phorbols

Summary

Summary: The parent alcohol of the tumor promoting compounds from CROTON OIL (Croton tiglium).

Top Publications

  1. ncbi Protein kinase C is involved in clozapine's facilitation of N-methyl-D-aspartate- and electrically evoked responses in pyramidal cells of the medial prefrontal cortex
    K E Jardemark
    Department of Psychiatry and Behavioral Science, Stony Brook University, Putnam Hall, South Campus, Stony Brook, NY 11794 8790, USA
    Neuroscience 118:501-12. 2003
  2. ncbi Induction of long-term depression and phosphorylation of the delta2 glutamate receptor by protein kinase C in cerebellar slices
    Tetsuro Kondo
    Molecular Neurophysiology, Neuroscience Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba 305 8566, Japan
    Eur J Neurosci 22:1817-20. 2005
  3. ncbi P-gp-induced modulation of regulatory volume increase occurs via PKC in mouse proximal tubule
    Yukio Miyata
    Department of Nephrology, Jichi Medical School, Tochigi, 329 0498 Japan
    Am J Physiol Renal Physiol 282:F65-76. 2002
  4. ncbi Functional expression of transient receptor potential vanilloid 4 in the mouse cochlea
    Jing Shen
    Hearing Research Laboratory, Department of Otolaryngology, Kansai Medical University, Moriguchi, Japan
    Neuroreport 17:135-9. 2006
  5. ncbi Production of matrix metalloproteinases in human cultured mast cells: involvement of protein kinase C-mitogen activated protein kinase kinase-extracellular signal-regulated kinase pathway
    Masahiro Kimata
    Department of Pharmacology, Gifu Pharmaceutical University, Gifu, Japan
    Allergol Int 55:67-76. 2006
  6. ncbi Effect of bursal anti-steroidogenic peptide and immunoglobulin G on neonatal chicken B-lymphocyte proliferation
    R W Moore
    Department of Poultry Science, Texas A and M University, College Station, TX 77843, USA
    Comp Biochem Physiol C Toxicol Pharmacol 134:291-302. 2003
  7. ncbi Effects of skin surface temperature on epidermal permeability barrier homeostasis
    Mitsuhiro Denda
    Shiseido Research Center, Kanazawa Ku, Yokohama, Japan
    J Invest Dermatol 127:654-9. 2007
  8. ncbi Modulation of TRPV4 gating by intra- and extracellular Ca2+
    Hiroyuki Watanabe
    Department of Physiology, Laboratorium voor Fysiologie, Campus Gasthuisberg, KU Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Cell Calcium 33:489-95. 2003
  9. ncbi Detection of a countertranscript in promyelocytic leukemia cells HL60 during early differentiation by TPA
    G Soma
    Biochem Biophys Res Commun 132:100-9. 1985
  10. ncbi Protective effect of melatonin and catalase in bovine neutrophil-induced model of mammary cell damage
    V Boulanger
    Dairy and Swine Research and Development Centre, Agriculture Agri Food Canada, Lennoxville, Quebec
    J Dairy Sci 85:562-9. 2002

Research Grants

  1. TUMOR CYTOLYSIS BY MONONUCLEAR LEUKOCYTES
    Dorothea Zucker Franklin; Fiscal Year: 1990
  2. New Synthetic Routes to Phorbols and Ingananes
    TIMO OVASKA; Fiscal Year: 2003
  3. SYNTHETIC STUDIES RELATED TO CANCER RESEARCH/TREATMENT
    Paul Wender; Fiscal Year: 2005
  4. Cellular Regulation of Salt Taste Transduction
    Vijay Lyall; Fiscal Year: 2008
  5. PHYSICOCHEMICAL INVESTIGATION OF TASTE
    Vijay Lyall; Fiscal Year: 2010

Scientific Experts

  • Jeewoo Lee
  • B Nilius
  • Martin Krøyer Rasmussen
  • S Mergler
  • M S Arenson
  • Timo V Ovaska
  • D G Johns
  • H R Behrman
  • Vijay Lyall
  • Kevin S Thorneloe
  • D Trotti
  • A Knox
  • M Denda
  • PAUL ANTHONY WENDER
  • Takashi Ueda
  • R W Moore
  • Undurti Das
  • M J Gunthorpe
  • Francesco Buonocore
  • Dorothea Zucker Franklin
  • Anna Garcia-Elias
  • Noriyuki Hatano
  • Yuka Itoh
  • C Troidl
  • Yang Zhang
  • Hiroyuki Watanabe
  • Nadege Kammoun Jellouli
  • Rui Wang
  • Naoto Yoshizuka
  • Diana Dahan
  • Masakazu Konno
  • Jian Xin Wan
  • W Schierling
  • Chao Wang
  • Katsuhiko Muraki
  • T Schmitz-Rixen
  • K Troidl
  • W Schaper
  • Miguel A Valverde
  • Rubén Vicente
  • Imam Baksh Baloch
  • Alberto Pagani
  • Shou Wei Yue
  • Lars Arendt-Nielsen
  • Yong Hui Wang
  • Hong You Ge
  • Atef Abdel Monem Abdel-Hafez
  • Bin Su
  • Zhuo Ma Dawa
  • Emad Afrasiabi
  • María Luz Orliac
  • V Benfenati
  • Ilhan Gurbuz
  • Masahiro Kimata
  • A Wesołowska
  • Jing Shen
  • Massimiliano G Bianchi
  • Lankupalle D Jayanthi
  • Yuji Matsuya
  • Tetsuro Kondo
  • K E Jardemark
  • Christopher J Howe
  • Charles M Marson
  • Guy Droogmans
  • Joris Vriens
  • V Boulanger
  • Masao Hattori
  • Norio Nakamura
  • Sahar El-Mekkawy
  • Yukio Miyata
  • Xowi K M S Mwimbi
  • George R Pettit
  • Cristina Plata
  • Emna Ellouz
  • Jian Yong Li
  • Rachelle Gaudet
  • Fanny Rubio-Moscardo
  • Hiroka Suzuki
  • Chanez Triki
  • Abdelaziz Tlili
  • Nacim Louhichi
  • Yan Ping Shi
  • Fatma Kammoun
  • Huan Yang Qi
  • Ikhlass Hadj Salem
  • Faiza Fakhfakh
  • Ute A Hellmich
  • Hitoshi Inada
  • Sanela Mrkonjic
  • Carlos Pardo-Pastor

Detail Information

Publications127 found, 100 shown here

  1. ncbi Protein kinase C is involved in clozapine's facilitation of N-methyl-D-aspartate- and electrically evoked responses in pyramidal cells of the medial prefrontal cortex
    K E Jardemark
    Department of Psychiatry and Behavioral Science, Stony Brook University, Putnam Hall, South Campus, Stony Brook, NY 11794 8790, USA
    Neuroscience 118:501-12. 2003
    ..Taken together, these results suggest that the PKC signal transduction pathway is critically involved in the facilitating action of clozapine on the NMDA-induced responses in pyramidal cells of the mPFC...
  2. ncbi Induction of long-term depression and phosphorylation of the delta2 glutamate receptor by protein kinase C in cerebellar slices
    Tetsuro Kondo
    Molecular Neurophysiology, Neuroscience Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba 305 8566, Japan
    Eur J Neurosci 22:1817-20. 2005
    ..Because this region of GluRdelta2 is known to associate with certain intracellular molecules, the PKC phosphorylation status of the C-terminus of GluRdelta2 may be involved in new signaling pathways during LTD...
  3. ncbi P-gp-induced modulation of regulatory volume increase occurs via PKC in mouse proximal tubule
    Yukio Miyata
    Department of Nephrology, Jichi Medical School, Tochigi, 329 0498 Japan
    Am J Physiol Renal Physiol 282:F65-76. 2002
    ..We conclude that 1) in the mouse proximal tubule, P-gp-induced modulation of RVI occurs via PKC; and 2) the microtubule, microfilament, and wortmannin-sensitive, LY-294002-insensitive PI 3-kinase contribute to the PKC-induced RVI...
  4. ncbi Functional expression of transient receptor potential vanilloid 4 in the mouse cochlea
    Jing Shen
    Hearing Research Laboratory, Department of Otolaryngology, Kansai Medical University, Moriguchi, Japan
    Neuroreport 17:135-9. 2006
    ..In conclusion, transient receptor potential vanilloid 4 may function as an osmosensory and a mechanosensory receptor in the cochlea...
  5. ncbi Production of matrix metalloproteinases in human cultured mast cells: involvement of protein kinase C-mitogen activated protein kinase kinase-extracellular signal-regulated kinase pathway
    Masahiro Kimata
    Department of Pharmacology, Gifu Pharmaceutical University, Gifu, Japan
    Allergol Int 55:67-76. 2006
    ..To confirm the role of mast cells as a source of MMPs, we investigated the production of MMP and its pathway in human cultured mast cells (HCMC). We also investigated the production of tissue inhibitors of metalloproteinase (TIMPs)...
  6. ncbi Effect of bursal anti-steroidogenic peptide and immunoglobulin G on neonatal chicken B-lymphocyte proliferation
    R W Moore
    Department of Poultry Science, Texas A and M University, College Station, TX 77843, USA
    Comp Biochem Physiol C Toxicol Pharmacol 134:291-302. 2003
    ....
  7. ncbi Effects of skin surface temperature on epidermal permeability barrier homeostasis
    Mitsuhiro Denda
    Shiseido Research Center, Kanazawa Ku, Yokohama, Japan
    J Invest Dermatol 127:654-9. 2007
    ..Previous reports suggest the existence of a water flux sensor in the epidermis, and as TRPV4 is known to be activated by osmotic pressure, our results indicate that it might be this sensor...
  8. ncbi Modulation of TRPV4 gating by intra- and extracellular Ca2+
    Hiroyuki Watanabe
    Department of Physiology, Laboratorium voor Fysiologie, Campus Gasthuisberg, KU Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Cell Calcium 33:489-95. 2003
    ....
  9. ncbi Detection of a countertranscript in promyelocytic leukemia cells HL60 during early differentiation by TPA
    G Soma
    Biochem Biophys Res Commun 132:100-9. 1985
    ..Thus we concluded that 0.7kb RNA is a countertranscript of 4.3kb RNA expressed during early differentiation of HL60 cells...
  10. ncbi Protective effect of melatonin and catalase in bovine neutrophil-induced model of mammary cell damage
    V Boulanger
    Dairy and Swine Research and Development Centre, Agriculture Agri Food Canada, Lennoxville, Quebec
    J Dairy Sci 85:562-9. 2002
    ..Our results suggest that hydroxyl radicals released by activated bovine neutrophils cause damage to mammary epithelial cells and that antioxidants may be useful to protect the mammary tissue during bovine mastitis...
  11. pmc Practical synthesis of prostratin, DPP, and their analogs, adjuvant leads against latent HIV
    Paul A Wender
    Department of Chemistry, Stanford University, 337 Campus Drive, Stanford, CA 94305, USA
    Science 320:649-52. 2008
    ..This synthesis reliably supplies gram quantities of the therapeutically promising natural products, hitherto available only in low and variable amounts from natural sources, and opens access to a variety of new analogs...
  12. ncbi Synthesis of new phorbol derivatives having ethereal side chain and evaluation of their anti-HIV activity
    Yuji Matsuya
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0914, Japan
    Bioorg Med Chem 13:4383-8. 2005
    ....
  13. ncbi Effect of gamma-linolenic acid and prostaglandins E1 on gamma-radiation and chemical-induced genetic damage to the bone marrow cells of mice
    Undurti N Das
    UND Life Sciences, 13800 Fairhill Road, 321, Shaker Heights, OH 44120, USA
    Prostaglandins Leukot Essent Fatty Acids 74:165-73. 2006
    ..PGE1 and its precursor GLA prevented gamma-radiation, DPH, BP, and 4-alpha-phorbol-induced genetic damage...
  14. ncbi The TRPV4 channel: structure-function relationship and promiscuous gating behaviour
    Bernd Nilius
    Department of Physiology, KU Leuven, Campus Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Pflugers Arch 446:298-303. 2003
    ..This channel is activated by various physical and chemical stimuli, such as cell swelling, heat, phorbols and, probably, by endogenous ligands, which are able to induce Ca(2+) entry...
  15. ncbi NMR structure of a protein kinase C-gamma phorbol-binding domain and study of protein-lipid micelle interactions
    R X Xu
    Glaxo Wellcome Research and Development, Research Triangle Park, North Carolina 27709, USA
    Biochemistry 36:10709-17. 1997
    ..Titrations of this domain with lipid micelles, in the absence and presence of phorbols, indicate selective broadening of some resonances...
  16. ncbi Isolation and structure of pedilstatin from a republic of maldives Pedilanthus sp
    George R Pettit
    Cancer Research Institute and Department of Chemistry and Biochemistry, Arizona State, University, Tempe 85287 2404, USA
    J Nat Prod 65:1262-5. 2002
    ..28 microg/mL, to afford, at concentrations of 2-5 microM, protection (to 80%) of human-derived lymphoblastoid CEM-SS cells from infection and cell-killing by HIV-1, and to show inhibition of protein kinase C with a K(i) of 620 +/- 20 nM...
  17. pmc Human immunodeficiency virus type 1 Nef protein down-regulates transcription factors NF-kappa B and AP-1 in human T cells in vitro after T-cell receptor stimulation
    J C Bandres
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    J Virol 68:3243-9. 1994
    ....
  18. ncbi Phorbol ester-induced ventricular fibrillation in the Langendorff-perfused rabbit heart: antagonism by staurosporine and glibenclamide
    S C Black
    University of Michigan Medical School, Ann Arbor 48109 0626
    J Mol Cell Cardiol 25:1427-38. 1993
    ..The latter prevented PDBu-induced VF. The results show that under the conditions employed, PDBu-induced activation of PKC induces redistribution of PKC activity and is associated with the development of VF...
  19. ncbi Inhibition of cytopathic effect of human immunodeficiency virus type-1 by various phorbol derivatives
    Sahar El-Mekkawy
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan
    Chem Pharm Bull (Tokyo) 50:523-9. 2002
    ..Both an increase and decrease in the number of fatty acid carbon chains resulted in significant reduction of the inhibition of CPE...
  20. ncbi Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives
    Hiroyuki Watanabe
    Department of Physiology, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    J Biol Chem 277:13569-77. 2002
    ..We concluded that the phorbol derivatives activate TRPV4 (VR-OAC, VRL-2, OTRPC4, TRP12) independently from protein kinase C, in a manner consistent with direct agonist gating of the channel...
  21. ncbi Functional differences between splice variants of the murine 5-HT(3A) receptor: possible role for phosphorylation
    P C Hubbard
    Division of Neurobiology, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Brain Res Mol Brain Res 81:101-8. 2000
    ..We conclude that the long and short forms of the 5-HT(3) receptor are differentially modulated by agents that activate PKA and PKC. These different patterns of modulation could have markedly divergent consequences on receptor function...
  22. ncbi Structures and solid state tautomeric forms of two novel antileukemic tropoloisoquinoline alkaloids, pareirubrines A and B, from Cissampelos pareira
    H Morita
    Department of Pharmacognosy, Tokyo College of Pharmacy, Japan
    Chem Pharm Bull (Tokyo) 41:1418-22. 1993
    ..Their structures were elucidated by nuclear magnetic resonance (NMR) studies, and their solid state tautomeric forms were examined by X-ray crystallographic analysis...
  23. ncbi Protein kinase C activation decreases activity-dependent attenuation of dendritic Na+ current in hippocampal CA1 pyramidal neurons
    C M Colbert
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurophysiol 79:491-5. 1998
    ....
  24. ncbi Inhibition of depolarisation-evoked [(3)H]noradrenaline release from SH-SYFY human neuroblastoma cells by muscarinic (M1) receptors is not mediated by changes in [Ca(2+)]
    D J Roberts
    Institute for Cardiovascular Research, University of Leeds, LS2 9JT, Leeds, UK
    Brain Res Mol Brain Res 87:81-91. 2001
    ..Thus this study shows that muscarine inhibits depolarisation-evoked NA release by a mechanism which is not dependent on activation of PKC or release of Ca(2+) from internal stores...
  25. pmc Phosphorylation and IGF-1-mediated dephosphorylation pathways control the activity and the pharmacological properties of skeletal muscle chloride channels
    A De Luca
    Dipartimento Farmacobiologico, Facolta di Farmacia, Universita di Bari, Italy
    Br J Pharmacol 125:477-82. 1998
    ..In turn the phosphorylation state of the channel can modulate the effects and the therapeutic potential of direct channel ligands...
  26. ncbi Restoration of TEA-induced calcium responses in fibroblasts from Alzheimer's disease patients by a PKC activator
    S Bhagavan
    Laboratory of Applied Neuroscience, Georgetown University Medical Center, Washington, DC 20007 2197, USA
    Neurobiol Dis 5:177-87. 1998
    ..The present study suggests that PKC activator-based restoration of K+ channels may offer another approach to the investigation of AD pathophysiology, which in turn could lead to the development of a useful model for AD therapeutics...
  27. ncbi The role of protein kinase C and novel phorbol ester receptors in tumor cell invasion and metastasis (Review)
    D E Gomez
    Laboratory of Molecular Oncology, Department of Science and Technology, Quilmes National University, 1876 Buenos Aires, Argentina
    Oncol Rep 6:1363-70. 1999
    ..In addition, we discuss the potential role of chimaerins, novel non-kinase phorbol ester receptors, in carcinogenesis...
  28. ncbi 4alpha-Phorbol negates the inhibitory effects of phorbol-12-myristate-13-acetate on human cilia and alters the phosphorylation of PKC
    Xowi K M S Mwimbi
    Tayside Institute of Child Health, Ninewells Hospital and Medical School, University of Dundee, UK
    FEBS Lett 530:31-6. 2002
    ..Thus, 4alpha-phorbol not only potently prevents PMA from inhibiting CBF but also has potent effects on the phosphorylation of PKC...
  29. pmc A novel function of p38-regulated/activated kinase in endothelial cell migration and tumor angiogenesis
    Naoto Yoshizuka
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, USA
    Mol Cell Biol 32:606-18. 2012
    ....
  30. ncbi Development of a novel gene silencer pyrrole-imidazole polyamide targeting human connective tissue growth factor
    Jian Xin Wan
    Division of Nephrology Hypertension and Endocrinology, Department of Medicine, School of Medicine, Nihon University, Tokyo, Japan
    Biol Pharm Bull 34:1572-7. 2011
    ..The PI polyamide to hCTGF significantly decreased PMA- or TGF-β1-stimulated levels of hCTGF protein in HMCs. These results indicate that the developed synthetic PI polyamide to hCTGF could be a novel gene silencer for fibrotic diseases...
  31. ncbi The TRPV4 channel is a novel regulator of intracellular Ca2+ in human esophageal epithelial cells
    Takashi Ueda
    Department of Neurobiology and Anatomy, Graduate School of Medical Sciences, Nagoya City University, Japan
    Am J Physiol Gastrointest Liver Physiol 301:G138-47. 2011
    ..Collectively, these findings suggest that TRPV4 is a novel regulator of Ca(2+)-dependent signaling pathways linked to cell proliferation, cell survival, ATP release, and IL-8 production in human esophageal epithelial cells...
  32. ncbi Cerebral arteriogenesis is enhanced by pharmacological as well as fluid-shear-stress activation of the Trpv4 calcium channel
    W Schierling
    Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany
    Eur J Vasc Endovasc Surg 41:589-96. 2011
    ..The expression profiles were analysed, comparing the stimulation of collateral growth by target-specific drugs to that achieved by maximum increased fluid shear stress (FSS)...
  33. ncbi Synthesis and biological evaluation of 12-aminoacylphorboids
    Alberto Pagani
    Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Universita del Piemonte Orientale, Novara, Italy
    J Nat Prod 73:447-51. 2010
    ..Selective PKC binding, rather than COX inhibition, might explain the paradoxical anti-inflammatory activity of extracts containing aminoacylphorboids in the mouse ear edema assay...
  34. pmc Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli
    Anna Garcia-Elias
    Laboratory of Molecular Physiology and Channelopathies, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona 08003, Spain
    Proc Natl Acad Sci U S A 110:9553-8. 2013
    ....
  35. ncbi IP3 receptor binds to and sensitizes TRPV4 channel to osmotic stimuli via a calmodulin-binding site
    Anna Garcia-Elias
    Laboratory of Molecular Physiology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Edifici PRBB, C Dr Aiguader 88, Barcelona 08003, Spain
    J Biol Chem 283:31284-8. 2008
    ..We conclude that IP3-mediated sensitization requires IP3 receptor binding to a TRPV4 C-terminal domain that overlaps with a previously described calmodulin-binding site...
  36. ncbi Two new tigliane diterpene esters from the flower buds of Daphne genkwa
    Rui Wang
    Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China
    J Asian Nat Prod Res 15:502-6. 2013
    ..The molecular structures of the isolated compounds were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR...
  37. pmc Suppression of aromatase in human breast cells by a cyclooxygenase-2 inhibitor and its analog involves multiple mechanisms independent of cyclooxygenase-2 inhibition
    Bin Su
    Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
    Steroids 73:104-11. 2008
    ..These results suggest that NS-398 and its N-methyl analog suppress aromatase expression and activity with multiple mechanisms...
  38. ncbi PKC-dependent stimulation of EAAT3 glutamate transporter does not require the integrity of actin cytoskeleton
    Massimiliano G Bianchi
    Unit of General and Clinical Pathology, Department of Experimental Medicine, University of Parma, Italy
    Neurochem Int 48:341-9. 2006
    ..In the absence of phorbols, latrunculin A, a toxin that disassembles actin cytoskeleton, produced a rapid inhibition of EAAT3 activity, due ..
  39. ncbi 2-Benzyl and 2-phenyl-3-hydroxypropyl pivalates as protein kinase C ligands
    Jeewoo Lee
    Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151 742, Republic of Korea
    Bioorg Med Chem 14:2022-31. 2006
    ..7 microM. The synthesized analogues were subjected to molecular modeling analysis based on two alternative models of the phorbol pharmacophore and a docking study of 13c was carried out...
  40. ncbi Models of anergy in the human Jurkat T cell line
    Christopher J Howe
    Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC 27858, USA
    Assay Drug Dev Technol 1:537-44. 2003
    ..Understanding the similarities and differences between these two models of anergy may lead to a better overall understanding of the anergic state of the T cell...
  41. ncbi Nuclear factor-kappa B mediates TRPV4-NO pathway involved in thermal hyperalgesia following chronic compression of the dorsal root ganglion in rats
    Chao Wang
    Department of Physical Medicine and Rehabilitation, Qilu Hospital, Medical School of Shandong University, Jinan 250012, China
    Behav Brain Res 221:19-24. 2011
    ..In conclusion, our data suggested that NF-κB could be involved in TRPV4-NO pathway in CCD-induced thermal hyperalgesia...
  42. ncbi An asymmetric synthesis of aza analogues of the tricyclic skeleton of daphnane and the ABC ring system of phorbol
    Charles M Marson
    Rhone Poulenc Rorer Ltd, Rainham Road South, Dagenham, Essex RM10 7XS, UK
    J Org Chem 68:792-8. 2003
    ..Subsequent demethylation and oxidative dearomatization of ring C afforded an enantiopure dienone 20 with the same relative and absolute configuration at the 9- and 10-positions of the phorbol skeleton...
  43. ncbi Molecular confirmation of founder mutation c.-167A>G in Tunisian patients with PMLD disease
    Nadege Kammoun Jellouli
    Laboratoire de Génétique Moléculaire Humaine Faculté de Médecine de Sfax Université de Sfax, Tunisia
    Gene 513:233-8. 2013
    ..The identification of this founder mutation has important implications towards genetic counseling in relatives of these families and the antenatal diagnosis...
  44. ncbi Characterization of lymphocyte stimulation by phorbol related compounds
    R S Dewdney
    British Industrial Biological Research Association, Carshalton, Surrey, UK
    Hum Toxicol 7:153-9. 1988
    ..4. Inter-individual differences were detected in the maximum response to the phorbols but not in their stimulating potency, as estimated by the concentration producing a half maximal response. 5...
  45. ncbi Bleomycin increases superoxide production in the most active alveolar macrophage subpopulation
    R B Zeidler
    Department of Anesthesiology, University of Missouri, School of Medicine, Columbia 65212
    Int J Immunopharmacol 9:691-6. 1987
    ..The cells have 9.1 +/- 1.0 x 10(5) sites/cell with a KD of 16 nmol. Results indicate that bleomycin may enhance superoxide production by effecting steps distal to protein kinase C in the superoxide anion production pathway...
  46. pmc Platelet-derived growth factor mimics phorbol diester action on epidermal growth factor receptor phosphorylation at threonine-654
    R J Davis
    Proc Natl Acad Sci U S A 82:4080-4. 1985
    ..The data further suggest that protein kinase C may play an important role in the regulation of cellular metabolism and proliferation by PDGF...
  47. ncbi Characterization of bradykinin-induced phosphoinositide turnover in neurohybrid NCB-20 cells
    D M Chuang
    Laboratory of Preclinical Pharmacology, National Institute of Mental Health, St Elizabeths Hospital, Washington, DC 20032
    J Neurochem 51:505-13. 1988
    ..Pretreatment of cells with pertussis toxin induced only about 30% loss of the bradykinin-induced [3H]IP1 accumulation, without affecting basal activity.(ABSTRACT TRUNCATED AT 250 WORDS)..
  48. ncbi Heterologous down-regulation of vascular atrial natriuretic peptide receptors by phorbol esters
    Y Hirata
    Hypertension Endocrine Division, National Cardiovascular Center Research Institute, Osaka, Japan
    Biochem Biophys Res Commun 152:1097-103. 1988
    ..These data suggest that protein kinase C may be involved in the mechanism of heterologous down-regulation of vascular ANP receptors/guanylate cyclase system...
  49. ncbi Na+-dependent elevation of the acidic cell surface pH (microclimate pH) of rat jejunal villus cells induced by cyclic nucleotides and phorbol ester: possible mediators of the regulation of the Na+/H+ antiporter
    T Shimada
    Department of Physiology, Faculty of Medicine, University of Tokyo, Japan
    Biochim Biophys Acta 937:328-34. 1988
    ....
  50. ncbi Role of voltage-sensitive calcium channels in [Ca2+]i and secretory responses to activators of protein kinase C in pituitary gonadotrophs
    S Izumi
    Endocrinology and Reproduction Research Branch, National Institutes of Child Health and Human Development, NIH, Bethesda, Maryland 20892
    Biochem Biophys Res Commun 170:359-67. 1990
    ..of [Ca2+]i using Fura-2 and of LH release during cell perifusion studies revealed that the initial effects of phorbols and permeant diacylglycerols on these responses are extracellular Ca2(+)-dependent and are mediated through ..
  51. pmc Sensitizing stimuli cause translocation of protein kinase C in Aplysia sensory neurons
    T C Sacktor
    Howard Hughes Medical Institute, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032
    Proc Natl Acad Sci U S A 87:2036-9. 1990
    ....
  52. ncbi The effect of alpha-adrenergic agents and protein kinase C activators on protein phosphorylation in isolated guinea pig hearts
    I Edes
    2nd Department of Medicine, Albert Szent Gyorgyi Medical University, Szeged, Hungary
    Eur Heart J 12:143-4. 1991
    ..These findings indicate that the major cardiac regulatory phosphoproteins, which have been reported to serve as substrates for protein kinase C in vitro, are not phosphorylated by the same enzyme in perfused, beating guinea pig hearts...
  53. ncbi A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1
    K R Gustafson
    Laboratory of Drug Discovery Research and Development, National Cancer Institute NCI, Frederick Cancer Research and Development Center FCRDC, Maryland 21702 1201
    J Med Chem 35:1978-86. 1992
    ..formation characteristic of the nonpromoting 12-deoxyphorbol 13-phenylacetate, and failed to induce the acute or chronic hyperplasias typically caused by tumor-promoting phorbols at doses of 1/100 or less than that used for prostratin.
  54. ncbi Potent constrictor actions of endothelin-1, endothelin-2, and endothelin-3 in rat isolated portal vein
    C L Guimaraes
    Department of Pharmacology, Universidade Federal de Santa Catarina, Florianopolis, Brazil
    Hypertension 19:II79-86. 1992
    ..Their action appears to rely largely on Ca2+ influx from the external medium (only in part via L- and T-type Ca2+ channels) and activation of protein kinase C but not on eicosanoid generation.(ABSTRACT TRUNCATED AT 250 WORDS)..
  55. ncbi Actions of phorbol esters on levels of cAMP in cholera toxin-treated chief cells from guinea pig stomach
    J P Raufman
    Department of Medicine, State University of New York, Health Science Center, Brooklyn 11203 2098
    Biochim Biophys Acta 1135:61-6. 1992
    ..Combination of phorbol esters that activate protein kinase C with ionophores that increase cell calcium mimics the actions of CCK and carbachol on cAMP levels in cholera toxin-treated chief cells...
  56. ncbi Phorbol esters, bombesin and insulin elicit differential responses on the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase system in primary cultures of foetal and adult rat hepatocytes
    M Cascales
    Instituto de Bioquimica, Facultad de Farmacia, Ciudad Universitaria, Madrid, Spain
    Eur J Biochem 207:391-7. 1992
    ....
  57. ncbi A keratin of fetal skin is reexpressed in human keratinocytes transformed by SV40 virus or treated with the tumor promoter TPA
    M Darmon
    Exp Cell Res 154:315-9. 1984
    ..Differentiation 23 (1982) 170. [23]), it suggests that SV40 virus and TPA are able to induce in human keratinocytes the reexpression of fetal characters...
  58. pmc Phorbol ester-induced M-current suppression in bull-frog sympathetic ganglion cells: insensitivity to kinase inhibitors
    H Chen
    Department of Pharmacology, University of Alberta, Edmonton, Canada
    Br J Pharmacol 113:55-62. 1994
    ..The availability of such a mechanism poses new questions as to the mechanism of muscarine-induced IM suppression...
  59. pmc Phorbol ester-induced differentiation of chronic B lymphocytic leukaemia cells--regulatory impact of autologous and allogeneic accessory cells
    A Danersund
    Clin Exp Immunol 59:644-52. 1985
    ..Furthermore, the Ig secretory response of CLL populations seems to be correlated with the surface Ig the surface immunoglobulin phenotype of the leukaemic cells...
  60. ncbi Characterization of transient receptor potential vanilloid channel 4 (TRPV4) in human corneal endothelial cells
    Stefan Mergler
    Charite Universitatsmedizin Berlin, Campus Virchow Clinic, Department of Ophthalmology, Augustenburger Platz 1, 13353 Berlin, Germany
    Exp Eye Res 93:710-9. 2011
    ..There is functional TRPV4 expression in HCEC-12 and in its clonal daughter cell lines based on Ca(2+) transients and underlying currents induced by known activators of this channel...
  61. ncbi Tumour promoter phorbol-12-myristate-13-acetate induces chromosomal damage via indirect action
    I Emerit
    Nature 293:144-6. 1981
  62. ncbi TRPV4 partially participates in proliferation of human brain capillary endothelial cells
    Noriyuki Hatano
    Laboratory of Cellular Pharmacology, School of Pharmacy, Aichi Gakuin University, 1 100 Kusumoto, Chikusa, Nagoya 464 8650, Japan
    Life Sci 92:317-24. 2013
    ....
  63. ncbi Implication of the ryanodine receptor in TRPV4-induced calcium response in pulmonary arterial smooth muscle cells from normoxic and chronically hypoxic rats
    Diana Dahan
    Universite de Bordeaux, Centre de Recherche Cardio Thoracique de Bordeaux, France
    Am J Physiol Lung Cell Mol Physiol 303:L824-33. 2012
    ..This study provides new insights onto the complex calcium signaling in PASMC and point out the importance of the TRPV4-RyR2 signaling pathway under hypoxic conditions that may lead to pulmonary hypertension...
  64. pmc Tumor promoter 12-O-tetradecanoylphorbol 13-acetate, like epidermal growth factor, stimulates cell proliferation and inhibits differentiation of mouse mammary epithelial cells in culture
    Y Taketani
    Proc Natl Acad Sci U S A 80:1646-9. 1983
    ..These results indicate that TPA, like EGF, switches the developmental course of mammary epithelium from differentiation to proliferation...
  65. ncbi Stimulation of transient receptor potential vanilloid 4 channel suppresses abnormal activation of microglia induced by lipopolysaccharide
    Masakazu Konno
    Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    Glia 60:761-70. 2012
    ..These results suggest that depolarization in response to opening of the TRPV4 channel attenuates the driving force for extracellular Ca(2+) and suppresses microglial activation...
  66. ncbi Further characterization of 5-HT- and 5-HT3 receptor agonists'-stimulated phosphoinositol phosphates accumulation
    E Edwards
    Department of Pharmacology and Toxicology, University of Maryland, Baltimore 21201
    Brain Res 617:113-9. 1993
    ..5 and 1 microgram) had no effect on either 5-HT's or 2-Me-5-HT's increased stimulation of PI hydrolysis, suggesting that this response is not associated to a Gi GTP binding protein...
  67. ncbi A transient receptor potential vanilloid 4 contributes to mechanical allodynia following chronic compression of dorsal root ganglion in rats
    Yang Zhang
    Department of Physical Medicine and Rehabilitation, Qilu Hospital, Medical School of Shandong University, Jinan 250012, China
    Neurosci Lett 432:222-7. 2008
    ..These increased responses were significantly inhibited by TRPV4 antisense ODN. In conclusion, TRPV4 plays a crucial role in CCD-induced mechanical allodynia...
  68. ncbi [Secretion of peptide YY and truncated glucagon-like peptide 1 by isolated intestinal cells in rats]
    S Saifia
    Unité INSERM 45, Hopital Edouard Herriot, Lyon
    Gastroenterol Clin Biol 18:447-55. 1994
    ..At gel chromatography, the immunoreactive PYY and TGLP1 material in cell extracts and in release medium co-eluted with the respective synthetic peptides.(ABSTRACT TRUNCATED AT 250 WORDS)..
  69. ncbi Phosphorylation of aortic plasma membranes by protein kinase C
    D Y Zhao
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Calgary, Alberta, Canada
    Mol Cell Biochem 106:171-80. 1991
    ..Immunoblotting established that calpactin II was present in aortic plasma membranes, but there was no corresponding phosphoprotein on the autoradiographs...
  70. ncbi Expression and functional characterization of transient receptor potential vanilloid-related channel 4 (TRPV4) in rat cortical astrocytes
    V Benfenati
    Department of Human and General Physiology, University of Bologna, Via S Donato 19 2, 40127 Bologna, Italy
    Neuroscience 148:876-92. 2007
    ..Consistent with its roles in other tissues, these results support the view that TRPV4 might participate in astroglial osmosensation and thus play a key role in brain volume homeostasis...
  71. ncbi Increases in vanilloid TRPV1 receptor protein and CGRP content during endotoxemia in rats
    María Luz Orliac
    Instituto de Investigaciones Farmacológicas ININFA CONICET, Junin 956, 5 piso C1113AAD Buenos Aires, Argentina
    Eur J Pharmacol 566:145-52. 2007
    ..An eventual phosphorylation event linked to the overflow of CGRP could also participate in the enhanced relaxation caused by anandamide in endotoxemia...
  72. ncbi Evaluation of the anti-ulcerogenic effect of sesquiterpene lactones from Centaurea solstitialis L. ssp. solstitialis by using various in vivo and biochemical techniques
    Ilhan Gurbuz
    Gazi University, Faculty of Pharmacy, Department of Pharmacognosy, Etiler, 06330 Ankara, Turkey
    J Ethnopharmacol 112:284-91. 2007
    ..On the other hand, active compounds did not show any toxic effect on acute toxicity (3 days administration) evaluation tests in mice...
  73. ncbi Hormone induction of ascorbic acid transport in immature granulosa cells
    H R Behrman
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Endocrinology 137:4316-21. 1996
    ..The hormone-dependent induction of ascorbic acid accumulation in granulosa cells appears to be an essential process for the development and maintenance of a viable follicle...
  74. pmc Differential regulation of phospholipase D and phospholipase A2 by protein kinase C in P388D1 macrophages
    J Balsinde
    Department of Chemistry, University of California at San Diego, La Jolla 92093 0601, U S A
    Biochem J 321:805-9. 1997
    ..This has hitherto been difficult to achieve because of the lack of specific inhibitors of these two phospholipases...
  75. ncbi Analgesic and sedative activities of lactucin and some lactucin-like guaianolides in mice
    A Wesołowska
    Department of New Drugs Research, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Str, 31 343 Krakow, Poland
    J Ethnopharmacol 107:254-8. 2006
    ..Lactucopicrin appeared to be the most potent analgetic of the three tested compounds. Lactucin and lactucopicrin, but not 11beta,13-dihydrolactucin, also showed sedative properties in the spontaneous locomotor activity test...
  76. ncbi Protein kinase C plays an inhibitory role in interleukin 3- and interleukin 4-mediated mast cell proliferation
    E Chaikin
    Institute of Biochemistry, Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Biol Chem 265:22109-16. 1990
    ..These results indicate that PKC plays an important inhibitory role in IL-3- and IL-4-mediated proliferation of BMMC...
  77. ncbi Identification of Na(+)-H+ exchange in human normal and cystic fibrotic ciliated airway epithelium
    A M Paradiso
    Department of Medicine, University of North Carolina, Chapel Hill 27599
    Am J Physiol 262:L757-64. 1992
    ..The results provide evidence in support of an amiloride-sensitive PMA-activated Na(+)-H+ exchanger in ciliated HNE cells from normal and CF donors...
  78. ncbi Phorbol 12-myristate 13-acetate inhibits FRO anaplastic human thyroid cancer cell proliferation by inducing cell cycle arrest in G1/S phase: evidence for an effect mediated by PKCdelta
    Emad Afrasiabi
    Department of Biology, Abo Akademi University, BioCity, Artillerigatan 6, 20520 Turku, Finland
    Mol Cell Endocrinol 292:26-35. 2008
    ..The results indicate that PMA is an effective inhibitor of thyroid cancer cell proliferation and migration by a mechanism involving PKC-MAP kinase/Akt and FOXO signaling...
  79. ncbi [Studies on chemical constituents of Saussurea laniceps]
    Zhuo Ma Dawa
    Tibet Autonomous Region Institute for Food and Drug Control, Lhasa 850000, China
    Zhongguo Zhong Yao Za Zhi 33:1032-5. 2008
    ..To investigate the chemical constituents of Saussurea laniceps...
  80. ncbi An environmental sensor, TRPV4 is a novel regulator of intracellular Ca2+ in human synoviocytes
    Yuka Itoh
    Laboratory of Cellular Pharmacology, School of Pharmacy, Aichi Gakuin University, Chikusa, Nagoya 464 8650, Japan
    Am J Physiol Cell Physiol 297:C1082-90. 2009
    ..Treatment of RA but not MH7A cells with 4alphaPDD for 24 h reduced their production of IL-8. These results suggest that an environmental sensor, TRPV4, is a novel regulator of intracellular Ca(2+) in human synoviocytes...
  81. ncbi [Chemical control of gene expression]
    Y Hashimoto
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
    Yakugaku Zasshi 114:357-73. 1994
    ..Development of more potent and/or more specific gene expression modifiers might be useful in cancer chemotherapy...
  82. ncbi Sequence and expression of human protein kinase C-epsilon
    P Basta
    Sphinx Pharmaceuticals Corporation, Molecular Biology Section, Durham, NC 27717
    Biochim Biophys Acta 1132:154-60. 1992
    ..The recombinant protein was also recognized by two distinct epsilon-specific polyclonal antibodies...
  83. ncbi Modulation of IK,Ca by phorbol ester-mediated activation of PKC in pleural sensory neurons of Aplysia
    S D Critz
    Department of Neurobiology and Anatomy, University of Texas Medical School, Houston 77225
    J Neurophysiol 68:1079-86. 1992
    ..These results indicate that at least one component of the modulation of IK,Ca by PDBu was independent of the modulation of voltage-dependent Ca2+ channels.(ABSTRACT TRUNCATED AT 250 WORDS)..
  84. pmc Toxic inhibition of smooth muscle contractility by plant-derived sesquiterpenes caused by their chemically reactive alpha-methylenebutyrolactone functions
    A J Hay
    Pharmacology Group, King s College, London
    Br J Pharmacol 112:9-12. 1994
    ..4. Thus the alpha-methylene function is critical for this aspect of the toxic pharmacological profile of the sesquiterpene butyrolactones, which are natural products widely distributed in the Compositae family of flowering plants...
  85. ncbi N-((1S)-1-{[4-((2S)-2-{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a novel and potent transient receptor potential vanilloid 4 channel agonist induces urinar
    Kevin S Thorneloe
    Cardiovascular and Urogenital Centre of Excellence in Drug Discovery, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, King of Prussia, PA 19406, USA
    J Pharmacol Exp Ther 326:432-42. 2008
    ..Overall TRPV4 plays an important role in urinary bladder function that includes an ability to contract the bladder as a result of the expression of TRPV4 in the UBSM...
  86. ncbi Toxic effects of solstitialin A 13-acetate and cynaropicrin from Centaurea solstitialis L. (Asteraceae) in cell cultures of foetal rat brain
    C H Cheng
    Postgraduate Studies in Pharmacology, School of Pharmacy, University of Bradford, West Yorkshire, U K
    Neuropharmacology 31:271-7. 1992
    ....
  87. ncbi Calcium-dependent signalling is essential during collateral growth in the pig hind limb-ischemia model
    C Troidl
    Franz Groedel Institute of the Kerckhoff Heart and Thorax Center, Benekestr 2 8, 61231 Bad Nauheim, Germany
    J Mol Cell Cardiol 49:142-51. 2010
    ..Subcellularly, modulation of Ca(2+)-dependent transcription factors indicates a pivotal role for Ca(2+)-signalling during arteriogenesis...
  88. ncbi State and activity of protein kinase C in postischemic reperfused liver
    R Piccoletti
    Istituto di Patologia Generale, Universita degli Studi di Milano, Italy
    Exp Mol Pathol 56:219-28. 1992
    ..Total phospholipids, phosphatidylcholine, and phosphatidylethanolamine, which significantly decrease at 60 min of ischemia, return to normal levels 1 hr after reperfusion...
  89. ncbi Schistosomiasis suppressing deoxyphorbol esters from Euphorbia cauducifolia L. latex
    Imam Baksh Baloch
    Department of Chemistry, Gomal University, Dera Ismail Khan, Pakistan
    Planta Med 76:809-14. 2010
    ..Compounds 1 and 2, which were esterified at C-13 with acetoxy or N-(2-aminobenzoyl) anthraniloyloxy, showed twice the activity of the control while others ( 3- 8) were equipotent...
  90. ncbi Inhibition of myosin light chain phosphatase during Ca(2+)-independent vasocontraction
    H Itoh
    First Department of Internal Medicine, Faculty of Medicine, University of Mie, Japan
    Am J Physiol 265:C1319-24. 1993
    ..These results suggest that the regulation of MLC phosphatase in vascular smooth muscle may play important roles in the PDB-induced contraction and the NKH477-induced relaxation in Ca(2+)-free buffer...
  91. pmc Regulation of the benzamil-insensitive salt taste receptor by intracellular Ca2+, protein kinase C, and calcineurin
    Vijay Lyall
    Department of Physiology and Biophysics, Virginia Commonwealth University, Sanger Hall, Room 3 010, 1101 E Marshall St, Richmond, VA 23298 0551, USA
    J Neurophysiol 102:1591-605. 2009
    ..We conclude that TRPV1 or its variant TRPV1t is phosphorylated and dephosphorylated by PKC and PP2B, respectively, and either sensitizes or desensitizes the Bz-insensitive NaCl chorda tympani responses to RTX stimulation...
  92. ncbi [Sesquiterpenelactones of Achillea setacea with antiphlogistic activity]
    K Zitterl-Eglseer
    Institut für Botantik und Lebensmittelkunde, Veterinärmedizinischen Universität Wien, Austria
    Planta Med 57:444-6. 1991
    ..Achillicin, achillin, 8-hydroxyachillin, 8-acetoxyachillin, and matricin could not be detected in A. setacea. For both rupicolin B and 11,13-dehydrodeacetylmatricarin an anti-inflammatory activity was found in the croton oil ear test...
  93. ncbi Modulation of adenylate cyclase in human keratinocytes by protein kinase C
    E J Choi
    Division of Biological Sciences, Harvard University School of Public Health, Boston, Massachusetts 02115
    J Biol Chem 263:17167-72. 1988
    ....
  94. pmc Tumor-promoting phorbol esters support the in vitro proliferation of murine pluripotent hematopoietic stem cells
    J L Spivak
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    J Clin Invest 83:100-7. 1989
    ..Together, the data indicate that tumor-promoting phorbol esters interact with pluripotent hematopoietic stem cells. Like IL 3, their effect appears to be permissive and involves stem cells with marrow repopulating ability...
  95. ncbi Production and characterization of a continuous embryonic cell line from sea bass (Dicentrarchus labrax L.)
    Francesco Buonocore
    Dipartimento di Scienze Ambientali, Universita della Tuscia, Largo dell Universita, I 0110, Viterbo, Italy
    Mar Biotechnol (NY) 8:80-5. 2006
    ..They have been transfected using liposomes with a commercial plasmid vector containing a reporter gene, thus suggesting a possible importance as an alternative expression system of recombinant vertebrate proteins in teleost cells...
  96. ncbi Activation-dependent phosphorylation of endogenous protein kinase C substrates in quiescent human T lymphocytes
    B Friedrich
    Unit for Applied Cell and Molecular Biology, University of Umea, Sweden
    Immunobiology 176:465-78. 1988
    ..C pathway. The biological significance of these phosphorylation events was suggested both by the ligand specificity and the correlation with subsequent induction of cellular proliferation...
  97. ncbi Inhibition of the glutamate transporter EAAC1 expressed in Xenopus oocytes by phorbol esters
    D Trotti
    Membrane Biology Program, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Brain Res 914:196-203. 2001
    ..Because activation of PKC by phorbol esters leads to opposite effects on EAAC1 activity in different culture models, we conclude that the PKC-mediated regulation of EAAC1 is cell-type specific...
  98. ncbi Protein kinase C isozymes, novel phorbol ester receptors and cancer chemotherapy
    O P Barry
    Cork Cancer Research Center and Department of Medicine, Clinical Science Building, Cork University Hospital, Wilton Road, Cork, Ireland
    Curr Pharm Des 7:1725-44. 2001
    ....
  99. ncbi Activation of protein kinase C increases acetylcholine release from frog motor nerves by a direct action on L-type Ca(2+) channels and apparently not by depolarisation of the terminal
    M S Arenson
    Section of Molecular Pharmacology, Division of Biomedical Sciences, School of Medicine and Dentistry, Queen Mary and Westfield College, University of London, Mile End Road, London E1 4NS, UK
    Neuroscience 104:1157-64. 2001
    ....
  100. ncbi Facile entry to the tetracyclic 5-7-6-3 tigliane ring system
    T V Ovaska
    Department of Chemistry, Connecticut College, 270 Mohegan Avenue, New London, Connecticut 06320, USA
    Org Lett 3:115-7. 2001
    ..The synthesis was conducted using readily available nonracemic starting materials to provide the target structure as a single enantiomer in high chemical yield...
  101. ncbi Regulation of [3H]phorbol-12,13-dibutyrate binding sites in mouse neuroblastoma cells: simultaneous down-regulation by phorbol esters and desensitization of their inhibition of muscarinic receptor function
    W S Lai
    Department of Pharmacology and Toxicology, School of Pharmacy, University of Maryland, Baltimore
    J Pharmacol Exp Ther 244:41-50. 1988
    ....

Research Grants5

  1. TUMOR CYTOLYSIS BY MONONUCLEAR LEUKOCYTES
    Dorothea Zucker Franklin; Fiscal Year: 1990
    ..g., by treatment with phorbols. Comparable target cells and their isolated membranes will be subjected to biochemical, histochemical, ..
  2. New Synthetic Routes to Phorbols and Ingananes
    TIMO OVASKA; Fiscal Year: 2003
    ..This basic ring construction strategy will be coupled with other synthetic methodologies to generate structurally and functionally diverse analogues of phorbol and ingenol. ..
  3. SYNTHETIC STUDIES RELATED TO CANCER RESEARCH/TREATMENT
    Paul Wender; Fiscal Year: 2005
    ..Overall, this research program is expected to be of significant value in chemistry, biology, and medicine. ..
  4. Cellular Regulation of Salt Taste Transduction
    Vijay Lyall; Fiscal Year: 2008
    ..The identification of natural and synthetic analogues similar to cetylpyridinium chloride that modulate the non-specific cation receptor channel may be potentially useful as salt taste enhancers or suppressers. ..
  5. PHYSICOCHEMICAL INVESTIGATION OF TASTE
    Vijay Lyall; Fiscal Year: 2010
    ..The research will reveal how the sour taste defense mechanism functions to prevent the ingestion of acids. ..