Summary: A class of compounds composed of repeating 5-carbon units of HEMITERPENES.

Top Publications

  1. ncbi Defensive function of herbivore-induced plant volatile emissions in nature
    A Kessler
    Department of Molecular Ecology, Max-Planck-Institute for Chemical Ecology, Jena 07745, Germany
    Science 291:2141-4. 2001
  2. ncbi Evolution of secondary metabolites from an ecological and molecular phylogenetic perspective
    Michael Wink
    Universitat Heidelberg, Institut für Pharmazie und molekulare Biotechnologie, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany
    Phytochemistry 64:3-19. 2003
  3. pmc Isoprenoid biosynthesis: the evolution of two ancient and distinct pathways across genomes
    B M Lange
    Institute of Biological Chemistry, Washington State University, Pullman, WA 99164 6340, USA
    Proc Natl Acad Sci U S A 97:13172-7. 2000
  4. ncbi Biosynthesis of plant isoprenoids: perspectives for microbial engineering
    James Kirby
    California Institute of Quantitative Biomedical Research, University of California, Berkeley, California 94720, USA
    Annu Rev Plant Biol 60:335-55. 2009
  5. pmc Macroalgal terpenes function as allelopathic agents against reef corals
    Douglas B Rasher
    Schools of Biology and Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Proc Natl Acad Sci U S A 108:17726-31. 2011
  6. ncbi Terpenes from Copaifera demonstrated in vitro antiparasitic and synergic activity
    Erika Izumi
    Programa de Pós Graduação em Microbiologia, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid s n 86051 990 Londrina PR, Brazil
    J Med Chem 55:2994-3001. 2012
  7. pmc Terpenoid metabolism in wild-type and transgenic Arabidopsis plants
    Asaph Aharoni
    Plant Research International, 6700 AA, Wageningen, The Netherlands
    Plant Cell 15:2866-84. 2003
  8. ncbi Metabolic pathways in the apicoplast of apicomplexa
    Frank Seeber
    Robert Koch Institut, Berlin, Germany
    Int Rev Cell Mol Biol 281:161-228. 2010
  9. ncbi Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression
    Karanam Balasubramanyam
    Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore 560064, India
    J Biol Chem 279:33716-26. 2004
  10. ncbi Terpenoids: opportunities for biosynthesis of natural product drugs using engineered microorganisms
    Parayil Kumaran Ajikumar
    Department of Chemical Engineering, Room 56 469, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Mol Pharm 5:167-90. 2008

Detail Information

Publications399 found, 100 shown here

  1. ncbi Defensive function of herbivore-induced plant volatile emissions in nature
    A Kessler
    Department of Molecular Ecology, Max-Planck-Institute for Chemical Ecology, Jena 07745, Germany
    Science 291:2141-4. 2001
    ..As a consequence, a plant could reduce the number of herbivores by more than 90% by releasing volatiles. These results confirm that indirect defenses can operate in nature...
  2. ncbi Evolution of secondary metabolites from an ecological and molecular phylogenetic perspective
    Michael Wink
    Universitat Heidelberg, Institut für Pharmazie und molekulare Biotechnologie, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany
    Phytochemistry 64:3-19. 2003
    ..Thus, the distribution of secondary metabolites has some value for taxonomy but their occurrence apparently reflects adaptations and particular life strategies embedded in a given phylogenetic framework...
  3. pmc Isoprenoid biosynthesis: the evolution of two ancient and distinct pathways across genomes
    B M Lange
    Institute of Biological Chemistry, Washington State University, Pullman, WA 99164 6340, USA
    Proc Natl Acad Sci U S A 97:13172-7. 2000
    ..The results suggest that lateral gene transfer between eubacteria subsequent to the origin of plastids has played a major role in the evolution of this pathway...
  4. ncbi Biosynthesis of plant isoprenoids: perspectives for microbial engineering
    James Kirby
    California Institute of Quantitative Biomedical Research, University of California, Berkeley, California 94720, USA
    Annu Rev Plant Biol 60:335-55. 2009
    ..Here, we review investigations into isoprenoid function and gene discovery in plants as well as the latest advances in isoprenoid pathway engineering in both plant and microbial hosts...
  5. pmc Macroalgal terpenes function as allelopathic agents against reef corals
    Douglas B Rasher
    Schools of Biology and Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Proc Natl Acad Sci U S A 108:17726-31. 2011
    ..Our results highlight a newly demonstrated but potentially widespread competitive mechanism to help explain the lack of coral recovery on many present-day reefs...
  6. ncbi Terpenes from Copaifera demonstrated in vitro antiparasitic and synergic activity
    Erika Izumi
    Programa de Pós Graduação em Microbiologia, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid s n 86051 990 Londrina PR, Brazil
    J Med Chem 55:2994-3001. 2012
    ..we evaluated against all Trypanosoma cruzi life stages the in vitro trypanocidal and synergistic activity of terpenes isolated from Copaifera oleoresins collected in the Amazon and investigated their possible mechanism of action...
  7. pmc Terpenoid metabolism in wild-type and transgenic Arabidopsis plants
    Asaph Aharoni
    Plant Research International, 6700 AA, Wageningen, The Netherlands
    Plant Cell 15:2866-84. 2003
    ..This study further demonstrates the value of Arabidopsis for studies of the biosynthesis and ecological role of terpenoids and provides new insights into their metabolism in wild-type and transgenic plants...
  8. ncbi Metabolic pathways in the apicoplast of apicomplexa
    Frank Seeber
    Robert Koch Institut, Berlin, Germany
    Int Rev Cell Mol Biol 281:161-228. 2010
    ..Finally, we highlight some aspects that emerged from recent publications and were not discussed previously with regard to Apicomplexa...
  9. ncbi Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression
    Karanam Balasubramanyam
    Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore 560064, India
    J Biol Chem 279:33716-26. 2004
    ..Furthermore, it was found to be a potent inducer of apoptosis, and it alters (predominantly down-regulates) the global gene expression in HeLa cells...
  10. ncbi Terpenoids: opportunities for biosynthesis of natural product drugs using engineered microorganisms
    Parayil Kumaran Ajikumar
    Department of Chemical Engineering, Room 56 469, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Mol Pharm 5:167-90. 2008
    ..This review focuses on the biodiversity of terpenoids, the biosynthetic pathways involved, and engineering efforts to maximize the production through these pathways...
  11. ncbi Origins and early evolution of the mevalonate pathway of isoprenoid biosynthesis in the three domains of life
    Jonathan Lombard
    Unité d Ecologie, Systematique et Evolution, Centre National de la Recherche Scientifique, Universite Paris Sud, Orsay, France
    Mol Biol Evol 28:87-99. 2011
    ..These findings open the possibility that the cenancestor had membranes containing isoprenoids...
  12. pmc A high quality draft consensus sequence of the genome of a heterozygous grapevine variety
    Riccardo Velasco
    IASMA Research Center, San Michele all Adige, Trento, Italy
    PLoS ONE 2:e1326. 2007
    ..In this paper a high quality draft genome sequence of a cultivated clone of V. vinifera Pinot Noir is presented...
  13. ncbi Phytoalexins from the Vitaceae: biosynthesis, phytoalexin gene expression in transgenic plants, antifungal activity, and metabolism
    Philippe Jeandet
    Laboratoire d Oenologie, URVVC, UPRES EA 2069, Faculte des Sciences, Universite de Reims, B P 1039, 51687 Reims Cedex 02, France
    J Agric Food Chem 50:2731-41. 2002
  14. ncbi Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene
    Jennifer R Anthony
    California Institute for Quantitative Biomedical Research, University of California, Berkeley, CA 94720, USA
    Metab Eng 11:13-9. 2009
    ..The methods demonstrated here are applicable for identifying and eliminating rate-limiting steps in other constructed biosynthetic pathways...
  15. pmc Induction of autoimmunity by pristane and other naturally occurring hydrocarbons
    Westley H Reeves
    Division of Rheumatology and Clinical Immunology, and Laboratory Medicine, University of Florida, PO Box 100221, Gainesville, FL 32610 0221, United States
    Trends Immunol 30:455-64. 2009
    ..This model is well suited for examining links between dysregulated IFN-I production and the pathogenesis of human SLE, which like TMPD-lupus, is associated with high levels of IFN-I...
  16. ncbi Structural biology and chemistry of the terpenoid cyclases
    David W Christianson
    Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104 6323, USA
    Chem Rev 106:3412-42. 2006
  17. ncbi Inhibitory effect of cyclic terpenes (limonene, menthol, menthone and thymol) on Fusarium verticillioides MRC 826 growth and fumonisin B1 biosynthesis
    J S Dambolena
    IMBIV CONICET Cátedra de Química Orgánica, Facultad de Ciencias Exactas Fisicas y Naturales, Universidad Nacional de Cordoba, Cordoba, Argentina
    Toxicon 51:37-44. 2008
    The minimum inhibitory concentration (MIC) of cyclic terpenes (limonene, menthol, menthone and thymol) against Fusarium verticillioides MRC 826 was assessed by using the semisolid agar antifungal susceptibility (SAAS) technique...
  18. ncbi The MEP pathway: a new target for the development of herbicides, antibiotics and antimalarial drugs
    M Rodriguez-Concepcion
    Department de Bioquimica i Biologia Molecular, Facultat de Quimica, Universidad de Barcelona, Barcelona, Spain
    Curr Pharm Des 10:2391-400. 2004
    ..Current efforts should eventually contribute to an effective drug designed to fight against microbial pathogens that show resistance to currently available agents...
  19. ncbi Priming defense genes and metabolites in hybrid poplar by the green leaf volatile cis-3-hexenyl acetate
    Christopher J Frost
    Center for Chemical Ecology, Pennsylvania State University, University Park, PA 16802, USA
    New Phytol 180:722-34. 2008
    ..Thus, woody plants can detect and use z3HAC as a signal to prime defenses before actually experiencing damage. GLVs may therefore have important ecological functions in arboreal ecosystems...
  20. ncbi The methylerythritol phosphate pathway for isoprenoid biosynthesis in coccidia: presence and sensitivity to fosmidomycin
    Marc Clastre
    EA2106 Biomolécules et Biotechnologies Végétales, UFR Sciences Pharmaceutiques, Universite de Tours, 37200 Tours, France
    Exp Parasitol 116:375-84. 2007
    ..tenella and T. gondii growth in vitro. The drug was poorly effective even at high concentrations. Thus, both fosmidomycin sensitivity and isoprenoid metabolism differs substantially between apicomplexan species...
  21. ncbi Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli
    Douglas J Pitera
    Department of Chemical Engineering, University of California, Berkeley, CA 94720 1462, USA
    Metab Eng 9:193-207. 2007
    ..These results demonstrate that balancing carbon flux through the heterologous pathway is a key determinant in optimizing isoprenoid biosynthesis in microbial hosts...
  22. ncbi Engineering a mevalonate pathway in Escherichia coli for production of terpenoids
    Vincent J J Martin
    Department of Chemical Engineering, 201 Gilman Hall, University of California, Berkeley, California 94720 1462, USA
    Nat Biotechnol 21:796-802. 2003
  23. ncbi Biosynthesis of isoprenoids via the non-mevalonate pathway
    W Eisenreich
    Lehrstuhl fur Organische Chemie und Biochemie, Technische Universitat Munchen, Lichtenbergstr 4, 85747 Garching, Germany
    Cell Mol Life Sci 61:1401-26. 2004
    ..Detailed knowledge about the mechanisms of this novel route may benefit the development of novel antibiotics, antimalarials and herbicides...
  24. pmc EST analysis of hop glandular trichomes identifies an O-methyltransferase that catalyzes the biosynthesis of xanthohumol
    Jana Nagel
    National Research Council Plant Biotechnology Institute, Saskatoon, Saskatchewan, Canada S7N 0W9
    Plant Cell 20:186-200. 2008
    ..OMT3 was inactive with all substrates tested. The lupulin gland-specific EST data set expands the genomic resources for H. lupulus and provides further insight into the metabolic specialization of glandular trichomes...
  25. ncbi Targeted proteomics using selected reaction monitoring reveals the induction of specific terpene synthases in a multi-level study of methyl jasmonate-treated Norway spruce (Picea abies)
    Katherine G Zulak
    Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada
    Plant J 60:1015-30. 2009
  26. ncbi Apoptosis-inducing effect of garcinol is mediated by NF-kappaB signaling in breast cancer cells
    Aamir Ahmad
    Department of Pathology, Wayne State University School of Medicine and Barbara Ann Karmanos Cancer Center, Detroit, MI 48201, USA
    J Cell Biochem 109:1134-41. 2010
  27. ncbi TLR9 and TLR4 are required for the development of autoimmunity and lupus nephritis in pristane nephropathy
    S A Summers
    Centre for Inflammatory Diseases, Monash University Department of Medicine, 246 Clayton Rd, Clayton, VIC 3168, Australia
    J Autoimmun 35:291-8. 2010
    ..These results demonstrate that both TLR9 and TLR4 are required for 'full-blown' autoimmunity and organ injury in experimental lupus induced by pristane...
  28. ncbi Natural isoprenoids inhibit LPS-induced-production of cytokines and nitric oxide in aminobisphosphonate-treated monocytes
    Annalisa Marcuzzi
    Department of Reproductive and Developmental Sciences, University of Trieste, Italy
    Int Immunopharmacol 10:639-42. 2010
    ..These natural isoprenoids could be proposed as novel therapeutic approach for the still orphan drug MKD, but also considered for the evaluation of possible inflammatory side effects of aminobisphosphonates...
  29. ncbi A unified mechanism of action for volatile isoprenoids in plant abiotic stress
    Claudia E Vickers
    University of Queensland, Australian Institute for Bioengineering and Nanotechnology, St Lucia, Australia
    Nat Chem Biol 5:283-91. 2009
  30. ncbi Manipulating the stereoselectivity of limonene epoxide hydrolase by directed evolution based on iterative saturation mutagenesis
    Huabao Zheng
    Max Planck Institut für Kohlenforschung, Kaiser Wilhelm Platz 1, 45470 Mülheim an der Ruhr, Germany
    J Am Chem Soc 132:15744-51. 2010
    ..In order to explain some of the stereoselective consequences of the observed mutations, a simple model based on molecular dynamics simulations has been proposed...
  31. pmc Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway
    Eiji Okamura
    Biotechnology Research Center, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Proc Natl Acad Sci U S A 107:11265-70. 2010
    ..This result suggests that nphT7 can be used to significantly increase the concentration of acetoacetyl-CoA in cells, eventually leading to the production of useful terpenoids and poly-beta-hydroxybutyrate...
  32. ncbi Biomimetic synthesis of thiaplidiaquinones A and B
    Iman M Khalil
    School of Chemical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
    J Nat Prod 75:2256-60. 2012
    ..Subsequent reaction with hypotaurine yielded the title compounds and their dioxothiazino regioisomers...
  33. ncbi Natural isoprenoids are able to reduce inflammation in a mouse model of mevalonate kinase deficiency
    Annalisa Marcuzzi
    Department of Reproductive and Developmental Sciences, University of Trieste, Trieste, Italy
    Pediatr Res 64:177-82. 2008
    ..All these compounds were effective in preventing the inflammation induced by alendronate-muramyldipeptide, suggesting a possible role for these compounds in the treatment of MKD in humans...
  34. ncbi Biomimetic synthesis of the apoptosis-inducing thiazinoquinone thiaplidiaquinone A
    Anna Carbone
    School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    J Org Chem 77:9179-89. 2012
    ..This is followed by the installation of the 1,4-thiazine-dioxide ring by reaction of the benzo[c]chromene quinone with hypotaurine...
  35. ncbi Hyperforin in St. John's wort drug interactions
    Rajanikanth Madabushi
    Department of Pharmaceutics, College of Pharmacy, University of Florida, P O 100494, Gainesville, 32610, USA
    Eur J Clin Pharmacol 62:225-33. 2006
    ..In the present paper clinical significant SJW interactions are critically evaluated against the background of hyperforin...
  36. ncbi Enhancement of natural disease resistance in potatoes by chemicals
    Adriana B Andreu
    Instituto de Investigaciones Biologicas, Universidad Nacional de Mar del Plata, Funes 3250, 7600 Mar del Plata, Argentina
    Pest Manag Sci 62:162-70. 2006
    ..This treatment may offer the possibility of controlling both foliage and tuber blight and could have a major impact in reducing over-winter survival of P. infestans in tubers...
  37. ncbi Crocetin, dimethylcrocetin, and safranal bind human serum albumin: stability and antioxidative properties
    Charalabos D Kanakis
    Laboratory of Chemistry, Department of Science, Agricultural University of Athens, 75 Iera Odos, 11855 Athens, Greece
    J Agric Food Chem 55:970-7. 2007
    ..8%, which corresponds to a concentration of 40 microg/mL, and then started to decrease. The IC50 values of Trolox and BHT were 5.2 +/- 1 microg/mL and 5.3 +/- 1 microg/mL, respectively...
  38. ncbi Inhibitory effects of garcinol and pterostilbene on cell proliferation and adipogenesis in 3T3-L1 cells
    Chin Lin Hsu
    School of Nutrition, Chung Shan Medical University and Department of Nutrition, Chung Shan Medical University Hospital, No 110, Section 1, Jianguo North Road, Taichung 40201, Taiwan
    Food Funct 3:49-57. 2012
    ..These results suggest that garcinol and pterostilbene have anti-adipogenic effects on preadipocytes and adipocytes...
  39. ncbi The role of ozone-reactive compounds, terpenes, and green leaf volatiles (glvs), in the orientation of Cotesia plutellae
    Delia M Pinto
    Department of Environmental Science, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    J Chem Ecol 33:2218-28. 2007
    The emission of inducible volatile organic compounds (VOCs), i.e., inducible terpenes, and green leaf volatiles (GLVs), is a common response of plants to herbivore attack. These VOCs are involved in the orientation of natural enemies, i.e...
  40. pmc Engineering microbial factories for synthesis of value-added products
    Jing Du
    Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Ind Microbiol Biotechnol 38:873-90. 2011
    ..Related topics on lignocellulose degradation, sugar utilization, and microbial tolerance improvement will also be discussed...
  41. pmc Identification of genes and proteins necessary for catabolism of acyclic terpenes and leucine/isovalerate in Pseudomonas aeruginosa
    Karin Förster-Fromme
    Institut fur Mikrobiologie, Universitat Stuttgart, Allmandring 31, 70550 Stuttgart, Germany
    Appl Environ Microbiol 72:4819-28. 2006
    ..methylcrotonyl-CoA-carboxylase (MCase; LiuB/LiuD) are characteristic enzymes of the catabolic pathway of acyclic terpenes (citronellol and geraniol) and of saturated methyl-branched compounds, such as leucine or isovalerate, ..
  42. ncbi Marine natural products targeting phospholipases A2
    Florence Folmer
    Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Fondation de Recherche Cancer et Sang, Hopital Kirchberg, 9 rue Edward Steichen, L 2540 Luxembourg, Luxembourg
    Biochem Pharmacol 80:1793-800. 2010
    ..Here, we review the properties of marine PLA(2) inhibitors identified since the first discovery of PLA(2) inhibitory activity in the marine natural product manoalide in the mid 1980s...
  43. ncbi The non-mevalonate pathway of isoprenoid precursor biosynthesis
    William N Hunter
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Scotland, UK
    J Biol Chem 282:21573-7. 2007
    ..Detailed knowledge of the pathway may also be exploited to genetically modify microorganisms and plants to produce compounds of agricultural and medical interest...
  44. ncbi Botanical insecticides, deterrents, and repellents in modern agriculture and an increasingly regulated world
    Murray B Isman
    Faculty of Land and Food Systems, University of British Columbia, Vancouver, Canada
    Annu Rev Entomol 51:45-66. 2006
  45. ncbi A raison d'être for two distinct pathways in the early steps of plant isoprenoid biosynthesis?
    Andrea Hemmerlin
    Institut de Biologie Moléculaire des Plantes du Centre National de la Recherche Scientifique, IBMP CNRS UPR2357, Universite de Strasbourg, 28 rue Goethe, F 67083 Strasbourg cedex, France
    Prog Lipid Res 51:95-148. 2012
    ..This latter aspect still requires more work and present conclusions are preliminary, although some general features seem to exist...
  46. ncbi The non-major histocompatibility complex quantitative trait locus Cia10 contains a major arthritis gene and regulates disease severity, pannus formation, and joint damage
    Max Brenner
    Laboratory of Experimental Rheumatology, R S Boas Center for Genomics and Human Genetics, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    Arthritis Rheum 52:322-32. 2005
  47. ncbi Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo
    Takashi Ochiai
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Biochim Biophys Acta 1770:578-84. 2007
  48. pmc TLR7-dependent and FcgammaR-independent production of type I interferon in experimental mouse lupus
    Pui Y Lee
    Division of Rheumatology and Clinical Immunology and Center for Autoimmune Disease, University of Florida, Gainesville, FL 32610, USA
    J Exp Med 205:2995-3006. 2008
    ..Collectively, the data demonstrate that TMPD-stimulated IFN-I production requires TLR7/MyD88 signaling and is independent of autoantibody-mediated uptake of ribonucleoproteins by FcgammaRs...
  49. ncbi Terpinen-4-ol, the main component of Melaleuca alternifolia (tea tree) oil inhibits the in vitro growth of human melanoma cells
    Annarica Calcabrini
    Laboratorio di Ultrastrutture, Istituto Superiore di Sanita, Rome, Italy
    J Invest Dermatol 122:349-60. 2004
  50. ncbi The influence of Ceratocystis polonica inoculation and methyl jasmonate application on terpene chemistry of Norway spruce, Picea abies
    Tao Zhao
    Ecological Chemistry Group, Department of Chemistry, Royal Institute of Technology, SE 100 44 Stockholm, Sweden
    Phytochemistry 71:1332-41. 2010
    ..Spraying the stems with MJ tended to generally increase the concentration of most major terpenes with minor alteration to their relative proportions, but significant increases were only observed for (-)-beta-..
  51. ncbi Above- and below-ground terpenoid aldehyde induction in cotton, Gossypium herbaceum, following root and leaf injury
    T M Bezemer
    Netherlands Institute of Ecology NIOO KNAW, Centre for Terrestrial Ecology, PO Box 40, 6666 ZG Heteren, The Netherlands
    J Chem Ecol 30:53-67. 2004
    ..Plants exposed to both root and foliar herbivory appeared to induce primarily above-ground at the cost of below-ground defense. The implications for above- and below-ground Mutitrophic interactions are discussed...
  52. ncbi Effect of safranal, a constituent of Crocus sativus (saffron), on methyl methanesulfonate (MMS)-induced DNA damage in mouse organs: an alkaline single-cell gel electrophoresis (comet) assay
    Hossein Hosseinzadeh
    Faculty of Pharmacy, Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, I R Iran
    DNA Cell Biol 26:841-6. 2007
  53. ncbi A role for geranylgeranylation in interleukin-1beta secretion
    Saskia H L Mandey
    Emma Children s Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Arthritis Rheum 54:3690-5. 2006
    ..The goal of our study was to determine whether a temporary shortage of certain isoprenoid end products and/or the accumulation of mevalonic acid is the cause of interleukin-1beta (IL-1beta) secretion in MKD...
  54. ncbi Safranal, a constituent of Crocus sativus (saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampus
    Hossein Hosseinzadeh
    Pharmaceutical Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I R Iran
    J Pharm Pharm Sci 8:394-9. 2005
    ..31 vs. 159.70 nmol/g, p<0.001; 727.5 mg/kg). It is concluded that safranal have some protective effects on different markers of oxidative damage in hippocampal tissue from ischemic rats...
  55. pmc Protective and pathogenic roles for B cells during systemic autoimmunity in NZB/W F1 mice
    Karen M Haas
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 184:4789-800. 2010
    ..Therefore, distinct B cell populations can have opposing protective and pathogenic roles during lupus progression...
  56. pmc Bioactive sesterterpenes and triterpenes from marine sponges: occurrence and pharmacological significance
    Sherif S Ebada
    Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University, Duesseldorf, Germany
    Mar Drugs 8:313-46. 2010
    ..In this review, we survey sesterterpenoids and triterpenoids obtained from marine sponges and highlight their bioactivities...
  57. ncbi Diversity of the biosynthesis of the isoprene units
    Tomohisa Kuzuyama
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Tokyo 113 0032, Japan
    Nat Prod Rep 20:171-83. 2003
    ..e type 2 IPP isomerase. The biosynthesis of terpenoids produced by actinomycetes is also reviewed. 117 references are cited...
  58. ncbi Anxiolytic and hypnotic effect of Crocus sativus aqueous extract and its constituents, crocin and safranal, in mice
    Hossein Hosseinzadeh
    Department of Pharmacodynamy and Toxicology, School of Pharmacy, Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
    Phytother Res 23:768-74. 2009
    ..05 and 0.15 mL/kg) decreased some locomotion activity parameters. Safranal demonstrated no effects on motor coordination. The results showed that saffron aqueous extract and safranal have anxiolytic and hypnotic effects...
  59. ncbi Structure and dynamics of the isoprenoid pathway network
    Eva Vranová
    Department of Biology, Plant Biotechnology, ETH Zurich, Universitatstrasse 2, 8092 Zurich, Switzerland
    Mol Plant 5:318-33. 2012
    ..We conclude by discussing agronomical and biotechnological applications emerging from the plant isoprenoid metabolism and provide an outlook on future directions in the systems analysis of the plant isoprenoid pathway network...
  60. ncbi Distinct isoprenoid origins of cis- and trans-zeatin biosyntheses in Arabidopsis
    Hiroyuki Kasahara
    Laboratory for Cellular Growth and Development, Plant Science Center, RIKEN, Yokohoma, Japan
    J Biol Chem 279:14049-54. 2004
    ..Distinct origins of large proportions of DMAPP for tZ and cZ biosynthesis suggest that plants are able to separately modulate the level of these cytokinin species...
  61. ncbi Antioxidative and anti-glycation activity of garcinol from Garcinia indica fruit rind
    F Yamaguchi
    Research and Development Division, Kikkoman Corporation, Noda 399, Noda shi, Chiba Pref 278 0037, Japan
    J Agric Food Chem 48:180-5. 2000
    ..Thus, garcinol might be beneficial as a potent antioxidant and a glycation inhibitor under specified conditions...
  62. ncbi Monoterpenoid biosynthesis in Saccharomyces cerevisiae
    Marilyne Oswald
    UMR Santé de la Vigne et Qualité du Vin, Universite Louis Pasteur Strasbourg, Institut National de la Recherche Agronomique, Colmar, France
    FEMS Yeast Res 7:413-21. 2007
    ..We also showed that geraniol synthase expression affects the general ergosterol pathway, but in a manner dependent on the genetic background of the strain...
  63. pmc Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii
    Sethu C Nair
    Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA
    J Exp Med 208:1547-59. 2011
    ..We propose that the varied extent of metabolite exchange between host and parasite is a crucial determinator of drug susceptibility and a predictor of future resistance...
  64. ncbi Antibacterial effects of the essential oils of commonly consumed medicinal herbs using an in vitro model
    Marina Sokovic
    Plant Research International, Wageningen University and Research Centre, Droevendaalsesteeg 1, 6708PB Wageningen, The Netherlands
    Molecules 15:7532-46. 2010
    ..epidermidis, S. typhimurium, and Staphylococcus aureus. The highest and broadest activity was shown by O. vulgare oil. Carvacrol had the highest antibacterial activity among the tested components...
  65. pmc Cytotoxic terpene quinones from marine sponges
    Marina Gordaliza
    Department of Pharmaceutical Chemistry, Pharmacy Faculty, Salamanca University, Campus Miguel de Unamuno, Salamanca, Spain
    Mar Drugs 8:2849-70. 2010
    ..The present review summarizes the structure and cytotoxicity of natural terpenequinones/hydroquinones and their bioactive analogues and derivatives...
  66. pmc A second target of the antimalarial and antibacterial agent fosmidomycin revealed by cellular metabolic profiling
    Baichen Zhang
    Proteomics and Mass Spectrometry Facility, Donald Danforth Plant Science Center, St Louis, Missouri 63132, United States
    Biochemistry 50:3570-7. 2011
    ..This work has validated fosmidomycin as a biological reagent for blocking non-mevalonate isoprenoid metabolism and suggests a second in vivo target for fosmidomycin within isoprenoid biosynthesis, in two evolutionarily diverse pathogens...
  67. ncbi In vitro activity of terpenes against Candida biofilms
    Stéphanie Dalleau
    UMR 6008, Universite de Poitiers, CNRS, 6 rue de la Miletrie, BP 199, 86034 Poitiers Cedex, France
    Int J Antimicrob Agents 31:572-6. 2008
    The antibiofilm activity of 10 terpenes was tested in vitro against three Candida species by 24-h treatment of biofilms aged 1-5 days. Treatment of 24-h-old Candida albicans biofilms with carvacrol, geraniol or thymol (0...
  68. pmc Silencing geranylgeranyl diphosphate synthase in Nicotiana attenuata dramatically impairs resistance to tobacco hornworm
    Amir Reza Jassbi
    Department of Molecular Ecology, Max Planck Institute for Chemical Ecology, Jena, Germany
    Plant Physiol 146:974-86. 2008
    ..We conclude that HGL-DTGs or other minor undetected diterpenoids derived from GGPP function as direct defenses for N. attenuata and are more potent than nicotine or trypsin protease inhibitors against attack by hornworm larvae...
  69. pmc Interleukin 6 dependence of anti-DNA antibody production: evidence for two pathways of autoantibody formation in pristane-induced lupus
    H B Richards
    Department of Medicine, Thurston Arthritis Research Center, University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill 27599 7280, USA
    J Exp Med 188:985-90. 1998
    ..This may reflect the differential IL-6 dependence of the two responses...
  70. pmc Terpene biosynthesis in glandular trichomes of hop
    Guodong Wang
    Plant Biology Division, The Samuel Roberts Noble Foundation, Ardmore, Oklahoma 73410, USA
    Plant Physiol 148:1254-66. 2008
    ..We discuss potential functions for other genes expressed at high levels in developing hop trichomes...
  71. ncbi Isoprenoid biosynthesis in Artemisia annua: cloning and heterologous expression of a germacrene A synthase from a glandular trichome cDNA library
    Cinzia M Bertea
    Plant Research International, P O Box 16, 6700 AA Wageningen, The Netherlands
    Arch Biochem Biophys 448:3-12. 2006
    ..These results demonstrate the potential of the use of A. annua glandular trichomes as a starting material for studying isoprenoid biosynthesis in this plant species...
  72. pmc Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein
    Felix Rohdich
    Lehrstuhl fur Organische Chemie und Biochemie, Technische Universitat Munchen, Lichtenbergstrasse 4, D 85747 Garching, Germany
    Proc Natl Acad Sci U S A 99:1158-63. 2002
    Isopentenyl diphosphate and dimethylallyl diphosphate serve as the universal precursors for the biosynthesis of terpenes. Although their biosynthesis by means of mevalonate has been studied in detail, a second biosynthetic pathway for ..
  73. ncbi The correlation of evolutionary rate with pathway position in plant terpenoid biosynthesis
    Heather Ramsay
    Faculty of Forestry, Department of Forest Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Mol Biol Evol 26:1045-53. 2009
    ..Therefore, our results are consistent with the prediction that selective constraint is progressively relaxed along metabolic pathways...
  74. ncbi Biofuel alternatives to ethanol: pumping the microbial well
    J L Fortman
    Department of Chemical Engineering, University of California, 717 Potter Street, Building 977, Mail code 3224 Berkeley, CA 94720 3224, USA
    Trends Biotechnol 26:375-81. 2008
    ..To highlight additional options, we review advances in microbial engineering for the production of other potential fuel molecules, using a variety of biosynthetic pathways...
  75. ncbi Quorum sensing antagonism from marine organisms
    Mette Elena Skindersoe
    Department of Bioscience and Technology, Technical University of Denmark, Lyngby, Denmark
    Mar Biotechnol (NY) 10:56-63. 2008
  76. ncbi Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
    H Jomaa
    Institute of Biochemistry, Academic Hospital Centre, Justus Liebig University, Friedrichstrasse 24, D 35392 Giessen, Germany
    Science 285:1573-6. 1999
    ..Both drugs suppressed the in vitro growth of multidrug-resistant P. falciparum strains. After therapy with these drugs, mice infected with the rodent malaria parasite P. vinckei were cured...
  77. ncbi Isoprenoids control germ cell migration downstream of HMGCoA reductase
    Ana C Santos
    Howard Hughes Medical Institute, Developmental Genetics Program, Skirball Institute and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Dev Cell 6:283-93. 2004
    ..The specificity and evolutionary conservation of the HMGCoAr pathway for germ cells suggest that an attractant common to invertebrates and vertebrates guides germ cells in early embryos...
  78. ncbi Conifer defence against insects: microarray gene expression profiling of Sitka spruce (Picea sitchensis) induced by mechanical wounding or feeding by spruce budworms (Choristoneura occidentalis) or white pine weevils (Pissodes strobi) reveals large-scale
    Steven G Ralph
    Michael Smith Laboratories, University of British Columbia, Vancouver, Canada
    Plant Cell Environ 29:1545-70. 2006
    ..Induction of spruce genes of octadecanoid and ethylene signalling, terpenoid biosynthesis, and phenolic secondary metabolism are discussed in more detail...
  79. ncbi Specific inhibition of p300-HAT alters global gene expression and represses HIV replication
    K Mantelingu
    Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur P O Bangalore, India
    Chem Biol 14:645-57. 2007
    ..Remarkably, these inhibitors were found to be nontoxic to T cells, inhibit histone acetylation of HIV infected cells, and consequently inhibit the multiplication of HIV...
  80. ncbi Crystal structure of 1-deoxy-D-xylulose 5-phosphate synthase, a crucial enzyme for isoprenoids biosynthesis
    Song Xiang
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Biol Chem 282:2676-82. 2007
    ..The structures identify residues that may have important roles in catalysis, which have been confirmed by our mutagenesis studies...
  81. pmc Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress
    Albena T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:4584-9. 2005
    ..91) over 6 orders of magnitude of concentration. Thus, in addition to blocking inflammation and promoting differentiation, these TP exhibit another very important protective property: the induction of the phase 2 response...
  82. pmc Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol
    G A Sprenger
    Institut für Biotechnologie 1 des Forschungszentrums Jülich, Germany
    Proc Natl Acad Sci U S A 94:12857-62. 1997
  83. ncbi Geranyl diphosphate synthase is required for biosynthesis of gibberellins
    Chris C N van Schie
    Department of Plant Physiology, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    Plant J 52:752-62. 2007
    ..These results link geranyl diphosphate (GPP) to the gibberellin biosynthesis pathway. They also demand a re-evaluation of the role of GPS in precursor synthesis for other di-, tri-, tetra- and/or polyterpenes and their derivatives...
  84. ncbi Chemical composition and antibacterial activity of the essential oil and the gum of Pistacia lentiscus Var. chia
    Christina Koutsoudaki
    Department of Chemistry and Department of Biological Sciences, University of Warwick, Warwick, Coventry CV4 7AL, United Kingdom
    J Agric Food Chem 53:7681-5. 2005
    ..Mastic gum was also examined, but it proved to be more difficult to handle compared to the essential oil...
  85. ncbi A chemical investigation by headspace SPME and GC-MS of volatile and semi-volatile terpenes in various olibanum samples
    Sandrine Hamm
    Groupe de Chimie Analytique de Paris Sud LETIAM EA 3343, Institut Universitaire de Technologie d Orsay, Plateau de Moulon, F 91400 Orsay, France
    Phytochemistry 66:1499-514. 2005
    ..Furthermore, this study gave us the opportunity to assign a botanical origin to an archaeological frankincense sample...
  86. ncbi Terpenes from the red alga Sphaerococcus coronopifolius inhibit the settlement of barnacles
    Veronica Piazza
    Institute of Marine Science ISMAR CNR, Via De Marini 6, 16149 Genoa, Italy
    Mar Biotechnol (NY) 13:764-72. 2011
    In this study, we screened eight terpenes isolated from the organic extract of Sphaerococcus coronopifolius for their antifouling activity in order to find possible new sources of non-toxic or less toxic bioactive antifoulants...
  87. ncbi The biochemistry of homoterpenes--common constituents of floral and herbivore-induced plant volatile bouquets
    Dorothea Tholl
    Department of Biological Sciences, 408 Latham Hall, AgQuad Lane, Virginia Tech, Blacksburg, VA 24061, USA
    Phytochemistry 72:1635-46. 2011
  88. ncbi Antitumor effects of two novel naturally occurring terpene quinones isolated from the Mediterranean ascidian Aplidium conicum
    Anna Aiello
    Dipartimento di Chimica delle Sostanze Naturali, Universita degli Studi di Napoli Federico II, Via Domenico Montesano n 49 80131, Napoli, Italy
    J Med Chem 48:3410-6. 2005
    ..Thus, thiaplidiaquinones A and B can enter into the cells and induce cell death by apoptosis...
  89. ncbi Terpenes: substances useful in human healthcare
    Roman Paduch
    Department of Virology and Immunology, Institute of Microbiology and Biotechnology, Maria Curie Skłodowska University, Lublin, Poland
    Arch Immunol Ther Exp (Warsz) 55:315-27. 2007
    b>Terpenes are naturally occurring substances produced by a wide variety of plants and animals...
  90. ncbi The farnesyltransferase inhibitors tipifarnib and lonafarnib inhibit cytokines secretion in a cellular model of mevalonate kinase deficiency
    Annalisa Marcuzzi
    Medical Genetic Service, Institute for Maternal and Child Health Burlo Garofolo, Trieste 34134, Italy
    Pediatr Res 70:78-82. 2011
    ..The effect of GOH and Tip was successfully replicated in MKD patients' monocytes. Tip and Lon showed a dramatic anti-inflammatory effect in monocytes where mevalonate pathway was chemically or genetically impaired...
  91. pmc Two distinct pathways for essential metabolic precursors for isoprenoid biosynthesis
    Tomohisa Kuzuyama
    Biotechnology Research Center, The University of Tokyo, Tokyo, Japan
    Proc Jpn Acad Ser B Phys Biol Sci 88:41-52. 2012
    ..This review article focuses on our significant contributions to a comprehensive understanding of the biosynthesis of IPP and DMAPP...
  92. ncbi Distribution of aroma volatile compounds in tangerine hybrids and proposed inheritance
    Takayuki Miyazaki
    Institute of Food and Agricultural Sciences, University of Florida, Citrus Research and Education Center, Lake Alfred, FL 33850, USA
    J Sci Food Agric 91:449-60. 2011
    ..Principal component analysis (PCA) and cluster analysis (CA) were used to find similarities among samples due to volatile composition with effect of genetic background...
  93. ncbi Metabolic engineering of microorganisms for the synthesis of plant natural products
    Jan Marienhagen
    Institut für Bio und Geowissenschaften, IBG 1 Biotechnologie, Forschungszentrum Julich, D 52425 Julich, Germany
    J Biotechnol 163:166-78. 2013
  94. pmc Natural terpenes prevent mitochondrial dysfunction, oxidative stress and release of apoptotic proteins during nimesulide-hepatotoxicity in rats
    Brijesh Kumar Singh
    Herbal Research Section, CSIR Indian Institute of Toxicology Research, Lucknow, Uttar Pradesh, India
    PLoS ONE 7:e34200. 2012
    ..and mitochondrial dysfunction during nimesulide-induced hepatotoxicity and its attenuation by plant derived terpenes, camphene and geraniol has been explored in male Sprague-Dawley rats...
  95. pmc A new family of enzymes catalyzing the first committed step of the methylerythritol 4-phosphate (MEP) pathway for isoprenoid biosynthesis in bacteria
    Felix J Sangari
    Departamento de Biologia Molecular, Universidad de Cantabria and Instituto de Biomedicina y Biotecnología de Cantabria IBBTEC, CSIC UC IDICAN, 39011 Santander, Spain
    Proc Natl Acad Sci U S A 107:14081-6. 2010
  96. pmc Chromatographic profiles and identification of new phenolic components of Ginkgo biloba leaves and selected products
    Long Ze Lin
    Food Composition and Methods Development Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, U S Department of Agriculture, Beltsville, Maryland 20705, USA
    J Agric Food Chem 56:6671-9. 2008
    ..The detected glycosylated flavonol contents were equal to or more than 0.0008% of the dry plant material. This is the first report of the presence of more than 20 of these flavonoids in G. biloba...
  97. ncbi Remodeling the isoprenoid pathway in tobacco by expressing the cytoplasmic mevalonate pathway in chloroplasts
    Shashi Kumar
    Western Regional Research Center, Agricultural Research Service, United States Department of Agriculture, Albany, CA, USA
    Metab Eng 14:19-28. 2012
    ..Thus, we have developed an important tool to redirect metabolic fluxes in the isoprenoid biosynthesis pathway and a viable multigene strategy for engineering metabolism in plants...
  98. pmc Inactivation of sll1556 in Synechocystis strain PCC 6803 impairs isoprenoid biosynthesis from pentose phosphate cycle substrates in vitro
    Kelly Poliquin
    Department of Cell Biology and Molecular Genetics, Microbiology Building, Campus Dr, University of Maryland, College Park, MD 20742, USA
    J Bacteriol 186:4685-93. 2004
    ..Our findings are consistent with an alternate metabolic shunt for biosynthesis of isoprenoids...
  99. ncbi Volatile components of peel and leaf oils of lemon and lime species
    Marie Laure Lota
    Université de Corse, Equipe Chimie et Biomasse, UMR CNRS 6134, Route des Sanguinaires, 20000 Ajaccio, France
    J Agric Food Chem 50:796-805. 2002
    ..Four others were identified for lime leaf oils: beta-pinene/limonene; limonene/geranial/neral; limonene/linalool/citronellal; and limonene/sabinene/citronellal/linalool. These results were interpreted using principal component analysis...
  100. pmc Detection of nonsterol isoprenoids by HPLC-MS/MS
    Linda Henneman
    Academic Medical Center, University of Amsterdam, Laboratory Genetic Metabolic Diseases, Departments of Paediatrics Emma Children s Hospital and Clinical Chemistry, Amsterdam, The Netherlands
    Anal Biochem 383:18-24. 2008
    ..This method will be suitable for measuring profiles of isoprenoid intermediates in cells with compromised isoprenoid biosynthesis and for determining the specificity of potential inhibitors of the pathway...
  101. ncbi An overview of structural features of DNA and RNA complexes with saffron compounds: Models and antioxidant activity
    C D Kanakis
    Department of Science, Agricultural University of Athens, Greece
    J Photochem Photobiol B 95:204-12. 2009
    ..The IC(50) values were 95+/-1microg/mL for safranal and 18+/-1microg/mL for crocetin. The inhibition of DMCRT reached a point of 38.8%, which corresponds to a concentration of 40microg/mL...

Research Grants62

  1. Structural Basis for Isoprenoid Biosynthesis
    JOSEPH NOEL; Fiscal Year: 2006
  2. Inhibitors of isoprenoid synthesis for antibacterial therapy
    Donald T Moir; Fiscal Year: 2013
    ..In Phase II, we will examine analogs of the highest priority hits and chemically optimize the most promising of these structures to develop lead compounds for efficacy and toxicity testing in animal models. ..
  3. Biosynthesis of Microbial Isoprenoids
    David E Cane; Fiscal Year: 2013
  4. The Effect of Diet and Nutrients on the Progression and Treatment of Prostate Can
    George Thomas; Fiscal Year: 2013
    ..Among these, obesity is an increasingly important risk factor. This project will examine the role of diet in the progression of prostate cancer and as an avenue for designing new therapeutic approaches based on existing mouse models. ..
    AUDREY RAGAN ODOM; Fiscal Year: 2013
    ..falciparum genome, and identify new targets for much-needed antimalarial drug development. ..
    Inderjit Singh; Fiscal Year: 2013
    ..These studies will identify therapeutic targets for induction of myelin repair in MS and these findings should be applicable to other related neurodegenerative diseases. ..
  7. Targeting DXP Synthase in Non-mammalian Isoprenoid Biosynthesis
    FRANCINE M MORRIS; Fiscal Year: 2012
    ..The long term goal is to develop novel, potent and broad-based anti-microbial agents that also exhibit limited toxicity to the human host. ..
  8. Counter-irritation by Menthol: Molecular Targets and Role in Airway Disease
    John B Morris; Fiscal Year: 2013
    ..of the same chemical flavor and sensory additives outlawed for use in tobacco cigarettes, including irritating terpenes such as linalool...
  9. Aldo-keto reductase family 1 member B10 AKR1B10 in pancreatic carcinogenesis
    Guang Yu Yang; Fiscal Year: 2013
  10. Targeting a Unique Enzyme Mechanism in Non-Mammalian Isoprenoid Biosynthesis
    Jessica M Smith; Fiscal Year: 2013
    ..The rationale for the proposed studies is that developing strategies for selective inhibition of this enzyme will provide new tools for investigating this essential pathway in pathogens and will lead to new anti-infective agents. ..
  11. Dissecting ER-Associated Degradation of a Membrane Protein in Drosophila S2 Cells
    ..Thus, elucidating mechanisms for the ERAD of reductase may lead to new therapies that increase the effectiveness of statins and ultimately reduce the incidence of heart attacks. ..
  12. Enzymatic formation of the hydrocarbon skeletons underlying diterpenoid diversity
    REUBEN JOHN PETERS; Fiscal Year: 2013
    ..Accordingly, our studies have implications not only for providing increased access to such natural products, but also insights into potential drug targets, specifically in the widespread pathogen M. tuberculosis. ..
  13. Effects of insulin-like signaling, aging, and ubiquinone on C. elegans muscle
    Alfred L Fisher; Fiscal Year: 2013
    ..Together our project can provide insights into the roles of mitochondrial dysfunction in muscle during aging or in response to impaired ubiquinone synthesis due to medications such as statins. ..
  14. Functional analysis of a potassium sensing kinase in Bacillus subtilis
    ERIN ANN GONTANG; Fiscal Year: 2011
    GERALD KOSER; Fiscal Year: 1990
    ..DNA, RNA, cell membranes), metabolic and biosynthetic intermediates (carbohydrates, amino acids, steroids, terpenes) and coenzymes and play a crucial role in biological energy flow...
  16. Structure and Function of Biosynthetic Enzymes
    David W Christianson; Fiscal Year: 2013
  17. Total Synthesis of Anticancer Agent Strongylophorine-26 and Studies Directed to U
    Shengping Zheng; Fiscal Year: 2013
    ..Moreover, the lactone ring is necessary for activity probably because of its susceptibility to nucleophilic attack. This will be tested by modifying the lactone ring to lactam, lactol, or its seco hydroxyl acid. ..
  18. Deciphering apicoplast function during blood stage Plasmodium infection
    Ellen Yeh; Fiscal Year: 2013
    ..The proposed research and career development activities will be critical in the preparation for an academic career and provide ample opportunities for a future in independent research. ..
  19. Synthesis of Complex Terpenes
    Phil S Baran; Fiscal Year: 2013
  20. Taste psychophysics of bitter phytochemicals
    MIRIAM LINSCHOTEN; Fiscal Year: 2005
    ..Phytochemicals such as phenols, flavonoids, isoflavones, terpenes and glucosinolates have anti-oxidant and anti-carcinogenic properties and demonstrate a wide spectrum of tumor-..
  21. Enzyme-Mediated Synthesis of Functionalized Terpene Structures
    Jay D Keasling; Fiscal Year: 2010
    ..b>Terpenes, constituting one of the most diverse groups of compounds synthesized by biological systems, have been used as ..
  22. Mechanistic studies of enzymes in isoprenoid biosynthesis
    Pinghua Liu; Fiscal Year: 2013
    ..The public health benefit will result from the development of effective new treatments for drug-resistant strains of pathogens, currently of increasing concern worldwide. ..
  23. Methylerythritol Phosphate Pathway Inhibitors Targeting Gram-Negative Infections
    CHARLES TESTA; Fiscal Year: 2009
  24. Methylerythritol Phosphate Pathway-Specific Natural Products as Antibacterials
    CHARLES TESTA; Fiscal Year: 2009
    ..The pathway is not the target of any currently prescribed therapeutic, therefore these compounds and their derivatives are expected to have prolonged utility relative to subsequent generations of antibiotics presently in use. ..
  25. Defining the novel eukaryotic biology of the Apicomplexan plastid
    Ellen Yeh; Fiscal Year: 2013
    ..This work has direct and significant implications for development of novel therapeutics against these important human pathogens. ..
  26. Small Molecules that Regulate Proteasome Activity
    Chin Ho Chen; Fiscal Year: 2012
    ..abstract_text> ..
    JOSEPH NOEL; Fiscal Year: 2003
    ..Our current objective is to understand the regiochemical and stereochemical principles that govern the biosynthesis of pharmaceutically useful terpenoids. ..
  28. Synthesis of Polyketides and Terpenes
    David A Evans; Fiscal Year: 2010
    ..As a consequence, organic synthesis is a critical discipline that continues to have an important impact on the fields of both medicine and biology. ..
  29. Arthropod-Based Libraries for High Throughput Screening
    Frank Schroeder; Fiscal Year: 2009
  30. Selective P450 Oxidation Catalysts for Synthesis of Bioactive Molecules
    Rudi Fasan; Fiscal Year: 2013
    ..P450 catalysts with tailor-made regio- and stereoselectivity for hydroxylation of multiple aliphati positions in terpenes with clinically relevant anticancer and antimalarial activity...
    Skaidrite Krisans; Fiscal Year: 2004
    PHILIP PROTEAU; Fiscal Year: 2003
    ..abstract_text> ..
    J Cometto Muniz; Fiscal Year: 1999
    ..Stimuli will comprise homologous series of compounds (e.g., aldehydes, carboxylic acids, terpenes). Physicochemical properties change systematically in such series...
    GEORGE OLAH; Fiscal Year: 1993
    ..Further studies will center on rearrangement-cyclization reactions of biologically significant terpenes and on the interconversion of steroids under stable ion conditions...
  35. Molecular Mechanisms of Phthalate-induced Carcinogenesis
    Ivan Rusyn; Fiscal Year: 2007
    ..This results in a "potentiation" of a non-specific mitogen release from Kupffer cells activated by lipid-like peroxisome proliferator particles, thus accounting for a characteristic burst of proliferation in the liver. ..
    Ramachandran Nair; Fiscal Year: 1993
    ..The proposed approaches will lead to additional routes for an adequate supply of artemisinin; they also can result in the isolation of more potent derivatives of the drug by its bioconversion by the cell cultures and cell-free extracts...
    Jung Ja Kim; Fiscal Year: 2003
    ..3) High resolution structures of rat and human mevalonate kinases will be determined by X-ray crystallography. (4) Human mevalonate kinase mutants will be modeled to determine the molecular basis for mevalonic aciduria. ..
    Rodney Croteau; Fiscal Year: 2000
    ..In the final aim, transgenic Taxus systems will be engineered for overexpression of slow pathway steps using existing technologies, and the influence on the production yields of taxol, and related taxoids, will be determined. ..
    Duy Hua; Fiscal Year: 1991
    ..Once the active compounds are identified, they will be tested in vivo animal models at Dr. Matthew Suffness's laboratory, Division of Cancer Treatment, NCI or Dr. Dolores Takemoto's (Co-investigator) laboratory...
    DAVID WIEMER; Fiscal Year: 1990
    ..Ultimately, this may lead to the ability to design second generation substances with enhanced antileukemic activity, and to a better understanding of the process of tumor promotion...
    JOSEPH LANZILLO; Fiscal Year: 2000
    ..These data should establish core findings that can be extrapolated to encompass a more complete understanding of how Gb induces physiological effects deemed to be beneficial. ..
  42. Isoprenoids and aberrant sprouting in Alzheimer's disease
    Yan Zhou; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
    Harlyn Halvorson; Fiscal Year: 1991
    ..These projects are funded primarily by NSF and the NIH; additional sources of support include the Petroleum Research Fund, US Department of Agriculture, New York State, and more than six private corporations and foundations...
  44. Intracellular Localization of Protein Prenylation
    Mark Brown; Fiscal Year: 2003
    ..The second approach will employ shuttle molecules that will be developed based on prior expertise at Echelon for the intracellular delivery of phosphoinositides. ..
    ANDREW KANDUTSCH; Fiscal Year: 1990
    ..Studies of the mechanisms by which HMG-CoA reductase is regulated will include measurements of inactive reductase, of its mRNA and of the concentrations of regulatory oxysterols in synchronized cells separated by centrifugal elutriation...
  46. Engineering Terpene Synthases for Increased Productivity
    Jennifer Anthony; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Terpenes are the most diverse class of natural products, with 30,000 known members...
    JAMES WHITESELL; Fiscal Year: 1980
    ..This project is aimed at developing practical, laboratory syntheses for these terpenes in order that significant quantities may be available for further testing, as well as at providing synthetic ..
    THOMAS LANGAN; Fiscal Year: 1991
    ..Thus, new information regarding the processes which regulate proliferation of developing glial cells will be obtained...
    PAUL WILLIARD; Fiscal Year: 1992
    ..Positive results from this investigation will permit a more rational choice of reagents for the asymmetric synthesis of the physiologically active organic molecules...
  50. Cell Culture Production of Marine-Derived Bioactive Terpenses
    LORY SANTIAGO VAZQUEZ; Fiscal Year: 2006
    ..This project will focus on the development of a sustainable production method of terpenes from marine gorgonians...
  51. Total Synthesis of Antimalarial Kalihinol A
    Erik Meredith; Fiscal Year: 2003
    ..A pharmacophore model of related isonitrile terpenes has recently been set forth and the compounds were found to target the parasite within its blood stage by ..
  52. Heterologous Production of Eleutherobin Precursors
    Neil Renninger; Fiscal Year: 2004
    ..the clinical testing and use of new cancer compounds through the economical production of otherwise scarce terpenes. Eleutherobin and sarcodictyin A and B are cytotoxic terpenes that act in a manner analogous to very successful ..
  53. Model-Driven Strain Engineering for Isoprenoid Drug Production
    Anthony Burgard; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  54. Structure and Mechanism of Terpene Cyclases
    PAUL O MAILLE; Fiscal Year: 2004
    ..Ultimately, this knowledge will enable complex organic synthesis of biologicallv important molecules through protein engineering. ..
    CLAYTON HEATHCOCK; Fiscal Year: 2003
    ..Among these targets are discorhabdin D, cephalostatin 12, and halichlorine, compounds so rare that insufficient material is available for full scale in vivo evaluation. Through total synthesis we hope to remedy this problem. ..
    JAMES RIGBY; Fiscal Year: 2006
    ..unreadable] [unreadable]..
    REINHARD DUNKEL; Fiscal Year: 1991
    ..These extensions will enable non-experts to efficiently use INADEQUATE spectra in conjunction with the automated analysis to determine the structure of molecules such as terpenes, alkaloids, hormones, etc.
  58. Domoic Acid and Neonatal Microglia Activation
    Alejandro Mayer; Fiscal Year: 2004
    ..activated microglia cells and their mediators play in DOM-induced excitotoxic neuronal injury and thus contribute to potential novel approaches for the therapy of the neuropathology associated with Amnesic Shellfish Poisoning in humans ..
  59. Synthesis of the myrmicarin family of natural products
    Scott Snyder; Fiscal Year: 2005