Genomes and Genes
Summary: Compounds with a core of 10 carbons generally formed via the mevalonate pathway from the combination of 3,3-dimethylallyl pyrophosphate and isopentenyl pyrophosphate. They are cyclized and oxidized in a variety of ways. Due to the low molecular weight many of them exist in the form of essential oils (OILS, VOLATILE).
Publications243 found, 100 shown here
- Monoterpene and sesquiterpene synthases and the origin of terpene skeletal diversity in plantsJörg Degenhardt
Martin Luther University Halle Wittenberg, Institute for Pharmacy, Halle Saale, Germany
Phytochemistry 70:1621-37. 2009....
- Mechanisms of antibacterial action of three monoterpenesDomenico Trombetta
Department Farmaco Biologico, School of Pharmacy, University of Messina, Contrada Annunziata, 98168 Messina, Italy
Antimicrob Agents Chemother 49:2474-8. 2005In the present paper, we report the antimicrobial efficacy of three monoterpenes [linalyl acetate, (+)menthol, and thymol] against the gram-positive bacterium Staphylococcus aureus and the gram-negative bacterium Escherichia coli...
- Complex interactions among host pines and fungi vectored by an invasive bark beetleMin Lu
State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
New Phytol 187:859-66. 2010..valens and their pine hosts in China may confer advantages to these strains of L. procerum and, by extension, to the beetles themselves. These interactions may therefore enhance invasion by the beetle-fungal complex...
- The phenolic hydroxyl group of carvacrol is essential for action against the food-borne pathogen Bacillus cereusA Ultee
Wageningen Centre for Food Sciences, Department of Preservation Technology and Food Safety, Agrotechnological Research Institute ATO B V, Wageningen, The Netherlands
Appl Environ Microbiol 68:1561-8. 2002..The resulting collapse of the proton motive force and depletion of the ATP pool eventually lead to cell death...
- Mechanisms of action of carvacrol on the food-borne pathogen Bacillus cereusA Ultee
Agrotechnological Research Institute, 6700 AA Wageningen, The Netherlands
Appl Environ Microbiol 65:4606-10. 1999..cereus by changing its permeability for cations like H(+) and K(+). The dissipation of ion gradients leads to impairment of essential processes in the cell and finally to cell death...
- (-)-Linalool produces antinociception in two experimental models of painAlessandra T Peana
Dipartimento di Scienze del Farmaco, Universita degli Studi di Sassari, Via Muroni 23 A, 07100 Sassari, Italy
Eur J Pharmacol 460:37-41. 2003..Finally, the activation of opioidergic and cholinergic systems appears to play a crucial role in (-)-linalool-induced antinociception...
- Monoterpenoids induce agonist-specific desensitization of transient receptor potential vanilloid-3 (TRPV3) ion channelsMuhammad Azhar Sherkheli
Department of Cell Physiology, Ruhr University Bochum, Bochum 44801, Germany
J Pharm Pharm Sci 12:116-28. 2009..In the present investigation TRPV3 was transiently expressed in either Xenopus oocytes or HEK293 cells. Whole-cell voltage-clamp techniques were used to characterize the behavior of TRPV3 when challenged with different agonists...
- Identification of genes and proteins necessary for catabolism of acyclic terpenes and leucine/isovalerate in Pseudomonas aeruginosaKarin Förster-Fromme
Institut fur Mikrobiologie, Universitat Stuttgart, Allmandring 31, 70550 Stuttgart, Germany
Appl Environ Microbiol 72:4819-28. 2006..A regulatory gene, atuR, was identified upstream of atuABCDEFGH and negatively regulated expression of the atu gene cluster...
- Comparative study on the antiviral activity of selected monoterpenes derived from essential oilsAkram Astani
Department of Virology, Hygiene Institute, University of Heidelberg, Heidelberg, Germany
Phytother Res 24:673-9. 2010..These essential oils were able to reduce viral infectivity by >96%, the monoterpenes inhibited HSV by about >80%...
- Anti-proliferative effects of carvacrol on a human metastatic breast cancer cell line, MDA-MB 231K M Arunasree
Institute of Life Sciences, University of Hyderabad Campus, Biology, Hyderabad 500 046, AP, India
Phytomedicine 17:581-8. 2010....
- Inhibition of membrane bound ATPases of Escherichia coli and Listeria monocytogenes by plant oil aromaticsA O Gill
Department of Food Science, Faculty of Agriculture and Food Sciences, 250 Ellis Building, 13 Freedman Crescent, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
Int J Food Microbiol 111:170-4. 2006..The percent partitioning of E. coli was significantly greater than both other organisms (23.3%) and may explain the greater sensitivity of E. coli to all three aromatics...
- The influence of Ceratocystis polonica inoculation and methyl jasmonate application on terpene chemistry of Norway spruce, Picea abiesTao Zhao
Ecological Chemistry Group, Department of Chemistry, Royal Institute of Technology, SE 100 44 Stockholm, Sweden
Phytochemistry 71:1332-41. 2010..Thus, terpene composition in the stem bark may be related to resistance of Norway spruce against I. typographus and C. polonica...
- Biosynthesis of mono- and sesquiterpenes in carrot roots and leaves (Daucus carota L.): metabolic cross talk of cytosolic mevalonate and plastidial methylerythritol phosphate pathwaysDaniela Hampel
Institut fur Lebensmittelchemie, Johann Wolfgang Goethe Universitat, Marie Curie Strasse 9, D 60439 Frankfurt Main, Germany
Phytochemistry 66:305-11. 2005The biosynthesis of the monoterpenes terpinolene and myrcene and the sesquiterpene beta-caryophyllene in roots and leaves of two carrot varieties (Daucus carota L...
- Monoterpenoid biosynthesis in Saccharomyces cerevisiaeMarilyne Oswald
UMR Santé de la Vigne et Qualité du Vin, Universite Louis Pasteur Strasbourg, Institut National de la Recherche Agronomique, Colmar, France
FEMS Yeast Res 7:413-21. 2007..We also showed that geraniol synthase expression affects the general ergosterol pathway, but in a manner dependent on the genetic background of the strain...
- Plant terpenes affect intensity and temporal parameters of pheromone detection in a mothVirginie Party
Unité Mixte de Recherche 1272 Physiologie de l Insecte, Signalisation et Communication, Institut National de Recherche Agronomique, Universite Pierre et Marie Curie, Route de Saint Cyr, 78000 Versailles Cedex, France
Chem Senses 34:763-74. 2009..Ph-ORN responses of Spodoptera littoralis to the main pheromone component, Z9E11-14:Ac, in the presence of 4 monoterpenes. To mimic natural contexts in which plant odors and pheromone emanate from different sources, the 2 stimuli ..
- Bioassay-guided evaluation of antioxidant and antinociceptive activities of carvacrolAdriana G Guimarães
Department of Physiology, Federal University of Sergipe DFS UFS, Sao Cristovao, SE, Brazil
Basic Clin Pharmacol Toxicol 107:949-57. 2010..Together, these results indicate that the properties of CARV should be more thoroughly examined in order to achieve newer tools for management and/or treatment of painful conditions, including those related to pro-oxidant states...
- A novel heat-shock protein coinducer boosts stress protein Hsp70 to activate T cell regulation of inflammation in autoimmune arthritisLotte Wieten
Institute of Infectious Diseases and Immunology, Utrecht University, 3584 CL Utrecht, The Netherlands
Arthritis Rheum 62:1026-35. 2010..This study was undertaken to test the hypothesis that boosting of endogenous HSP expression can restore effective immunoregulation through T cells specific for stress proteins...
- Defensive function of herbivore-induced plant volatile emissions in natureA Kessler
Department of Molecular Ecology, Max-Planck-Institute for Chemical Ecology, Jena 07745, Germany
Science 291:2141-4. 2001..As a consequence, a plant could reduce the number of herbivores by more than 90% by releasing volatiles. These results confirm that indirect defenses can operate in nature...
- Formation of monoterpenes in Antirrhinum majus and Clarkia breweri flowers involves heterodimeric geranyl diphosphate synthasesDorothea Tholl
Max Planck Institute for Chemical Ecology, D 007745 Jena, Germany
Plant Cell 16:977-92. 2004The precursor of all monoterpenes is the C10 acyclic intermediate geranyl diphosphate (GPP), which is formed from the C5 compounds isopentenyl diphosphate and dimethylallyl diphosphate by GPP synthase (GPPS)...
- Proton-transfer-reaction mass spectrometry as a new tool for real time analysis of root-secreted volatile organic compounds in ArabidopsisMarco Steeghs
Aeronomy Laboratory, National Oceanic and Atmospheric Administration, Boulder, Colorado 80305, USA
Plant Physiol 135:47-58. 2004..The PTR-MS method may open the way for functional root VOC analysis that will complement genomic investigations in Arabidopsis...
- Inhibitory activity of 1,8-cineol (eucalyptol) on cytokine production in cultured human lymphocytes and monocytesUwe R Juergens
Department of Pneumology, Allergology and Sleep Medicine, Medical Outpatient Clinic, Bonn University Hospital, Wilhelmestrasse 35 37, Bonn D 53111, Germany
Pulm Pharmacol Ther 17:281-7. 2004....
- Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channelsMoshe Parnas
Department of Physiology, Kühne Minerva Center for Studies of Visual Transduction, Faculty of Medicine, The Hebrew University, Jerusalem 91120, Israel
Cell Calcium 45:300-9. 2009..Our finding that the activity of the non-thermoTRPs, TRPL and TRPM7 channels is modulated by the same compound as thermoTRPs, suggests that common mechanisms of channel modulation characterize TRP channels...
- Bactericidal action of binary and ternary mixtures of carvacrol, thymol, and eugenol against Listeria innocuaRebeca García-García
Dept de Ingeniería Química, Alimentos y Ambiental, Univ de las Américas Puebla, Cholula, Puebla 72820, Mexico
J Food Sci 76:M95-100. 2011..25, and 56.25 mg kg(-1), correspondingly, was the most effective for L. innocua inactivation. Several binary and ternary mixtures of these 3 natural antimicrobial agents worked adequately to inactivate L. innocua...
- Effect of water stress and fungal inoculation on monoterpene emission from an historical and a new pine host of the mountain pine beetleInka Lusebrink
Department of Biological Sciences, University of Alberta, CW405 Biological Science Building, Edmonton, Alberta, T6G 2E9, Canada
J Chem Ecol 37:1013-26. 2011..into the experiment, water deficit seedlings of both species released significantly lower levels of total monoterpenes than well watered seedlings. Needle tissue contained lower total monoterpene content than bark...
- Antileukemia activity of perillyl alcohol (POH): uncoupling apoptosis from G0/G1 arrest suggests that the primary effect of POH on Bcr/Abl-transformed cells is to induce growth arrestS S Clark
Department of Human Oncology, Oncology and the UW Comprehensive Cancer Center, University of Wisconsin, Madison, WI, USA
Leukemia 16:213-22. 2002....
- Carvacrol prevents diet-induced obesity by modulating gene expressions involved in adipogenesis and inflammation in mice fed with high-fat dietSoomin Cho
Department of Food and Nutrition, Brain Korea 21 Project, Yonsei University, Seoul 120 749, Korea
J Nutr Biochem 23:192-201. 2012....
- Carvacrol, a component of thyme oil, activates PPARalpha and gamma and suppresses COX-2 expressionMariko Hotta
Department of Food Science and Nutrition, Nara Women s University Nara 630 8506 Japan
J Lipid Res 51:132-9. 2010..These results may be important in understanding the antiinflammatory and antilifestyle-related disease properties of carvacrol...
- Catabolism of citronellol and related acyclic terpenoids in pseudomonadsKarin Förster-Fromme
Institut fur Mikrobiologie, Universitat Stuttgart, Allmandring 31, 70550, Stuttgart, Germany
Appl Microbiol Biotechnol 87:859-69. 2010..This minireview summarises knowledge on catabolic pathways and biotransformations of acyclic monoterpenes that have received only little attention...
- Two nearly identical terpene synthases catalyze the formation of nerolidol and linalool in snapdragon flowersDinesh A Nagegowda
Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907, USA
Plant J 55:224-39. 2008Terpenoids emitted from snapdragon flowers include three monoterpenes derived from geranyl diphosphate (GPP), myrcene, (E)-beta-ocimene and linalool, and a sesquiterpene, nerolidol, derived from farnesyl diphosphate (FPP)...
- Changes in membrane fatty acids composition of microbial cells induced by addiction of thymol, carvacrol, limonene, cinnamaldehyde, and eugenol in the growing mediaRosangela Di Pasqua
Department of Food Science, Division of Microbiology, University of Naples Federico II, Via Universita 100, 80055 Portici, Italy
J Agric Food Chem 54:2745-9. 2006..All compounds influenced the fatty acid profile of B. thermosphacta, while Pseudomonas and S. aureus strains did not show substantial changes in their fatty acid compositions...
- Influence of carvacrol on growth and toxin production by Bacillus cereusA Ultee
Agrotechnological Research Institute ATO DLO, Wageningen, The Netherlands Wageningen Centre for Food Sciences, Wageningen, The Netherlands
Int J Food Microbiol 64:373-8. 2001..From this study it can be concluded that carvacrol can be added to food products at doses below the MIC value, thereby reducing the risk of toxin production by B. cereus and increasing the safety of the products...
- Mechanisms of carvacrol-induced expression of type I collagen geneJongsung Lee
Biospectrum Life Science Institute, 101 701 SK Ventium, 522 Dangjung Dong, Gunpo City, 435 833 Gyunggi Do, Republic of Korea
J Dermatol Sci 52:160-9. 2008..Skin aging is accompanied by wrinkle formation and appears to be principally related to decreases in the levels of type I collagen, the primary component of the dermal layer of skin...
- Antifumonisin activity of natural phenolic compounds A structure-property-activity relationship studyJosé S Dambolena
Instituto Multidisciplinario de Biología Vegetal CONICET, Catedra de Quimica Organica, FCEFyN UNC, Avenida Vélez Sarsfield 1611, X5016GCA Córdoba Argentina
Int J Food Microbiol 145:140-6. 2011..These findings could provide an important contribution in the search for new compounds with antifumonisin activity...
- Quinones and halogenated monoterpenes of algal origin show anti-proliferative effects against breast cancer cells in vitroJo Anne de la Mare
The Biomedical Biotechnology Research Unit BioBRU, Department of Biochemistry, Microbiology and Biotechnology, Rhodes University, P O Box 94, Grahamstown, 6140, South Africa
Invest New Drugs 30:2187-200. 2012..In addition, cell cycle analyses revealed that the compound causes G(1) arrest in MDA-MB-231 cells...
- Volatile components of peel and leaf oils of lemon and lime speciesMarie Laure Lota
Université de Corse, Equipe Chimie et Biomasse, UMR CNRS 6134, Route des Sanguinaires, 20000 Ajaccio, France
J Agric Food Chem 50:796-805. 2002..Four others were identified for lime leaf oils: beta-pinene/limonene; limonene/geranial/neral; limonene/linalool/citronellal; and limonene/sabinene/citronellal/linalool. These results were interpreted using principal component analysis...
- Fumigant and contact toxicities of monoterpenes to Sitophilus oryzae (L.) and Tribolium castaneum (Herbst) and their inhibitory effects on acetylcholinesterase activitySamir A M Abdelgaleil
Department of Pesticides Chemistry, Faculty of Agriculture, Alexandria University, 21545 El Shatby, Alexandria, Egypt
J Chem Ecol 35:518-25. 2009A comparative study was conducted to assess the contact and fumigant toxicities of eleven monoterpenes on two important stored products insects--, Sitophilus oryzae, the rice weevil, and Tribolium castaneum, the rust red flour beetle...
- Antidepressant-like effect of carvacrol (5-Isopropyl-2-methylphenol) in mice: involvement of dopaminergic systemFrancisca Helvira Cavalcante Melo
Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Rua Cel Nunes de Melo, Fortaleza, Brazil
Fundam Clin Pharmacol 25:362-7. 2011..Keywords: Carvacrol; Antidepressant; Forced swimming; Tail suspension; Dopaminergic system...
- Interaction of four monoterpenes contained in essential oils with model membranes: implications for their antibacterial activityMariateresa Cristani
Department Farmaco Biologico, School of Pharmacy, University of Messina, Contrada Annunziata, 98168 Messina, Italy
J Agric Food Chem 55:6300-8. 2007The present article reports the antimicrobial efficacy of four monoterpenes (thymol, carvacrol, p-cymene, and gamma-terpinene) against the Gram-positive bacterium Staphylococcus aureus and the Gram-negative bacterium Escherichia coli...
- The 1-deoxy-D: -xylulose 5-phosphate synthase gene co-localizes with a major QTL affecting monoterpene content in grapevineJuri Battilana
Department of Genetics and Molecular Biology, IASMA Research Center, Fondazione Edmund Mach, 38010 San Michele all Adige, Italy
Theor Appl Genet 118:653-69. 2009..From a chemical point of view, it is strongly related to the accumulation of monoterpenes in berries. However, knowledge of the genetic mechanisms underlying its regulation is still limited...
- Anxiolytic-like effect of Carvacrol (5-isopropyl-2-methylphenol) in mice: involvement with GABAergic transmissionFrancisca Helvira Cavalcante Melo
Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Rua Cel Nunes de Melo 1127, 60430 270 Fortaleza, Brazil
Fundam Clin Pharmacol 24:437-43. 2010..These results show that CVC presents anxiolytic effects in the plus maze test which are not influenced by the locomotor activity in the open-field test...
- Coriander spice oil: effects of fruit crushing and distillation time on yield and compositionB M Smallfield
New Zealand Institute for Crop and Food Research Ltd, Invermay Agriculture Centre, Mosgiel, New Zealand
J Agric Food Chem 49:118-23. 2001..Crushing had little effect on linalool content, but distillation time could be manipulated to alter the linalool content of the oil...
- Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomesMitsuo Miyazawa
Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University, Kowakae, Higashiosaka, Osaka, Japan
Drug Metab Dispos 30:602-7. 2002..Species-related differences exist in the oxidations of limonenes in CYP2B subfamily in rats and humans...
- A candidate gene association study on muscat flavor in grapevine (Vitis vinifera L.)Francesco Emanuelli
Research and Innovation Center, Fondazione Edmund Mach Istituto Agrario di San Michele all Adige, Via E, Mach 1, 38010 San Michele all Adige TN, Italy
BMC Plant Biol 10:241. 2010..has up to now been studied by evaluating monoterpenoid levels through QTL analysis. These studies have revealed co-localization of 1-deoxy-D-xylulose 5-phosphate synthase (VvDXS) with the major QTL positioned on chromosome 5...
- An integrated genomic, proteomic and biochemical analysis of (+)-3-carene biosynthesis in Sitka spruce (Picea sitchensis) genotypes that are resistant or susceptible to white pine weevilDawn E Hall
Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada
Plant J 65:936-48. 2011..In conclusion, variation of the (+)-3-carene phenotype is controlled by copy number variation of PsTPS-3car genes, variation of gene and protein expression, and variation in catalytic efficiencies...
- Enhanced levels of the aroma and flavor compound S-linalool by metabolic engineering of the terpenoid pathway in tomato fruitsE Lewinsohn
Newe Ya ar Research Center, Agricultural Research Organization, Ramat Yishay 30095, Israel
Plant Physiol 127:1256-65. 2001..Our studies indicate that it is possible to enhance the levels of monoterpenes in ripening fruits by metabolic engineering.
- Chemistry and biology of monoterpene indole alkaloid biosynthesisSARAH E O'CONNOR
Department of Chemistry, Massachusetts Institute of Technology, Building 18 592, Cambridge, MA 02139 4307, USA
Nat Prod Rep 23:532-47. 2006
- Real-time monitoring of herbivore induced volatile emissions in the fieldAndrea Schaub
Ionicon Analytik GmbH, Technikerstrasse 21a, 6020 Innsbruck, Austria
Physiol Plant 138:123-33. 2010..However, there was a clear effect on SQT measurements. Elucidation of emission patterns in real-time is dependent upon the dynamics of cuvettes at different temperatures...
- Differential timing of spider mite-induced direct and indirect defenses in tomato plantsMerijn R Kant
Institute for Biodiversity and Ecosystem Dynamics, Department of Plant Physiology, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
Plant Physiol 135:483-95. 2004..Although transcriptional up-regulation of the enzymes involved in the biosynthesis of monoterpenes and diterpenes already occurred on day one, a significant increase in the emission of volatile terpenoids was ..
- cDNA isolation, functional expression, and characterization of (+)-alpha-pinene synthase and (-)-alpha-pinene synthase from loblolly pine (Pinus taeda): stereocontrol in pinene biosynthesisMichael A Phillips
Institute of Biological Chemistry, Washington State University, Pullman, WA 99164 6340, USA
Arch Biochem Biophys 411:267-76. 2003The complex mixture of monoterpenes, sesquiterpenes, and diterpenes that comprises oleoresin provides the primary defense of conifers against bark beetles and their associated fungal pathogens...
- Optimization of the transient transformation of Catharanthus roseus cells by particle bombardment and its application to the subcellular localization of hydroxymethylbutenyl 4-diphosphate synthase and geraniol 10-hydroxylaseGrégory Guirimand
Universite Francois Rabelais de Tours, EA 2106 Biomolécules et Biotechnologies Végétales, IFR 135 Imagerie Fonctionnelle, 37200, Tours, France
Plant Cell Rep 28:1215-34. 2009..Furthermore, we also demonstrated that G10H is an ER-anchored protein, consistent with the presence of a transmembrane helix at the G10H N-terminal end, which is both necessary and sufficient to drive the ER anchoring...
- Screening of chemical composition and antifungal and antioxidant activities of the essential oils from three Turkish artemisia speciesSaban Kordali
Department of Plant Protection, Faculty of Agriculture, Kazim Karabekir Education Faculty, Ataturk University, 25240 Erzurum, Turkey
J Agric Food Chem 53:1408-16. 2005..All of the studied essential oils showed antioxidant activity, but camphor and 1,8-cineole did not...
- Hsp70 expression and induction as a readout for detection of immune modulatory components in foodLotte Wieten
Department of Infectious Diseases and Immunology, Utrecht University, The Netherlands
Cell Stress Chaperones 15:25-37. 2010..These assay systems are generally applicable to identify compounds that affect the Hsp level in cells of the immune system...
- Fungicidal activity of thymol and carvacrol by disrupting ergosterol biosynthesis and membrane integrity against CandidaA Ahmad
Department of Biosciences, Jamia Millia Islamia, New Delhi, India
Eur J Clin Microbiol Infect Dis 30:41-50. 2011..The mechanisms of action of these natural isopropyl cresols appear to originate from the inhibition of ergosterol biosynthesis and the disruption of membrane integrity...
- Spatial distribution and hormonal regulation of gene products from methyl erythritol phosphate and monoterpene-secoiridoid pathways in Catharanthus roseusAudrey Oudin
EA 2106 Biomolécules et Biotechnologies Végétales, UFR des Sciences Pharmaceutiques, Universite Francois Rabelais de Tours, Tours, France
Plant Mol Biol 65:13-30. 2007..roseus cells, our results support that intercellular translocation likely plays an important role during monoterpene-secoiridoid assembly...
- Disruption of Escherichia coli, Listeria monocytogenes and Lactobacillus sakei cellular membranes by plant oil aromaticsA O Gill
Department of Food Science, Faculty of Agriculture and Food Sciences, 250 Ellis Building, 13 Freedman Crescent, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
Int J Food Microbiol 108:1-9. 2006..Secondary effects would also be consistent with membrane disruption...
- Carvacrol induces heat shock protein 60 and inhibits synthesis of flagellin in Escherichia coli O157:H7Sara A Burt
Institute for Risk Assessment Sciences, Division of Veterinary Public Health, Faculty of Veterinary Medicine, Utrecht University, 3508TD Utrecht, The Netherlands
Appl Environ Microbiol 73:4484-90. 2007..This study is the first to demonstrate that essential oil components induce HSP60 in bacteria and that overnight incubation with carvacrol prevents the development of flagella in E. coli O157:H7...
- Effects of oregano, carvacrol and thymol on Staphylococcus aureus and Staphylococcus epidermidis biofilmsAntonia Nostro
Dipartimento Farmaco Biologico, Facolta di Farmacia, Universita degli Studi di Messina, Villaggio Annunziata, 98168 Messina, Italy
J Med Microbiol 56:519-23. 2007..Subinhibitory concentrations of the oils attenuated biofilm formation of S. aureus and S. epidermidis strains on polystyrene microtitre plates...
- Identification and quantification of aerosol polar oxygenated compounds bearing carboxylic or hydroxyl groups. 2. Organic tracer compounds from monoterpenesM Jaoui
Alion Science and Technology, P O Box 12313, Research Triangle Park, North Carolina 27709, USA
Environ Sci Technol 39:5661-73. 2005..NC, during the summer of 2003, and the laboratory samples originated from the photooxidation of the following monoterpenes: alpha-pinene, beta-pinene, and d-limonene...
- Monoterpenes as novel substrates for oxidation and halo-hydroxylation with chloroperoxidase from Caldariomyces fumagoBjoern Arne Kaup
Biochemical Engineering Group, DECHEMA e V, Karl Winnacker Institut, Theodor Heuss Allee 25, 60486, Frankfurt, Germany
Appl Microbiol Biotechnol 73:1087-96. 2007Chloroperoxidase (CPO) from Caldariomyces fumago was analysed for its ability to oxidize ten different monoterpenes with hydrogen peroxide as oxidant...
- Plant-derived compounds inactivate antibiotic-resistant Campylobacter jejuni strainsSadhana Ravishankar
Department of Veterinary Science and Microbiology, University of Arizona, 1117 East Lowell Street, Tucson, Arizona 85721, USA
J Food Prot 71:1145-9. 2008..jejuni strains, at concentrations of approximately 0.1% and higher. The antimicrobial efficacy of cinnamaldehyde was greater than that of carvacrol. The possible significance of the results for microbiological food safety is discussed...
- In vitro acaricidal activity of four monoterpenes and solvents against Otodectes cynotis (Acari: Psoroptidae)Oliver Traina
Clinique Vétérinaire du Boulou, Le Boulou, France
Exp Appl Acarol 37:141-6. 2005
- In vitro acetylcholinesterase inhibitory properties of thymol, carvacrol and their derivatives thymoquinone and thymohydroquinoneMila Jukic
Faculty of Chemistry and Technology, Department of Biochemistry, University of Split, Teslina 10 V, 21000 Split, Croatia
Phytother Res 21:259-61. 2007..It is interesting that the AChE inhibitory effect exerted by carvacrol was 10 times stronger than that exerted by its isomer thymol, although thymol and carvacrol have a very similar structure...
- De novo synthesis of monoterpenes by Saccharomyces cerevisiae wine yeastsFrancisco M Carrau
Seccion Enologia, Departmento de Ciencia y Tecnologia de Alimentos, Facultad de Quimica, Universidad de la Republica, 11800 Montevideo, Uruguay
FEMS Microbiol Lett 243:107-15. 2005This paper reports the production of monoterpenes, which elicit a floral aroma in wine, by strains of the yeast Saccharomyces cerevisiae...
- The atu and liu clusters are involved in the catabolic pathways for acyclic monoterpenes and leucine in Pseudomonas aeruginosaJ A Aguilar
Instituto de Investigaciones Quimico Biologicas, Universidad Michoacana de San Nicolas de Hidalgo, Edif B 3, Ciudad Universitaria, CP 58030, Morelia, Michoacan, Mexico
Appl Environ Microbiol 72:2070-9. 2006..utilization) homolog cluster was found in the PAO1 genome and is related to the catabolism of acyclic monoterpenes of the citronellol family (AMTC); it was named the atu cluster (acyclic terpene utilization), consisting of the ..
- Acetylcholinesterase and butyrylcholinesterase inhibition of ethanolic extract and monoterpenes from Pimpinella anisoides V Brig. (Apiaceae)Federica Menichini
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, Italy
Fitoterapia 80:297-300. 2009..7 and 209.6 microg/ml, respectively. The bicyclic monoterpene (+)-sabinene exhibited a promising activity against AChE (IC(50) of 176.5 microg/ml) and BChE (IC(50) of 218.6 microg/ml)...
- Purification and identification of carvacrol from the root of Stellera chamaejasme and research on its insecticidal activityXiaorong Tang
College of Physics and Chemistry, Xihua University, Chengdu 610039, PR China
Nat Prod Res 25:320-5. 2011..Its median lethal concentrations (LC(50)) (24 h after treatment) were 16.8 and 12.7 mg L(-1), respectively. This is the first report of the insecticidal activity of carvacrol against A. craccivora and L. separata...
- Modulation of genotoxicity and DNA repair by plant monoterpenes camphor, eucalyptol and thujone in Escherichia coli and mammalian cellsBiljana Nikolic
University of Belgrade, Faculty of Biology, Chair of Microbiology, Studentski trg 3 II, 11000 Belgrade, Serbia
Food Chem Toxicol 49:2035-45. 2011The aim of this work was to examine the antigenotoxic potential of plant monoterpenes: camphor, eucalyptol and thujone in prokaryotic and eukaryotic cells and to elucidate their effect on DNA repair...
- Variation in complex semiochemical signals arising from insects and host plantsBrian H Aukema
Canadian Forest Service, Natural Resources Canada, Prince George, BC, Canada
Environ Entomol 39:874-82. 2010..Phloem from white pine had the greatest concentration of monoterpenes, although insects tunneling in white pine produced the smallest ratios of monoterpenes to pheromones (1:2) in ..
- Physical and chemical responses of Sitka spruce (Picea sitchensis) clones to colonization by Heterobasidion annosum as potential markers for relative host susceptibilitySteve Woodward
University of Aberdeen, School of Biological Sciences, Department of Plant and Soil Science, Cruickshank Building, St Machar Drive, Aberdeen AB24 3UU, U K
Tree Physiol 27:1701-10. 2007..The concentrations of the monoterpenes, except a few minor constituents, increased in the infected tissues. Wounding plus inoculation with H...
- Genetic variation for sensitivity to a thyme monoterpene in associated plant speciesCatrine Grønberg Jensen
Department of Biological Sciences, University of Aarhus, Ny Munkegade, Build 1540, 8000 Arhus C, Denmark
Oecologia 162:1017-25. 2010..The different responses within a species suggest that plant-plant interactions can evolve; this has implications for community dynamics and stability...
- Effect of monoterpenes on lipid oxidation in maizeMaría P Zunino
Instituto Multidisciplinario de Biología Vegetal, Catedra de Quimica Organica, Facultad de Ciencias Exactas Fisicas y Naturales, Universidad Nacional de Cordoba, Av Vélez Sarsfield 1600, 5016 Cordoba, Argentina
Planta 219:303-9. 2004The monoterpenes 1,8-cineole, thymol, geraniol, menthol and camphor strongly inhibited the root growth of Zea mays L. seedlings...
- DNA methyl transferase inhibiting halogenated monoterpenes from the Madagascar red marine alga Portieria hornemanniiEric H Andrianasolo
College of Pharmacy, Oregon State University, Corvallis, OR 97331, USA
J Nat Prod 69:576-9. 2006Three new halogenated monoterpenes, 2, 3, and 4, along with the known compounds halomon (1) and two analogues, 5 and 6, were isolated from the Madagascar red marine alga Portieria hornemannii...
- Electrophysiological and behavioral responses of Dendroctonus valens (Coleoptera: Curculionidae: Scolytinae) to four bark beetle pheromonesLongwa Zhang
State Key Laboratory of Integrated Management Agricultural Pest and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
Environ Entomol 38:472-7. 2009..The possible roles of the pheromones in host and mate finding and selection are discussed...
- Microtubules are an intracellular target of the plant terpene citralDavid Chaimovitsh
Division of Aromatic Plants, Agricultural Research Organization, Newe Ya ar, PO Box 1021, Ramat Yishai 30095, Israel
Plant J 61:399-408. 2010..In addition, polymerization of microtubules in vitro was inhibited in the presence of citral. Taken together, our results suggest that citral is a potent, volatile, anti-microtubule compound...
- Glycosidic monoterpenes from Linaria caprariaArmandodoriano Bianco
Dipartimento di Chimica Università La Sapienza e Istituto di Chimica Biomolecolare del CNR, Piazzale Aldo Moro 5, 00185, Roma, Italy
Nat Prod Res 18:241-6. 2004..In addition a glucoside of an acyclic monoterpene, 4, was also isolated, which may be correlated to the other monoterpenic glycosides isolated from other species of Scrophulariaceae...
- Demonstration that menthofuran synthase of mint (Mentha) is a cytochrome P450 monooxygenase: cloning, functional expression, and characterization of the responsible geneC M Bertea
Department of Plant Biology, University of Turin, Viale P.A. Mattioli 25, I-10125Turin, Italy
Arch Biochem Biophys 390:279-86. 2001..The availability of this gene permits transgenic manipulation of peppermint to improve the quality of the derived essential oil...
- Isolation of halogenated monoterpenes from bioreactor-cultured microplantlets of the macrophytic red algae Ochtodes secundiramea and Portieria hornemanniiLuis F Barahona
CICY Biotecnologia, Apartado Postal 87, 97310 Cordemex, Merida, Mexico
J Nat Prod 66:743-51. 2003..This study demonstrated that bioreactor tissue culture is a new venue for bioprospecting and production of natural compounds from marine macroalgae under a controlled environment...
- Induction of volatile terpene biosynthesis and diurnal emission by methyl jasmonate in foliage of Norway spruceDiane M Martin
Biotechnology Laboratory, University of British Columbia, 6174 University Boulevard, Vancouver, British Columbia, Canada V6T 1Z3
Plant Physiol 132:1586-99. 2003..accumulation in needles without changes in terpene composition, much less than the 10- and 40-fold increases in monoterpenes and diterpenes, respectively, observed in wood tissue after MeJA treatment (D. Martin, D. Tholl, J...
- The role of genetic and chemical variation of Pinus sylvestris seedlings in influencing slug herbivoryJulianne M O'Reilly-Wapstra
School of Plant Science and CRC for Forestry, University of Tasmania, Private Bag 55, Hobart, TAS 7001, Australia
Oecologia 152:82-91. 2007..We also investigated the feeding responses of A. ater to artificial diets laced with two monoterpenes, Delta(3)-carene and alpha-pinene...
- Differential incorporation of 1-deoxy-D-xylulose into (3S)-linalool and geraniol in grape berry exocarp and mesocarpFang Luan
Institut fur Lebensmittelchemie, Biozentrum, Johann Wolfgang Goethe Universitat, Marie Curie Strasse 9, D 60439, Frankfurt, Germany
Phytochemistry 60:451-9. 2002..The results demonstrate that grape berries exhibit an autonomic monoterpene biosynthesis via the novel DOXP/MEP route throughout the ripening process...
- Seasonal variations of monoterpene emissions from coniferous trees of different ages in KoreaJo Chun Kim
Department of Environmental Engineering, Innovative Environmental Technology Centre, Konkuk University, Seoul 143 701, South Korea
Chemosphere 59:1685-96. 2005..obtusa. Higher monoterpene emission rates from each plant were found in spring and summer compared with autumn and winter emissions...
- Constituents of aromatic plants: eucalyptolM De Vincenzi
Department of Metabolism and Pathological Biochemistry ISS, Rome, Italy
Fitoterapia 73:269-75. 2002..Following the accidental exposure of human beings, death was reported in two cases after ingestion of 3.5-5 ml of essential eucalyptus oil, but a number of recoveries have also been described for much higher amounts of oil...
- A role for intra- and intercellular translocation in natural product biosynthesisToni M Kutchan
Leibniz Institut für Pflanzenbiochemie, Weinberg 3, 06120 Halle Saale, Germany
Curr Opin Plant Biol 8:292-300. 2005....
- Monoterpene regulation of Ras and Ras-related protein expressionSarah A Holstein
Departments of Pharmacology, University of Iowa, Iowa City, IA 52242, USA
J Lipid Res 44:1209-15. 2003b>Monoterpenes, derived primarily from plants, are products of the isoprenoid biosynthetic pathway and function as chemical messengers with diverse functions. The biochemical bases for these activities are largely undefined...
- Monoterpenes from thyme (Thymus vulgaris) as potential mosquito repellentsByeoung Soo Park
School of Agricultural Biotechnology, Seoul National University, Suwon 441 744, Korea
J Am Mosq Control Assoc 21:80-3. 2005Five monoterpenes (carvacrol, p-cymene, linalool, alpha-terpinene, and thymol) derived from the essential oil of thyme (Thymus vulgaris) were examined for their repellency against the mosquito Culex pipiens pallens...
- Patch testing with a new fragrance mix - reactivity to the individual constituents and chemical detection in relevant cosmetic productsPeter J Frosch
Department of Dermatology, Klinikum Dortmund gGmbH and University of Witten Herdecke, Germany
Contact Dermatitis 52:216-25. 2005..ROAT was performed with the concentration of the FM II which had produced a positive or doubtful (+ or ?+) patch test reaction. Patients' products were analysed for the 6 target compounds by gas chromatography-mass spectrometry (GC-MS)...
- Olfactory receptor neurons in two Heliothine moth species responding selectively to aliphatic green leaf volatiles, aromatic compounds, monoterpenes and sesquiterpenes of plant originT Røstelien
Neuroscience Unit, Department of Biology, Norwegian University of Science and Technology, NO 7489 Trondheim, Norway
Chem Senses 30:443-61. 2005..The specificity as well as the co-localization of particular neuron types so far recorded in both species showed similarities of the olfactory systems receiving plant odour information in these two species of heliothine moths...
- Antiinflammatory effects of euclyptol (1.8-cineole) in bronchial asthma: inhibition of arachidonic acid metabolism in human blood monocytes ex vivoU R Juergens
Abteilung Pneumologie, Medizinische Universitäts Poliklinik Bonn, Wilhelmstrasse 35 37, D 53111 Bonn, Germany
Eur J Med Res 3:407-12. 1998b>Monoterpenes are prescribed to treat chronic obstructive airway disorders mainly because of their familiar secretolytic properties. The aim of this study was to investigate the effect of 1...
- Anticonvulsant properties of linalool in glutamate-related seizure modelsE Elisabetsky
Departamento de Farmacologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Phytomedicine 6:107-13. 1999..Linalool partially inhibited and significantly delayed the behavioral expression of PTZ-kindling, but did not modify the PTZ-kindling-induced increase in L-[3H]glutamate binding...
- Dynamics of the enhanced emissions of monoterpenes and methyl salicylate, and decreased uptake of formaldehyde, by Quercus ilex leaves after application of jasmonic acidIolanda Filella
Unitat Ecofisiologia CSIC CEAB CREAF, Center for Ecological Research and Forestry Applications CREAF, Universitat Autonoma de Barcelona, 08193 Bellaterra Barcelona, Spain
New Phytol 169:135-44. 2006..Jasmonic acid-mediated increases in monoterpene and MeSa emissions might have a protective role when confronting biotic and abiotic stresses...
- Epidermis is a pivotal site of at least four secondary metabolic pathways in Catharanthus roseus aerial organsSamira Mahroug
Universite Francois Rabelais de Tours, EA 2106 Biomolécules et Biotechnologies Végétales UFR Sciences et Techniques, Parc de Grandmont, 37200 Tours, France
Planta 223:1191-200. 2006..g. flavonoïds, indoles, secoiridoid-monoterpenes and MIAs). These results, and data showing co-accumulation of flavonoids and alkaloids in single cells of C...
- Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channelsHaoxing Xu
Howard Hughes Medical Institute, Harvard Medical School, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
Nat Neurosci 9:628-35. 2006..Our results support a role for temperature-sensitive TRP channels in chemesthesis in oral and nasal epithelium and suggest that TRPV3 may be a molecular target of plant-derived skin sensitizers...
- Effect of physicochemical properties of cyclic terpenes on their ex vivo skin absorption and elimination kineticsKrzysztof Cal
Medical University of Gdansk, Department of Pharmaceutical Technology, Hallera 107, 80 416 Gdansk, Poland
J Dermatol Sci 41:137-42. 2006....
- A pharmacological profile of the aldehyde receptor repertoire in rat olfactory epitheliumRicardo C Araneda
Department of Biological Sciences, Columbia University, New York, NY 10027, USA
J Physiol 555:743-56. 2004..This large number of receptors for octanal suggests that, although the peripheral olfactory system is endowed with high sensitivity, discrimination among different compounds probably requires further central processing...
- Bioactive constituents of Chinese natural medicines. V. Radical scavenging effect of Moutan Cortex. (1): Absolute stereostructures of two monoterpenes, paeonisuffrone and paeonisuffralM Yoshikawa
Kyoto Pharmaceutical University, Japan
Chem Pharm Bull (Tokyo) 48:1327-31. 2000..Two monoterpenes called paeonisuffrone and paeonisuffral were isolated from the ethyl acetate-soluble fraction...
- Response properties of isolated mouse olfactory receptor cellsJ Reisert
Physiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
J Physiol 530:113-22. 2001..Second, the response to the second stimulus only recovered to 55% of its original magnitude, demonstrating the involvement of Na+-Ca2+ exchange in the recovery of sensitivity in mouse olfactory receptor cells following stimulation...
- The water-soluble components of the essential oil of Melaleuca alternifolia (tea tree oil) suppress the production of superoxide by human monocytes, but not neutrophils, activated in vitroC Brand
Department of Microbiology and Infectious Diseases, School of Medicine, Flinders University, Adelaide, Australia
Inflamm Res 50:213-9. 2001..CONCLUSION: Tea tree oil components suppress the production of superoxide by monocytes, but not neutrophils, suggesting the potential for selective regulation of cell types by these components during inflammation...
- Response of Plutella xylostella and its parasitoid Cotesia plutellae to volatile compoundsMohamed A Ibrahim
Department of Ecology and Environmental Science, University of Kuopio, Kuopio, Finland
J Chem Ecol 31:1969-84. 2005..The attractive effect of limonene and MeJA predicts that these two compounds can be used in sustainable plant protection strategies in organic farming...
- In vivo studies on the metabolism of the monoterpenes S-(+)- and R-(-)-carvone in humans using the metabolism of ingestion-correlated amounts (MICA) approachW Engel
Deutsche Forschungsanstalt fur Lebensmittelchemie, Lichtenbergstrasse 4, D 85748 Garching, Germany
J Agric Food Chem 49:4069-75. 2001..No differences in metabolism between S-(+)- and R-(-)-carvone were detected...
- CaaX-prenyltransferases are essential for expression of genes involvedin the early stages of monoterpenoid biosynthetic pathway in Catharanthus roseus cellsVincent Courdavault
Biomolecules et Biotechnologies Vegetales, Labaratoire de Physiologie Vegetale, UFR Science et Techniques, Universite Francois Rabelais de Tours, EA2106, 37200, Parc de Grandmont, Tours, France
Plant Mol Biol 57:855-70. 2005..We conclude that protein targets for both PFT and PGGT-I are required for the expression of ESMB genes and monoterpenoid biosynthesis in C. roseus, this represents a non previously described role for protein prenyltransferase in plants...
- Organization of monoterpene biosynthesis in Mentha. Immunocytochemical localizations of geranyl diphosphate synthase, limonene-6-hydroxylase, isopiperitenol dehydrogenase, and pulegone reductaseGlenn W Turner
Institute of Biological Chemistry, Washington State University, Pullman, Washington 99164, USA
Plant Physiol 136:4215-27. 2004..We discuss this pathway compartmentalization in relation to possible mechanisms for the intracellular movement of monoterpene metabolites, and for monoterpene secretion into the extracellular essential oil storage cavity...
- Anti-Tumor Mechanism of the MonoterpensHee Won Park; Fiscal Year: 2004Limonene and perillyl alcohol are monoterpenes that are dietary components as well as food flavoring agents and scent additives. Limonene is abundant in orange peel oil, and perillyl alcohol in cherry and spearmint...
- SYNTHESES OF NATURAL PRODUCTS BY CYCLOADDITION REACTIONSStephen Martin; Fiscal Year: 1990..condylocarpine, and strychnine; the Ajmaline and Sarpagine alkaloids quebrachidine and akuammidine; the iridoid monoterpenes loganin and secologanin, which are important biosynthetic precursors of the indole alkaloids and the iridoids, ..
- SPECIFICITY IN TERPENE AND STEROL BIOSYNTHESISRobert Coates; Fiscal Year: 1992..6. Determination of the stereochemistry and isotope effects of eliminations that terminate enzymatic cyclizations producing enantiomeric monoterpenes.
- Monoterpenes in Cancer Prevention and TherapyTimothy Vincent; Fiscal Year: 2005b>Monoterpenes are a class of phytochemicals that possess cancer preventative and therapeutic properties. The prototypical monoterpene Perillyl alcohol (POH) is currently in clinical trials for the treatment of cancers...
- Pancreatic Cancer Management by Novel Gene Therapy & Dietary AgentsPaul Fisher; Fiscal Year: 2009..Dietary monoterpenes, such as perillyl alcohol (POH) also exhibit anti- tumor properties...
- Pancreatic Cancer Management by Novel Gene Therapy & Dietary AgentsPaul B Fisher; Fiscal Year: 2010..Dietary monoterpenes, such as perillyl alcohol (POH) also exhibit anti- tumor properties...
- Anti-proliferative Effects of D-limonene against Prosta*Sanjay Gupta; Fiscal Year: 2005..Recent studies have shown that monoterpenes possess anticancer properties and suggest that these compounds represent a new class of agents for cancer ..
- CRCNS: Computational and experimental analysis of noradrenergic function in earlyChristiane Linster; Fiscal Year: 2010..Neuromodulation is involved in many major degenerative diseases of brain function;a better understanding of the functions of these systems will have a high impact on public health. ..
- CRCNS-Multiple olfactory gamma oscillations: roles in sensation and attentionLeslie Kay; Fiscal Year: 2007..We anticipate that understanding how olfactory deficits arise from changes in the limbic system associated with many of these disorders, will help us to understand the mechanisms that produce cognitive malfunctioning. ..
- Cholinergic modulation of olfactory processingChristiane Linster; Fiscal Year: 2007..These data should provide important insights into how neurodegenerative diseases affect olfactory sensation. ..
- CRCNS: Computational and experimental analysis of noradrenergic function in earlyChristiane Linster; Fiscal Year: 2007..Neuromodulation is involved in many major degenerative diseases of brain function; a better understanding of the functions of these systems will have a high impact on public health. ..
- OLFACTORY FUNCTION IN GENE-TARGETED MICEBurton Slotnick; Fiscal Year: 2002..A final report of these studies will incorporate a detailed description of apparatus, methods protocol and files of raw data and summary statistics presented in database and spreadsheet format. ..
- Cholinergic modulation of odor responsesChristiane Linster; Fiscal Year: 2003....
- OLFACTORY CODINGBurton Slotnick; Fiscal Year: 2003..Behavior tasks will use precision olfactometry. Anterograde transport of horseradish peroxidase will be used to assess connections between the olfactory epithelium and olfactory bulb in experimental rats. ..
- CRCNS: Computational and experimental analysis of noradrenergic function in earlyChristiane Linster; Fiscal Year: 2009..Neuromodulation is involved in many major degenerative diseases of brain function; a better understanding of the functions of these systems will have a high impact on public health. ..
- Oxidative Coupling in Natural Product SynthesisPhil Baran; Fiscal Year: 2007....
- Limits of Multi-Tetrode Intracortical MicrostimulationMARK LEHMKUHLE; Fiscal Year: 2006..This work is of potentially great relevance in the development and design of an electrical brain-machine interface capable of stimulating auditory cortex in such a manner as to artificially evoke auditory perceptions. ..
- Anti-Trypanosomal Agents from a Neotropical CloudforestWILLIAM SETZER; Fiscal Year: 2004..The long-term benefit of this research project is the development of new medicines to treat patients with Chagas disease. ..
- Nucleotide selectivity and drug resistance by HIV reverse transcriptaseKENNETH ALLEN JOHNSON; Fiscal Year: 2010....
- TRP Channel-Dependent Regulation of Arterial ToneScott Earley; Fiscal Year: 2010..The ultimate goal of this project is to improve human health by stimulating the development of new pharmaceuticals that act through TRPM4 to control and prevent cardiovascular-related diseases. ..
- Mechanism of mitochondrial DNA replicationKENNETH ALLEN JOHNSON; Fiscal Year: 2010....
- TRP Channel-Dependent Regulation of Arterial ToneScott Earley; Fiscal Year: 2009..The ultimate goal of this project is to improve human health by stimulating the development of new pharmaceuticals that act through TRPM4 to control and prevent cardiovascular-related diseases. ..
- TRPM4 Channels in the Control of Cerebral Artery ToneScott Earley; Fiscal Year: 2005..It is anticipated that these studies will generate significant new information regarding the role of mechanosensitive cation channels in the regulation of VSM membrane potential and the regulation of cerebral blood flow. ..
- MECHANISM AND FIDELITY OF DNA REPLICATIONKenneth Johnson; Fiscal Year: 2006..abstract_text> ..
- Elementary Steps in DNA PolymerizationKenneth Johnson; Fiscal Year: 2007..abstract_text> ..
- KINETIC ANALYSIS OF MICROTUBULE-DEPENDENT ATPASESKenneth Johnson; Fiscal Year: 2003..The combination of approaches outlined here will provide rigorous and direct information to define the structural and mechanistic basis for force production by kinesin. ..
- MECHANISM AND FIDELITY OF DNA REPLICATIONKenneth Johnson; Fiscal Year: 2003..The mechanism and fidelity of the mitochondrial polymerase will be established by kinetic measurements. ..