clerodane diterpenes

Summary

Summary: A group of DITERPENES cyclized into 2-rings with a side-chain.

Top Publications

  1. ncbi Cytotoxic clerodane diterpenes from Glossocarya calcicola
    Heidi L Rasikari
    Centre for Phytochemistry and Pharmacology, Southern Cross University, Military Rd, Level 2, Lismore, N S W 2780, Australia
    Phytochemistry 66:2844-50. 2005
  2. pmc Synthetic studies of neoclerodane diterpenes from Salvia divinorum: semisynthesis of salvinicins A and B and other chemical transformations of salvinorin A
    Wayne W Harding
    Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, Iowa 52242, USA
    J Nat Prod 69:107-12. 2006
  3. ncbi Neo-clerodane diterpenes from Teucrium fruticans
    Josep Coll
    Instituto de Investigaciones Quimicas y Ambientales de Barcelona Josep Pascual Vila, Consejo Superior de Investigaciones Cientificas, Jordi Girona 18 26, 08034 Barcelona, Spain
    Phytochemistry 65:387-92. 2004
  4. ncbi NMR shift data of neo-clerodane diterpenes from the genus Ajuga
    Josep Coll
    Institut d Investigacions Químiques i Ambientals de Barcelona Josep Pascual Vila, CSIC, Barcelona 08034, Spain
    Phytochem Anal 13:372-80. 2002
  5. ncbi Clerodane diterpenes from Baccharis sagittalis: insect antifeedant activity
    Diego A Cifuente
    INTEQUI CONICET Facultad de Química, Bioquimica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera 5700 San Luis, Argentina
    Phytochemistry 61:899-905. 2002
  6. ncbi Aporphine alkaloids, clerodane diterpenes, and other constituents from Tinospora cordifolia
    Van Kiem Phan
    Laboratory of Organic Chemistry, Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam
    Fitoterapia 81:485-9. 2010
  7. ncbi New bioactive clerodane diterpenoids from the bark of Casearia grewiifolia
    Somdej Kanokmedhakul
    Department of Chemistry, Applied Taxonomic Research Center, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand
    J Nat Prod 68:183-8. 2005
  8. ncbi Structure and absolute configuration of clerodane diterpene glycosides and a rearranged cadinane sesquiterpene glycoside from the stems of Tinospora sinensis
    Wei Li
    Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, Japan
    J Nat Prod 70:1971-6. 2007
  9. ncbi Dehydrocrotonin and its derivative, dimethylamide-crotonin induce apoptosis with lipid peroxidation and activation of caspases-2, -6 and -9 in human leukemic cells HL60
    Maristella C Anazetti
    Departamento de Bioquimica, Instituto de Biologia, Universidade Estadual de Campinas, CP 6109, SP, 13083 970, Brazil
    Toxicology 203:123-37. 2004
  10. ncbi New cytotoxic clerodane diterpenoids from the leaves and twigs of Casearia membranacea
    Ya Ching Shen
    Institute of Marine Resources, National Sun Yat Sen University, 70 Lien Hai Road, Kaohsiung, Taiwan, Republic of China
    J Nat Prod 67:316-21. 2004

Research Grants

Detail Information

Publications173 found, 100 shown here

  1. ncbi Cytotoxic clerodane diterpenes from Glossocarya calcicola
    Heidi L Rasikari
    Centre for Phytochemistry and Pharmacology, Southern Cross University, Military Rd, Level 2, Lismore, N S W 2780, Australia
    Phytochemistry 66:2844-50. 2005
    Three clerodane diterpenes were isolated and identified from leaf extract of Glossocarya calcicola...
  2. pmc Synthetic studies of neoclerodane diterpenes from Salvia divinorum: semisynthesis of salvinicins A and B and other chemical transformations of salvinorin A
    Wayne W Harding
    Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, Iowa 52242, USA
    J Nat Prod 69:107-12. 2006
    ..divinorum. In particular, this work provides a semisynthesis of salvinicins A (2) and B (3) and has identified 10a as the first neoclerodane diterpene with delta opioid antagonist activity...
  3. ncbi Neo-clerodane diterpenes from Teucrium fruticans
    Josep Coll
    Instituto de Investigaciones Quimicas y Ambientales de Barcelona Josep Pascual Vila, Consejo Superior de Investigaciones Cientificas, Jordi Girona 18 26, 08034 Barcelona, Spain
    Phytochemistry 65:387-92. 2004
    ..Semi-prep-HPLC proved to be a convenient purification procedure, occasionally being followed by TLC. The new compounds were assayed against Spodoptera littoralis and two of them were shown to have potent antifeedant activity...
  4. ncbi NMR shift data of neo-clerodane diterpenes from the genus Ajuga
    Josep Coll
    Institut d Investigacions Químiques i Ambientals de Barcelona Josep Pascual Vila, CSIC, Barcelona 08034, Spain
    Phytochem Anal 13:372-80. 2002
    ....
  5. ncbi Clerodane diterpenes from Baccharis sagittalis: insect antifeedant activity
    Diego A Cifuente
    INTEQUI CONICET Facultad de Química, Bioquimica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera 5700 San Luis, Argentina
    Phytochemistry 61:899-905. 2002
    ..Antifeedant activity toward Tenebrio molitor larvae of the isolated compounds along with six other diterpenes was evaluated and some structure-antifeedant bioactivity relationships are reported...
  6. ncbi Aporphine alkaloids, clerodane diterpenes, and other constituents from Tinospora cordifolia
    Van Kiem Phan
    Laboratory of Organic Chemistry, Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam
    Fitoterapia 81:485-9. 2010
    ....
  7. ncbi New bioactive clerodane diterpenoids from the bark of Casearia grewiifolia
    Somdej Kanokmedhakul
    Department of Chemistry, Applied Taxonomic Research Center, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand
    J Nat Prod 68:183-8. 2005
    ..fractionation of hexane and dichloromethane extracts of the bark of Casearia grewiifolia afforded four new clerodane diterpenes, caseargrewiins A-D (1-4), and two known clerodane diterpenes, rel-(2S,5R,6R,8S,9S,10R,18S,19R)-18,19-..
  8. ncbi Structure and absolute configuration of clerodane diterpene glycosides and a rearranged cadinane sesquiterpene glycoside from the stems of Tinospora sinensis
    Wei Li
    Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, Japan
    J Nat Prod 70:1971-6. 2007
    ..The absolute configuration was determined by application of the modified Mosher's method and chemical transformation. The inhibitory activities of the isolated compounds against alpha-glucosidase are also described...
  9. ncbi Dehydrocrotonin and its derivative, dimethylamide-crotonin induce apoptosis with lipid peroxidation and activation of caspases-2, -6 and -9 in human leukemic cells HL60
    Maristella C Anazetti
    Departamento de Bioquimica, Instituto de Biologia, Universidade Estadual de Campinas, CP 6109, SP, 13083 970, Brazil
    Toxicology 203:123-37. 2004
    ....
  10. ncbi New cytotoxic clerodane diterpenoids from the leaves and twigs of Casearia membranacea
    Ya Ching Shen
    Institute of Marine Resources, National Sun Yat Sen University, 70 Lien Hai Road, Kaohsiung, Taiwan, Republic of China
    J Nat Prod 67:316-21. 2004
    ..fractionation of an EtOAc-soluble extract of Casearia membranacea has resulted in the isolation of six new clerodane diterpenes, caseamembrins A-F (1-6), and a known compound, rel-(2S,5R,6R,8S,9S,10R,18S,19R)-diacetoxy-18,19-epoxy-6-..
  11. pmc Synthetic studies of neoclerodane diterpenes from Salvia divinorum: exploration of the 1-position
    Kenneth G Holden
    Holden Laboratories, Carmel, CA 93923, USA
    Bioorg Med Chem Lett 17:6111-5. 2007
    ..These observations suggest that the ketone of 2b is a key structural feature responsible for mu agonist activity...
  12. ncbi Two new cytotoxic clerodane diterpenoids from Casearia membranacea
    Ya Ching Shen
    Institute of Marine Resources, National Sun Yat Sen University, 70 Lien Hai Road, Kaohsiung, Taiwan, Republic of China
    Chem Pharm Bull (Tokyo) 52:108-10. 2004
    In addition to casearlucin A (3), two new clerodane diterpenes, caseamembrols A (1) and B (2) have been isolated from the leaves and twigs of Casearia membranacea by bioassay-guided fractionation...
  13. ncbi Divinatorins A-C, new neoclerodane diterpenoids from the controlled sage Salvia divinorum
    Andrea K Bigham
    Department of Microbiology and Immunology, School of Chemistry, The University of Melbourne, Victoria, 3010, Australia
    J Nat Prod 66:1242-4. 2003
    ..Neither the crude extract nor 7-9 displayed antimicrobial activity...
  14. ncbi Comparison of the gastroprotective effect of a diterpene lactone isolated from Croton cajucara with its synthetic derivatives
    Patricia Silva Melo
    Departamento de Bioquimica, Instituto de Biologia, Universidade Estadual de Campinas, CP 6110, CEP 13081 970, SP, Campinas, Brazil
    J Ethnopharmacol 87:169-74. 2003
    ..o.), was more effective. The presence of a lactone moiety or Michael acceptor is probably essential for the anti-ulcerogenic effect of these compounds...
  15. ncbi Influence of protein phosphatase inhibitors on HL60 cells death induction by dehydrocrotonin
    Ana Claudia Galvão Freire
    Department of Biochemistry, Institute of Biology, State University of Campinas UNICAMP, CP 6109, 13083 970, Sao Paulo, Campinas, Brazil
    Leuk Res 27:823-9. 2003
    ..Therefore, this differentiation pathway involves the modulation of protein phosphatases and this inhibition promotes the t-DCTN action on apoptosis induction...
  16. ncbi Three new cholinesterase-inhibiting cis-clerodane diterpenoids from Otostegia limbata
    Viqar Uddin Ahmad
    International Center for Chemical Sciences, H E J Research Institute of Chemistry, University of Karachi, Pakistan
    Chem Pharm Bull (Tokyo) 53:378-81. 2005
    ..Compounds 1-3 displayed inhibitory potential in a concentration-dependent manner against acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BChE; EC 3.1.1.8) enzymes, respectively...
  17. pmc Salvinicins A and B, new neoclerodane diterpenes from Salvia divinorum
    Wayne W Harding
    Division of Medicinal and Natural Products Chemistry, The University of Iowa, Iowa City, 52242, USA
    Org Lett 7:3017-20. 2005
    ..The absolute stereochemistry of these compounds was assigned on the basis of single-crystal X-ray crystallographic analysis of salvinicin A (4) and a 3,4-dichlorobenzoate derivative of salvinorin B...
  18. ncbi Gaudichanolides A and B, clerodane diterpenes from Baccharis gaudichaudiana
    Ken ichiro Hayashi
    Department of Biochemistry, Okayama University of Science, 1 1 Ridai cho, Okayama City, 700 0005 Japan
    J Nat Prod 68:1121-4. 2005
    ..The structures and relative stereochemistry of 1 and 2 were elucidated by detailed 2D NMR spectroscopic experiments, and the absolute stereochemistry of 1 was determined by X-ray crystallographic analysis...
  19. ncbi Bioactive ent-clerodane diterpenoids from Scutellaria barbata
    Sheng Jun Dai
    School of Pharmaceutical Science, Yantai University, Yantai, People s Republic of China
    Planta Med 73:1217-20. 2007
    ..1-7.2 microM...
  20. ncbi Complete (1)H and (13)C NMR assignments of two new trans-clerodane diterpenoids from Otostegia limbata
    Umar Farooq
    Department of Environmental Sciences, COMSATS Institute of Information Technology, Abbottabad, Pakistan
    Magn Reson Chem 45:766-9. 2007
    ..The structure assignments are based on (1)H and (13)C NMR spectra, 2D NMR (HMQC, HMBC, COSY, NOESY and NOE) techniques and comparison with the literature data...
  21. ncbi Isolation and chemical modification of clerodane diterpenoids from Salvia species as potential agonists at the kappa-opioid receptor
    Yiqiang Li
    Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7AY, UK
    Chem Biodivers 4:1586-93. 2007
    ..Our experiments demonstrate that the relatively well-accessible diterpenoid 6 could be used as starting material for future studies into the structure-activity relationship at the kappa-opioid receptor...
  22. pmc Cytotoxic clerodane diterpenoids and their hydrolysis products from Casearia nigrescens from the rainforest of Madagascar
    Russell B Williams
    Department of Chemistry, M C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 0212, USA
    J Nat Prod 70:206-9. 2007
    ..The structures of compounds 1-4 were determined using 1D and 2D NMR spectroscopy. All four compounds showed moderate cytotoxicity to the A2780 human ovarian cancer cell line, with an IC50 range of 0.83-1.4 microM...
  23. ncbi Protective effect of DCTN (trans-dehydrocrotonin) against induction of micronuclei and apoptosis by different mutagenic agents in vitro
    Aline Poersch
    Departamento de Biologia Geral, CCB, Centro de Ciencias Biologicas, Universidade Estadual de Londrina UEL, Campus Universitario, CEP 86051 970 Londrina PR, Brazil
    Mutat Res 629:14-23. 2007
    ..These results together with findings reported for DCTN in vivo, support the indication of this active principle at these concentrations for therapeutic use...
  24. ncbi New clerodane diterpenoids from the aerial parts of Pulicaria wightiana
    Biswanath Das
    Organic Chemistry Division I, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Chem Biodivers 3:175-9. 2006
    ..Their structures were established based on spectroscopic data, and their antibacterial activities were evaluated (Table 2)...
  25. ncbi Neo-clerodane diterpenes from the hallucinogenic sage Salvia divinorum
    Osamu Shirota
    Laboratory of Pharmacognosy and Natural Product Chemistry, Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, 1314 1 Shido, Sanuki City, Kagawa 769 2193, Japan
    J Nat Prod 69:1782-6. 2006
    Seven new neo-clerodane diterpenes, salvidivins A (2), B, (3), C (4), and D (5), salvinorins H (6) and I (7), and divinatorin [corrected] F (8), along with eight known neo-clerodane diterpenes, salvinorins A (1)-F, divinatorins A and B, ..
  26. ncbi Two new neo-clerodane diterpenoids from Scutellaria barbata
    Sheng Jun Dai
    School of Pharmaceutical Science, Yantai University, Yantai 264005, China
    J Integr Plant Biol 50:699-702. 2008
    ..5-6.7 microM...
  27. ncbi Clerodane and labdane diterpenoids from Nuxia sphaerocephala
    Lengo Mambu
    USM 0502 UMR5154 CNRS Chimie et Biochimie des substances naturelles, Departement Regulations, Developpement, Diversité Moléculaire, Museum national d histoire naturelle, 63 rue Buffon, 75231 Paris Cedex 05, France
    Phytochemistry 67:444-51. 2006
    ..The structure and the relative stereochemistry of the compounds were established on the basis of their spectroscopic properties. The absolute configuration at C-13 of 1 and 5 was determined by the PGME amide procedure...
  28. ncbi Cytotoxic clerodane diterpenoids from Casearia membranacea
    Ya Ching Shen
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 68:1665-8. 2005
    ..fractionation of the EtOAc extract of Casearia membranacea leaves and twigs afforded three new clerodane diterpenes, caseamembrins M-O (1-3), and the known rel-(2S,5R,6R,8S,9S,10R,18S,19R)-2-(2-methylbutyryloxy)-6-hydroxy-..
  29. ncbi Comparative cytotoxicity of dimethylamide-crotonin in the promyelocytic leukemia cell line (HL60) and human peripheral blood mononuclear cells
    Maristella Conte Anazetti
    Departamento de Bioqui mica, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, CP 6109, Campinas, SP, 13083 970, Brazil
    Toxicology 188:261-74. 2003
    ..Thus, DCR and DHC inhibit HL60 cell growth in vitro partly by inducing apoptosis and cell differentiation, but does not cause serious damage to immune cells according to our experimental conditions...
  30. ncbi Cytotoxic effect of the diterpene lactone dehydrocrotonin from Croton cajucara on human promyelocytic leukemia cells
    Ana Claudia Galvão Freire
    Planta Med 69:67-9. 2003
    ..According to the chemical characteristics of both compounds, the cytotoxic effect of t-DCTN could be explained through two mechanisms: adduct formation with DNA and proteins and/or oxidative stress induction...
  31. ncbi Derivatives of dehydrocrotonin, a diterpene lactone isolated from Croton cajucara: cytotoxicity in rat cultured hepatocytes and in V79 cells
    P S Melo
    Departamento de Bioquimica, Instituto de Biologia, Universidade Estadual de Campinas, SP, Brazil
    Hum Exp Toxicol 21:281-8. 2002
    ..Thus, aging reduced the cytotoxic effects of DHC derivatives in isolated hepatocytes, suggesting that P450-mediated biotransformation of such derivatives may lead to the formation of more toxic metabolites...
  32. ncbi Antifeedant activity of metabolites from Viguiera tucumanensis
    Clarisa E Vaccarini
    Departamento de Quimica Organica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Instituto Multidisciplinario de Biología Vegetal IMBIV CONICET UNC, Argentina
    Nat Prod Lett 16:323-7. 2002
    ..tucumanensis, were isolated and bioassayed. The clerodane 1 showed higher antifeedant activity than other related compounds. Structure-activity relationships are also discussed...
  33. ncbi Clerodane and labdane diterpene glycosides from a Malagasy endemic plant, Cussonia racemosa
    R R Harinantenaina Liva
    Institute of Pharmaceutical Sciences, Faculty of Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Phytochemistry 60:339-43. 2002
    ..The structures of the compounds were deduced on the basis of their physical and spectral data...
  34. ncbi Natural trans-crotonin: the antiulcerogenic effect of another diterpene isolated from the bark of Croton cajucara Benth
    Clelia Akiko Hiruma-Lima
    Departamento de Fisiologia, Instituto de Biociencias, Universidade Estadual Paulista, Botucatu, Sao Paulo, Brazil
    Biol Pharm Bull 25:452-6. 2002
    ..In light of results obtained with DHC and natural trans-crotonin in the present study, we concluded that the A-ring of both diterpenes is not directly involved in the antiulcerogenic activity...
  35. ncbi Constituents of Burasaïa madagascarensis: a new clerodane-type diterpene
    Lengo Mambu
    Planta Med 68:377-9. 2002
    ..The structures were established by the interpretation of the spectral data. All the described compounds exhibited weak antimalarial activity...
  36. ncbi Croblongifolin, a new anticancer clerodane from Croton oblongifolius
    Sophon Roengsumran
    Planta Med 68:274-7. 2002
    ..Structures were established based on spectroscopic and X-ray analysis. Croblongifolin showed a significant cytotoxicity against various human tumor cell lines including HEP-G2, SW620, CHAGO, KATO3 and BT474...
  37. ncbi Blood glucose- and triglyceride-lowering effect of trans-dehydrocrotonin, a diterpene from Croton cajucara Benth., in rats
    R M Silva
    Department of Physiology and Pharmacology, Faculty of Medicine, , Fortaleza, Brazil
    Diabetes Obes Metab 3:452-6. 2001
    ..CONCLUSION: The results suggest that t-DCTN has an antidiabetic potential that warrants further research on its mechanism and clinical significance...
  38. ncbi Antitumor agents. Part 212. Bucidarasins A-C, three new cytotoxic clerodane diterpenes from Bucida buceras
    Ken ichiro Hayashi
    Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA
    Bioorg Med Chem Lett 12:345-8. 2002
    As part of a study on antitumor agents from rainforest plants, four new clerodane diterpenes, bucidarasins A--D (1-4), were isolated from Bucida buceras. Their structures were elucidated from detailed 2D NMR analyses...
  39. ncbi Ethnopharmacology, phytochemistry and pharmacology: a successful combination in the study of Croton cajucara
    M A Maciel
    Instituto de Quimica, Universidade Federal de Rio de Janeiro, Centro de Tecnologia, Bloco A SALA 621 Cidade Universitária, CEP 21945 970, Rio de Janeiro, Brazil
    J Ethnopharmacol 70:41-55. 2000
    ..The biological experiments, using the plant extracts and the terpenoids DCTN, CTN and AAA, are herein discussed...
  40. ncbi Ethnopharmacology of the plants of genus Ajuga
    Zafar H Israili
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Pak J Pharm Sci 22:425-62. 2009
    ..Thus, genus Ajuga has significant medicinal and economic importance...
  41. ncbi Search for antifungal and anticancer compounds from native plant species of Cerrado and Atlantic Forest
    V da S Bolzani
    Instituto de Quimica, Universidade Estadual Paulista, Araraquara, SP
    An Acad Bras Cienc 71:181-7. 1999
    ..sylvestris, a medicinal plant species found in Cerrado and Atlantic Forest, led to the isolation of clerodane diterpenes 12-13 which showed effect on DNA...
  42. ncbi Antimicrobial activity of various parts of Polyalthia longifolia var. pendula: isolation of active principles from the leaves and the berries
    Shaheen Faizi
    International Center for Chemical and Biological Sciences, H E J Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Phytother Res 22:907-12. 2008
    ..The acetyl derivative (10) of 1 and the methyl derivative (3) of 2 were found to be less active than the parent compounds. A complex of allantoin was also obtained from the berries, which on hydrolysis furnished pure allantoin (11)...
  43. ncbi Phytotoxic clerodane diterpenes from Salvia miniata Fernald (Lamiaceae)
    Angela Bisio
    Dipartimento di Chimica e Tecnologie Farmaceutiche e Alimentari, Universita di Genova, Genova, Italy
    Phytochemistry 72:265-75. 2011
    ..and Avena sativa L. in Petri dish experiments. Parallel results have been obtained in experiments carried out to evaluate the subsequent growth of the seedlings of the target species in the presence of the tested compounds...
  44. ncbi Structure- and species-dependent insecticidal effects of neo-clerodane diterpenes
    A Gonzalez-Coloma
    Centro de Ciencias Medioambientales, CSIC, Madrid, Spain
    J Agric Food Chem 48:3677-81. 2000
    ..Furthermore, the presence of a 4,18-epoxy/diol moiety was an important feature for both the antifeedant and the toxic/postingestive effects...
  45. ncbi Cytotoxic clerodane diterpenes from Casearia rupestris
    Gerardo M Vieira-Júnior
    Institute of Chemistry, Nucley of Bioassay, Biosynthesis and Ecophysiology of Natural Products NuBBE, Sao Paulo State University, UNESP, C P 14801 970, Araraquara, SP, Brazil
    J Nat Prod 74:776-81. 2011
    Four new clerodane diterpenes, casearupestrins A-D (1-4), were isolated from the leaves of Casearia rupestris. Compounds 1 and 4 were acetylated to yield 2,7-di-O-acetylcasearupestrin A (5) and 2,6-di-O-acetylcasearupestrin D (6)...
  46. ncbi Three clerodane diterpenoids from Croton eluteria Bennett
    C Vigor
    Laboratoire Pharmacophores Redox, Phytochimie et Radiobiologie, Faculte des sciences pharmaceutiques, 35 chemin des Maraichers, F 31062, Toulouse, France
    Phytochemistry 57:1209-12. 2001
    ....
  47. ncbi Antibacterial clerodane diterpenes from Goldenrod (Solidago virgaurea)
    Courtney M Starks
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences Inc, 1912 Innerbelt Business Center Drive, St Louis, MO 63114, USA
    Phytochemistry 71:104-9. 2010
    Nine clerodane diterpenes, solidagoic acids C-I (1-7), cleroda-3,13(14)-dien-16,15:18,19-diolide (8) and cleroda-3,13(14)-dien-15,16:18,19-diolide (9) were isolated and characterised from the ethanol-ethyl acetate (1:1) extract of ..
  48. ncbi Diterpenoids
    James R Hanson
    Department of Chemistry, University of Sussex, Brighton, Sussex BN1 9QJ, UK
    Nat Prod Rep 24:1332-41. 2007
    ..This review covers the isolation and structures of diterpenoids including labdanes, clerodanes, pimaranes, abietanes, kauranes, cembranes, taxanes and marine diterpenoids; 173 references are cited...
  49. ncbi Palmadorins A--C, diterpene glycerides from the antarctic nudibranch Austrodoris kerguelenensis
    Thushara Diyabalanage
    Department of Chemistry and Center for Molecular Diversity in Drug Design, Discovery and Delivery, University of South Florida, Tampa, Florida 33620, USA
    J Nat Prod 73:416-21. 2010
    ..has revealed additional examples, palmadorins A-C (1-3), as the first three members of a new series of clerodane diterpenes. In this paper we describe their isolation, structure elucidation, and stereochemical analysis using a ..
  50. ncbi Diterpenoids from Casearia sylvestris
    Wei Wang
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, Oxford, MS 38677, USA
    Planta Med 75:1436-41. 2009
    Two highly oxygenated clerodane diterpenes casearins U (1) and V (2) and two ent-kaurane diterpene glucosides sylvestrisides A (3) and B (4) were isolated from the leaves of Casearia sylvestris, together with 13 known compounds...
  51. ncbi Antiulcerogenic effect and cytotoxic activity of semi-synthetic crotonin obtained from Croton cajucara Benth
    Ana Beatriz Albino de Almeida
    Departamento de Farmacologia, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Campinas, SP, Brazil
    Eur J Pharmacol 472:205-12. 2003
    ..Our data also show that semi-synthetic crotonin was less toxic than dehydrocrotonin and that the cytotoxic effects decreases with the time that isolated hepatocytes were in culture...
  52. pmc Pharmacokinetics of the potent hallucinogen, salvinorin A in primates parallels the rapid onset and short duration of effects in humans
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroimage 41:1044-50. 2008
    ..divinorum when smoked. The effects of salvinorin A may occur at <10 mug in the human brain, emphasizing its remarkable potency...
  53. ncbi Cytotoxicity of derivatives from dehydrocrotonin on V79 cells and Escherichia coli
    P da Silva Melo
    Department of Biochemistry, Institute of Biology, State University of Campinas UNICAMP, CP 6110, Campinas SP 13083 970, Brazil
    Toxicology 159:135-41. 2001
    ..The three compounds were less toxic on V79 cells than DHC. DHC, compounds II, III and IV did not change the respiration rate of Escherichia coli on the acute toxicity assay...
  54. ncbi 5,10-seco-neo-clerodanes and neo-clerodanes from Salvia microphylla
    Elihú Bautista
    Instituto de Quimica, Universidad Nacional Autonoma de Mexico, Circuito Exterior, Ciudad Universitaria, Coyoacan 04510, Mexico City, Mexico
    J Nat Prod 77:1088-92. 2014
    ..The relative configurations of the salvimicrophyllins were determined by analysis of NOESY spectra and ECD curves, and the relative configuration of compound 2 was confirmed by single-crystal X-ray diffraction crystallography. ..
  55. ncbi Antileishmanial activity of natural diterpenes from Cistus sp. and semisynthetic derivatives thereof
    Nikolas Fokialakis
    Natural Products Utilization Research Unit, USDA ARS, University of Mississippi, USA
    Biol Pharm Bull 29:1775-8. 2006
    Eleven cis-clerodane diterpenes, seven labdane type diterpenes and one triterpene isolated from Cistus monspeliensis and the resin "Ladano" of Cistus creticus subsp...
  56. ncbi Cytotoxic clerodane diterpenes from Zuelania guidonia
    Carlos Calderon
    Escuela de Quimica and CIPRONA, Universidad de Costa Rica, 2060 San Jose, Costa Rica
    J Nat Prod 77:455-63. 2014
    The leaves of Zuelania guidonia yielded eight new clerodane diterpenes, namely, zuelaguidins A-H (1-8), and the known clerodane diterpene esculentin A (9). Some of these structures contained a 3,6-dihydro-1,2-dioxin moiety...
  57. ncbi Efficient construction of the clerodane decalin core by an asymmetric Morita-Baylis-Hillman reaction/Lewis acid promoted annulation strategy
    Stacy A Rodgen
    Department of Chemistry, Metcalf Center for Science and Engineering, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA
    Angew Chem Int Ed Engl 45:4929-32. 2006
  58. ncbi Clerodane diterpenes from Tinospora rumphii
    C Y Ragasa
    Chemistry Department, De La Salle University, Manila, Philippines
    J Nat Prod 63:509-11. 2000
    ..Two new diterpenes (1 and 2) were obtained from the leaves of Tinospora rumphii, along with the known compounds tinotufolin D and vitexilactone. The structures of compounds 1 and 2 were established on the basis of spectroscopic studies...
  59. ncbi Insect antifeedant activity of clerodane diterpenes and related model compounds
    Edwin A Klein Gebbinck
    SelAct B V, Nijenborgh 4, 9747 AG, Groningen, The Netherlands
    Phytochemistry 61:737-70. 2002
    A comprehensive compilation of all test results on the insect antifeedant activity of clerodane diterpenes and related model compounds is reported...
  60. ncbi Total synthesis of the hallucinogenic neoclerodane diterpenoid salvinorin A
    Masato Nozawa
    Graduate School of Science and Technology, Niigata University, 8050, 2 Nocho, Ikarashi, Nishi ku, Niigata 950 2181, Japan
    Org Lett 10:1365-8. 2008
    ....
  61. ncbi American Chemical Society--233rd National Meeting. CNS, cancer and cardiovascular targets. 25-29 March 2007, Chicago, IL, USA
    David Rotella
    Wyeth Research, Princeton, NJ 08543, USA
    IDrugs 10:310-2. 2007
  62. ncbi Toward a structure-based model of salvinorin A recognition of the kappa-opioid receptor
    Brian E Kane
    Department of Medicinal Chemistry and Center for Drug Design, University of Minnesota, Minneapolis, MN 55455, USA
    J Med Chem 51:1824-30. 2008
    ..The model explains the role that hydrophobic contacts play in binding this lipophilic ligand and gives insight into the structural basis to the mu-opioid receptor selectivity of 2'-benzoyl salvinorin (herkinorin)...
  63. ncbi Diterpenoids of terrestrial origin
    James R Hanson
    University of Sussex, Department of Chemistry, Brighton, Sussex, UK
    Nat Prod Rep 32:76-87. 2014
    ..There are 179 references. ..
  64. pmc 2-Methoxymethyl-salvinorin B is a potent kappa opioid receptor agonist with longer lasting action in vivo than salvinorin A
    Yulin Wang
    Department of Pharmacology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, PA 19140, USA
    J Pharmacol Exp Ther 324:1073-83. 2008
    ..Sal A at 10 mg/kg elicited neither antinociception nor hypothermia 30 min after administration to rats. In summary, MOM-Sal B is a potent and efficacious KOPR agonist with longer lasting in vivo effects than Sal A...
  65. ncbi Bioactive clerodane diterpenes from roots of Carex distachya
    Antonio Fiorentino
    Dipartimento di Scienze della Vita, Laboratorio di Fitochimica, Seconda Universita degli Studi di Napoli, Via Vivaldi 43, 81100 Caserta, Italy
    Nat Prod Commun 5:1539-42. 2010
    Two new clerodane diterpenes were isolated from roots of Carex distachya Desf., a perennial plant widely distributed in the coastal area of the Mediterranean basin...
  66. pmc Effects of acute and repeated administration of salvinorin A on dopamine function in the rat dorsal striatum
    Brenda J Gehrke
    Integrative Neuroscience Section, NIH NIDA Intramural Research Program, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 197:509-17. 2008
    ..Acute systemic administration of salvinorin A, a naturally occurring kappa-opioid receptor (KOPr) agonist, decreases locomotion and striatal dopamine (DA) overflow...
  67. ncbi Salvia divinorum and salvinorin A: an update on pharmacology and analytical methodology
    Oliver Grundmann
    College of Pharmacy, Department of Pharmaceutics, University of Florida, FL 32608, USA
    Planta Med 73:1039-46. 2007
    ..divinorum...
  68. ncbi Synthetic studies of neoclerodane diterpenes from Salvia divinorum: preparation and opioid receptor activity of salvinicin analogues
    Denise S Simpson
    Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, Iowa 52242, USA
    J Med Chem 50:3596-603. 2007
    ..This indicates that additional structural modifications of 1a may lead to analogues with higher potency and utility as drug abuse medications...
  69. pmc Biosynthesis of salvinorin A proceeds via the deoxyxylulose phosphate pathway
    Lukasz Kutrzeba
    Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, MS 38677 1848, USA
    Phytochemistry 68:1872-81. 2007
    ....
  70. ncbi Cornutins C-L, neo-clerodane-type diterpenoids from Cornutia grandifolia var. intermedia
    Kristina Jenett-Siems
    Institut für Pharmazie Pharmazeutische Biologie, Freie Universitat Berlin, Konigin Luise Str 2 4, D 14195, Berlin, Germany
    Phytochemistry 64:797-804. 2003
    ..intermedia. Their structures have been elucidated by detailed spectroscopic analysis. In addition, the in vitro antiplasmodial activity of four isolated compounds (cornutin C-F) has been evaluated, revealing only a marginal activity...
  71. ncbi Two new neo-clerodane diterpenoid alkaloids from Scutellaria barbata with cytotoxic activities
    Sheng Jun Dai
    School of Pharmaceutical Science, Yantai University, Yantai, China
    J Asian Nat Prod Res 11:451-6. 2009
    ..1-5.7 microM...
  72. ncbi Two new diterpenoids from Ballota limbata
    Viqar Uddin Ahmad
    International Center for Chemical Sciences, H E J Research Institute of Chemistry, University of Karachi, Pakistan
    Chem Pharm Bull (Tokyo) 52:441-3. 2004
    ..Compounds 1 and 2 displayed inhibitory potential against lipoxygenase enzyme in a concentration-dependent fashion with IC(50) values of 99.6 microM and 38.3 microM, respectively...
  73. pmc Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist
    Bryan L Roth
    National Institute of Mental Health Psychoactive Drug Screening Program and Department of Biochemistry, Case Western Reserve University Medical School, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 99:11934-9. 2002
    ..g., schizophrenia, dementia, and bipolar disorders). Additionally, these results suggest that kappa opioid receptors play a prominent role in the modulation of human perception...
  74. ncbi LC-MS-SPE-NMR for the isolation and characterization of neo-clerodane diterpenoids from Teucrium luteum subsp. flavovirens (perpendicular)
    Amaya Castro
    Institut de Quimica Avancada de Catalunya, Consejo Superior de Investigaciones Cientificas, Barcelona, Spain
    J Nat Prod 73:962-5. 2010
    neo-Clerodane diterpenes of plant origin are molecules difficult to monitor due to their nonspecific UV/vis absorption...
  75. ncbi The plant-derived hallucinogen, salvinorin A, produces kappa-opioid agonist-like discriminative effects in rhesus monkeys
    Eduardo R Butelman
    The Rockefeller University, 1230 York Avenue, Box 171, New York, NY 10021, USA
    Psychopharmacology (Berl) 172:220-4. 2004
    ..It was postulated that salvinorin A would produce discriminative stimulus effects similar to those of a high efficacy kappa-agonist (U69,593) in rhesus monkeys...
  76. ncbi Neoclerodanes from Teucrium orientale
    Maurizio Bruno
    Dipartimento di Chimica Organica E Paterno, Universita di Palermo, Viale delle Scienze, Parco D Orleans II, Palermo, Italy
    Chem Pharm Bull (Tokyo) 52:1497-500. 2004
    ..Compounds 1-3 were assayed for antifeedant activity against Spodoptera littoralis, S. frugiperda and Heliocoverpa armigera. Teucrolivin A was the most potent of the three compounds tested...
  77. ncbi Receptorome screening: a powerful, facile approach to better understand and engineer drugs
    Vincent Setola
    Department of Pharmacology of the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Drug News Perspect 22:459-66. 2009
    ....
  78. ncbi Constituents of Polyalthia longifolia var. pendula
    Tzong Huei Lee
    College of Pharmacy, Taipei Medical University, Taipei, Taiwan 110, Republic of China
    J Nat Prod 72:1960-3. 2009
    ..Compounds were evaluated for their antiproliferative activities against A549 and MCF-7 cancer cells, and among the substances tested, only 16-oxo-cleroda-3,13-dien-15-oic acid (8) exhibited cytotoxicity...
  79. ncbi Bioactive neo-clerodane diterpenoids from the whole plants of Ajuga ciliata Bunge
    Ping Guo
    College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, People s Republic of China
    J Nat Prod 74:1575-83. 2011
    Ten new neo-clerodane diterpenes, ajugaciliatins A-J (1-5, 8-12), along with 17 known analogues (6, 7, 13-27) were isolated from the whole plants of Ajuga ciliata Bunge...
  80. ncbi Chemical composition and antioxidant activity of Algerian propolis
    Anna Lisa Piccinelli
    Dipartimento di Farmacia, University of Salerno, Via Ponte Don Melillo, 84084 Fisciano, Italy
    J Agric Food Chem 61:5080-8. 2013
    ..caffeate esters and flavonoids from an AP type rich in phenolic compounds (PAP) and labdane and clerodane diterpenes, together with a polymethoxyflavonol, from an AP type containing mainly diterpenes (DAP)...
  81. ncbi New phytoconstituents from the stem bark of Tinospora cordifolia Miers
    Faheem Ahmad
    Phytochemistry Research Laboratory, Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India
    Nat Prod Res 24:926-34. 2010
    ....
  82. ncbi Diterpenoids of terrestrial origin
    James R Hanson
    Department of Chemistry, University of Surrey, Brighton, BN1 9QJ, UK
    Nat Prod Rep 30:1346-56. 2013
    ..There are 169 references...
  83. ncbi Bioactive clerodane diterpenoids from the twigs of Casearia balansae
    Jing Xu
    State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Tianjin Key Laboratory of Molecular Drug Research, and School of Medicine, Nankai University, Tianjin 300071, People s Republic of China
    J Nat Prod 77:2182-9. 2014
    Eight new clerodane diterpenes, balanspenes A-H (1-8), along with two known analogues (9 and 10), were isolated from the twigs of Casearia balansae...
  84. pmc Effect of kappa-opioid receptor agonists U69593, U50488H, spiradoline and salvinorin A on cocaine-induced drug-seeking in rats
    Aashish S Morani
    School of Biological Sciences, Victoria University of Wellington, P O Box 600, Wellington, New Zealand
    Pharmacol Biochem Behav 94:244-9. 2009
    ..0mg/kg, I.P.) had no effect on operant responding to obtain sucrose reinforcement or on cocaine-induced hyperactivity. These findings show that Sal A, like other traditional KOPr agonists attenuates cocaine-induced drug-seeking behavior...
  85. ncbi Structure determination of chamaedryosides A-C, three novel nor-neo-clerodane glucosides from Teucrium chamaedrys, by NMR spectroscopy
    Antonio Fiorentino
    Dipartimento di Scienze della Vita, Laboratorio di Fitochimica, Seconda Universita degli Studi di Napoli, Via Vivaldi 43, 81100 Caserta, Italy
    Magn Reson Chem 47:1007-12. 2009
    Three new nor-neo-clerodane diterpenes, named chamaedryoside A (1), B (2) and C (3), have been isolated from the organic extracts of Teucrium chamaedrys (L...
  86. ncbi Legally high? Legal considerations of Salvia divinorum
    O Hayden Griffin
    Department of Criminology, Law, and Society, University of Florida, Gainesville, FL 32611 5950, USA
    J Psychoactive Drugs 40:183-91. 2008
    ..Lastly, the implications of various state laws are discussed...
  87. ncbi Effect of essential oil obtained from Croton cajucara Benth. on gastric ulcer healing and protective factors of the gastric mucosa
    C A Hiruma-Lima
    Departamento de Fisiologia, Instituto de Biociencias, Universidade Estadual Paulista, Botucatu, SP, Brazil
    Phytomedicine 9:523-9. 2002
    ..Thus, the protective and healing actions of the essential oil from C. cajucara bark on gastric lesions resulted mainly from an increase in PGE2 release and gastric mucus formation which would protect the gastric mucosa...
  88. ncbi Broad tuning of the human bitter taste receptor hTAS2R46 to various sesquiterpene lactones, clerodane and labdane diterpenoids, strychnine, and denatonium
    Anne Brockhoff
    Department of Molecular Genetics, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    J Agric Food Chem 55:6236-43. 2007
    ....
  89. ncbi Antifeedant neo-clerodanes from Teucrium tomentosum Heyne. (Labiatae)
    G N Krishna Kumari
    T R Govindachari Centre for Natural Products, SPIC Science Foundation, 88, Mount Road, Chennai 600 032, India
    Phytochemistry 64:1119-23. 2003
    ..All the compounds showed effective antifeedancy against Plutella xylostella and Spodoptera litura at 10 mug/cm(2) of leaf area...
  90. ncbi Neo-clerodane diterpenoids from Croton schiedeanus
    Pilar Puebla
    Departamento de Quimica Farmaceutica, Facultad de Farmacia, E 37007, Salamanca, Spain
    Phytochemistry 62:551-5. 2003
    ..type furano diterpenoids were isolated from the aerial part of Croton schiedeanus, besides the clerodane diterpenes cis- and trans-dehydrocrotonin, previously isolated from other species of Croton...
  91. ncbi Direct analysis of Salvia divinorum leaves for salvinorin A by thin layer chromatography and desorption electrospray ionization multi-stage tandem mass spectrometry
    Joseph H Kennedy
    Prosolia, Inc, Indianapolis, IN 46202, USA
    Rapid Commun Mass Spectrom 24:1305-11. 2010
    ..The present study provides an example of both the direct analysis of intact plant materials for screening illicit substances and the coupling of TLC and DESI-MS as a simple method for the examination of natural products...
  92. pmc Differential effects of opioid agonists on G protein expression in CHO cells expressing cloned human opioid receptors
    Heng Xu
    Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, Baltimore, MD 21224, USA
    Brain Res Bull 77:49-54. 2008
    ....
  93. ncbi Detection of synergistic combinations of Baccharis extracts with terbinafine against Trichophyton rubrum with high throughput screening synergy assay (HTSS) followed by 3D graphs. Behavior of some of their components
    María Victoria Rodríguez
    Pharmacognosy Area, School of Biochemical and Pharmaceutical Sciences, National University of Rosario, Suipacha 531, 2000 Rosario, Argentina Vegetal Biology Area, School of Biochemical and Pharmaceutical Sciences, National University of Rosario, Suipacha 531, 2000 Rosario, Argentina
    Phytomedicine 20:1230-9. 2013
    ..Results showed that ent-clerodanes but not flavonoids showed synergistic or additive effects. Among them, bacchotricuneatin A followed by bacrispine showed synergistic effects while hawtriwaic acid showed additive effects. ..
  94. ncbi Intramolecular transacetylation in salvinorins D and E
    Lukasz M Kutrzeba
    Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, Mississippi 38677 1848, USA
    J Nat Prod 73:707-8. 2010
    ..The presence of both compounds was readily observed in the (1)H NMR spectrum. This spontaneous formation of the mixture of isomers occurs via a dynamic intramolecular transacetylation process...
  95. pmc The discriminative effects of the kappa-opioid hallucinogen salvinorin A in nonhuman primates: dissociation from classic hallucinogen effects
    Eduardo R Butelman
    Laboratory on the Biology of Addictive Diseases, The Rockefeller University, Box 171, New York, NY 10065, USA
    Psychopharmacology (Berl) 210:253-62. 2010
    ....
  96. ncbi Salvinorin A fails to substitute for the discriminative stimulus effects of LSD or ketamine in Sprague-Dawley rats
    Bryan A Killinger
    Department of Psychology, Western Michigan University, Kalamazoo, MI 49008 5439, USA
    Pharmacol Biochem Behav 96:260-5. 2010
    ..These findings are consistent with the growing body of evidence that salvinorin A is pharmacologically distinct from other traditional hallucinogenic compounds...
  97. ncbi Scutebarbatines W-Z, new neo-clerodane diterpenoids from Scutellaria barbata and structure revision of a series of 13-spiro neo-clerodanes
    Fei Wang
    State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China
    Chem Pharm Bull (Tokyo) 58:1267-70. 2010
    ....
  98. pmc Salvinorin A analogs as probes in opioid pharmacology
    Thomas E Prisinzano
    Department of Medicinal Chemistry, The University of Kansas, Lawrence, Kansas 66049, USA
    Chem Rev 108:1732-43. 2008
  99. ncbi Inhibition of P-glycoprotein-induced multidrug resistance by a clerodane-type diterpenoid from Sindora sumatrana
    Ho Jin Jung
    Division of Life and Pharmaceutical Sciences and College of Pharmacy, Ewha Womans University, 11 1 Daehyun Dong, Seodaemun gu, Seoul 120 750, Korea
    Chem Biodivers 7:2095-101. 2010
    ..These results suggest that compound 1 inhibits the functioning of P-gp and, therefore, can be developed as an MDR-reversing agent...
  100. pmc Modification of the furan ring of salvinorin A: identification of a selective partial agonist at the kappa opioid receptor
    Cecile Beguin
    Mailman Research Center, McLean Hospital, Belmont, MA 02478, USA
    Bioorg Med Chem 17:1370-80. 2009
    ..Finally, substitution of oxadiazoles for the furan ring abolished affinity for the KOPR. None of the compounds displayed any KOPR antagonism or any affinity for mu or delta opioid receptors...
  101. ncbi Evaluation of the antiprotozoal activity of neo-clerodane type diterpenes from Salvia polystachya against Entamoeba histolytica and Giardia lamblia
    Fernando Calzada
    Unidad de Investigación Médica en Farmacología de Productos Naturales, UMAE Hospital de Pediatria, Centro Medico Nacional Siglo XXI, IMSS, Mexico DF, Mexico
    Phytother Res 24:662-5. 2010
    ..In this study the main neo-clerodane diterpenes (polystachynes A, B and D, as well as linearolactone) were isolated from the aerial parts of chia, and ..

Research Grants14

  1. Salvinorin A: A Structurally Novel Opioid Agonist Lead
    Christopher McCurdy; Fiscal Year: 2004
    ..Results of this work will direct further analog development of Salvinorin A (a next generation) and further define and refine our proposed computer binding and field models. ..
  2. NEW METHODOLOGY FOR THE SYNTHESIS OF ANTITUMOR AGENTS
    Jeffrey Winkler; Fiscal Year: 1992
    ..The constructions of the carbon skeleta of the ingenane and clerodane diterpenes, taxusin, mesembrine, and the vinca alkaloids outlined in this proposal attest to the considerable ..
  3. TOTAL SYNTHESIS OF CLERODANE DITERPENES
    Michael Taschner; Fiscal Year: 1990
    ..It is hoped this can be extended to ultimately control the stereochemistry at five contiguous asymmetric centers not only in a relative sense but also in an absolute sense as well...
  4. kappa-agonist effects of the hallucinogen Salvinorin A
    Eduardo Butelman; Fiscal Year: 2008
    ....
  5. EFFECTS OF SYSTEMICALLY ADMINISTERED DYNORPHINS
    Eduardo Butelman; Fiscal Year: 2002
    ....
  6. Consequences of repeated kappa receptor activation on brain stimulation reward
    Elena Chartoff; Fiscal Year: 2006
    ..abstract_text> ..
  7. Effects of self-administered MDMA on brain and behavior in rhesus monkeys
    William Fantegrossi; Fiscal Year: 2007
    ..Thus, these studies are likely to be more relevant to the potential human condition of MDMA-induced lasting neurochemical alterations and behavioral changes [unreadable] [unreadable]..
  8. AMINO ACID CONJUGATION OF BILE ACIDS
    Stephen Barnes; Fiscal Year: 2006
    ..abstract_text> ..
  9. Role of dopamine D1 receptors in morphine withdrawal
    Elena Chartoff; Fiscal Year: 2006
    ..This work may lead to new pharmacotherapies that can alleviate aversive and dysphoric states associated with opiate withdrawal and perhaps reduce relapse to drug taking. ..
  10. GHB: Discrimination and effects on learning
    Lisa Baker; Fiscal Year: 2003
    ..Behavior under these assays is sensitive to other abused drugs. Therefore, these assays may be of value in characterizing the effects of GHB. ..
  11. A sensitive triple quadrupole mass spectrometer
    Stephen Barnes; Fiscal Year: 2004
    ..It is anticipated that a commercial nanospray interface for use in nanoLC-MS analysis will be available by the fall of 2003. ..
  12. 9.4 Tesla Fourier Transform Mass Spectrometer
    Stephen Barnes; Fiscal Year: 2002
    ..Overall, the FT-MS instrument will sustain the high quality of biomedical research that is a hallmark of UAB. ..
  13. Center for Nutrient-Gene Interaction in Cancer Preventi*
    Stephen Barnes; Fiscal Year: 2008
    ..In addition to the main projects, the Center will organize a competitive Pilot Project/Developmental program for the evaluation of new ideas and methods pertinent to the overall development of the Center. ..