-41. 2008
    ..Based on amino and imino isomers of nitrosamines, there are two adsorption configurations on the H-ZSM-5 for NA (as NA_a and NA_i), NMA (as NMA_a and NMA_i) and ..
  63. ncbi DNA adduct formation from tobacco-specific N-nitrosamines
    S S Hecht
    University of Minnesota Cancer Center Box 806, Mayo, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Mutat Res 424:127-42. 1999
    Tobacco-specific N-nitrosamines are a group of carcinogens derived from the tobacco alkaloids. They are likely causative factors for cancers of the lung, esophagus, pancreas, and oral cavity in people who use tobacco products...
  64. doi Surveillance of moist snuff: total nicotine, moisture, pH, un-ionized nicotine, and tobacco-specific nitrosamines
    Patricia Richter
    Office on Smoking and Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Nicotine Tob Res 10:1645-52. 2008
    ..Tobacco-specific nitrosamines (TSNAs) are potent carcinogens in smokeless tobacco products, and the pH of the product influences the content ..
  65. ncbi Tobacco-specific nitrosamines and their pyridine-N-glucuronides in the urine of smokers and smokeless tobacco users
    Irina Stepanov
    The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 14:885-91. 2005
    Tobacco-specific nitrosamines are believed to play a significant role as causes of cancer in people who use tobacco products...
  66. ncbi Opisthorchis viverrini infestation and endogenous nitrosamines as risk factors for cholangiocarcinoma in Thailand
    P Srivatanakul
    National Cancer Institute of Thailand, Bangkok
    Int J Cancer 48:821-5. 1991
    ..Small amounts of pre-formed nitrosamines were found in fermented fish and pork food items, which are consumed frequently in the high-risk area for CCA...
  67. ncbi Development of a food database of nitrosamines, heterocyclic amines, and polycyclic aromatic hydrocarbons
    Paula Jakszyn
    Catalan Institute of Oncology, L Hospitalet de Llobregat, Barcelona, Spain
    J Nutr 134:2011-4. 2004
    ..Our objective was to develop a food composition database of nitrates, nitrites, nitrosamines, HA, and PAH...
  68. pmc Subpicogram per milliliter determination of the tobacco-specific carcinogen metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human urine using liquid chromatography-tandem mass spectrometry
    Peyton Jacob
    Division of Clinical Pharmacology, University of California, San Francisco, UCSF Box 1220, San Francisco, California 94143 1220, USA
    Anal Chem 80:8115-21. 2008
    ..The lower limit of quantitation is 0.25 pg/mL for 5-mL urine specimens. Applications to studies of people with a range of different SHS exposure levels is described...
  69. ncbi Survival function of protein kinase C{iota} as a novel nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-activated bad kinase
    Zhaohui Jin
    University of Florida Shands Cancer Center, Department of Medicine, University of Florida, Gainesville, Florida 32610 0232, USA
    J Biol Chem 280:16045-52. 2005
    ....
  70. ncbi Dependence of N-nitrosodimethylamine photodecomposition on the irradiation wavelength: excitation to the s(2) state as a doorway to the dimethylamine radical ground-state chemistry
    Daniel Pelaez
    Department of Physical Chemistry, Faculty of Sciences, University of Malaga, E 29071 Malaga, Spain
    J Org Chem 72:4741-9. 2007
    ....
  71. ncbi Volatile nitrosamines in foods on the Swedish market and estimation of their daily intake
    B G Osterdahl
    Swedish National Food Administration, Uppsala
    Food Addit Contam 5:587-95. 1988
    Foods on the Swedish market in 1980-1986 were analysed for volatile N-nitrosamines using gas chromatography-thermal energy analysis. Detectable levels were found in 474 of the 764 samples analysed...
  72. doi Inhibition by vitamin C of apoptosis induced by N-nitrosamines in HepG2 and HL-60 cells
    Nuria Arranz
    Departamento de Nutricion, Bromatologia y Tecnologia de los Alimentos, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040 Madrid, Spain
    J Appl Toxicol 28:788-96. 2008
    ..Therefore, our findings suggest that inhibition of apoptosis may be one of the mechanisms by which vitamin C exerts its protective effect...
  73. ncbi Rabbit liver microsomal system: study of interaction with two model N-nitrosamines and their metabolism
    M Sulc
    Department of Biochemistry, Faculty of Science, Charles University, Hlavova 2030, 128 43 Prague 2, Czech Republic
    Gen Physiol Biophys 23:423-33. 2004
    ..NDMA does not provide any type of binding spectra with used microsomal systems. Oxidative bio-activation of N-nitrosamines by the microsomal CYP isoforms was measured as formaldehyde formation...
  74. ncbi Formation of N-nitrosamines from eleven disinfection treatments of seven different surface waters
    Yuan Yuan Zhao
    Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, 10 102 Clinical Sciences Building, University of Alberta, Edmonton, Alberta, Canada T6G 2G3
    Environ Sci Technol 42:4857-62. 2008
    Formation of nine N-nitrosamines has been investigated when seven different source waters representing various qualities were each treated with eleven bench-scale disinfection processes, without addition of nitrosamine precursors...
  75. ncbi A germ-line p53 mutation accelerates pulmonary tumorigenesis: p53-independent efficacy of chemopreventive agents green tea or dexamethasone/myo-inositol and chemotherapeutic agents taxol or adriamycin
    Z Zhang
    Department of Pathology, Medical College of Ohio, Toledo 43699, USA
    Cancer Res 60:901-7. 2000
    ..Furthermore, the lung adenomas generated in this model possess mutations in both the K-ras proto-oncogene and the p53 tumor suppressor gene. This model should prove directly useful for chemoprevention and chemotherapy studies...
  76. ncbi Modification by curcumin of mutagenic activation of carcinogenic N-nitrosamines by extrahepatic cytochromes P-450 2B1 and 2E1 in rats
    Yukio Mori
    Institute of Biological Pharmacy, Gifu Pharmaceutical University, 6 1, Mitahora higashi 5 chome, Gifu 502 8585, Japan
    Cancer Sci 97:896-904. 2006
    ..Further, the present findings suggest the potential of curcumin for modification of gastric and intestinal carcinogenesis initiated with NOC...
  77. ncbi Structural features of proteins responsible for resistance of tryptophan residues to nitrosylation
    Tatiana P Suntsova
    Institute of Molecular Genetics, Russian Academy of Sciences, 2 Kurchatov Sq, Moscow, 123182, Russia
    IUBMB Life 54:281-92. 2002
    ..This selection might explain both the resistance of tryptophan residues in proteins to nitrosation and the mechanisms of chemical communication by means of reversible nitrosation of proteins...
  78. pmc Development of estimates of dietary nitrates, nitrites, and nitrosamines for use with the Short Willet Food Frequency Questionnaire
    John S Griesenbeck
    Department of Social and Behavioral Health, School of Rural Public Health, Texas A and M Health Science Center, College Station, TX, USA
    Nutr J 8:16. 2009
    Studies have suggested that nitrates, nitrites, and nitrosamines have an etiologic role in adverse pregnancy outcomes and chronic diseases such as cancer...
  79. ncbi Concomitant presence of N-nitroso and S-nitroso proteins in human plasma
    Tienush Rassaf
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Free Radic Biol Med 33:1590-6. 2002
    ..Our findings may not only have important implications for the transport of NO in vivo, but also for cardiovascular disease diagnostics and the risk assessment of nitrosamine-related carcinogenesis in man...
  80. ncbi Urinary tobacco-specific nitrosamines and 4-aminobiphenyl hemoglobin adducts measured in smokers of either regular or light cigarettes
    John T Bernert
    Division of Laboratory Science, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Nicotine Tob Res 7:729-38. 2005
    ..Thus the concentrations of the carcinogen biomarkers NNAL and 4-ABP in the smokers who regularly smoked light cigarettes were essentially the same as those in the smokers who chose regular cigarettes...
  81. ncbi Excretion of volatile nitrosamines in a rural population in relation to food and drinking water consumption
    P Levallois
    Département de médicine sociale et préventive, Universite Laval, Quebec, Canada
    Food Chem Toxicol 38:1013-9. 2000
    Urinary excretion of volatile nitrosamines was assessed in 59 non-smokers living in a rural county of Québec, Canada. Water and food intakes were measured by means of a 24-hour recall...
  82. ncbi Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines
    Gang Chen
    Cancer Prevention and Control Program, Penn State Cancer Institute, Department of Public Health Sciences, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Pharmacogenet Genomics 18:181-91. 2008
    ....
  83. pmc The influence of repair pathways on the cytotoxicity and mutagenicity induced by the pyridyloxobutylation pathway of tobacco-specific nitrosamines
    Li Li
    Division of Environmental Health Sciences and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 22:1464-72. 2009
    Tobacco-specific nitrosamines, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine, are considered to be human carcinogens...
  84. ncbi Rapid and sensitive gas chromatography-ion-trap tandem mass spectrometry method for the determination of tobacco-specific N-nitrosamines in secondhand smoke
    Mohamad Sleiman
    Indoor Environment Department, Environmental Energy Technologies Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 70 108B, Berkeley, CA 94720, USA
    J Chromatogr A 1216:7899-905. 2009
    Tobacco-specific nitrosamines (TSNAs) are some of the most potent carcinogens in tobacco and cigarette smoke. Accurate quantification of these chemicals is needed to help assess public health risks...
  85. ncbi Cytochrome b5 reductase and cytochrome b5 support the CYP2E1-mediated activation of nitrosamines in a recombinant Ames test
    Vishwesh Mokashi
    Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536 0305, USA
    Arch Biochem Biophys 412:147-52. 2003
    ..Neither cytochrome b(5) reductase nor cytochrome b(5) alone could support CYP2E1 activity. These results demonstrate that the cytochrome b(5) reductase/cytochrome b(5) pathway can support CYP2E1 activity in bacterial cells...
  86. ncbi NNK activates ERK1/2 and CREB/ATF-1 via beta-1-AR and EGFR signaling in human lung adenocarcinoma and small airway epithelial cells
    E Laag
    Experimental Oncology Laboratory, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Int J Cancer 119:1547-52. 2006
    ..Collectively, our data provide evidence, for the first time, that NNK targets ERK1/2 and CREB/ATF-1 proteins via dual signaling involving beta 1-AR and EGFR pathways in PACCs and their putative cells of origin...
  87. ncbi Development of liquid chromatography electrospray ionization tandem mass spectrometry methods for analysis of DNA adducts of formaldehyde and their application to rats treated with N-nitrosodimethylamine or 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
    Mingyao Wang
    University of Minnesota Cancer Center, MMC 806, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Chem Res Toxicol 20:1141-8. 2007
    ..results of this study demonstrate for the first time the presence of formaldehyde DNA adducts in tissues of rats treated with carcinogenic nitrosamines and suggest that these adducts may play a role in cancer induction by these compounds.
  88. ncbi Nongenomic beta estrogen receptors enhance beta1 adrenergic signaling induced by the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human small airway epithelial cells
    Mourad Majidi
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Cancer Res 67:6863-71. 2007
    ..This novel cooperation between beta1AR and ERbeta signaling may contribute to the prominence of lung adenocarcinoma in women...
  89. ncbi Solid-phase microextraction of N-nitrosamines
    Janel E Grebel
    Environmental Science and Engineering Program, UCLA, School of Public Health, Charles E Young Drive South, Box 951772, Los Angeles, CA 90095, USA
    J Chromatogr A 1117:11-8. 2006
    ..The excellent selectivity of SPME in addition to the fast analysis time would make this method ideal for general surveys, wastewater analysis and laboratory studies (e.g. degradation kinetics or formation potential)...
  90. pmc Smoke yields of tobacco-specific nitrosamines in relation to FTC tar level and cigarette manufacturer: analysis of the Massachusetts Benchmark Study
    J E Harris
    Massachusetts Institute of Technology, E52 252F, Cambridge, MA 02139, USA
    Public Health Rep 116:336-43. 2001
    This research assessed the relationship between the deliveries of carcinogenic tobacco-specific nitrosamines (TSNAs) and the Federal Trade Commission (FTC) "tar" ratings of US commercial cigarettes.
  91. pmc Quantitation of pyridyloxobutyl DNA adducts of tobacco-specific nitrosamines in rat tissue DNA by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry
    Yanbin Lao
    Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 19:674-82. 2006
    The tobacco-specific nitrosamines N'-nitrosonornicotine (NNN, 1) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, 2) are potent carcinogens in rodents...
  92. ncbi Simultaneous determination of five tobacco-specific nitrosamines in mainstream cigarette smoke by isotope dilution liquid chromatography/electrospray ionization tandem mass spectrometry
    Weijia Wu
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, Georgia 30341, USA
    Anal Chem 75:4827-32. 2003
    Tobacco-specific nitrosamines (TSNAs) have been previously implicated as a source of carcinogenicity in tobacco and cigarette smoke. Accurate quantification of these chemicals is needed to help assess public health risk...
  93. ncbi NNK-induced hamster lung adenocarcinomas over-express beta2-adrenergic and EGFR signaling pathways
    Hildegard M Schuller
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Lung Cancer 49:35-45. 2005
    ..Taken together, these data point to PKA/CREB as novel targets for the development of cancer therapeutics for PAC patients non-responsive to EGFR-specific tyrosine kinase inhibitors...
  94. doi Determination of tobacco-specific N-nitrosamines in urine of smokers and non-smokers
    Dominique Kavvadias
    Analytisch Biologisches Forschungslabor GmbH, Munich, Germany
    Biomarkers 14:547-53. 2009
    Tobacco-specific N-nitrosamines (TSNA) include 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), N'-nitrosonornicotine (NNN), N'-nitrosoanabasine (NAB) and N'-nitrosoanatabine (NAT) and are found in tobacco and tobacco smoke...
  95. pmc Tobacco specific nitrosamines and potential reduced exposure products for smokers: a preliminary evaluation of Advance
    A B Breland
    Department of Psychology, Virginia Commonwealth University, Richmond, Virginia, USA
    Tob Control 12:317-21. 2003
    ..To develop a method for evaluating the carcinogen delivery of potential reduced exposure products (PREPs) like Advance, a PREP marketed to reduce smokers' exposure to one tobacco specific nitrosamine (TSN), NNK, a potent lung carcinogen...
  96. ncbi Carcinogenic activity of cigarette smoke gas phase and its modulation by beta-carotene and N-acetylcysteine
    Hanspeter Witschi
    Center for Health and the Environment, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
    Toxicol Sci 84:81-7. 2005
    ..that in the filtered smoke the concentrations of polycyclic aromatic hydrocarbons and tobacco smoke specific nitrosamines were reduced to from below 18% to even nondetectable levels of the original values measured in the unfiltered ..
  97. pmc Pre- and post-initiation chemoprevention activity of 2-alkyl/aryl selenazolidine-4(R)-carboxylic acids against tobacco-derived nitrosamine (NNK)-induced lung tumors in the A/J mouse
    Michael R Franklin
    University of Utah, Department of Pharmacology and Toxicology, Salt Lake City, UT 84112, USA
    Chem Biol Interact 168:211-20. 2007
    ..Thus, several 2-aryl/alkyl selenazolidines possess chemopreventive activity against NNK-induced lung tumors, and variously demonstrate pre-initiation and post-initiation efficacy...
  98. pmc Induction of lung lesions in Wistar rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its inhibition by aspirin and phenethyl isothiocyanate
    Bo Ye
    Pathology Department, Basic Medical School, Wuhan University, Dong Hu Road, Wuhan, PR China
    BMC Cancer 7:90. 2007
    ..In the current study, we established a novel lung cancer model in Wistar rats treated with NNK. Using this model, we assessed the effects of two chemopreventive agents, aspirin and phenethyl isothiocyanate (PEITC), on tumor progression...
  99. ncbi Tobacco components stimulate Akt-dependent proliferation and NFkappaB-dependent survival in lung cancer cells
    Junji Tsurutani
    Cancer Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20889, USA
    Carcinogenesis 26:1182-95. 2005
    ..Collectively, these results identify tobacco component-induced, Akt-dependent proliferation and NFkappaB-dependent survival as cellular processes that could underlie the detrimental effects of smoking in cancer patients...
  100. ncbi The chemopreventive effects of orally administered dexamethasone in Strain A/J mice following cessation of smoke exposure
    Hanspeter Witschi
    Center for Health and the Environment, University of California, Davis, California 95616, USA
    Inhal Toxicol 17:119-22. 2005
    ..It is concluded that the dietary intake of dexamethasone against full tobacco smoke might show improved chemopreventive activity when combined with other agents...
  101. ncbi Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice
    Yan Weng
    Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, New York 12201 0509, USA
    Cancer Res 67:7825-32. 2007
    ....

Research Grants84

  1. DRUG INTERACTIONS IN THE ELDERLY
    ILENE RAISFELD; Fiscal Year: 1980
    ..interact with therepautic doses of drugs such as propranolol (Inderal) and hydroxyzine (vistaril) to produce nitrosamines. Many nitrosamines are carcinogenic. This type of drug-drug interaction has not been described previously...
  2. Biomarkers of toxic response to low nicotine cigarette smoke
    Ian Blair; Fiscal Year: 2009
    ..mixture including numerous toxic polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and nitrosamines such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in both the mainstream and sidestream (..
  3. Biomarkers of toxic response to low nicotine cigarette smoke
    Andrew Strasser; Fiscal Year: 2010
    ..mixture including numerous toxic polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and nitrosamines such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in both the mainstream and sidestream (..
  4. ELECTROCATALYTIC STUDIES OF TOXIC POLLUTANT ACTIVATION
    James F Rusling; Fiscal Year: 2011
    ..Examples of bioactivated pollutants include styrene, benzo[a]pyrene, arylamines, and N-nitrosamines. We are developing in vitro biosensor arrays to rapidly measure the ability of metabolites to damage DNA and ..
  5. ELECTROCATALYTIC STUDIES OF TOXIC POLLUTANT ACTIVATION
    James F Rusling; Fiscal Year: 2010
    ..Examples of bioactivated pollutants include styrene, benzo[a]pyrene, arylamines, and N-nitrosamines. We are developing in vitro biosensor arrays to rapidly measure the ability of metabolites to damage DNA and ..
  6. ELECTROCATALYTIC STUDIES OF TOXIC POLLUTANT ACTIVATION
    James Rusling; Fiscal Year: 2009
    ..Examples of bioactivated pollutants include styrene, benzo[a]pyrene, arylamines, and N-nitrosamines. We are developing in vitro biosensor arrays to rapidly measure the ability of metabolites to damage DNA and ..
  7. ALCOHOL METABOLISM--ROLE OF P-450 OXYGENASES
    Minor Coon; Fiscal Year: 1993
    ..is known to metabolize a large variety of foreign compounds, including ethanol and other alcohols, ketones, nitrosamines, and halogenated alkanes, alkanes, and ethers, as well as aromatic compounds, almost no information is yet ..
  8. ALCOHOL METABOLISM--ROLE OF P-450 OXYGENASES
    Minor Coon; Fiscal Year: 1992
    ..is known to metabolize a large variety of foreign compounds, including ethanol and other alcohols, ketones, nitrosamines, and halogenated alkanes, alkanes, and ethers, as well as aromatic compounds, almost no information is yet ..
  9. FORMATION AND METABOLISM OF NITROSAMINES
    Peter Magee; Fiscal Year: 1990
    ..2) To compare the activating and deactiviting metabolic pathways of the nitrosamines in the intact animal in vivo...
  10. ORAL CANCER--DNA POLYMORPHISMS IN CARCINOGEN METABOLISM
    Stephen Schwartz; Fiscal Year: 2001
    ..Oral carcinogens derived from these exposures include N-nitrosamines, polycyclic aromatic hydrocarbons, aromatic amines, heterocyclic amines, and acetaldehyde that are activated ..
  11. ORAL CANCER--DNA POLYMORPHISMS IN CARCINOGEN METABOLISM
    Stephen Schwartz; Fiscal Year: 2000
    ..Oral carcinogens derived from these exposures include N-nitrosamines, polycyclic aromatic hydrocarbons, aromatic amines, heterocyclic amines, and acetaldehyde that are activated ..
  12. ORAL CANCER--DNA POLYMORPHISMS IN CARCINOGEN METABOLISM
    Stephen Schwartz; Fiscal Year: 1999
    ..Oral carcinogens derived from these exposures include N-nitrosamines, polycyclic aromatic hydrocarbons, aromatic amines, heterocyclic amines, and acetaldehyde that are activated ..
  13. Clinical Response to Biomarker Documentation of Child Secondhand Smoke Exposure
    ANNE JOSEPH; Fiscal Year: 2010
    ..Children who see providers in the experimental group will provide a urine sample to test for nitrosamines (a tobacco-specific carcinogen), nicotine and cotinine...
  14. Clinical Response to Biomarker Documentation of Child Secondhand Smoke Exposure
    ANNE JOSEPH; Fiscal Year: 2009
    ..Children who see providers in the experimental group will provide a urine sample to test for nitrosamines (a tobacco-specific carcinogen), nicotine and cotinine...
  15. GENOTOXICITY IN CYP1A2 DEFICIENT TRANSGENIC MICE
    Daniel Nebert; Fiscal Year: 2001
    ..CYP1A2 substrates include environmentally important heterocyclic amines, nitrosamines, aflatoxins, nitrated polycyclic aromatic hydrocarbons, and arylamines such as 4-aminobiphenyl (ABP)...
  16. GENOTOXICITY IN CYP1A2 DEFICIENT TRANSGENIC MICE
    Daniel Nebert; Fiscal Year: 2000
    ..CYP1A2 substrates include environmentally important heterocyclic amines, nitrosamines, aflatoxins, nitrated polycyclic aromatic hydrocarbons, and arylamines such as 4-aminobiphenyl (ABP)...
  17. GENOTOXICITY IN CYP1A2 DEFICIENT TRANSGENIC MICE
    Daniel Nebert; Fiscal Year: 2002
    ..CYP1A2 substrates include environmentally important heterocyclic amines, nitrosamines, aflatoxins, nitrated polycyclic aromatic hydrocarbons, and arylamines such as 4-aminobiphenyl (ABP)...
  18. GENOTOXICITY IN CYP1A2 DEFICIENT TRANSGENIC MICE
    Daniel Nebert; Fiscal Year: 1999
    ..CYP1A2 substrates include environmentally important heterocyclic amines, nitrosamines, aflatoxins, nitrated polycyclic aromatic hydrocarbons, and arylamines such as 4-aminobiphenyl (ABP)...
  19. NITROSAMINE METABOLISM AND ESOPHAGEAL CANCER
    SIDNEY MIRVISH; Fiscal Year: 1992
    ..3. Metabolism of other nitrosamines: We will study the metabolism of 5 methylalkyl and 3 cyclic nitrosamines that induce esophageal cancer in rats ..
  20. CARCINOGENESIS--NITROSAMINE FORMATION AND INHIBITION
    RICHARD LOEPPKY; Fiscal Year: 1992
    ..chemical features which both predispose and serve to block or inhibit the rapid formation of carcinogenic nitrosamines from certain nitrogen compounds both in vivo and in the environment...
  21. Resistance to Nitrosative DNA Damage
    Bernard Weiss; Fiscal Year: 2002
    Description: (provided by applicant): Nitrogen oxides such as nitrite, nitrosamines, and nitric oxide are common environmental and endogenous mutagens that deaminate DNA bases and form alkylating agents. E...
  22. MUTAGENESIS--INTERACTION OF ENVIRONMENTAL CARCINOGENS
    TOM HEI; Fiscal Year: 1999
    ..is to examine the combined mutagenic effects of alpha particles from radon progeny with either tobacco smoke nitrosamines (NNK) or sodium arsenite...
  23. Predictors of Smokeless Tobacco and Dual Use in the US Military
    Robert C Klesges; Fiscal Year: 2010
    ..0% vs. 3.3%). ST use is estimated to be the greatest exogenous source of human exposure to carcinogenic nitrosamines and has been associated with oral and extra-oral cancer as well as cardiovascular and cerebrovascular disease...
  24. Predictors of Smokeless Tobacco and Dual Use in the US Military
    Robert Klesges; Fiscal Year: 2009
    ..0% vs. 3.3%). ST use is estimated to be the greatest exogenous source of human exposure to carcinogenic nitrosamines and has been associated with oral and extra-oral cancer as well as cardiovascular and cerebrovascular disease...
  25. EXPERIMENTAL TOBACCO CARCINOGENESIS
    DIETRICH HOFFMAN; Fiscal Year: 1992
    ..of the development of sensitive quantitative assays for globin- and DNA-adducts with tobacco-specific N- nitrosamines (TSNA) and application to analysis of blood samples, exfoliated oral cells and oral cavity punch biopsy samples ..
  26. FORMATION AND METABOLISM OF N-NITROSO COMPOUNDS
    Peter Magee; Fiscal Year: 1980
    ..The N-nitroso compounds will include nitrosamines, nitrosamides and nitrosamidines as well as methylhydrazines and phenyldimethyl-triazene...
  27. IN VIVO NITROSAMINES AND CANCER IN RENAL FAILURE
    MICHAEL SIMENHOFF; Fiscal Year: 1980
    N-nitroso compounds (nitrosamines) are potent mutagens and carcinogens in experimental animals. Although suggestive, no role has been determined in man...
  28. DEVELOPMENT OF HETEROCYCLIC & SMALL MOLECULE ORGANIC COMBINATORIAL LIBRARIES
    Richard Houghten; Fiscal Year: 2001
    ..of libraries of bicyclic guanidines, cyclic ureas, hydantoins, indole imidazoles, polyamines, hydroxylamines, nitrosamines, etc...
  29. DEVELOPMENT OF HETEROCYCLIC & SMALL MOLECULE ORGANIC COMBINATORIAL LIBRARIES
    Richard Houghten; Fiscal Year: 2002
    ..of libraries of bicyclic guanidines, cyclic ureas, hydantoins, indole imidazoles, polyamines, hydroxylamines, nitrosamines, etc...
  30. DEVELOPMENT OF HETEROCYCLIC & SMALL MOLECULE ORGANIC COMBINATORIAL LIBRARIES
    Richard Houghten; Fiscal Year: 2000
    ..of libraries of bicyclic guanidines, cyclic ureas, hydantoins, indole imidazoles, polyamines, hydroxylamines, nitrosamines, etc...
  31. DEVELOPMENT OF HETEROCYCLIC & SMALL MOLECULE ORGANIC COMBINATORIAL LIBRARIES
    Richard Houghten; Fiscal Year: 1999
    ..of libraries of bicyclic guanidines, cyclic ureas, hydantoins, indole imidazoles, polyamines, hydroxylamines, nitrosamines, etc...
  32. BIOMARKERS OF NNK AND NNN METABOLISM IN HUMANS
    Peter Foiles; Fiscal Year: 1993
    ..Among the most important carcinogens in cigarette smoke and smokeless tobacco are the tobacco specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'- nitrosonornicotine (NNN)...
  33. BIOMARKERS OF NNK AND NNN METABOLISM IN HUMANS
    Peter Foiles; Fiscal Year: 1991
    ..Among the most important carcinogens in cigarette smoke and smokeless tobacco are the tobacco specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'- nitrosonornicotine (NNN)...
  34. EPIDEMIOLOGY OF BARRETTS ESOPHAGUS
    DIANA FARROW; Fiscal Year: 1999
    ..to be tested is that among patients with GERD: 1) cigarette smoking, alcohol consumption and dietary intake of nitrosamines are associated with increased risk of Barrett's esophagus, and that higher dietary intake and serum levels of ..
  35. EPIDEMIOLOGY OF BARRETTS ESOPHAGUS
    Thomas Vaughan; Fiscal Year: 2000
    ..to be tested is that among patients with GERD: 1) cigarette smoking, alcohol consumption and dietary intake of nitrosamines are associated with increased risk of Barrett's esophagus, and that higher dietary intake and serum levels of ..
  36. EXPERIMENTAL TOBACCO CARCINOGENESIS
    DIETRICH HOFFMAN; Fiscal Year: 1993
    ..Five projects are proposed. 1. Study of the activation of tobacco-specific nitrosamines (TSNA) in humans and human risk assessment by measuring adducts of the carcinogenic TSNA, PAH and aromatic ..
  37. DNA Adducts of the Carcinogen Acetaldehyde
    Stephen Hecht; Fiscal Year: 2002
    ..which is far greater than the concentrations of other carcinogens such as benzo[a]pyrene or tobacco-specific nitrosamines, widely assumed to be important as causes of cancer in smokers...
  38. Nitrates, Nitrites, and Nitrosatable Drugs and Risk of Selected Birth Defects
    Jean Brender; Fiscal Year: 2009
    ..Subjects'usual intake of dietary nitrates, nitrites, and nitrosamines will be calculated from the NBDPS food frequency questionnaire...
  39. Nitrates, Nitrites, and Nitrosatable Drugs and Risk of Selected Birth Defects
    JEAN DIANE BRENDER; Fiscal Year: 2010
    ..Subjects'usual intake of dietary nitrates, nitrites, and nitrosamines will be calculated from the NBDPS food frequency questionnaire...
  40. Nitrates, Nitrites, and Nitrosatable Drugs and Risk of Selected Birth Defects
    Jean Brender; Fiscal Year: 2007
    ..Subjects' usual intake of dietary nitrates, nitrites, and nitrosamines will be calculated from the NBDPS food frequency questionnaire...
  41. Nitrates, Nitrites, and Nitrosatable Drugs and Risk of Selected Birth Defects
    Jean Brender; Fiscal Year: 2009
    ..Subjects'usual intake of dietary nitrates, nitrites, and nitrosamines will be calculated from the NBDPS food frequency questionnaire...
  42. CARCINOGENESIS--NITROSAMINE FORMATION AND INHIBITION
    RICHARD LOEPPKY; Fiscal Year: 1999
    ..toward this goal can be achieved through the development of chemistry for 1) the specific destruction of nitrosamines, 2) the specific scavenging of nitrosating agents, and 3) an understanding of the structural features which ..
  43. Snuff carcinogenesis in the oral cavity
    Dietrich Hoffmann; Fiscal Year: 2000
    ..relatively high levels of unprotonated nicotine, and nitrite as precursors for carcinogenic tobacco-specific nitrosamines (TSNA) which are also present at high concentration and continued o be formed during snuff dipping...
  44. Snuff carcinogenesis in the oral cavity
    Dietrich Hoffmann; Fiscal Year: 2001
    ..relatively high levels of unprotonated nicotine, and nitrite as precursors for carcinogenic tobacco-specific nitrosamines (TSNA) which are also present at high concentration and continued o be formed during snuff dipping...
  45. Snuff carcinogenesis in the oral cavity
    DIETRICH HOFFMAN; Fiscal Year: 1999
    ..relatively high levels of unprotonated nicotine, and nitrite as precursors for carcinogenic tobacco-specific nitrosamines (TSNA) which are also present at high concentration and continued o be formed during snuff dipping...
  46. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Polycyclic aromatic hydrocarbons (PAHs), nitrosamines, and N-heterocyclics are present in combustion products, e.g. grilled foods &cigarette smoke...
  47. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Polycyclic aromatic hydrocarbons (PAHs), nitrosamines, and N-heterocyclics are present in combustion products, e.g. grilled foods &cigarette smoke...
  48. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2007
    Polycyclic aromatic hydrocarbons (PAHs), nitrosamines, and N-heterocyclics are present in combustion products, e.g. grilled foods & cigarette smoke...
  49. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2006
    Polycyclic aromatic hydrocarbons (PAHs), nitrosamines, and N-heterocyclics are present in combustion products, e.g. grilled foods & cigarette smoke...
  50. Metabolism of Carcinogenic Tobacco-Specific Nitrosamines
    Stephen S Hecht; Fiscal Year: 2012
    ..These products are accepted causes of oral cavity cancer. Tobacco-specific nitrosamines such as N2-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) are recognized as ..
  51. ROLE OF ETHANOL IN THE ETIOLOGY OF HEAD & NECK CANCER
    G McCoy; Fiscal Year: 1990
    ..of cytochrome P450 induced by ethanol that is believed to participate in the metabolic activation of the N- nitrosamines. The link between ethanol consumption, metabolism, metabolic activity and enhanced tumor incidence will be ..
  52. INTERACTION OF ETHANOL WITH HEPATIC MICROSOMES
    Charles Lieber; Fiscal Year: 1990
    ..with respect to its ability to activate the structurally diverse chemical carcinogens dimethyl- and diethyl- nitrosamines, nitrosopyrolidine and vinylchloride...
  53. INTERACTION OF ETHANOL WITH HEPATIC MICROSOMES
    Charles Lieber; Fiscal Year: 1992
    ..with respect to its ability to activate the structurally diverse chemical carcinogens dimethyl- and diethyl- nitrosamines, nitrosopyrolidine and vinylchloride...
  54. HUMAN LIVER P450 2E1
    Jerome Lasker; Fiscal Year: 1993
    ..Our plan includes assessing whether 2E1 participates in the bioactivation of cocaine and certain nitrosamines (N-nitroso-2,6- dimethylmorpholine and N-nitrosopyrrolidine), agents whose cytotoxicity is enhanced in the ..
  55. Exploring Gene-Environment Factors in Child Brain Tumors
    Beth Mueller; Fiscal Year: 2004
    ..for the following genes: 1) Cytochrome P-450 (CYP) 2E1 and CYP 2D6, coding Phase I enzymes that activate nitrosamines and other chemicals into cancer-causing intermediates; 2) Glutathione S-transferase (GST) (GSTP1, GSTT1, and ..
  56. Exploring Gene-Environment Factors in Child Brain Tumors
    Beth Mueller; Fiscal Year: 2003
    ..for the following genes: 1) Cytochrome P-450 (CYP) 2E1 and CYP 2D6, coding Phase I enzymes that activate nitrosamines and other chemicals into cancer-causing intermediates; 2) Glutathione S-transferase (GST) (GSTP1, GSTT1, and ..
  57. NITRITE AND NITROUS OXIDE PRODUCTION BY BACTERIA
    Tadashi Yoshinari; Fiscal Year: 1980
    ..Nitrite is a precursor of nitrosamines, many of which are known as potent mutagenic and carcinogenic compounds...
  58. METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINES
    Stephen Hecht; Fiscal Year: 1999
    ..S. Tobacco-specific N-nitrosamines are formed from tobacco alkaloids during the curing and processing of tobacco products...
  59. METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINES
    Stephen Hecht; Fiscal Year: 2003
    ..S. Tobacco-specific N-nitrosamines are formed from tobacco alkaloids during the curing and processing of tobacco products...
  60. CO-CARCINOGENIC ACTIVITY OF NITROSAMINE METABOLITES
    Lisa Peterson; Fiscal Year: 2006
    The mechanism of tumor induction by unsymmetric nitrosamines is poorly understood. Alpha-hydroxylation activates these carcinogens to DNA alkylating agents by generating a metabolite that decomposes to an aldehyde and a diazohydroxide...
  61. CO-CARCINOGENIC ACTIVITY OF NITROSAMINE METABOLITES
    Lisa Peterson; Fiscal Year: 2003
    The mechanism of tumor induction by unsymmetric nitrosamines is poorly understood. Alpha-hydroxylation activates these carcinogens to DNA alkylating agents by generating a metabolite that decomposes to an aldehyde and a diazohydroxide...
  62. CO-CARCINOGENIC ACTIVITY OF NITROSAMINE METABOLITES
    Lisa Peterson; Fiscal Year: 2005
    The mechanism of tumor induction by unsymmetric nitrosamines is poorly understood. Alpha-hydroxylation activates these carcinogens to DNA alkylating agents by generating a metabolite that decomposes to an aldehyde and a diazohydroxide...
  63. GENOTOXICITY IN CYP1A2-DEFICIENT TRANSGENIC MICE
    Daniel Nebert; Fiscal Year: 1993
    ..NNK is one of the major tobacco smoke-specific nitrosamines that require CYP1A2 for metabolic activation...
  64. CORE--ORGANIC SYNTHESIS FACILITY
    Shantu Amin; Fiscal Year: 2002
    ..routes for non-radiolabel and radioisotope-labeled polycyclic aromatic hydrocarbons, tobacco- specific N-nitrosamines, and other environmental and nutritional carcinogens, their metabolites, and their DNA adducts...
  65. TOBACCO CARCINOGENESIS AND CHEMOPREVENTION
    Karam El Bayoumy; Fiscal Year: 2002
    ..Besides containing carcinogenic agents such as the tobacco-specific nitrosamines [TSNA, e.g., 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone, (NNK)], the polycyclic aromatic hydrocarbons [e.g...
  66. TOBACCO CARCINOGENESIS AND CHEMOPREVENTION
    Karam El Bayoumy; Fiscal Year: 2001
    ..Besides containing carcinogenic agents such as the tobacco-specific nitrosamines [TSNA, e.g., 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone, (NNK)], the polycyclic aromatic hydrocarbons [e.g...
  67. TOBACCO CARCINOGENESIS AND CHEMOPREVENTION
    Karam El Bayoumy; Fiscal Year: 2005
    ..Besides containing carcinogenic agents such as the tobacco-specific nitrosamines [TSNA, e.g., 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone, (NNK)], the polycyclic aromatic hydrocarbons [e.g...
  68. TOBACCO CARCINOGENESIS AND CHEMOPREVENTION
    Karam El Bayoumy; Fiscal Year: 2003
    ..Besides containing carcinogenic agents such as the tobacco-specific nitrosamines [TSNA, e.g., 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone, (NNK)], the polycyclic aromatic hydrocarbons [e.g...
  69. TOBACCO CARCINOGENESIS AND CHEMOPREVENTION
    Karam El Bayoumy; Fiscal Year: 2004
    ..Besides containing carcinogenic agents such as the tobacco-specific nitrosamines [TSNA, e.g., 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone, (NNK)], the polycyclic aromatic hydrocarbons [e.g...
  70. Metabolism of Carcinogenic Tobacco-Specific Nitrosamines
    Stephen Hecht; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Tobacco-specific nitrosamines are among the most important carcinogens in tobacco products. Extensive analytical studies, carried out in the U.S...
  71. Metabolism of Carcinogenic Tobacco-Specific Nitrosamines
    Stephen Hecht; Fiscal Year: 2005
    Tobacco-specific nitrosamines are among the most important carcinogens in tobacco products. Extensive analytical studies, carried out in the U.S...
  72. Metabolism of Carcinogenic Tobacco-Specific Nitrosamines
    Stephen Hecht; Fiscal Year: 2004
    Tobacco-specific nitrosamines are among the most important carcinogens in tobacco products. Extensive analytical studies, carried out in the U.S...
  73. ACTIVATION AND TRANSPORTATION OF NITROSAMINES
    Barry Gold; Fiscal Year: 1999
    ..In summary, we will be able to relate specific types of DNA damage to the site and type of mutation, and the enzymes that protect from the toxic and/or mutagenic response. ..