phthalimides

Summary

Summary: The imide of phthalic acids.

Top Publications

  1. ncbi Light interacts with auxin during leaf elongation and leaf angle development in young corn seedlings
    Martin Fellner
    University of Washington, Department of Botany 355325, Seattle, WA 98195 5325, USA
    Planta 216:366-76. 2003
  2. ncbi Plant science. Auxin transport, but in which direction?
    Tobias Sieberer
    Department of Biology, University of York, York YO10 4YW, UK
    Science 312:858-60. 2006
  3. ncbi Discovery of two novel, small-molecule inhibitors of DNA methylation
    Pawel Siedlecki
    Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5A, 02 106 Warsaw, Poland
    J Med Chem 49:678-83. 2006
  4. ncbi Synthesis and hypolipidemic activity of N-substituted phthalimides. Part V
    Vera L M Sena
    Departamento de Quimica Fundamental, Universidade Federal de Pernambuco UFPE, Av Luis Freire, S N, Cidade Universitaria, CEP 50 740 540 Recife, PE, Brazil
    Farmaco 58:1283-8. 2003
  5. ncbi Synthesis and antiinflammatory activity of 4-amino-2-aryl-5-cyano-6-{3- and 4-(N-phthalimidophenyl)} pyrimidines
    Emerson Peter da S Falcão
    Departamento de Antibioticos, Universidade Federal de Pernambuco, 50 670 901 Recife, PE, Brazil
    Eur J Med Chem 41:276-82. 2006
  6. ncbi Synthesis and anti-inflammatory activity of N-phthalimidomethyl 2,3-dideoxy- and 2,3-unsaturated glycosides
    Xiang Bao Meng
    Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    Carbohydr Res 342:1169-74. 2007
  7. ncbi Transmembrane auxin carrier systems--dynamic regulators of polar auxin transport
    D A Morris
    Cell Sciences Division, School of Biological Sciences, University of Southampton, Southampton, UK
    Plant Growth Regul 32:161-72. 2000
  8. ncbi Synthesis of 4,5-dianilinophthalimide and related analogues for potential treatment of Alzheimer's disease via palladium-catalyzed amination
    Edward J Hennessy
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Org Chem 70:7371-5. 2005
  9. pmc Auxin transport promotes Arabidopsis lateral root initiation
    I Casimiro
    Departmento de Ciencias Morfologicas y Biologia Celular y Animal, University of Extremadura, Badajoz, Spain
    Plant Cell 13:843-52. 2001
  10. pmc Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs
    Huan Wang
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, 805b Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:7159-64. 2008

Research Grants

  1. Cerebrovascular Changes in Pregnancy and Hypertension
    Marilyn Cipolla; Fiscal Year: 2003
  2. REPERFUSION EFFECTS ON CEREBRAL ARTERY FUNCTION
    Marilyn Cipolla; Fiscal Year: 2000
  3. Cerebrovascular Changes in Pregnancy and Hypertension
    Marilyn Cipolla; Fiscal Year: 2009
  4. REPERFUSION EFFECTS ON CEREBRAL ARTERY FUNCTION
    Marilyn Cipolla; Fiscal Year: 2003
  5. Cerebrovascular Changes in Pregnancy and Hypertension
    Marilyn Cipolla; Fiscal Year: 2006
  6. REPERFUSION EFFECTS ON CEREBRAL ARTERY FUNCTION
    Marilyn Cipolla; Fiscal Year: 1999
  7. REPERFUSION EFFECTS ON CEREBRAL ARTERY FUNCTION
    Marilyn Cipolla; Fiscal Year: 2001
  8. REPERFUSION EFFECTS ON CEREBRAL ARTERY FUNCTION
    Marilyn Cipolla; Fiscal Year: 2002
  9. Cerebrovascular Changes in Pregnancy and Hypertension
    Marilyn J Cipolla; Fiscal Year: 2010
  10. Cerebral Arteriole Function during Hyperglycemic Stroke
    Marilyn Cipolla; Fiscal Year: 2008

Detail Information

Publications158 found, 100 shown here

  1. ncbi Light interacts with auxin during leaf elongation and leaf angle development in young corn seedlings
    Martin Fellner
    University of Washington, Department of Botany 355325, Seattle, WA 98195 5325, USA
    Planta 216:366-76. 2003
    ..The more erect leaves in 3394 may contribute to the tolerance of the modern corn hybrid to dense planting...
  2. ncbi Plant science. Auxin transport, but in which direction?
    Tobias Sieberer
    Department of Biology, University of York, York YO10 4YW, UK
    Science 312:858-60. 2006
  3. ncbi Discovery of two novel, small-molecule inhibitors of DNA methylation
    Pawel Siedlecki
    Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5A, 02 106 Warsaw, Poland
    J Med Chem 49:678-83. 2006
    ..The newly discovered inhibitors validate our screening procedure and also provide a useful basis for further rational drug development...
  4. ncbi Synthesis and hypolipidemic activity of N-substituted phthalimides. Part V
    Vera L M Sena
    Departamento de Quimica Fundamental, Universidade Federal de Pernambuco UFPE, Av Luis Freire, S N, Cidade Universitaria, CEP 50 740 540 Recife, PE, Brazil
    Farmaco 58:1283-8. 2003
    A series of N-aryl- or N-(1,2,4-triazol-yl)-phthalimides (4a-4i) have been synthesized starting from phthalic anhydride (1) and an appropriate amine (2a-2i)...
  5. ncbi Synthesis and antiinflammatory activity of 4-amino-2-aryl-5-cyano-6-{3- and 4-(N-phthalimidophenyl)} pyrimidines
    Emerson Peter da S Falcão
    Departamento de Antibioticos, Universidade Federal de Pernambuco, 50 670 901 Recife, PE, Brazil
    Eur J Med Chem 41:276-82. 2006
    ..7a-c have been found to be twice more active than aspirin. Cytotoxical evaluations of compounds 7a-e using neoplastic cells (NCI-H(292) and Hep-2) presented 41% of growth inhibition of neoplastic cells NCI-H(292)...
  6. ncbi Synthesis and anti-inflammatory activity of N-phthalimidomethyl 2,3-dideoxy- and 2,3-unsaturated glycosides
    Xiang Bao Meng
    Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    Carbohydr Res 342:1169-74. 2007
    ..Following deacetylation, the anti-inflammatory activities of these compounds were tested on mice and three were found to possess potent activity compared to hydrocortisone sodium succinate (HSS)...
  7. ncbi Transmembrane auxin carrier systems--dynamic regulators of polar auxin transport
    D A Morris
    Cell Sciences Division, School of Biological Sciences, University of Southampton, Southampton, UK
    Plant Growth Regul 32:161-72. 2000
    ..The way is now clear for the development of specific molecular probes with which to investigate the intracellular transport and targeting of auxin carrier proteins...
  8. ncbi Synthesis of 4,5-dianilinophthalimide and related analogues for potential treatment of Alzheimer's disease via palladium-catalyzed amination
    Edward J Hennessy
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Org Chem 70:7371-5. 2005
    ..Thus, a variety of DAPH analogues can be quickly accessed in a modular fashion. In addition, the route described herein should also be amenable to the incorporation of other classes of nucleophiles into the molecular framework...
  9. pmc Auxin transport promotes Arabidopsis lateral root initiation
    I Casimiro
    Departmento de Ciencias Morfologicas y Biologia Celular y Animal, University of Extremadura, Badajoz, Spain
    Plant Cell 13:843-52. 2001
    ....
  10. pmc Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs
    Huan Wang
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, 805b Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:7159-64. 2008
    ..Our studies provide mechanistic insights and reinvigorate hopes for small-molecule therapies that specifically disrupt intermolecular amyloid contacts...
  11. ncbi Sites and homeostatic control of auxin biosynthesis in Arabidopsis during vegetative growth
    K Ljung
    , Department of Forest Genetics and Plant Physiology, The Swedish University of Agricultural Sciences, , Sweden
    Plant J 28:465-74. 2001
    ..This indicates that leaves are not only important sources for IAA synthesis, but that normal leaf expansion depends on rigorous control of IAA homeostasis...
  12. pmc The control of storage xyloglucan mobilization in cotyledons of Hymenaea courbaril
    Henrique Pessoa dos Santos
    Seção de Fisiologia e Bioquímica de Plantas, Instituto de Botânica, CEP 01061 970, Sao Paulo, SP, Brazil
    Plant Physiol 135:287-99. 2004
    ..This is likely to increase the efficiency of carbon reserves utilization by the growing seedling in the understorey light conditions of the rain forest...
  13. ncbi Root cap specific expression of an endo-beta-1,4-D-glucanase (cellulase): a new marker to study root development in Arabidopsis
    Elena del Campillo
    Department of Cell Biology and Molecular Genetics, University of Maryland at College Park, College Park, MD 20742, USA
    Plant Mol Biol 56:309-23. 2004
    ..We propose that AtCel5, provides a new molecular marker to further analyze the process of root cap cell separation and a root cap specific promoter for targeting to the environment genes with beneficial properties for plant growth...
  14. pmc Interactions between auxin transport and the actin cytoskeleton in developmental polarity of Fucus distichus embryos in response to light and gravity
    Haiguo Sun
    Department of Biology, Wake Forest University, Winston Salem, North Carolina 27109 7325, USA
    Plant Physiol 135:266-78. 2004
    ..Together, these results indicate a role for auxin in the orientation of developmental polarity and suggest interactions between the actin cytoskeleton and auxin transport in F. distichus embryos...
  15. pmc Brassinosteroids interact with auxin to promote lateral root development in Arabidopsis
    Fang Bao
    Department of Botany and Plant Sciences and Center for Plant Cell Biology, University of California, Riverside, California 92521, USA
    Plant Physiol 134:1624-31. 2004
    ..Our observations indicate that BRs regulate auxin transport, providing a novel mechanism for hormonal interactions in plants and supporting the hypothesis that BRs promote lateral root development by increasing acropetal auxin transport...
  16. pmc The Relationship between auxin transport and maize branching
    Andrea Gallavotti
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Plant Physiol 147:1913-23. 2008
    ..Based on our results, we propose a general model for branching during maize inflorescence development...
  17. ncbi Developmental stages during the rooting of in-vitro-cultured Quercus robur shoots from material of juvenile and mature origin
    N Vidal
    Instituto de Investigaciones Agrobiologicas de Galicia, CSIC, Apartado 122, 15080 Santiago de Compostela, Spain
    Tree Physiol 23:1247-54. 2003
    ..Thus, although adult oak material (C shoots) is capable of responding to the initial stimulus of auxin during the adventitious rooting process, the endogenous IAA concentration is not the factor limiting rooting in adult material...
  18. ncbi Arabidopsis AtGSTF2 is regulated by ethylene and auxin, and encodes a glutathione S-transferase that interacts with flavonoids
    Aaron P Smith
    Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907 1165, USA
    Plant J 36:433-42. 2003
    ..Our results indicate that AtGSTF2 is involved not only in stress responses but also in development under normal growth conditions...
  19. pmc Auxin transport synchronizes the pattern of cell division in a tobacco cell line
    Prisca Campanoni
    Biologisches Institut II, Albert Ludwigs Universitat Freiburg, Schanzlestrasse 1, D 79104 Freiburg, Germany
    Plant Physiol 133:1251-60. 2003
    ..Our findings are discussed in the context of auxin transport as synchronizing signal in cell patterning...
  20. ncbi [Graviresponse in higher plants and its regulation in molecular bases: relevance to growth and development, and auxin polar transport in etiolated pea seedlings]
    Junichi Ueda
    College of Integrated Arts and Sciences, Osaka Prefecture University, Sakai, Osaka, Japan
    Biol Sci Space 17:116-25. 2003
    ..Based on the results of expression of PsPIN2 and PsAUX1 genes under various gravistimulations, a possible role of PsPIN2 and PsAUX1 genes for auxin polar transport in etiolated pea seedlings will be discussed...
  21. ncbi Flavonoid-related regulation of auxin accumulation in Agrobacterium tumefaciens-induced plant tumors
    Katja Schwalm
    Institut fur Botanik, Technische Universitat, Schnittspahnstrasse 3, 64287 Darmstadt, Germany
    Planta 218:163-78. 2003
    ..tumefaciens-induced tumors. This, in turn, triggers vigorous proliferation and vascularization of the tumor tissues and suppresses their further differentiation...
  22. pmc The polar auxin transport inhibitor N-1-naphthylphthalamic acid disrupts leaf initiation, KNOX protein regulation, and formation of leaf margins in maize
    Michael J Scanlon
    Department of Plant Biology, University of Georgia, Athens, GA 30602, USA
    Plant Physiol 133:597-605. 2003
    ..A model for L1-derived margin development in maize leaves is presented...
  23. ncbi Comparative effects of auxin transport inhibitors on rhizogenesis and mycorrhizal establishment of spruce seedlings inoculated with Laccaria bicolor
    Ana Rincon
    Unité Mixte de Recherches Interactions Arbres Microorganismes, INRA Centre de Nancy, 54280 Champenoux, France
    Tree Physiol 23:785-91. 2003
    ..We conclude that fungal IAA plays an important role in plant rhizogenesis and in the establishment of ectomycorrhizal symbiosis...
  24. ncbi Automorphosis of etiolated pea seedlings in space is simulated by a three-dimensional clinostat and the application of inhibitors of auxin polar transport
    Kensuke Miyamoto
    College of Integrated Arts and Sciences, Osaka Prefecture University, Sakai, Osaka, Japan
    Physiol Plant 123:467-74. 2005
    ....
  25. ncbi Cholodny-Went revisited: a role for jasmonate in gravitropism of rice coleoptiles
    Caroline Gutjahr
    Institut fur Biologie II, Albert Ludwigs Universitat Freiburg, Schänzlestr 1, 79104, Freiburg i Br, Germany
    Planta 222:575-85. 2005
    ..Moreover, a jasmonate-deficient rice mutant bends more slowly and later than the wild type. We discuss a role of jasmonate as modulator of auxin responsiveness in gravitropism...
  26. pmc Expression of gibberellin 20-oxidase1 (AtGA20ox1) in Arabidopsis seedlings with altered auxin status is regulated at multiple levels
    Isabel Desgagné-Penix
    Biology Department, University of Texas at San Antonio, San Antonio, Texas 78249, USA
    J Exp Bot 59:2057-70. 2008
    ..Thus results show that, in intact auxin- and auxin transport inhibitor-treated light-grown Arabidopsis seedlings, three other levels of regulation supersede the effects of auxin on AtGA20ox1...
  27. ncbi Arabidopsis P-glycoprotein19 participates in the inhibition of gravitropism by gravacin
    Marcela Rojas-Pierce
    Department of Botany and Plant Sciences, University of California, Riverside, Riverside, CA 92521, USA
    Chem Biol 14:1366-76. 2007
    ..Gravacin is an auxin transport inhibitor that inhibits PGPs, particularly PGP19, which can be used to further dissect the role of PGP19 without the inhibition of other auxin transporters, namely PIN proteins...
  28. pmc A role for IAA in the infection of Arabidopsis thaliana by Orobanche aegyptiaca
    Nurit Bar-Nun
    Department of Plant and Environmental Sciences, Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Ann Bot 101:261-5. 2008
    ..It is generally accepted that the direction of vascular continuity results from polar flow of auxin. Our hypothesis was that chemical disruptions of auxin transport and activity could influence the infection of the host by the parasite...
  29. pmc Mutations in Arabidopsis multidrug resistance-like ABC transporters separate the roles of acropetal and basipetal auxin transport in lateral root development
    Guosheng Wu
    Department of Botany, University of Wisconsin, Madison, WI 53706, USA
    Plant Cell 19:1826-37. 2007
    ....
  30. ncbi Saturated humidity accelerates lateral root development in rice (Oryza sativa L.) seedlings by increasing phloem-based auxin transport
    Tory Chhun
    Center for Supports to Research and Education Activities Isotope Division, Kobe University, Kobe, 657 8501 Japan
    J Exp Bot 58:1695-704. 2007
    ..It is proposed that high humidity conditions accelerate the phloem-based transport of IAA from the leaf to the root, resulting in an increase in the number of lateral roots...
  31. pmc Arabidopsis nucleolin affects plant development and patterning
    Jalean Joyanne Petricka
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520 8104, USA
    Plant Physiol 144:173-86. 2007
    ..Based on the range of auxin-related defects in parl1 mutants, we propose that auxin-dependent organ growth and patterning is highly sensitive to the efficiency of nucleolin-dependent ribosomal processing...
  32. ncbi Variation in indole-3-acetic acid transport and its relationship with growth in etiolated lupin hypocotyls
    Juana Inés López Nicolás
    Departamento de Biología Vegetal Fisiología Vegetal, Facultad de Biologia, Universidad de Murcia, Campus de Espinardo, 30100 Murcia, Spain
    J Plant Physiol 164:851-60. 2007
    ..These results suggest that a basipetally decreasing gradient in PAT along the hypocotyl, which changes with age, may be responsible for auxin distribution pattern controlling growth...
  33. pmc Molecular changes occurring during acquisition of abscission competence following auxin depletion in Mirabilis jalapa
    Shimon Meir
    Department of Postharvest Science of Fresh Produce, Agricultural Research Organization, The Volcani Center, Bet Dagan 50250, Israel
    Plant Physiol 141:1604-16. 2006
    ..Our results demonstrate a correlation between acquisition of competence to respond to ethylene in both leaf and stem AZs, and decline in abundance of auxin regulatory gene transcripts...
  34. ncbi STY1 regulates auxin homeostasis and affects apical-basal patterning of the Arabidopsis gynoecium
    Joel J Sohlberg
    Department of Plant Biology and Forest Genetics, Swedish University of Agricultural Sciences, Box 7080, S 750 07 Uppsala, Sweden
    Plant J 47:112-23. 2006
    ..Our results suggest that STY1 and related genes promote normal development of the style and affect apical-basal patterning of the gynoecium through regulation of auxin homeostasis...
  35. ncbi PIN proteins perform a rate-limiting function in cellular auxin efflux
    Jan Petrasek
    Institute of Experimental Botany, The Academy of Sciences of the Czech Republic, 165 02 Prague 6, Czech Republic
    Science 312:914-8. 2006
    ..This suggests a direct involvement of PINs in catalyzing cellular auxin efflux...
  36. ncbi The WAG1 and WAG2 protein kinases negatively regulate root waving in Arabidopsis
    Aaron A Santner
    Department of Biology, Indiana University Purdue University Indianapolis, 723 West Michigan Street, Indianapolis, IN 46202, USA
    Plant J 45:752-64. 2006
    ..Promoter fusions to the gusA reporter gene demonstrate that the WAG promoters are most active in root tips, consistent with the observed phenotypes in the wag mutants...
  37. ncbi Signals controlling root suckering and adventitious shoot formation in aspen (Populus tremuloides)
    Xianchong Wan
    Department of Renewable Resources, University of Alberta, Edmonton, Alberta, Canada T6G 2H1
    Tree Physiol 26:681-7. 2006
    ....
  38. ncbi Design, synthesis, and action of oxotremorine-related hybrid-type allosteric modulators of muscarinic acetylcholine receptors
    Teresa Disingrini
    Istituto di Chimica Farmaceutica e Tossicologica, Universita degli Studi di Milano, Viale Abruzzi 42, 20131 Milano, Italy
    J Med Chem 49:366-72. 2006
    ..Thus, attaching muscarinic allosteric antagonist moieties to orthosteric muscarinic agonists may lead to hybrid compounds in which functions of both components are mixed...
  39. pmc The rib1 mutant of Arabidopsis has alterations in indole-3-butyric acid transport, hypocotyl elongation, and root architecture
    Julie Poupart
    Department of Biology, McGill University, Montreal, Quebec, Canada
    Plant Physiol 139:1460-71. 2005
    ..Taken together, our results support a model in which endogenous IBA influences wild-type seedling morphology. Modifications in IBA distribution in seedlings affect hypocotyl and root elongation, as well as lateral root formation...
  40. pmc Polyamine oxidase, a hydrogen peroxide-producing enzyme, is up-regulated by light and down-regulated by auxin in the outer tissues of the maize mesocotyl
    Alessandra Cona
    Dipartimento di Biologia, Universita degli Studi Roma Tre, Viale Guglielmo Marconi 446, 00146 Rome, Italy
    Plant Physiol 131:803-13. 2003
    ..These results suggest that both light and auxin finely tune PAO expression during the light-induced differentiation of the cell wall in the maize mesocotyl epidermal tissues...
  41. pmc Do phytotropins inhibit auxin efflux by impairing vesicle traffic?
    Jan Petrasek
    Institute of Experimental Botany, The Academy of Sciences of the Czech Republic, Rozvojova 135, CZ 16502 Prague 6, Czech Republic
    Plant Physiol 131:254-63. 2003
    ..We found no evidence to support recent suggestions that the action of auxin transport inhibitors is mediated by a general inhibition of vesicle-mediated protein traffic to the plasma membrane...
  42. pmc Indole acetic acid distribution coincides with vascular differentiation pattern during Arabidopsis leaf ontogeny
    Orna Avsian-Kretchmer
    Department of Plant and Microbial Biology, University of California, 111 Koshland Hall, Berkeley, California 94720, USA
    Plant Physiol 130:199-209. 2002
    ..An outside IAA source for the SAM supports the notion that IAA transport and procambium differentiation dictate phyllotaxy and organogenesis...
  43. pmc Role of auxin-induced reactive oxygen species in root gravitropism
    J H Joo
    Center for Cell Signaling Research, Department of Biological Sciences, Ewha Womans University, Seoul 120-750, South Korea
    Plant Physiol 126:1055-60. 2001
    ..Furthermore, the scavenging of ROS by antioxidants (N-acetylcysteine, ascorbic acid, and Trolox) inhibited root gravitropism. These results indicate that the generation of ROS plays a role in root gravitropism...
  44. pmc Genetic and chemical reductions in protein phosphatase activity alter auxin transport, gravity response, and lateral root growth
    A M Rashotte
    Department of Biology, Wake Forest University, Winston Salem, NC 27109, USA
    Plant Cell 13:1683-97. 2001
    ..These results support the role of protein phosphorylation in regulating auxin transport and suggest that the acropetal and basipetal auxin transport streams are differentially regulated...
  45. pmc Alteration of auxin polar transport in the Arabidopsis ifl1 mutants
    R Zhong
    Department of Botany, University of Georgia, Athens, Georgia 30602, USA
    Plant Physiol 126:549-63. 2001
    ..Taken together, these results suggest a correlation between the reduced auxin polar transport and the alteration of cell differentiation and morphology in the ifl1 mutants...
  46. pmc Reorientation of seedlings in the earth's gravitational field induces cytosolic calcium transients
    Christoph Plieth
    Zentrum für Biochemie und Molekularbiologie, Christian Albrechts Universitat, Am Botanischen Garten 1 9 Room 517, D 24118 Kiel, Germany
    Plant Physiol 129:786-96. 2002
    ..It is concluded that [Ca(2+)](c) is part of the gravity transduction mechanism in young Arabidopsis seedlings...
  47. ncbi Regulation of polar auxin transport by AtPIN1 in Arabidopsis vascular tissue
    L Gälweiler
    Max Delbruck Laboratorium in der Max Planck Gesellschaft, Carl von Linne Weg 10, D 50829 Köln, Germany
    Science 282:2226-30. 1998
    ..AtPIN1 may act as a transmembrane component of the auxin efflux carrier...
  48. pmc The TIR1 protein of Arabidopsis functions in auxin response and is related to human SKP2 and yeast grr1p
    M Ruegger
    Department of Biology, Indiana University, Bloomington, Indiana 47405 USA
    Genes Dev 12:198-207. 1998
    ..Because Grr1p and other F-box proteins have been implicated in ubiquitin-mediated processes, we speculate that auxin response depends on the modification of a key regulatory protein(s) by ubiquitin or a ubiquitin-related protein...
  49. pmc The procambium specification gene Oshox1 promotes polar auxin transport capacity and reduces its sensitivity toward inhibition
    Enrico Scarpella
    Institute of Molecular Plant Sciences, Leiden University, Clusius Laboratory, P O Box 9505, 2300 RA Leiden, The Netherlands
    Plant Physiol 130:1349-60. 2002
    ....
  50. ncbi Genetic analysis of the effects of polar auxin transport inhibitors on root growth in Arabidopsis thaliana
    H Fujita
    Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Japan
    Plant Cell Physiol 37:1094-101. 1996
    ..thaliana, and (4) in contrast to NPA, TIBA itself has a weak auxin-like inhibitory effect...
  51. ncbi Effect of auxin transport inhibitors and ethylene on the wood anatomy of poplar
    U Junghans
    Forstbotanisches Institut, Georg August Universitat Gottingen, Gottingen, Germany
    Plant Biol (Stuttg) 6:22-9. 2004
    ....
  52. ncbi Inhibited polar auxin transport results in aberrant embryo development in Norway spruce
    Emma Larsson
    Department of Plant Biology and Forest Genetics, Swedish University of Agricultural Sciences, PO Box 7080, SE 75007 Uppsala, Sweden
    New Phytol 177:356-66. 2008
    ..This suggests that the role of polar auxin transport is conserved between angiosperms and gymnosperms...
  53. ncbi The ABC subfamily B auxin transporter AtABCB19 is involved in the inhibitory effects of N-1-naphthyphthalamic acid on the phototropic and gravitropic responses of Arabidopsis hypocotyls
    Akitomo Nagashima
    Genetic Regulatory Systems Research Team, RIKEN Plant Science Center, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa, 230 0045 Japan
    Plant Cell Physiol 49:1250-5. 2008
    ..These data thus suggest that AtABCB19 plays an important role in the inhibitory effects of NPA on hypocotyl tropism induced by auxin...
  54. ncbi Parallel synthesis and biological activity of a new class of high affinity and selective delta-opioid ligand
    D R Barn
    Organon Laboratories Ltd, Newhouse, ML1 5SH, Scotland, UK
    Bioorg Med Chem 9:2609-24. 2001
    ..v.)...
  55. pmc Phthalascidin, a synthetic antitumor agent with potency and mode of action comparable to ecteinascidin 743
    E J Martinez
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 96:3496-501. 1999
    ..The relationship of chemical structure and antitumor activity for this class of molecules has been clarified by this study...
  56. pmc Small-molecule aggregates inhibit amyloid polymerization
    Brian Y Feng
    Department of Pharmaceutical Chemistry and Graduate Group in Chemistry and Chemical Biology, University of California San Francisco, 1700 4th Street, San Francisco, California 94158 2330, USA
    Nat Chem Biol 4:197-9. 2008
    ..They also blocked infection of yeast cells with Sup35 prions, which suggests that colloidal inhibition may be relevant in more biological milieus...
  57. doi Aggregator compounds confound amyloid fibrillization assay
    Gilbert M Rishton
    Nat Chem Biol 4:159-60. 2008
  58. ncbi Newer N-phthaloyl GABA derivatives with antiallodynic and antihyperalgesic activities in both sciatic nerve and spinal nerve ligation models of neuropathic pain
    Perumal Yogeeswari
    Pharmacy Group, Birla Institute of Technology and Science, Pilani, Rajasthan, India
    Pharmacology 81:21-31. 2008
    ..Hence, the present study was undertaken to assess the peripheral analgesic, antiallodynic and antihyperalgesic activities of the synthesized structural analogues of GABA...
  59. doi Synthesis and anti-cancer activity of benzothiazole containing phthalimide on human carcinoma cell lines
    Stanton Hon Lung Kok
    Lo Ka Chung Centre for Natural Anti cancer Drug Development Laboratory B, Hong Kong Polytechnic University, Yuk Choi Road, Hung Hom, Kowloon, Hong Kong, China
    Bioorg Med Chem 16:3626-31. 2008
    ..We further demonstrated that both caspase-dependent and -independent pathways are involved in our novel benzothiazole containing phthalimide induced apoptosis on cancer cells...
  60. ncbi Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide
    Tomonori Yanagawa
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Bioorg Med Chem Lett 16:4748-51. 2006
    ..The structure-activity relationship for fluorine substitution was elucidated...
  61. ncbi Biological evaluation of some selected cyclic imides: mitochondrial effects and in vitro cytotoxicity
    Silvia Regina Tozato Prado
    Department of Biochemistry and Molecular Biology, Federal University of Parana, Curitiba, Parana, Brazil
    Z Naturforsch C 59:663-72. 2004
    Cyclic imides such as succinimides, maleimides, glutarimides, phthalimides and their derivatives contain an imide ring and a general structure -CO-N(R)-CO- that confers hydrophobicity and neutral characteristic...
  62. ncbi Determination of fungicides in natural waters using solid-phase microextraction and gas chromatography coupled with electron-capture and mass spectrometric detection
    D A Lambropoulou
    Department of Chemistry, University of Ioannina, Greece
    J Chromatogr A 893:143-56. 2000
    ..captan, folpet and captafol--belong to different classes of chemical compound (chloroanilines, sulphamides, phthalimides and oxazolidines) and are used mainly in agriculture and as antifouling paints...
  63. ncbi Conformationally restricted analogues of remoxipride as potential antipsychotic agents
    M H Norman
    Division of Organic Chemistry, Burroughs Wellcome Co, Research Triangle Park, North Carolina 27709
    J Med Chem 36:3417-23. 1993
    ..4, FLA-797) included 2,3-dihydro-4H-1,3-benzoxazin-4-ones, 2,3-dihydro-4H-1,3-benzthiazin-4-ones, phthalimides, 1-isoindolinones, 1,2-benzisothiazol-3(2H)-ones, and 1,2-benzisothiazol-3(2H)-one 1,1-dioxides...
  64. ncbi Synthesis and antimicrobial activity of new adamantane derivatives I
    A Orzeszko
    Agricultural University, Institute of Chemistry, Warszawa, Poland
    Acta Biochim Pol 47:87-94. 2000
    ..and trimellitic anhydride chloride appeared very useful for preparation of a number of N-substituted phthalimides. Antimicrobial activity of the newly obtained derivatives such as, for example, 4-(adamant-1-ylmethoxycarbonyl)-..
  65. ncbi Ruthenium-catalyzed carbonylation at ortho C-h bonds in aromatic amides leading to phthalimides: C-h bond activation utilizing a bidentate system
    Satoshi Inoue
    Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565 0871, Japan
    J Am Chem Soc 131:6898-9. 2009
    ..The complex 9 was isolated by the stoichiometric reaction of 1b and Ru(3)(CO)(12), in which 1b binds to one Ru atom in the expected N,N fashion and the carbonyl oxygen binds to the other Ru atom as an O donor...
  66. ncbi Decarbonylative cycloaddition of phthalimides with 1,3-dienes
    Kyohei Fujiwara
    Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615 8510, Japan
    Org Lett 12:4548-51. 2010
    The decarbonylative cycloadditions of phthalimides with 1,3-dienes were performed by using nickel catalyst. The reactions afford 3-vinyldihydroisoquinolones regioselectively with respect to both 1,3-dienes and phthalimides.
  67. ncbi Palladium-catalyzed double carbonylation reactions of o-dihaloarenes with amines in phosphonium salt ionic liquids
    Hong Cao
    Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario K1N 6N5, Canada
    Org Lett 12:4126-9. 2010
    ..with amines in phosphonium salt ionic liquids proceeds efficiently to give the corresponding N-substituted phthalimides. This process can tolerate a wide array of functional groups and affords products in excellent yields...
  68. ncbi Synthesis and anticancer activity of 5'-phthaloylnucleosides
    A Orzeszko
    Institute of Chemistry, Agricultural University, Warsaw, Poland
    Pharmazie 58:169-72. 2003
    A series of novel 5'-phthaloylnucleosides were synthesized via Mitsunobu reaction starting from AZT or 2'-deoxyadenosine and numerous phthalimides and their sulphur analogues-thioimides. Some of them showed significant anticancer activity.
  69. doi Enhanced therapeutic effect of LK-423 in treating experimentally induced colitis in rats when administered in colon delivery microcapsules
    Polona Smrdel
    Lek Pharmaceuticals, Verovskova 57, Ljubljana, Slovenia
    J Microencapsul 27:572-82. 2010
    ..These results demonstrate that LK-23 colon delivery microcapsules enhance the therapeutic efficacy of the drug and therefore appear to be a useful approach for treating various inflammatory diseases in the large intestine...
  70. pmc Gravity-stimulated changes in auxin and invertase gene expression in maize pulvinal cells
    Joanne C Long
    Department of Biology, Wake Forest University, Winston Salem, NC 27109, USA
    Plant Physiol 128:591-602. 2002
    ..Based on these results, a two-phase model describing possible relationships between gravitropic curvature, IAA redistribution, and Ivr2 expression is presented...
  71. pmc Dual inhibition of human rhinovirus 2A and 3C proteases by homophthalimides
    Q M Wang
    Infectious Diseases Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Antimicrob Agents Chemother 42:916-20. 1998
    ..On the basis of the current understanding of their enzyme inhibitory mechanism, homophthalimides, as a group of novel nonpeptidic antirhinovirus agents, merit further structure-action relationship studies...
  72. pmc Post-intoxication inhibition of botulinum neurotoxin serotype A within neurons by small-molecule, non-peptidic inhibitors
    Gordon Ruthel
    U S Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Frederick, MD 21702 USA
    Toxins (Basel) 3:207-17. 2011
    ..Taken together, the results indicate that competitive SMNPIs of BoNT/A light chain can be effective within neurons post-intoxication...
  73. ncbi CEP1612, a dipeptidyl proteasome inhibitor, induces p21WAF1 and p27KIP1 expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice
    J Sun
    Drug Discovery Program, H. Lee Moffitt Cancer Center and Research Institute, Department of Biochemistry and Molecular Biology, University of South Florida, Tampa 33612-9494, USA
    Cancer Res 61:1280-4. 2001
    ..The results suggest that CEP1612 is a promising candidate for further development as an anticancer drug and demonstrate the feasibility of using proteasome inhibitors as novel antitumor agents...
  74. doi Synthesis and in vitro cytotoxic evaluation of N-alkylbromo and N-alkylphthalimido-isatins
    Pardeep Singh
    Department of Chemistry, Guru Nanak Dev University, Amritsar 143005, India
    Bioorg Med Chem Lett 21:3017-20. 2011
    ..The active analogue IS-4 exhibited IC(50) values of 4.57, 10.90, 11.75, 12.40 and 54.20 μM against HeLa, PC-3, HCT-15, THP-1 and Colo-205, respectively...
  75. ncbi On the bioactive conformation of NAN-190 (1) and MP3022 (2), 5-HT(1A) receptor antagonists
    M H Paluchowska
    Departments of Medicinal Chemistry and New Drug Research, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    J Med Chem 42:4952-60. 1999
    ..Our present study provides support to the hypothesis that the bioactive conformation of 1, responsible for its postsynaptic 5-HT(1A) receptor antagonism, is an extended linear structure represented by 7...
  76. ncbi Frequency and relevance of positive patch tests to cyclohexylthiophthalimide, a new rubber allergen
    S Huygens
    Department of Dermatology, University Hospital K U Leuven, Kapucijnenvoer 33, 3000 Leuven, Belgium
    Eur J Dermatol 11:443-5. 2001
    ..The determination of the relevance of positive tests remains difficult, especially since little is known about the components of rubber products...
  77. doi Nickel-catalyzed decarbonylative alkylidenation of phthalimides with trimethylsilyl-substituted alkynes
    Takahiro Shiba
    Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615 8510, Japan
    J Am Chem Soc 135:13636-9. 2013
    We have developed a nickel-catalyzed transformation, in which phthalimides react with trimethylsilyl-substituted alkynes in the presence of Ni(0)/PMe3/MAD catalyst to provide isoindolinones...
  78. ncbi Central selective acetylcholinesterase inhibitor with neurotrophic activity: structure-activity relationships of TAK-147 and related compounds
    Y Ishihara
    Medicinal Chemistry Laboratories, Pharmaceutical Research Division, Takeda Chemical Industries, Ltd, 17 85, Jusohonmachi 2 chome, Yodogawaku, Osaka, 532 8686, Japan
    Curr Med Chem 7:341-54. 2000
    ..TAK-147 is now under clinical trial as a therapeutic drug for Alzheimer s disease. This article reviews design and structure-activity relationships of TAK-147 and related compounds. Preclinical pharmacology of TAK-147 is also summarized...
  79. ncbi Application of pharmacophore models for the design and synthesis of new anticonvulsant drugs
    Barbara Malawska
    Department of Pharmaceutical Chemistry, Jagiellonian University Medical College, Medyczna 9, 30 688 Krakow, Poland
    Mini Rev Med Chem 3:341-8. 2003
    ..A pharmacophore model for sodium channel blocking compounds, anticonvulsants with the phthalimide pharmacophore, a model for anticonvulsant semicarbazones, and a model for GABA uptake inhibitors are presented...
  80. ncbi Residue levels of captan and trichlorfon in field-treated kaki fruits, individual versus composite samples, and after household processing
    M L Fernandez-Cruz
    Departamento de Proteccion Vegetal, Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria INIA, Carretera de la Coruña Km 7 5, E 28040 Madrid, Spain
    Food Addit Contam 23:591-600. 2006
    ..Trichlorfon penetrates into the flesh in a proportion of 70% of the residue at the pre-harvest interval. Cooking resulted in a decrease of 27% of residue levels of trichlorfon...
  81. ncbi Immunohistochemical localization of IAA and ABP1 in strawberry shoot apexes during floral induction
    Zhi Xia Hou
    College of Food Science and Nutritional Engineering, China Agricultural University East campus, Beijing, 100083, China
    Planta 222:678-87. 2005
    ..Finally, an appropriate amount of IAA in the SAM and normal polar auxin transport are essential for floral induction and differentiation in strawberries...
  82. doi Liquid chromatography-tandem mass spectrometry (LC/APCI-MS/MS) methods for the quantification of captan and folpet phthalimide metabolites in human plasma and urine
    Aurélie Berthet
    Institute for Work and Health, Bugnon 21, 1011 Lausanne, Switzerland
    Anal Bioanal Chem 399:2243-55. 2011
    ..58 μg/L in urine and 1.47 μg/L in plasma for THPI and 1.14 and 2.17 μg/L, respectively, for PI. The described methods proved to be accurate and suitable to determine the toxicokinetics of both metabolites in human plasma and urine...
  83. ncbi Signaling-inactive epidermal growth factor receptor/ligand complexes in intact carcinoma cells by quinazoline tyrosine kinase inhibitors
    R B Lichtner
    Research Laboratories of Schering AG, 13342 Berlin, Germany
    Cancer Res 61:5790-5. 2001
    ..that compete with ATP at its binding site such as the quinazolines PD 153035 and ZD 1839 or the 4,5-dianilino-phthalimides DAPH1 and DAPH2...
  84. doi Hormonal interplay during adventitious root formation in flooded tomato plants
    Maria Laura Vidoz
    Plant Laboratory, Scuola Superiore Sant Anna, Via Mariscoglio 34, 56124 Pisa, Italy
    Plant J 63:551-62. 2010
    ..Auxin accumulation in the base of the plant induces growth of pre-formed root initials. This response of tomato plants results in a new root system that is capable of replacing the original one when it has been damaged by submergence...
  85. pmc Phosphonium lipocations as antiparasitic agents
    Timothy E Long
    Department of Pharmaceutical and Biomedical Sciences and Center for Drug Discovery, University of Georgia, Athens, GA 30602, USA
    Bioorg Med Chem Lett 22:2976-9. 2012
    ..Optimal phthalimides and 1,4-naphthoquinone-based lipocations were active in vitro at mid-high nM concentrations against P...
  86. pmc Overexpression of 3β-hydroxysteroid dehydrogenases/C-4 decarboxylases causes growth defects possibly due to abnormal auxin transport in Arabidopsis
    Bokyung Kim
    School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151 747, Korea
    Mol Cells 34:77-84. 2012
    ..Overexpression of the two Arabidopsis 3βHSD/D genes thus appears to affect auxin transporter activity, possibly by altering sterol composition in the membranes...
  87. ncbi 4,5-dianilinophtalimide protects neuroendocrine cells against serum deprivation-induced stress and apoptosis
    Volkan Ergin
    Department of Medical Biology and Genetics, Faculty of Medicine, Gazi University, Ankara, Turkey
    Neuro Endocrinol Lett 34:359-65. 2013
    ..The aim of this study was to reveal the effects of 4,5-dianilinophthalimide (DAPH), which inhibits amyloid β fibrillization, against serum deprivation (SD)-induced apoptosis and the possible mechanisms in differentiated PC12 neuron cells...
  88. doi Novel sulfanylphthalimide analogues as highly potent inhibitors of monoamine oxidase B
    Mietha M van der Walt
    Pharmaceutical Chemistry, School of Pharmacy, North West University, Private Bag X6001, Potchefstroom 2520, South Africa
    Bioorg Med Chem Lett 22:6632-5. 2012
    ..We conclude that 5-sulfanylphthalimides represent an interesting class of MAO-B inhibitors and may serve as lead compounds for the design of antiparkinsonian therapy...
  89. pmc Preformulation study of NSC-726796
    Duoli Guo
    College of Pharmacy, University of Arizona, Tucson, Arizona 85721, USA
    AAPS PharmSciTech 13:661-73. 2012
    ..The parent drug, NSC-726796, was also found to react with methanol and ethanol. NSC-726796 demonstrates antiangiogenic activity, however, when its degradant NSC749820 does not show antiangiogenic activity...
  90. doi Computing the inhomogeneous broadening of electronic transitions in solution: a first-principle quantum mechanical approach
    Francisco José Avila Ferrer
    University of Malaga, Physical Chemistry, Faculty of Science, Malaga, 29071, Spain
    Phys Chem Chem Phys 13:17007-12. 2011
    ..Thanks to these achievements, for the first time fully ab initio vibrationally resolved absorption spectra in solution are computed, obtaining spectra for coumarin C153 in remarkable agreement with experiments...
  91. pmc Copper complexes of anionic nitrogen ligands in the amidation and imidation of aryl halides
    Jesse W Tye
    Departments of Chemistry, University of Illinois, Urbana, Illinois 61801, USA
    J Am Chem Soc 130:9971-83. 2008
    ..Instead, these data are more consistent with mechanisms involving cleavage of the carbon-halogen bond within the coordination sphere of the metal...
  92. doi Non-competitive and selective dipeptidyl peptidase IV inhibitors with phenethylphenylphthalimide skeleton derived from thalidomide-related α-glucosidase inhibitors and liver X receptor antagonists
    Kazunori Motoshima
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Tokyo 113 0032, Japan
    Bioorg Med Chem Lett 21:3041-5. 2011
    ..Representative compounds showed non-competitive inhibition of DPP-IV and 28a exhibited 10-fold selectivity for DPP-IV over DPP-8. Compound 28a is the first non-competitive, selective DPP-IV inhibitor...
  93. doi A highly selective ratiometric fluorescent probe for 1,4-dithiothreitol (DTT) detection
    Baocun Zhu
    Department of Chemistry, School of Science, Beijing Institute of Technology, Beijing 100081, P R China
    Org Biomol Chem 8:1650-4. 2010
    ..The probe displays a 66 nm red-shift of fluorescence emission and the color changes from colorless to jade-green upon reaction with DTT. These properties are mechanistically ascribed to the strong reducing capability of DTT...
  94. doi Analysis of captan, folpet, and captafol in apples by dispersive liquid-liquid microextraction combined with gas chromatography
    Xiaohuan Zang
    Key Laboratory of Bioinorganic Chemistry, College of Science, Agricultural University of Hebei, Baoding, 071001, China
    Anal Bioanal Chem 392:749-54. 2008
    ..9982 to 0.9997. The obtained results show that the DLLME combined with GC-ECD can satisfy the requirements for the determination of fungicides in apple samples...
  95. doi Toxic pollutants emitted from thermal decomposition of phthalimide compounds
    Kai Chen
    Process Safety and Environmental Protection Research Group, School of Engineering, The University of Newcastle, Callaghan, New South Wales 2308, Australia
    J Hazard Mater 187:407-12. 2011
    ..The oxidation of THPI produced 2-cyclohexen-1-one, a toxic unsaturated ketone. The results of the present study provide the data for quantitative risk assessments of emissions of toxicants in combustion processes involving PI and THPI...
  96. doi Involvement of auxin distribution in root nodule development of Lotus japonicus
    Kojiro Takanashi
    Research Institute for Sustainable Humanosphere, Kyoto University, Gokasho, Uji 611 0011, Japan
    Planta 234:73-81. 2011
    ..The inhibition of lenticel formation was correlated with the inhibition of nodule vascular bundle development. These results indicate that auxin is required for the normal development of determinate nodules in a multidirectional manner...
  97. ncbi Nickel-mediated decarbonylative cross-coupling of phthalimides with in situ generated diorganozinc reagents
    Sarah E Havlik
    Department of Chemistry, Hope College, Holland, Michigan 49423, USA
    J Org Chem 76:3588-93. 2011
    The nickel-mediated cross-coupling of phthalimides with diorganozinc reagents proceeds via a decarbonylative process to produce ortho-substituted benzamides in high yields...
  98. doi Electroreductive intramolecular coupling of phthalimides with aromatic aldehydes: application to the synthesis of lennoxamine
    Naoki Kise
    Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4 101, Koyama cho Minami, Tottori 680 8552, Japan
    J Org Chem 76:9856-60. 2011
    The electroreductive intramolecular coupling of phthalimides with aromatic aldehydes in the presence of chlorotrimethylsilane and triethylamine led to five-, six-, and seven-membered cyclized products (58-84%)...
  99. doi Soccer-related facial fractures: postoperative management with facial protective shields
    Pasquale Procacci
    Department of Maxillo Facial Surgery and Dentistry, University of Verona, Verona, Italy
    J Craniofac Surg 20:15-20. 2009
    ..This article describes a clinical experience of management of 4 soccer-related facial fractures by means of fabrication of individual facial protective shields...
  100. ncbi Arabidopsis cryptochrome-1 restrains lateral roots growth by inhibiting auxin transport
    Jianxin Zeng
    Bioenergy and Biomaterial Research Center, Bioscience and Biotechnology Institute, Hunan University, Changsha 410082, China
    J Plant Physiol 167:670-3. 2010
    ..Taken together, these results suggest that Arabidopsis CRY1 restrains lateral roots growth by inhibiting auxin transport...
  101. doi New heteroannulation reactions of N-alkoxybenzamides by Pd(II) catalyzed C-H activation
    Joe W Wrigglesworth
    School of Chemistry, University of Bristol, Cantock s Close, Bristol, BS8 1TS, UK
    Org Lett 13:5326-9. 2011
    ..Modification of the reaction conditions provides a general route to substituted phthalimides by carbonylation with CO. Both systems were found to tolerate a wide range of functionality.

Research Grants49

  1. Cerebrovascular Changes in Pregnancy and Hypertension
    Marilyn Cipolla; Fiscal Year: 2003
    ..The influence of pregnancy on permeability during forced dilatation will be determined using a combination of techniques, including clearance of fluorescent tracers and transmission electron microscopy. ..
  2. REPERFUSION EFFECTS ON CEREBRAL ARTERY FUNCTION
    Marilyn Cipolla; Fiscal Year: 2000
    ..Therefore, Aim 3 will investigate the effects of two types of thrombolytic agents (tissue-type and urokinase) on cerebral artery function, including myogenic processes. ..
  3. Cerebrovascular Changes in Pregnancy and Hypertension
    Marilyn Cipolla; Fiscal Year: 2009
    ..This understanding is crucial to effective management and treatment of this devastating condition. ..
  4. REPERFUSION EFFECTS ON CEREBRAL ARTERY FUNCTION
    Marilyn Cipolla; Fiscal Year: 2003
    ..Therefore, Aim 3 will investigate the effects of two types of thrombolytic agents (tissue-type and urokinase) on cerebral artery function, including myogenic processes. ..
  5. Cerebrovascular Changes in Pregnancy and Hypertension
    Marilyn Cipolla; Fiscal Year: 2006
    ..The influence of pregnancy on permeability during forced dilatation will be determined using a combination of techniques, including clearance of fluorescent tracers and transmission electron microscopy. [unreadable] [unreadable]..
  6. REPERFUSION EFFECTS ON CEREBRAL ARTERY FUNCTION
    Marilyn Cipolla; Fiscal Year: 1999
    ..Therefore, Aim 3 will investigate the effects of two types of thrombolytic agents (tissue-type and urokinase) on cerebral artery function, including myogenic processes. ..
  7. REPERFUSION EFFECTS ON CEREBRAL ARTERY FUNCTION
    Marilyn Cipolla; Fiscal Year: 2001
    ..Therefore, Aim 3 will investigate the effects of two types of thrombolytic agents (tissue-type and urokinase) on cerebral artery function, including myogenic processes. ..
  8. REPERFUSION EFFECTS ON CEREBRAL ARTERY FUNCTION
    Marilyn Cipolla; Fiscal Year: 2002
    ..Therefore, Aim 3 will investigate the effects of two types of thrombolytic agents (tissue-type and urokinase) on cerebral artery function, including myogenic processes. ..
  9. Cerebrovascular Changes in Pregnancy and Hypertension
    Marilyn J Cipolla; Fiscal Year: 2010
    ..This understanding is crucial to effective management and treatment of this devastating condition. ..
  10. Cerebral Arteriole Function during Hyperglycemic Stroke
    Marilyn Cipolla; Fiscal Year: 2008
    ....
  11. Cerebral Arteriole Function during Hyperglycemic Stroke
    Marilyn Cipolla; Fiscal Year: 2007
    ....
  12. Cerebrovascular Changes in Pregnancy and Hypertension
    Marilyn Cipolla; Fiscal Year: 2009
    ..This understanding is crucial to effective management and treatment of this devastating condition. ..
  13. Cerebrovascular Changes in Pregnancy and Hypertension
    Marilyn J Cipolla; Fiscal Year: 2010
    ..This understanding is crucial to effective management and treatment of this devastating condition. ..
  14. Cerebral Arteriole Function during Hyperglycemic Stroke
    Marilyn Cipolla; Fiscal Year: 2009
    ....
  15. Cerebral Arteriole Function during Hyperglycemic Stroke
    Marilyn Cipolla; Fiscal Year: 2005
    ....
  16. Cerebrovascular Changes in Pregnancy and Hypertension
    Marilyn Cipolla; Fiscal Year: 2004
    ..The influence of pregnancy on permeability during forced dilatation will be determined using a combination of techniques, including clearance of fluorescent tracers and transmission electron microscopy. ..
  17. Cerebrovascular Changes in Pregnancy and Hypertension
    Marilyn Cipolla; Fiscal Year: 2005
    ..The influence of pregnancy on permeability during forced dilatation will be determined using a combination of techniques, including clearance of fluorescent tracers and transmission electron microscopy. ..
  18. Cerebral Arteriole Function during Hyperglycemic Stroke
    Marilyn Cipolla; Fiscal Year: 2006
    ....
  19. Purification of Optically Labeled Oligonucleotides
    William Pearson; Fiscal Year: 2004
    ..Initial work will focus on oligonucleotide probe purification. ..
  20. Self-Assembled Solutions to Asymmetric Hydrogenation
    JAMES TAKACS; Fiscal Year: 2005
    ....
  21. Purification of Oligonucleotides and Nucleoside Triphosphates
    William Pearson; Fiscal Year: 2007
    ..The proposed work seeks to further develop an entirely new method for oligonucleotide purification, thus streamlining the development and production of these crucial substances. [unreadable] [unreadable] [unreadable]..
  22. TRANSITION METAL CATALYZED C-C BONDING FORMING REACTION
    JAMES TAKACS; Fiscal Year: 2002
    ..Each application is designed to push the limits of the metal-mediated cyclization methodology, and as such will require targeted developmental work to be successful. ..
  23. ALKALOID SYNTHESIS VIA (3+2) CYCLOADDITIONS
    William Pearson; Fiscal Year: 2002
    ..Tandem processes that involve the combination of (3+2) cycloaddition followed by additional reactions that lead to a second or third ring formation or a rearrangement are also being studied. ..
  24. TRANSITION METAL CATALYZED C-C BONDING FORMING REACTION
    JAMES TAKACS; Fiscal Year: 2001
    ..Each application is designed to push the limits of the metal-mediated cyclization methodology, and as such will require targeted developmental work to be successful. ..
  25. NOVEL GLYCOSIDASE INHIBITORS AS ANTICANCER AGENTS
    William Pearson; Fiscal Year: 2001
    ..g., affinity matrices). ..
  26. NOVEL GLYCOSIDASE INHIBITORS AS ANTICANCER AGENTS
    William Pearson; Fiscal Year: 1999
    ..g., affinity matrices). ..
  27. TRANSITION METAL CATALYZED C-C BONDING FORMING REACTION
    JAMES TAKACS; Fiscal Year: 1999
    ..Each application is designed to push the limits of the metal-mediated cyclization methodology, and as such will require targeted developmental work to be successful. ..
  28. METAL CATALYZED CARBON - CARBON BOND FORMING REACTIONS
    JAMES TAKACS; Fiscal Year: 1992
    ..Part 4 describes investigations into defining other new, but mechanistically related, carbocyclization reactions...
  29. ALKALOID SYNTHESIS VIA (3+2) CYCLOADDITIONS
    William Pearson; Fiscal Year: 2001
    ..Tandem processes that involve the combination of (3+2) cycloaddition followed by additional reactions that lead to a second or third ring formation or a rearrangement are also being studied. ..
  30. TRANSITION METAL CATALYZED C-C BONDING FORMING REACTION
    JAMES TAKACS; Fiscal Year: 2000
    ..Each application is designed to push the limits of the metal-mediated cyclization methodology, and as such will require targeted developmental work to be successful. ..
  31. NOVEL GLYCOSIDASE INHIBITORS AS ANTICANCER AGENTS
    William Pearson; Fiscal Year: 2000
    ..g., affinity matrices). ..
  32. ALKALOID SYNTHESIS VIA (3+2) CYCLOADDITIONS
    William Pearson; Fiscal Year: 2000
    ..Tandem processes that involve the combination of (3+2) cycloaddition followed by additional reactions that lead to a second or third ring formation or a rearrangement are also being studied. ..
  33. ALKALOID SYNTHESIS VIA 2-AZAALLYL ANION CYCLOADDITIONS
    William Pearson; Fiscal Year: 1999
    ..The issue of stereocontrol, both absolute and relative is to be explored in detail. Information on the preferred transition state for these cycloadditions is to obtained as a result of these studies. ..
  34. METAL CATALYZED CARBON - CARBON BOND FORMING REACTIONS
    JAMES TAKACS; Fiscal Year: 1993
    ..Part 4 describes investigations into defining other new, but mechanistically related, carbocyclization reactions...
  35. METAL CATALYZED CARBON-CARBON FORMING REACTIONS
    JAMES TAKACS; Fiscal Year: 1990
    ....
  36. Diversity oriented combinational synthesis of bisheterocyclic libraries
    Viktor Krchnak; Fiscal Year: 2007
    ..3. Library submission: to format and organize compounds in a ready-to-test format according to the recommendation of the NIH Small-Molecule Repository and to prepare compound and reaction databases. ..
  37. Diversity oriented combinational synthesis of bisheterocyclic libraries
    Viktor Krchnak; Fiscal Year: 2008
    ..3. Library submission: to format and organize compounds in a ready-to-test format according to the recommendation of the NIH Small-Molecule Repository and to prepare compound and reaction databases. ..