phorbol esters

Summary

Summary: Tumor-promoting compounds obtained from CROTON OIL (Croton tiglium). Some of these are used in cell biological experiments as activators of protein kinase C.

Top Publications

  1. ncbi Prostratin induces HIV activation and downregulates HIV receptors in peripheral blood lymphocytes
    Joaquín Rullas
    AIDS Immunopathogenesis Unit, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Madrid, Spain
    Antivir Ther 9:545-54. 2004
  2. pmc Effects of prostratin on T-cell activation and human immunodeficiency virus latency
    Yael D Korin
    Department of Medicine, UCLA School of Medicine, and UCLA AIDS Institute, 90095 1678, USA
    J Virol 76:8118-23. 2002
  3. ncbi Prostratin: activation of latent HIV-1 expression suggests a potential inductive adjuvant therapy for HAART
    J Kulkosky
    Dorrance H Hamilton Laboratories, Center for Human Virology, Division of Infectious Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Blood 98:3006-15. 2001
  4. ncbi Protein kinase C and other diacylglycerol effectors in cancer
    Erin M Griner
    Department of Pharmacology and Institute for Translational Medicine and Therapeutics ITMAT, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
    Nat Rev Cancer 7:281-94. 2007
  5. ncbi Phorbol esters: structure, biological activity, and toxicity in animals
    Gunjan Goel
    Institute for Animal Production in the Tropics and Subtropics, University of Hohenheim, Stuttgart, Germany
    Int J Toxicol 26:279-88. 2007
  6. ncbi HIV type 1 inhibition by protein kinase C modulatory compounds
    David Warrilow
    Division of Immunology and Infectious Disease, Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia
    AIDS Res Hum Retroviruses 22:854-64. 2006
  7. doi Isolation, stability and bioactivity of Jatropha curcas phorbol esters
    Joy S Roach
    Institute for Animal Production in the Tropics and Subtropics, 480b, University of Hohenheim, Stuttgart 70599, Germany
    Fitoterapia 83:586-92. 2012
  8. ncbi Prostratin antagonizes HIV latency by activating NF-kappaB
    Samuel A Williams
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, San Francisco, California 94141, USA
    J Biol Chem 279:42008-17. 2004
  9. pmc Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones
    I Rogatsky
    Department of Cellular and Molecular Pharmacology, University of California, 513 Parnassus Avenue, HSW1201, San Francisco, CA 94143 0450, USA
    EMBO J 20:6071-83. 2001
  10. ncbi Molecular characterization, reactivation, and depletion of latent HIV
    David G Brooks
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Immunity 19:413-23. 2003

Research Grants

  1. ARACHIDONATE METABOLISM IN BLOOD AND VASCULAR CELLS
    Kenneth Wu; Fiscal Year: 2002
  2. Activation of HTLV1 Gene Expression and Oncogenesis
    Arnold Rabson; Fiscal Year: 2006
  3. Regulation of Ovarian Cancer Multidrug Resistance by MAP Kinases
    Scott T Eblen; Fiscal Year: 2010
  4. PKC/PKA Regulation in Prostate Cancer by SSeCKS/Gravin/AKAP12
    Irwin H Gelman; Fiscal Year: 2010
  5. MECHANISMS OF MAMMALIAN FERTILIZATION/POLYSPERMY BLOCK
    GREGORY KOPF; Fiscal Year: 1990
  6. CELLULAR MECHANISMS IN THE INDUCTION OF AROMATASE
    CAROLE MENDELSON; Fiscal Year: 1993
  7. Prostate carcinogenesis and PKC signaling
    MARCELO GABRIEL KAZANIETZ; Fiscal Year: 2010
  8. MOLECULAR BIOLOGY OF BILE ACID SYNTHESIS
    JOHN CHIANG; Fiscal Year: 2001
  9. PROTEIN KINASE C AND PHOTORECEPTORS
    ALEXANDRA NEWTON; Fiscal Year: 2002
  10. CELLULAR MECHANISMS IN THE INDUCTION OF AROMATASE
    CAROLE MENDELSON; Fiscal Year: 1991

Detail Information

Publications202 found, 100 shown here

  1. ncbi Prostratin induces HIV activation and downregulates HIV receptors in peripheral blood lymphocytes
    Joaquín Rullas
    AIDS Immunopathogenesis Unit, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Madrid, Spain
    Antivir Ther 9:545-54. 2004
    ..These data support the potential use of prostratin to activate HIV from latency and purge viral reservoirs...
  2. pmc Effects of prostratin on T-cell activation and human immunodeficiency virus latency
    Yael D Korin
    Department of Medicine, UCLA School of Medicine, and UCLA AIDS Institute, 90095 1678, USA
    J Virol 76:8118-23. 2002
    ....
  3. ncbi Prostratin: activation of latent HIV-1 expression suggests a potential inductive adjuvant therapy for HAART
    J Kulkosky
    Dorrance H Hamilton Laboratories, Center for Human Virology, Division of Infectious Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Blood 98:3006-15. 2001
    ..This novel observation suggests the agent may be an excellent candidate to augment HAART by inducing expression of latent HIV-1 with the ultimate goal of eliminating persistent viral reservoirs in certain individuals infected with HIV-1...
  4. ncbi Protein kinase C and other diacylglycerol effectors in cancer
    Erin M Griner
    Department of Pharmacology and Institute for Translational Medicine and Therapeutics ITMAT, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
    Nat Rev Cancer 7:281-94. 2007
    ....
  5. ncbi Phorbol esters: structure, biological activity, and toxicity in animals
    Gunjan Goel
    Institute for Animal Production in the Tropics and Subtropics, University of Hohenheim, Stuttgart, Germany
    Int J Toxicol 26:279-88. 2007
    b>Phorbol esters are the tetracyclic diterpenoids generally known for their tumor promoting activity...
  6. ncbi HIV type 1 inhibition by protein kinase C modulatory compounds
    David Warrilow
    Division of Immunology and Infectious Disease, Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia
    AIDS Res Hum Retroviruses 22:854-64. 2006
    ..This result hints at the possibility of inhibition by a PKC modulatory compound of an early pathway of viral entry in PBMC...
  7. doi Isolation, stability and bioactivity of Jatropha curcas phorbol esters
    Joy S Roach
    Institute for Animal Production in the Tropics and Subtropics, 480b, University of Hohenheim, Stuttgart 70599, Germany
    Fitoterapia 83:586-92. 2012
    ..curcas seed oil, which can be utilized for biodiesel production upon transesterification, is also rich in phorbol esters (PEs). In this study, PEs from J...
  8. ncbi Prostratin antagonizes HIV latency by activating NF-kappaB
    Samuel A Williams
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, San Francisco, California 94141, USA
    J Biol Chem 279:42008-17. 2004
    ..These findings provide new insights into the molecular pathway through which prostratin antagonizes HIV latency highlighting a central role for the action of NF-kappaB...
  9. pmc Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones
    I Rogatsky
    Department of Cellular and Molecular Pharmacology, University of California, 513 Parnassus Avenue, HSW1201, San Francisco, CA 94143 0450, USA
    EMBO J 20:6071-83. 2001
    ..col3A, associated with the collagenase-3 gene in human U2OS osteosarcoma cells; col3A confers activation by phorbol esters, and repression by glucocorticoid and thyroid hormones...
  10. ncbi Molecular characterization, reactivation, and depletion of latent HIV
    David G Brooks
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Immunity 19:413-23. 2003
    ..We demonstrate that activation of latent virus is required for targeting by antiviral agents and provide the basis for future therapeutic strategies to eradicate the latent reservoir...
  11. ncbi Dramatic switching of protein kinase C agonist/antagonist activity by modifying the 12-ester side chain of phorbol esters
    Reiko Wada
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113 0033, Japan
    J Am Chem Soc 124:10658-9. 2002
    ..The approach of controlling the agonist/antagonist activity of phorbol esters by the nature (i.e., hydrophilicity, charge, and rigidity, etc...
  12. ncbi Phorbol esters modulate the Ras exchange factor RasGRP3
    P S Lorenzo
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892 4255, USA
    Cancer Res 61:943-9. 2001
    ..We show here that RasGRP3 bound phorbol esters with high affinity...
  13. doi Toxicity of Jatropha curcas phorbol esters in mice
    Cai Yan Li
    College of Animal Science, Zhejiang University, 310029 Hangzhou, PR China
    Food Chem Toxicol 48:620-5. 2010
    b>Phorbol esters are the main toxins in Jatropha curcas seed and oil. The aim of this study was to assess the acute toxicity of phorbol esters given by intragastric administration and to determine the LD50 for Swiss Hauschka mice...
  14. ncbi Cytotoxic action of phorbol esters on human pancreatic cancer cells
    Jane A Bond
    Department of Pathology, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom
    Int J Cancer 121:1445-54. 2007
    We previously showed that phorbol esters are cytotoxic to human thyroid epithelial cells expressing a mutant RAS oncogene...
  15. ncbi Distinct protein kinase C isoforms mediate regulation of vascular endothelial growth factor expression by A2A adenosine receptor activation and phorbol esters in pheochromocytoma PC12 cells
    Alicia M Gardner
    Department of Pharmacology and Cell Biophysics, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0575, USA
    J Biol Chem 278:15421-8. 2003
    ..Together, the findings suggest that phorbol ester-induced down-regulation of VEGF mRNA occurs as a result of a reduction of PKCepsilon activity, whereas that mediated by the A(2A)AR occurs following deactivation of PKCzeta...
  16. doi Biodegradation of Jatropha curcas phorbol esters in soil
    Rakshit K Devappa
    Institute for Animal Production in the Tropics and Subtropics 480b, University of Hohenheim, 70593 Stuttgart, Germany
    J Sci Food Agric 90:2090-7. 2010
    Jatropha curcas seed cake is generated as a by-product during biodiesel production. Seed cake containing toxic phorbol esters (PEs) is currently used as a fertiliser and thus it is of eco-toxicological concern...
  17. ncbi Phorbol esters inhibit the Hedgehog signalling pathway downstream of Suppressor of Fused, but upstream of Gli
    M Lauth
    Department of Biosciences and Nutrition, Karolinska Institutet, Novum Research Park, Huddinge, Sweden
    Oncogene 26:5163-8. 2007
    ....
  18. ncbi PKA and PKC enhance excitatory synaptic transmission in human dentate gyrus
    Huan Xin Chen
    Department of Neurological Surgery and Evelyn F and William L McKnight Brain Institute, Gainesville, Florida 32610, USA
    J Neurophysiol 89:2482-8. 2003
    ..In addition, the occlusion experiments suggest that the two kinases may share a common signal pathway...
  19. ncbi Prostratin and bortezomib are novel inducers of latent Kaposi's sarcoma-associated herpesvirus
    Helen J Brown
    Department of Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, CA, USA
    Antivir Ther 10:745-51. 2005
    ....
  20. ncbi Selective binding of phorbol esters and diacylglycerol by individual C1 domains of the PKD family
    Jun Chen
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Biochem J 411:333-42. 2008
    ..The twin C1 domains of PKD, designated C1a and C1b, have been shown to bind DAG or phorbol esters. However, their ligand-binding activities and selectivities have not been fully characterized...
  21. pmc The structural requirements for phorbol esters to enhance serotonin and acetylcholine release from rat brain cortex
    L Iannazzo
    Prince Henry s Institute of Medical Research, Victoria, Australia
    Br J Pharmacol 127:1177-89. 1999
    ..Another group of phorbol esters containing a common 13-ester substituent (phorbol 12,13-diacetate, PDA; phorbol 12-myristate 13-acetate, PMA; ..
  22. ncbi Chromaffin cell F-actin disassembly and potentiation of catecholamine release in response to protein kinase C activation by phorbol esters is mediated through myristoylated alanine-rich C kinase substrate phosphorylation
    S D Rose
    Secretory Process Research Program, Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
    J Biol Chem 276:36757-63. 2001
    ..These results provide the first evidence for MARCKS involvement in chromaffin cell secretion and suggest that regulation of cortical F-actin cross-linking might be involved in this process...
  23. doi Differential effects of phorbol-13-monoesters on human immunodeficiency virus reactivation
    Nieves Marquez
    Departamento de Biologia Celular, Fisiologia e Inmunologia, Facultad de Medicina, Avda de Menendez Pidal s n, 14004 Universidad de Córdoba, Spain
    Biochem Pharmacol 75:1370-80. 2008
    ..Nevertheless, this compound induces a translocation pattern of the PKC isotypes alpha and delta to cellular compartments distinctly different from that elicited by prostratin and PMA...
  24. ncbi Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters
    Nils Brose
    Abteilung Molekulare Neurobiologie, Max Planck Institut fur experimentelle Medizin, D 37075 Gottingen, Germany
    J Cell Sci 115:4399-411. 2002
    ..The most prominent intracellular targets of diacylglycerol and of the functionally analogous phorbol esters belong to the protein kinase C (PKC) family...
  25. pmc Characterization of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta
    Sung Hee Choi
    Laboratory of Cancer Biology and Genetics, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 283:10543-9. 2008
    C1 domains mediate the recognition and subsequent signaling response to diacylglycerol and phorbol esters by protein kinase C (PKC) and by several other families of signal-transducing proteins such as the chimerins or RasGRP...
  26. doi Modulation of the transient receptor potential vanilloid channel TRPV4 by 4alpha-phorbol esters: a structure-activity study
    Thomas Kjaer Klausen
    KU Leuven, Department of Molecular Cell Biology, Laboratory Ion Channel Research, Campus Gasthuisberg, Herestraat 49, Bus 802, Leuven, Belgium
    J Med Chem 52:2933-9. 2009
    The mechanism of activation of the transient receptor potential vanilloid 4 (TRPV4) channel by 4alpha-phorbol esters was investigated by combining information from chemical modification of 4alpha-phorbol-didecanoate (4alpha-PDD, 2a), site-..
  27. pmc Role of the regulatory domain of protein kinase D2 in phorbol ester binding, catalytic activity, and nucleocytoplasmic shuttling
    Alexandra Auer
    Department of Internal Medicine l, Medical University of Ulm, Ulm 89081, Germany
    Mol Biol Cell 16:4375-85. 2005
    Protein kinase D2 (PKD2) belongs to the PKD family of serine/threonine kinases that is activated by phorbol esters and G protein-coupled receptors (GPCRs)...
  28. ncbi Antimycobacterial activity of phorbol esters from the fruits of Sapium indicum
    Parinuch Chumkaew
    Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand
    J Nat Prod 66:540-3. 2003
    Three new phorbol esters, 12-(2-N-methylaminobenzoyl)-4beta,5,20-trideoxyphorbol-13-acetate (1), 12-(2-N-methylaminobenzoyl)-4alpha,5,20-trideoxyphorbol-13-acetate (2), and 12-(2-N-methylaminobenzoyl)-4alpha, 20-dideoxy-5-hydroxyphorbol-..
  29. pmc Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with a distinctive catalytic domain
    A M Valverde
    Imperial Cancer Research Fund, London, United Kingdom
    Proc Natl Acad Sci U S A 91:8572-6. 1994
    A serine/threonine protein kinase that binds phorbol esters and diacylglycerol (named protein kinase D, PKD) has been identified...
  30. pmc Potent and selective disruption of protein kinase D functionality by a benzoxoloazepinolone
    Elizabeth R Sharlow
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 283:33516-26. 2008
    ..In summary, our findings indicate that CID755673 is a potent and selective PKD1 inhibitor with valuable pharmacological and cell biological potential...
  31. ncbi A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1
    K R Gustafson
    Laboratory of Drug Discovery Research and Development, National Cancer Institute NCI, Frederick Cancer Research and Development Center FCRDC, Maryland 21702 1201
    J Med Chem 35:1978-86. 1992
    ..to and activated protein kinase C in vitro in CEM-SS cells and elicited other biochemical effects typical of phorbol esters in C3H10T1/2 cells; however, the compound does not appear to be a tumor promoter...
  32. pmc Phorbol esters and neurotransmitter release: more than just protein kinase C?
    Eugene M Silinsky
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, U S A
    Br J Pharmacol 138:1191-201. 2003
    This review focuses on the effects of phorbol esters and the role of phorbol ester receptors in the secretion of neurotransmitter substances...
  33. ncbi Phorbol esters induce intracellular accumulation of the anti-apoptotic protein PED/PEA-15 by preventing ubiquitinylation and proteasomal degradation
    Anna Perfetti
    Dipartimento di Biologia e Patologia cellulare e Molecolare DBPCM, Federico II University of Naples, Via Pansini 5, 80131 Naples, Italy
    J Biol Chem 282:8648-57. 2007
    ..Exposure of untransfected C5N keratinocytes and transfected HEK293 cells to phorbol esters (12-O-tetradecanoylphorbol-13-acetate (TPA)) increased PED/PEA-15 cellular content and enhanced its ..
  34. pmc Human immunodeficiency virus reactivation by phorbol esters or T-cell receptor ligation requires both PKCalpha and PKCtheta
    Sergey A Trushin
    Division of Infectious Diseases and Progam in Translational Immunology and Biodefense, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Virol 79:9821-30. 2005
    ..Antigens, T-cell receptor (TCR) ligation, and phorbol esters can reactivate HIV from latency in a protein kinase C (PKC)-dependent manner; however, it is unknown which ..
  35. ncbi Mechanisms of HIV receptor and co-receptor down-regulation by prostratin: role of conventional and novel PKC isoforms
    Marjan Hezareh
    AIDS Research Alliance, West Hollywood, Calif, USA
    Antivir Chem Chemother 15:207-22. 2004
    ..Altogether these results showed that prostratin, through the activation of conventional and/or novel PKC isoforms, rapidly reduces cell surface expression of CD4 and CXCR4, but not CCR5, by inducing their internalization and degradation...
  36. ncbi Inhibition of bovine immunodeficiency virus by anti-HIV-1 compounds in a cell culture-based assay
    G J Tobin
    Laboratory of Cell and Molecular Structure, SAIC Frederick, MD, USA
    Antiviral Res 33:21-31. 1996
    ....
  37. pmc Variability in content of the anti-AIDS drug candidate prostratin in Samoan populations of Homalanthus nutans
    HOLLY E JOHNSON
    Institute for Ethnomedicine, Box 3464, Jackson, Wyoming 83001, USA
    J Nat Prod 71:2041-4. 2008
    ..The reversed-phase HPLC assay will allow plants to be selected for agricultural development and genetic analysis by identifying those individuals above and below a 95% confidence interval for the median concentration...
  38. ncbi Regulated internalization and phosphorylation of the native norepinephrine transporter in response to phorbol esters. Evidence for localization in lipid rafts and lipid raft-mediated internalization
    Lankupalle D Jayanthi
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 279:19315-26. 2004
    ....
  39. pmc Substitution on the A-ring confers to bryopyran analogues the unique biological activity characteristic of bryostatins and distinct from that of the phorbol esters
    Gary E Keck
    Department of Chemistry, University of Utah, 315 South 1400 East, RM 2020, Salt Lake City, Utah 84112, USA
    Org Lett 11:593-6. 2009
    ..Biological assays reveal a crucial role for substitution in the bryostatin 1 A-ring in conferring those responses which are characteristic of bryostatin 1 and distinct from those observed with PMA...
  40. pmc Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+ T cells
    Tzu Ling Sung
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Retrovirology 3:66. 2006
    ..We also examined effects of prostratin on Cyclin T2a, an alternative regulatory subunit for CDK9, and 7SK snRNA and the HEXIM1 protein, two factors that associate with P-TEFb and repress its kinase activity...
  41. ncbi Potent and selective inhibition of HIV and SIV by prostratin interacting with viral entry
    Myriam Witvrouw
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium
    Antivir Chem Chemother 14:321-8. 2003
    ..We concluded that prostratin inhibits the entry step of the replication cycle of HIV by interacting with a cellular target necessary for viral entry...
  42. pmc A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters
    David M Roberts
    Curriculum in Genetics and Molecular Biology, Department of Biology, CB 3280, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Cell Biol 24:10515-28. 2004
    ..b>Phorbol esters mimic the second messenger diacylglycerol (DAG) in activating both protein kinase C (PKC) and non-PKC phorbol ..
  43. ncbi Activation of latent HIV-1 expression by the potent anti-tumor promoter 12-deoxyphorbol 13-phenylacetate
    Sven Bocklandt
    National Cancer Institute, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Antiviral Res 59:89-98. 2003
    ..The combination of high potency and anti-tumor promoting activity make DPP an attractive candidate for the adjunctive therapy of persistent HIV-1 infection...
  44. pmc Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4
    J Vriens
    Department of Physiology, Campus Gasthuisberg, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 101:396-401. 2004
    ..b>Phorbol esters and heat operate by means of a distinct, PLA(2)- and cytochrome p450 epoxygenase-independent pathway, which ..
  45. doi Phorbol esters modulate spontaneous and Ca2+-evoked transmitter release via acting on both Munc13 and protein kinase C
    Xuelin Lou
    Department of Membrane Biophysics, AG Synaptic Dynamics and Modulation, Max Planck Institute for Biophysical Chemistry, D 37077 Gottingen, Germany
    J Neurosci 28:8257-67. 2008
    Diacylglycerol (DAG) and phorbol esters strongly potentiate transmitter release at synapses by activating protein kinase C (PKC) and members of the Munc13 family of presynaptic vesicle priming proteins...
  46. pmc High-frequency epigenetic repression and silencing of retroviruses can be antagonized by histone deacetylase inhibitors and transcriptional activators, but uniform reactivation in cell clones is restricted by additional mechanisms
    Richard A Katz
    Institute for Cancer Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Virol 81:2592-604. 2007
    ..We conclude that HDACs can act rapidly to initiate and maintain promoter-independent retroviral epigenetic repression and silencing but that reactivation can be restricted by additional mechanisms...
  47. pmc Phorbol esters and adenosine affect the readily releasable neurotransmitter pool by different mechanisms at amphibian motor nerve endings
    T J Searl
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
    J Physiol 553:445-56. 2003
    b>Phorbol esters and adenosine have been proposed to interact at common sites downstream of calcium entry at amphibian motor nerve endings...
  48. ncbi Prostratin as a new therapeutic agent targeting HIV viral reservoirs
    Marjan Hezareh
    AIDS Research Alliance, West Hollywood, California, USA
    Drug News Perspect 18:496-500. 2005
    ..Prostratin represents a distinct subclass of protein kinase C activators, since unlike other phorbol esters it does not induce tumor formation...
  49. pmc Dual role of prostratin in inhibition of infection and reactivation of human immunodeficiency virus from latency in primary blood lymphocytes and lymphoid tissue
    Angelique Biancotto
    Unité de Pathogénie des Infections à Lentivirus, Parc Scientifique et Technologique de Luminy, INSERM U372, Marseille, France
    J Virol 78:10507-15. 2004
    ....
  50. pmc Practical synthesis of prostratin, DPP, and their analogs, adjuvant leads against latent HIV
    Paul A Wender
    Department of Chemistry, Stanford University, 337 Campus Drive, Stanford, CA 94305, USA
    Science 320:649-52. 2008
    ..This synthesis reliably supplies gram quantities of the therapeutically promising natural products, hitherto available only in low and variable amounts from natural sources, and opens access to a variety of new analogs...
  51. ncbi Swelling-activated Ca2+ entry via TRPV4 channel is defective in cystic fibrosis airway epithelia
    Maite Arniges
    Laboratori de Fisiologia Molecular, Unitat de Senyalització Cellular, Universitat Pompeu Fabra, C Dr Aiguader 80, Barcelona 08003, Spain
    J Biol Chem 279:54062-8. 2004
    ..Together, these results suggest that defective RVD in CF airway epithelia might be caused by the absence of a TRPV4-mediated Ca(2+) signal and the subsequent activation of Ca(2+)-dependent K(+) channels...
  52. ncbi Expression of latent HAART-persistent HIV type 1 induced by novel cellular activating agents
    Joseph Kulkosky
    Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    AIDS Res Hum Retroviruses 20:497-505. 2004
    ....
  53. ncbi A novel functional target for tumor-promoting phorbol esters and lysophosphatidic acid. The p21rac-GTPase activating protein n-chimaerin
    S Ahmed
    Institute of Molecular and Cell Biology, National University of Singapore
    J Biol Chem 268:10709-12. 1993
    b>Phorbol esters are potent tumor promoters widely used for investigating mechanisms of cell transformation with protein kinase C (PKC) generally considered as being their only protein target...
  54. ncbi Protein kinase C-dependent and -independent inhibition of Ca(2+) influx by phorbol ester in rat pancreatic beta-cells
    J Nakamura
    Department of Physiology, Hirosaki University School of Medicine, 5 Zaifu-cho, 036-8562, Hirosaki, Japan
    Cell Signal 13:199-205. 2001
    b>Phorbol esters were used to investigate the action of protein kinase C (PKC) on insulin secretion from pancreatic beta-cells...
  55. ncbi Opposing effects of calcium entry and phorbol esters on fusion of chick muscle cells
    M Rapuano
    Cellular and Developmental Biology Program, State University of New York, Stony Brook 11794
    Dev Biol 134:271-8. 1989
    ..We have investigated the effects of Ca2+ channel modulators and phorbol esters on fusion of embryonic chick myoblasts in culture...
  56. ncbi Phorbol esters and related analogs regulate the subcellular localization of beta 2-chimaerin, a non-protein kinase C phorbol ester receptor
    M J Caloca
    Center for Experimental Therapeutics and Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
    J Biol Chem 276:18303-12. 2001
    ..We have previously shown that, like PKCs, beta2-chimaerin binds phorbol esters with high affinity in a phospholipid-dependent manner (Caloca, M. J., Fernandez, M. N., Lewin, N. E., Ching, D...
  57. ncbi Phorbol esters affect skeletal muscle glucose transport in a fiber type-specific manner
    David C Wright
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Endocrinol Metab 287:E305-9. 2004
    ..However, earlier studies demonstrated that phorbol esters increase glucose transport in skeletal muscle...
  58. pmc Different pathways of calcium sensitization activated by receptor agonists and phorbol esters in vascular smooth muscle
    M Hori
    Department of Veterinary Pharmacology, Faculty of Agriculture, University of Tokyo, Japan
    Br J Pharmacol 110:1527-31. 1993
    1. It has been shown that receptor agonists and activators of protein kinase C, phorbol esters, increase Ca2+ sensitivity of contractile elements in vascular smooth muscle...
  59. ncbi Tyrosine phosphorylation of p130(cas) by bombesin, lysophosphatidic acid, phorbol esters, and platelet-derived growth factor. Signaling pathways and formation of a p130(cas)-Crk complex
    A Casamassima
    Imperial Cancer Research Fund, P O Box 123, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    J Biol Chem 272:9363-70. 1997
    ..Thus, our results identified distinct signal transduction pathways that lead to tyrosine phosphorylation of p130(cas) in the same cells and suggest that p130(cas) could play a role in mitogen-mediated signal transduction...
  60. ncbi The role of protein phosphorylation in alpha2,6(N)-sialyltransferase activity
    Kieran C Breen
    Department of Psychiatry, University of Dundee Medical School, Ninewells Hospital, UK
    Biochem Biophys Res Commun 309:32-5. 2003
    ..These results provide further evidence for the role of second messenger-associated kinase enzymes in the modulation of the cell glycosylation potential...
  61. ncbi Evidence that protein kinase Cdelta is not required for palmitate-induced cytotoxicity in BRIN-BD11 beta-cells
    H J Welters
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Plymouth, Devon, PL6 8BX, UK
    J Mol Endocrinol 32:227-35. 2004
    ..However, it is clear that PKCdelta is not required for this response...
  62. pmc Protein kinase C-mediated Ca2+ entry in HEK 293 cells transiently expressing human TRPV4
    Feng Xu
    Department of Pharmacology, Akita University School of Medicine, 1 1 1 Hondoh, Akita 010 8543, Japan
    Br J Pharmacol 140:413-21. 2003
    ..7 nm. Exposure to a hypotonic solution (HTS) after PMA further increased [Ca2+]i. Two other PKC-activating phorbol esters, phorbol 12,13-didecanoate (PDD) and phorbol 12,13-dibutyrate, also caused [Ca2+]i to increase. 3...
  63. ncbi Phorbol ester-dependent activation of peroxiredoxin I gene expression via a protein kinase C, Ras, p38 mitogen-activated protein kinase signaling pathway
    Alexander Hess
    Institut fur Klinische Chemie und Pathobiochemie, Justus Liebig Universitat Giessen, Giessen D 35392, Germany
    J Biol Chem 278:45419-34. 2003
    ..The data indicate that a protein kinase C, Ras, MEKK1, p38 MAPK signaling pathway plays a major role for the transcriptional up-regulation of Prx I gene expression...
  64. ncbi Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3
    Christine Teixeira
    Department of Biochemistry, University of Alberta, Edmonton, Canada
    Blood 102:1414-20. 2003
    ..of Ras activators have C1 domains that bind diacylglycerol (DAG) and DAG analogs such as the tumor-promoting phorbol esters. RasGRP members could be responsible for some of the DAG signaling processes that have previously been ..
  65. ncbi Tumor necrosis factor-alpha converting enzyme is processed by proprotein-convertases to its mature form which is degraded upon phorbol ester stimulation
    Kristina Endres
    Institute of Biochemistry, Johannes Gutenberg University, Mainz, Germany
    Eur J Biochem 270:2386-93. 2003
    ....
  66. ncbi Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression
    Hee Jung Chung
    Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 USA
    Science 300:1751-5. 2003
    ..In contrast, transfection with a point mutant that mimicked phosphorylation at Ser880 occluded subsequent LTD. Thus, PKC phosphorylation of GluR2 Ser880 is a critical event in the induction of cerebellar LTD...
  67. ncbi Regulation of HERG potassium channel activation by protein kinase C independent of direct phosphorylation of the channel protein
    Dierk Thomas
    Department of Cardiology, Medical University Hospital Heidelberg, Bergheimerstrasse 58, D 69115 Heidelberg, Germany
    Cardiovasc Res 59:14-26. 2003
    ..The aim of the present study was to elucidate the biochemical pathways of the protein kinase C (PKC)-dependent regulation of HERG currents...
  68. ncbi The chaperone protein 14-3-3 interacts with 3BP2/SH3BP2 and regulates its adapter function
    Isabelle Foucault
    INSERM U343 and Laboratoire d Immunologie, hôpital de l Archet I, Nice 06202, France
    J Biol Chem 278:7146-53. 2003
    ..Indeed, a 3BP2 mutant protein incapable of binding 14-3-3 showed increased capacity to stimulate NFAT transcriptional activities, suggesting that 14-3-3 binding to 3BP2 negatively regulates 3BP2 adapter function in lymphocytes...
  69. ncbi Phorbol ester induces CYP2E1 in astrocytes, through a protein kinase C- and tyrosine kinase-dependent mechanism
    Niclas Tindberg
    Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    J Neurochem 86:888-95. 2003
    ..g. cerebral injury, cytokines or phorbol ester, and mediated in part through protein kinase C...
  70. ncbi Effect of protein kinase C activation and inhibition on rat hepatic stellate cell activation
    Grant A Ramm
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, Missouri 63110 0250, USA
    Dig Dis Sci 48:790-6. 2003
    ..The demonstration that hepatic stellate cell activation can be suppressed by PKC inhibitors suggests a role for PKC in the regulation of hepatic stellate cell activation...
  71. ncbi Hyperoxia alters phorbol ester-induced phospholipase D activation in bovine lung microvascular endothelial cells
    Shukla Roy
    Department of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    Antioxid Redox Signal 5:217-28. 2003
    ..As protein tyrosine phosphorylation and PLD play important roles in inflammatory responses, this could provide a mechanism for the regulation of endothelial barrier function during hyperoxic lung injury...
  72. ncbi Direct, rapid effects of 25-hydroxyvitamin D3 on isolated intestinal cells
    Ruta Phadnis
    Department of Nutrition and Food Sciences and the Biotechnology Center, Utah State University, Logan, Utah 84322 8700, USA
    J Cell Biochem 90:287-93. 2003
    ..We conclude that 25(OH)D(3) has a direct effect on calcium handling in enterocytes of young animals that may in part be mediated by the protein kinase A signal transduction pathway...
  73. ncbi Phorbol ester-induced differentiation of L6 myogenic cells involves phospholipase D activation
    Hiba Komati
    Laboratoire de Physiopathologie des Lipides et Membranes, Institut National de la Santé et de la Recherche Médicale Unité 585, Institut National des Sciences Appliquees de Lyon, 69621 Villeurbanne, France
    FEBS Lett 577:409-14. 2004
    ..TPA-induced differentiation was inhibited by 1-butanol, confirming the involvement of PLD in this effect. These data suggest that prolonged elevation of PLD activity is required for myogenic differentiation...
  74. ncbi Differential regulation of GLAST immunoreactivity and activity by protein kinase C: evidence for modification of amino and carboxyl termini
    Bala T S Susarla
    Department of Pediatrics, University of Pennsylvania and Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    J Neurochem 91:1151-63. 2004
    ....
  75. ncbi Repression of 5-aminolevulinate synthase gene by the potent tumor promoter, TPA, involves multiple signal transduction pathways
    Alejandra S Guberman
    Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellon II Piso 4, Ciudad Universitaria, 1428 Buenos Aires, Argentina
    Arch Biochem Biophys 436:285-96. 2005
    ..Finally, by overexpression of a constitutively active p90RSK and the coactivator, cAMP-response element protein (CREB)-binding protein (CBP), we reinforced our previous model, that implies competition between AP-1 and CREB for CBP...
  76. ncbi Desensitization of nicotine acetylcholine receptors: modulation by kinase activation and phosphatase inhibition
    William Marszalec
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, 303 E Chicago Avenue, Chicago, IL 60611 3008, USA
    Eur J Pharmacol 514:83-90. 2005
    ..Protein kinase C activation or phosphatase 2B inhibition may favor the D1 receptor state over that of D2 to promote faster overall rates of desensitization recovery...
  77. ncbi Shp2 is required for protein kinase C-dependent phosphorylation of serine 307 in insulin receptor substrate-1
    Karsten Müssig
    Division of Endocrinology, Metabolism, and Pathobiochemistry, Department of Internal Medicine, University Hospital of Tubingen, Tubingen 72076, Germany
    J Biol Chem 280:32693-9. 2005
    ..Because the activation of these kinases does not depend on Shp2, it is concluded that the function of Shp2 is to direct these activated kinases to IRS-1...
  78. ncbi Opposing effects of phorbol-12-myristate-13-acetate, an activator of protein kinase C, on the signaling of structurally related human dopamine D1 and D5 receptors
    Adele Jackson
    Ottawa Health Research Institute, Ottawa Hospital Civic Campus, and Department of Medicine Cellular and Molecular Medicine Psychiatry, University of Ottawa, Ottawa, Ontario, Canada
    J Neurochem 95:1387-400. 2005
    ....
  79. ncbi Inhibition of the renal betaine transporter by calcium ions
    Stephen A Kempson
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Physiol Renal Physiol 291:F305-13. 2006
    ..Amino acid transport system A, assayed as a control, was not inhibited. Brief treatment with phorbol esters reproduced the specific inhibition of Na(+)-GABA cotransport, and the inhibition was blocked by staurosporine...
  80. pmc Calcium-dependent interactions of the human norepinephrine transporter with syntaxin 1A
    Uhna Sung
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232 8548, USA
    Mol Cell Neurosci 34:251-60. 2007
    ..Furthermore, PMA enhanced Ca2+-dependent modulation of NE transport in synaptosomes. Our data reveal roles for SYN1A in the Ca2+-dependent regulation of NET, likely reliant on regulation by PKC signaling, but independent of CaMK...
  81. ncbi Adapter molecule DOC-2 is differentially expressed in pressure and volume overload hypertrophy and inhibits collagen synthesis in cardiac fibroblasts
    Deepa H Kumbar
    The Heart Institute for Children, Advocate Hope Children s Hospital, Oak Lawn, IL, USA
    J Appl Physiol (1985) 102:2024-32. 2007
    ..Results suggest a role of DOC-2 in cardiac remodeling involving collagen expression during chronic hemodynamic overload...
  82. ncbi Interdependence of PKC-dependent and PKC-independent pathways for presynaptic plasticity
    Keimpe D B Wierda
    Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, The Netherlands
    Neuron 54:275-90. 2007
    ..Munc18-1 is an essential downstream target in the PKC pathway. This pathway is of general importance for presynaptic plasticity...
  83. ncbi Bidirectional regulation of renal cortical Na+,K+-ATPase by protein kinase C
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    Acta Biochim Pol 51:757-72. 2004
    ..The inhibitory effect is mediated by cytochrome P450-dependent arachidonate metabolites and PI3K, and is caused by redistribution of the sodium pump from the plasma membrane to the inactive intracellular pool...
  84. ncbi A role for ERK1/2 in EGF- and ATP-dependent regulation of amiloride-sensitive sodium absorption
    Rebecca Falin
    Case Western Reserve Univ, 2109 Adelbert Rd, Cleveland, OH 44106 4948, USA
    Am J Physiol Cell Physiol 288:C1003-11. 2005
    ....
  85. ncbi Activation of arylalkylamine N-acetyltransferase by phorbol esters in bovine pinealocytes suggests a novel regulatory pathway in melatonin synthesis
    C Schomerus
    Dr Senckenbergische Anatomie, Institut für Anatomie II, Johann Wolfgang Goethe Universitat Frankfurt, Frankfurt, Germany
    J Neuroendocrinol 16:741-9. 2004
    ..Other compounds which are known to influence the melatonin-generating system are phorbol esters. The effect of phorbol esters on regulation of melatonin synthesis has been mainly investigated in rat ..
  86. ncbi IL-4-dependent CD86 expression requires JAK/STAT6 activation and is negatively regulated by PKCdelta
    Eric L Deszo
    Department of Animal Sciences, College of Agriculture, Consumer and Environmental Sciences, 1207 West Gregory Dr, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Cell Signal 16:271-80. 2004
    ..We conclude from these data that IL-4-dependent CD11b expression relies predominantly on enhanced activation of ERK1/2, while IL-4-dependent CD86 expression utilizes the JAK/STAT6 pathway...
  87. ncbi Ca2+-dependent protein kinase C isoforms induce cholestasis in rat liver
    Ralf Kubitz
    Department of Gastroenterology, Hepatology, and Infectiology, Heinrich Heine University, D 40225 Dusseldorf, Germany
    J Biol Chem 279:10323-30. 2004
    ..The data identify Ca(2+)-dependent PKC isoforms as inducers of cholestasis. This is mainly due to inhibition of taurocholate excretion involving transporter retrieval from the canalicular membrane...
  88. ncbi Inhibition of human p53 basal transcription by down-regulation of protein kinase Cdelta
    Tarek Abbas
    Institute for Biomolecular Structure and Function and Department of Biological Sciences, Hunter College and Graduate School, City University of New York, New York 10021, USA
    J Biol Chem 279:9970-7. 2004
    ..kinase C (PKC) delta has been implicated as a tumor suppressor that is down-regulated by tumor-promoting phorbol esters in both mouse skin and cell culture models...
  89. pmc Studies on regulation of IGF (insulin-like growth factor)-binding protein (IGFBP) 4 proteolysis by pregnancy-associated plasma protein-A (PAPP-A) in cells treated with phorbol ester
    Arun S Sivanandam
    Musculoskeletal Disease Center, J L Pettis Memorial Veterans Medical Center, 11201 Benton Street, Loma Linda, CA 92357, USA
    Biochem J 379:57-64. 2004
    ..These data suggest that a novel mechanism, namely conversion of PAPP-A470 to the less-active PAPP-A400, could account for the TPA-induced suppression of PAPP-A activity...
  90. ncbi PKC activates BKCa channels in rat pulmonary arterial smooth muscle via cGMP-dependent protein kinase
    Scott A Barman
    Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912, USA
    Am J Physiol Lung Cell Mol Physiol 286:L1275-81. 2004
    ....
  91. pmc Protein kinase C-mediated phosphorylation of the leukemia-associated HOXA9 protein impairs its DNA binding ability and induces myeloid differentiation
    Ulka Vijapurkar
    Department of Medicine, University of California VA Medical Center, San Francisco, California 94121, USA
    Mol Cell Biol 24:3827-37. 2004
    ..These data suggest that phorbol ester-induced myeloid differentiation is in part due to PKC-mediated phosphorylation of HOXA9, which decreases the DNA binding of the homeoprotein...
  92. ncbi The cytosolic II-III loop of Cav2.3 provides an essential determinant for the phorbol ester-mediated stimulation of E-type Ca2+ channel activity
    Udo Klockner
    Institute of Vegetative Physiology, University of Cologne, Germany
    Eur J Neurosci 19:2659-68. 2004
    ..3 was eliminated. Receptor independent stimulation of PKC and its interaction with Ca(v)2.3 channels therefore represents an important positive feedback mechanism to decode electrical signals into a variety of cellular functions...
  93. ncbi Receptor activator of nuclear factor-kappaB is induced by a rottlerin-sensitive and p38 MAP kinase-dependent pathway during monocyte differentiation
    Hong Soon Kang
    Skeletal Diseases Genome Research Center, Kyungpook National University Hospital, Kyungpook National University, Daegu 700 412, Korea
    Mol Cells 17:438-45. 2004
    ..Together, these results demonstrate that expression of RANK is dependent upon a rottlerin-sensitive and p38MAPK-dependent pathway during monocyte differentiation...
  94. ncbi Combined action of extracellular signal-regulated kinase and p38 kinase rescues Molt4 T cells from nitric oxide-induced apoptotic and necrotic cell death
    Hyun Mee Oh
    Department of Microbiology and Immunology, Wonkwang University School of Medicine, Iksan, Chonbuk 570 749, South Korea
    Free Radic Biol Med 37:463-79. 2004
    ..Together, these findings suggest that the PMA-induced activations of ERK and p38 kinase are parallel events that are both required for inhibition of NO-induced death of Molt4 cells...
  95. ncbi Depolarization of skeletal muscle cells induces phosphorylation of cAMP response element binding protein via calcium and protein kinase Calpha
    Cesar Cardenas
    Centro de Estudios Moleculares de la Célula, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 7, Chile
    J Biol Chem 279:39122-31. 2004
    ..These results strongly implicate nuclear PKCalpha translocation in CREB phosphorylation induced by skeletal muscle membrane depolarization...
  96. pmc Neurokinin 2 receptor-mediated activation of protein kinase C modulates capsaicin responses in DRG neurons from adult rats
    Adrian Sculptoreanu
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA
    Eur J Neurosci 27:3171-81. 2008
    ..Thus, activation of NK2 autoreceptors by NKs released from the peripheral afferent terminals or by mast cells during inflammatory responses may be a mechanism that sensitizes TRPV1 channels and enhances afferent excitability...
  97. ncbi Cholecystokinin stimulates extracellular signal-regulated kinase through activation of the epidermal growth factor receptor, Yes, and protein kinase C. Signal amplification at the level of Raf by activation of protein kinase Cepsilon
    Albrecht Piiper
    Department of Internal Medicine II, University of the Saarland, D 66421 Homburg Saar, Germany
    J Biol Chem 278:7065-72. 2003
    ....
  98. ncbi Role of specific protein kinase C isozymes in mediating epidermal growth factor, thyrotropin-releasing hormone, and phorbol ester regulation of the rat prolactin promoter in GH4/GH4C1 pituitary cells
    Cheryl A Pickett
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA 98195 6426, USA
    Mol Endocrinol 16:2840-52. 2002
    ..Inhibitor data suggest that the EGF response may also involve Ca(2+)-dependent isozymes, whereas the TRH response appears to be more dependent on diacylglycerol...
  99. pmc Diacylglycerol generated by exogenous phospholipase C activates the mitogen-activated protein kinase pathway independent of Ras- and phorbol ester-sensitive protein kinase C: dependence on protein kinase C-zeta
    M van Dijk
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Biochem J 323:693-9. 1997
    ..The results suggest that DG generated by PC-PLC can activate the MAPK pathway independent of Ras and phorbol-ester-sensitive PKC but, instead, via PKC-zeta...
  100. ncbi Mesangial cell filamentous actin disassembly and hypocontractility in high glucose are mediated by PKC-zeta
    John A Dlugosz
    Institute of Medical Science and Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Am J Physiol Renal Physiol 282:F151-63. 2002
    ..In HG, altered F-actin and contractile functions in MCs are mediated by PKC-zeta...
  101. ncbi Activation of Ras, Raf-1 and protein kinase C in differentiating human neuroblastoma cells after treatment with phorbolester and NGF
    H Söderholm
    Tumour Biology, Department of Genetics and Pathology, The Rudbeck Laboratory, Uppsala University, SE 751 85, Uppsala, Sweden
    Cell Signal 13:95-104. 2001
    ..The results identify Raf-1 as a target for both TPA- and NGF-induced signals in differentiating SH-SY5Y/TrkA cells and demonstrate that signalling to Raf-1 was mediated via distinct mechanisms...

Research Grants74

  1. ARACHIDONATE METABOLISM IN BLOOD AND VASCULAR CELLS
    Kenneth Wu; Fiscal Year: 2002
    ..promoter which is switched to a more powerful distal promoter when cells are stimulated by cytokines and phorbol esters, (2) Aspirin suppresses the distal promoter activity of PGHS-1 gene...
  2. Activation of HTLV1 Gene Expression and Oncogenesis
    Arnold Rabson; Fiscal Year: 2006
    ..infected cell lines by treatment with immune activation related stimuli, such as phytohemagglutinin (PHA) and phorbol esters (PMA)...
  3. Regulation of Ovarian Cancer Multidrug Resistance by MAP Kinases
    Scott T Eblen; Fiscal Year: 2010
    ..phosphorylation in human ascites and in cell lines in response to chemotherapeutic drugs, oxidative stress, phorbol esters and UV irradiation...
  4. PKC/PKA Regulation in Prostate Cancer by SSeCKS/Gravin/AKAP12
    Irwin H Gelman; Fiscal Year: 2010
    Activation of protein kinase (PK) C has been considered cancer-promoting based on early data showing that phorbol esters could induce oncogenes is through the activation of so called classic and novel PKC isozymes...
  5. MECHANISMS OF MAMMALIAN FERTILIZATION/POLYSPERMY BLOCK
    GREGORY KOPF; Fiscal Year: 1990
    ..eggs retain their sperm receptor activity, but have lost the ability to induce a complete acrosome reaction; phorbol esters activate protein kinase C...
  6. CELLULAR MECHANISMS IN THE INDUCTION OF AROMATASE
    CAROLE MENDELSON; Fiscal Year: 1993
    ..there are distinct tissue- specific differences in the actions of several other regulatory factors, including phorbol esters, and a number of growth factors and cytokines...
  7. Prostate carcinogenesis and PKC signaling
    MARCELO GABRIEL KAZANIETZ; Fiscal Year: 2010
    The phorbol esters are natural compounds with tumor promoter activity that have been instrumental to define the stages of mutagen-initiated multistage carcinogenesis...
  8. MOLECULAR BIOLOGY OF BILE ACID SYNTHESIS
    JOHN CHIANG; Fiscal Year: 2001
    ..and an activator region in the promoter have been mapped to contain elements responsive to bile acid, phorbol esters and retinoic acid. Yeast one-hybrid system will be used to isolate DNA-binding proteins isolated...
  9. PROTEIN KINASE C AND PHOTORECEPTORS
    ALEXANDRA NEWTON; Fiscal Year: 2002
    ..of retinas with dopamine alters the phosphorylation of rhodopsin in a similar manner as treatment with phorbol esters, potent protein kinase C activators...
  10. CELLULAR MECHANISMS IN THE INDUCTION OF AROMATASE
    CAROLE MENDELSON; Fiscal Year: 1991
    ..b>Phorbol esters potentiate the cyclic AMP induction of aromatase activity in human adipose stromal cells...