butanones

Summary

Top Publications

  1. ncbi Evaluation of hydroxyimine as cytochrome P450-selective prodrug structure
    Hanna Kumpulainen
    Department of Pharmaceutical Chemistry, University of Kuopio, PO Box 1627, FI 70211 Kuopio, Finland
    J Med Chem 49:1207-11. 2006
  2. ncbi Performance of a fungal biofilter treating gas-phase solvent mixtures during intermittent loading
    William M Moe
    3418G CEBA Building, Department of Civil and Environmental Engineering, Louisiana State University, Baton Rouge, LA 70803, USA
    Water Res 38:2258-67. 2004
  3. ncbi Neuropathy in an artist exposed to organic solvents in paints: a case study
    Shlomo Moshe
    Hashfela Occupational Medicine Unit, Maccabi Medical Services, Yavne, Israel
    Arch Environ Health 57:127-9. 2002
  4. ncbi [Evaluation of individual exposure to organic solvents using a portable VOC monitor]
    Mitsunori Enomoto
    Department of Hygiene, Dokkyo Medical University School of Medicine, Mibu, Tochigi, Japan
    Sangyo Eiseigaku Zasshi 48:214-20. 2006
  5. ncbi The effect of casting solvent quality on the structure of polymeric Langmuir-Blodgett films
    K Beltsios
    Institute of Physical Chemistry, NCSR Demokritos, Agh. Paraskevi Attikis, 15310, Greece
    J Nanosci Nanotechnol 1:349-56. 2001
  6. ncbi Vibrational assignment, structure and intramolecular hydrogen bond study of 3-amino-1-phenyl-2-buten-1-one
    Haidar Raissi
    Chemistry Department, Birjand University, Birjand 98178, Iran
    Spectrochim Acta A Mol Biomol Spectrosc 63:729-39. 2006
  7. ncbi Comparison of different stationary phases for bioanalytical studies of biologically active compounds
    Anna Zerzanová
    Charles University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry and Drug Control, Hradec Kralove, Czech Republic
    J Sep Sci 29:2126-35. 2006
  8. ncbi Inclusion complexes of nabumetone with beta-cyclodextrins: thermodynamics and molecular modelling studies. Influence of sodium perchlorate
    N Goyenechea
    , , Facultad de Ciencias, Universidad de Navarra, 31080 Pamplona, Spain
    Luminescence 16:117-27. 2001
  9. ncbi Halitosis associated volatiles in breath of healthy subjects
    Sandra Van den Velde
    Department of Periodontology, Catholic University of Leuven, Kapucijnenvoer 33, 3000 Leuven, Belgium
    J Chromatogr B Analyt Technol Biomed Life Sci 853:54-61. 2007
  10. ncbi Prevalence and mechanism of nonsteroidal anti-inflammatory drug-induced clinical relapse in patients with inflammatory bowel disease
    Ken Takeuchi
    Department of Internal Medicine, Guy s, King s, St Thomas Medical School, London, United Kingdom
    Clin Gastroenterol Hepatol 4:196-202. 2006

Detail Information

Publications148 found, 100 shown here

  1. ncbi Evaluation of hydroxyimine as cytochrome P450-selective prodrug structure
    Hanna Kumpulainen
    Department of Pharmaceutical Chemistry, University of Kuopio, PO Box 1627, FI 70211 Kuopio, Finland
    J Med Chem 49:1207-11. 2006
    ..Results indicate that hydroxyimine is a useful intermediate prodrug structure for ketone drugs...
  2. ncbi Performance of a fungal biofilter treating gas-phase solvent mixtures during intermittent loading
    William M Moe
    3418G CEBA Building, Department of Civil and Environmental Engineering, Louisiana State University, Baton Rouge, LA 70803, USA
    Water Res 38:2258-67. 2004
    ..Results indicate that fungal biofilters can be an effective alternative to conventional abatement technologies for treating solvent contaminated off-gases even under discontinuous loading conditions...
  3. ncbi Neuropathy in an artist exposed to organic solvents in paints: a case study
    Shlomo Moshe
    Hashfela Occupational Medicine Unit, Maccabi Medical Services, Yavne, Israel
    Arch Environ Health 57:127-9. 2002
    ..The authors were unable to find any similar case report in the literature...
  4. ncbi [Evaluation of individual exposure to organic solvents using a portable VOC monitor]
    Mitsunori Enomoto
    Department of Hygiene, Dokkyo Medical University School of Medicine, Mibu, Tochigi, Japan
    Sangyo Eiseigaku Zasshi 48:214-20. 2006
    ..The VOC monitor will be useful for reducing occupational exposure. Since the VOC monitor provides detailed data of individuals' exposures to organic solvents...
  5. ncbi The effect of casting solvent quality on the structure of polymeric Langmuir-Blodgett films
    K Beltsios
    Institute of Physical Chemistry, NCSR Demokritos, Agh. Paraskevi Attikis, 15310, Greece
    J Nanosci Nanotechnol 1:349-56. 2001
    ..Experimental observations are supplemented by qualitative polymer physics interpretations regarding the structure of the films upon casting and compression...
  6. ncbi Vibrational assignment, structure and intramolecular hydrogen bond study of 3-amino-1-phenyl-2-buten-1-one
    Haidar Raissi
    Chemistry Department, Birjand University, Birjand 98178, Iran
    Spectrochim Acta A Mol Biomol Spectrosc 63:729-39. 2006
    ..These results also support the stronger hydrogen bond in the title compound with respect to the parent molecule...
  7. ncbi Comparison of different stationary phases for bioanalytical studies of biologically active compounds
    Anna Zerzanová
    Charles University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry and Drug Control, Hradec Kralove, Czech Republic
    J Sep Sci 29:2126-35. 2006
    ..The best conditions for separation of the individual compounds and their metabolites were chosen on the basis of resolution, retention times, and peak symmetry...
  8. ncbi Inclusion complexes of nabumetone with beta-cyclodextrins: thermodynamics and molecular modelling studies. Influence of sodium perchlorate
    N Goyenechea
    , , Facultad de Ciencias, Universidad de Navarra, 31080 Pamplona, Spain
    Luminescence 16:117-27. 2001
    ..It has been found that the stability constants for the complexes decrease with the salt concentration; the causes are discussed...
  9. ncbi Halitosis associated volatiles in breath of healthy subjects
    Sandra Van den Velde
    Department of Periodontology, Catholic University of Leuven, Kapucijnenvoer 33, 3000 Leuven, Belgium
    J Chromatogr B Analyt Technol Biomed Life Sci 853:54-61. 2007
    ..Halitosis can have an intra- or extra-oral origin. In all cases, bad breath is caused by the presence of volatile organic compounds originating from the mouth or the expired air. They can be specific for certain diseases or infections...
  10. ncbi Prevalence and mechanism of nonsteroidal anti-inflammatory drug-induced clinical relapse in patients with inflammatory bowel disease
    Ken Takeuchi
    Department of Internal Medicine, Guy s, King s, St Thomas Medical School, London, United Kingdom
    Clin Gastroenterol Hepatol 4:196-202. 2006
    ..We assessed the effect of these drugs in patients with inflammatory bowel disease (n = 209) and the possible mechanisms...
  11. ncbi Nabumetone: therapeutic use and safety profile in the management of osteoarthritis and rheumatoid arthritis
    Thomas Hedner
    Department of Clinical Pharmacology, Sahlgrenska University Hospital, Goteborg, Sweden
    Drugs 64:2315-43; discussion 2344-5. 2004
    ..Compared with COX-2 selective inhibitors, nabumetone exhibits similar anti-inflammatory and analgesic properties in patients with arthritis and there is no evidence of excess GI or other forms of complications to date...
  12. ncbi Efficacy and safety of rofecoxib 12.5 mg versus nabumetone 1,000 mg in patients with osteoarthritis of the knee: a randomized controlled trial
    Alan J Kivitz
    Altoona Center for Clinical Research, Duncansville, Pennsylvania, USA
    J Am Geriatr Soc 52:666-74. 2004
    ..To evaluate the use of starting doses of rofecoxib and nabumetone in patients with osteoarthritis (OA) of the knee...
  13. ncbi Effects of NSAIDs on cryoprobe-induced gastric ulcer healing in rats
    J Tibble
    Department of Medicine, Guy's, King's and St Thomas' Medical School, London, UK
    Aliment Pharmacol Ther 15:2001-8. 2001
    ..CONCLUSIONS: Celecoxib and indometacin both decreased the epithelial proliferative response and delayed healing of cryoprobe-induced gastric ulcers. In contrast, nabumetone impaired ulcer healing only at very high doses...
  14. ncbi Patient characteristics associated with outpatient prescriptions for nabumetone and oxaprozin versus celecoxib and rofecoxib
    Allen Brinker
    Division of Drug Risk Evaluation, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD 20857, USA
    Am J Health Syst Pharm 62:739-43. 2005
  15. ncbi Tolerability to nabumetone and meloxicam in patients with nonsteroidal anti-inflammatory drug intolerance
    Alicia Prieto
    Allergy Service, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    J Allergy Clin Immunol 119:960-4. 2007
    ..Because nonsteroidal anti-inflammatory drug (NSAID) intolerance depends on COX-1 inhibition, preferential or selective COX-2 inhibitors have been thought to be well tolerated by these patients...
  16. pmc A comparison of the effects of nabumetone vs meloxicam on serum thromboxane B2 and platelet function in healthy volunteers
    D J W van Kraaij
    Department of Cardiology, Academic Hospital Maastricht, Maastricht, The Netherlands
    Br J Clin Pharmacol 53:644-7. 2002
    ..To compare the effects of nabumetone and meloxicam, two cyclo-oxygenase-2 (COX-2) preferential nonsteroidal anti-inflammatory drugs (NSAIDs), on platelet COX-1 activity and platelet function...
  17. ncbi Treatment of patients with osteoarthritis with rofecoxib compared with nabumetone
    Arthur L Weaver
    University of Nebraska Medical Center, Omaha, Nebraska, USA
    J Clin Rheumatol 12:17-25. 2006
    ..Rofecoxib and nabumetone were developed to provide gastrointestinal benefits over traditional nonsteroidal antiinflammatory drugs (NSAIDs). However, there is limited comparative information relating to these 2 drugs...
  18. ncbi In vitro investigation of the effects of cyclooxygenase-2 inhibitors on contractile activity of the equine dorsal and ventral colon
    Linda M Van Hoogmoed
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis 95616, USA
    Am J Vet Res 63:1496-500. 2002
    ..To evaluate the effect of 2 cyclooxygenase (COX)-2 inhibitors on contractile activity of the circular smooth muscle layer of the equine dorsal and ventral colon...
  19. ncbi Novel determination of nabumetone, a cox-2 inhibitor precursor via its 4-carboxyl-2,6-dinitrobenzene diazonium (CDNBD) derived AZO dye
    A O Adegoke
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria
    Afr J Med Med Sci 36:249-57. 2007
    ..05) with the official (B.P) HPLC method. The new method is simple, has the main advantage of employing a more affordable instrumentation and could find application in routine in-process quality control of nabumetone tablets...
  20. ncbi Storage stability of ketones on carbon adsorbents
    C Prado
    Instituto de Seguridad y Salud Laboral, Apartado 35, E 30120 El Palmar, Región de Murcia, Murcia, Spain
    J Chromatogr A 1129:82-7. 2006
    ..After 30-days storage, the stability of the studied ketones was excellent on Carboxen 564. This sorbent had a nearly negligible ash content and the adsorbed water was much lower than for the other sorbents tested...
  21. ncbi Sub-chronic toxicity of low concentrations of industrial volatile organic pollutants in vitro
    Catherine McDermott
    Environmental Research Institute, University College Cork, Cork, Ireland
    Toxicol Appl Pharmacol 219:85-94. 2007
    ..The lowest-observed-adverse-effect-levels (LOAELs) measured in vitro were close to blood solvent concentrations reported for individuals exposed to the agents at levels at or below their individual threshold limit values (TLVs)...
  22. ncbi Increase in exhaled nitric oxide in shoe and leather workers at the end of the work-shift
    Mauro Maniscalco
    Department of Pharmacology and Physiology, Karolinska Institute Stockholm, Stockholm, Sweden
    Occup Med (Lond) 54:404-7. 2004
    ..The objective of this study was to evaluate exhaled NO levels in synthetic leather workers exposed to organic solvents toluene, xylene and methylethyl ketone...
  23. ncbi New approach to generalized two-dimensional correlation spectroscopy. II: Eigenvalue manipulation transformation (EMT) for noise suppression
    Young Mee Jung
    Department of Chemistry, Pohang University of Science and Technology, San 31, Hyojadong, Pohang 790 784, Korea
    Appl Spectrosc 57:557-63. 2003
    ..The effect of this new EMT scheme is more gradual, with attractive flexibility to continuously fine-tune the balance between the desired noise reduction effect and the retention of pertinent spectral information...
  24. ncbi In vitro exposure of jurkat T-cells to industrially important organic solvents in binary combination: interaction analysis
    Catherine McDermott
    Environmental Research Institute, University College Cork, Lee Maltings, Ireland
    Toxicol Sci 101:263-74. 2008
    ..It is concluded that toxicity in immune-derived T cells may exhibit greater than additive effects when there is coexposure to organic solvents. This may have implications for risk assessment of environmental exposure to these agents...
  25. ncbi Evaluation of current biological exposure index for occupational N, N-dimethylformamide exposure from synthetic leather workers
    Ven Shing Wang
    Department of Occupational Safety and Health, China Medical University, No 91 Hsueh Shih Road, Taichung, Taiwan, Republic of China
    J Occup Environ Med 46:729-36. 2004
    ..Urinary concentration of NMF and DMF, corresponding to the 8-hour exposure to airborne DMF at 30 mg/m, was estimated to 38.4 mg/L or 39.4 mg/g creatinine for NMF and to 0.92 mg/L or 0.96 mg/g creatinine for DMF...
  26. ncbi A sensitive method for the quantification of acrolein and other volatile carbonyls in ambient air
    Vincent Y Seaman
    Department of Environmental Toxicology, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
    Anal Chem 78:2405-12. 2006
    ..02 microg/m3. The minimum detection limit of 0.012 microg/m3 is below that of other published methods. Methacrolein, methyl vinyl ketone, crotonaldehyde, glyoxal, methyl glyoxal, and benzaldehyde were also quantified...
  27. ncbi Asymmetric organocatalytic direct aldol reactions of ketones with alpha-keto acids and their application to the synthesis of 2-hydroxy-gamma-butyrolactones
    Xiao Ying Xu
    Hefei National Laboratory for Physical Sciences at Microscale and Department of Chemistry, University of Science and Technology of China, Hefei 230026, China
    J Org Chem 72:9905-13. 2007
    ..These two hydrogen-bonding interactions are important for the reactivity and enantioselectivity of the direct asymmetric aldol condensation...
  28. ncbi Highly asymmetric Michael addition to alpha,beta-unsaturated ketones catalyzed by 9-amino-9-deoxyepiquinine
    Jian Wu Xie
    Graduate School of the Chinese Academy of Sciences, Beijing, P R China
    Angew Chem Int Ed Engl 46:389-92. 2007
  29. ncbi General principles of pharmaceutical solid polymorphism: a supramolecular perspective
    Barbara Rodríguez-Spong
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, MI 48109 1065, USA
    Adv Drug Deliv Rev 56:241-74. 2004
    ..This review describes pharmaceutical solids in terms of supramolecular chemistry and crystal engineering concepts, and discusses the events that control crystallization and solid phase transformations...
  30. pmc Calculation of absolute protein-ligand binding affinity using path and endpoint approaches
    Michael S Lee
    Department of Cell Biology and Biochemistry, U S Army Medical Research Institute of Infectious Diseases, Frederick, Maryland 21702, USA
    Biophys J 90:864-77. 2006
    ..For example, conventional harmonic and quasiharmonic entropy estimation procedures produce disparate results for the relatively simple protein-ligand systems studied in this work...
  31. ncbi Hydration of aprotic donor solvents studied by means of FTIR spectroscopy
    Emilia Gojło
    Department of Physical Chemistry, Chemical Faculty, Gdansk University of Technology, Narutowicza 11 12, 80 952 Gdansk, Poland
    J Phys Chem A 111:1827-34. 2007
    ..The simple model of hydration, proposed to better justify the results, connects the values obtained from the methods providing microscopic and macroscopic characteristics of the system studied...
  32. ncbi Effects of acetone on methyl ethyl ketone peroxide runaway reaction
    Yan Fu Lin
    Department of Chemistry, National Chung Hsing University, 250 Kuo Kwang Road, Taichung 40227, Taiwan, ROC
    J Hazard Mater 153:1071-7. 2008
    ....
  33. ncbi Measurement and modeling of single- and multi-component adsorption equilibria of VOC on high-silica zeolites
    Pierre Monneyron
    LIPE, Département de Génie des Procédés Industriels, Institut National des Sciences Appliquees, 135 Avenue de Rangueil, 31077 Toulouse 4, France
    Environ Sci Technol 37:2410-4. 2003
    ....
  34. ncbi Antihypertensive effect of the combination of fosinopril and HCTZ is resistant to interference by nonsteroidal antiinflammatory drugs
    V Thakur
    Department of Medicine, Louisiana State University Medical Center, New Orleans 70112, USA
    Am J Hypertens 12:925-8. 1999
    ..We conclude that the three NSAID did not neutralize the antihypertensive effect of the combination of fosinopril and HCTZ, and hence the blood pressure lowering action of the combination may not be prostaglandin dependent...
  35. ncbi Association of immunological disorders in lethal side effect of NSAIDs on beta-glucan-administered mice
    H Takahashi
    Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, 192-0392, Tokyo, Japan
    FEMS Immunol Med Microbiol 31:1-14. 2001
    ..These facts strongly suggested that gastrointestinal damage by NSAIDs was more severe in beta-glucan-administered mice, resulting in peritonitis by enteric bacteria and leading to death...
  36. ncbi Comparison of cardiovascular thrombotic events in patients with osteoarthritis treated with rofecoxib versus nonselective nonsteroidal anti-inflammatory drugs (ibuprofen, diclofenac, and nabumetone)
    Alise S Reicin
    Merck Research Laboratories Merck and Co, Inc, Rahway, New Jersey 07065, USA
    Am J Cardiol 89:204-9. 2002
    ..Thus, in the rofecoxib osteoarthritis development program, there was no difference between rofecoxib, comparator nonselective NSAIDs, and placebo in the risks of cardiovascular thrombotic events...
  37. ncbi Distal bowel selectivity in the chemoprevention of experimental colon carcinogenesis by the non-steroidal anti-inflammatory drug nabumetone
    H K Roy
    Department of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-2000, USA
    Int J Cancer 92:609-15. 2001
    ..The striking distal predilection of nabumetone may be, at least partially, explained by distal bowel over-expression of COX-2 and PPAR-delta...
  38. ncbi Photosensitizing properties of 6-methoxy-2-naphthylacetic acid, the major metabolite of the phototoxic non-steroidal anti-inflammatory and analgesic drug nabumetone
    N Canudas
    Laboratorio de Fotoquímica y Fotobiología, Departamento de Quimica, Universidad Simon Bolivar, Venezuela
    Pharmazie 60:604-8. 2005
    ..6-MNAA was phototoxic to C. albicans, C. lipolytica and C. tropicalis. A mechanism involving singlet oxygen, radicals, and electron transfer reactions is suggested for the observed phototoxicity...
  39. ncbi Spontaneous reports of hypertension leading to hospitalisation in association with rofecoxib, celecoxib, nabumetone and oxaprozin
    Allen Brinker
    Division of Drug Risk Evaluation, Office of Drug Safety, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20875, USA
    Drugs Aging 21:479-84. 2004
    ..We also collapse cases into series for the identification of possible risk factors for clinically severe, NSAID-associated hypertension...
  40. ncbi A population based historical cohort study of the mortality associated with nabumetone, Arthrotec, diclofenac, and naproxen
    Nigel L Ashworth
    Division of Physical Medicine and Rehabilitation, University of Alberta, Edmonton, Alberta, Canada
    J Rheumatol 31:951-6. 2004
    ....
  41. pmc Calculation of cyclodextrin binding affinities: energy, entropy, and implications for drug design
    Wei Chen
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, Maryland 20850, USA
    Biophys J 87:3035-49. 2004
    ..In close analogy with the common experimental observation of entropy-enthalpy compensation, the computed entropy changes show a near-linear relationship with the changes in mean potential plus solvation energy...
  42. ncbi The nonsteroidal anti-inflammatory drug, nabumetone, differentially inhibits beta-catenin signaling in the MIN mouse and azoxymethane-treated rat models of colon carcinogenesis
    Hemant K Roy
    Department of Internal Medicine, Evanston Northwestern Healthcare Research Institute, 1001 University Place, Evanston, IL 60201, USA
    Cancer Lett 217:161-9. 2005
    ..In conclusion, we demonstrate that the differential mechanisms for beta-catenin suppression may be determined, at least partly, by GSK-3beta...
  43. pmc Chemoprevention of intestinal tumorigenesis by nabumetone: induction of apoptosis and Bcl-2 downregulation
    H K Roy
    Department of Internal Medicine, University of Nebraska Medical Center Eppley Cancer Institute, 982000 Nebraska Medical Center, Omaha, NE 68198 2000, USA
    Br J Cancer 84:1412-6. 2001
    ....
  44. ncbi Comparison of the efficacy and safety of naproxen CR and nabumetone in the treatment of patients with osteoarthritis of the knee
    H S Cha
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Int J Clin Pharmacol Ther 39:539-45. 2001
    ..CONCLUSIONS: Naproxen CR is an effective and tolerable drug in the treatment of knee OA. Efficacy and safety profiles are comparable to those of nabumetone...
  45. ncbi Treatment of elderly patients with nabumetone or diclofenac: gastrointestinal safety profile
    G J Morgan
    Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    J Clin Gastroenterol 32:310-4. 2001
    ..However, the gastrointestinal safety profile of nabumetone was superior to that of diclofenac with respect to elevation of liver enzymes...
  46. ncbi Pulp-dentine complex changes and root resorption during intrusive orthodontic tooth movement in patients prescribed nabumetone
    Paula A Villa
    Instituto de Ciencias de la Salud CES, Medellin, Colombia
    J Endod 31:61-6. 2005
    ..Nabumetone was found to be useful in reducing pulpitis, external root resorption, and pain caused by intrusive orthodontic movement, without altering tooth movement in response to the application of orthodontic force...
  47. pmc 2, 4-diamino-6- hydroxy pyrimidine inhibits NSAIDs induced nitrosyl-complex EPR signals and ulcer in rat jejunum
    S Somasundaram
    Lineberger Comprehensive Cancer Center, CB 7295, University of North Carolina, Chapel Hill, NC 27599, USA
    BMC Gastroenterol 2:8. 2002
    ..We investigated the latter possibility using electron paramagnetic resonance spectroscopy...
  48. ncbi Pain management in osteoarthritis: a focus on onset of efficacy--a comparison of rofecoxib, celecoxib, acetaminophen, and nabumetone across four clinical trials
    Wendy P Battisti
    Merck and Co, Inc, West Point, Pennsylvania 19486, USA
    J Pain 5:511-20. 2004
    ..5 mg (P = .01) compared with nabumetone. Rofecoxib treatment, with its faster onset of OA efficacy and lower rates of related discontinuations, might provide efficacy advantages in the treatment of OA pain...
  49. pmc A novel and efficient method to prepare 2-aryltetrahydrofuran-2-ylphosphonic acids
    Vsevolod V Komissarov
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov St, 32, Moscow 119991, Russia
    Beilstein J Org Chem 6:63. 2010
    A novel one-pot method was developed for the synthesis of the title compounds starting from 4-chloro-1-aryl-1-butanones 1, phosphorus trichloride and acetic acid. The end products 2 were obtained in 20-94% yield...
  50. ncbi Ocular hypotensive and vasodilative effects of two beta-adrenergic blockers with intrinsic sympathomimetic activity
    S J Hong
    Department of Pharmacology, Kaohsiung Medical College, Taiwan, ROC
    Curr Eye Res 17:700-7. 1998
    ..The ocular hypotensive and vasodilative effects of vaninolol and eugenolol, two beta-adrenergic blockers with intrinsic sympathomimetic activity, were tested in rabbits and their pharmacologic mechanisms were also studied in vitro...
  51. ncbi The use of particle beam mass spectrometry for the measurement of impurities in a nabumetone drug substance, not easily amenable to atmospheric pressure ionisation techniques
    J C Wolff
    Analytical Sciences, SmithKline Beecham Pharmaceuticals, Harlow CM19 5AW, UK
    Rapid Commun Mass Spectrom 15:265-72. 2001
    ..By using 20 mg/mL solutions of nabumetone, impurities at levels of about 250 ppm mass fraction relative to nabumetone could be detected. Results were compared with LC/API-MS and previous GC/MS...
  52. pmc Tolerance of diclofenac after hypersensitivity to celecoxib and to nabumetone
    Benjamin Wyplosz
    Br J Clin Pharmacol 61:474. 2006
  53. ncbi Atmospheric chlorine chemistry in southeast Texas: impacts on ozone formation and control
    Sunghye Chang
    Center for Energy and Environmental Resources, The University of Texas at Austin, Austin, TX 78758, USA
    Environ Sci Technol 40:251-62. 2006
    ..Chlorine emissions also influenced changes in ozone concentrations due to hydrocarbon and NOx emission controls...
  54. ncbi The loss of the chemical tanker Ievoli Sun in the English Channel, October 2000
    Robin J Law
    Centre for Environment, Fisheries and Aquaculture Science, CEFAS Burnham Laboratory, Remembrance Avenue, Burnham on Crouch, Essex CM0 8HA, UK
    Mar Pollut Bull 46:254-7. 2003
    ..The remainder of the styrene and the ship's main bunker fuel were recovered from the wreck on the seabed, whilst the two chemical solvents were released to the water column in a slow, controlled manner...
  55. ncbi Pharmacological and metabolic interactions between ethanol and methyl n-butyl ketone, methyl isobutyl ketone, methyl ethyl ketone, or acetone in mice
    J Cunningham
    , , , , Canada
    Fundam Appl Toxicol 13:102-9. 1989
    ..It is concluded that enhancement of the ethanol-induced loss of righting reflex by these solvents in mice is well correlated to reduced elimination rate of ethanol...
  56. ncbi Protection of hexaprenyl-diphosphate synthase of Micrococcus luteus B-P 26 against inactivation by sulphydryl reagents and arginine-specific reagents
    I Yoshida
    Chemical Research Institute of Non Aqueous Solutions, Tohoku University, Sendai, Japan
    Biochim Biophys Acta 995:138-43. 1989
    ..These results suggest that the catalytic site of the synthase is formed by cooperative interaction between components A and B, and that cysteine and arginine residues on component B play important roles in the synthase activity...
  57. pmc Acetohydroxy acid synthetase with a pH optimum of 7.5 from Neurospora crassa mitochondria: characterization and partial purification
    L Glatzer
    J Bacteriol 112:453-64. 1972
    ..Both forms are electrophoretically and antigenically similar but one form has an estimated molecular weight of 110,000 to 120,000 whereas the predominant form is a much larger and more buoyant molecule...
  58. ncbi Antimutagenic effects of dehydrozingerone and its analogs on UV-induced mutagenesis in Escherichia coli
    N Motohashi
    Department of Radiopharmacy, Kobe Pharmaceutical University, Japan
    Mutat Res 377:17-25. 1997
    ..Benzalacetone, 2-hydroxybenzalacetone and 4-phenyl-3-butyn-2-one that were effective on the UV-induced mutagenesis also decreased the gamma-induced mutagenesis in Salmonella typhimurium TA2638...
  59. ncbi Comparative effects of indomethacin and nabumetone on urine and electrolyte output in conscious rats
    Idris bin Long
    Department of Physiology, School Medical Sciences, University Sains Malaysia, Kelantan, Malaysia
    J Pharmacol Sci 99:272-6. 2005
    ..01). It appears that indomethacin and nabumetone when given at maximum human therapeutic doses may affect urine and electrolyte output in conscious rats...
  60. ncbi Enhancing the synthetic utility of aldolase antibody 38C2
    Kalyani Mondal
    Chemistry Department, Indian Institute of Technology, Delhi, Hauz Khas, New Delhi 110016, India
    Bioorg Med Chem Lett 16:807-10. 2006
    ..Crosslinked aggregate of 38C2, however, gave the biocatalyst which gave a single product and could be reused at 40 degrees C five times without loss of activity...
  61. pmc Non-steroidol anti-inflammatory drug effect on crypt cell proliferation and apoptosis during initiation of rat colon carcinogenesis
    C J Barnes
    Department of Medicine, University of Texas Health Science Center, San Antonio 78284 7878, USA
    Br J Cancer 77:573-80. 1998
    ..Aspirin may suppress tumour incidence via salicylate by enhancing apoptosis in carcinogen-initiated cells...
  62. doi Synthesis and antifungal activity of beta-trifluoroalkyl aminovinyl ketone derivatives
    Gary Gellerman
    Department of Biological Chemistry, Ariel University Center of Samaria, Ariel 40700, Israel
    J Agric Food Chem 57:8303-7. 2009
    ..We propose that (Z)-3-amino-4,4,4-trifluoro-1-phenylbut-2-en-1-one is the minimal structural requirement for a beta-trifluoroalkyl aminovinyl ketone fungitoxic derivative...
  63. doi Synthesis and anti-inflammatory activity of novel (substituted)benzylidene acetone oxime ether derivatives: molecular modeling study
    Mohammed I El-Gamal
    Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura 35516, Egypt
    Eur J Med Chem 45:1403-14. 2010
    ..Docking study of the synthesized compound 7a into the active site of COX-1 and COX-2 revealed a similar binding mode to SC-558, a selective COX-2 inhibitor...
  64. ncbi Non-steroidal anti-inflammatory drug, nabumetone, prevents indometacin-induced gastric damage via inhibition of neutrophil functions
    Yoshiro Ishiwata
    Central Research Laboratory, Sanwa Kagaku Kenkyusho Co Ltd, Mie, Japan
    J Pharm Pharmacol 55:229-37. 2003
    ..These results suggest that nabumetone prevents gastric damage induced by the active metabolite, 6MNA, via the suppression of neutrophil activation in gastric mucosa...
  65. ncbi [Ozonolysis of methacrolein and methyl vinyl ketone in aqueous solutions]
    Li Hua Zhu
    The State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Science, Peking University, Beijing 100871, China
    Huan Jing Ke Xue 26:83-6. 2005
    ..9, 26.6 +/- 3.9, 4.6 +/- 0.4 and 10.0 +/- 0.8 respectively for MAC; 40.8+/- 2.2, 40.7 +/- 3.5, 6.8 +/- 0.5 and 10.4 +/- 0.8 respectively for MVK. Finally, the reaction mechanisms are deduced to explain the formation of products observed...
  66. ncbi Cyclooxygenase selectivity of non-steroid anti-inflammatory drugs in humans: ex vivo evaluation
    F Giuliano
    Department of Cardiac, Vascular and Inflammation Research, The William Harvey Research Institute, St. Bartholomew's and the Royal London School of Medicine and Dentistry, Charterhouse Square, EC1M 6BQ, London, UK
    Eur J Pharmacol 426:95-103. 2001
    ....
  67. ncbi Assessment of microbial populations in methyl ethyl ketone degrading biofilters by denaturing gradient gel electrophoresis
    C Li
    Department of Civil and Environmental Engineering, Louisiana State University, Baton Rouge, LA 70803, USA
    Appl Microbiol Biotechnol 64:568-75. 2004
    ....
  68. pmc Cyclobutenone as a highly reactive dienophile: expanding upon Diels-Alder paradigms
    Xiaohua Li
    Department of Chemistry, Columbia University, Havemeyer Hall, 3000 Broadway, New York, New York 10027, USA
    J Am Chem Soc 132:11004-5. 2010
    ....
  69. doi Removal of benzene and methyl ethyl ketone vapor: comparison of hypercrosslinked polymeric adsorbent with activated carbon
    Chao Long
    State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, 163 Xianlin Road, Nanjing 210046, China
    J Hazard Mater 203:251-6. 2012
    ..Therefore, HY-1 will be a particularly efficient and competitive adsorbent for VOCs recovery, especially at medium-high concentrations...
  70. ncbi Qualitative analysis and HPLC isolation and identification of procyanidins from Vicia faba
    Rachid Merghem
    UFR de Biologie, Laboratoire de Phytochimie, Båt F A Forel, Universite Claude Bernard Lyon 1, F 69622 Villeurbanne Cedex, France
    Phytochem Anal 15:95-9. 2004
    ..The major condensed tannins of Vicia faba comprise six compounds identified as two A-type procyanidin dimers, the procyanidin dimers B1, B2 and B3, and a procyanidin trimer...
  71. doi Generation of arynes via ate complexes of arylboronic esters with an ortho-leaving group
    Yuto Sumida
    Laboratory of Chemical Bioscience, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2 3 10 Kanda surugadai, Tokyo 101 0062, Japan
    Org Lett 15:2806-9. 2013
    ..The ready availability of the aryne precursors and mutual orthogonality in aryne generation with widely used ortho-silylaryl triflate have enhanced the utility of the method...
  72. doi Nano-micrometer-architectural acidic silica prepared from iron oxide of Leptothrix ochracea origin
    Hideki Hashimoto
    Graduate School of Natural Science and Technology, Okayama University, Okayama 700 8530, Japan
    ACS Appl Mater Interfaces 5:5194-200. 2013
    ..The acidity of this new silica material was confirmed through representative two catalytic reactions: ring-opening reaction and Friedel-Crafts-type reaction, both of which are known to require acid catalysts...
  73. ncbi In plants the alc gene expression system responds more rapidly following induction with acetaldehyde than with ethanol
    Björn H Junker
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Golm, Germany
    FEBS Lett 535:136-40. 2003
    ..We propose that this system is therefore ideal for the temporal regulation of important metabolic enzyme activities...
  74. pmc Alcohol dehydrogenase- and rat liver cytosol-dependent bioactivation of 1-chloro-2-hydroxy-3-butene to 1-chloro-3-buten-2-one, a bifunctional alkylating agent
    Adnan A Elfarra
    Department of Comparative Biosciences and the Molecular and Environmental Toxicology Center, University of Wisconsin Madison, Madison, WI 53706, USA
    Chem Res Toxicol 25:2600-7. 2012
    ..Collectively, the results provide clear evidence for CHB bioactivation by ADH and rat liver cytosol to yield CBO. The bifunctional alkylating ability of CBO suggests that it may play a role in BD toxicity and/or carcinogenicity...
  75. doi Asymmetric synthesis of (R)-1,3-butanediol from 4-hydroxy-2-butanone by a newly isolated strain Candida krusei ZJB-09162
    Ren Chao Zheng
    Institute of Bioengineering, Zhejiang University of Technology, Hangzhou, People s Republic of China
    Appl Microbiol Biotechnol 94:969-76. 2012
    ..0 g/L gave (R)-1,3-butanediol in 38.7 g/L and 83.9% conversion. Therefore, C. krusei ZJB-09162 was, for the first time, proven to be a promising biocatalyst for enzymatic preparation of (R)-1,3-butanediol...
  76. ncbi Rational design, synthesis and evaluation of (6aR( *),11bS( *))-1-(4-fluorophenyl)-4-{7-[4-(4-fluorophenyl)-4-oxobutyl]1,2,3,4,6,6a,7,11b,12,12a(RS)-decahydropyrazino[2',1':6,1]pyrido[3,4-b]indol-2-yl}-butan-1-one as a potential neuroleptic agent
    Ruchika Chakrabarty
    Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, India
    Bioorg Med Chem 15:7361-7. 2007
    ..15). It blocks amphetamine induced hyperactivity/stereotypy and secondary conditioned avoidance responses in rodents at lower doses than those required for the neuroleptic drugs haloperidol and centbutindole (biriperone)...
  77. ncbi Trends in medication use for osteoarthritis treatment
    John C Ausiello
    Institute for Health Policy, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    J Rheumatol 29:999-1005. 2002
    ..To investigate recent national trends in nonsteroidal antiinflammatory drug (NSAID) and acetaminophen use for osteoarthritis (OA)...
  78. pmc Noncovalent cell surface engineering: incorporation of bioactive synthetic glycopolymers into cellular membranes
    David Rabuka
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    J Am Chem Soc 130:5947-53. 2008
    ..This system provides a platform to study cell-surface phenomena with a degree of chemical control that cannot be achieved using conventional biological tools...
  79. doi Solubilisation of drugs in micellar solutions of diblock copolymers of ethylene oxide and styrene oxide
    Michael Crothers
    School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, UK
    Int J Pharm 358:303-6. 2008
    ..The highest solubilisation capacities were found for a copolymer with worm-like micelles...
  80. doi Characteristic hydrocarbons and 2-alkylcyclobutanones for detecting gamma-irradiated sesame seeds after steaming, roasting, and oil extraction
    Jeongeun Lee
    Department of Food Science and Technology, Kyungpook National University, Daegu 702 701, Korea
    J Agric Food Chem 56:10391-5. 2008
    ..These compounds could be detected at doses > or =0.5 kGy but not in non-irradiated samples. The three types of treatments had no significant effect on the levels of 2-alkylcyclobutanones...
  81. doi Effect of a nonprotein bioactive agent on the reduction of cyclooxygenase-2 and tumor necrosis factor-alpha in human intervertebral disc cells in vitro
    Tatsuhiro Yoshida
    Department of Orthopaedic Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    J Neurosurg Spine 9:411-8. 2008
    ....
  82. doi A review of analytical techniques for determination of oxicams, nimesulide and nabumetone
    Małgorzata Starek
    Department of Inorganic and Analytical Chemistry, Jagiellonian University, Collegium Medicum, Cracow, Poland
    Talanta 77:925-42. 2009
    ..Presented application concerns analysis of chosen NSAIDs from pharmaceutical formulations and biological samples...
  83. doi Evaluation of the in-vitro cidal activity and toxicity of a novel peroxygen biocide: 2-butanone peroxide
    J Garcia-de-Lomas
    Microbiology Department, School of Medicine, University of Valencia, Valencia, Spain
    J Hosp Infect 68:248-54. 2008
    ..The skin sensitisation test was negative. The safety profile in the toxicity tests and the basic cidal activity against the strains tested suggest that 2-butanone peroxide in the control of hospital infections...
  84. doi N-acetylcysteine and hemodialysis treatment of a severe case of methyl ethyl ketone peroxide intoxication
    C C G van Enckevort
    Department of Internal Medicine, Haga Hospital, The Hague, The Netherlands
    Clin Toxicol (Phila) 46:74-8. 2008
    ..Treatment with a combination of N-acetylcysteine and haemodialysis may be a promising therapy for this severe and potentially life-threatening intoxication...
  85. ncbi Accurate measurements of small J coupling constants under inhomogeneous fields via intermolecular multiple-quantum coherences
    Yanqin Lin
    Department of Physics, State Key Laboratory for Physical Chemistry of Solid Surface, Xiamen University, Xiamen, Fujian, PR China
    J Magn Reson 190:298-306. 2008
    ..For spin systems with small scalar coupling constants, well-resolved J-spectra can be achieved by selecting a proper scaling factor. Theoretical predictions are in good agreement with simulation results and experimental observations...
  86. ncbi The different patterns of blood pressure elevation by rofecoxib and nabumetone
    T Reitblat
    Rheumatology Outpatient Clinics, Barzilai Medical Centre, affiliated with the Faculty of Health Science, Ben Gurion University of the Negev, Ashkelon, Israel
    J Hum Hypertens 16:431-4. 2002
    ..Nabumetone caused a moderate increase of day and night BP, without changes in biological diurnal variation...
  87. ncbi Changes in n-hexane toxicokinetics in short-term single exposure due to co-exposure to methyl ethyl ketone in volunteers
    Eiji Shibata
    Department of Medical Technology, Nagoya University School of Health Sciences, 1 1 20 Daiko Minami, Higashi ku, Nagoya, 461 8673 Japan
    Int Arch Occup Environ Health 75:399-405. 2002
    ..The aim of the present study was to describe the influence of co-exposure to MEK on n-hexane toxicokinetics in humans...
  88. ncbi The effects of nabumetone, a cyclooxygenase-2 inhibitor, on cisplatin-induced 5-hydroxytryptamine release from the isolated rat ileum
    C Kudo
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan
    Res Commun Mol Pathol Pharmacol 110:117-32. 2001
    ..On the other hand, there is a possibility that dexamethasone works through a mechanism other than 5-HT release in delayed emesis...
  89. ncbi Baylis-Hillman reaction: convenient ascending syntheses and biological evaluation of acyclic deoxy monosaccharides as potential antimycobacterial agents
    Rashmi Pathak
    Medicinal Chemistry Division, Central Drug Research Institute, Lucknow, India
    Bioorg Med Chem 10:3187-96. 2002
    ..Among the compounds evaluated for their antimycobacterial activity, compound (10) showed the desired activity in the range of 3.125 microg/mL...
  90. ncbi Effect of polymer molecular weight on the production of drug nanoparticles
    S Sepassi
    Department of Pharmacy, King s College London, 150 Stamford Street, London SE1 9NH, United Kingdom
    J Pharm Sci 96:2655-66. 2007
    ..The slightly lower concentration of HMPC found to be present on the surface of the halofantrine nanoparticles compared with the nabumetone nanoparticles suggested a differing affinity of the polymer for the surface of the two drugs...
  91. doi Thermal explosion analysis of methyl ethyl ketone peroxide by non-isothermal and isothermal calorimetric applications
    Jen Hao Chi
    Department of Fire Science, WuFeng Institute of Technology, Ming Hsiung, Chiayi 62153, Taiwan, ROC
    J Hazard Mater 171:1145-9. 2009
    ....
  92. doi Heme oxygenase inhibition by 2-oxy-substituted 1-azolyl-4-phenylbutanes: effect of variation of the azole moiety. X-ray crystal structure of human heme oxygenase-1 in complex with 4-phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone
    Gheorghe Roman
    Department of Chemistry, Queen s University, Kingston, ON K7L 3N6, Canada
    Chem Biol Drug Des 75:68-90. 2010
    A series of 1-azolyl-4-phenyl-2-butanones was designed and synthesized for the inhibition of heme oxygenases (heme oxygenase-1 and heme oxygenase-2)...
  93. ncbi Effects of an external exposure to 200 ppm methyl ethyl ketone on nasal mucosa in healthy volunteers
    A Muttray
    Institut für Arbeits, Sozial und Umweltmedizin der Johannes Gutenberg Universität Mainz, Germany
    Int Arch Occup Environ Health 75:197-200. 2002
    ..To investigate the effects of an acute exposure to 200 ppm methyl ethyl ketone on the nasal mucosa of healthy volunteers...
  94. ncbi Kinetics of the diacetyl and 2,3-pentanedione reduction by diacetyl reductase (alpha-diketone reductase (NAD)) from Staphylococcus aureus
    J Gonzalez
    Facultad de Veterinaria, Universidad de Leon, Spain
    Biochimie 70:1791-7. 1988
    ..This condition is not adequate to play the role, formerly proposed for diacetyl reductases, of regulating the equilibrium between oxidized and reduced forms of pyridine-nucleotides...
  95. ncbi Reductive metabolism In vivo of trans-4-phenyl-3-buten-2-one in rats and dogs
    S Kitamura
    Institute of Pharmaceutical Science, Hiroshima University, School of Medicine, Hiroshima, Japan
    Drug Metab Dispos 27:767-9. 1999
    ..PBO was mutagenic in the Ames test using Salmonella typhimurium TA 100 when S-9 mix was added, but PBA and PBOL were not. It appears that PBO is mainly metabolized to PBA in vivo in rats and dogs as a detoxification pathway...
  96. doi Portable formaldehyde monitoring device using porous glass sensor and its applications in indoor air quality studies
    Yasuko Yamada Maruo
    NTT Energy and Environment Systems Laboratories, 3 1 Morinosato Wakamiya, Atsugi shi, Kanagawa 243 0198, Japan
    Anal Chim Acta 702:247-53. 2011
    ....
  97. doi Complex suicide by ethanol intoxication and inhalation of fire fumes in an old lady: interdisciplinary elucidation including post-mortem analysis of congener alcohols
    L Jungmann
    Institute of Legal Medicine, Freiburg University Medical Centre, Freiburg, Germany
    Forensic Sci Int 209:e11-5. 2011
    ..Congener analysis of the gastric contents and the femoral blood indicated the uptake of a fruit distillate or its foreshot...
  98. ncbi Bacterial metabolites of an entomopathogenic bacterium, Xenorhabdus nematophila, inhibit a catalytic activity of phenoloxidase of the diamondback moth, Plutella xylostella
    Chrisitine Jisoo Song
    Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    J Microbiol Biotechnol 21:317-22. 2011
    ..nematophila also inhibited the PO enzyme activity. However, modification of the core structure by hydroxylation of BZA lost its strong inhibitory activity against the activated PO...
  99. doi High-resolution NMR spectroscopy in unstable and inhomogeneous fields via stroboscopic acquisition
    Meijin Lin
    Department of Physics, Fujian Key Laboratory of Plasma and Magnetic Resonance, State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen, China
    Spectrochim Acta A Mol Biomol Spectrosc 79:112-7. 2011
    ....
  100. doi Organocatalytic asymmetric direct aldol reactions of trifluoroacetaldehyde ethyl hemiacetal with aromatic methyl ketones
    Kazumasa Funabiki
    Department of Materials Science and Technology, Faculty of Engineering, Gifu University, 1 1 Yanagido, Gifu 501 1193, Japan
    J Org Chem 76:3545-50. 2011
    ..methyl ketones in the presence of a catalytic amount of (S)-5-(pyrrolidin-2-yl)-1H-tetrazole in dichloroethane at 40 °C proceeds smoothly to produce (R)-4,4,4-trifluoro-1-aryl-3-hydroxy-1-butanones in high yields with up to 90% ee.
  101. pmc Oxyallyl exposed: an open-shell singlet with picosecond lifetimes in solution but persistent in crystals of a cyclobutanedione precursor
    Gregory Kuzmanich
    Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095 1559, USA
    J Am Chem Soc 133:2342-5. 2011
    ..The electronic spectrum of the singlet biradical, confirmed by femtosecond pump-probe studies in solution, was matched by coupled cluster calculations with single and double corrections...

Research Grants70

  1. MOLECULAR MECHANISMS OF HEXACARBON-INDUCED AXON ATROPHY
    RICHARD LOPACHIN; Fiscal Year: 2007
    ..Understanding the role and mechanism of axon atrophy in solvent neurotoxicity has broad-based implications for human occupational health and risk assessment. ..
  2. NERVE TERMINAL AS A SITE OF ACRYLAMIDE ACTION
    RICHARD LOPACHIN; Fiscal Year: 2002
    ..Results could lead to a better understanding of acquired and inherited human neuropathies and the development of efficacious pharmacotherapies. ..
  3. The Nerve Terminal as a Site of Acrylamide Action
    RICHARD LOPACHIN; Fiscal Year: 2006
    ..Determining how these chemicals work will provide a rational basis for establishing occupational exposure conditions and for development of efficacious pharmacotherapeutic approaches. ..
  4. MOLECULAR MECHANISMS OF HEXACARBON-INDUCED AXON ATROPHY
    RICHARD LOPACHIN; Fiscal Year: 2003
    ..In addition, our studies might suggest novel pharmacotherapies based on neurotrophin intervention or replacement. ..
  5. The Nerve Terminal as the Site of Action for Type-2 Alkenes
    RICHARD LOPACHIN; Fiscal Year: 2009
    ....
  6. MOLECULAR MECHANISMS OF HEXACARBON-INDUCED AXON ATROPHY
    RICHARD LOPACHIN; Fiscal Year: 2009
    ..Understanding the role and mechanism of axon atrophy in solvent neurotoxicity has broad-based implications for human occupational health and risk assessment. ..
  7. The Nerve Terminal as the Site of Action for Type-2 Alkenes
    RICHARD MICHAEL LOPACHIN; Fiscal Year: 2010
    ....
  8. MOLECULAR MECHANISMS OF HEXACARBON INDUCED AXON ATROPHY
    RICHARD LOPACHIN; Fiscal Year: 1999
    ..In addition, this proposal might have broad-based implications for other toxic chemicals (acrylamide, carbon disulfide) and disease processes (diabetes) associated with axonal atrophy. ..
  9. Novel Approaches for Antitumor and Antiviral Agents
    Barry M Trost; Fiscal Year: 2010
    ..This proposal helps to address this key challenge by developing the underlying initial technology within classes of compounds having demonstrably antitumor or antiviral activities. ..
  10. Transforming Colorectal Cancer Screening through Multimodal Spectral Markers
    Vadim Backman; Fiscal Year: 2011
    ..Our approach is to develop a minimally intrusive, highly accurate pre-screen that would allow tailoring timing/intensity of screening and surveillance. ..
  11. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2006
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  12. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2007
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  13. Spectral Markers for Early Detection of Colon Neoplasia
    Hemant Roy; Fiscal Year: 2007
    ..In the future these spectral markers may be assayed with a 4D-ELF probe during rectal examination, thus providing a practical and accurate means of determining the optimal CRC screening regimen. ..
  14. Improving colonoscopic miss rate by real time microvascular blood analysis
    Hemant Roy; Fiscal Year: 2007
    ..This could have major importance for colon cancer prevention efforts in the United States. ..
  15. NOVEL APPROACHES TO ANTITUMOR AND ANTIVIRAL AGENTS
    BARRY TROST; Fiscal Year: 2007
    ..By expediting access to very diverse arrays of structural types, the best opportunities to discover new therapeutic agents arise. ..
  16. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  17. NOVEL APPROACHES TO ANTITUMOR AND ANTIVIRAL AGENTS
    BARRY TROST; Fiscal Year: 2004
    ..By accessing a very diverse range of structural types, the best opportunities to discover new therapeutic agents arise. ..
  18. NOVEL SYNTHETIC APPROACHES TO ANTITUMOR COMPOUNDS
    BARRY TROST; Fiscal Year: 1992
    ..A strategy to one family of tumor promoters represented by teleocidin explores the concept of chemical chameleons. In most cases, the strategy also considers the problem of absolute stereochemistry...
  19. NOVEL APPROACHES TO ANTITUMOR AND ANTIVIRAL AGENTS
    BARRY TROST; Fiscal Year: 1993
    ..The diversity of the challenges posed by antiviral and antitumor agents represent highly meaningful tests of their use...
  20. TSNA AND PANCREATIC CANCER
    Bogdan Prokopczyk; Fiscal Year: 2000
    ....
  21. NOVEL APPROACHES TO ANTITUMOR AND ANTIVIRAL AGENTS
    BARRY TROST; Fiscal Year: 2000
    ..Equally important, new avenues to vary structure around these cores in order to establish structure-activity relationships with the aim to create better therapeutic agents become available. ..
  22. Synthesis of Macrolides. Steroids, Cyclopentanoids, etc
    BARRY TROST; Fiscal Year: 2005
    ..This new concept sets the stage for solutions to a long standing problem, the ion channel blockers, the grayanotoxins. as well as the more recently discovered rameswaralide, a potent antiinflamatory. ..
  23. THE ROLE OF TOBACCO-SPECIFIC NITROSAMINES IN PANCREATIC CANCER
    Bogdan Prokopczyk; Fiscal Year: 2007
    ..The result of this study will further support the role of cigarette smoking and underscore the likelihood of dietary fat as a modulator of the development of human pancreatic cancer that is suggested by epidemiological observations. ..
  24. SYNTHESIS OF MACROCYCLES STEROIDS CYCLOPENTANOIDS ETC
    BARRY TROST; Fiscal Year: 2001
    ..Ring expansion methods may convert these cores into the taxoid skeleton with appropriate functionality at key points for analog development. ..
  25. Mixture Toxicity: Evaluation of an Improved Methodology
    DOUGLAS DAWSON; Fiscal Year: 2003
    ..Upon completion, the project should provide an answer as to whether there is a relationship between the type of combined effect obtained and the molecular site(s) of action of the agents. ..