nicorandil

Summary

Summary: A derivative of the NIACINAMIDE that is structurally combined with an organic nitrate. It is a potassium-channel opener that causes vasodilatation of arterioles and large coronary arteries. Its nitrate-like properties produce venous vasodilation through stimulation of guanylate cyclase.

Top Publications

  1. pmc Cardioprotective effect of nicorandil, a mitochondrial ATP-sensitive potassium channel opener, prolongs survival in HSPB5 R120G transgenic mice
    Atsushi Sanbe
    Department of Pharmacotherapeutics, School of Pharmacy, Iwate Medical University, Iwate, Japan
    PLoS ONE 6:e18922. 2011
  2. ncbi Nicorandil ameliorates mitochondrial dysfunction in doxorubicin-induced heart failure in rats: possible mechanism of cardioprotection
    Lamiaa A Ahmed
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt Electronic address
    Biochem Pharmacol 86:1301-10. 2013
  3. ncbi Impact of nicorandil to prevent reperfusion injury in patients with acute myocardial infarction: Sigmart Multicenter Angioplasty Revascularization Trial (SMART)
    Satoshi Ota
    First Department of Internal Medicine, Mie University School of Medicine, Japan
    Circ J 70:1099-104. 2006
  4. ncbi Impact of a single intravenous administration of nicorandil before reperfusion in patients with ST-segment-elevation myocardial infarction
    Hideki Ishii
    Department of Cardiology, Nagoya University Graduate of School of Medicine, Nagoya, 466 8550, Japan
    Circulation 112:1284-8. 2005
  5. ncbi Intravenous nicorandil in conjunction with coronary reperfusion therapy is associated with better clinical and functional outcomes in patients with acute myocardial infarction
    Ken Sugimoto
    Division of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan
    Circ J 67:295-300. 2003
  6. pmc Nicorandil attenuates monocrotaline-induced vascular endothelial damage and pulmonary arterial hypertension
    Makoto Sahara
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    PLoS ONE 7:e33367. 2012
  7. ncbi Potassium channel openers protect cardiac mitochondria by attenuating oxidant stress at reoxygenation
    Cevher Ozcan
    Department of Medicine, Molecular Pharmacology, and Experimental Therapeutics, Mayo Clinic, Mayo Foundation, Rochester, Minnesota 55905, USA
    Am J Physiol Heart Circ Physiol 282:H531-9. 2002
  8. ncbi Nicorandil prevents oxidative stress-induced apoptosis in neurons by activating mitochondrial ATP-sensitive potassium channels
    Yasushi Teshima
    Institute of Molecular Cardiobiology, The Johns Hopkins University, Baltimore, MD 21205, USA
    Brain Res 990:45-50. 2003
  9. ncbi Nicorandil enhances cardiac endothelial nitric oxide synthase expression via activation of adenosine triphosphate-sensitive K channel in rat
    S Horinaka
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Tochigi, Japan
    J Cardiovasc Pharmacol 38:200-10. 2001
  10. ncbi Effect of intra-coronary nicorandil administration prior to reperfusion in acute ST segment elevation myocardial infarction
    Han Cheol Lee
    Division of Cardiology, Department of Internal Medicine, College of Medicine, Pusan National University, Pusan National University Hospital, Busan, Republic of Korea
    Circ J 72:1425-9. 2008

Research Grants

  1. Intraocular pressure regulation via ATP-sensitive potassium channels
    Michael F Romero; Fiscal Year: 2013
  2. MYOCARDIAL PERFUSION IN THE HYPERTROPHIED HEART
    ROBERT JAMES BACHE; Fiscal Year: 2010
  3. COLLABORATIVE R01-CARDIAC GRAFTS-FUNCTIONAL ANALYSES
    Robert Kloner; Fiscal Year: 2003
  4. Biologic Ventricular Assist Device
    Robert Kloner; Fiscal Year: 2004
  5. Mesenchymal Stem Cells for Myocardial Infarction
    Robert Kloner; Fiscal Year: 2006
  6. MR Guided Transendocardial Angiogenic Agents
    Maythem Saeed; Fiscal Year: 2007
  7. MECHANISMS OF MYOCARDIAL ISCHEMIC INJURY IN DIABETES
    Judy R Kersten; Fiscal Year: 2010

Detail Information

Publications234 found, 100 shown here

  1. pmc Cardioprotective effect of nicorandil, a mitochondrial ATP-sensitive potassium channel opener, prolongs survival in HSPB5 R120G transgenic mice
    Atsushi Sanbe
    Department of Pharmacotherapeutics, School of Pharmacy, Iwate Medical University, Iwate, Japan
    PLoS ONE 6:e18922. 2011
    ..It is also known that progressive mitochondrial abnormalities and apoptotic cell death occur in the hearts of R120G TG mice. The role of mitochondrial dysfunction and apoptosis in disease progression, however, remains uncertain...
  2. ncbi Nicorandil ameliorates mitochondrial dysfunction in doxorubicin-induced heart failure in rats: possible mechanism of cardioprotection
    Lamiaa A Ahmed
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt Electronic address
    Biochem Pharmacol 86:1301-10. 2013
    ..In the present study, the cardioprotective effect of nicorandil was investigated on hemodynamic alterations and mitochondrial dysfunction induced by cumulative administration ..
  3. ncbi Impact of nicorandil to prevent reperfusion injury in patients with acute myocardial infarction: Sigmart Multicenter Angioplasty Revascularization Trial (SMART)
    Satoshi Ota
    First Department of Internal Medicine, Mie University School of Medicine, Japan
    Circ J 70:1099-104. 2006
    b>Nicorandil in conjunction with percutaneous coronary intervention (PCI) has been reported to reduce reperfusion injury events and improve cardiac function in patients with acute myocardial infarction (AMI)...
  4. ncbi Impact of a single intravenous administration of nicorandil before reperfusion in patients with ST-segment-elevation myocardial infarction
    Hideki Ishii
    Department of Cardiology, Nagoya University Graduate of School of Medicine, Nagoya, 466 8550, Japan
    Circulation 112:1284-8. 2005
    Intravenous nicorandil, a hybrid compound of ATP-sensitive potassium channel opener and nitric oxide donor, has been reported to ameliorate early functional and clinical problems in patients with acute myocardial infarction...
  5. ncbi Intravenous nicorandil in conjunction with coronary reperfusion therapy is associated with better clinical and functional outcomes in patients with acute myocardial infarction
    Ken Sugimoto
    Division of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan
    Circ J 67:295-300. 2003
    The aim of this retrospective study was to assess whether intravenous nicorandil, a hybrid of NO and a KATP channel opener, in conjunction with percutaneous coronary intervention (PCI) improves the long-term prognosis in patients with ..
  6. pmc Nicorandil attenuates monocrotaline-induced vascular endothelial damage and pulmonary arterial hypertension
    Makoto Sahara
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    PLoS ONE 7:e33367. 2012
    An antianginal K(ATP) channel opener nicorandil has various beneficial effects on cardiovascular systems; however, its effects on pulmonary vasculature under pulmonary arterial hypertension (PAH) have not yet been elucidated...
  7. ncbi Potassium channel openers protect cardiac mitochondria by attenuating oxidant stress at reoxygenation
    Cevher Ozcan
    Department of Medicine, Molecular Pharmacology, and Experimental Therapeutics, Mayo Clinic, Mayo Foundation, Rochester, Minnesota 55905, USA
    Am J Physiol Heart Circ Physiol 282:H531-9. 2002
    ..The protective effect of diazoxide was reproduced by the structurally distinct K(+) channel opener nicorandil and antagonized by 5-hydroxydecanoic acid, a short-chain fatty acid derivative and presumed blocker of ..
  8. ncbi Nicorandil prevents oxidative stress-induced apoptosis in neurons by activating mitochondrial ATP-sensitive potassium channels
    Yasushi Teshima
    Institute of Molecular Cardiobiology, The Johns Hopkins University, Baltimore, MD 21205, USA
    Brain Res 990:45-50. 2003
    b>Nicorandil, a clinically useful drug for the treatment of ischemic heart disease, has an anti-apoptotic effect in cardiomyocytes, and activation of mitochondrial ATP-sensitive potassium (mitoKATP) channels underlies this effect...
  9. ncbi Nicorandil enhances cardiac endothelial nitric oxide synthase expression via activation of adenosine triphosphate-sensitive K channel in rat
    S Horinaka
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Tochigi, Japan
    J Cardiovasc Pharmacol 38:200-10. 2001
    ..Our aim was to assess whether pharmacologic activation of the K(ATP) channel by nicorandil contributes to endothelial nitric oxide synthase (eNOS) levels...
  10. ncbi Effect of intra-coronary nicorandil administration prior to reperfusion in acute ST segment elevation myocardial infarction
    Han Cheol Lee
    Division of Cardiology, Department of Internal Medicine, College of Medicine, Pusan National University, Pusan National University Hospital, Busan, Republic of Korea
    Circ J 72:1425-9. 2008
    Intravenous nicorandil infusion with percutaneous coronary intervention (PCI) has been reported to reduce reperfusion injury events and improve cardiac function in patients with acute myocardial infarction (MI)...
  11. ncbi Nicorandil preserves mitochondrial function during ischemia in perfused rat heart
    Takeshi Iwai
    Department of Pharmacology, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Eur J Pharmacol 446:119-27. 2002
    A possible mechanism for the action of nicorandil on the improvement of energy metabolism of ischemic/reperfused hearts was examined. Perfused rat hearts were subjected to 35-min ischemia/60-min reperfusion...
  12. ncbi Comparison of the effects of nitroprusside versus nicorandil on the slow/no-reflow phenomenon during coronary interventions for acute myocardial infarction
    Renpei Kobatake
    Department of Cardiology, Japanese Red Cross Okayama Hospital, 2 1 1 Aoe Kita ku, Okayama 700 8607, Japan
    Heart Vessels 26:379-84. 2011
    ..We compared the acute, in-hospital and long-term (1 year) effects of nitroprusside (NTP) with those of nicorandil (NC) on the slow/no-reflow phenomenon...
  13. ncbi Continuous administration of nicorandil decreases QT dispersion during the chronic phase of acute myocardial infarction
    Tadasu Akagi
    Department of Cardiology, Rakuwakai Otowa Hospital, Kyoto, Japan
    Int Heart J 47:351-61. 2006
    We previously reported that continuous intravenous (IV) administration of nicorandil (NIC) inhibits QT dispersion (QTd)...
  14. ncbi Nicorandil administration shows cardioprotective effects in patients with poor TIMI and collateral flow as well as good flow after AMI
    Takuji Toyama
    Gunma Prefectural Cardiovascular Center, Gunma University School of Medicine
    Ann Nucl Med 20:277-85. 2006
    b>Nicorandil (NCR) has been reported to have cardioprotective effects in patients with AMI. And collateral flow and TIMI flow are also important determinants of final salvaged myocardium in patients with AMI...
  15. ncbi Effects of intravenous nicorandil before reperfusion for acute myocardial infarction in patients with stress hyperglycemia
    Hideki Ishii
    Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, 466 8550, Japan
    Diabetes Care 29:202-6. 2006
    ..We aimed to assess effects of intravenous nicorandil administered before reperfusion on AMI patients with stress hyperglycemia.
  16. ncbi Nicorandil and leukocyte activation
    Takanori Yasu
    Department of Integrated Medicine I, Omiya Medical Center, Jichi Medical School, Saitama, Japan
    J Cardiovasc Pharmacol 40:684-92. 2002
    b>Nicorandil, a hybrid compound of an ATP-sensitive potassium (KATP ) channel opener and a nitric oxide donor, has been reported to preserve microvascular integrity in patients with reperfused myocardial infarction...
  17. ncbi Hypoxia-reoxygenation, St. Thomas cardioplegic solution, and nicorandil on endothelium-derived hyperpolarizing factor in coronary microarteries
    Ying Ying Dong
    Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China
    Ann Thorac Surg 80:1803-11. 2005
    ..Thomas solution under clinically relevant temperatures and effects of nicorandil on endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxation in porcine coronary microarteries.
  18. ncbi Effects of nicorandil in neuroprotective activation of PI3K/AKT pathways in a cellular model of Alzheimer's disease
    Jingjing Kong
    Department of Neurology, First Affiliated Hospital of China Medical University, Shenyang, China
    Eur Neurol 70:233-41. 2013
    b>Nicorandil, an ATP-sensitive potassium (KATP) channel opener, is known to have protective effects on ischemic injury in heart and brain...
  19. ncbi Gastroprotective effect of nicorandil in indomethacin and alcohol-induced acute ulcers
    M A El-Moselhy
    Department of Pharmacology, Minia University, Minia, Egypt
    Appl Biochem Biotechnol 152:449-59. 2009
    ..We aim to study a possible benefit of a common nitrogen oxide donor, anti-anginal drug, nicorandil [N-(2-hydroxyethyl) nicotinamide nitrate ester], in managing acute gastric ulcers through studying its effect on ..
  20. ncbi Intravenous administration of nicorandil immediately before percutaneous coronary intervention can prevent slow coronary flow phenomenon
    Yusuke Kawai
    Department of Cardiology, National Hospital Organization Okayama Medical Center, Tamasu, Okayama, Japan
    Eur Heart J 30:765-72. 2009
    To determine the effect of intravenous administration of nicorandil on slow coronary flow (SCF) phenomenon in patients undergoing percutaneous coronary intervention (PCI).
  21. ncbi Comparison between nicorandil and magnesium as an adjunct cardioprotective agent to percutaneous coronary intervention in acute anterior myocardial infarction
    Mizuo Nameki
    Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Japan
    Circ J 68:192-7. 2004
    It has been reported that both nicorandil and magnesium have a cardioprotective effect in experimental ischemia - reperfusion models...
  22. ncbi Nicorandil inhibits the release of TNFalpha from a lymphocyte cell line and peripheral blood lymphocytes
    X M Wei
    Inflammation Research Unit, School of Pathology, Faculty of Medicine, UNSW and Department of Respiratory Medicine, Prince of Wales Hospital, NSW 2031, Randwick, Australia
    Int Immunopharmacol 3:1581-8. 2003
    ..This study determined whether nicorandil, a potassium channel opener, and nitric oxide (NO) donor could inhibit the release of tumour necrosis factor ..
  23. pmc Effects of chronic treatment with a low dose of nicorandil on the function of the rat aorta during ageing
    Stéphanie Raveaud
    Laboratory of Vascular Physiopathologies Cellular Interactions, Signalling and Ageing, Joseph Fourier University, Grenoble, F 38041, France
    Clin Exp Pharmacol Physiol 36:988-94. 2009
    ..b>Nicorandil, a K(ATP) channel opener, nitric oxide (NO) donor and anti-oxidant, induces vasodilation, decreases blood ..
  24. ncbi Nicorandil improves glomerular injury in rats with mesangioproliferative glomerulonephritis via inhibition of proproliferative and profibrotic growth factors
    Hirokazu Sudo
    Product Research Department, Chugai Pharmaceutical Co, Ltd, Japan
    J Pharmacol Sci 111:53-9. 2009
    ..b>Nicorandil, a therapeutic drug for angina and acute heart failure, have been reported to show antiproliferative activity in ..
  25. ncbi High index of microcirculatory resistance level after successful primary percutaneous coronary intervention can be improved by intracoronary administration of nicorandil
    Noritoshi Ito
    Critical and Cardiovascular Care Unit, Osaka Saiseikai Senri Hospital, Suita, Japan
    Circ J 74:909-15. 2010
    ..We hypothesized that intracoronary administration of nicorandil can improve IMR after successful primary PCI in patients with ST-segment elevation myocardial infarction (STEMI).
  26. ncbi Comparative study of nicorandil and a spasmolytic cocktail in preventing radial artery spasm during transradial coronary angiography
    Seong Hwan Kim
    Division of Cardiology, Department of Internal Medicine, Hallym University Medical Center, 94 200, Yeongdeungpo dong, Yeongdeungpo gu, 150 030, Seoul, Republic of Korea
    Int J Cardiol 120:325-30. 2007
    ..This study was designed to compare the spasmolytic effect between nicorandil and a cocktail during transradial coronary angiography.
  27. ncbi Nicorandil affords cardioprotection in patients with acute myocardial infarction treated with primary percutaneous transluminal coronary angioplasty: assessment with thallium-201/iodine-123 BMIPP dual SPECT
    S Fukuzawa
    Division of Cardiology, Funabashi Municipal Medical Center, Chiba, Japan
    J Nucl Cardiol 7:447-53. 2000
    It has been reported that nicorandil restores blood flow to reperfused myocardium in patients with acute myocardial infarction. However, whether nicorandil might decrease infarct size remains unclear...
  28. ncbi Human atrial natriuretic peptide and nicorandil as adjuncts to reperfusion treatment for acute myocardial infarction (J-WIND): two randomised trials
    Masafumi Kitakaze
    Cardiovascular Division of Medicine, National Cardiovascular Centre, Suita, Osaka, Japan
    Lancet 370:1483-93. 2007
    Patients who have acute myocardial infarction remain at major risk of cardiovascular events. We aimed to assess the effects of either human atrial natriuretic peptide or nicorandil on infarct size and cardiovascular outcome.
  29. ncbi Effect of angiotensin-converting enzyme inhibitors and nitroxy groups on human coronary resistance vessels in vitro
    K Takahashi
    First Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    J Cardiovasc Pharmacol 36:417-22. 2000
    ..Nitroglycerin did not change the vasoresponse, whereas nicorandil induced a concentration-dependent vasodilation that was not affected by methylene blue, but was markedly ..
  30. ncbi Intravenous nicorandil can preserve microvascular integrity and myocardial viability in patients with reperfused anterior wall myocardial infarction
    H Ito
    Division of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan
    J Am Coll Cardiol 33:654-60. 1999
    We assessed whether the intravenous administration of nicorandil, an adenosine triphosphate (ATP)-sensitive K+ channel opener, exerts beneficial effect on microvascular function and functional and clinical outcomes in patients with acute ..
  31. ncbi Effect of intravenous nicorandil and preexisting angina pectoris on short- and long-term outcomes in patients with a first ST-segment elevation acute myocardial infarction
    Hideki Ishii
    Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Am J Cardiol 99:1203-7. 2007
    ..that prodromal angina before acute myocardial infarction (AMI) is associated with better outcomes and that nicorandil has cardioprotective effects on ischemic hearts...
  32. ncbi Paclitaxel-induced endothelial dysfunction in living rats is prevented by nicorandil via reduction of oxidative stress
    Ken Ichi Serizawa
    Product Research Department, Chugai Pharmaceutical Co, Ltd, Japan
    J Pharmacol Sci 119:349-58. 2012
    ..Protective effects of nicorandil on paclitaxel-induced endothelial dysfunction by examining flow-mediated dilation (FMD) were investigated in ..
  33. ncbi Effects of nicorandil on the reduction of BNP levels in patients with chronic kidney disease
    Tomonori Kimura
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, B6, 2 2 Yamada oka, Suita, Osaka 585 0871, Japan
    Clin Exp Nephrol 15:854-60. 2011
    ..We examined whether nicorandil, a hybrid nitrate and adenosine triphosphate-sensitive potassium channel opener, could improve a biomarker and ..
  34. ncbi Nicorandil suppresses the increases in plasma level of matrix metalloproteinase activity and attenuates left ventricular remodeling in patients with acute myocardial infarction
    Takayuki Fujiwara
    Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Heart Vessels 22:303-9. 2007
    b>Nicorandil, a hybrid KATP channel opener and nicotinamide nitrate, reduces no-reflow phenomenon and improves cardiac function in patients with acute myocardial infarction (AMI)...
  35. ncbi Cardioprotective effects of nicorandil, a mitochondrial potassium channel opener against doxorubicin-induced cardiotoxicity in rats
    Ihab T Abdel-Raheem
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt
    Basic Clin Pharmacol Toxicol 113:158-66. 2013
    ..b>Nicorandil, a mitochondrial ATP-dependent potassium (KATP ) channel opener, was reported to be cardioprotective on ..
  36. ncbi Nicorandil ameliorates hypertension-related bladder dysfunction in the rat
    Motoaki Saito
    Division of Molecular Pharmacology, Tottori University School of Medicine, Yonago, Japan
    Neurourol Urodyn 31:695-701. 2012
    There is increasing evidence that ischemia is one of the main etiology in overactive bladder (OAB), and that nicorandil prevents OAB...
  37. pmc Nicorandil ameliorates ischaemia-reperfusion injury in the rat kidney
    Shogo Shimizu
    Division of Molecular Pharmacology, Tottori University School of Medicine, Yonago, Japan
    Br J Pharmacol 163:272-82. 2011
    b>Nicorandil, an ATP-sensitive potassium (K(ATP) ) channel opener and nitric oxide donor, is used in the treatment of angina and acute heart failure...
  38. ncbi Vasorelaxant properties of nicorandil on human radial artery
    J R Sadaba
    Department of Cardio Thoracic Surgery, Yorkshire Heart Centre, The General Infirmary, Leeds, UK
    Eur J Cardiothorac Surg 17:319-24. 2000
    ..Because a large component of vasospasm was resistant to Ca(2+) antagonists, the second aim was to test if a different class of vasodilator, nicorandil, might relax the residual tone.
  39. ncbi Left ventricular remodeling after infarction: sequential MR imaging with oral nicorandil therapy in rat model
    Maythem Saeed
    Department of Radiology, University of California, San Francisco, 505 Parnassus Ave, Rm L 308, 94143 0628, USA
    Radiology 224:830-7. 2002
    To use magnetic resonance (MR) imaging in quantification of the short- and long-term effects of therapy with orally administered nicorandil on left ventricular (LV) geometry and function independent of infarction size.
  40. ncbi Effect of nicorandil on left ventricular end-diastolic pressure during exercise in patients with hypertrophic cardiomyopathy
    Hideo Izawa
    Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Eur Heart J 24:1340-8. 2003
    ..The effects of nicorandil on left ventricular end-diastolic pressure during exercise were examined in patients with this condition.
  41. ncbi Opening of the adenosine triphosphate-sensitive potassium channel attenuates cardiac remodeling induced by long-term inhibition of nitric oxide synthesis: role of 70-kDa S6 kinase and extracellular signal-regulated kinase
    Shoji Sanada
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Japan
    J Am Coll Cardiol 40:991-7. 2002
    ....
  42. ncbi Pharmacological preconditioning with nicorandil and pioglitazone attenuates myocardial ischemia/reperfusion injury in rats
    Lamiaa A Ahmed
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Egypt
    Eur J Pharmacol 663:51-8. 2011
    The present investigation was designed to study the cardioprotective effects of nicorandil and pioglitazone preconditioning in myocardial ischemia/reperfusion-induced hemodynamic, biochemical and histological changes in rats...
  43. ncbi Nicorandil inhibits oxidative stress-induced apoptosis in cardiac myocytes through activation of mitochondrial ATP-sensitive potassium channels and a nitrate-like effect
    Kohzo Nagata
    Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Mol Cell Cardiol 35:1505-12. 2003
    The anti-anginal drug nicorandil has been shown to inhibit apoptosis by activating mitochondrial ATP-sensitive potassium (K(ATP)) channels...
  44. ncbi Effect of nicorandil on proteinuria in well controlled hypertensive patients
    Tsung Ming Lee
    Department of Medicine, Cardiology Section, Taipei Medical University and Chi Mei Medical Center, Tainan, Taiwan
    J Hypertens 27:618-25. 2009
    Proteinuria is an important risk factor for cardiovascular and renal morbidity and mortality. The effect of nicorandil on proteinuria in hypertensive patients well controlled by antihypertensive agents containing a low dose of valsartan ..
  45. ncbi Effect of intracoronary nicorandil administration on preventing no-reflow/slow flow phenomenon during rotational atherectomy
    Akiyoshi Tsubokawa
    Department of Cardiovascular Medicine, Takeda General Hospital, Kyoto, Japan
    Circ J 66:1119-23. 2002
    ..Recent clinical studies have demonstrated the beneficial effects of nicorandil, an adenosine triphosphate (ATP)-sensitive potassium channel opener, on no-reflow in patients with acute ..
  46. pmc Effects of KRN2391, nicorandil and diltiazem on the changes in the electrocardiogram caused by endothelin-1 in anaesthetized rats
    K Harada
    Pharmaceutical Research Laboratory, Kirin Brewery Co Ltd, Gunma, Japan
    Br J Pharmacol 109:679-84. 1993
    ..caused by endothelin-1 (ET-1) was studied in anaesthetized rats and compared with the effects of nicorandil and diltiazem...
  47. ncbi Nicorandil treatment in patients with acute myocardial infarction: a meta-analysis
    Katsuomi Iwakura
    Cardiovascular Center, Sakurabashi Watanabe Hospital, Osaka, Japan
    Circ J 73:925-31. 2009
    It is controversial as to whether nicorandil would have cardioprotective effects in patients with acute myocardial infarction (AMI) who are undergoing reperfusion therapy...
  48. ncbi Nicorandil protects cardiac mitochondria against permeability transition induced by ischemia-reperfusion
    Raquel S Carreira
    Basic Research Unit in Cardiology, Cardiology Department, Coimbra University Hospital, Azinhaga de Santa Comba, Celas, 3000 548, Coimbra, Portugal
    J Bioenerg Biomembr 40:95-102. 2008
    ..We aimed to analyze the effects of nicorandil, an ATP-sensitive potassium channel agonist and vasodilator, on mitochondrial function of rat hearts and cardiac ..
  49. ncbi Nicorandil inhibits serum starvation-induced apoptosis in vascular endothelial cells
    Taro Date
    Division of Cardiology, Department of Internal Medicine, Jikei University School of Medicine, Nishi Shinbashi, Tokyo, Japan
    J Cardiovasc Pharmacol 46:721-6. 2005
    The Impact Of Nicorandil in Angina (IONA) randomized trial showed a significant reduction in coronary events, in patients with stable angina treated with a KATP channel opener, nicorandil...
  50. pmc Nicorandil normalizes prolonged repolarisation in the first transgenic rabbit model with Long-QT syndrome 1 both in vitro and in vivo
    Jürgen Biermann
    Department of Cardiology and Angiology, University Hospital of Freiburg, Freiburg, Germany
    Eur J Pharmacol 650:309-16. 2011
    ..We evaluated for the first time the effect of nicorandil, an opener of ATP-sensitive potassium channels, and of isoproterenol on cardiac action potential duration and ..
  51. ncbi Nicorandil enhances the effect of endothelial nitric oxide under hypoxia-reoxygenation: role of the KATP channel
    Masamichi Tajima
    Division of Pharmacology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Sakado, Saitama 350 0283, Japan
    Eur J Pharmacol 579:86-92. 2008
    b>Nicorandil increased the anti-platelet aggregation activity of endothelial cells when endothelial cells were exposed to hypoxia-reoxygenation conditions. However, nicorandil (0.1-10 muM) did not inhibit platelet aggregation directly...
  52. pmc Nicorandil prevents endothelial dysfunction due to antioxidative effects via normalisation of NADPH oxidase and nitric oxide synthase in streptozotocin diabetic rats
    Ken Ichi Serizawa
    Product Research Department, Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412 8513 Japan
    Cardiovasc Diabetol 10:105. 2011
    b>Nicorandil, an anti-angina agent, reportedly improves outcomes even in angina patients with diabetes. However, the precise mechanism underlying the beneficial effect of nicorandil on diabetic patients has not been examined...
  53. ncbi Effects of nicorandil on monocrotaline-induced pulmonary arterial hypertension in rats
    Minoru Hongo
    Department of Cardiovascular Medicine, Shinshu University School of Health Sciences, Matsumoto, Japan
    J Cardiovasc Pharmacol 46:452-8. 2005
    We investigated whether nicorandil might prevent and reverse monocrotaline (MCT)-induced pulmonary arterial hypertension. Rats were injected with 50 mg/kg of MCT subcutaneously and randomized to either 7...
  54. ncbi Mitochondrial K ATP channel activation is important in the antiarrhythmic and cardioprotective effects of non-hypotensive doses of nicorandil and cromakalim during ischemia/reperfusion: a study in an intact anesthetized rabbit model
    Biswadeep Das
    Department of Pharmacology, Kasturba Medical College, Manipal, Karnataka 576119, India
    Pharmacol Res 47:447-61. 2003
    ..the effects of administration of non-hypotensive doses of ATP-sensitive K(+) channel (K(ATP)) openers (nicorandil and cromakalim), a specific mitochondrial K(ATP) channel blocker (5-hydroxydecanoate (5-HD)) and a specific ..
  55. ncbi Synergistic effect of Nicorandil and Amlodipine on tissue defense system during experimental myocardial infarction in rats
    Venkatachalem Sathish
    Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus, Chennai, India
    Mol Cell Biochem 243:133-8. 2003
    The synergistic protective effect of Nicorandil (K(ATP) channel opener) and Amlodipine (calcium channel blocker) on heart tissue antioxidant defense system and lipid profile were examined on isoproterenol induced myocardial infarction in ..
  56. ncbi Effect of ATP-sensitive potassium channel agonists on ventricular remodeling in healed rat infarcts
    Tsung Ming Lee
    Cardiology Section, Department of Medicine, Taipei Medical University and Chi Mei Medical Center, Tainan, Taiwan
    J Am Coll Cardiol 51:1309-18. 2008
    ..The purpose of this study was to determine whether ATP-sensitive potassium (K(ATP)) channel agonists exert a beneficial effect on the structural, functional, and molecular features of the remodeling heart in infarcted rats...
  57. ncbi Antiapoptotic effect of nicorandil mediated by mitochondrial atp-sensitive potassium channels in cultured cardiac myocytes
    Masaharu Akao
    Institute of Molecular Cardiobiology, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Am Coll Cardiol 40:803-10. 2002
    We examined whether nicorandil, a clinically useful drug for the treatment of ischemic syndromes, inhibits myocardial apoptosis.
  58. ncbi Effects of long-term nicorandil administration on endothelial function, inflammation, and oxidative stress in patients without coronary artery disease
    Yutaka Ishibashi
    Division of Cardiovascular Medicine, Department of Internal Medicine, Shimane University Faculty of Medicine, Shimane, Japan
    J Cardiovasc Pharmacol 51:311-6. 2008
    Long-term administration of nicorandil has been shown to improve outcomes through cardioprotective effects in patients with coronary artery disease...
  59. ncbi Nicorandil protects against lethal ischemic ventricular arrhythmias and up-regulates endothelial nitric oxide synthase expression and sulfonylurea receptor 2 mRNA in conscious rats with acute myocardial infarction
    Shigeo Horinaka
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi, 321 0293, Japan
    Cardiovasc Drugs Ther 18:13-22. 2004
    b>Nicorandil is an adenosine triphosphate sensitive K (K-ATP) channel opener and a nitric oxide donor. K-ATP channels and nitric oxide are important factors in ischemic preconditioning, which in turn suppresses reperfusion arrhythmias...
  60. ncbi Nicorandil reduces myocardial no-reflow by protection of endothelial function via the activation of KATP channel
    Jing lin Zhao
    Department of Cardiology, Cardiovascular Institute and Fu Wai Heart Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Bei Li Shi Road 167, West City District, Beijing, 100037, China
    Clin Chim Acta 374:100-5. 2006
    It has been found that nicorandil can attenuate myocardial no-reflow. However, the exact cause of this beneficial effect has remained unclear...
  61. ncbi Effects of the long-term administration of nicorandil on vascular endothelial function and the progression of arteriosclerosis
    Michihito Sekiya
    Department of Cardiology, Ehime National Hospital, Ehime, Japan
    J Cardiovasc Pharmacol 46:63-7. 2005
    This study compared the effects of long-term administration of nicorandil and isosorbide dinitrate (ISDN) on vascular endothelial function and the progression of arteriosclerosis...
  62. ncbi Nicorandil promotes myocardial capillary and arteriolar growth in the failing heart of Dahl salt-sensitive hypertensive rats
    Jinglan Xu
    Department of Cardiovascular Genome Science, Nagoya University School of Medicine, Nagoya 466 8550, Japan
    Hypertension 46:719-24. 2005
    ..b>Nicorandil, an activator of ATP-sensitive potassium channels with a nitrate-like action, is a potent vasodilator...
  63. ncbi Cardiovascular and pharmacokinetic interactions between nicorandil and adjunctive propranolol, atenolol or diltiazem in conscious dogs
    S J Humphrey
    Pharmacology Department, Pharmacia and Upjohn, Inc, Kalamazoo, Michigan, USA
    Methods Find Exp Clin Pharmacol 20:779-91. 1998
    In support of clinical antianginal studies, the vasodilator nicorandil (NIC) was combined with the beta-adrenergic receptor antagonists propranolol (PRO) and atenolol (ATN) and with the calcium channel blocker diltiazem (DTZ) to determine ..
  64. ncbi Nicorandil but not ISDN upregulates endothelial nitric oxide synthase expression, preventing left ventricular remodeling and degradation of cardiac function in Dahl salt-sensitive hypertensive rats with congestive heart failure
    Shigeo Horinaka
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi, 321 0293, Japan
    J Cardiovasc Pharmacol 47:629-35. 2006
    ..b>Nicorandil (NIC) enhanced ecNOS by activating Adenosine triphosphate-sensitive potassium channels (K-ATP channels) in the ..
  65. ncbi Mitochondrial K(ATP) channel opener prevents ischemia-reperfusion injury in rat liver
    S Hai
    Department of Hepato Biliary Pancreatic Surgery, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Transplant Proc 37:428-31. 2005
    ..The aim of this study was to determine the effects of the mitochondrial K(ATP) channel opener, nicorandil, on ischemia-reperfusion injury in the rat liver...
  66. ncbi Nicorandil protects ATP-sensitive potassium channels against oxidation-induced dysfunction in cardiomyocytes of aging rats
    Stéphanie Raveaud
    Universite Joseph Fourier, Grenoble, France
    Biogerontology 10:537-47. 2009
    ..b>Nicorandil, a K(ATP) channel opener, nitric oxide donor and antioxidant, is used as a treatment of angina pectoris and ..
  67. ncbi Nicorandil: albuterol-like or cromolyn-like?
    W Michael Alberts
    Crit Care Med 31:651-2. 2003
  68. ncbi Nicorandil improves cardiac function and clinical outcome in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention: role of inhibitory effect on reactive oxygen species formation
    Hirotsugu Ono
    The Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
    Am Heart J 148:E15. 2004
    ..We examined the effect of nicorandil, a hybrid of K(ATP) channel opener and nicotinamide nitrate, on reactive oxygen species (ROS) formation and ..
  69. ncbi Nicorandil improves diabetes and rat islet beta-cell damage induced by streptozotocin in vivo and in vitro
    K Kasono
    Department of Endocrinology and Metabolism, Jichi Medical School, Omiya Medical Center, Saitama, Japan
    Eur J Endocrinol 151:277-85. 2004
    N-(2-hydroxyethyl)-nicotinamide nitrate (nicorandil) is a unique anti-anginal agent, reported to act as both an ATP-sensitive K(+) channel opener (PCO) and a nitric oxide donor. It also has an anti-oxidant action...
  70. ncbi Nicorandil inhibits angiotensin-II-induced proliferation of cultured rat cardiac fibroblasts
    Jer Young Liou
    Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan, ROC
    Pharmacology 87:144-51. 2011
    b>Nicorandil, an ATP-sensitive potassium (K(ATP)) channel opener, nitric oxide (NO) donor and antioxidant, was shown to exert a variety of pharmacological effects including cardioprotective properties...
  71. ncbi Effects of nicorandil on cardiovascular events in patients with coronary artery disease in the Japanese Coronary Artery Disease (JCAD) study
    Shigeo Horinaka
    Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University, Tochigi, Japan
    Circ J 74:503-9. 2010
    b>Nicorandil has cardioprotective effects in the ischemic myocardium, mimicking ischemic preconditioning, and is thus expected to improve the prognosis of ischemic heart disease (IHD)...
  72. ncbi Nicorandil attenuates FeCl(3)-induced thrombus formation through the inhibition of reactive oxygen species production
    Yu Eguchi
    Department of Physiology, Tokai University School of Medicine, Isehara, Japan
    Circ J 73:554-61. 2009
    Although nicorandil has a number of beneficial cardiovascular actions, its effects on endothelial cells in the context of thrombosis have not been elucidated.
  73. ncbi New insights in the treatment strategy for pulmonary arterial hypertension
    Makoto Sahara
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Cardiovasc Drugs Ther 20:377-86. 2006
    ..Considering these circumstances, it is necessary to develop additional novel therapeutic approaches that target the various components of this multifactorial disease...
  74. ncbi Nicorandil attenuates NF-kappaB activation, adhesion molecule expression, and cytokine production in patients with coronary artery bypass surgery
    Takae Kawamura
    Department of Anesthesiology, Sendai Medical Center, Miyagi, Japan
    Shock 24:103-8. 2005
    b>Nicorandil (NCR), a KATP channel opener, has been reported to preserve microvascular integrity in patients with reperfused myocardial infarction...
  75. ncbi p38-MAPK is involved in restoration of the lost protection of preconditioning by nicorandil in vivo
    Efstathios K Iliodromitis
    2nd University Department of Cardiology, Medical School, Attikon General Hospital, University of Athens, Athens, 124 62, Greece
    Eur J Pharmacol 579:289-97. 2008
    b>Nicorandil, a selective mitochondrial K(ATP) channel opener, reinstates the waned protection after multiple cycles of preconditioning...
  76. ncbi Nicorandil regulates Bcl-2 family proteins and protects cardiac myocytes against hypoxia-induced apoptosis
    Susumu Nishikawa
    Department of Cardiology and Vascular Regenerative Medicine, Kyoto Prefectural University of Medicine, Kyoto, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    J Mol Cell Cardiol 40:510-9. 2006
    b>Nicorandil has been shown to inhibit myocyte apoptosis by opening of mitochondrial ATP-sensitive potassium (mitoK(ATP)) channels and nitrate-like effect against oxidative stress...
  77. doi Nicorandil-induced ulceration of the penis
    A Birnie
    Department of Dermatology, Nottingham University Hospitals NHS Trust, Nottingham, UK
    Clin Exp Dermatol 33:215-6. 2008
  78. ncbi Nicorandil-induced severe perianal ulceration
    R P Baker
    Department of Coloproctology, Clarendon Wing, Leeds General Infirmary, Great George Street, Leeds, West Yorkshire, UK
    Tech Coloproctol 11:343-5. 2007
    b>Nicorandil is a potassium channel activator used in the prevention and long-term treatment of angina pectoris. It is widely prescribed and its use is supported by data from powerful randomised controlled trials...
  79. ncbi Perianal ulceration and other cutaneous ulcerations complicating nicorandil therapy
    Christina Williams
    J Am Acad Dermatol 56:S116-7. 2007
  80. ncbi Re: King PM, Suttie SA, Jansen JO, Watson AJ. Perforation of the terminal ileum: a possible complication of nicorandil therapy. Surg J R Coll Surg Edinb Irel 2004; 1: 56-57
    C J Cotter
    Surgeon 3:119. 2005
  81. ncbi Assessment of coronary artery disease with nicorandil stress magnetic resonance imaging
    Yoshio Kawase
    Department of Cardiology, Izumi City General Hospital, Osaka, Japan
    Osaka City Med J 50:87-94. 2004
    ..b>Nicorandil, a potassium channel opener, has been reported to increase coronary blood flow and it was associated with fewer ..
  82. ncbi Perianal fistula, colorectal surgery and nicorandil
    S Kamath
    Clin Exp Dermatol 33:192-3. 2008
  83. ncbi Anal ulceration associated with Nicorandil: case series and review of the literature
    L Toquero
    Department of General Surgery, Rotherham Foundation NHS Trust, Rotherham, UK
    Colorectal Dis 8:717-20. 2006
    Use of Nicorandil in the treatment of ischaemic heart disease has been associated with oral, ileal and more recently anal ulceration...
  84. ncbi Comparison of the effects of nicorandil versus verapamil on the incidence of slow flow/no reflow during rotational atherectomy
    Kohichiro Iwasaki
    Department of Cardiology, Okayama Central Hospital, Okayama, Japan
    Am J Cardiol 98:1354-6. 2006
    ..randomized 111 patients with successful rotational atherectomy into a verapamil group (group V, n = 56) and a nicorandil group (group N, n = 55)...
  85. ncbi Influence of nicorandil on the pharmacodynamics and pharmacokinetics of gliclazide in rats and rabbits
    S Satyanarayana
    Pharmacology Division, Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam, 530 003, Andhra Pradesh, India
    Mol Cell Biochem 291:101-5. 2006
    ..b>Nicorandil, a newer antianginal drug widely used now a days acts by opening potassium channels in the cardiac muscle cell ..
  86. ncbi Nicorandil-induced peristomal ulcers: is nicorandil also associated with gastrointestinal fistula formation?
    S Ogden
    Br J Dermatol 156:608-9. 2007
  87. ncbi Nicorandil-induced colonic ulceration: a new cause of colonic ulceration. Report of four cases
    M A Titi
    Department of Surgical Gastroenterology, Gartnavel General Hospital, Glasgow, Scotland, United Kingdom
    Dis Colon Rectum 51:1570-3. 2008
    b>Nicorandil is a widely used third-line treatment for ischemic heart disease. It can be associated with the development of stomatitis and oro-anal ulceration...
  88. ncbi In vivo evaluation of limonene-based transdermal therapeutic system of nicorandil in healthy human volunteers
    Y S R Krishnaiah
    Department of Pharmaceutics, Faculty of Pharmacy, Health Science Center, Kuwait University, Kuwait
    Skin Pharmacol Physiol 18:263-72. 2005
    ..solvent system containing 6% w/w of limonene was effective in promoting the in vitro transdermal delivery of nicorandil. The objective of the present study was to fabricate and evaluate a limonene-based transdermal therapeutic ..
  89. ncbi Comparative effects of nicorandil with isosorbide mononitrate on cardiac sympathetic nerve activity and left ventricular function in patients with ischemic cardiomyopathy
    Shu Kasama
    Department of Cardiovascular Medicine, Gunma University School of Medicine, Maebashi, Japan
    Am Heart J 150:477. 2005
    b>Nicorandil, an adenosine triphosphate-sensitive potassium channel opener, improves left ventricular (LV) remodeling after myocardial infarction in rat models...
  90. ncbi Nicorandil induced oral ulceration
    K Webster
    Department of Maxillofacial Surgery, University Hospital Birmingham Foundation Trust, Edgbaston, Birmingham B15 2TH, UK
    Br Dent J 198:619-21. 2005
    Oral ulceration has many different causes. The association between Nicorandil and oral ulceration is not a new phenomenon...
  91. ncbi Nicorandil reduces the incidence of minor cardiac marker elevation after coronary stenting
    Masaaki Murakami
    Department of Medicine and Medical Science, Okayama University Graduates School of Medicine and Dentistry, Okayama, Japan
    Int J Cardiol 107:48-53. 2006
    ..We examined whether nicorandil, a nicotinamide-nitrate ester, reduces the incidence of minor cardiac marker elevation after coronary stenting.
  92. doi Nicorandil and ulcerations: a NAD/NADP and nicotinic acid-dependent side-effect?
    P Trechot
    Br J Dermatol 158:1150-1. 2008
  93. pmc Nicorandil may be associated with gastrointestinal ulceration
    Mohaned Egred
    Cardiothoracic Centre, Liverpool L14 3PE
    BMJ 332:889. 2006
  94. ncbi Nicorandil and idiopathic anal ulceration
    Mark Katory
    Sheffield Teaching Hospitals NHS Trust, Sheffield, South Yorkshire, United Kingdom
    Dis Colon Rectum 48:1442-6. 2005
    Several reports have implicated nicorandil as a reversible cause of anal ulceration. We have recently commenced a specialist clinic for patients presenting with severe anal ulceration to assess treatment in this difficult group...
  95. pmc Economic evaluation of the impact of nicorandil in angina (IONA) trial
    A Walker
    Robertson Centre for Biostatistics, University of Glasgow, Glasgow, Scotland
    Heart 92:619-24. 2006
    To estimate the net cost of adding nicorandil to usual treatment for patients with angina and to compare this with indicators of health benefit.
  96. pmc Effects of potassium channel openers in the isolated perfused hypokalaemic murine heart
    M J Killeen
    Physiological Laboratory, University of Cambridge, Cambridge, UK
    Acta Physiol (Oxf) 193:25-36. 2008
    We explored the anti-arrhythmic efficacy of K(+) channel activation in the hypokalaemic murine heart using NS1643 and nicorandil, compounds which augment I(Kr) and I(KATP) respectively.
  97. ncbi Use of potassium channel openers for pharmacologic modulation of cardiac excitability
    Kalyanam Shivkumar
    J Cardiovasc Electrophysiol 15:821-3. 2004
  98. ncbi Triggers of ventricular tachyarrhythmias and therapeutic effects of nicorandil in canine models of LQT2 and LQT3 syndromes
    Masaomi Chinushi
    School of Health Science, Niigata University of Medicine, Japan
    J Am Coll Cardiol 40:555-62. 2002
    ..We sought to identify the triggers of ventricular tachyarrhythmia (VTA) in experimental models of long QT type 2 (LQT2) and long QT type 3 (LQT3) syndromes...
  99. ncbi Synergistic effect of nicorandil and amlodipine on mitochondrial function during isoproterenol-induced myocardial infarction in rats
    Venkatachalem Sathish
    Department of Biochemistry and Molecular Biology, University of Madras, Chennai, India
    J Pharm Pharmacol 54:133-7. 2002
    The synergistic effects of nicorandil (KATP-channel opener) and amlodipine (calcium-channel blocker) on heart mitochondrial enzymes and the mitochondrial antioxidant defence system was examined on isoproterenol-induced myocardial ..
  100. ncbi Nicorandil associated anal ulceration
    Angus Watson
    Department of Surgery, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Lancet 360:546-7. 2002
    b>Nicorandil is a vasodilator used to control angina. It has been associated with oral ulceration and stomatitis that resolves upon withdrawal of the drug...
  101. ncbi Oral nicorandil-induced lesions are not aphthous ulcers
    S Boulinguez
    Department of Dermatology, University Hospital Dupuytren, Limoges, France
    J Oral Pathol Med 32:482-5. 2003
    i) To accurately define these lesions determining whether oral nicorandil-induced lesions are aphthous ulcers; (ii) To determine clinical characteristics of oral nicorandil-induced lesions.

Research Grants7

  1. Intraocular pressure regulation via ATP-sensitive potassium channels
    Michael F Romero; Fiscal Year: 2013
    ..We have found that activation of KATP channels by KATP channel openers diazoxide, nicorandil, and P-1075 lower IOP in a human anterior segment perfusion model...
  2. MYOCARDIAL PERFUSION IN THE HYPERTROPHIED HEART
    ROBERT JAMES BACHE; Fiscal Year: 2010
    ..An additional study will determine whether nicorandil, which acts as a preferential mitochondrial KATP channel opener, can protect the heart from the developments of ..
  3. COLLABORATIVE R01-CARDIAC GRAFTS-FUNCTIONAL ANALYSES
    Robert Kloner; Fiscal Year: 2003
    ....
  4. Biologic Ventricular Assist Device
    Robert Kloner; Fiscal Year: 2004
    ..Identification and characterization of transplants will be carried out with PCR analysis of the Y chromosome (male cells into female host), detailed histologic analysis and immunostaining for muscle cell markers. ..
  5. Mesenchymal Stem Cells for Myocardial Infarction
    Robert Kloner; Fiscal Year: 2006
    ..abstract_text> ..
  6. MR Guided Transendocardial Angiogenic Agents
    Maythem Saeed; Fiscal Year: 2007
    ..abstract_text> ..
  7. MECHANISMS OF MYOCARDIAL ISCHEMIC INJURY IN DIABETES
    Judy R Kersten; Fiscal Year: 2010
    ..abstract_text> ..