pantothenic acid

Summary

Summary: A butyryl-beta-alanine that can also be viewed as pantoic acid complexed with BETA ALANINE. It is incorporated into COENZYME A and protects cells against peroxidative damage by increasing the level of GLUTATHIONE.

Top Publications

  1. ncbi Effects of excess pantothenic acid administration on the other water-soluble vitamin metabolisms in rats
    Katsumi Shibata
    Laboratory of Food Science, Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga 522 8533, Japan
    J Nutr Sci Vitaminol (Tokyo) 51:385-91. 2005
  2. ncbi A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis
    Vasan K Sambandamurthy
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA
    Nat Med 8:1171-4. 2002
  3. ncbi Long-term treatment of Barth syndrome with pantothenic acid: a retrospective study
    Simone Rugolotto
    Pediatrics Section, Mother and Child Department, University of Verona, Verona, Italy
    Mol Genet Metab 80:408-11. 2003
  4. pmc Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections
    Anthony E Choudhry
    Microbial, Musculoskeletal and Proliferative Diseases and Bioinformatics, GlaxoSmithKline Pharmaceuticals, Collegeville Pennsylvania 19426, USA
    Antimicrob Agents Chemother 47:2051-5. 2003
  5. doi Coenzyme A biosynthesis: an antimicrobial drug target
    Christina Spry
    School of Biochemistry and Molecular Biology, The Australian National University, Canberra, Australia
    FEMS Microbiol Rev 32:56-106. 2008
  6. doi A fluorescent assay suitable for inhibitor screening and vanin tissue quantification
    Benfang H Ruan
    Inflammation and Immunology, Pfizer Biotherapeutics R and D, Cambridge, MA 02140, USA
    Anal Biochem 399:284-92. 2010
  7. pmc Deprivation of pantothenic acid elicits a movement disorder and azoospermia in a mouse model of pantothenate kinase-associated neurodegeneration
    Y M Kuo
    Department of Medicine, University of California, San Francisco, CA, USA
    J Inherit Metab Dis 30:310-7. 2007
  8. doi Development of a method for the parallel synthesis and purification of N-substituted pantothenamides, known inhibitors of coenzyme A biosynthesis and utilization
    Marianne van Wyk
    Department of Biochemistry, Stellenbosch University, Matieland 7602, South Africa
    Org Biomol Chem 6:4348-55. 2008
  9. ncbi Fermentative activity and production of volatile compounds by Saccharomyces grown in synthetic grape juice media deficient in assimilable nitrogen and/or pantothenic acid
    X D Wang
    Department of Food Science and Human Nutrition, Washington State University, Pullman, WA 99164 6376, USA
    J Appl Microbiol 94:349-59. 2003
  10. ncbi The structure of the pantothenate kinase.ADP.pantothenate ternary complex reveals the relationship between the binding sites for substrate, allosteric regulator, and antimetabolites
    Robert A Ivey
    Department of Structural Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 279:35622-9. 2004

Detail Information

Publications202 found, 100 shown here

  1. ncbi Effects of excess pantothenic acid administration on the other water-soluble vitamin metabolisms in rats
    Katsumi Shibata
    Laboratory of Food Science, Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga 522 8533, Japan
    J Nutr Sci Vitaminol (Tokyo) 51:385-91. 2005
    ..data concerning the tolerable upper intake level which prevents health problems from an excessive intake of pantothenic acid, an animal experiment was done...
  2. ncbi A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis
    Vasan K Sambandamurthy
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA
    Nat Med 8:1171-4. 2002
    ..Here we report that an auxotrophic mutant of M. tuberculosis defective in the de novo biosynthesis of pantothenic acid (vitamin B5) is highly attenuated in immunocompromised SCID mice and in immunocompetent BALB/c mice...
  3. ncbi Long-term treatment of Barth syndrome with pantothenic acid: a retrospective study
    Simone Rugolotto
    Pediatrics Section, Mother and Child Department, University of Verona, Verona, Italy
    Mol Genet Metab 80:408-11. 2003
    We report on three patients (two are brothers) with confirmed Barth syndrome treated with pantothenic acid. This treatment is still controversial and only one study has reported positive results to date...
  4. pmc Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections
    Anthony E Choudhry
    Microbial, Musculoskeletal and Proliferative Diseases and Bioinformatics, GlaxoSmithKline Pharmaceuticals, Collegeville Pennsylvania 19426, USA
    Antimicrob Agents Chemother 47:2051-5. 2003
    ..Here we report the identification of the Staphylococcus aureus coaA gene and characterization of the enzyme. We have also identified a series of low-molecular-weight compounds which are effective inhibitors of S. aureus CoaA...
  5. doi Coenzyme A biosynthesis: an antimicrobial drug target
    Christina Spry
    School of Biochemistry and Molecular Biology, The Australian National University, Canberra, Australia
    FEMS Microbiol Rev 32:56-106. 2008
    b>Pantothenic acid, a precursor of coenzyme A (CoA), is essential for the growth of pathogenic microorganisms. Since the structure of pantothenic acid was determined, many analogues of this essential metabolite have been prepared...
  6. doi A fluorescent assay suitable for inhibitor screening and vanin tissue quantification
    Benfang H Ruan
    Inflammation and Immunology, Pfizer Biotherapeutics R and D, Cambridge, MA 02140, USA
    Anal Biochem 399:284-92. 2010
    Vanin-1 is a pantetheinase that catalyzes the hydrolysis of pantetheine to produce pantothenic acid (vitamin B5) and cysteamine...
  7. pmc Deprivation of pantothenic acid elicits a movement disorder and azoospermia in a mouse model of pantothenate kinase-associated neurodegeneration
    Y M Kuo
    Department of Medicine, University of California, San Francisco, CA, USA
    J Inherit Metab Dis 30:310-7. 2007
    We asked whether a movement disorder could be elicited by deprivation of pantothenic acid (PA; vitamin B5), the substrate for the enzyme pantothenate kinase 2 (PANK2), which is deficient in the inherited neurological disorder PKAN (..
  8. doi Development of a method for the parallel synthesis and purification of N-substituted pantothenamides, known inhibitors of coenzyme A biosynthesis and utilization
    Marianne van Wyk
    Department of Biochemistry, Stellenbosch University, Matieland 7602, South Africa
    Org Biomol Chem 6:4348-55. 2008
    N-Substituted pantothenamides are a class of pantothenic acid analogues which have been shown to act as inhibitors of coenzyme A biosynthesis and utilization, especially by blocking fatty acid metabolism through formation of inactive acyl ..
  9. ncbi Fermentative activity and production of volatile compounds by Saccharomyces grown in synthetic grape juice media deficient in assimilable nitrogen and/or pantothenic acid
    X D Wang
    Department of Food Science and Human Nutrition, Washington State University, Pullman, WA 99164 6376, USA
    J Appl Microbiol 94:349-59. 2003
    To understand the impact of assimilable nitrogen and pantothenic acid on fermentation rate and synthesis of volatile compounds by Saccharomyces under fermentative conditions.
  10. ncbi The structure of the pantothenate kinase.ADP.pantothenate ternary complex reveals the relationship between the binding sites for substrate, allosteric regulator, and antimetabolites
    Robert A Ivey
    Department of Structural Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 279:35622-9. 2004
    ....
  11. ncbi Pantothenic acid and pantothenol increase biosynthesis of glutathione by boosting cell energetics
    Vyacheslav S Slyshenkov
    Nencki Institute of Experimental Biology, Pasteura 3, 02 093 Warsaw, Poland
    FEBS Lett 569:169-72. 2004
    We have previously observed (summarized in BioFactors 17 (2003) 61) that pantothenic acid, pantothenol and other derivatives that are precursors of CoA protect cells and whole organs against peroxidative damage by increasing the content ..
  12. ncbi Feedback inhibition of pantothenate kinase regulates pantothenol uptake by the malaria parasite
    Adele M Lehane
    School of Biochemistry and Molecular Biology, Medical School, The Australian National University, Canberra, ACT 0200, Australia
    J Biol Chem 282:25395-405. 2007
    ..Furosemide reduced this inherent feedback inhibition by competing with coenzyme A for binding to pantothenate kinase, thereby increasing pantothenol uptake...
  13. ncbi Pantothenate utilization by Plasmodium as a target for antimalarial chemotherapy
    C Spry
    Research School of Biology, College of Medicine, Biology and Environment, The Australian National University, Canberra, ACT, 0200, Australia
    Infect Disord Drug Targets 10:200-16. 2010
    ..The tools currently available for identifying inhibitors of pantothenate utilization that may be potent antiplasmodial agents are also discussed...
  14. pmc Geminal dialkyl derivatives of N-substituted pantothenamides: synthesis and antibacterial activity
    T Olukayode Akinnusi
    Department of Chemistry, McGill University, Montreal, Quebec, Canada
    Bioorg Med Chem 19:2696-706. 2011
    As a key precursor of coenzyme A (CoA) biosynthesis, pantothenic acid has proven to be a useful backbone to elaborate probes of this biosynthetic pathway, study CoA-utilizing systems, and design molecules with antimicrobial activity...
  15. pmc Provitamin B5 (pantothenol) inhibits growth of the intraerythrocytic malaria parasite
    Kevin J Saliba
    School of Biochemistry and Molecular Biology, Faculty of Science, The Australian National University, Canberra ACT 0200, Australia
    Antimicrob Agents Chemother 49:632-7. 2005
    b>Pantothenic acid, a precursor of the crucial enzyme cofactor coenzyme A, is one of a relatively few nutrients for which the intraerythrocytic parasite has an absolute and acute requirement from the external medium...
  16. pmc Antibacterial activity of N-pentylpantothenamide is due to inhibition of coenzyme a synthesis
    Jacob Thomas
    Departments of Microbiology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Antimicrob Agents Chemother 54:1374-7. 2010
    ..We report that AcpH readily removes the N5-Pan-modified prosthetic group both in vivo and in vitro and show that N5-Pan blocks coenzyme A synthesis...
  17. ncbi CJ-15,801, a fungal natural product, inhibits the intraerythrocytic stage of Plasmodium falciparum in vitro via an effect on pantothenic acid utilisation
    Kevin J Saliba
    School of Biochemistry and Molecular Biology, The Australian National University, Canberra, ACT 0200, Australia
    Mol Biochem Parasitol 141:129-31. 2005
  18. ncbi The antibiotic activity of N-pentylpantothenamide results from its conversion to ethyldethia-coenzyme a, a coenzyme a antimetabolite
    Erick Strauss
    Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, New York, 14853, USA
    J Biol Chem 277:48205-9. 2002
    b>Pantothenic acid (vitamin B(5)) is the natural precursor of coenzyme A (CoA), an essential cofactor in all organisms...
  19. ncbi Hypolipidemic effect of pantothenic acid derivatives in mice with hypothalamic obesity induced by aurothioglucose
    E Naruta
    Department of Experimental Hepathology, Institute of Biochemistry, National Academy of Sciences, Grodno, Belarus
    Exp Toxicol Pathol 53:393-8. 2001
    The hypolipidemic effects of pantothenic acid derivatives (phosphopantothenate, panthenol and pantethine) were studied in mice with hypothalamic obesity...
  20. ncbi Coenzyme A metabolism
    J D Robishaw
    Am J Physiol 248:E1-9. 1985
    ..Changes in the rate of coenzyme A synthesis in liver and heart occurs with fasting, refeeding, and diabetes and in heart muscle with hypertrophy. The pathway and regulation of coenzyme A degradation are not understood...
  21. ncbi Determination of pantothenic acid in foods by optical biosensor immunoassay
    Simon A Haughey
    Xenosense Ltd, Unit 18, The Innovation Centre, Northern Ireland Science Park, Queen s Rd, Queen s Island, Belfast, N Ireland, BT3 9DT
    J AOAC Int 88:1008-14. 2005
    An optical biosensor inhibition immunoassay was developed using a specific pantothenic acid-binding protein for the quantitation of free pantothenic acid (vitamin B5) in foodstuffs...
  22. pmc Stable isotope labeling by essential nutrients in cell culture for preparation of labeled coenzyme A and its thioesters
    Sankha S Basu
    Centers of Excellence in Environmental Toxicology and Cancer Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Anal Chem 83:1363-9. 2011
    ..This methodology of stable isotope labeling by essential nutrients in cell culture (SILEC) can serve as a paradigm for using vitamins and other essential nutrients to generate stable isotope standards that cannot be readily synthesized...
  23. ncbi Saccharomyces cerevisiae is capable of de Novo pantothenic acid biosynthesis involving a novel pathway of beta-alanine production from spermine
    W H White
    Department of Applied Biotechnology, DuPont Pharmaceuticals Company, Wilmington, Delaware 19880 0336, USA
    J Biol Chem 276:10794-800. 2001
    b>Pantothenic acid and beta-alanine are metabolic intermediates in coenzyme A biosynthesis...
  24. pmc A class of pantothenic acid analogs inhibits Plasmodium falciparum pantothenate kinase and represses the proliferation of malaria parasites
    Christina Spry
    School of Biochemistry and Molecular Biology, The Australian National University, Canberra ACT 0200, Australia
    Antimicrob Agents Chemother 49:4649-57. 2005
    ..One nutrient for which the parasite has an absolute requirement is the water-soluble vitamin pantothenic acid (vitamin B5)...
  25. ncbi Acyl carrier protein is a cellular target for the antibacterial action of the pantothenamide class of pantothenate antimetabolites
    Yong Mei Zhang
    Protein Science Division, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 279:50969-75. 2004
    ..Thus, the pantothenamides are pro-antibiotics that inhibit fatty acid synthesis and bacterial growth because of the covalent modification of ACP...
  26. pmc Protection elicited by a double leucine and pantothenate auxotroph of Mycobacterium tuberculosis in guinea pigs
    Samantha L Sampson
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Infect Immun 72:3031-7. 2004
    ..The deltaleuD deltapanCD double auxotroph is fully attenuated in the SCID mouse model and highly immunogenic and protective in the extremely sensitive guinea pig tuberculosis model, reducing both bacterial burden and disease pathology...
  27. ncbi Vitamin transport and homeostasis in mammalian brain: focus on Vitamins B and E
    Reynold Spector
    Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    J Neurochem 103:425-38. 2007
    ..In most cases (with the exception of the sodium-dependent multivitamin transporter for biotin, pantothenic acid, and lipoic acid), the vitamins are transported by separate carriers through the blood-brain barrier or ..
  28. ncbi Effect of thiamine hydrochloride, pyridoxine hydrochloride and calcium-d-pantothenate on the patulin content of apple juice concentrate
    Serafettin Yazici
    Nahrung 46:256-7. 2002
    ..5 to 67.7% of patulin reduction which was only 35.8% for the control while the other quality parameters were protected adequately...
  29. ncbi Vitamins, minerals and supplements: part two
    June Thompson
    Community Pract 78:366-8. 2005
    ....
  30. ncbi [Dietary survey in Hungary, 2003-2004. Micronutrients: vitamins]
    Gabor Zajkas
    Országos Elelmiszer biztonsági és Táplálkozástudományi Intézet, Budapest
    Orv Hetil 148:1593-600. 2007
    ..However the intake of vitamin B2 , C, D, together with pantothenic acid and folic acid of both men and women did not meet the criteria of the Hungarian recommendations, besides the ..
  31. pmc Vitamin and cofactor biosynthesis pathways in Plasmodium and other apicomplexan parasites
    Sylke Muller
    University of Glasgow, Glasgow Biomedical Research Centre, Division of Infection and Immunity, Wellcome Centre for Molecular Parasitology, 120 University Place, Glasgow G12 8TA, UK
    Trends Parasitol 23:112-21. 2007
    ..In this article, the procurement of vitamins B(1), B(5) and B(6) by Plasmodium and other apicomplexan parasites is discussed...
  32. ncbi Values of water-soluble vitamins in blood and urine of Japanese young men and women consuming a semi-purified diet based on the Japanese Dietary Reference Intakes
    Katsumi Shibata
    School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga 522 8533, Japan
    J Nutr Sci Vitaminol (Tokyo) 51:319-28. 2005
    ..total vitamin B2 in whole blood, total cyanocobalamin in serum, total nicotinamide in whole blood, total pantothenic acid in whole blood, total folates in serum, total biotin in serum, and ascorbic acid in plasma were 104+/-17 pmol/..
  33. ncbi Effects of high-level dietary B-vitamins on performance, body composition and tissue vitamin contents of growing/finishing pigs
    B M Böhmer
    Division of Animal Nutrition, TU Munich, Freising Weihenstephan, Germany
    J Anim Physiol Anim Nutr (Berl) 91:6-10. 2007
    ..The experimental groups were supplemented with 400% or 800% of vitamins B(2), B(6) and pantothenic acid, or 400% or 800% of biotin, while all other vitamins were administered according to requirement...
  34. ncbi Dietary B vitamin needs of strains of pigs with high and moderate lean growth
    T S Stahly
    Department of Animal Science, Iowa State University, Ames 50011, USA
    J Anim Sci 85:188-95. 2007
    ..were utilized to determine the impact of the dietary concentration of 5 B vitamins (riboflavin, niacin, pantothenic acid, cobalamin, and folacin) on growth from 9 to 28 kg of BW in pigs with high or moderate capacity for lean ..
  35. ncbi Delaying the mitochondrial decay of aging
    Bruce N Ames
    University of California, Berkeley, and Children s Hospital Oakland Research Institute, USA
    Ann N Y Acad Sci 1019:406-11. 2004
    ..Mitochondria provide energy for basic metabolic processes, and their decay with age impairs cellular metabolism and leads to cellular decline. Progress over the last decade in delaying the mitochondrial decay of aging is reviewed...
  36. ncbi Coenzyme A biosynthesis: reconstruction of the pathway in archaea and an evolutionary scenario based on comparative genomics
    Ulrich Genschel
    Lehrstuhl fur Genetik, Wissenschaftszentrum Weihenstephan, Technische Universitat, Munchen, Freising, Germany
    Mol Biol Evol 21:1242-51. 2004
    ..The results support the notion that CoA was initially synthesized from a prebiotic precursor, most likely pantothenate or a related compound...
  37. ncbi Mitochondrial decay, a major cause of aging, can be delayed
    Bruce N Ames
    University of California, Berkeley, CA, USA
    J Alzheimers Dis 6:117-21. 2004
    ..Our progress over the last decade in delaying the mitochondrial decay of aging is briefly reviewed...
  38. ncbi Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism
    Flore Depeint
    Department of Pharmaceutical Sciences, University of Toronto, Canada Department of Nutritional Sciences, University of Toronto, Canada
    Chem Biol Interact 163:94-112. 2006
    ..b>Pantothenic acid (B5) is required for coenzyme A formation and is also essential for alpha-ketoglutarate and pyruvate ..
  39. ncbi Mechanistic studies on phosphopantothenoylcysteine decarboxylase
    E Strauss
    J Am Chem Soc 123:6449-50. 2001
  40. ncbi Vitamin requirements of the cultured flesh fly cells, Sarcophaga peregrina (Diptera, Sarcophagidae)
    J Mitsuhashi
    Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan
    Arch Insect Biochem Physiol 46:73-7. 2001
    ..Originally published in Volume 37, Archives of Insect Biochemistry and Physiology, 37:283-286 (1998).]..
  41. pmc Genetic and biochemical analyses of pantothenate biosynthesis in Escherichia coli and Salmonella typhimurium
    J E Cronan
    J Bacteriol 149:916-22. 1982
    ..Supplementation with pantoate or ketopantoate resulted in smaller increases...
  42. pmc Elevated levels of ketopantoate hydroxymethyltransferase (PanB) lead to a physiologically significant coenzyme A elevation in Salmonella enterica serovar Typhimurium
    Aileen Rubio
    Department of Bacteriology, University of Wisconsin Madison, 1550 Linden Drive, Madison, WI 53706, USA
    J Bacteriol 184:2827-32. 2002
    ..Furthermore, overexpression of PanB caused by this mutation, or by other means, was necessary and sufficient to increase pantothenate production and allow PurF-independent thiamine synthesis on glucose medium...
  43. ncbi Molecular characterization of lantibiotic-synthesizing enzyme EpiD reveals a function for bacterial Dfp proteins in coenzyme A biosynthesis
    T Kupke
    Lehrstuhl für Mikrobielle Genetik, Universitat Tubingen, Auf der Morgenstelle 15, Verfügungsgebäude, 72076 Tubingen, Germany
    J Biol Chem 275:31838-46. 2000
    ..We demonstrate that the N-terminal domain of the Escherichia coli Dfp protein catalyzes the decarboxylation of (R)-4'-phospho-N-pantothenoylcysteine to 4'-phosphopantetheine. This reaction is essential for coenzyme A biosynthesis...
  44. ncbi Phosphopantothenoylcysteine synthetase from Escherichia coli. Identification and characterization of the last unidentified coenzyme A biosynthetic enzyme in bacteria
    E Strauss
    Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, New York, 14853, USA
    J Biol Chem 276:13513-6. 2001
    ..This discovery completes the identification of all the enzymes involved in the biosynthesis of coenzyme A in bacteria...
  45. ncbi The Aspergillus nidulans panB gene encodes ketopantoate hydroxymethyltransferase, required for biosynthesis of pantothenate and Coenzyme A
    D Kurtov
    Department of Microbiology, Monash University, Clayton, Victoria, Australia
    Mol Gen Genet 262:115-20. 1999
    ..The panB transcript is present in low abundance and, most probably, a small increase in transcript levels occurs in the absence of exogenous pantothenate...
  46. pmc Isolation and characterization of temperature-sensitive pantothenate kinase (coaA) mutants of Escherichia coli
    D S Vallari
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38101
    J Bacteriol 169:5795-800. 1987
    ..These data define the coaA gene as the structural gene for pantothenate kinase...
  47. ncbi Acyl carrier protein. X. Acyl carrier protein synthetase
    J Elovson
    J Biol Chem 243:3603-11. 1968
  48. ncbi Arabidopsis thaliana flavoprotein AtHAL3a catalyzes the decarboxylation of 4'-Phosphopantothenoylcysteine to 4'-phosphopantetheine, a key step in coenzyme A biosynthesis
    T Kupke
    , , Auf der Morgenstelle 15, , , Germany
    J Biol Chem 276:19190-6. 2001
    ..Based on the crystal structures of EpiD H67N with bound substrate peptide and of AtHAL3a, we present a model for the binding of (R)-4'-phospho-N-pantothenoylcysteine to AtHAL3a...
  49. ncbi How pantothenol intervenes in Coenzyme-A biosynthesis of Mycobacterium tuberculosis
    Parimal Kumar
    Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India
    Biochem Biophys Res Commun 361:903-9. 2007
    ..Thus, it is the failure of CoaBC to utilize 4'-phosphopantothenol as a substrate that accounts for the bactericidal activity of pantothenol...
  50. pmc Role of feedback regulation of pantothenate kinase (CoaA) in control of coenzyme A levels in Escherichia coli
    Charles O Rock
    Protein Science Division, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Bacteriol 185:3410-5. 2003
    ..These data illustrate the key role of feedback regulation of pantothenate kinase in the control of intracellular CoA levels...
  51. pmc Isolation and characterization of Escherichia coli pantothenate permease (panF) mutants
    D S Vallari
    J Bacteriol 164:136-42. 1985
    ..Two- and three-factor crosses located panF at minute 72 of the E. coli chromosome and established the gene order fabE panF aroE...
  52. ncbi The biosynthesis of coenzyme A in bacteria
    T P Begley
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York, USA
    Vitam Horm 61:157-71. 2001
    ..These intermediates are then condensed to give pantothenic acid. Phosphorylation of pantothenic acid followed by condensation with cysteine and decarboxylation gives 4'-..
  53. pmc Pantothenate transport in Escherichia coli
    D S Vallari
    J Bacteriol 162:1156-61. 1985
    The transport system for pantothenic acid uptake in Escherichia coli was characterized. This transport system was specific for pantothenate, had a Kt of 0.4 microM, and had a maximum velocity of 1...
  54. ncbi A mutant of Escherichia coli conditionally defective in the synthesis of holo-[acyl carrier protein]
    M L Polacco
    J Biol Chem 256:5750-4. 1981
    ..The site of the genetic lesion (called acpS) was localized on the E. coli genetic map...
  55. ncbi Systemic lupus erythematosus: a combined deficiency disease
    Lit Hung Leung
    Department of General Surgery, Hong Kong Central Hospital, Hong Kong
    Med Hypotheses 62:922-4. 2004
    ..lupus erythematosus (DILE) is linked to a deficiency in Coenzyme A (CoA) that is secondary to a deficiency in pantothenic acid. This hypothesis is used to explain the high incidence of SLE in females, the role of sex hormones in this ..
  56. ncbi HPLC determination of calcium pantothenate and two preservatives in topical cream
    L Havlíková
    Department of Analytical Chemistry, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic
    J Pharm Biomed Anal 41:671-5. 2006
    ..UV detection was accomplished at 214 nm. The method was validated according to ICH guideline recommendations. The method is suitable for practical routine analysis of commercially produced topical pharmaceutical preparations...
  57. ncbi Chemo- and regioselective peptide cyclization triggered by the N-terminal fatty acid chain length: the recombinant cyclase of the calcium-dependent antibiotic from Streptomyces coelicolor
    Jan Grünewald
    Fachbereich Chemie Biochemie, Philipps Universitat Marburg, Hans Meerwein Strasse, D 35032 Marburg, Germany
    Biochemistry 43:2915-25. 2004
    ....
  58. ncbi Committee on food nutrition. Water-soluble vitamins
    Erik J M Konings
    Inspectorate for Health Protection and Veterinary Public Health, PO Box 2280, 5202 CG s Hertogenbosch, The Netherlands
    J AOAC Int 86:147-9. 2003
  59. ncbi The optimization of HPLC-UV conditions for use with FTIR detection in the analysis of B vitamins
    Ying Li
    Department of Chemistry, University of Rhode Island, Kingston, RI, 02881, USA
    J Chromatogr Sci 41:96-9. 2003
    The water-soluble vitamins thiamine (B(1)), riboflavin (B(2)), pantothenic acid (B(5)), and pyridoxine (B(6)) are separated by high-performance liquid chromatography...
  60. ncbi Characterization of a new pantothenate kinase isoform from Helicobacter pylori
    Leisl A Brand
    Department of Chemistry, Stellenbosch University, Matieland 7602, South Africa
    J Biol Chem 280:20185-8. 2005
    ..They also do not accept the pantothenic acid antimetabolite N-pentylpantothenamide as a substrate or are inhibited by it...
  61. ncbi Pantothenic acid quantification: method comparison of a stable isotope dilution assay and a microbiological assay
    Michael Rychlik
    Lehrstuhl fur Lebensmittelchemie der Technischen Universitat Munchen, Lichtenbergstr 4, D 85748 Garching, Germany
    Int J Vitam Nutr Res 75:218-23. 2005
    Different foods and feedstuffs were analyzed for pantothenic acid (PA) by the recently developed stable isotope dilution assay (SIDA) and by the standard method, a microbiological assay (MA)...
  62. pmc Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis
    Yong Mei Zhang
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Chem Biol 14:291-302. 2007
    ..These results identify the metabolic rearrangements that maintain the CoASH pool which is critical to mitochondrial functions, including gluconeogenesis, fatty acid oxidation, and the tricarboxylic acid and urea cycles...
  63. pmc D-Pantothenate synthesis in Corynebacterium glutamicum and use of panBC and genes encoding L-valine synthesis for D-pantothenate overproduction
    H Sahm
    Institut fur Biotechnologie, Forschungszentrum Julich GmbH, 52425 Julich, Germany
    Appl Environ Microbiol 65:1973-9. 1999
    ....
  64. ncbi [Pantothenic acid]
    Kazuto Yasuda
    Department of Clinical Chemistry, Kagawa Nutrition University
    Nihon Rinsho 62:198-202. 2004
  65. pmc Structure of the type III pantothenate kinase from Bacillus anthracis at 2.0 A resolution: implications for coenzyme A-dependent redox biology
    Nathan I Nicely
    Center for Structural Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Biochemistry 46:3234-45. 2007
    ..Our analyses also suggest that the type III PanK in the spore-forming B. anthracis plays an essential role in the novel thiol/disulfide redox biology of this category A biodefense pathogen...
  66. ncbi Coenzyme A: back in action
    Roberta Leonardi
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
    Prog Lipid Res 44:125-53. 2005
    ..CoA is assembled in five steps from pantothenic acid and pathway intermediates are common to both prokaryotes and eukaryotes...
  67. ncbi One-pot chemo-enzymatic synthesis of reporter-modified proteins
    Andrew S Worthington
    Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0358, USA
    Org Biomol Chem 4:44-6. 2006
    ..We also probe substrate specificity for CoAA, the first enzyme in the pathway. With this approach CoA analogs may be rapidly prepared, thus permitting the regiospecific attachment of reporter moieties from a variety of molecular species...
  68. ncbi Pantothenic acid: an organ-specific pro-oxidant vitamin. Brain and liver neuroprostane levels in rats fed a pantothenic acid-deficient diet
    Jihan Youssef
    Division of Pharmacology, University of Missouri Kansas City, Kansas City, MO 64108, USA
    Adv Exp Med Biol 507:551-5. 2002
  69. ncbi Intravenous nutrient therapy: the "Myers' cocktail"
    Alan R Gaby
    Altern Med Rev 7:389-403. 2002
    ..This paper presents a rationale for the therapeutic use of intravenous nutrients, reviews the relevant published clinical research, describes the author's clinical experiences, and discusses potential side effects and precautions...
  70. ncbi Micronutrient intake during pregnancy in relation to birth size
    Pagona Lagiou
    Dept of Hygiene and Epidemiology, School of Medicine, University of Athens, Athens, Greece
    Eur J Nutr 44:52-9. 2005
    ..There exists very little information on possible effects on birth size of micronutrient intakes at levels that are usually encountered among pregnant women in developed countries...
  71. ncbi Folic acid and pantothenic acid protection against valproic acid-induced neural tube defects in CD-1 mice
    Jennifer E Dawson
    Department of Pharmacology and Toxicology and School of Environmental Studies, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Toxicol Appl Pharmacol 211:124-32. 2006
    ..We also evaluated the protective effects of folic acid and pantothenic acid on VPA-induced NTDs and VPA-induced embryonic protein changes in this model...
  72. ncbi Xenobiotics in vitro: the influence of L-cystine, pantothenat, and miliacin on metabolic and proliferative capacity of keratinocytes
    D Hoeller Obrigkeit
    Department of Dermatology and Allergology, University Clinic RWTH, Aachen, Germany
    Cutan Ocul Toxicol 25:13-22. 2006
    ..g., Priorin). Furthermore, this work emphasizes the suitability of keratinocyte monolayers for pharmacological testings...
  73. ncbi [Can dexpanthenol prevent peritoneal adhesion formation? An experimental study]
    Yusuf Akdeniz
    Department of General Surgery, Medicine Faculty of Süleyman Demirel University, Isparta, Turkey
    Ulus Travma Acil Cerrahi Derg 13:94-100. 2007
    ..Local application of dexpanthenol, the alcohol form of pantothenic acid (vitamin B5) accelerates wound healing by increasing mitosis...
  74. ncbi Effects of pantothenic acid on growth performance and carcass characteristics of growing-finishing pigs fed diets with or without ractopamine hydrochloride
    C N Groesbeck
    Department of Animal Sciences and Industry, Kansas State University, Manhattan 66506 0201, USA
    J Anim Sci 85:2492-7. 2007
    Two experiments evaluated effects of added pantothenic acid on performance of growing-finishing pigs. In Exp. 1, 156 pigs (PIC, initial BW = 25...
  75. ncbi Roles of vitamins B5, B8, B9, B12 and molybdenum cofactor at cellular and organismal levels
    Fabrice Rebeille
    Laboratoire de Physiologie Cellulaire Végétale, UMR5168, Université Joseph Fourier CNRS CEA INRA, Institut de Recherche en Technologies et Sciences du Vivant, CEA Grenoble, Grenoble, Cedex 9, France
    Nat Prod Rep 24:949-62. 2007
    ..In the second part we will present some nutritional aspects and potential strategies to enhance the cofactor contents in organisms of interest...
  76. ncbi [Can dexpanthenol prevent peritoneal adhesion formation? An experimental study]
    Emre Ergul
    Ulus Travma Acil Cerrahi Derg 13:330; author reply 331. 2007
  77. doi Simultaneous determination of some water-soluble vitamins and preservatives in multivitamin syrup by validated stability-indicating high-performance liquid chromatography method
    Stojanka Vidović
    Galenika a d, Batajnicki drum bb, 11070 Belgrade, Serbia
    J Chromatogr A 1202:155-62. 2008
    ..Typical validation characteristics: selectivity, accuracy, precision, linearity, range, limit of quantification and limit of detection were evaluated for vitamins and preservatives...
  78. ncbi Water-soluble vitamins
    Erik J M Konings
    Food and Consumer Product Safety Authority VWA, Veldmaarschalk Montgomerylaan 500, 5623 LE Eindhoven, The Netherlands
    J AOAC Int 89:285-8. 2006
    ..Pakin et al. proposed a post-column derivatization of pantothenic acid as a fluorescent compound and used this principle in a specific and sensitive method for the determination of ..
  79. ncbi An evaluation of protein assays for quantitative determination of drugs
    Katherine M Williams
    Analytical Biochemistry Group, Sunderland Pharmacy School, School of Health, Natural and Social Sciences, Fleming Building, The University of Sunderland SR1 3RG, Sunderland, UK
    J Biochem Biophys Methods 57:45-55. 2003
    ..prochlorperazine, promazine and thioridazine) and water-soluble vitamins (ascorbic acid, niacinamide, pantothenic acid and pyridoxine). The biuret, Lowry and BCA assays responded strongly to most of the drugs tested...
  80. ncbi Pharmacotherapy for dyslipidaemia--current therapies and future agents
    Harold Bays
    L MARC Research Center, 3288 Illinois Avenue, Louisville, KY 40213, USA
    Expert Opin Pharmacother 4:1901-38. 2003
    ..protein (MTP) inhibitors, acylcoenzyme A: cholesterol acyltransferase (ACAT) inhibitors, gemcabene, lifibrol, pantothenic acid analogues, nicotinic acid-receptor agonists, anti-inflammatory agents (such as Lp-PLA(2) antagonists and ..
  81. ncbi Nutritional intakes in community-dwelling older Japanese adults: high intakes of energy and protein based on high consumption of fish, vegetables and fruits provide sufficient micronutrients
    Reiko Watanabe
    Course of Food and Nutrition, Department of Human Life Environments, Niigata Women s College, Niigata 950 8680, Japan
    J Nutr Sci Vitaminol (Tokyo) 50:184-95. 2004
    ..were found between total protein intake and intakes of vitamins D, B2 and B6, as well as niacin and pantothenic acid (p<0.0001)...
  82. ncbi Tetanus toxin production in soy-based medium: nutritional studies and scale-up into small fermentors
    A L Demain
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
    Lett Appl Microbiol 45:635-8. 2007
    ..To further improve the soy-based medium, devoid of animal and dairy products, for a production of tetanus toxin by nutritional studies and to scale-up the Clostridium tetani process into small fermentors...
  83. ncbi Pickles, pectin, and penicillin
    Arnold L Demain
    Charles A Dana Research Institute for Scientists Emeriti R I S E, Drew University, Madison, New Jersey 07940, USA
    Annu Rev Microbiol 58:1-42. 2004
    ..primary metabolites (glutamic acid, tryptophan, inosinic acid, guanylic acid, vitamin B(12), riboflavin, pantothenic acid, ethanol, and lactic acid) and secondary metabolites (penicillin, cephalosporins, streptomycin, fosfomycin, ..
  84. ncbi LC/UV/MS-MRM for the simultaneous determination of water-soluble vitamins in multi-vitamin dietary supplements
    Pei Chen
    United States Department of Agricultural Research Service, Beltsville Human Nutrition Research Center, Food Composition Laboratory, Beltsville, MD, 20705, USA
    Anal Bioanal Chem 387:2441-8. 2007
    ..vitamins [thiamine (B(1)), riboflavin (B(2)), nicotinamide (B(3)), pyridoxine (B(6)) pyridoxine, biotin, pantothenic acid, and folic acid] in multi-vitamin/multi-mineral daily supplements is described...
  85. ncbi Effects of vitamin-B complex supplementation on periodontal wound healing
    Rodrigo F Neiva
    Department of Periodontics Prevention Geriatrics, School of Dentistry, University of Michigan, 1011 N University Avenue, Ann Arbor, MI 48109 1078, USA
    J Periodontol 76:1084-91. 2005
    ..Reports have demonstrated that nutrient supplements, in particular vitamin-B complex (Vit-B), can positively influence wound healing processes. However, limited information is available on the effects of Vit-B on periodontal wound healing...
  86. ncbi Vitamin intakes from supplements and fortified food in German children and adolescents: results from the DONALD study
    Wolfgang Sichert-Hellert
    Research Institute of Child Nutrition FKE, Dortmund and Rheinische Friedrich Wilhelms Universität, Bonn, Germany
    J Nutr 136:1329-33. 2006
    ..In the case of folate and pantothenic acid, intake from supplements was necessary to achieve at least 80% of recommended dietary allowances for half of ..
  87. pmc In vitro infection of Cryptosporidium parvum to four different cell lines
    J R Yu
    Department of Parasitology, College of Medicine, Konkuk University, Chungju, Korea
    Korean J Parasitol 38:59-64. 2000
    ..3-fold higher when compared to the control media. In this study, we found that the AGS cell line was a suitable host model for evaluating C. parvum in vitro study and the media contents for the optimal infection conditions were suggested...
  88. doi Vitamin-regulated cytokines and growth factors in the CNS and elsewhere
    Giuseppe Scalabrino
    Laboratory of Neuropathology, Città Studi Department, Faculty of Medicine and Surgery, University of Milan, Milan, Italy
    J Neurochem 111:1309-26. 2009
    There is a growing awareness that natural vitamins (with the only exception of pantothenic acid) positively or negatively modulate the synthesis of some cytokines and growth factors in the CNS, and various mammalian cells and organs...
  89. pmc Functional characterization of sodium-dependent multivitamin transporter in MDCK-MDR1 cells and its utilization as a target for drug delivery
    Shuanghui Luo
    Division of Pharmaceutical Science, School of Pharmacy, University of Missouri Kansas City, 5005 Rockhill Road, Kansas City, Missouri 64110 2499, USA
    Mol Pharm 3:329-39. 2006
    ..e., desthiolbiotin and valeric acid, and other vitamins such as lipoic acid and pantothenic acid, but not by acetic acid, benzoic acid, biotin methyl ester, and biocytin...
  90. ncbi [Distigmine bromide improves chronic intestinal pseudo-obstruction in a case of MELAS]
    Yoshiharu Nakae
    Department of Neurology, Yokohama City University, School of Medicine
    Rinsho Shinkeigaku 47:177-9. 2007
    ..of domperidone, mosapride citrate, butyric acid bacteria, sodium picosulfate, prostaglandin F2 alpha, pantothenic acid, dioctyl sodium sulfosuccinate, and so on, was ineffective, the administration of distigmine bromide improved ..
  91. ncbi Calf survival from embryo transfer-induced twinning in dairy-beef cows and the effects of synchronised calving
    T W Knight
    AgResearch Grasslands Research Center, Tennent Drive, Private Bag 11008, Palmerston North, New Zealand
    Anim Reprod Sci 68:1-12. 2001
    ..Hormonal synchronisation of calving can halve the time required for continuous supervision of calving, but the hormone treatments exacerbate the already high incidence of retained placenta in TC...
  92. pmc Vanin-1(-/-) mice show decreased NSAID- and Schistosoma-induced intestinal inflammation associated with higher glutathione stores
    Florent Martin
    Centre d immunologie de Marseille Luminy, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale, Universté de la Méditerranée, Marseille, France
    J Clin Invest 113:591-7. 2004
    ..It hydrolyzes pantetheine to pantothenic acid (vitamin B5) and the low-molecular-weight thiol cysteamine...
  93. ncbi Post-translational disulfide modifications in cell signaling--role of inter-protein, intra-protein, S-glutathionyl, and S-cysteaminyl disulfide modifications in signal transmission
    CATHERINE A O'BRIAN
    U T M D Anderson Cancer Center, Houston, TX, USA
    Free Radic Res 39:471-80. 2005
    ..Cystamine is a byproduct of pantetheinase-catalyzed pantothenic acid recycling from pantetheine for biosynthesis of Coenzyme A (CoA), a ubiquitous and metabolically indispensable ..
  94. doi Formulation and stability of a novel artificial human sweat under conditions of storage and use
    Christopher J Harvey
    National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Toxicol In Vitro 24:1790-6. 2010
    ..Seven indicator constituents were tracked: sodium, chloride, glucose, lactic acid, urea, pantothenic acid, and alanine. With or without sebum at 36 degrees C, the sweat solvent was chemically stable for 14 days...
  95. doi Effects of folic acid supplementation to rations differing in the concentrate to roughage ratio on ruminal fermentation, nutrient flow at the duodenum, and on serum and milk variables of dairy cows
    Veronika Ragaller
    Institute of Animal Nutrition, Friedrich Loeffler Institute FLI, Federal Research Institute of Animal Health, Braunschweig, Germany
    Arch Anim Nutr 64:484-503. 2010
    ..urea, thiamine, riboflavin, pyridoxal-5'-phosphate, pyridoxic acid, pyridoxal, pyridoxine, pyridoxamine, pantothenic acid, nicotinamide or nicotinic acid, whereas supplementing FOL to the HC diet lowered the serum glucose and ..
  96. pmc Are WHO/UNAIDS/UNICEF-recommended replacement milks for infants of HIV-infected mothers appropriate in the South African context?
    P C Papathakis
    Africa Centre for Health and Population Studies, Mtubatuba, KwaZulu Natal, South Africa
    Bull World Health Organ 82:164-71. 2004
    ....
  97. ncbi Low intake of calcium, folate, nicotinic acid, vitamin E, retinol, beta-carotene and high intake of pantothenic acid, biotin and riboflavin are significantly associated with increased genome instability--results from a dietary intake and micronucleus inde
    Michael Fenech
    CSIRO Health Sciences and Nutrition, Adelaide, Australia, Women s and Children s Hospital, Adelaide, Australia
    Carcinogenesis 26:991-9. 2005
    ..005) relative to the lowest tertile of intake and (2) the highest tertile of intake of riboflavin, pantothenic acid and biotin was associated with significant increases in MN frequency, i.e. +36% (P = 0.054), +51% (P = 0...
  98. pmc Cell and molecular aspects of human intestinal biotin absorption
    Hamid M Said
    University of California School of Medicine, Irvine, California 92697, USA
    J Nutr 139:158-62. 2009
    ..and large intestine involves a saturable and Na(+)-dependent carrier-mediated process that is shared with pantothenic acid and lipoate...
  99. ncbi Separation of water-soluble vitamins by reversed-phase high performance liquid chromatography with ultra-violet detection: application to polyvitaminated premixes
    Olivier Heudi
    Quality and Safety Department, Nestle Research Center, Nestec Ltd, Vers chez les Blanc, 1000 Lausanne 26, Switzerland
    J Chromatogr A 1070:49-56. 2005
    ..The simplicity of the procedure should make it highly desirable for quality control of premixes in the food industry...
  100. pmc Vanin-1-/- mice exhibit a glutathione-mediated tissue resistance to oxidative stress
    C Berruyer
    Centre d Immunologie de Marseille Luminy CNRS INSERM Université de la Méditerranée, 13288 Marseille, France
    Mol Cell Biol 24:7214-24. 2004
    ..ectoenzyme with pantetheinase activity and generating the amino-thiol cysteamine through the metabolism of pantothenic acid (vitamin B(5))...
  101. doi Simultaneous determination of water-soluble vitamins in SRM 1849 Infant/Adult Nutritional Formula powder by liquid chromatography-isotope dilution mass spectrometry
    Robert J Goldschmidt
    Food Composition Methods Development Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, United States Department of Agriculture, Beltsville, MD 20705, USA
    Anal Bioanal Chem 397:471-81. 2010
    ..methods for the simultaneous determination of water-soluble vitamins (thiamine, niacin, pyridoxine, pantothenic acid, folic acid, biotin, and riboflavin) in dietary supplement tablets and fortified foods, such as formula ..

Research Grants59

  1. PLACENTAL VITAMIN TRANSPORT-MOLECULAR & CELLULAR ASPECTS
    Puttur Prasad; Fiscal Year: 2003
    ..Proposed studies will also investigate the regulation of SVCT2 expression in rat placenta and BeWo cells in response to substrate availability and ontogenic development of SVCT2 in rat placenta. ..
  2. DO HIGH DOSE B VITAMINS DELAY AGE-RELATED DECAY
    Bruce Ames; Fiscal Year: 2005
    ....
  3. Tuning-Up Human Metabolism
    Bruce Ames; Fiscal Year: 2005
    ..Previous results showed that high doses of key mitochondrial metabolites delay mitochondrial decay and involve Km. 4) Minimizing DNA damage and cancer by optimizing micronutrient levels, particularly in the elderly. ..
  4. QUANTITATIVE METALLOPROTEOMICS: THE HUMAN ERYTHROCYTE
    Bruce Ames; Fiscal Year: 2006
    ..abstract_text> ..
  5. Mitochondrial Nutrients Protect RPE from Oxidant Damage
    Bruce Ames; Fiscal Year: 2006
    ..This in vitro analysis of mitochondrial nutrients may provide the basis for the development of therapeutic agents that can prevent and/or reduce the retinal and RPE pathophysiology observed in AMD. ..
  6. Metalloproteome of the Aging Rat Brain Mitochondria
    Bruce Ames; Fiscal Year: 2007
    ..Thus, this work has significant potential to integrate numerous aspects of mitochondrial metabolism and physiology and reveal novel opportunities for combating aging-related decline. ..
  7. Mechanisms of Pancreatic Thiamin Uptake:Effect of Alcohol
    Hamid M Said; Fiscal Year: 2010
    ....
  8. Human Intestinal Biotin Uptake: Molecular/Cell Mechanisms
    HAMID SAID; Fiscal Year: 2009
    ..This should ultimately assist us in the design of effective strategies to optimize biotin body homeostasis in conditions associated with biotin deficiency and sub-optimal levels. ..
  9. Mechanisms of Pancreatic Thiamin Uptake:Effect of Alcohol
    HAMID SAID; Fiscal Year: 2009
    ....
  10. Intestinal Biotin Absorption: Physiological, Cellular and Molecular Aspects
    Hamid M Said; Fiscal Year: 2010
    ..Results of these investigations should help in the designing of effective strategies to optimize biotin body levels, especially in conditions associated with biotin deficiency and sub-optimal levels. 1 ..
  11. C elegans:a model to study intestinal water-soluble vitamins transport in vivo
    HAMID SAID; Fiscal Year: 2007
    ..This should be of great value in future investigations into the mechanisms and regulation of transport of water-soluble vitamins in the intestine (and other tissues) at the integrated whole animal level in vivo. ..
  12. Mechanism/regulation of human intestinal thiamin uptake
    HAMID SAID; Fiscal Year: 2007
    ..This should ultimately assist us in the designing of effective strategies to optimize thiamin body homeostasis in conditions associated with thiamin deficiency and sub-optimal levels. ..
  13. Human Intestinal Biotin Uptake:Molecular /Cell Mechanisms
    HAMID SAID; Fiscal Year: 2007
    ..This should ultimately assist us in the design of effective strategies to optimize biotin body homeostasis in conditions associated with biotin deficiency and sub-optimal levels. ..
  14. Mitochondrial Metabiolites to Treat Parkinson's Disease
    Bruce Ames; Fiscal Year: 2005
    ..This project on PD is a new direction for our work on preventing mitochondrial decay and could lead to an effective and cost efficient prevention /therapy for PD. ..
  15. INTESTINAL VITAMIN H UPTAKE--MOLECULAR/CELL REGULATION
    HAMID SAID; Fiscal Year: 2004
    ..has been recently shown to be also utilized by two other functionally unrelated nutrients, namely the vitamin pantothenic acid and the metabolically important antioxidant lipoate [for this reason the system involved is also being ..
  16. DELAYING MITOCHONDRIAL DECAY WITH CARNITINE AND LIPOATE
    Bruce Ames; Fiscal Year: 2001
    ..abstract_text> ..
  17. MALDI-TOF MASS SPECTROMETER
    Bruce Ames; Fiscal Year: 2002
    ..abstract_text> ..
  18. NATURAL VITAMIN E FORMS AS ANTI-INFLAMMATORY DRUGS
    Bruce Ames; Fiscal Year: 2003
    ..abstract_text> ..
  19. CHARACTERIZATION OF INTESTINAL ABSORPTION OF VITAMIN B1
    HAMID SAID; Fiscal Year: 2003
    ..abstract_text> ..
  20. UCLA Pharmacogenetics and Pharmacogenomics Research Grp*
    Julio Licinio; Fiscal Year: 2005
    ..Our data will be deposited in PharmacoGKB, GenBank, and dbSNP. Additionally, our clinical responses data and DNA samples will be deposited in the UCLA DNA Bank that is accessible to other investigators. ..
  21. ENDOCRINE EFFECTS OF HUMAN LEPTIN REPLACEMENT
    Julio Licinio; Fiscal Year: 2005
    ..Discontinuation of this study would be highly deleterious, not only for the patients, but also for our understanding of the long-term effects of leptin in humans. ..
  22. Probing Microb Comm - Stable Isotope & RNA/DNA Analyses
    James Tiedje; Fiscal Year: 2004
    ..abstract_text> ..
  23. PKC Cys switches -- novel cancer prevention targets
    CATHERINE O BRIAN; Fiscal Year: 2006
    ....
  24. Developing Educational Approaches for Mexican-Americans
    Julio Licinio; Fiscal Year: 2005
    ..Their input will also be incorporated into the article that will be submitted to a peer-reviewed journal. ..
  25. UCLA GRADUATE TRAINING PROGRAM IN TRANSITIONAL INVESTIGA
    Julio Licinio; Fiscal Year: 2004
    ..abstract_text> ..
  26. Clinical Neuroendocrinology of Leptin
    Julio Licinio; Fiscal Year: 2006
    ..This work may reveal new sites of leptin action with potential therapeutic value. ..