monoterpenes

Summary

Summary: Compounds with a core of 10 carbons generally formed via the mevalonate pathway from the combination of 3,3-dimethylallyl pyrophosphate and isopentenyl pyrophosphate. They are cyclized and oxidized in a variety of ways. Due to the low molecular weight many of them exist in the form of essential oils (OILS, VOLATILE).

Top Publications

  1. ncbi Asaricin, the main component of Ocotea opifera Mart. essential oil
    D Lorenzo
    Catedra de Farmacognosia y Productos Naturales, , General Montevideo, Uruguay
    Nat Prod Lett 15:163-70. 2001
  2. ncbi The influence of Ceratocystis polonica inoculation and methyl jasmonate application on terpene chemistry of Norway spruce, Picea abies
    Tao Zhao
    Ecological Chemistry Group, Department of Chemistry, Royal Institute of Technology, SE 100 44 Stockholm, Sweden
    Phytochemistry 71:1332-41. 2010
  3. ncbi Defensive function of herbivore-induced plant volatile emissions in nature
    A Kessler
    Department of Molecular Ecology, Max-Planck-Institute for Chemical Ecology, Jena 07745, Germany
    Science 291:2141-4. 2001
  4. ncbi A candidate gene association study on muscat flavor in grapevine (Vitis vinifera L.)
    Francesco Emanuelli
    Research and Innovation Center, Fondazione Edmund Mach Istituto Agrario di San Michele all Adige, Via E, Mach 1, 38010 San Michele all Adige TN, Italy
    BMC Plant Biol 10:241. 2010
  5. ncbi Enhanced levels of the aroma and flavor compound S-linalool by metabolic engineering of the terpenoid pathway in tomato fruits
    E Lewinsohn
    Newe Ya ar Research Center, Agricultural Research Organization, Ramat Yishay 30095, Israel
    Plant Physiol 127:1256-65. 2001
  6. ncbi An integrated genomic, proteomic and biochemical analysis of (+)-3-carene biosynthesis in Sitka spruce (Picea sitchensis) genotypes that are resistant or susceptible to white pine weevil
    Dawn E Hall
    Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada
    Plant J 65:936-48. 2011
  7. ncbi Mechanisms of antibacterial action of three monoterpenes
    Domenico Trombetta
    Department Farmaco-Biologico, School of Pharmacy, University of Messina, Contrada Annunziata, 98168 Messina, Italy
    Antimicrob Agents Chemother 49:2474-8. 2005
  8. ncbi Differential timing of spider mite-induced direct and indirect defenses in tomato plants
    Merijn R Kant
    Institute for Biodiversity and Ecosystem Dynamics, Department of Plant Physiology, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    Plant Physiol 135:483-95. 2004
  9. ncbi Effects of oregano, carvacrol and thymol on Staphylococcus aureus and Staphylococcus epidermidis biofilms
    Antonia Nostro
    Dipartimento Farmaco Biologico, Facolta di Farmacia, Universita degli Studi di Messina, Villaggio Annunziata, 98168 Messina, Italy
    J Med Microbiol 56:519-23. 2007
  10. ncbi Genetic variation for sensitivity to a thyme monoterpene in associated plant species
    Catrine Grønberg Jensen
    Department of Biological Sciences, University of Aarhus, Ny Munkegade, Build 1540, 8000 Arhus C, Denmark
    Oecologia 162:1017-25. 2010

Research Grants

  1. Anti-Tumor Mechanism of the Monoterpens
    Hee Won Park; Fiscal Year: 2004
  2. SYNTHESES OF NATURAL PRODUCTS BY CYCLOADDITION REACTIONS
    Stephen Martin; Fiscal Year: 1990
  3. SPECIFICITY IN TERPENE AND STEROL BIOSYNTHESIS
    Robert Coates; Fiscal Year: 1992
  4. Monoterpenes in Cancer Prevention and Therapy
    Timothy Vincent; Fiscal Year: 2005
  5. Pancreatic Cancer Management by Novel Gene Therapy & Dietary Agents
    Paul Fisher; Fiscal Year: 2009
  6. Pancreatic Cancer Management by Novel Gene Therapy & Dietary Agents
    Paul B Fisher; Fiscal Year: 2010
  7. Anti-proliferative Effects of D-limonene against Prosta*
    Sanjay Gupta; Fiscal Year: 2005
  8. CRCNS-Multiple olfactory gamma oscillations: roles in sensation and attention
    Leslie Kay; Fiscal Year: 2007
  9. CRCNS: Computational and experimental analysis of noradrenergic function in early
    Christiane Linster; Fiscal Year: 2010
  10. CRCNS: Computational and experimental analysis of noradrenergic function in early
    Christiane Linster; Fiscal Year: 2007

Detail Information

Publications193 found, 100 shown here

  1. ncbi Asaricin, the main component of Ocotea opifera Mart. essential oil
    D Lorenzo
    Catedra de Farmacognosia y Productos Naturales, , General Montevideo, Uruguay
    Nat Prod Lett 15:163-70. 2001
    ..The structure has been established by a study of its mono- and bidimensional NMR spectra and mass spectrometry...
  2. ncbi The influence of Ceratocystis polonica inoculation and methyl jasmonate application on terpene chemistry of Norway spruce, Picea abies
    Tao Zhao
    Ecological Chemistry Group, Department of Chemistry, Royal Institute of Technology, SE 100 44 Stockholm, Sweden
    Phytochemistry 71:1332-41. 2010
    ..Thus, terpene composition in the stem bark may be related to resistance of Norway spruce against I. typographus and C. polonica...
  3. ncbi Defensive function of herbivore-induced plant volatile emissions in nature
    A Kessler
    Department of Molecular Ecology, Max-Planck-Institute for Chemical Ecology, Jena 07745, Germany
    Science 291:2141-4. 2001
    ..As a consequence, a plant could reduce the number of herbivores by more than 90% by releasing volatiles. These results confirm that indirect defenses can operate in nature...
  4. ncbi A candidate gene association study on muscat flavor in grapevine (Vitis vinifera L.)
    Francesco Emanuelli
    Research and Innovation Center, Fondazione Edmund Mach Istituto Agrario di San Michele all Adige, Via E, Mach 1, 38010 San Michele all Adige TN, Italy
    BMC Plant Biol 10:241. 2010
    ..has up to now been studied by evaluating monoterpenoid levels through QTL analysis. These studies have revealed co-localization of 1-deoxy-D-xylulose 5-phosphate synthase (VvDXS) with the major QTL positioned on chromosome 5...
  5. ncbi Enhanced levels of the aroma and flavor compound S-linalool by metabolic engineering of the terpenoid pathway in tomato fruits
    E Lewinsohn
    Newe Ya ar Research Center, Agricultural Research Organization, Ramat Yishay 30095, Israel
    Plant Physiol 127:1256-65. 2001
    ..Our studies indicate that it is possible to enhance the levels of monoterpenes in ripening fruits by metabolic engineering.
  6. ncbi An integrated genomic, proteomic and biochemical analysis of (+)-3-carene biosynthesis in Sitka spruce (Picea sitchensis) genotypes that are resistant or susceptible to white pine weevil
    Dawn E Hall
    Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada
    Plant J 65:936-48. 2011
    ..In conclusion, variation of the (+)-3-carene phenotype is controlled by copy number variation of PsTPS-3car genes, variation of gene and protein expression, and variation in catalytic efficiencies...
  7. ncbi Mechanisms of antibacterial action of three monoterpenes
    Domenico Trombetta
    Department Farmaco-Biologico, School of Pharmacy, University of Messina, Contrada Annunziata, 98168 Messina, Italy
    Antimicrob Agents Chemother 49:2474-8. 2005
    In the present paper, we report the antimicrobial efficacy of three monoterpenes [linalyl acetate, (+)menthol, and thymol] against the gram-positive bacterium Staphylococcus aureus and the gram-negative bacterium Escherichia coli...
  8. ncbi Differential timing of spider mite-induced direct and indirect defenses in tomato plants
    Merijn R Kant
    Institute for Biodiversity and Ecosystem Dynamics, Department of Plant Physiology, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    Plant Physiol 135:483-95. 2004
    ..Although transcriptional up-regulation of the enzymes involved in the biosynthesis of monoterpenes and diterpenes already occurred on day one, a significant increase in the emission of volatile terpenoids was ..
  9. ncbi Effects of oregano, carvacrol and thymol on Staphylococcus aureus and Staphylococcus epidermidis biofilms
    Antonia Nostro
    Dipartimento Farmaco Biologico, Facolta di Farmacia, Universita degli Studi di Messina, Villaggio Annunziata, 98168 Messina, Italy
    J Med Microbiol 56:519-23. 2007
    ..Subinhibitory concentrations of the oils attenuated biofilm formation of S. aureus and S. epidermidis strains on polystyrene microtitre plates...
  10. ncbi Genetic variation for sensitivity to a thyme monoterpene in associated plant species
    Catrine Grønberg Jensen
    Department of Biological Sciences, University of Aarhus, Ny Munkegade, Build 1540, 8000 Arhus C, Denmark
    Oecologia 162:1017-25. 2010
    ..The different responses within a species suggest that plant-plant interactions can evolve; this has implications for community dynamics and stability...
  11. ncbi Physical and chemical responses of Sitka spruce (Picea sitchensis) clones to colonization by Heterobasidion annosum as potential markers for relative host susceptibility
    Steve Woodward
    University of Aberdeen, School of Biological Sciences, Department of Plant and Soil Science, Cruickshank Building, St Machar Drive, Aberdeen AB24 3UU, U K
    Tree Physiol 27:1701-10. 2007
    ..The concentrations of the monoterpenes, except a few minor constituents, increased in the infected tissues. Wounding plus inoculation with H...
  12. ncbi Effect of monoterpenes on lipid oxidation in maize
    María P Zunino
    Instituto Multidisciplinario de Biología Vegetal, Catedra de Quimica Organica, Facultad de Ciencias Exactas Fisicas y Naturales, Universidad Nacional de Cordoba, Av Vélez Sarsfield 1600, 5016 Cordoba, Argentina
    Planta 219:303-9. 2004
    The monoterpenes 1,8-cineole, thymol, geraniol, menthol and camphor strongly inhibited the root growth of Zea mays L. seedlings...
  13. ncbi Interaction of four monoterpenes contained in essential oils with model membranes: implications for their antibacterial activity
    Mariateresa Cristani
    Department Farmaco Biologico, School of Pharmacy, University of Messina, Contrada Annunziata, 98168 Messina, Italy
    J Agric Food Chem 55:6300-8. 2007
    The present article reports the antimicrobial efficacy of four monoterpenes (thymol, carvacrol, p-cymene, and gamma-terpinene) against the Gram-positive bacterium Staphylococcus aureus and the Gram-negative bacterium Escherichia coli...
  14. ncbi DNA methyl transferase inhibiting halogenated monoterpenes from the Madagascar red marine alga Portieria hornemannii
    Eric H Andrianasolo
    College of Pharmacy, Oregon State University, Corvallis, OR 97331, USA
    J Nat Prod 69:576-9. 2006
    Three new halogenated monoterpenes, 2, 3, and 4, along with the known compounds halomon (1) and two analogues, 5 and 6, were isolated from the Madagascar red marine alga Portieria hornemannii...
  15. ncbi Glycosidic monoterpenes from Linaria capraria
    Armandodoriano Bianco
    Dipartimento di Chimica Università La Sapienza e Istituto di Chimica Biomolecolare del CNR, Piazzale Aldo Moro 5, 00185, Roma, Italy
    Nat Prod Res 18:241-6. 2004
    ..In addition a glucoside of an acyclic monoterpene, 4, was also isolated, which may be correlated to the other monoterpenic glycosides isolated from other species of Scrophulariaceae...
  16. ncbi Demonstration that menthofuran synthase of mint (Mentha) is a cytochrome P450 monooxygenase: cloning, functional expression, and characterization of the responsible gene
    C M Bertea
    Department of Plant Biology, University of Turin, Viale P.A. Mattioli 25, I-10125Turin, Italy
    Arch Biochem Biophys 390:279-86. 2001
    ..The availability of this gene permits transgenic manipulation of peppermint to improve the quality of the derived essential oil...
  17. ncbi Microtubules are an intracellular target of the plant terpene citral
    David Chaimovitsh
    Division of Aromatic Plants, Agricultural Research Organization, Newe Ya ar, PO Box 1021, Ramat Yishai 30095, Israel
    Plant J 61:399-408. 2010
    ..In addition, polymerization of microtubules in vitro was inhibited in the presence of citral. Taken together, our results suggest that citral is a potent, volatile, anti-microtubule compound...
  18. ncbi Electrophysiological and behavioral responses of Dendroctonus valens (Coleoptera: Curculionidae: Scolytinae) to four bark beetle pheromones
    Longwa Zhang
    State Key Laboratory of Integrated Management Agricultural Pest and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    Environ Entomol 38:472-7. 2009
    ..The possible roles of the pheromones in host and mate finding and selection are discussed...
  19. ncbi Comparative study on the antiviral activity of selected monoterpenes derived from essential oils
    Akram Astani
    Department of Virology, Hygiene Institute, University of Heidelberg, Heidelberg, Germany
    Phytother Res 24:673-9. 2010
    ..These essential oils were able to reduce viral infectivity by >96%, the monoterpenes inhibited HSV by about >80%...
  20. ncbi Isolation of halogenated monoterpenes from bioreactor-cultured microplantlets of the macrophytic red algae Ochtodes secundiramea and Portieria hornemannii
    Luis F Barahona
    CICY-Biotecnologia, Apartado Postal 87, 97310 Cordemex, Merida, Mexico
    J Nat Prod 66:743-51. 2003
    ..This study demonstrated that bioreactor tissue culture is a new venue for bioprospecting and production of natural compounds from marine macroalgae under a controlled environment...
  21. ncbi Induction of volatile terpene biosynthesis and diurnal emission by methyl jasmonate in foliage of Norway spruce
    Diane M Martin
    Biotechnology Laboratory, University of British Columbia, 6174 University Boulevard, Vancouver, British Columbia, Canada V6T 1Z3
    Plant Physiol 132:1586-99. 2003
    ..accumulation in needles without changes in terpene composition, much less than the 10- and 40-fold increases in monoterpenes and diterpenes, respectively, observed in wood tissue after MeJA treatment (D. Martin, D. Tholl, J...
  22. ncbi Organization of monoterpene biosynthesis in Mentha. Immunocytochemical localizations of geranyl diphosphate synthase, limonene-6-hydroxylase, isopiperitenol dehydrogenase, and pulegone reductase
    Glenn W Turner
    Institute of Biological Chemistry, Washington State University, Pullman, Washington 99164, USA
    Plant Physiol 136:4215-27. 2004
    ..We discuss this pathway compartmentalization in relation to possible mechanisms for the intracellular movement of monoterpene metabolites, and for monoterpene secretion into the extracellular essential oil storage cavity...
  23. ncbi Proton-transfer-reaction mass spectrometry as a new tool for real time analysis of root-secreted volatile organic compounds in Arabidopsis
    Marco Steeghs
    Aeronomy Laboratory, National Oceanic and Atmospheric Administration, Boulder, Colorado 80305, USA
    Plant Physiol 135:47-58. 2004
    ..The PTR-MS method may open the way for functional root VOC analysis that will complement genomic investigations in Arabidopsis...
  24. ncbi Inhibitory activity of 1,8-cineol (eucalyptol) on cytokine production in cultured human lymphocytes and monocytes
    Uwe R Juergens
    Department of Pneumology, Allergology and Sleep Medicine, Medical Outpatient Clinic, Bonn University Hospital, Wilhelmestrasse 35 37, Bonn D 53111, Germany
    Pulm Pharmacol Ther 17:281-7. 2004
    ....
  25. ncbi Monoterpenes from thyme (Thymus vulgaris) as potential mosquito repellents
    Byeoung-Soo Park
    School of Agricultural Biotechnology, Seoul National University, Suwon 441-744, Korea
    J Am Mosq Control Assoc 21:80-3. 2005
    Five monoterpenes (carvacrol, p-cymene, linalool, alpha-terpinene, and thymol) derived from the essential oil of thyme (Thymus vulgaris) were examined for their repellency against the mosquito Culex pipiens pallens...
  26. ncbi Gain and loss of fruit flavor compounds produced by wild and cultivated strawberry species
    Asaph Aharoni
    Plant Research International, 6700 AA, Wageningen, The Netherlands
    Plant Cell 16:3110-31. 2004
    ..the monoterpene linalool and the sesquiterpene nerolidol, fruit of wild strawberry species emit mainly olefinic monoterpenes and myrtenyl acetate, which are not found in the cultivated species...
  27. ncbi Impact of ozone on monoterpene emissions and evidence for an isoprene-like antioxidant action of monoterpenes emitted by Quercus ilex leaves
    Francesco Loreto
    CNR-Istituto di Biologia Agroambientale e Forestale, Monterotondo Scalo, Italy
    Tree Physiol 24:361-7. 2004
    Quercus ilex (L.) leaves emit monoterpenes, particularly alpha-pinene, beta-pinene and sabinene...
  28. ncbi A pharmacological profile of the aldehyde receptor repertoire in rat olfactory epithelium
    Ricardo C Araneda
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    J Physiol 555:743-56. 2004
    ..This large number of receptors for octanal suggests that, although the peripheral olfactory system is endowed with high sensitivity, discrimination among different compounds probably requires further central processing...
  29. ncbi Effects of monoterpenoids, acting alone or in pairs, on seed germination and subsequent seedling growth
    Despina Vokou
    Department of Ecology, School of Biology, Aristotle University, GR 54 006 Thessaloniki, Greece
    J Chem Ecol 29:2281-301. 2003
    ..The same holds true for the combined effect; its character cannot in general be predicted on the basis of individual compounds acting alone...
  30. ncbi Suppression of tumor necrosis factor-alpha-induced neutrophil adherence responses by essential oils
    Shigeru Abe
    Teikyo University Institute of Medical Mycology, 350 Otsuka, Hachioji, Tokyo 192-0395, Japan
    Mediators Inflamm 12:323-8. 2003
    ..CONCLUSION: Thus, some essential oils used as antiinflammatory remedies suppress neutrophil activation by TNF-alpha at a low concentration (0.0125-0.025 %) in vitro...
  31. ncbi Terpenoid metabolism in wild-type and transgenic Arabidopsis plants
    Asaph Aharoni
    Plant Research International, 6700 AA, Wageningen, The Netherlands
    Plant Cell 15:2866-84. 2003
    ..Most of the volatiles detected were monoterpenes and sesquiterpenes, which in contrast to other volatiles showed a diurnal emission pattern...
  32. ncbi Cross-adaptation between olfactory responses induced by two subgroups of odorant molecules
    Hiroko Takeuchi
    Department of Frontier Biosciences, Osaka University, Toyonaka, Osaka 560 8531, Japan
    J Gen Physiol 122:255-64. 2003
    ..The data will also provide evidence showing that olfactory response generation and adaptation are regulated by a uniform mechanism for a wide variety of odorants...
  33. ncbi Relaxant effect of essential oil of Melissa officinalis and citral on rat ileum contractions
    H Sadraei
    Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
    Fitoterapia 74:445-52. 2003
    ..28 microM) in a concentration-dependent manner with a IC(50) of approximately 20 ng/ml. Citral also had a concentration-dependent inhibitory effect on contraction of rat ileum with IC(50)s comparable to that of MOEO...
  34. ncbi Inhibition of citrus postharvest pathogens by vapor of citral and related compounds in culture
    Erminawati Wuryatmo
    School of Agriculture and Wine, The University of Adelaide, Waite Campus, PMB1, Glen Osmond, SA 5064, Australia
    J Agric Food Chem 51:2637-40. 2003
    ..R and S isomers of these three citral-related compounds generally had similar effects on the fungi tested...
  35. ncbi Patch testing with a new fragrance mix - reactivity to the individual constituents and chemical detection in relevant cosmetic products
    Peter J Frosch
    Department of Dermatology, Klinikum Dortmund gGmbH and University of Witten Herdecke, Germany
    Contact Dermatitis 52:216-25. 2005
    ..In conclusion, patients with a certain fragrance history and a negative reaction to FM I can be identified by FM II. Testing with individual constituents is positive in about 50% of cases reacting to either 14% or 28% FM II...
  36. ncbi A role for intra- and intercellular translocation in natural product biosynthesis
    Toni M Kutchan
    Leibniz Institut für Pflanzenbiochemie, Weinberg 3, 06120 Halle Saale, Germany
    Curr Opin Plant Biol 8:292-300. 2005
    ....
  37. ncbi Seasonal variations of monoterpene emissions from coniferous trees of different ages in Korea
    Jo Chun Kim
    Department of Environmental Engineering, Innovative Environmental Technology Centre, Konkuk University, Seoul 143 701, South Korea
    Chemosphere 59:1685-96. 2005
    ..obtusa. Higher monoterpene emission rates from each plant were found in spring and summer compared with autumn and winter emissions...
  38. ncbi Monoterpenes in the glandular trichomes of tomato are synthesized from a neryl diphosphate precursor rather than geranyl diphosphate
    Anthony L Schilmiller
    Department of Biochemistry and Molecular Biology, Research Technology Support Facility, Michigan State University, East Lansing, MI 48824 1319, USA
    Proc Natl Acad Sci U S A 106:10865-70. 2009
    ..that uses neryl diphosphate to produce beta-phellandrene as the major product as well as a variety of other monoterpenes. The profile of monoterpenes produced by PHS1 is identical with the monoterpenes found in type VI glands...
  39. ncbi Antiplasmodial halogenated monoterpenes from the marine red alga Plocamium cornutum
    Anthonia F Afolayan
    Division of Pharmaceutical Chemistry, Faculty of Pharmacy, Rhodes University, Artillery Road, Grahamstown 6140, South Africa
    Phytochemistry 70:597-600. 2009
    ..Two new and three known halogenated monoterpenes were isolated and their structures determined by standard spectroscopic techniques...
  40. ncbi The 1-deoxy-D: -xylulose 5-phosphate synthase gene co-localizes with a major QTL affecting monoterpene content in grapevine
    Juri Battilana
    Department of Genetics and Molecular Biology, IASMA Research Center, Fondazione Edmund Mach, 38010 San Michele all Adige, Italy
    Theor Appl Genet 118:653-69. 2009
    ..From a chemical point of view, it is strongly related to the accumulation of monoterpenes in berries. However, knowledge of the genetic mechanisms underlying its regulation is still limited...
  41. ncbi A grapevine (Vitis vinifera L.) deoxy-D: -xylulose synthase gene colocates with a major quantitative trait loci for terpenol content
    Eric Duchêne
    INRA, UMR 1131 Santé de la Vigne et Qualité du Vin, 28, rue de Herrlisheim, BP 20507, 68021, Colmar, France
    Theor Appl Genet 118:541-52. 2009
    ..The number of favourable alleles at this locus determined the level of terpenol synthesis. A second QTL, on LG 10, was found to determine the balance linalool versus geraniol and nerol in the Muscat self-progeny plants...
  42. ncbi Optimization of the transient transformation of Catharanthus roseus cells by particle bombardment and its application to the subcellular localization of hydroxymethylbutenyl 4-diphosphate synthase and geraniol 10-hydroxylase
    Grégory Guirimand
    Universite Francois Rabelais de Tours, EA 2106 Biomolécules et Biotechnologies Végétales, IFR 135 Imagerie Fonctionnelle, 37200, Tours, France
    Plant Cell Rep 28:1215-34. 2009
    ..Furthermore, we also demonstrated that G10H is an ER-anchored protein, consistent with the presence of a transmembrane helix at the G10H N-terminal end, which is both necessary and sufficient to drive the ER anchoring...
  43. ncbi Phase II trial of daily oral perillyl alcohol (NSC 641066) in treatment-refractory metastatic breast cancer
    Howard H Bailey
    University of Wisconsin Paul P Carbone Comprehensive Cancer Center, 600 Highland Avenue K4 6 CSC, Madison, WI 53792, USA
    Cancer Chemother Pharmacol 62:149-57. 2008
    ..We conducted a phase II multi-institutional study of oral POH administered four times daily in women with advanced treatment-refractory breast cancer...
  44. ncbi Composition, enantiomeric distribution, and antimicrobial activity of Tanacetum argenteum subsp. flabellifolium essential oil
    Nurhayat Tabanca
    USDA ARS NPURU, The University of Mississippi, University, MS 38677, USA
    J Pharm Biomed Anal 45:714-9. 2007
    ..Enantiomeric distribution of the monoterpenes alpha-pinene and camphor was determined on a fused silica Lipodex E capillary column using a multidimensional ..
  45. ncbi Spatial distribution and hormonal regulation of gene products from methyl erythritol phosphate and monoterpene-secoiridoid pathways in Catharanthus roseus
    Audrey Oudin
    EA 2106 Biomolécules et Biotechnologies Végétales, UFR des Sciences Pharmaceutiques, Universite Francois Rabelais de Tours, Tours, France
    Plant Mol Biol 65:13-30. 2007
    ..roseus cells, our results support that intercellular translocation likely plays an important role during monoterpene-secoiridoid assembly...
  46. ncbi Effects of 1,8-cineole on the dynamics of lipids and proteins of stratum corneum
    Jorge Luiz Vieira Dos Anjos
    Instituto de Fisica, Universidade Federal de Goias, Goiânia 74001 970, GO, Brazil
    Int J Pharm 345:81-7. 2007
    ..Instead, this terpene only increases the solvent's ability to 'dissolve' and mobilize the nitroxide side chain, which is in agreement with its low irritation response...
  47. ncbi The role of genetic and chemical variation of Pinus sylvestris seedlings in influencing slug herbivory
    Julianne M O'Reilly-Wapstra
    School of Plant Science and CRC for Forestry, University of Tasmania, Private Bag 55, Hobart, TAS 7001, Australia
    Oecologia 152:82-91. 2007
    ..We also investigated the feeding responses of A. ater to artificial diets laced with two monoterpenes, Delta(3)-carene and alpha-pinene...
  48. ncbi Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels
    Haoxing Xu
    Howard Hughes Medical Institute, Harvard Medical School, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Neurosci 9:628-35. 2006
    ..Our results support a role for temperature-sensitive TRP channels in chemesthesis in oral and nasal epithelium and suggest that TRPV3 may be a molecular target of plant-derived skin sensitizers...
  49. ncbi Dynamics of the enhanced emissions of monoterpenes and methyl salicylate, and decreased uptake of formaldehyde, by Quercus ilex leaves after application of jasmonic acid
    Iolanda Filella
    Unitat Ecofisiologia CSIC CEAB CREAF, Center for Ecological Research and Forestry Applications CREAF, Universitat Autonoma de Barcelona, 08193 Bellaterra Barcelona, Spain
    New Phytol 169:135-44. 2006
    ..Jasmonic acid-mediated increases in monoterpene and MeSa emissions might have a protective role when confronting biotic and abiotic stresses...
  50. ncbi Epidermis is a pivotal site of at least four secondary metabolic pathways in Catharanthus roseus aerial organs
    Samira Mahroug
    , , Parc de Grandmont, 37200 Tours, France
    Planta 223:1191-200. 2006
    ..g. flavonoïds, indoles, secoiridoid-monoterpenes and MIAs). These results, and data showing co-accumulation of flavonoids and alkaloids in single cells of C...
  51. ncbi Effect of physicochemical properties of cyclic terpenes on their ex vivo skin absorption and elimination kinetics
    Krzysztof Cal
    Medical University of Gdansk, Department of Pharmaceutical Technology, Hallera 107, 80 416 Gdansk, Poland
    J Dermatol Sci 41:137-42. 2006
    ....
  52. ncbi Response of Plutella xylostella and its parasitoid Cotesia plutellae to volatile compounds
    Mohamed A Ibrahim
    Department of Ecology and Environmental Science, University of Kuopio, Kuopio, Finland
    J Chem Ecol 31:1969-84. 2005
    ..The attractive effect of limonene and MeJA predicts that these two compounds can be used in sustainable plant protection strategies in organic farming...
  53. ncbi CaaX-prenyltransferases are essential for expression of genes involvedin the early stages of monoterpenoid biosynthetic pathway in Catharanthus roseus cells
    Vincent Courdavault
    Biomolecules et Biotechnologies Vegetales, Labaratoire de Physiologie Vegetale, UFR Science et Techniques, Universite Francois-Rabelais de Tours, EA2106, 37200, Parc de Grandmont, Tours, France
    Plant Mol Biol 57:855-70. 2005
    ..We conclude that protein targets for both PFT and PGGT-I are required for the expression of ESMB genes and monoterpenoid biosynthesis in C. roseus, this represents a non previously described role for protein prenyltransferase in plants...
  54. ncbi Olfactory receptor neurons in two Heliothine moth species responding selectively to aliphatic green leaf volatiles, aromatic compounds, monoterpenes and sesquiterpenes of plant origin
    T Røstelien
    Neuroscience Unit, Department of Biology, Norwegian University of Science and Technology, NO 7489 Trondheim, Norway
    Chem Senses 30:443-61. 2005
    ..The specificity as well as the co-localization of particular neuron types so far recorded in both species showed similarities of the olfactory systems receiving plant odour information in these two species of heliothine moths...
  55. ncbi Real-time monitoring of herbivore induced volatile emissions in the field
    Andrea Schaub
    Ionicon Analytik GmbH, Technikerstrasse 21a, 6020 Innsbruck, Austria
    Physiol Plant 138:123-33. 2010
    ..However, there was a clear effect on SQT measurements. Elucidation of emission patterns in real-time is dependent upon the dynamics of cuvettes at different temperatures...
  56. ncbi Anti-inflammatory activity of 1.8-cineol (eucalyptol) in bronchial asthma: a double-blind placebo-controlled trial
    U R Juergens
    Department of Pneumology, Medical Outpatient Clinic, Bonn University Hospital, Germany
    Respir Med 97:250-6. 2003
    ..This is the first evidence suggesting an anti-inflammatory activity of the monoterpene 1.8-cineol in asthma and a new rational for its use as mucolytic agent in upper and lower airway diseases...
  57. ncbi Constituents of aromatic plants: eucalyptol
    M De Vincenzi
    Department of Metabolism and Pathological Biochemistry ISS, Rome, Italy
    Fitoterapia 73:269-75. 2002
    ..Following the accidental exposure of human beings, death was reported in two cases after ingestion of 3.5-5 ml of essential eucalyptus oil, but a number of recoveries have also been described for much higher amounts of oil...
  58. ncbi Bornyl diphosphate synthase: structure and strategy for carbocation manipulation by a terpenoid cyclase
    Douglas A Whittington
    Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia 19104-6323, USA
    Proc Natl Acad Sci U S A 99:15375-80. 2002
    ..Structures of complexes with aza analogues of substrate and carbocation intermediates, as well as complexes with pyrophosphate and bornyl diphosphate, provide "snapshots" of the terpene cyclization cascade...
  59. ncbi Response properties of isolated mouse olfactory receptor cells
    J Reisert
    Physiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    J Physiol 530:113-22. 2001
    ..Second, the response to the second stimulus only recovered to 55% of its original magnitude, demonstrating the involvement of Na+-Ca2+ exchange in the recovery of sensitivity in mouse olfactory receptor cells following stimulation...
  60. ncbi Differential incorporation of 1-deoxy-D-xylulose into (3S)-linalool and geraniol in grape berry exocarp and mesocarp
    Fang Luan
    , Biozentrum, , Marie-Curie-Strasse 9, D-60439, Frankfurt, Germany
    Phytochemistry 60:451-9. 2002
    ..The results demonstrate that grape berries exhibit an autonomic monoterpene biosynthesis via the novel DOXP/MEP route throughout the ripening process...
  61. ncbi Biosynthesis and emission of terpenoid volatiles from Arabidopsis flowers
    Feng Chen
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Plant Cell 15:481-94. 2003
    ..Here, we show that Arabidopsis flowers emit both monoterpenes and sesquiterpenes, potential olfactory cues for pollinating insects...
  62. ncbi In vivo studies on the metabolism of the monoterpenes S-(+)- and R-(-)-carvone in humans using the metabolism of ingestion-correlated amounts (MICA) approach
    W Engel
    Deutsche Forschungsanstalt fur Lebensmittelchemie, Lichtenbergstrasse 4, D 85748 Garching, Germany
    J Agric Food Chem 49:4069-75. 2001
    ..No differences in metabolism between S-(+)- and R-(-)-carvone were detected...
  63. ncbi Monoterpene regulation of Ras and Ras-related protein expression
    Sarah A Holstein
    Departments of Pharmacology, University of Iowa, Iowa City, IA 52242, USA
    J Lipid Res 44:1209-15. 2003
    b>Monoterpenes, derived primarily from plants, are products of the isoprenoid biosynthetic pathway and function as chemical messengers with diverse functions. The biochemical bases for these activities are largely undefined...
  64. ncbi Repellent activities of essential oils and monoterpenes against Culex pipiens pallens
    Won-Sik Choi
    Department of Life Science, Soonchunhyang University, Asan, Chungnam 337-745, Republic of Korea
    J Am Mosq Control Assoc 18:348-51. 2002
    ..With gas chromatography-mass spectrometry analysis, thyme essential oil was a rich source of 5 monoterpenes, including in descending order thymol, p-cymene, carvacrol, linalool, and alpha-terpinene...
  65. ncbi Antiinflammatory effects of euclyptol (1.8-cineole) in bronchial asthma: inhibition of arachidonic acid metabolism in human blood monocytes ex vivo
    U R Juergens
    Abteilung Pneumologie, Medizinische Universitäts Poliklinik Bonn, Wilhelmstrasse 35 37, D 53111 Bonn, Germany
    Eur J Med Res 3:407-12. 1998
    b>Monoterpenes are prescribed to treat chronic obstructive airway disorders mainly because of their familiar secretolytic properties. The aim of this study was to investigate the effect of 1...
  66. ncbi Bioactive constituents of Chinese natural medicines. V. Radical scavenging effect of Moutan Cortex. (1): Absolute stereostructures of two monoterpenes, paeonisuffrone and paeonisuffral
    M Yoshikawa
    Kyoto Pharmaceutical University, Japan
    Chem Pharm Bull (Tokyo) 48:1327-31. 2000
    ..Two monoterpenes called paeonisuffrone and paeonisuffral were isolated from the ethyl acetate-soluble fraction...
  67. ncbi Anticonvulsant properties of linalool in glutamate-related seizure models
    E Elisabetsky
    Departamento de Farmacologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Phytomedicine 6:107-13. 1999
    ..Linalool partially inhibited and significantly delayed the behavioral expression of PTZ-kindling, but did not modify the PTZ-kindling-induced increase in L-[3H]glutamate binding...
  68. ncbi Effects of perillyl alcohol in glial C6 cell line in vitro and anti-metastatic activity in chorioallantoic membrane model
    Ilana Teruszkin Balassiano
    Instituto de Biofisica Carlos Chagas Filho, Laboratorio de Controle da Expressao Genica, Universidade Federal do Rio de Janeiro, Centro de Ciencias da Saude, Rio de Janeiro, Brazil
    Int J Mol Med 10:785-8. 2002
    ..3 to 0.003% POH for 2 h, prior to its inoculation in chick embryo chorioallantoic membrane model. This phenomenon shows the possible role of POH as an in vivo anti-metastatic drug...
  69. ncbi The water-soluble components of the essential oil of Melaleuca alternifolia (tea tree oil) suppress the production of superoxide by human monocytes, but not neutrophils, activated in vitro
    C Brand
    Department of Microbiology and Infectious Diseases, School of Medicine, Flinders University, Adelaide, Australia
    Inflamm Res 50:213-9. 2001
    ..CONCLUSION: Tea tree oil components suppress the production of superoxide by monocytes, but not neutrophils, suggesting the potential for selective regulation of cell types by these components during inflammation...
  70. ncbi [Allelopathy and chemical constituents of Ligularia virgaurea volatile]
    Ruijun Ma
    College of Life Sciences, Northwest Normal University, Lanzhou, China
    Ying Yong Sheng Tai Xue Bao 16:1826-9. 2005
    ..virgaurea released allelochemicals. The allelopathy of the volatile may play an important role in enhancing the competitive ability of the species, and be one of reasons of grassland degeneration...
  71. ncbi Gas chromatographic-mass spectrometric analysis of essential oils from Pimpinella aurea, Pimpinella corymbosa, Pimpinella peregrina and Pimpinella puberula gathered from Eastern and Southern Turkey
    Nurhayat Tabanca
    USDA-ARS-NPURU, The University of Mississippi, University, MS 38677, USA
    J Chromatogr A 1097:192-8. 2005
    ..8-42.8%). The other fractions were dominated by different sesquiterpene compounds although in three of them, P. aurea stem and leaves, P. puberula fruits and P. puberula stems and leaves, monoterpene constituents also appear as main ones...
  72. ncbi Linalool from Lippia alba: study of the reproducibility of the essential oil profile and the enantiomeric purity
    Antonio C Siani
    Laboratório de Química de Produtos Naturais, Instituto de Tecnologia em Fármacos, Fundacao Oswaldo Cruz, Rua Sizenando Nabuco 100, Manguinhos, Rio de Janeiro, RJ, Brazil, 21041 250
    J Agric Food Chem 50:3518-21. 2002
    ..Purification of linalool to a content close to 100% was effected by vacuum distillation of the crude oil. Chiral analysis showed exclusively the presence of S-linalool in all the crude oils and in the distilled samples...
  73. ncbi Main agronomic-productive characteristics of two ecotypes of Rosmarinus officinalis L. and chemical composition of their essential oils
    Guido Flamini
    Dipartimento di Chimica Bioorganica e Biofarmacia and Agronomy Department, Via S. Michele degli Scalzi 2, 56124 Pisa University, Italy
    J Agric Food Chem 50:3512-7. 2002
    ..The Cevoli ecotype could be classifited as an alpha-pinene chemotype, whereas Lunigiana is a 1,8-cineole chemotype...
  74. ncbi Effect of different locations on the chemical composition of essential oils of laurel (Laurus nobilis L.) leaves growing wild in Turkey
    Musa Ozcan
    Department of Food Engineering, Faculty of Agriculture, University of Selcuk, Konya, Turkey
    J Med Food 8:408-11. 2005
    ..As a result, the 1,8-cineole content of these oils was significantly higher than those of other constituents of L. nobilis. Laurel is usually considered as the natural source of this compound, used in the flavor and fragrance industry...
  75. ncbi Eucalyptus camaldulensis: volatiles from immature flowers and high production of 1,8-cineole and beta-pinene by in vitro cultures
    A Giamakis
    Division of Botany, Department of Biology, University of Athens, 157 71, Athens, Greece
    Phytochemistry 58:351-5. 2001
    ..only of alkanes, alkenes and alcohols, while that of calli developed from immature flowers consisted mainly of monoterpenes (92.08-96.56%)...
  76. ncbi [Studies on the chemical constituents of the essential oil of Artemisia dracunculus]
    Yan Zhang
    Department of Biology and Chemistry, Kashi Normal College, Kashi 844007, China
    Zhongguo Zhong Yao Za Zhi 30:594-6. 2005
    ..96%), 1-methoxy-4-(2-Propenyl)-benzene (8.57%), limonene (6.33%), 1R-alpha-pinene (3.40%), etc. CONCLUSION: The study provided solid and scientific proof for the further exploitation and utilization of A. dracunculus...
  77. ncbi Chemical composition and antibacterial activity of the essential oil and the gum of Pistacia lentiscus Var. chia
    Christina Koutsoudaki
    Department of Chemistry and Department of Biological Sciences, University of Warwick, Warwick, Coventry CV4 7AL, United Kingdom
    J Agric Food Chem 53:7681-5. 2005
    ..Mastic gum was also examined, but it proved to be more difficult to handle compared to the essential oil...
  78. ncbi Use of novel compounds for pest control: insecticidal and acaricidal activity of essential oil components from heartwood of Alaska yellow cedar
    Nicholas A Panella
    Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Fort Collins, CO 80522, USA
    J Med Entomol 42:352-8. 2005
    ..adults. Four of the compounds from the essential oil have been identified as monoterpenes, five as eremophilane sesquiterpenes, five as eremophilane sesquiterpene derivatives from valencene and ..
  79. ncbi Phytochemical induction by herbivores could affect quality of essential oils from aromatic plants
    Graciela R Valladares
    Centro de Investigaciones Entomologicas, FCEFYN, Universidad Nacional de Cordoba, Cordoba, Argentina
    J Agric Food Chem 50:4059-61. 2002
    ..leaves, as well as leaves from stems with and without galls, revealed changes in concentrations of the two main monoterpenes. A decrease in pulegone concentration was associated with both types of insect damage, whereas menthone ..
  80. ncbi Acaricidal activity of pine essential oils and their main components against Tyrophagus putrescentiae, a stored food mite
    F Macchioni
    Dipartimento di Chimica Biorganica e Biofarmacia, , Viale delle Piagge 2, Pisa 56124, Italy
    J Agric Food Chem 50:4586-8. 2002
    ..pinea oil and its two constituents 1,8-cineole and limonene were the most effective compounds, showing 100% acaricidal activity at 8 microL; 1,8-cineole showed the same activity at 6 microL...
  81. ncbi Characterization of essential oils from lamiaceae species by fourier transform Raman spectroscopy
    Dimitra J Daferera
    Laboratory of General Chemistry, Agricultural University of Athens, 75 Iera Odos, Greece
    J Agric Food Chem 50:5503-7. 2002
    ..The results demonstrate that certain Raman intensities can be correlated to specific terpenes and therefore FT-Raman can discriminate between the essential oils of which main components belong to different classes of compounds...
  82. ncbi Chemical composition of volatiles in Sardinian myrtle (Myrtus communis L.) alcoholic extracts and essential oils
    Carlo I G Tuberoso
    Dipartimento di Tossicologia, Universita di Cagliari, Via Ospedale 72, 09124 Cagliari, Italy
    J Agric Food Chem 54:1420-6. 2006
    ..The major compounds in the essential oils were alpha-pinene (30.0 and 28.5%), 1,8-cineole (28.8 and 15.3%), and limonene (17.5 and 24.1%) in leaves and berries, respectively, and were characterized by the lack of myrtenyl acetate...
  83. ncbi Stratum corneum absorption and retention of linalool and terpinen-4-ol applied as gel or oily solution in humans
    Krzysztof Cal
    J Dermatol Sci 42:265-7. 2006
  84. ncbi Insecticidal properties of essential plant oils against the mosquito Culex pipiens molestus (Diptera: Culicidae)
    Abdallah F Traboulsi
    Faculty of Agricultural Sciences, Lebanese University, Beirut, Lebanon
    Pest Manag Sci 58:491-5. 2002
    ..Thymol, carvacrol, (1R)-(+)-alpha-pinene and (1S)-(-)-alpha-pinene were the most toxic (LC50 = 36-49 mg litre-1), while menthone, 1,8-cineole, linalool and terpineol (LC50 = 156-194 mg litre-1) were less toxic...
  85. ncbi A comparison of volatile components from the peel of Ohshima no. 1 with its parent cultivars
    Yoshihiko Akakabe
    Department of Biological Chemistry, Faculty of Agriculture, Yamaguchi University, Yoshida, Yamaguchi, Japan
    Biosci Biotechnol Biochem 72:1969-72. 2008
    ..By PCA analysis, it was found that the odor quality of Ohshima no. 1 was very different from those of the parent cultivars...
  86. ncbi Essential oil composition of Teucrium scordium L
    Katayoun Morteza Semnani
    Department of Medicinal Chemistry Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Acta Pharm 57:499-504. 2007
    ..scordium. The major constituents of the oil were beta-caryophyllene (22.8%), (E)-beta-farnesene (10.4%), caryophyllene oxide (8.6%), 1,8-cineole (6.1%) and beta-eudesmol (5.1%)...
  87. ncbi Gas chromatography/mass spectrometry analysis of Laurus nobilis essential oil composition of northern Cyprus
    Hasan Yalçin
    Food Technology Department, Vocational High School of Technical Science, Selcuk University, Konya, Turkey
    J Med Food 10:715-9. 2007
    ..Of the 81 compounds representing 98.74% of total oil, monocyclic monoterpenes such as 1,8-cineole (58.59%), alpha-terpinyl acetate (8.82%), and terpinene-4-ol (4...
  88. ncbi Comparative analysis of essential oil components in Pericarpium Citri Reticulatae Viride and Pericarpium Citri Reticulatae by GC-MS combined with chemometric resolution method
    Yamin Wang
    Research Center of Chinese Traditional and Herbal Drug Modernization, College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China
    J Pharm Biomed Anal 46:66-74. 2008
    ..The results obtained may be helpful to find out the possibly bioactive compounds of PCRV and PCR...
  89. ncbi Variation of the chemical profile and antioxidant behavior of Rosmarinus officinalis L. and Salvia fruticosa Miller grown in Greece
    Vassiliki Papageorgiou
    Agricultural University of Athens, Food Science and Technology Dept, Iera Odos 75, Athens, Greece, 118 55
    J Agric Food Chem 56:7254-64. 2008
    ..The antioxidant activity was correlated with the amount of total phenolic content...
  90. ncbi Composition and enantiomeric analysis of the essential oil of the fruits and the leaves of Pistacia vera from Greece
    Anastasia Tsokou
    Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece
    Molecules 12:1233-9. 2007
    ..Thirty three compounds were identified in the essential oil of the leaves and the major components were found to be alpha-pinene (30.0%), terpinolene (17.6%) and bornyl acetate (11.3%)...
  91. ncbi Changes in essential oil during enzyme-assisted ensiling of lemongrass (Cymbopogon citratus Stapf.) and lemon eucalyptus (Eucalyptus citriodora Hook)
    N Dudai
    Division of Aromatic Plants, Agricultural Research Organization, Newe Ya'ar Research Center, P.O. Box 1021, Ramat Yishay, Israel
    J Agric Food Chem 49:2262-6. 2001
    ..Citronellal, which was the major component of the essential oil in the fresh eucalyptus leaves, decreased, whereas isopulegol and 3,8-terpinolhydrate increased during ensiling...
  92. ncbi Volatile components of peel and leaf oils of lemon and lime species
    Marie-Laure Lota
    , Equipe Chimie et Biomasse, UMR CNRS 6134, Route des Sanguinaires, 20000 Ajaccio, France
    J Agric Food Chem 50:796-805. 2002
    ..Four others were identified for lime leaf oils: beta-pinene/limonene; limonene/geranial/neral; limonene/linalool/citronellal; and limonene/sabinene/citronellal/linalool. These results were interpreted using principal component analysis...
  93. ncbi The survival of three strains of Arcobacter butzleri in the presence of lemon, orange and bergamot essential oils and their components in vitro and on food
    K Fisher
    School of Health, The University of Northampton, Northampton, UK
    Lett Appl Microbiol 44:495-9. 2007
    ..To test the effect of oils and vapours of lemon, sweet orange and bergamot and their components against three Arcobacter butzleri strains...
  94. ncbi The influence of essential oils on human attention. I: alertness
    J Ilmberger
    Department of Physical Medicine and Rehabilitation, Klinikum Grosshadern, , Marchioninistrasse 15, D-81377 Munich, Germany
    Chem Senses 26:239-45. 2001
    ....
  95. ncbi [Analysis of the essential oils from Amomun kravak Pierre ex Gagnep by GC-MS]
    Hui Qin Wu
    Guangdong Key Laboratory of Chemical Emergency Test, China National Analytical Center, Guangzhou 510070, China
    Zhong Yao Cai 29:788-92. 2006
    ..To establish the fingerprint chromatogram of Amomun kravak Pierre ex Gagnep...
  96. ncbi Phylogenetic fragrance patterns in Nicotiana sections Alatae and Suaveolentes
    Robert A Raguso
    Department of Biological Sciences, Coker Life Sciences Building, University of South Carolina, Columbia, SC 29208, USA
    Phytochemistry 67:1931-42. 2006
    ..Newly discovered taxa in Alatae, like their relatives, emit large amounts of 1,8-cineole and smaller amounts of monoterpenes on a nocturnal rhythm, constituting a chemical synapomorphy for this lineage...
  97. ncbi Characterization of steam volatiles in the essential oil of black currant buds and the antioxidant properties of different bud extracts
    Asta Dvaranauskaite
    Kaunas University of Technology, Radvilenu pl 19, LT 50254, Kaunas, Lithuania
    J Agric Food Chem 56:3279-86. 2008
    ..The total amount of phenolic compounds expressed in gallic acid equivalents in FDWF varied in the range of 132-192 mg/g; in SDWF, 140-209 mg/g; in AE, 49-107 mg/g; and in ME extracts, 111-180 mg/g...
  98. ncbi Influence of lipid fraction, emulsifier fraction, and mean particle diameter of oil-in-water emulsions on the release of 20 aroma compounds
    Saskia M van Ruth
    Department of Food Science, Food Technology and Nutrition, University College Cork, Western Road, Cork, Ireland
    J Agric Food Chem 50:2365-71. 2002
    ..Lipid fraction, emulsifier fraction, and particle diameter affected the kinetic component of aroma release, which could partially be attributed to changes in viscosity...
  99. ncbi Ability of essential oil candles to repel biting insects in high and low biting pressure environments
    Gunter C Muller
    Department of Parasitology, Kuvin Centre for the Study of Infectious and Tropical Diseases, The Hebrew University, Hadassah Medical School, 91120 Jerusalem, Israel
    J Am Mosq Control Assoc 24:154-60. 2008
    ..0 m. In the low biting pressure environment, geraniol reduced the mosquito pressure by an average of 62%. No sand flies were present at this site...
  100. ncbi Characterization of volatiles in Costa Rican guava [Psidium friedrichsthalianum (Berg) Niedenzu] fruit
    Jorge A Pino
    Food Industry Research Institute, Carretera del Guatao km 3 1/2, La Habana 19200, Cuba
    J Agric Food Chem 50:6023-6. 2002
    ..The amounts of aliphatic esters and terpenic compounds were thought to contribute to the unique flavor of this fruit...
  101. ncbi Composition and antifungal activity on soil-borne pathogens of the essential oil of Salvia sclarea from Greece
    Danae Pitarokili
    Department of Pharmacognosy, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, 157 71 Athens, Greece
    J Agric Food Chem 50:6688-91. 2002
    ..45-12.1%), and alpha-terpineol (5.08-7.56%) were the main components. The antifungal activity of the oil of one locality and of the main components, linalyl acetate and linalool, was evaluated in vitro against three soil-borne pathogens...

Research Grants89

  1. Anti-Tumor Mechanism of the Monoterpens
    Hee Won Park; Fiscal Year: 2004
    Limonene and perillyl alcohol are monoterpenes that are dietary components as well as food flavoring agents and scent additives. Limonene is abundant in orange peel oil, and perillyl alcohol in cherry and spearmint...
  2. SYNTHESES OF NATURAL PRODUCTS BY CYCLOADDITION REACTIONS
    Stephen Martin; Fiscal Year: 1990
    ..condylocarpine, and strychnine; the Ajmaline and Sarpagine alkaloids quebrachidine and akuammidine; the iridoid monoterpenes loganin and secologanin, which are important biosynthetic precursors of the indole alkaloids and the iridoids, ..
  3. SPECIFICITY IN TERPENE AND STEROL BIOSYNTHESIS
    Robert Coates; Fiscal Year: 1992
    ..6. Determination of the stereochemistry and isotope effects of eliminations that terminate enzymatic cyclizations producing enantiomeric monoterpenes.
  4. Monoterpenes in Cancer Prevention and Therapy
    Timothy Vincent; Fiscal Year: 2005
    b>Monoterpenes are a class of phytochemicals that possess cancer preventative and therapeutic properties. The prototypical monoterpene Perillyl alcohol (POH) is currently in clinical trials for the treatment of cancers...
  5. Pancreatic Cancer Management by Novel Gene Therapy & Dietary Agents
    Paul Fisher; Fiscal Year: 2009
    ..Dietary monoterpenes, such as perillyl alcohol (POH) also exhibit anti- tumor properties...
  6. Pancreatic Cancer Management by Novel Gene Therapy & Dietary Agents
    Paul B Fisher; Fiscal Year: 2010
    ..Dietary monoterpenes, such as perillyl alcohol (POH) also exhibit anti- tumor properties...
  7. Anti-proliferative Effects of D-limonene against Prosta*
    Sanjay Gupta; Fiscal Year: 2005
    ..Recent studies have shown that monoterpenes possess anticancer properties and suggest that these compounds represent a new class of agents for cancer ..
  8. CRCNS-Multiple olfactory gamma oscillations: roles in sensation and attention
    Leslie Kay; Fiscal Year: 2007
    ..We anticipate that understanding how olfactory deficits arise from changes in the limbic system associated with many of these disorders, will help us to understand the mechanisms that produce cognitive malfunctioning. ..
  9. CRCNS: Computational and experimental analysis of noradrenergic function in early
    Christiane Linster; Fiscal Year: 2010
    ..Neuromodulation is involved in many major degenerative diseases of brain function;a better understanding of the functions of these systems will have a high impact on public health. ..
  10. CRCNS: Computational and experimental analysis of noradrenergic function in early
    Christiane Linster; Fiscal Year: 2007
    ..Neuromodulation is involved in many major degenerative diseases of brain function; a better understanding of the functions of these systems will have a high impact on public health. ..
  11. Cholinergic modulation of olfactory processing
    Christiane Linster; Fiscal Year: 2007
    ..These data should provide important insights into how neurodegenerative diseases affect olfactory sensation. ..
  12. OLFACTORY CODING
    Burton Slotnick; Fiscal Year: 2003
    ..Behavior tasks will use precision olfactometry. Anterograde transport of horseradish peroxidase will be used to assess connections between the olfactory epithelium and olfactory bulb in experimental rats. ..
  13. OLFACTORY FUNCTION IN GENE-TARGETED MICE
    Burton Slotnick; Fiscal Year: 2002
    ..A final report of these studies will incorporate a detailed description of apparatus, methods protocol and files of raw data and summary statistics presented in database and spreadsheet format. ..
  14. Cholinergic modulation of odor responses
    Christiane Linster; Fiscal Year: 2003
    ....
  15. CRCNS: Computational and experimental analysis of noradrenergic function in early
    Christiane Linster; Fiscal Year: 2009
    ..Neuromodulation is involved in many major degenerative diseases of brain function; a better understanding of the functions of these systems will have a high impact on public health. ..
  16. Oxidative Coupling in Natural Product Synthesis
    Phil Baran; Fiscal Year: 2007
    ....
  17. Limits of Multi-Tetrode Intracortical Microstimulation
    MARK LEHMKUHLE; Fiscal Year: 2006
    ..This work is of potentially great relevance in the development and design of an electrical brain-machine interface capable of stimulating auditory cortex in such a manner as to artificially evoke auditory perceptions. ..
  18. Anti-Trypanosomal Agents from a Neotropical Cloudforest
    WILLIAM SETZER; Fiscal Year: 2004
    ..The long-term benefit of this research project is the development of new medicines to treat patients with Chagas disease. ..
  19. Nucleotide selectivity and drug resistance by HIV reverse transcriptase
    KENNETH ALLEN JOHNSON; Fiscal Year: 2010
    ....
  20. TRP Channel-Dependent Regulation of Arterial Tone
    Scott Earley; Fiscal Year: 2010
    ..The ultimate goal of this project is to improve human health by stimulating the development of new pharmaceuticals that act through TRPM4 to control and prevent cardiovascular-related diseases. ..
  21. Mechanism of mitochondrial DNA replication
    KENNETH ALLEN JOHNSON; Fiscal Year: 2010
    ....
  22. TRP Channel-Dependent Regulation of Arterial Tone
    Scott Earley; Fiscal Year: 2009
    ..The ultimate goal of this project is to improve human health by stimulating the development of new pharmaceuticals that act through TRPM4 to control and prevent cardiovascular-related diseases. ..
  23. TRPM4 Channels in the Control of Cerebral Artery Tone
    Scott Earley; Fiscal Year: 2005
    ..It is anticipated that these studies will generate significant new information regarding the role of mechanosensitive cation channels in the regulation of VSM membrane potential and the regulation of cerebral blood flow. ..
  24. MECHANISM AND FIDELITY OF DNA REPLICATION
    Kenneth Johnson; Fiscal Year: 2006
    ..abstract_text> ..
  25. Elementary Steps in DNA Polymerization
    Kenneth Johnson; Fiscal Year: 2007
    ..abstract_text> ..
  26. MECHANISM AND FIDELITY OF DNA REPLICATION
    Kenneth Johnson; Fiscal Year: 2003
    ..The mechanism and fidelity of the mitochondrial polymerase will be established by kinetic measurements. ..
  27. KINETIC ANALYSIS OF MICROTUBULE-DEPENDENT ATPASES
    Kenneth Johnson; Fiscal Year: 2003
    ..The combination of approaches outlined here will provide rigorous and direct information to define the structural and mechanistic basis for force production by kinesin. ..