phthalimides

Summary

Summary: The imide of phthalic acids.

Top Publications

  1. ncbi Light interacts with auxin during leaf elongation and leaf angle development in young corn seedlings
    Martin Fellner
    University of Washington, Department of Botany 355325, Seattle, WA 98195 5325, USA
    Planta 216:366-76. 2003
  2. ncbi Discovery of two novel, small-molecule inhibitors of DNA methylation
    Pawel Siedlecki
    Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5A, 02 106 Warsaw, Poland
    J Med Chem 49:678-83. 2006
  3. ncbi Inhibition of protein kinase C β(2) prevents tumor necrosis factor-α-induced apoptosis and oxidative stress in endothelial cells: the role of NADPH oxidase subunits
    Bingqing Deng
    Department of Cardiology, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, Guangzhou, PR China
    J Vasc Res 49:144-59. 2012
  4. ncbi Plant science. Auxin transport, but in which direction?
    Tobias Sieberer
    Department of Biology, University of York, York YO10 4YW, UK
    Science 312:858-60. 2006
  5. ncbi Design and optimization of tricyclic phtalimide analogues as novel inhibitors of HIV-1 integrase
    Wim G Verschueren
    Tibotec BVBA, Generaal de Wittelaan L 11B 3, B 2800 Mechelen, Belgium
    J Med Chem 48:1930-40. 2005
  6. ncbi Role of protein kinase C beta2 activation in TNF-alpha-induced human vascular endothelial cell apoptosis
    Fang Wang
    Anesthesiology Research Laboratory, Renmin Hospital, Wuhan University, Wuhan, Hubei, China
    Can J Physiol Pharmacol 87:221-9. 2009
  7. ncbi Synthesis and hypolipidemic activity of N-substituted phthalimides. Part V
    Vera L M Sena
    Departamento de Quimica Fundamental, Universidade Federal de Pernambuco UFPE, Av Luis Freire, S N, Cidade Universitaria, CEP 50 740 540 Recife, PE, Brazil
    Farmaco 58:1283-8. 2003
  8. ncbi Synthesis of N-sugar-substituted phthalimides and their derivatives from sugar azides and phthalic anhydride
    Su Na Zhang
    Department of Chemical Biology, School of Pharmaceutical Sciences, National Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China
    Carbohydr Res 339:1419-20. 2004
  9. pmc Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs
    Huan Wang
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, 805b Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:7159-64. 2008
  10. ncbi Synthesis of 4,5-dianilinophthalimide and related analogues for potential treatment of Alzheimer's disease via palladium-catalyzed amination
    Edward J Hennessy
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Org Chem 70:7371-5. 2005

Detail Information

Publications196 found, 100 shown here

  1. ncbi Light interacts with auxin during leaf elongation and leaf angle development in young corn seedlings
    Martin Fellner
    University of Washington, Department of Botany 355325, Seattle, WA 98195 5325, USA
    Planta 216:366-76. 2003
    ..The more erect leaves in 3394 may contribute to the tolerance of the modern corn hybrid to dense planting...
  2. ncbi Discovery of two novel, small-molecule inhibitors of DNA methylation
    Pawel Siedlecki
    Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5A, 02 106 Warsaw, Poland
    J Med Chem 49:678-83. 2006
    ..The newly discovered inhibitors validate our screening procedure and also provide a useful basis for further rational drug development...
  3. ncbi Inhibition of protein kinase C β(2) prevents tumor necrosis factor-α-induced apoptosis and oxidative stress in endothelial cells: the role of NADPH oxidase subunits
    Bingqing Deng
    Department of Cardiology, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, Guangzhou, PR China
    J Vasc Res 49:144-59. 2012
    ..Upregulation of expression of NADPH subunits is important in this process, which leads to a new target in antioxidative therapy for vascular disease prevention...
  4. ncbi Plant science. Auxin transport, but in which direction?
    Tobias Sieberer
    Department of Biology, University of York, York YO10 4YW, UK
    Science 312:858-60. 2006
  5. ncbi Design and optimization of tricyclic phtalimide analogues as novel inhibitors of HIV-1 integrase
    Wim G Verschueren
    Tibotec BVBA, Generaal de Wittelaan L 11B 3, B 2800 Mechelen, Belgium
    J Med Chem 48:1930-40. 2005
    ....
  6. ncbi Role of protein kinase C beta2 activation in TNF-alpha-induced human vascular endothelial cell apoptosis
    Fang Wang
    Anesthesiology Research Laboratory, Renmin Hospital, Wuhan University, Wuhan, Hubei, China
    Can J Physiol Pharmacol 87:221-9. 2009
    ..CGP53353, but not rottlerin, abolished or attenuated all these changes. We conclude that PKCbeta(2) plays a major role in TNF-alpha-induced human vascular endothelial cell apoptosis...
  7. ncbi Synthesis and hypolipidemic activity of N-substituted phthalimides. Part V
    Vera L M Sena
    Departamento de Quimica Fundamental, Universidade Federal de Pernambuco UFPE, Av Luis Freire, S N, Cidade Universitaria, CEP 50 740 540 Recife, PE, Brazil
    Farmaco 58:1283-8. 2003
    A series of N-aryl- or N-(1,2,4-triazol-yl)-phthalimides (4a-4i) have been synthesized starting from phthalic anhydride (1) and an appropriate amine (2a-2i)...
  8. ncbi Synthesis of N-sugar-substituted phthalimides and their derivatives from sugar azides and phthalic anhydride
    Su Na Zhang
    Department of Chemical Biology, School of Pharmaceutical Sciences, National Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China
    Carbohydr Res 339:1419-20. 2004
    N-Sugar-substituted phthalimides and tetrachlorophthalimide derivatives can be prepared in good yields under essentially neutral conditions...
  9. pmc Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs
    Huan Wang
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, 805b Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:7159-64. 2008
    ..Our studies provide mechanistic insights and reinvigorate hopes for small-molecule therapies that specifically disrupt intermolecular amyloid contacts...
  10. ncbi Synthesis of 4,5-dianilinophthalimide and related analogues for potential treatment of Alzheimer's disease via palladium-catalyzed amination
    Edward J Hennessy
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Org Chem 70:7371-5. 2005
    ..Thus, a variety of DAPH analogues can be quickly accessed in a modular fashion. In addition, the route described herein should also be amenable to the incorporation of other classes of nucleophiles into the molecular framework...
  11. pmc Auxin transport promotes Arabidopsis lateral root initiation
    I Casimiro
    Departmento de Ciencias Morfologicas y Biologia Celular y Animal, University of Extremadura, Badajoz, Spain
    Plant Cell 13:843-52. 2001
    ....
  12. ncbi Synthesis and antiinflammatory activity of 4-amino-2-aryl-5-cyano-6-{3- and 4-(N-phthalimidophenyl)} pyrimidines
    Emerson Peter da S Falcão
    Departamento de Antibioticos, Universidade Federal de Pernambuco, 50 670 901 Recife, PE, Brazil
    Eur J Med Chem 41:276-82. 2006
    ..7a-c have been found to be twice more active than aspirin. Cytotoxical evaluations of compounds 7a-e using neoplastic cells (NCI-H(292) and Hep-2) presented 41% of growth inhibition of neoplastic cells NCI-H(292)...
  13. ncbi Transmembrane auxin carrier systems--dynamic regulators of polar auxin transport
    D A Morris
    Cell Sciences Division, School of Biological Sciences, University of Southampton, Southampton, UK
    Plant Growth Regul 32:161-72. 2000
    ..The way is now clear for the development of specific molecular probes with which to investigate the intracellular transport and targeting of auxin carrier proteins...
  14. ncbi Synthesis and anti-inflammatory activity of N-phthalimidomethyl 2,3-dideoxy- and 2,3-unsaturated glycosides
    Xiang Bao Meng
    Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    Carbohydr Res 342:1169-74. 2007
    ..Following deacetylation, the anti-inflammatory activities of these compounds were tested on mice and three were found to possess potent activity compared to hydrocortisone sodium succinate (HSS)...
  15. ncbi Sites and homeostatic control of auxin biosynthesis in Arabidopsis during vegetative growth
    K Ljung
    , Department of Forest Genetics and Plant Physiology, The Swedish University of Agricultural Sciences, , Sweden
    Plant J 28:465-74. 2001
    ..This indicates that leaves are not only important sources for IAA synthesis, but that normal leaf expansion depends on rigorous control of IAA homeostasis...
  16. ncbi The WAG1 and WAG2 protein kinases negatively regulate root waving in Arabidopsis
    Aaron A Santner
    Department of Biology, Indiana University Purdue University Indianapolis, 723 West Michigan Street, Indianapolis, IN 46202, USA
    Plant J 45:752-64. 2006
    ..Promoter fusions to the gusA reporter gene demonstrate that the WAG promoters are most active in root tips, consistent with the observed phenotypes in the wag mutants...
  17. ncbi Automorphosis of etiolated pea seedlings in space is simulated by a three-dimensional clinostat and the application of inhibitors of auxin polar transport
    Kensuke Miyamoto
    College of Integrated Arts and Sciences, Osaka Prefecture University, Sakai, Osaka, Japan
    Physiol Plant 123:467-74. 2005
    ....
  18. pmc Arabidopsis nucleolin affects plant development and patterning
    Jalean Joyanne Petricka
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520 8104, USA
    Plant Physiol 144:173-86. 2007
    ..Based on the range of auxin-related defects in parl1 mutants, we propose that auxin-dependent organ growth and patterning is highly sensitive to the efficiency of nucleolin-dependent ribosomal processing...
  19. ncbi Saturated humidity accelerates lateral root development in rice (Oryza sativa L.) seedlings by increasing phloem-based auxin transport
    Tory Chhun
    Center for Supports to Research and Education Activities Isotope Division, Kobe University, Kobe, 657 8501 Japan
    J Exp Bot 58:1695-704. 2007
    ..It is proposed that high humidity conditions accelerate the phloem-based transport of IAA from the leaf to the root, resulting in an increase in the number of lateral roots...
  20. pmc Polyamine oxidase, a hydrogen peroxide-producing enzyme, is up-regulated by light and down-regulated by auxin in the outer tissues of the maize mesocotyl
    Alessandra Cona
    Dipartimento di Biologia, Universita degli Studi Roma Tre, Viale Guglielmo Marconi 446, 00146 Rome, Italy
    Plant Physiol 131:803-13. 2003
    ..These results suggest that both light and auxin finely tune PAO expression during the light-induced differentiation of the cell wall in the maize mesocotyl epidermal tissues...
  21. ncbi Cholodny-Went revisited: a role for jasmonate in gravitropism of rice coleoptiles
    Caroline Gutjahr
    Institut fur Biologie II, Albert Ludwigs Universitat Freiburg, Schänzlestr 1, 79104, Freiburg i Br, Germany
    Planta 222:575-85. 2005
    ..Moreover, a jasmonate-deficient rice mutant bends more slowly and later than the wild type. We discuss a role of jasmonate as modulator of auxin responsiveness in gravitropism...
  22. pmc Mutations in Arabidopsis multidrug resistance-like ABC transporters separate the roles of acropetal and basipetal auxin transport in lateral root development
    Guosheng Wu
    Department of Botany, University of Wisconsin, Madison, WI 53706, USA
    Plant Cell 19:1826-37. 2007
    ....
  23. pmc Do phytotropins inhibit auxin efflux by impairing vesicle traffic?
    Jan Petrasek
    Institute of Experimental Botany, The Academy of Sciences of the Czech Republic, Rozvojova 135, CZ 16502 Prague 6, Czech Republic
    Plant Physiol 131:254-63. 2003
    ..We found no evidence to support recent suggestions that the action of auxin transport inhibitors is mediated by a general inhibition of vesicle-mediated protein traffic to the plasma membrane...
  24. pmc The procambium specification gene Oshox1 promotes polar auxin transport capacity and reduces its sensitivity toward inhibition
    Enrico Scarpella
    Institute of Molecular Plant Sciences, Leiden University, Clusius Laboratory, P O Box 9505, 2300 RA Leiden, The Netherlands
    Plant Physiol 130:1349-60. 2002
    ....
  25. pmc A role for IAA in the infection of Arabidopsis thaliana by Orobanche aegyptiaca
    Nurit Bar-Nun
    Department of Plant and Environmental Sciences, Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Ann Bot 101:261-5. 2008
    ..It is generally accepted that the direction of vascular continuity results from polar flow of auxin. Our hypothesis was that chemical disruptions of auxin transport and activity could influence the infection of the host by the parasite...
  26. pmc Indole acetic acid distribution coincides with vascular differentiation pattern during Arabidopsis leaf ontogeny
    Orna Avsian-Kretchmer
    Department of Plant and Microbial Biology, University of California, 111 Koshland Hall, Berkeley, California 94720, USA
    Plant Physiol 130:199-209. 2002
    ..An outside IAA source for the SAM supports the notion that IAA transport and procambium differentiation dictate phyllotaxy and organogenesis...
  27. ncbi Comparative effects of auxin transport inhibitors on rhizogenesis and mycorrhizal establishment of spruce seedlings inoculated with Laccaria bicolor
    Ana Rincon
    Unité Mixte de Recherches Interactions Arbres Microorganismes, INRA Centre de Nancy, 54280 Champenoux, France
    Tree Physiol 23:785-91. 2003
    ..We conclude that fungal IAA plays an important role in plant rhizogenesis and in the establishment of ectomycorrhizal symbiosis...
  28. pmc The polar auxin transport inhibitor N-1-naphthylphthalamic acid disrupts leaf initiation, KNOX protein regulation, and formation of leaf margins in maize
    Michael J Scanlon
    Department of Plant Biology, University of Georgia, Athens, GA 30602, USA
    Plant Physiol 133:597-605. 2003
    ..A model for L1-derived margin development in maize leaves is presented...
  29. ncbi PIN proteins perform a rate-limiting function in cellular auxin efflux
    Jan Petrasek
    Institute of Experimental Botany, The Academy of Sciences of the Czech Republic, 165 02 Prague 6, Czech Republic
    Science 312:914-8. 2006
    ..This suggests a direct involvement of PINs in catalyzing cellular auxin efflux...
  30. pmc The control of storage xyloglucan mobilization in cotyledons of Hymenaea courbaril
    Henrique Pessoa dos Santos
    Seção de Fisiologia e Bioquímica de Plantas, Instituto de Botânica, CEP 01061 970, Sao Paulo, SP, Brazil
    Plant Physiol 135:287-99. 2004
    ..This is likely to increase the efficiency of carbon reserves utilization by the growing seedling in the understorey light conditions of the rain forest...
  31. pmc Interactions between auxin transport and the actin cytoskeleton in developmental polarity of Fucus distichus embryos in response to light and gravity
    Haiguo Sun
    Department of Biology, Wake Forest University, Winston Salem, North Carolina 27109 7325, USA
    Plant Physiol 135:266-78. 2004
    ..Together, these results indicate a role for auxin in the orientation of developmental polarity and suggest interactions between the actin cytoskeleton and auxin transport in F. distichus embryos...
  32. ncbi Root cap specific expression of an endo-beta-1,4-D-glucanase (cellulase): a new marker to study root development in Arabidopsis
    Elena del Campillo
    Department of Cell Biology and Molecular Genetics, University of Maryland at College Park, College Park, MD 20742, USA
    Plant Mol Biol 56:309-23. 2004
    ..We propose that AtCel5, provides a new molecular marker to further analyze the process of root cap cell separation and a root cap specific promoter for targeting to the environment genes with beneficial properties for plant growth...
  33. pmc Brassinosteroids interact with auxin to promote lateral root development in Arabidopsis
    Fang Bao
    Department of Botany and Plant Sciences and Center for Plant Cell Biology, University of California, Riverside, California 92521, USA
    Plant Physiol 134:1624-31. 2004
    ..Our observations indicate that BRs regulate auxin transport, providing a novel mechanism for hormonal interactions in plants and supporting the hypothesis that BRs promote lateral root development by increasing acropetal auxin transport...
  34. ncbi STY1 regulates auxin homeostasis and affects apical-basal patterning of the Arabidopsis gynoecium
    Joel J Sohlberg
    Department of Plant Biology and Forest Genetics, Swedish University of Agricultural Sciences, Box 7080, S 750 07 Uppsala, Sweden
    Plant J 47:112-23. 2006
    ..Our results suggest that STY1 and related genes promote normal development of the style and affect apical-basal patterning of the gynoecium through regulation of auxin homeostasis...
  35. pmc Molecular changes occurring during acquisition of abscission competence following auxin depletion in Mirabilis jalapa
    Shimon Meir
    Department of Postharvest Science of Fresh Produce, Agricultural Research Organization, The Volcani Center, Bet Dagan 50250, Israel
    Plant Physiol 141:1604-16. 2006
    ..Our results demonstrate a correlation between acquisition of competence to respond to ethylene in both leaf and stem AZs, and decline in abundance of auxin regulatory gene transcripts...
  36. ncbi Developmental stages during the rooting of in-vitro-cultured Quercus robur shoots from material of juvenile and mature origin
    N Vidal
    Instituto de Investigaciones Agrobiologicas de Galicia, CSIC, Apartado 122, 15080 Santiago de Compostela, Spain
    Tree Physiol 23:1247-54. 2003
    ..Thus, although adult oak material (C shoots) is capable of responding to the initial stimulus of auxin during the adventitious rooting process, the endogenous IAA concentration is not the factor limiting rooting in adult material...
  37. ncbi Design, synthesis, and action of oxotremorine-related hybrid-type allosteric modulators of muscarinic acetylcholine receptors
    Teresa Disingrini
    Istituto di Chimica Farmaceutica e Tossicologica, Universita degli Studi di Milano, Viale Abruzzi 42, 20131 Milano, Italy
    J Med Chem 49:366-72. 2006
    ..Thus, attaching muscarinic allosteric antagonist moieties to orthosteric muscarinic agonists may lead to hybrid compounds in which functions of both components are mixed...
  38. ncbi Arabidopsis AtGSTF2 is regulated by ethylene and auxin, and encodes a glutathione S-transferase that interacts with flavonoids
    Aaron P Smith
    Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907 1165, USA
    Plant J 36:433-42. 2003
    ..Our results indicate that AtGSTF2 is involved not only in stress responses but also in development under normal growth conditions...
  39. pmc Auxin transport synchronizes the pattern of cell division in a tobacco cell line
    Prisca Campanoni
    Biologisches Institut II, Albert Ludwigs Universitat Freiburg, Schanzlestrasse 1, D 79104 Freiburg, Germany
    Plant Physiol 133:1251-60. 2003
    ..Our findings are discussed in the context of auxin transport as synchronizing signal in cell patterning...
  40. ncbi [Graviresponse in higher plants and its regulation in molecular bases: relevance to growth and development, and auxin polar transport in etiolated pea seedlings]
    Junichi Ueda
    College of Integrated Arts and Sciences, Osaka Prefecture University, Sakai, Osaka, Japan
    Biol Sci Space 17:116-25. 2003
    ..Based on the results of expression of PsPIN2 and PsAUX1 genes under various gravistimulations, a possible role of PsPIN2 and PsAUX1 genes for auxin polar transport in etiolated pea seedlings will be discussed...
  41. ncbi Flavonoid-related regulation of auxin accumulation in Agrobacterium tumefaciens-induced plant tumors
    Katja Schwalm
    Institut fur Botanik, Technische Universitat, Schnittspahnstrasse 3, 64287 Darmstadt, Germany
    Planta 218:163-78. 2003
    ..tumefaciens-induced tumors. This, in turn, triggers vigorous proliferation and vascularization of the tumor tissues and suppresses their further differentiation...
  42. pmc Reorientation of seedlings in the earth's gravitational field induces cytosolic calcium transients
    Christoph Plieth
    Zentrum für Biochemie und Molekularbiologie, Christian Albrechts Universitat, Am Botanischen Garten 1 9 Room 517, D 24118 Kiel, Germany
    Plant Physiol 129:786-96. 2002
    ..It is concluded that [Ca(2+)](c) is part of the gravity transduction mechanism in young Arabidopsis seedlings...
  43. ncbi Arabidopsis P-glycoprotein19 participates in the inhibition of gravitropism by gravacin
    Marcela Rojas-Pierce
    Department of Botany and Plant Sciences, University of California, Riverside, Riverside, CA 92521, USA
    Chem Biol 14:1366-76. 2007
    ..Gravacin is an auxin transport inhibitor that inhibits PGPs, particularly PGP19, which can be used to further dissect the role of PGP19 without the inhibition of other auxin transporters, namely PIN proteins...
  44. pmc Genetic and chemical reductions in protein phosphatase activity alter auxin transport, gravity response, and lateral root growth
    A M Rashotte
    Department of Biology, Wake Forest University, Winston Salem, NC 27109, USA
    Plant Cell 13:1683-97. 2001
    ..These results support the role of protein phosphorylation in regulating auxin transport and suggest that the acropetal and basipetal auxin transport streams are differentially regulated...
  45. ncbi Regulation of polar auxin transport by AtPIN1 in Arabidopsis vascular tissue
    L Gälweiler
    Max Delbruck Laboratorium in der Max Planck Gesellschaft, Carl von Linne Weg 10, D 50829 Köln, Germany
    Science 282:2226-30. 1998
    ..AtPIN1 may act as a transmembrane component of the auxin efflux carrier...
  46. pmc The TIR1 protein of Arabidopsis functions in auxin response and is related to human SKP2 and yeast grr1p
    M Ruegger
    Department of Biology, Indiana University, Bloomington, Indiana 47405 USA
    Genes Dev 12:198-207. 1998
    ..Because Grr1p and other F-box proteins have been implicated in ubiquitin-mediated processes, we speculate that auxin response depends on the modification of a key regulatory protein(s) by ubiquitin or a ubiquitin-related protein...
  47. ncbi Genetic analysis of the effects of polar auxin transport inhibitors on root growth in Arabidopsis thaliana
    H Fujita
    Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Japan
    Plant Cell Physiol 37:1094-101. 1996
    ..thaliana, and (4) in contrast to NPA, TIBA itself has a weak auxin-like inhibitory effect...
  48. pmc Alteration of auxin polar transport in the Arabidopsis ifl1 mutants
    R Zhong
    Department of Botany, University of Georgia, Athens, Georgia 30602, USA
    Plant Physiol 126:549-63. 2001
    ..Taken together, these results suggest a correlation between the reduced auxin polar transport and the alteration of cell differentiation and morphology in the ifl1 mutants...
  49. pmc Role of auxin-induced reactive oxygen species in root gravitropism
    J H Joo
    Center for Cell Signaling Research, Department of Biological Sciences, Ewha Womans University, Seoul 120-750, South Korea
    Plant Physiol 126:1055-60. 2001
    ..Furthermore, the scavenging of ROS by antioxidants (N-acetylcysteine, ascorbic acid, and Trolox) inhibited root gravitropism. These results indicate that the generation of ROS plays a role in root gravitropism...
  50. pmc The Relationship between auxin transport and maize branching
    Andrea Gallavotti
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Plant Physiol 147:1913-23. 2008
    ..Based on our results, we propose a general model for branching during maize inflorescence development...
  51. pmc Expression of gibberellin 20-oxidase1 (AtGA20ox1) in Arabidopsis seedlings with altered auxin status is regulated at multiple levels
    Isabel Desgagné-Penix
    Biology Department, University of Texas at San Antonio, San Antonio, Texas 78249, USA
    J Exp Bot 59:2057-70. 2008
    ..Thus results show that, in intact auxin- and auxin transport inhibitor-treated light-grown Arabidopsis seedlings, three other levels of regulation supersede the effects of auxin on AtGA20ox1...
  52. ncbi Variation in indole-3-acetic acid transport and its relationship with growth in etiolated lupin hypocotyls
    Juana Inés López Nicolás
    Departamento de Biología Vegetal Fisiología Vegetal, Facultad de Biologia, Universidad de Murcia, Campus de Espinardo, 30100 Murcia, Spain
    J Plant Physiol 164:851-60. 2007
    ..These results suggest that a basipetally decreasing gradient in PAT along the hypocotyl, which changes with age, may be responsible for auxin distribution pattern controlling growth...
  53. ncbi Signals controlling root suckering and adventitious shoot formation in aspen (Populus tremuloides)
    Xianchong Wan
    Department of Renewable Resources, University of Alberta, Edmonton, Alberta, Canada T6G 2H1
    Tree Physiol 26:681-7. 2006
    ....
  54. ncbi Effect of auxin transport inhibitors and ethylene on the wood anatomy of poplar
    U Junghans
    Forstbotanisches Institut, Georg August Universitat Gottingen, Gottingen, Germany
    Plant Biol (Stuttg) 6:22-9. 2004
    ....
  55. ncbi Inhibited polar auxin transport results in aberrant embryo development in Norway spruce
    Emma Larsson
    Department of Plant Biology and Forest Genetics, Swedish University of Agricultural Sciences, PO Box 7080, SE 75007 Uppsala, Sweden
    New Phytol 177:356-66. 2008
    ..This suggests that the role of polar auxin transport is conserved between angiosperms and gymnosperms...
  56. ncbi The ABC subfamily B auxin transporter AtABCB19 is involved in the inhibitory effects of N-1-naphthyphthalamic acid on the phototropic and gravitropic responses of Arabidopsis hypocotyls
    Akitomo Nagashima
    Genetic Regulatory Systems Research Team, RIKEN Plant Science Center, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa, 230 0045 Japan
    Plant Cell Physiol 49:1250-5. 2008
    ..These data thus suggest that AtABCB19 plays an important role in the inhibitory effects of NPA on hypocotyl tropism induced by auxin...
  57. ncbi Parallel synthesis and biological activity of a new class of high affinity and selective delta-opioid ligand
    D R Barn
    Organon Laboratories Ltd, Newhouse, ML1 5SH, Scotland, UK
    Bioorg Med Chem 9:2609-24. 2001
    ..v.)...
  58. pmc Phthalascidin, a synthetic antitumor agent with potency and mode of action comparable to ecteinascidin 743
    E J Martinez
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 96:3496-501. 1999
    ..The relationship of chemical structure and antitumor activity for this class of molecules has been clarified by this study...
  59. pmc Small-molecule aggregates inhibit amyloid polymerization
    Brian Y Feng
    Department of Pharmaceutical Chemistry and Graduate Group in Chemistry and Chemical Biology, University of California San Francisco, 1700 4th Street, San Francisco, California 94158 2330, USA
    Nat Chem Biol 4:197-9. 2008
    ..They also blocked infection of yeast cells with Sup35 prions, which suggests that colloidal inhibition may be relevant in more biological milieus...
  60. ncbi Newer N-phthaloyl GABA derivatives with antiallodynic and antihyperalgesic activities in both sciatic nerve and spinal nerve ligation models of neuropathic pain
    Perumal Yogeeswari
    Pharmacy Group, Birla Institute of Technology and Science, Pilani, Rajasthan, India
    Pharmacology 81:21-31. 2008
    ..Hence, the present study was undertaken to assess the peripheral analgesic, antiallodynic and antihyperalgesic activities of the synthesized structural analogues of GABA...
  61. doi Aggregator compounds confound amyloid fibrillization assay
    Gilbert M Rishton
    Nat Chem Biol 4:159-60. 2008
  62. ncbi Synthesis and anti-cancer activity of benzothiazole containing phthalimide on human carcinoma cell lines
    Stanton Hon Lung Kok
    Lo Ka Chung Centre for Natural Anti cancer Drug Development Laboratory B, Hong Kong Polytechnic University, Yuk Choi Road, Hung Hom, Kowloon, Hong Kong, China
    Bioorg Med Chem 16:3626-31. 2008
    ..We further demonstrated that both caspase-dependent and -independent pathways are involved in our novel benzothiazole containing phthalimide induced apoptosis on cancer cells...
  63. ncbi Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide
    Tomonori Yanagawa
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Bioorg Med Chem Lett 16:4748-51. 2006
    ..The structure-activity relationship for fluorine substitution was elucidated...
  64. ncbi Biological evaluation of some selected cyclic imides: mitochondrial effects and in vitro cytotoxicity
    Silvia Regina Tozato Prado
    Department of Biochemistry and Molecular Biology, Federal University of Parana, Curitiba, Parana, Brazil
    Z Naturforsch C 59:663-72. 2004
    Cyclic imides such as succinimides, maleimides, glutarimides, phthalimides and their derivatives contain an imide ring and a general structure -CO-N(R)-CO- that confers hydrophobicity and neutral characteristic...
  65. ncbi Determination of fungicides in natural waters using solid-phase microextraction and gas chromatography coupled with electron-capture and mass spectrometric detection
    D A Lambropoulou
    Department of Chemistry, University of Ioannina, Greece
    J Chromatogr A 893:143-56. 2000
    ..captan, folpet and captafol--belong to different classes of chemical compound (chloroanilines, sulphamides, phthalimides and oxazolidines) and are used mainly in agriculture and as antifouling paints...
  66. ncbi Conformationally restricted analogues of remoxipride as potential antipsychotic agents
    M H Norman
    Division of Organic Chemistry, Burroughs Wellcome Co, Research Triangle Park, North Carolina 27709
    J Med Chem 36:3417-23. 1993
    ..4, FLA-797) included 2,3-dihydro-4H-1,3-benzoxazin-4-ones, 2,3-dihydro-4H-1,3-benzthiazin-4-ones, phthalimides, 1-isoindolinones, 1,2-benzisothiazol-3(2H)-ones, and 1,2-benzisothiazol-3(2H)-one 1,1-dioxides...
  67. ncbi Synthesis and antimicrobial activity of new adamantane derivatives I
    A Orzeszko
    Agricultural University, Institute of Chemistry, Warszawa, Poland
    Acta Biochim Pol 47:87-94. 2000
    ..and trimellitic anhydride chloride appeared very useful for preparation of a number of N-substituted phthalimides. Antimicrobial activity of the newly obtained derivatives such as, for example, 4-(adamant-1-ylmethoxycarbonyl)-..
  68. ncbi Ruthenium-catalyzed carbonylation at ortho C-h bonds in aromatic amides leading to phthalimides: C-h bond activation utilizing a bidentate system
    Satoshi Inoue
    Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565 0871, Japan
    J Am Chem Soc 131:6898-9. 2009
    ..The complex 9 was isolated by the stoichiometric reaction of 1b and Ru(3)(CO)(12), in which 1b binds to one Ru atom in the expected N,N fashion and the carbonyl oxygen binds to the other Ru atom as an O donor...
  69. ncbi Palladium-catalyzed double carbonylation reactions of o-dihaloarenes with amines in phosphonium salt ionic liquids
    Hong Cao
    Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario K1N 6N5, Canada
    Org Lett 12:4126-9. 2010
    ..with amines in phosphonium salt ionic liquids proceeds efficiently to give the corresponding N-substituted phthalimides. This process can tolerate a wide array of functional groups and affords products in excellent yields...
  70. ncbi Sulfoximine assisted Pd(II)-catalyzed bromination and chlorination of primary β-C(sp3)-H bond
    Raja K Rit
    School of Chemistry, University of Hyderabad, Hyderabad 500046, India
    Org Lett 16:5258-61. 2014
    ..and chlorination of the 1°-β-C(sp(3))-H bond of MPyS-N-amides is realized under the influence of N-Br/Cl-phthalimides and a Pd(II)-catalyst...
  71. ncbi Evaluation of antiproliferative effect of N-(alkyladamantyl)phthalimides in vitro
    Margareta Horvat
    Department of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenicka 54, 10000 Zagreb, Croatia
    Chem Biol Drug Des 79:497-506. 2012
    A series of (1-adamantyl)phthalimides, 1-4, and (2-adamantyl)phthalimides, 5-8, characterized by different chain length between the adamantyl and the phthalimide moiety were synthesized, as well as 1- and 2-adamantylphthalimides ..
  72. ncbi Design and synthesis of phthalimide-type histone deacetylase inhibitors
    Chihiro Shinji
    Institute of Molecular and Cellular Biosciences, The University of Tokyo Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Bioorg Med Chem Lett 15:4427-31. 2005
    ....
  73. ncbi Potential inhibitory effect of LASSBio-596, a new thalidomide hybrid, on inflammatory corneal angiogenesis in rabbits
    Joao Crispim M L Ribeiro
    Universidade Federal do Ceara, Ceara, Brazil
    Ophthalmic Res 48:177-85. 2012
    ..Evaluate the effect of LASSBio-596, structurally designed as a new hybrid of thalidomide, on inflammatory corneal angiogenesis...
  74. pmc Two-photon fluorescence spectroscopy and imaging of 4-dimethylaminonaphthalimide peptide and protein conjugates
    Alan M McLean
    Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States
    J Phys Chem B 117:15935-42. 2013
    ..Together, these studies provide strong evidence that 4-DMN is a useful probe in two-photon imaging, with advantageous properties for cellular experiments. ..
  75. pmc The rib1 mutant of Arabidopsis has alterations in indole-3-butyric acid transport, hypocotyl elongation, and root architecture
    Julie Poupart
    Department of Biology, McGill University, Montreal, Quebec, Canada
    Plant Physiol 139:1460-71. 2005
    ..Taken together, our results support a model in which endogenous IBA influences wild-type seedling morphology. Modifications in IBA distribution in seedlings affect hypocotyl and root elongation, as well as lateral root formation...
  76. ncbi Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety
    Kalyan K Sethi
    Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi 835215, India
    Bioorg Med Chem 21:5973-82. 2013
    ..The high sequence hCA alignment homology and molecular docking study of compounds was performed to rationalize the SAR reported over here. ..
  77. ncbi Synthesis of 4-aminophthalimide and 2,4-diaminopyrimidine C-nucleosides as isosteric fluorescent DNA base substitutes
    Michael Weinberger
    Department of Chemistry, Karlsruhe Institute of Technology, Fritz Haber Weg 6, Campus Sud, Geb 30 42, 76131 Karlsruhe, Germany
    J Org Chem 78:2589-99. 2013
    ..These are remarkable optical properties considering the very small size of the chromophore and indicate a high potential of these nucleoside analogues for fluorescent DNA analytics and imaging...
  78. pmc Synthesis and thermodynamic evaluation of mixed hexadentate linear iron chelators containing hydroxypyridinone and terephthalamide units
    Rebecca J Abergel
    Department of Chemistry, University of California, Berkeley, California 94720 1460, USA
    Inorg Chem 45:3622-31. 2006
    ..Moreover, the high affinity for the ferric ion of the discussed linear ligands strongly correlates with their ability to remove iron in vivo...
  79. ncbi DNA methylation in breast and colorectal cancers
    Anshu Agrawal
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA
    Mod Pathol 20:711-21. 2007
    ....
  80. ncbi Synthesis of N-alkoxyphthalimides under ultrasound irradiation
    Shu Xiang Wang
    College of Chemistry and Environmental Science, Hebei University, Key Laboratory of Analytical Science and Technology of Hebei Province, Baoding 071002, PR China
    Ultrason Sonochem 15:33-6. 2008
    ..Compared with conventional methods, the main advantages of the present procedure are milder conditions, shorter reaction time and higher yields...
  81. ncbi Aldehyde selective Wacker oxidations of phthalimide protected allylic amines: a new catalytic route to beta3-amino acids
    Barbara Weiner
    Department of Organic and Molecular Inorganic Chemistry, Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    J Am Chem Soc 131:9473-4. 2009
    ..The aldehydes are produced in excellent yields and exhibit a large substrate scope. Beta-amino acids and alcohols are synthesized by oxidation or reduction and subsequent deprotection...
  82. ncbi Synthesis and antiviral activity of phthiobuzone analogues
    Ya jun Yang
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People s Republic of China
    Chem Pharm Bull (Tokyo) 58:208-11. 2010
    ..Compounds 9c and 9d with a propylene linker between the phthalimide and bisthiosemicarbazone moieties display similar antiviral potency against herpes simplex virus 1 (IC(50)=2.85 and 4.11 microg/ml, respectively)...
  83. pmc Chemical stimulation of the Arabidopsis thaliana root using multi-laminar flow on a microfluidic chip
    Matthias Meier
    Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 E 57th Street, Chicago, IL, USA
    Lab Chip 10:2147-53. 2010
    ....
  84. ncbi Comparative expression pattern analysis of WUSCHEL-related homeobox 2 (WOX2) and WOX8/9 in developing seeds and somatic embryos of the gymnosperm Picea abies
    Joakim Palovaara
    School of Natural Sciences, Linnaeus University, SE 391 82 Kalmar, Sweden
    New Phytol 188:122-35. 2010
    ..Our results suggest an ancestral role of WOX in seed plant embryo development, and strengthen the proposed connection between PAT, PIN-FORMED (PIN) and WOX in the regulation of embryo patterning in seed plants...
  85. ncbi Decarbonylative cycloaddition of phthalimides with 1,3-dienes
    Kyohei Fujiwara
    Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615 8510, Japan
    Org Lett 12:4548-51. 2010
    The decarbonylative cycloadditions of phthalimides with 1,3-dienes were performed by using nickel catalyst. The reactions afford 3-vinyldihydroisoquinolones regioselectively with respect to both 1,3-dienes and phthalimides.
  86. ncbi Rice develop wavy seminal roots in response to light stimulus
    Shu Jen Wang
    Department of Agronomy, National Taiwan University, Taipei 106, Taiwan
    Plant Cell Rep 30:1747-58. 2011
    ..In addition, the ketol oxylipins derived from allene oxide synthase (EC 4.2.1.92)-mediated fatty acid oxygenation function as intracellular signals for triggering the light-induced wavy root phenotype...
  87. pmc Inhibition of protein kinase Cβ reverses increased blood-brain barrier permeability during hyperglycemic stroke and prevents edema formation in vivo
    Marilyn J Cipolla
    Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Stroke 42:3252-7. 2011
    ..We investigated the effect of circulating factors and protein kinase Cβ on blood-brain barrier permeability and edema during hyperglycemic stroke...
  88. ncbi Rational design of a cyclin A fluorescent peptide sensor
    Elena Pazos
    Departamento de Química Orgánica y Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares CIQUS, Unidad Asociada al CSIC, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain
    Org Biomol Chem 9:7629-32. 2011
    ....
  89. ncbi Monoamine oxidase inhibition by C4-substituted phthalonitriles
    Clarina I Manley-King
    Pharmaceutical Chemistry, School of Pharmacy, North West University, Private Bag X6001, Potchefstroom 2520, South Africa
    Bioorg Chem 40:114-24. 2012
    It was recently reported that a series of C5-substituted phthalimides are remarkably potent reversible inhibitors of recombinant human monoamine oxidase (MAO) B...
  90. ncbi [Development of highly sensitive determination of biogenic compounds by high-performance liquid chromatography with pre-column fluorescence derivatization]
    Hirofumi Inoue
    Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Japan
    Yakugaku Zasshi 126:321-6. 2006
    ..As these proposed methods are highly sensitive and reproducible and require only a small amount of biological sample, they may be useful for clinical and biochemical research...
  91. ncbi Quantification methods of folpet degradation products in plasma with HPLC-UV/DAD: application to an in vivo toxicokinetic study in rats
    Mireille Canal-Raffin
    Departement de Pharmacologie, INSERM U657, Universite Victor Segalen Bordeaux 2, 33076 Bordeaux, France
    J Chromatogr B Analyt Technol Biomed Life Sci 865:106-13. 2008
    ..Applying these methods, a plasma toxicokinetic study of folpet in rats after intratracheal administration of Folpan 80WG showed that inhalation of folpet could be a route of exposure with an important systemic absorption...
  92. ncbi Cell handling, membrane-binding properties, and membrane-penetration modeling approaches of pivampicillin and phthalimidomethylampicillin, two basic esters of ampicillin, in comparison with chloroquine and azithromycin
    Hugues Chanteux
    Unité de Pharmacologie Cellulaire et Moléculaire, Universite Catholique de Louvain, 73 70, avenue E Mounier, 73, B 1200 Brussels, Belgium
    Pharm Res 20:624-31. 2003
    ....
  93. ncbi Design, synthesis, and structure-activity relationships of phthalimide-phenylpiperazines: a novel series of potent and selective alpha(1)(a)-adrenergic receptor antagonists
    G H Kuo
    Drug Discovery Division, Analytical Development, Global Chemical and Pharmaceutical Development Division, The R W Johnson Pharmaceutical Research Institute, Raritan, New Jersey 08869, USA
    J Med Chem 43:2183-95. 2000
    ..Compound 24 was selected as the development candidate for the treatment of BPH...
  94. ncbi Resolution by polarographic techniques of the ternary mixture of captan, captafol and folpet by using PLS calibration and artificial neuronal networks
    A Guiberteau
    Department of Analytical Chemistry, Faculty of Sciences, University of Extremadura, Badajoz, Spain
    Comput Chem 25:459-73. 2001
    ..ANN has also been applied to improve the results obtained by the PLS tool when the sampled DC current is recorded or when liquid-solid extraction with C18 cartridges is performed...
  95. pmc Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule
    Barbara J Blanchard
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 101:14326-32. 2004
    ..When the Abeta1-42 peptide was coincubated with DAPH at very low micromolar concentrations, the neuronal toxicity mentioned above (Ca(2+) influx) was eliminated. Clearly, DAPH is a promising candidate for AD therapy...
  96. ncbi Hydrolysis of naptalam and structurally related amides: inhibition by dissolved metal ions and metal (hydr)oxide surfaces
    C H Huang
    Department of Geography, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Agric Food Chem 47:4425-34. 1999
    ....
  97. ncbi Sulfophthalimide as major metabolite formed from sulfonated phthalocyanine dyes by the white-rot fungus Bjerkandera adusta
    A Heinfling-Weidtmann
    Department of Microbial Ecology, Technical University of Berlin, Sekr. OE 5, Franklinstrasse 29, 10587 Berlin, Germany
    FEMS Microbiol Lett 203:179-83. 2001
    ..Quantitative assessment of the SPI formed from RB15 accounted for approximately 60% of the theoretical amount...
  98. ncbi Proteasome inhibitors suppress formation of polyglutamine-induced nuclear inclusions in cultured postmitotic neurons
    Woo Yang Kim
    Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York 14214, USA
    J Neurochem 91:1044-56. 2004
    ..These findings further implicate Hsp70 as a neuroprotective molecule and they suggest the potential utility of certain proteasome inhibitors in the treatment of polyglutamine diseases...
  99. ncbi Sorption and desorption of flumioxazin to soil, clay minerals and ion-exchange resin
    Jason A Ferrell
    Department of Agronomy, University of Florida, Gainesville, FL 32611, USA
    Pest Manag Sci 61:40-6. 2005
    ..From these data it was concluded that flumioxazin can become readily available in soil solution with increase in soil water content...
  100. ncbi High performance liquid chromatographic determination of mazindol in human plasma
    A Kaddoumi
    Department of Analytical Research for Pharmacoinformatics, Graduate School of Pharmaceutical Sciences, Nagasaki University, Japan
    Analyst 126:1963-8. 2001
    ..Mazindol was unstable in plasma samples left at rt and 4 degrees C. The method was applied to the determination of mazindol and Met in the plasma of a patient treated for obesity with mazindol...
  101. ncbi Cytotoxic and genotoxic effect of inhibitor of vulcanisation N-cyclohexylthiophthalimide in a battery of in vitro assays
    D Slamenova
    Department of Mutagenesis and Carcinogenesis, Slovak Academy of Sciences, Bratislava, Slovak Republic
    Mutat Res 446:35-48. 1999
    ....

Research Grants6

  1. REPERFUSION EFFECTS ON CEREBRAL ARTERY FUNCTION
    Marilyn Cipolla; Fiscal Year: 2003
    ..Therefore, Aim 3 will investigate the effects of two types of thrombolytic agents (tissue-type and urokinase) on cerebral artery function, including myogenic processes. ..
  2. Cerebral Arteriole Function during Hyperglycemic Stroke
    Marilyn Cipolla; Fiscal Year: 2009
    ....
  3. TRANSITION METAL CATALYZED C-C BONDING FORMING REACTION
    JAMES TAKACS; Fiscal Year: 2002
    ..Each application is designed to push the limits of the metal-mediated cyclization methodology, and as such will require targeted developmental work to be successful. ..
  4. Purification of Optically Labeled Oligonucleotides
    William Pearson; Fiscal Year: 2004
    ..Initial work will focus on oligonucleotide probe purification. ..
  5. Self-Assembled Solutions to Asymmetric Hydrogenation
    JAMES TAKACS; Fiscal Year: 2005
    ....
  6. Purification of Oligonucleotides and Nucleoside Triphosphates
    William Pearson; Fiscal Year: 2007
    ..The proposed work seeks to further develop an entirely new method for oligonucleotide purification, thus streamlining the development and production of these crucial substances. [unreadable] [unreadable] [unreadable]..