monoterpenes

Summary

Summary: Compounds with a core of 10 carbons generally formed via the mevalonate pathway from the combination of 3,3-dimethylallyl pyrophosphate and isopentenyl pyrophosphate. They are cyclized and oxidized in a variety of ways. Due to the low molecular weight many of them exist in the form of essential oils (OILS, VOLATILE).

Top Publications

  1. ncbi Monoterpene and sesquiterpene synthases and the origin of terpene skeletal diversity in plants
    Jörg Degenhardt
    Martin Luther University Halle Wittenberg, Institute for Pharmacy, Halle Saale, Germany
    Phytochemistry 70:1621-37. 2009
  2. pmc Terpenoid metabolism in wild-type and transgenic Arabidopsis plants
    Asaph Aharoni
    Plant Research International, 6700 AA, Wageningen, The Netherlands
    Plant Cell 15:2866-84. 2003
  3. pmc The phenolic hydroxyl group of carvacrol is essential for action against the food-borne pathogen Bacillus cereus
    A Ultee
    Wageningen Centre for Food Sciences, Department of Preservation Technology and Food Safety, Agrotechnological Research Institute ATO B V, Wageningen, The Netherlands
    Appl Environ Microbiol 68:1561-8. 2002
  4. ncbi Impact of ozone on monoterpene emissions and evidence for an isoprene-like antioxidant action of monoterpenes emitted by Quercus ilex leaves
    Francesco Loreto
    CNR Istituto di Biologia Agroambientale e Forestale, Monterotondo Scalo, Italy
    Tree Physiol 24:361-7. 2004
  5. ncbi Monoterpenes with analgesic activity--a systematic review
    Adriana G Guimarães
    Departamento de Fisiologia, Universidade Federal de Sergipe DFS UFS, Sao Cristovao, SE, Brazil
    Phytother Res 27:1-15. 2013
  6. ncbi De novo synthesis of monoterpenes by Saccharomyces cerevisiae wine yeasts
    Francisco M Carrau
    Seccion Enologia, Departmento de Ciencia y Tecnologia de Alimentos, Facultad de Quimica, Universidad de la Republica, 11800 Montevideo, Uruguay
    FEMS Microbiol Lett 243:107-15. 2005
  7. ncbi (-)-Linalool produces antinociception in two experimental models of pain
    Alessandra T Peana
    Dipartimento di Scienze del Farmaco, Universita degli Studi di Sassari, Via Muroni 23 A, 07100 Sassari, Italy
    Eur J Pharmacol 460:37-41. 2003
  8. ncbi Monoterpenoids induce agonist-specific desensitization of transient receptor potential vanilloid-3 (TRPV3) ion channels
    Muhammad Azhar Sherkheli
    Department of Cell Physiology, Ruhr University Bochum, Bochum 44801, Germany
    J Pharm Pharm Sci 12:116-28. 2009
  9. pmc Mechanisms of action of carvacrol on the food-borne pathogen Bacillus cereus
    A Ultee
    Agrotechnological Research Institute, 6700 AA Wageningen, The Netherlands
    Appl Environ Microbiol 65:4606-10. 1999
  10. pmc Identification of genes and proteins necessary for catabolism of acyclic terpenes and leucine/isovalerate in Pseudomonas aeruginosa
    Karin Förster-Fromme
    Institut fur Mikrobiologie, Universitat Stuttgart, Allmandring 31, 70550 Stuttgart, Germany
    Appl Environ Microbiol 72:4819-28. 2006

Detail Information

Publications277 found, 100 shown here

  1. ncbi Monoterpene and sesquiterpene synthases and the origin of terpene skeletal diversity in plants
    Jörg Degenhardt
    Martin Luther University Halle Wittenberg, Institute for Pharmacy, Halle Saale, Germany
    Phytochemistry 70:1621-37. 2009
    ....
  2. pmc Terpenoid metabolism in wild-type and transgenic Arabidopsis plants
    Asaph Aharoni
    Plant Research International, 6700 AA, Wageningen, The Netherlands
    Plant Cell 15:2866-84. 2003
    ..Most of the volatiles detected were monoterpenes and sesquiterpenes, which in contrast to other volatiles showed a diurnal emission pattern...
  3. pmc The phenolic hydroxyl group of carvacrol is essential for action against the food-borne pathogen Bacillus cereus
    A Ultee
    Wageningen Centre for Food Sciences, Department of Preservation Technology and Food Safety, Agrotechnological Research Institute ATO B V, Wageningen, The Netherlands
    Appl Environ Microbiol 68:1561-8. 2002
    ..The resulting collapse of the proton motive force and depletion of the ATP pool eventually lead to cell death...
  4. ncbi Impact of ozone on monoterpene emissions and evidence for an isoprene-like antioxidant action of monoterpenes emitted by Quercus ilex leaves
    Francesco Loreto
    CNR Istituto di Biologia Agroambientale e Forestale, Monterotondo Scalo, Italy
    Tree Physiol 24:361-7. 2004
    Quercus ilex (L.) leaves emit monoterpenes, particularly alpha-pinene, beta-pinene and sabinene...
  5. ncbi Monoterpenes with analgesic activity--a systematic review
    Adriana G Guimarães
    Departamento de Fisiologia, Universidade Federal de Sergipe DFS UFS, Sao Cristovao, SE, Brazil
    Phytother Res 27:1-15. 2013
    ..In the search for new therapeutic options, plants are a major source of novel biomolecules. Monoterpenes constitute 90% of essential oils, and there is a growing interest in understanding the mechanisms underlying ..
  6. ncbi De novo synthesis of monoterpenes by Saccharomyces cerevisiae wine yeasts
    Francisco M Carrau
    Seccion Enologia, Departmento de Ciencia y Tecnologia de Alimentos, Facultad de Quimica, Universidad de la Republica, 11800 Montevideo, Uruguay
    FEMS Microbiol Lett 243:107-15. 2005
    This paper reports the production of monoterpenes, which elicit a floral aroma in wine, by strains of the yeast Saccharomyces cerevisiae...
  7. ncbi (-)-Linalool produces antinociception in two experimental models of pain
    Alessandra T Peana
    Dipartimento di Scienze del Farmaco, Universita degli Studi di Sassari, Via Muroni 23 A, 07100 Sassari, Italy
    Eur J Pharmacol 460:37-41. 2003
    ..Finally, the activation of opioidergic and cholinergic systems appears to play a crucial role in (-)-linalool-induced antinociception...
  8. ncbi Monoterpenoids induce agonist-specific desensitization of transient receptor potential vanilloid-3 (TRPV3) ion channels
    Muhammad Azhar Sherkheli
    Department of Cell Physiology, Ruhr University Bochum, Bochum 44801, Germany
    J Pharm Pharm Sci 12:116-28. 2009
    ..In the present investigation TRPV3 was transiently expressed in either Xenopus oocytes or HEK293 cells. Whole-cell voltage-clamp techniques were used to characterize the behavior of TRPV3 when challenged with different agonists...
  9. pmc Mechanisms of action of carvacrol on the food-borne pathogen Bacillus cereus
    A Ultee
    Agrotechnological Research Institute, 6700 AA Wageningen, The Netherlands
    Appl Environ Microbiol 65:4606-10. 1999
    ..cereus by changing its permeability for cations like H(+) and K(+). The dissipation of ion gradients leads to impairment of essential processes in the cell and finally to cell death...
  10. pmc Identification of genes and proteins necessary for catabolism of acyclic terpenes and leucine/isovalerate in Pseudomonas aeruginosa
    Karin Förster-Fromme
    Institut fur Mikrobiologie, Universitat Stuttgart, Allmandring 31, 70550 Stuttgart, Germany
    Appl Environ Microbiol 72:4819-28. 2006
    ..A regulatory gene, atuR, was identified upstream of atuABCDEFGH and negatively regulated expression of the atu gene cluster...
  11. ncbi The influence of Ceratocystis polonica inoculation and methyl jasmonate application on terpene chemistry of Norway spruce, Picea abies
    Tao Zhao
    Ecological Chemistry Group, Department of Chemistry, Royal Institute of Technology, SE 100 44 Stockholm, Sweden
    Phytochemistry 71:1332-41. 2010
    ..Thus, terpene composition in the stem bark may be related to resistance of Norway spruce against I. typographus and C. polonica...
  12. pmc A pharmacological profile of the aldehyde receptor repertoire in rat olfactory epithelium
    Ricardo C Araneda
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    J Physiol 555:743-56. 2004
    ..This large number of receptors for octanal suggests that, although the peripheral olfactory system is endowed with high sensitivity, discrimination among different compounds probably requires further central processing...
  13. pmc Mechanisms of antibacterial action of three monoterpenes
    Domenico Trombetta
    Department Farmaco Biologico, School of Pharmacy, University of Messina, Contrada Annunziata, 98168 Messina, Italy
    Antimicrob Agents Chemother 49:2474-8. 2005
    In the present paper, we report the antimicrobial efficacy of three monoterpenes [linalyl acetate, (+)menthol, and thymol] against the gram-positive bacterium Staphylococcus aureus and the gram-negative bacterium Escherichia coli...
  14. ncbi Plant terpenes affect intensity and temporal parameters of pheromone detection in a moth
    Virginie Party
    Unité Mixte de Recherche 1272 Physiologie de l Insecte, Signalisation et Communication, Institut National de Recherche Agronomique, Universite Pierre et Marie Curie, Route de Saint Cyr, 78000 Versailles Cedex, France
    Chem Senses 34:763-74. 2009
    ..Ph-ORN responses of Spodoptera littoralis to the main pheromone component, Z9E11-14:Ac, in the presence of 4 monoterpenes. To mimic natural contexts in which plant odors and pheromone emanate from different sources, the 2 stimuli ..
  15. ncbi Monoterpenoid biosynthesis in Saccharomyces cerevisiae
    Marilyne Oswald
    UMR Santé de la Vigne et Qualité du Vin, Universite Louis Pasteur Strasbourg, Institut National de la Recherche Agronomique, Colmar, France
    FEMS Yeast Res 7:413-21. 2007
    ..We also showed that geraniol synthase expression affects the general ergosterol pathway, but in a manner dependent on the genetic background of the strain...
  16. ncbi Bioassay-guided evaluation of antioxidant and antinociceptive activities of carvacrol
    Adriana G Guimarães
    Department of Physiology, Federal University of Sergipe DFS UFS, Sao Cristovao, SE, Brazil
    Basic Clin Pharmacol Toxicol 107:949-57. 2010
    ..Together, these results indicate that the properties of CARV should be more thoroughly examined in order to achieve newer tools for management and/or treatment of painful conditions, including those related to pro-oxidant states...
  17. ncbi A novel heat-shock protein coinducer boosts stress protein Hsp70 to activate T cell regulation of inflammation in autoimmune arthritis
    Lotte Wieten
    Institute of Infectious Diseases and Immunology, Utrecht University, 3584 CL Utrecht, The Netherlands
    Arthritis Rheum 62:1026-35. 2010
    ..This study was undertaken to test the hypothesis that boosting of endogenous HSP expression can restore effective immunoregulation through T cells specific for stress proteins...
  18. ncbi Biosynthesis of mono- and sesquiterpenes in carrot roots and leaves (Daucus carota L.): metabolic cross talk of cytosolic mevalonate and plastidial methylerythritol phosphate pathways
    Daniela Hampel
    Institut fur Lebensmittelchemie, Johann Wolfgang Goethe Universitat, Marie Curie Strasse 9, D 60439 Frankfurt Main, Germany
    Phytochemistry 66:305-11. 2005
    The biosynthesis of the monoterpenes terpinolene and myrcene and the sesquiterpene beta-caryophyllene in roots and leaves of two carrot varieties (Daucus carota L...
  19. ncbi Defensive function of herbivore-induced plant volatile emissions in nature
    A Kessler
    Department of Molecular Ecology, Max-Planck-Institute for Chemical Ecology, Jena 07745, Germany
    Science 291:2141-4. 2001
    ..As a consequence, a plant could reduce the number of herbivores by more than 90% by releasing volatiles. These results confirm that indirect defenses can operate in nature...
  20. pmc Formation of monoterpenes in Antirrhinum majus and Clarkia breweri flowers involves heterodimeric geranyl diphosphate synthases
    Dorothea Tholl
    Max Planck Institute for Chemical Ecology, D 007745 Jena, Germany
    Plant Cell 16:977-92. 2004
    The precursor of all monoterpenes is the C10 acyclic intermediate geranyl diphosphate (GPP), which is formed from the C5 compounds isopentenyl diphosphate and dimethylallyl diphosphate by GPP synthase (GPPS)...
  21. ncbi Inhibitory activity of 1,8-cineol (eucalyptol) on cytokine production in cultured human lymphocytes and monocytes
    Uwe R Juergens
    Department of Pneumology, Allergology and Sleep Medicine, Medical Outpatient Clinic, Bonn University Hospital, Wilhelmestrasse 35 37, Bonn D 53111, Germany
    Pulm Pharmacol Ther 17:281-7. 2004
    ....
  22. pmc Proton-transfer-reaction mass spectrometry as a new tool for real time analysis of root-secreted volatile organic compounds in Arabidopsis
    Marco Steeghs
    Aeronomy Laboratory, National Oceanic and Atmospheric Administration, Boulder, Colorado 80305, USA
    Plant Physiol 135:47-58. 2004
    ..The PTR-MS method may open the way for functional root VOC analysis that will complement genomic investigations in Arabidopsis...
  23. ncbi Complex interactions among host pines and fungi vectored by an invasive bark beetle
    Min Lu
    State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    New Phytol 187:859-66. 2010
    ..valens and their pine hosts in China may confer advantages to these strains of L. procerum and, by extension, to the beetles themselves. These interactions may therefore enhance invasion by the beetle-fungal complex...
  24. ncbi Effects of carvacrol on defects of ischemia-reperfusion in the rat liver
    Mediha Canbek
    Department of Biology, Faculty of Science, Eskisehir Osmangazi University, 26480 Eskisehir, Turkey
    Phytomedicine 15:447-52. 2008
    ..05). Histological findings were in harmony with the biochemical results. We conclude that carvacrol protects the liver against defects caused by ischemia and reperfusion, and carvacrol is not hepatotoxic at the applied dosage...
  25. ncbi Anti-inflammation activity of fruit essential oil from Cinnamomum insularimontanum Hayata
    Chien Tsong Lin
    Department of Forestry, National Chung Hsing University, Taichung 402, Taiwan
    Bioresour Technol 99:8783-7. 2008
    ..The results presented that the fruit essential oil of C. insularimontanum and/or citral may have a great potential to develop the anti-inflammatory medicine in the future...
  26. ncbi Anti-proliferative effects of carvacrol on a human metastatic breast cancer cell line, MDA-MB 231
    K M Arunasree
    Institute of Life Sciences, University of Hyderabad Campus, Biology, Hyderabad 500 046, AP, India
    Phytomedicine 17:581-8. 2010
    ....
  27. ncbi Monoterpenes inhibit proliferation of human colon cancer cells by modulating cell cycle-related protein expression
    Sylvie Bardon
    Laboratoire de Nutrition et Securite Alimentaire, UR909, INRA, 78352 Cedex, Jouy en Josas, France
    Cancer Lett 181:187-94. 2002
    ..Analysis of G1 cell cycle regulators expression revealed that monoterpenes increased expression of cdk inhibitor p21(Waf1/Cip1) and cyclin E, and decreased expression of cyclin D1, ..
  28. pmc Linalool dehydratase-isomerase, a bifunctional enzyme in the anaerobic degradation of monoterpenes
    Danny Brodkorb
    Department of Microbiology, Max Planck Institute for Marine Microbiology, 28359 Bremen, Germany
    J Biol Chem 285:30436-42. 2010
    Castellaniella (ex Alcaligenes) defragrans strain 65Phen mineralizes monoterpenes in the absence of oxygen. Soluble cell extracts anaerobically catalyzed the isomerization of geraniol to linalool and the dehydration of linalool to myrcene...
  29. ncbi Synergistic effect of the interaction between naproxen and citral on inflammation in rats
    Mario I Ortiz
    Área Académica de Medicina del Instituto de Ciencias de la Salud, Universidad Autonoma del Estado de Hidalgo, Pachuca, Hidalgo, Mexico
    Phytomedicine 18:74-9. 2010
    ..The data suggests that the naproxen-citral combination can interact and to produce minor gastric damage and may have therapeutic advantages for the clinical treatment of inflammation...
  30. pmc Antimicrobial action of carvacrol at different stages of dual-species biofilm development by Staphylococcus aureus and Salmonella enterica serovar Typhimurium
    J R Knowles
    N terminus Research Laboratory, 981 Corporate Center Dr, Pomona, CA 91768, USA
    Appl Environ Microbiol 71:797-803. 2005
    ..0 mmol/h). These data show that carvacrol is an effective natural intervention to control dual-species biofilm formation...
  31. pmc Chemical signals associated with life inhibit necrophoresis in Argentine ants
    Dong Hwan Choe
    Department of Entomology, University of California, Riverside, CA 92521, USA
    Proc Natl Acad Sci U S A 106:8251-5. 2009
    ....
  32. ncbi Volatile organic components of fresh leaves as indicators of indigenous and cultivated citrus species in Taiwan
    Shu Yen Lin
    Department of Horticulture, National Taiwan University, Taiwei
    Biosci Biotechnol Biochem 74:806-11. 2010
    ..taiwanica was linked with sour orange, and either C. tachibana or C. depressa belonged to the mandarin group with C. tankan. Dendrograms also showed that the volatile patterns were related to the genetic classification...
  33. ncbi Physiological and physicochemical controls on foliar volatile organic compound emissions
    Ulo Niinemets
    Department of Plant Physiology, University of Tartu, Estonia
    Trends Plant Sci 9:180-6. 2004
    ..Because natural conditions always fluctuate, both physiological and physicochemical controls exert a major influence over plant volatile emissions...
  34. ncbi The effect of carvacrol on muscarinic receptors of guinea-pig tracheal chains
    M H Boskabady
    Department of Physiology and Pharmaceutical Research Centre, Medical School Mashhad University of Medical Sciences, Mashhad, Iran
    Phytother Res 25:530-5. 2011
    ..These results indicated an inhibitory effect of carvacrol on muscarinic receptors. A β-adrenoceptor stimulatory effect was also suggested for carvacrol...
  35. ncbi Spatial distribution and hormonal regulation of gene products from methyl erythritol phosphate and monoterpene-secoiridoid pathways in Catharanthus roseus
    Audrey Oudin
    EA 2106 Biomolécules et Biotechnologies Végétales, UFR des Sciences Pharmaceutiques, Universite Francois Rabelais de Tours, Tours, France
    Plant Mol Biol 65:13-30. 2007
    ..roseus cells, our results support that intercellular translocation likely plays an important role during monoterpene-secoiridoid assembly...
  36. ncbi Composition of the essential oil of Salvia officinalis L. from various European countries
    Ain Raal
    Institute of Pharmacy, University of Tartu, Estonia
    Nat Prod Res 21:406-11. 2007
    ..The comparatively high concentration of toxic thujones seem to be characteristic to sage leaves cultivated in Estonia...
  37. ncbi Relaxant effect of essential oil of Melissa officinalis and citral on rat ileum contractions
    H Sadraei
    Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
    Fitoterapia 74:445-52. 2003
    ..28 microM) in a concentration-dependent manner with a IC(50) of approximately 20 ng/ml. Citral also had a concentration-dependent inhibitory effect on contraction of rat ileum with IC(50)s comparable to that of MOEO...
  38. ncbi Bactericidal action of binary and ternary mixtures of carvacrol, thymol, and eugenol against Listeria innocua
    Rebeca García-García
    Dept de Ingeniería Química, Alimentos y Ambiental, Univ de las Américas Puebla, Cholula, Puebla 72820, Mexico
    J Food Sci 76:M95-100. 2011
    ..25, and 56.25 mg kg(-1), correspondingly, was the most effective for L. innocua inactivation. Several binary and ternary mixtures of these 3 natural antimicrobial agents worked adequately to inactivate L. innocua...
  39. ncbi Quinones and halogenated monoterpenes of algal origin show anti-proliferative effects against breast cancer cells in vitro
    Jo Anne de la Mare
    The Biomedical Biotechnology Research Unit BioBRU, Department of Biochemistry, Microbiology and Biotechnology, Rhodes University, P O Box 94, Grahamstown, 6140, South Africa
    Invest New Drugs 30:2187-200. 2012
    ..In addition, cell cycle analyses revealed that the compound causes G(1) arrest in MDA-MB-231 cells...
  40. ncbi Mechanisms of carvacrol-induced expression of type I collagen gene
    Jongsung Lee
    Biospectrum Life Science Institute, 101 701 SK Ventium, 522 Dangjung Dong, Gunpo City, 435 833 Gyunggi Do, Republic of Korea
    J Dermatol Sci 52:160-9. 2008
    ..Skin aging is accompanied by wrinkle formation and appears to be principally related to decreases in the levels of type I collagen, the primary component of the dermal layer of skin...
  41. ncbi Fumigant and contact toxicities of monoterpenes to Sitophilus oryzae (L.) and Tribolium castaneum (Herbst) and their inhibitory effects on acetylcholinesterase activity
    Samir A M Abdelgaleil
    Department of Pesticides Chemistry, Faculty of Agriculture, Alexandria University, 21545 El Shatby, Alexandria, Egypt
    J Chem Ecol 35:518-25. 2009
    A comparative study was conducted to assess the contact and fumigant toxicities of eleven monoterpenes on two important stored products insects--, Sitophilus oryzae, the rice weevil, and Tribolium castaneum, the rust red flour beetle...
  42. ncbi Changes in membrane fatty acids composition of microbial cells induced by addiction of thymol, carvacrol, limonene, cinnamaldehyde, and eugenol in the growing media
    Rosangela Di Pasqua
    Department of Food Science, Division of Microbiology, University of Naples Federico II, Via Universita 100, 80055 Portici, Italy
    J Agric Food Chem 54:2745-9. 2006
    ..All compounds influenced the fatty acid profile of B. thermosphacta, while Pseudomonas and S. aureus strains did not show substantial changes in their fatty acid compositions...
  43. ncbi Antifumonisin activity of natural phenolic compounds A structure-property-activity relationship study
    José S Dambolena
    Instituto Multidisciplinario de Biología Vegetal CONICET, Catedra de Quimica Organica, FCEFyN UNC, Avenida Vélez Sarsfield 1611, X5016GCA Córdoba Argentina
    Int J Food Microbiol 145:140-6. 2011
    ..These findings could provide an important contribution in the search for new compounds with antifumonisin activity...
  44. ncbi Catabolism of citronellol and related acyclic terpenoids in pseudomonads
    Karin Förster-Fromme
    Institut fur Mikrobiologie, Universitat Stuttgart, Allmandring 31, 70550, Stuttgart, Germany
    Appl Microbiol Biotechnol 87:859-69. 2010
    ..This minireview summarises knowledge on catabolic pathways and biotransformations of acyclic monoterpenes that have received only little attention...
  45. ncbi Effect of water stress and fungal inoculation on monoterpene emission from an historical and a new pine host of the mountain pine beetle
    Inka Lusebrink
    Department of Biological Sciences, University of Alberta, CW405 Biological Science Building, Edmonton, Alberta, T6G 2E9, Canada
    J Chem Ecol 37:1013-26. 2011
    ..into the experiment, water deficit seedlings of both species released significantly lower levels of total monoterpenes than well watered seedlings. Needle tissue contained lower total monoterpene content than bark...
  46. ncbi Influence of carvacrol on growth and toxin production by Bacillus cereus
    A Ultee
    Agrotechnological Research Institute ATO DLO, Wageningen, The Netherlands Wageningen Centre for Food Sciences, Wageningen, The Netherlands
    Int J Food Microbiol 64:373-8. 2001
    ..From this study it can be concluded that carvacrol can be added to food products at doses below the MIC value, thereby reducing the risk of toxin production by B. cereus and increasing the safety of the products...
  47. ncbi Antidepressant-like effect of carvacrol (5-Isopropyl-2-methylphenol) in mice: involvement of dopaminergic system
    Francisca Helvira Cavalcante Melo
    Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Rua Cel Nunes de Melo, Fortaleza, Brazil
    Fundam Clin Pharmacol 25:362-7. 2011
    ....
  48. ncbi Two nearly identical terpene synthases catalyze the formation of nerolidol and linalool in snapdragon flowers
    Dinesh A Nagegowda
    Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907, USA
    Plant J 55:224-39. 2008
    Terpenoids emitted from snapdragon flowers include three monoterpenes derived from geranyl diphosphate (GPP), myrcene, (E)-beta-ocimene and linalool, and a sesquiterpene, nerolidol, derived from farnesyl diphosphate (FPP)...
  49. ncbi Carvacrol prevents diet-induced obesity by modulating gene expressions involved in adipogenesis and inflammation in mice fed with high-fat diet
    Soomin Cho
    Department of Food and Nutrition, Brain Korea 21 Project, Yonsei University, Seoul 120 749, Korea
    J Nutr Biochem 23:192-201. 2012
    ....
  50. ncbi Volatile components of peel and leaf oils of lemon and lime species
    Marie Laure Lota
    Université de Corse, Equipe Chimie et Biomasse, UMR CNRS 6134, Route des Sanguinaires, 20000 Ajaccio, France
    J Agric Food Chem 50:796-805. 2002
    ..Four others were identified for lime leaf oils: beta-pinene/limonene; limonene/geranial/neral; limonene/linalool/citronellal; and limonene/sabinene/citronellal/linalool. These results were interpreted using principal component analysis...
  51. ncbi Antileukemia activity of perillyl alcohol (POH): uncoupling apoptosis from G0/G1 arrest suggests that the primary effect of POH on Bcr/Abl-transformed cells is to induce growth arrest
    S S Clark
    Department of Human Oncology, Oncology and the UW Comprehensive Cancer Center, University of Wisconsin, Madison, WI, USA
    Leukemia 16:213-22. 2002
    ....
  52. ncbi Coriander spice oil: effects of fruit crushing and distillation time on yield and composition
    B M Smallfield
    New Zealand Institute for Crop and Food Research Ltd, Invermay Agriculture Centre, Mosgiel, New Zealand
    J Agric Food Chem 49:118-23. 2001
    ..Crushing had little effect on linalool content, but distillation time could be manipulated to alter the linalool content of the oil...
  53. ncbi The 1-deoxy-D: -xylulose 5-phosphate synthase gene co-localizes with a major QTL affecting monoterpene content in grapevine
    Juri Battilana
    Department of Genetics and Molecular Biology, IASMA Research Center, Fondazione Edmund Mach, 38010 San Michele all Adige, Italy
    Theor Appl Genet 118:653-69. 2009
    ..From a chemical point of view, it is strongly related to the accumulation of monoterpenes in berries. However, knowledge of the genetic mechanisms underlying its regulation is still limited...
  54. ncbi Anxiolytic-like effect of Carvacrol (5-isopropyl-2-methylphenol) in mice: involvement with GABAergic transmission
    Francisca Helvira Cavalcante Melo
    Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Rua Cel Nunes de Melo 1127, 60430 270 Fortaleza, Brazil
    Fundam Clin Pharmacol 24:437-43. 2010
    ..These results show that CVC presents anxiolytic effects in the plus maze test which are not influenced by the locomotor activity in the open-field test...
  55. ncbi Interaction of four monoterpenes contained in essential oils with model membranes: implications for their antibacterial activity
    Mariateresa Cristani
    Department Farmaco Biologico, School of Pharmacy, University of Messina, Contrada Annunziata, 98168 Messina, Italy
    J Agric Food Chem 55:6300-8. 2007
    The present article reports the antimicrobial efficacy of four monoterpenes (thymol, carvacrol, p-cymene, and gamma-terpinene) against the Gram-positive bacterium Staphylococcus aureus and the Gram-negative bacterium Escherichia coli...
  56. ncbi Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes
    Mitsuo Miyazawa
    Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University, Kowakae, Higashiosaka, Osaka, Japan
    Drug Metab Dispos 30:602-7. 2002
    ..Species-related differences exist in the oxidations of limonenes in CYP2B subfamily in rats and humans...
  57. pmc Enhanced levels of the aroma and flavor compound S-linalool by metabolic engineering of the terpenoid pathway in tomato fruits
    E Lewinsohn
    Newe Ya ar Research Center, Agricultural Research Organization, Ramat Yishay 30095, Israel
    Plant Physiol 127:1256-65. 2001
    ..Our studies indicate that it is possible to enhance the levels of monoterpenes in ripening fruits by metabolic engineering.
  58. pmc A candidate gene association study on muscat flavor in grapevine (Vitis vinifera L.)
    Francesco Emanuelli
    Research and Innovation Center, Fondazione Edmund Mach Istituto Agrario di San Michele all Adige, Via E, Mach 1, 38010 San Michele all Adige TN, Italy
    BMC Plant Biol 10:241. 2010
    ..has up to now been studied by evaluating monoterpenoid levels through QTL analysis. These studies have revealed co-localization of 1-deoxy-D-xylulose 5-phosphate synthase (VvDXS) with the major QTL positioned on chromosome 5...
  59. ncbi An integrated genomic, proteomic and biochemical analysis of (+)-3-carene biosynthesis in Sitka spruce (Picea sitchensis) genotypes that are resistant or susceptible to white pine weevil
    Dawn E Hall
    Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada
    Plant J 65:936-48. 2011
    ..In conclusion, variation of the (+)-3-carene phenotype is controlled by copy number variation of PsTPS-3car genes, variation of gene and protein expression, and variation in catalytic efficiencies...
  60. ncbi Terpinen-4-ol, the main component of the essential oil of Melaleuca alternifolia (tea tree oil), suppresses inflammatory mediator production by activated human monocytes
    P H Hart
    Department of Microbiology and Infectious Diseases, School of Medicine, Flinders University, Adelaide, Australia
    Inflamm Res 49:619-26. 2000
    ..To evaluate potential antiinflammatory properties of tea tree oil, the essential oil steam distilled from the Australian native plant, Melaleuca alternifolia...
  61. ncbi Effects of oregano, carvacrol and thymol on Staphylococcus aureus and Staphylococcus epidermidis biofilms
    Antonia Nostro
    Dipartimento Farmaco Biologico, Facolta di Farmacia, Universita degli Studi di Messina, Villaggio Annunziata, 98168 Messina, Italy
    J Med Microbiol 56:519-23. 2007
    ..Subinhibitory concentrations of the oils attenuated biofilm formation of S. aureus and S. epidermidis strains on polystyrene microtitre plates...
  62. ncbi Real-time monitoring of herbivore induced volatile emissions in the field
    Andrea Schaub
    Ionicon Analytik GmbH, Technikerstrasse 21a, 6020 Innsbruck, Austria
    Physiol Plant 138:123-33. 2010
    ..However, there was a clear effect on SQT measurements. Elucidation of emission patterns in real-time is dependent upon the dynamics of cuvettes at different temperatures...
  63. ncbi Chemistry and biology of monoterpene indole alkaloid biosynthesis
    SARAH E O'CONNOR
    Department of Chemistry, Massachusetts Institute of Technology, Building 18 592, Cambridge, MA 02139 4307, USA
    Nat Prod Rep 23:532-47. 2006
  64. ncbi Optimization of the transient transformation of Catharanthus roseus cells by particle bombardment and its application to the subcellular localization of hydroxymethylbutenyl 4-diphosphate synthase and geraniol 10-hydroxylase
    Grégory Guirimand
    Universite Francois Rabelais de Tours, EA 2106 Biomolécules et Biotechnologies Végétales, IFR 135 Imagerie Fonctionnelle, 37200, Tours, France
    Plant Cell Rep 28:1215-34. 2009
    ..Furthermore, we also demonstrated that G10H is an ER-anchored protein, consistent with the presence of a transmembrane helix at the G10H N-terminal end, which is both necessary and sufficient to drive the ER anchoring...
  65. pmc Differential timing of spider mite-induced direct and indirect defenses in tomato plants
    Merijn R Kant
    Institute for Biodiversity and Ecosystem Dynamics, Department of Plant Physiology, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    Plant Physiol 135:483-95. 2004
    ..Although transcriptional up-regulation of the enzymes involved in the biosynthesis of monoterpenes and diterpenes already occurred on day one, a significant increase in the emission of volatile terpenoids was ..
  66. ncbi cDNA isolation, functional expression, and characterization of (+)-alpha-pinene synthase and (-)-alpha-pinene synthase from loblolly pine (Pinus taeda): stereocontrol in pinene biosynthesis
    Michael A Phillips
    Institute of Biological Chemistry, Washington State University, Pullman, WA 99164 6340, USA
    Arch Biochem Biophys 411:267-76. 2003
    The complex mixture of monoterpenes, sesquiterpenes, and diterpenes that comprises oleoresin provides the primary defense of conifers against bark beetles and their associated fungal pathogens...
  67. ncbi Anticonvulsant properties of linalool in glutamate-related seizure models
    E Elisabetsky
    Departamento de Farmacologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Phytomedicine 6:107-13. 1999
    ..Linalool partially inhibited and significantly delayed the behavioral expression of PTZ-kindling, but did not modify the PTZ-kindling-induced increase in L-[3H]glutamate binding...
  68. pmc Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels
    Moshe Parnas
    Department of Physiology, Kühne Minerva Center for Studies of Visual Transduction, Faculty of Medicine, The Hebrew University, Jerusalem 91120, Israel
    Cell Calcium 45:300-9. 2009
    ..Our finding that the activity of the non-thermoTRPs, TRPL and TRPM7 channels is modulated by the same compound as thermoTRPs, suggests that common mechanisms of channel modulation characterize TRP channels...
  69. pmc Carvacrol, a component of thyme oil, activates PPARalpha and gamma and suppresses COX-2 expression
    Mariko Hotta
    Department of Food Science and Nutrition, Nara Women s University Nara 630 8506 Japan
    J Lipid Res 51:132-9. 2010
    ..These results may be important in understanding the antiinflammatory and antilifestyle-related disease properties of carvacrol...
  70. ncbi Comparative study on the antiviral activity of selected monoterpenes derived from essential oils
    Akram Astani
    Department of Virology, Hygiene Institute, University of Heidelberg, Heidelberg, Germany
    Phytother Res 24:673-9. 2010
    ..These essential oils were able to reduce viral infectivity by >96%, the monoterpenes inhibited HSV by about >80%...
  71. ncbi Inhibition of membrane bound ATPases of Escherichia coli and Listeria monocytogenes by plant oil aromatics
    A O Gill
    Department of Food Science, Faculty of Agriculture and Food Sciences, 250 Ellis Building, 13 Freedman Crescent, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
    Int J Food Microbiol 111:170-4. 2006
    ..The percent partitioning of E. coli was significantly greater than both other organisms (23.3%) and may explain the greater sensitivity of E. coli to all three aromatics...
  72. pmc Alpha-thujone (the active component of absinthe): gamma-aminobutyric acid type A receptor modulation and metabolic detoxification
    K M Höld
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, 114 Wellman Hall, University of California, Berkeley, CA 94720 3112, USA
    Proc Natl Acad Sci U S A 97:3826-31. 2000
    ..The other metabolites assayed are also detoxification products. Thus, alpha-thujone in absinthe and herbal medicines is a rapid-acting and readily detoxified modulator of the GABA-gated chloride channel...
  73. pmc Hsp70 expression and induction as a readout for detection of immune modulatory components in food
    Lotte Wieten
    Department of Infectious Diseases and Immunology, Utrecht University, The Netherlands
    Cell Stress Chaperones 15:25-37. 2010
    ..These assay systems are generally applicable to identify compounds that affect the Hsp level in cells of the immune system...
  74. pmc Carvacrol induces heat shock protein 60 and inhibits synthesis of flagellin in Escherichia coli O157:H7
    Sara A Burt
    Institute for Risk Assessment Sciences, Division of Veterinary Public Health, Faculty of Veterinary Medicine, Utrecht University, 3508TD Utrecht, The Netherlands
    Appl Environ Microbiol 73:4484-90. 2007
    ..This study is the first to demonstrate that essential oil components induce HSP60 in bacteria and that overnight incubation with carvacrol prevents the development of flagella in E. coli O157:H7...
  75. ncbi Fungicidal activity of thymol and carvacrol by disrupting ergosterol biosynthesis and membrane integrity against Candida
    A Ahmad
    Department of Biosciences, Jamia Millia Islamia, New Delhi, India
    Eur J Clin Microbiol Infect Dis 30:41-50. 2011
    ..The mechanisms of action of these natural isopropyl cresols appear to originate from the inhibition of ergosterol biosynthesis and the disruption of membrane integrity...
  76. pmc The capacity for thermal protection of photosynthetic electron transport varies for different monoterpenes in Quercus ilex
    Lucian O Copolovici
    Department of Plant Physiology, Institute of Molecular and Cell Biology, University of Tartu, Estonia
    Plant Physiol 139:485-96. 2005
    ..these data contribute to the hypothesis of the antioxidative protection of leaf membranes during heat stress by monoterpenes. These data further suggest that fumigation with the relatively low atmospheric concentrations of monoterpenes ..
  77. ncbi Hydroxydicarboxylic acids: markers for secondary organic aerosol from the photooxidation of alpha-pinene
    Magda Claeys
    Department of Pharmaceutical Sciences, University of Antwerp Campus Drie Eiken, Universiteitsplein 1, BE 2610 Antwerp, Belgium
    Environ Sci Technol 41:1628-34. 2007
    ..The detection of 2-hydroxy-4-isopropyladipic acid in ambient aerosol provides an explanation for the relatively low atmospheric concentrations of pinic acid found during daytime in forest environments...
  78. ncbi Synergistic blends of monoterpenes for aggregation pheromones of the mountain pine beetle (Coleoptera: Curculionidae)
    John H Borden
    Contech Inc, 7572 Progress Way, Delta, BC, Canada
    J Econ Entomol 101:1266-75. 2008
    ..Among host pines, the presence of highly synergistic monoterpenes at various levels in combination with other monoterpenes that are apparently either inert or inhibitory could ..
  79. ncbi Encapsulation of nutraceutical monoterpenes in beta-cyclodextrin and modified starch
    I Mourtzinos
    Laboratory of Food Chemistry, Biochemistry and Physical Chemistry, Department of Nutrition and Dietetics, Harokopio University, 70 El Venizelou Ave, Kallithea, 176 71, Athens, Greece
    J Food Sci 73:S89-94. 2008
    ..Oxidative DSC revealed that the monoterpenes enclosed in the beta-CD cavity were protected against oxidation, remaining intact in temperatures at which free ..
  80. ncbi Screening of chemical composition and antifungal and antioxidant activities of the essential oils from three Turkish artemisia species
    Saban Kordali
    Department of Plant Protection, Faculty of Agriculture, Kazim Karabekir Education Faculty, Ataturk University, 25240 Erzurum, Turkey
    J Agric Food Chem 53:1408-16. 2005
    ..All of the studied essential oils showed antioxidant activity, but camphor and 1,8-cineole did not...
  81. ncbi Effect of photon flux density and temperature on the production of halogenated monoterpenes by Plocamium cartilagineum (Plocamiaceae, Rhodophyta)
    Rodrigo Palma
    Facultad de Ciencias del Mar, Universidad Catolica del Norte, Coquimbo, Chile
    Z Naturforsch C 59:679-83. 2004
    ..densities (PFD) and temperatures on the relative growth rate (RGR) and the concentration of three halogenated monoterpenes in samples of Plocamium cartilagineum L.( Dixon), a marine alga (Rhodophyceae), were studied...
  82. ncbi Discrepancy between antennal and behavioral responses for enantiomers of alpha-pinene: electrophysiology and behavior of Helicoverpa armigera (Lepidoptera)
    C D Hull
    Centre for Microscopy and Microanalysis, The University of Queensland, Brisbane, 4072, Australia
    J Chem Ecol 30:2071-84. 2004
    ..g., phenylacetaldehyde versus (-)-alpha-pinene) in learning experiments. The relevance of receptor discrimination of enantiomers and learning ability of the moths in host plant choice is discussed...
  83. ncbi Inhibitory effect of citral on NO production by suppression of iNOS expression and NF-kappa B activation in RAW264.7 cells
    Hwa Jeong Lee
    College of Pharmacy, Chungbuk National University, 48, Gaeshin dong, Heungduk gu, Cheongju, Chungbuk 361 763, Korea
    Arch Pharm Res 31:342-9. 2008
    ..These results suggest that citral is anti-inflammatory, and its effects may be due to the inhibition of NO production through the suppression of NF-kappa B activation...
  84. ncbi Effects of nucleo-cytoplasmic interactions on leaf volatile compounds from citrus somatic diploid hybrids
    Anne Laure Fanciullino
    Département FLHOR, Centre de Cooperation Internationale en Recherche Agronomique pour le Developpement CIRAD, TA50 16, F 34398 Montpellier cedex 5, France
    J Agric Food Chem 53:4517-23. 2005
    ....
  85. ncbi Disruption of Escherichia coli, Listeria monocytogenes and Lactobacillus sakei cellular membranes by plant oil aromatics
    A O Gill
    Department of Food Science, Faculty of Agriculture and Food Sciences, 250 Ellis Building, 13 Freedman Crescent, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
    Int J Food Microbiol 108:1-9. 2006
    ..Secondary effects would also be consistent with membrane disruption...
  86. ncbi Polar organic marker compounds in PM2.5 aerosol from a mixed forest site in western Germany
    Ivan Kourtchev
    Department of Pharmaceutical Sciences, University of Antwerp Campus Drie Eiken, Universiteitsplein 1, BE 2610 Antwerp, Belgium
    Chemosphere 73:1308-14. 2008
    ..In addition, the occurrence of levoglucosan and pyrogallol indicates that the site is affected by biomass combustion. Their median concentrations were 30 and 8.9 ng m(-3), respectively...
  87. ncbi [Study on the essential oil components in Thymus quinquecostatus Celak]
    G Y Chen
    Department of Chemistry, Hainan Normal University, Haikou 571158, China
    Yao Xue Xue Bao 36:233-4. 2001
    ..To analyse the essential oil components of Thymus quinquecostatus Celak...
  88. ncbi Repellent activities of essential oils and monoterpenes against Culex pipiens pallens
    Won Sik Choi
    Department of Life Science, Soonchunhyang University, Asan, Chungnam 337 745, Republic of Korea
    J Am Mosq Control Assoc 18:348-51. 2002
    ..With gas chromatography-mass spectrometry analysis, thyme essential oil was a rich source of 5 monoterpenes, including in descending order thymol, p-cymene, carvacrol, linalool, and alpha-terpinene...
  89. ncbi The role of monoterpenes in resistance of Douglas fir to western spruce budworm defoliation
    Zhong Chen
    School of Forestry, Northern Arizona University, Flagstaff 86011 5018, USA
    J Chem Ecol 28:897-920. 2002
    ..Franco var. glauca] to assess the role of monoterpenes as a resistance mechanism to western spruce budworm (Choristoneura occidentalis Freeman) defoliation...
  90. ncbi Challenges posed to bornyl diphosphate synthase: diverging reaction mechanisms in monoterpenes
    Michal Weitman
    Department of Chemistry and the Lise Meitner Minerva Center of Computational Quantum Chemistry, Bar Ilan University, Ramat Gan 52900, Israel
    J Am Chem Soc 132:6349-60. 2010
    The simplest form of terpenoid chemistry is found for the monoterpenes, which give plants fragrance, flavor, and medicinal properties...
  91. ncbi Responses of bark beetle-associated bacteria to host monoterpenes and their relationship to insect life histories
    Aaron S Adams
    Department of Entomology, University of Wisconsin Madison, 1630 Linden Dr, Madison, WI 53706, USA
    J Chem Ecol 37:808-17. 2011
    ..A substantial literature exists on how monoterpenes affect bark beetles and their associated fungi, but little is known of how they affect bacteria, which in turn ..
  92. ncbi Seasonal influence on gene expression of monoterpene synthases in Salvia officinalis (Lamiaceae)
    Sabine Grausgruber-Gröger
    Institute for Applied Botany and Pharmacognosy, University of Veterinary Medicine, Veterinarplatz 1, 1210 Vienna, Austria
    J Plant Physiol 169:353-9. 2012
    ..It is mainly composed of the monoterpenes 1,8-cineole, α- and β-thujone and camphor synthesized by the 1,8-cineole synthase, the (+)-sabinene synthase ..
  93. ncbi Leaf volatile compounds of seven citrus somatic tetraploid hybrids sharing willow leaf mandarin (Citrus deliciosa Ten.) as their common parent
    Anne Laure Gancel
    Centre de Cooperation Internationale en Recherche Agronomique pour le Developpement CIRAD, Département FLHOR, TA50 16, F 34398 Montpellier cedex 5, France
    J Agric Food Chem 51:6006-13. 2003
    ..Statistical analyses showed that all of the hybrids were similar to their common mandarin parent in the relative composition of their volatile compounds...
  94. ncbi Potential preventive effect of carvacrol against diethylnitrosamine-induced hepatocellular carcinoma in rats
    Subramaniyan Jayakumar
    Department of Biochemistry, University of Madras, Guindy Campus, Chennai, Tamilnadu, India
    Mol Cell Biochem 360:51-60. 2012
    ..These findings suggest that carvacrol prevents lipid peroxidation, hepatic cell damage, and protects the antioxidant system in DEN-induced hepatocellular carcinogenesis...
  95. ncbi Knockdown and larvicidal activity of six monoterpenes against Aedes aegypti (Diptera: Culicidae) and their structure-activity relationships
    Alejandro Lucia
    Centro de Investigaciones de Plagas e Insecticidas CIPEIN UNIDEF MINDEF CONICET, Juan Bautista de La Salle 4397, 1603, Buenos Aires Province, Villa Martelli, Argentina
    Parasitol Res 112:4267-72. 2013
    ..Diptera: Culicidae). The octanol-water partition coefficients of the monoterpenes were estimated by the atom/fragment contribution method and the vapor pressures were determined by our ..
  96. ncbi Effect of naturally occurring monoterpenes carvone, limonene and perillic acid in the inhibition of experimental lung metastasis induced by B16F-10 melanoma cells
    T J Raphael
    Amala Cancer Research Centre, Amala Nagar, Kerala, India
    J Exp Clin Cancer Res 22:419-24. 2003
    The effects of naturally occurring monoterpenes on lung metastasis induced by B16F-10 melanoma cells were studied in C57BL/6 mice. Administration of monoterpenes such as limonene (100 micromoles/kg body wt. 10 doses i.p...
  97. ncbi Metabolic engineering of plant monoterpenes, sesquiterpenes and diterpenes--current status and future opportunities
    B Markus Lange
    Institute of Biological Chemistry and MJ Murdock Metabolomics Laboratory, Washington State University, Pullman, WA, USA
    Plant Biotechnol J 11:169-96. 2013
    ..In this review article, we will evaluate the state of the art of modulating the biosynthetic pathways for the production of mono-, sesqui- and diterpenes in plants...
  98. ncbi Myrtenal inhibits acetylcholinesterase, a known Alzheimer target
    Dorothea Kaufmann
    Institute of Pharmacy and Molecular Biotechnology, Department of Biology, Ruprecht Karls University Heidelberg, Heidelberg, Germany
    J Pharm Pharmacol 63:1368-71. 2011
    ..In this study selected components of essential oils, which carry a variety of important functional groups, were tested for their in-vitro anti-acetylcholinesterase activity...
  99. ncbi Identification and quantification of aerosol polar oxygenated compounds bearing carboxylic or hydroxyl groups. 2. Organic tracer compounds from monoterpenes
    M Jaoui
    Alion Science and Technology, P O Box 12313, Research Triangle Park, North Carolina 27709, USA
    Environ Sci Technol 39:5661-73. 2005
    ..NC, during the summer of 2003, and the laboratory samples originated from the photooxidation of the following monoterpenes: alpha-pinene, beta-pinene, and d-limonene...
  100. ncbi Modulation of genotoxicity and DNA repair by plant monoterpenes camphor, eucalyptol and thujone in Escherichia coli and mammalian cells
    Biljana Nikolic
    University of Belgrade, Faculty of Biology, Chair of Microbiology, Studentski trg 3 II, 11000 Belgrade, Serbia
    Food Chem Toxicol 49:2035-45. 2011
    The aim of this work was to examine the antigenotoxic potential of plant monoterpenes: camphor, eucalyptol and thujone in prokaryotic and eukaryotic cells and to elucidate their effect on DNA repair...
  101. ncbi Purification and identification of carvacrol from the root of Stellera chamaejasme and research on its insecticidal activity
    Xiaorong Tang
    College of Physics and Chemistry, Xihua University, Chengdu 610039, PR China
    Nat Prod Res 25:320-5. 2011
    ..Its median lethal concentrations (LC(50)) (24 h after treatment) were 16.8 and 12.7 mg L(-1), respectively. This is the first report of the insecticidal activity of carvacrol against A. craccivora and L. separata...

Research Grants49

  1. Anti-Tumor Mechanism of the Monoterpens
    Hee Won Park; Fiscal Year: 2004
    Limonene and perillyl alcohol are monoterpenes that are dietary components as well as food flavoring agents and scent additives. Limonene is abundant in orange peel oil, and perillyl alcohol in cherry and spearmint...
  2. Clinical Study of Disposition and Biological Activity of d-Limonene
    H H Sherry Chow; Fiscal Year: 2010
    ..Most clinical development efforts of monocyclic monoterpenes have focused on a hydroxylated analog of limonene, perillyl alcohol...
  3. Pancreatic Cancer Management by Novel Gene Therapy &Dietary Agents
    Paul B Fisher; Fiscal Year: 2012
    ..Dietary monoterpenes, such as perillyl alcohol (POH) also exhibit anti- tumor properties...
  4. MOLECULAR BASIS OF SELECTIVE P450 2B FUNCTION
    James R Halpert; Fiscal Year: 2013
    ..the proposed research is to determine how human hepatic CYP2B6 can bind and oxidize small hydrocarbons such as monoterpenes (C10H16) efficiently and selectively in the absence of any functional groups in the compounds that can make ..
  5. Total Synthesis of Plocamium Polyhalogenated Monoterpenes, Analogues, and Biologi
    Carl Vogel; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Plocamium polyhalogenated monoterpenes are metabolites first isolated from the red algae Plocamium cartilagineum, featuring several units of unsaturation, as well as multiple halogens, including two ..
  6. Methylerythritol Phosphate Pathway Inhibitors Targeting Gram-Negative Infections
    CHARLES TESTA; Fiscal Year: 2009
    ..classes of natural products with a multitude of structural features and ranging in size from the ten-carbon monoterpenes to natural rubber with a molecular weight as high as 1.5 million...
  7. Methylerythritol Phosphate Pathway-Specific Natural Products as Antibacterials
    CHARLES TESTA; Fiscal Year: 2009
    ..Representing one of the most diverse classes of natural products, isoprenoids range in size from ten-carbon monoterpenes to natural rubber (molecular weight 1...
  8. A Supramolecular Coordination Cluster as a Functional Monoterpene Synthase Mimic.
    JASON MICHAEL NICHOLS; Fiscal Year: 2010
    ..Binding of acyclic terpene precursors within the complex's negatively-charged cavity will catalyze their cationic cyclization to the p-menthane family of monoterpenoids in a biomimetic fashion. ..
  9. THE TOTAL SYNTHESIS OF SARRACENIN
    JAMES WHITESELL; Fiscal Year: 1980
    Sarracenin and xylomollin are closely related, naturally occurring monoterpenes. The latter exhibits a number of biochemically interesting properties, the most important being a pronounced ability to inhibit respiration in rat liver ..
  10. Monoterpenes in Cancer Prevention and Therapy
    Timothy Vincent; Fiscal Year: 2005
    b>Monoterpenes are a class of phytochemicals that possess cancer preventative and therapeutic properties. The prototypical monoterpene Perillyl alcohol (POH) is currently in clinical trials for the treatment of cancers...
  11. Anti-proliferative Effects of D-limonene against Prosta*
    Sanjay Gupta; Fiscal Year: 2005
    ..Recent studies have shown that monoterpenes possess anticancer properties and suggest that these compounds represent a new class of agents for cancer ..
  12. PERILLYL ALCOHOL THERAPY IN ADVANCED COLORECTAL CANCER
    James Thomas; Fiscal Year: 1999
    ..As a class of agents, the monoterpenes are active in several different in vivo and in vitro cancer model systems...
  13. Cholinergic modulation of odor responses
    Christiane Linster; Fiscal Year: 2003
    ....
  14. OLFACTORY CODING
    Burton Slotnick; Fiscal Year: 2003
    ..Behavior tasks will use precision olfactometry. Anterograde transport of horseradish peroxidase will be used to assess connections between the olfactory epithelium and olfactory bulb in experimental rats. ..
  15. Cholinergic modulation of olfactory processing
    Christiane Linster; Fiscal Year: 2007
    ..These data should provide important insights into how neurodegenerative diseases affect olfactory sensation. [unreadable] [unreadable] [unreadable]..
  16. CRCNS-Multiple olfactory gamma oscillations: roles in sensation and attention
    Leslie Kay; Fiscal Year: 2008
    ..We anticipate that understanding how olfactory deficits arise from changes in the limbic system associated with many of these disorders, will help us to understand the mechanisms that produce cognitive malfunctioning. ..
  17. CRCNS: Computational and experimental analysis of noradrenergic function in early
    Christiane Linster; Fiscal Year: 2010
    ..Neuromodulation is involved in many major degenerative diseases of brain function;a better understanding of the functions of these systems will have a high impact on public health. ..
  18. OLFACTORY FUNCTION IN GENE-TARGETED MICE
    Burton Slotnick; Fiscal Year: 2002
    ..A final report of these studies will incorporate a detailed description of apparatus, methods protocol and files of raw data and summary statistics presented in database and spreadsheet format. ..
  19. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2008
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  20. Breast Cancer Risk Biomarkers and Energy Balance
    CAROL FABIAN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  21. Breast Cancer Prevention by Letrozole in High Risk Women
    Carol J Fabian; Fiscal Year: 2010
    ....
  22. Mechanisms of Human Flavor Perception
    Lawrence E Marks; Fiscal Year: 2010
    ..A better understanding of flavor perception could contribute to the treatment of disorders of eating, nutrition, and body weight. ..
  23. Oxidative Coupling in Natural Product Synthesis
    Phil Baran; Fiscal Year: 2009
    ....
  24. Gating Mechanisms of CLC Chloride Channels
    Tsung Yu Chen; Fiscal Year: 2008
    ..abstract_text> ..
  25. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..
  26. Total Synthesis of Anti-Cancer Natural Products
    Phil S Baran; Fiscal Year: 2010
    ..New strategies and methods in chemistry and substantial contributions to medicine are anticipated through strategic collaborations with several leaders in the field of cancer biology. ..
  27. Radioisotope Therapy Targeting the Somatostatin Receptor
    Gina Chung; Fiscal Year: 2003
    ..These translational studies will serve as the basis for expanding a novel therapeutic modality for neuroendocrine cancers. ..
  28. Improved Use of Camptothecins for Small Cell Lung Cancer
    John Murren; Fiscal Year: 2004
    ..The data generated by these studies will provide additional insight into clinically relevant mechanisms of resistance to camptothecin that occur in SCLC. ..
  29. FlaxSeed Lignan for Breast Cancer Chemoprevention
    CAROL FABIAN; Fiscal Year: 2007
    ..If positive, the results of this study will be critical to the design and implementation of a placebo-controlled Phase II prevention trial with Brevail and/or commercial flaxseed. [unreadable] [unreadable]..
  30. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2002
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
  31. CHEMOPREVENTION FOR WOMEN AT HIGH RISK OF BREAST CANCER
    CAROL FABIAN; Fiscal Year: 2003
    ..The answer impacts on the entire future of breast cancer chemoprevention development efforts. ..
  32. ANTILEUKEMIA ACTIVITY OF PERILLYL ALCOHOL
    Steven Clark; Fiscal Year: 2003
    ..abstract_text> ..
  33. Spatial-Temporal Responses of Olfactory Bulb Neurons
    MARK LEHMKUHLE; Fiscal Year: 2003
    ..abstract_text> ..
  34. COMMONALITIES IN TOUCH, HEARING,VISION AND TASTE
    Lawrence Marks; Fiscal Year: 2004
    ....
  35. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  36. CONTEXT EFFECTS IN THE PERCEPTION OF SENSORY MAGNITUDE
    Lawrence Marks; Fiscal Year: 2001
    ....
  37. Synaptic connectivity in mouse accessory olfactory bulb
    Ricardo Araneda; Fiscal Year: 2005
    ..It is anticipated that these studies will have an impact on our understanding of the sensory coding of pheromonal information and other olfactory information by the accessory olfactory system. ..
  38. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005
    ..abstract_text> ..
  39. Replacing Pierce Lab Animal Care Air Handling Facility
    Lawrence Marks; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  40. Mechanisms of Taste- & Taste-Olfaction Mixture Detection
    Lawrence Marks; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  41. ENZYMATIC CYCLIZATION TO TERPENOID NATURAL PRODUCTS
    Rodney Croteau; Fiscal Year: 2007
    ..unreadable]..
  42. Anti-Trypanosomal Agents from a Neotropical Cloudforest
    WILLIAM SETZER; Fiscal Year: 2004
    ..The long-term benefit of this research project is the development of new medicines to treat patients with Chagas disease. ..
  43. Limits of Multi-Tetrode Intracortical Microstimulation
    MARK LEHMKUHLE; Fiscal Year: 2006
    ..This work is of potentially great relevance in the development and design of an electrical brain-machine interface capable of stimulating auditory cortex in such a manner as to artificially evoke auditory perceptions. ..
  44. Elementary Steps in DNA Polymerization
    Kenneth Johnson; Fiscal Year: 2008
    ..abstract_text> ..
  45. TRPM4 Channels in the Control of Cerebral Artery Tone
    Scott Earley; Fiscal Year: 2005
    ..It is anticipated that these studies will generate significant new information regarding the role of mechanosensitive cation channels in the regulation of VSM membrane potential and the regulation of cerebral blood flow. ..
  46. KINETIC ANALYSIS OF MICROTUBULE-DEPENDENT ATPASES
    Kenneth Johnson; Fiscal Year: 2003
    ..The combination of approaches outlined here will provide rigorous and direct information to define the structural and mechanistic basis for force production by kinesin. ..