polychlorinated biphenyls

Summary

Summary: Industrial products consisting of a mixture of chlorinated biphenyl congeners and isomers. These compounds are highly lipophilic and tend to accumulate in fat stores of animals. Many of these compounds are considered toxic and potential environmental pollutants.

Top Publications

  1. ncbi Levels in the U.S. population of those persistent organic pollutants (2003-2004) included in the Stockholm Convention or in other long range transboundary air pollution agreements
    Donald G Patterson
    National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, Mailstop F 17, Atlanta, Georgia 30341, USA
    Environ Sci Technol 43:1211-8. 2009
  2. pmc Prenatal concentrations of polychlorinated biphenyls, DDE, and DDT and overweight in children: a prospective birth cohort study
    Damaskini Valvi
    Centre for Research in Environmental Epidemiology, Barcelona, Spain
    Environ Health Perspect 120:451-7. 2012
  3. pmc Birth weight and prenatal exposure to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE): a meta-analysis within 12 European Birth Cohorts
    Eva Govarts
    Environmental Risk and Health, Flemish Institute for Technological Research VITO, Mol, Belgium
    Environ Health Perspect 120:162-70. 2012
  4. pmc The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants
    A M Soto
    Tufts University School of Medicine, Department of Anatomy and Cellular Biology, Boston, MA 02111, USA
    Environ Health Perspect 103:113-22. 1995
  5. pmc Low dose organochlorine pesticides and polychlorinated biphenyls predict obesity, dyslipidemia, and insulin resistance among people free of diabetes
    Duk Hee Lee
    Department of Preventative Medicine, School of Medicine, Kyungpook National University, Daegu, Korea
    PLoS ONE 6:e15977. 2011
  6. pmc Low dose of some persistent organic pollutants predicts type 2 diabetes: a nested case-control study
    Duk Hee Lee
    Department of Preventative Medicine, School of Medicine, Kyungpook National University, Daegu, Korea
    Environ Health Perspect 118:1235-42. 2010
  7. pmc Polychlorinated biphenyl-77 induces adipocyte differentiation and proinflammatory adipokines and promotes obesity and atherosclerosis
    Violeta Arsenescu
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA
    Environ Health Perspect 116:761-8. 2008
  8. pmc Organochlorine exposure and incidence of diabetes in a cohort of Great Lakes sport fish consumers
    Mary Turyk
    Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, Chicago, Illinois 60612, USA
    Environ Health Perspect 117:1076-82. 2009
  9. pmc Intrinsic human elimination half-lives of polychlorinated biphenyls derived from the temporal evolution of cross-sectional biomonitoring data from the United Kingdom
    Roland Ritter
    Safety and Environmental Technology Group, ETH Zurich, Zurich, Switzerland
    Environ Health Perspect 119:225-31. 2011
  10. ncbi Lack of an association between environmental exposure to polychlorinated biphenyls and p,p'-DDE and DNA damage in human sperm measured using the neutral comet assay
    R Hauser
    Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, Boston, MA 02115, USA
    Hum Reprod 18:2525-33. 2003

Detail Information

Publications404 found, 100 shown here

  1. ncbi Levels in the U.S. population of those persistent organic pollutants (2003-2004) included in the Stockholm Convention or in other long range transboundary air pollution agreements
    Donald G Patterson
    National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, Mailstop F 17, Atlanta, Georgia 30341, USA
    Environ Sci Technol 43:1211-8. 2009
    ..7% of persons aged 12 years and older (90th percentile: 8.3 ng/g lipid, 95% CI: <LOD-13.0 ng/g lipid). Dieldrin was detected in 87.2% of persons aged 12 years and older (95th percentile: 18.9 ng/g lipid, 95% CI: 15.8-24.5 ng/g lipid)...
  2. pmc Prenatal concentrations of polychlorinated biphenyls, DDE, and DDT and overweight in children: a prospective birth cohort study
    Damaskini Valvi
    Centre for Research in Environmental Epidemiology, Barcelona, Spain
    Environ Health Perspect 120:451-7. 2012
    ..Recent experimental evidence suggests that prenatal exposure to endocrine-disrupting chemicals (EDCs) may increase postnatal obesity risk and that these effects may be sex or diet dependent...
  3. pmc Birth weight and prenatal exposure to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE): a meta-analysis within 12 European Birth Cohorts
    Eva Govarts
    Environmental Risk and Health, Flemish Institute for Technological Research VITO, Mol, Belgium
    Environ Health Perspect 120:162-70. 2012
    ..prenatal eXposure to the development of obesity later in life) projects, we examined the hypothesis that the combination of polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE) adversely affects birth weight.
  4. pmc The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants
    A M Soto
    Tufts University School of Medicine, Department of Anatomy and Cellular Biology, Boston, MA 02111, USA
    Environ Health Perspect 103:113-22. 1995
    ....
  5. pmc Low dose organochlorine pesticides and polychlorinated biphenyls predict obesity, dyslipidemia, and insulin resistance among people free of diabetes
    Duk Hee Lee
    Department of Preventative Medicine, School of Medicine, Kyungpook National University, Daegu, Korea
    PLoS ONE 6:e15977. 2011
    ..The current study examined if low dose POPs predicted future adiposity, dyslipidemia, and insulin resistance among controls without diabetes in that study...
  6. pmc Low dose of some persistent organic pollutants predicts type 2 diabetes: a nested case-control study
    Duk Hee Lee
    Department of Preventative Medicine, School of Medicine, Kyungpook National University, Daegu, Korea
    Environ Health Perspect 118:1235-42. 2010
    ..Low doses of some persistent organic pollutants (POPs) associate cross-sectionally with type 2 diabetes, whereas associations with high POP exposures are inconsistent...
  7. pmc Polychlorinated biphenyl-77 induces adipocyte differentiation and proinflammatory adipokines and promotes obesity and atherosclerosis
    Violeta Arsenescu
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA
    Environ Health Perspect 116:761-8. 2008
    ..Highly prevalent coplanar polychlorinated biphenyls (PCBs) such as 3,3',4,4'-tetrachlorobiphenyl (PCB-77) accumulate in adipose tissue because of their ..
  8. pmc Organochlorine exposure and incidence of diabetes in a cohort of Great Lakes sport fish consumers
    Mary Turyk
    Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, Chicago, Illinois 60612, USA
    Environ Health Perspect 117:1076-82. 2009
    ..human exposure to persistent organic pollutants (POPs) such as p,p'-diphenyldichloroethene (DDE) and polychlorinated biphenyls (PCBs)...
  9. pmc Intrinsic human elimination half-lives of polychlorinated biphenyls derived from the temporal evolution of cross-sectional biomonitoring data from the United Kingdom
    Roland Ritter
    Safety and Environmental Technology Group, ETH Zurich, Zurich, Switzerland
    Environ Health Perspect 119:225-31. 2011
    ..However, estimates of intrinsic elimination at background levels are required for risk assessments for the general population...
  10. ncbi Lack of an association between environmental exposure to polychlorinated biphenyls and p,p'-DDE and DNA damage in human sperm measured using the neutral comet assay
    R Hauser
    Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, Boston, MA 02115, USA
    Hum Reprod 18:2525-33. 2003
    Chlorinated organic chemicals, such as polychlorinated biphenyls (PCB), hexachlorobenzene (HCB), dichlorodiphenyl trichloroethane (DDT), and dichlorodiphenyl dichloroethene (DDE, the most stable daughter compound of DDT) are persistent ..
  11. pmc Prenatal organochlorine exposure and behaviors associated with attention deficit hyperactivity disorder in school-aged children
    Sharon K Sagiv
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 171:593-601. 2010
    ..76, 95% confidence interval: 1.06, 2.92) and a similar relation for p,p'-DDE. These results support an association between low-level prenatal organochlorine exposure and ADHD-like behaviors in childhood...
  12. pmc Serum dioxins and polychlorinated biphenyls are associated with growth among Russian boys
    Jane S Burns
    Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Building I, Room 1404E, Boston, MA 02115, USA
    Pediatrics 127:e59-68. 2011
    We evaluated the associations of serum dioxins and polychlorinated biphenyls (PCBs) with longitudinally assessed growth measurements among peripubertal Russian boys.
  13. pmc Association between type 2 diabetes and exposure to persistent organic pollutants
    Riikka Airaksinen
    Department of Environmental Health, National Institute for Health and Welfare, Kuopio, Finland
    Diabetes Care 34:1972-9. 2011
    ..The purpose of this cross-sectional study is to examine the association between type 2 diabetes and POP exposure in the Helsinki Birth Cohort Study...
  14. ncbi Maternal levels of dichlorodiphenyl-dichloroethylene (DDE) may increase weight and body mass index in adult female offspring
    W Karmaus
    Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, 800 Sumter Street, Columbia, SC 29208 0001, USA
    Occup Environ Med 66:143-9. 2009
    To investigate the effect of prenatal exposure to polychlorinated biphenyls (PCBs) and dichlorodiphenyl-dichloroethylene (DDE) on weight, height and body mass index (BMI) in adult female offspring of the Michigan fisheater cohort ..
  15. pmc Polychlorinated biphenyls and organochlorine pesticides in plasma predict development of type 2 diabetes in the elderly: the prospective investigation of the vasculature in Uppsala Seniors (PIVUS) study
    Duk Hee Lee
    Department of Preventative Medicine, Kyungpook National University, Daegu, Korea
    Diabetes Care 34:1778-84. 2011
    ..However, evidence from prospective studies is sparse. This study was performed to evaluate prospective associations of type 2 diabetes with selected POPs among the elderly...
  16. pmc Mechanistic basis of resistance to PCBs in Atlantic tomcod from the Hudson River
    Isaac Wirgin
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    Science 331:1322-5. 2011
    ..of vertebrate populations to contaminants, including Atlantic tomcod from the Hudson River (HR) to polychlorinated biphenyls (PCBs), is unknown...
  17. pmc Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity
    Isaac N Pessah
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Pharmacol Ther 125:260-85. 2010
    ....
  18. pmc Partition of environmental chemicals between maternal and fetal blood and tissues
    Larry L Needham
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Sci Technol 45:1121-6. 2011
    ..Although the environmental chemicals examined pass through the placenta and are excreted into milk, partitions between maternal and fetal samples are not uniform...
  19. pmc The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds
    Martin van den Berg
    World Health Organization Collaborating Centre for Research on Environmental Health Risk Assessment and Institute for Risk Assessment Sciences, Science and University Medical Center, Universiteit Utrecht, The Netherlands
    Toxicol Sci 93:223-41. 2006
    ..in Geneva during which the toxic equivalency factors (TEFs) for dioxin-like compounds, including some polychlorinated biphenyls (PCBs), were reevaluated...
  20. pmc Prenatal exposure to organohalogens, including brominated flame retardants, influences motor, cognitive, and behavioral performance at school age
    Elise Roze
    Division of Neonatology, Beatrix Children s Hospital, University Medical Center Groningen, The Netherlands
    Environ Health Perspect 117:1953-8. 2009
    ..Organohalogen compounds (OHCs) are known to have neurotoxic effects on the developing brain...
  21. pmc Exposure to PCBs and p,p'-DDE and human sperm chromatin integrity
    Anna Rignell-Hydbom
    Department of Occupational and Environmental Medicine, Lund University Hospital, Lund, Sweden
    Environ Health Perspect 113:175-9. 2005
    Persistent organochlorine pollutants (POPs) such as polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (p,p'-DDE), the major metabolite of dichlorodiphenyltrichloroethane (DDT), are stable lipophilic compounds widely ..
  22. ncbi Relationships between polychlorinated biphenyls and health status in harbor porpoises (Phocoena phocoena) stranded in the United Kingdom
    Paul D Jepson
    Institute of Zoology, Zoological Society of London, Regent s Park, London NW1 4RY, United Kingdom
    Environ Toxicol Chem 24:238-48. 2005
    ....
  23. pmc Polychlorinated biphenyl (PCB) exposure and diabetes: results from the Anniston Community Health Survey
    Allen E Silverstone
    State University of New York Upstate Medical University, Syracuse, New York 13210, USA
    Environ Health Perspect 120:727-32. 2012
    b>Polychlorinated biphenyls (PCBs) manufactured in Anniston, Alabama, from 1929 to 1971 caused significant environmental contamination. The Anniston population remains one of the most highly exposed in the world.
  24. ncbi Obesity and persistent organic pollutants: possible obesogenic effect of organochlorine pesticides and polychlorinated biphenyls
    Eveline Dirinck
    Department of Endocrinology, Diabetology and Clinical Pharmacology, Antwerp University Hospital and University of Antwerp, Antwerp, Belgium
    Obesity (Silver Spring) 19:709-14. 2011
    ..Combined, these results suggest that the diabetogenic effect of low-dose exposure to POPs might be more complicated than a simple obesogenic effect...
  25. pmc Lead and PCBs as risk factors for attention deficit/hyperactivity disorder
    Paul A Eubig
    Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois at Urbana Champaign, Urbana, Illinois 61802, USA
    Environ Health Perspect 118:1654-67. 2010
    ..In this review we present evidence that environmental chemicals, particularly polychlorinated biphenyls (PCBs) and lead, are associated with deficits in many neurobehavioral functions that are also impaired ..
  26. ncbi Residues of polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs) and organochlorine pesticides in organically-farmed vegetables
    Azza Zohair
    Faculty of Specific Education, Home Economics Science Department, Menufiya Universty, Ashmoun, 32811 Menufiya, Egypt
    Chemosphere 63:541-53. 2006
    The residues of polyaromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) in soils from organic farms and their uptake by four varieties of organic-produced potatoes and three varieties of ..
  27. ncbi Developmental aspects of environmental neurotoxicology: lessons from lead and polychlorinated biphenyls
    Gerhard Winneke
    Division of Neurobehavioral Toxicology, Medical Institute of Environmental Hygiene, Heinrich Heine Universitat, Auf m Hennekamp 50, D 40225, Dusseldorf, Germany
    J Neurol Sci 308:9-15. 2011
    ..However, for only few of these, namely inorganic lead, arsenic, organic mercury and polychlorinated biphenyls (PCBs), human evidence is available to suggest that these may cause neurodevelopmental adversity and may,..
  28. pmc Fate and complex pathogenic effects of dioxins and polychlorinated biphenyls in obese subjects before and after drastic weight loss
    Min Ji Kim
    INSERM, UMR S, Universite Paris Descartes, Centre Universitaire des Saints Peres, France
    Environ Health Perspect 119:377-83. 2011
    ..In humans, persistent organic pollutants (POPs) are stored primarily in adipose tissue. Their total body burden and their contribution to obesity-associated diseases remain unclear...
  29. ncbi Plasma polychlorobiphenyl and organochlorine pesticide level and risk of major lymphoma subtypes
    P Cocco
    Department of Public Health, Occupational Health Section, Asse Didattico Policlinico Universitario, SS 554, Km 4, 500, 09042 Monserrato Cagliari, Italy
    Occup Environ Med 65:132-40. 2008
    ..There is conflicting epidemiological evidence concerning an increase in risk of non-Hodgkin's lymphoma (NHL) associated with elevated blood levels of persistent organochlorine (OC) pesticides and polychlorobiphenyls (PCBs)...
  30. ncbi Perinatal exposure to polychlorinated biphenyls differentially affects cerebellar development and motor functions in male and female rat neonates
    K Nguon
    Department of Psychiatry, Brigham and Women s Hospital, Boston, MA, USA
    Cerebellum 4:112-22. 2005
    Perinatal exposure to polychlorinated biphenyls (PCBs) interacts with genetics and impacts the course of the central nervous system (CNS) development in both humans and animals...
  31. pmc Relationship of thyroid hormone levels to levels of polychlorinated biphenyls, lead, p,p'- DDE, and other toxicants in Akwesasne Mohawk youth
    Lawrence M Schell
    Department of Anthropology, University at Albany, State University of New York, Albany, New York 12222, USA
    Environ Health Perspect 116:806-13. 2008
    It is well documented that acute exposure to high levels of persistent organic pollutants, such as polychlorinated biphenyls (PCBs), p,p'-dichlorophenyldichloroethylene (p,p'-DDE), and hexachlorobenzene (HCB), can affect human health ..
  32. ncbi Decreased human semen quality and organochlorine compounds in blood
    Jan W Dallinga
    Department of Health Risk Analysis and Toxicology, Faculty of Health Sciences, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Hum Reprod 17:1973-9. 2002
    ..Various studies have been performed in which potential effects of xenoestrogens on fertility or sperm parameters were investigated by comparing groups of subjects exposed to different levels of these chemicals...
  33. pmc Association of low-dose exposure to persistent organic pollutants with global DNA hypomethylation in healthy Koreans
    Keon Yeop Kim
    Department of Preventative Medicine, School of Medicine, Kyungpook National University, Daegu, Korea
    Environ Health Perspect 118:370-4. 2010
    ..Whether these associations extend to a population with much lower concentrations of POPs is not known...
  34. pmc Increased risk of diabetes and polychlorinated biphenyls and dioxins: a 24-year follow-up study of the Yucheng cohort
    Shu Li Wang
    Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Miaoli, Taiwan
    Diabetes Care 31:1574-9. 2008
    b>Polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs) are important and persistent organic pollutants (POPs) in humans...
  35. ncbi ortho-substituted PCB95 alters intracellular calcium signaling and causes cellular acidification in PC12 cells by an immunophilin-dependent mechanism
    P W Wong
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis 95616, USA
    J Neurochem 76:450-63. 2001
    ....
  36. pmc Apparent half-lives of dioxins, furans, and polychlorinated biphenyls as a function of age, body fat, smoking status, and breast-feeding
    Meghan O Grady Milbrath
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109 2029, USA
    Environ Health Perspect 117:417-25. 2009
    ....
  37. pmc An exploratory study of diabetes in a First Nation community with respect to serum concentrations of p,p'-DDE and PCBs and fish consumption
    Aline Philibert
    CINBIOSE, Universite du Quebec a Montreal UQAM, Montreal, Quebec, Canada
    Int J Environ Res Public Health 6:3179-89. 2009
    ..These findings support the hypothesis that environmental exposure to elevated p,p'-DDE and PCBs is associated with increased risk of diabetes. Consumption of trout and white fish may be beneficial to reduce risk...
  38. pmc Birth delivery mode modifies the associations between prenatal polychlorinated biphenyl (PCB) and polybrominated diphenyl ether (PBDE) and neonatal thyroid hormone levels
    Julie B Herbstman
    Columbia Center for Children s Environmental Health, Department of Environmental Health Sciences, Columbia Mailman School of Public Health, New York, New York 10032, USA
    Environ Health Perspect 116:1376-82. 2008
    Developing infants may be especially sensitive to hormone disruption from chemicals including polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs).
  39. ncbi White adipose tissue: storage and effector site for environmental pollutants
    D Mullerova
    Institute of Public Health, Medical Faculty in Pilsen, Charles University, Pilsen, Czech Republic
    Physiol Res 56:375-81. 2007
    ..By modulating WAT differentiation, metabolism and function, the POPs could affect not only the physiological role of WAT, but they may also influence the development of obesity-associated diseases...
  40. pmc Exposure to p,p'-DDE: a risk factor for type 2 diabetes
    Anna Rignell-Hydbom
    Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, University Hospital, Lund, Sweden
    PLoS ONE 4:e7503. 2009
    ..Reversed causality can however not be excluded. The aim of this case-control study was to evaluate whether POPs concentration is a risk factor for type 2 diabetes...
  41. pmc Multiple environmental chemical exposures to lead, mercury and polychlorinated biphenyls among childbearing-aged women (NHANES 1999-2004): Body burden and risk factors
    Marcella Remer Thompson
    Superfund Research Program, Brown University, Providence, Rhode Island, USA
    Environ Res 121:23-30. 2013
    Lead, mercury and polychlorinated biphenyls (PCBs) are neurotoxicants with intergenerational health consequences from maternal body burden and gestational exposures...
  42. ncbi Microbial transformation and degradation of polychlorinated biphenyls
    Jim A Field
    Department of Chemical and Environmental Engineering, University of Arizona, PO Box 210011, Tucson, AZ 85721, USA
    Environ Pollut 155:1-12. 2008
    This paper reviews the potential of microorganisms to transform polychlorinated biphenyls (PCBs). In anaerobic environments, higher chlorinated biphenyls can undergo reductive dehalogenation...
  43. pmc Crystallographic analysis of a hydroxylated polychlorinated biphenyl (OH-PCB) bound to the catalytic estrogen binding site of human estrogen sulfotransferase
    Sergei Shevtsov
    Pharmacogenetic Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 111:884-8. 2003
    Certain hydroxylated polychlorinated biphenyls (OH-PCBs) inhibit the human estrogen sulfotransferase (hEST) at subnanomolar concentrations, suggesting a possible pathway for PCB toxicity due to environmental exposure in humans...
  44. ncbi A strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes: results from the National Health and Examination Survey 1999-2002
    Duk Hee Lee
    Department of Preventive Medicine, School of Medicine, Kyungpook University, 101 Dongin dong, Jung Gu, Daegu, Korea 700 422
    Diabetes Care 29:1638-44. 2006
    ..Low-level exposure to some persistent organic pollutants (POPs) has recently become a focus because of their possible link with the risk of diabetes...
  45. ncbi Persistent organic pollutants in soils and sediments from James Ross Island, Antarctica
    Jana Klanova
    RECETOX, Masaryk University, Kamenice 126 3, 625 00 Brno, Czech Republic
    Environ Pollut 152:416-23. 2008
    ....
  46. ncbi Intra-individual variations and time trends 1991-2001 in human serum levels of PCB, DDE and hexachlorobenzene
    Lars Hagmar
    Division of Occupational and Environmental Medicine and Psychiatric Epidemiology, Department of Laboratory Medicine, Lund University Hospital, SE 221 85 Lund, Sweden
    Chemosphere 64:1507-13. 2006
    ....
  47. ncbi Prenatal exposure to polychlorinated biphenyls and dioxins from the maternal diet may be associated with immunosuppressive effects that persist into early childhood
    Solvor Berntsen Stølevik
    Norwegian Institute of Public Health, NO 0403 Oslo, Norway
    Food Chem Toxicol 51:165-72. 2013
    We investigated whether prenatal exposure from the maternal diet to the toxicants polychlorinated biphenyls (PCBs) and dioxins is associated with the development of immune-related diseases in childhood...
  48. ncbi Exposure to PCB and p, p'-DDE in European and Inuit populations: impact on human sperm chromatin integrity
    M Spano
    Section of Toxicology and Biomedical Sciences, BIOTEC MED, ENEA Casaccia, 00060 Rome, Italy
    Hum Reprod 20:3488-99. 2005
    Persistent organochlorine pollutants (POP), such as polychlorinated biphenyls (PCB) and dichlorodiphenyldichloroethylene (p, p'-DDE), are widely found in the environment and considered potential endocrine-disrupting compounds (EDC)...
  49. pmc Response inhibition and error monitoring during a visual go/no-go task in inuit children exposed to lead, polychlorinated biphenyls, and methylmercury
    Olivier Boucher
    Centre de Recherche du Centre Hospitalier Universitaire de Québec, Quebec, Canada
    Environ Health Perspect 120:608-15. 2012
    Lead (Pb) and polychlorinated biphenyls (PCBs) are neurotoxic contaminants that have been related to impairment in response inhibition.
  50. pmc Reproductive hormone levels in men exposed to persistent organohalogen pollutants: a study of inuit and three European cohorts
    Aleksander H Giwercman
    Molecular Reproductive Medicine Research Unit, Department of Clinical Sciences, Malmo University Hospital, Lund University, Malmo, Sweden
    Environ Health Perspect 114:1348-53. 2006
    ..Persistent organohalogen pollutant (POP) exposure may have a negative impact on reproductive function. The objective of this study was to assess the impact of POP exposure on the male hypothalamo-pituitary-gonadal axis...
  51. ncbi The effect of in utero exposure to dioxins and polychlorinated biphenyls on reproductive development in eight year-old children
    Pen Hua Su
    Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan
    Environ Int 39:181-7. 2012
    ..on the effects of in utero exposure to polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs) on thyroid function and growth hormone concentrations at birth and in two and five year-old ..
  52. ncbi Prenatal exposure to polychlorinated biphenyls and dioxins is associated with increased risk of wheeze and infections in infants
    Solvor Berntsen Stølevik
    Norwegian Institute of Public Health, NO 0403 Oslo, Norway
    Food Chem Toxicol 49:1843-8. 2011
    ..We here report on the environmental pollutants polychlorinated biphenyls (PCBs) and dioxins, as well as acrylamide generated in food during heat treatment...
  53. ncbi Population genetic structure of a nonmigratory estuarine fish (Fundulus heteroclitus) across a strong gradient of polychlorinated biphenyl contamination
    Shaun A Roark
    Department of Zoology, Miami University, Oxford, Ohio 45056, USA
    Environ Toxicol Chem 24:717-25. 2005
    ..sites exhibit heritable resistance to some of the toxic effects of early life-stage exposure to polychlorinated biphenyls (PCBs)...
  54. pmc Accumulation of polychlorinated biphenyls in adipocytes: selective targeting to lipid droplets and role of caveolin-1
    Sophie Bourez
    Institut des Sciences de la Vie, UCLouvain, Louvain la Neuve, Belgium
    PLoS ONE 7:e31834. 2012
    b>Polychlorinated biphenyls (PCBs) are persistent environmental pollutants that preferentially accumulate in lipid-rich tissues of contaminated organisms...
  55. ncbi Developmental exposure to polychlorinated biphenyls 52, 138 or 180 affects differentially learning or motor coordination in adult rats. Mechanisms involved
    J Boix
    Laboratory of Neurobiology, Centro de Investigacion Principe Felipe, Avda Autopista del Saler, 16, 46012 Valencia, Spain
    Neuroscience 167:994-1003. 2010
    Exposure to polychlorinated biphenyls (PCBs) during pregnancy and lactation leads to cognitive impairment and motor disorders in children by mechanisms which remain unknown...
  56. ncbi Distribution of organobrominated and organochlorinated contaminants in Belgian human adipose tissue
    Adrian Covaci
    Toxicological Center, University of Antwerp, Wilrijk, 2610, Belgium
    Environ Res 88:210-8. 2002
    ..20 recent human adipose tissues from Belgium and compared them to other organohalogen compounds such as polychlorinated biphenyls (PCBs), hexachlorobenzene, 2,2-bis(4-chlorophenyl)-1,1,1-trichloroethane (p,p'-DDT), and its metabolite, ..
  57. ncbi Glutathione transferase polymorphisms and risk of endometriosis associated with polychlorinated biphenyls exposure in Italian women: a gene-environment interaction
    Susanna Vichi
    Department of Environment and Primary Prevention, Unit of Mechanisms of Toxicity, Italian National Institute for Health, Rome, Italy
    Fertil Steril 97:1143-51.e1-3. 2012
    ..between glutathione transferase (GST) gene polymorphisms (GSTM1, GSTT1, GSTP1, and GSTA1) and serum polychlorinated biphenyls (PCBs) levels...
  58. ncbi Determination of chlorinated pesticides, polychlorinated biphenyls, and polybrominated diphenyl ethers in human milk from Bizerte (Tunisia) in 2010
    Sihem Ben Hassine
    Laboratory of Environmental Analytical Chemistry 05 UR 12 03, University of Carthage, 7021 Zarzouna, Tunisia
    Chemosphere 89:369-77. 2012
    Thirty persistent organohalogen compounds including organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), and polybrominated diphenyl ethers (PBDEs) were determined in breast milk samples (n=36) of primipara and multipara ..
  59. pmc Polychlorinated biphenyls disrupt intestinal integrity via NADPH oxidase-induced alterations of tight junction protein expression
    Yean Jung Choi
    Department of Neurosurgery, University of Kentucky, Lexington, 40536, USA
    Environ Health Perspect 118:976-81. 2010
    b>Polychlorinated biphenyls (PCBs) are widely distributed environmental toxicants that contribute to numerous disease states...
  60. pmc Plasma organochlorine levels and risk of non-Hodgkin lymphoma in the Nurses' Health Study
    Francine Laden
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 19:1381-4. 2010
    Numerous studies have reported positive associations of environmental exposure to polychlorinated biphenyls (PCB) and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) with the risk of non-Hodgkin lymphoma (NHL)...
  61. ncbi Correcting serum concentrations of organochlorine compounds by lipids: alternatives to the organochlorine/total lipids ratio
    Miquel Porta
    Institut Municipal d Investigació Mèdica Hospital del Mar, E 08003 Barcelona, Catalonia, Spain
    Environ Int 35:1080-5. 2009
    ..Our aim was to analyze the relationship between serum OC and TL in patients with pancreatic ductal adenocarcinoma (PDA), and to explore several alternatives to perform the OC lipid correction...
  62. ncbi Environmental exposure to dioxins and polychlorinated biphenyls reduce levels of gonadal hormones in newborns: results from the Duisburg cohort study
    Yuguang Cao
    Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Int J Hyg Environ Health 211:30-9. 2008
    ..axis (HPG) is being discussed as underlying developmental adversity of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs). This study was done to evaluate effects related to the HPG axis.
  63. ncbi Prenatal pesticide and PCB exposures and birth outcomes
    Mary S Wolff
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Pediatr Res 61:243-50. 2007
    Evidence is inconsistent or poorly understood for links between polychlorinated biphenyls (PCBs), 1,1'-dichloro-2,2'-bis(4-chlorophenyl)ethylene (DDE), and organophosphate (OP) pesticides and adverse pregnancy outcomes, although they are ..
  64. pmc Non-dioxin-like polychlorinated biphenyls and risk of endometriosis
    Britton Trabert
    University of Washington, Seattle, Washington, USA
    Environ Health Perspect 118:1280-5. 2010
    ..Environmental contaminants, including polychlorinated biphenyls (PCBs), are hypothesized to contribute to endometriosis risk through effects on steroid hormones.
  65. pmc Perinatal exposure to polychlorinated biphenyls alters social behaviors in rats
    Banafsheh Jolous-Jamshidi
    Department of Biological Sciences, Bowling Green State University, Bowling Green, OH 43403 0208, USA
    Toxicol Lett 199:136-43. 2010
    Perinatal exposure to polychlorinated biphenyls (PCBs) leads to significant alterations of neural and hormonal systems. These alterations have been shown to impair motor and sensory development...
  66. pmc Organochlorines in Swedish women: determinants of serum concentrations
    Anders Wicklund Glynn
    Swedish National Food Administration, Uppsala, Sweden
    Environ Health Perspect 111:349-55. 2003
    ..This shows that the studied organochlorines should not be treated as a homogeneous group of compounds in epidemiologic studies...
  67. pmc Assaying organochlorines in archived serum for a large, long-term cohort: implications of combining assay results from multiple laboratories over time
    Robert I Sholtz
    Child Health and Development Studies, Public Health Institute, Berkeley, CA 94709, USA
    Environ Int 37:709-14. 2011
    ..We sought to determine whether we could successfully combine assay results for DDT-related compounds and polychlorinated biphenyls (PCBs) in serum from the same birth cohort obtained from different laboratories over time...
  68. pmc Polychlorinated biphenyl exposure and neuropsychological status among older residents of upper Hudson River communities
    Edward F Fitzgerald
    Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, State University of New York, One University Place, Rensselaer, NY 12144, USA
    Environ Health Perspect 116:209-15. 2008
    b>Polychlorinated biphenyls (PCBs) may accelerate the cognitive and motor dysfunction found in normal aging, but few studies have examined these outcomes and PCB exposure among older adults.
  69. ncbi Maternal exposure to high levels of dioxins in relation to birth weight in women affected by Yusho disease
    Kiyomi Tsukimori
    Department of Obstetrics, Fukuoka Children s Hospital, Japan
    Environ Int 38:79-86. 2012
    ..exposure to polychlorinated dibenzo-p-dioxin (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) with decreased birth weight in humans have produced conflicting results...
  70. ncbi Prenatal exposures to persistent and non-persistent organic compounds and effects on immune system development
    Irva Hertz-Picciotto
    Center for Children s Environmental Health and Department of Public Health Sciences, University of California, Davis, CA 95616, USA
    Basic Clin Pharmacol Toxicol 102:146-54. 2008
    ....
  71. ncbi Serum levels of polychlorinated biphenyls in Mexican women and breast cancer risk
    Rogelio Recio-Vega
    Centro de Investigacion Biomedica, Facultad de Medicina, Unidad Torreón, Universidad Autonoma de Coahuila, Mexico
    J Appl Toxicol 31:270-8. 2011
    ..This study was designed to evaluate the relation between polychlorinated biphenyls (PCB) exposure and breast cancer risk in Mexican women. We recruited 140 women from the General Hospital...
  72. ncbi Polychlorinated biphenyls and thyroid hormone serum concentrations among people living in a highly polluted area: a cross-sectional population-based study
    Francesco Donato
    Department of Experimental and Applied Medicine, Institute of Hygiene, Epidemiology and Public Health, University of Brescia, Viale Europa 11, Brescia, Italy
    Environ Res 108:380-6. 2008
    b>Polychlorinated biphenyls (PCBs) may interact with several thyroid functions. Severe environmental pollution by PCBs has been observed in Brescia, Italy, due to the presence of a factory that produced these compounds until 1984.
  73. ncbi Strategies for bioremediation of polychlorinated biphenyls
    Yoshiyuki Ohtsubo
    Department of Environmental Life Sciences, Graduate School of Life Sciences, Tohoku University, 2 1 1 Katahira, Sendai, 980 8577, Japan
    Appl Microbiol Biotechnol 65:250-8. 2004
    b>Polychlorinated biphenyls (PCBs) are serious environmental pollutants that threaten both the natural ecosystem and human health...
  74. pmc The effect of lipid adjustment on the analysis of environmental contaminants and the outcome of human health risks
    Audrey J Gaskins
    Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Schriver National Institute of Child Health and Human Development, NIH, Rockville, MD, USA
    Methods Mol Biol 580:371-81. 2009
    ..four statistical models (unadjusted, standardized, adjusted, and two-stage) for the analysis of polychlorinated biphenyls (PCBs) exposure, serum lipids, and health outcome risk...
  75. ncbi Serum hormones in boys prenatally exposed to polychlorinated biphenyls and dibenzofurans
    Ping Chi Hsu
    Department of Safety, Health and Environmental Engineering, National Kaohsiung First University of Science and Technology, Kaohsiung, Taiwan
    J Toxicol Environ Health A 68:1447-56. 2005
    b>Polychlorinated biphenyls (PCBs) and dibenzofurans (PCDFs) are persistent environmental pollutants shown to adversely interact with several functions of the endocrine system...
  76. pmc Predictors of serum dioxins and PCBs among peripubertal Russian boys
    Jane S Burns
    Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 117:1593-9. 2009
    Although sources and routes of exposure to dioxins and polychlorinated biphenyls (PCBs) have been studied, information regarding exposure among children is limited...
  77. ncbi The use of a non-lethal tool for evaluating toxicological hazard of organochlorine contaminants in Mediterranean cetaceans: new data 10 years after the first paper published in MPB
    M Cristina Fossi
    Department of Environmental Sciences, Siena University, Via delle Cerchia 3, Via Mattioli 4, 53100 Siena, Italy
    Mar Pollut Bull 46:972-82. 2003
    ..delphis. These results suggest that BPMO induction may be an early sign of exposure to organochlorine EDCs and can be used for periodic monitoring of Mediterranean marine mammal toxicological status...
  78. ncbi Calculation of serum "total lipid" concentrations for the adjustment of persistent organohalogen toxicant measurements in human samples
    John T Bernert
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE Atlanta, Georgia 30341, United States
    Chemosphere 68:824-31. 2007
    Persistent organohalogen toxicants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin or polychlorinated biphenyls measured in human serum are often expressed on a lipid weight basis, most commonly by dividing the toxicants' concentration by ..
  79. ncbi A food chain model to predict the levels of lipophilic organic contaminants in humans
    Gertje Czub
    Baltic Sea Research Institute, Rostock, Germany
    Environ Toxicol Chem 23:2356-66. 2004
    ..This suggests that ACC-HUMAN is a useful tool for predicting human exposure to bioaccumulative organic compounds. It can be linked easily to existing multimedia fate and transport models...
  80. ncbi Mechanisms involved in the neurotoxic effects of environmental toxicants such as polychlorinated biphenyls and brominated flame retardants
    Frode Fonnum
    Department of Biochemistry, Institute for Basal Medicine, University of Oslo, Oslo, Norway
    J Neurochem 111:1327-47. 2009
    ..Approximately 1.2 million metric tons of polychlorinated biphenyls (PCBs) have been produced and about 30% have been discharged to the environment...
  81. ncbi Concentrations of polychlorinated biphenyls in indoor air and polybrominated diphenyl ethers in indoor air and dust in Birmingham, United Kingdom: implications for human exposure
    Stuart Harrad
    Division of Environmental Health and Risk Management, Public Health Building, School of Geography, Earth, and Environmental Sciences, University of Birmingham, Birmingham, B15 2TT, United Kingdom
    Environ Sci Technol 40:4633-8. 2006
    Polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) were measured in air (using PUF disk passive samplers) in 31 homes, 33 offices, 25 cars, and 3 public microenvironments...
  82. ncbi Gene expression profiling in rat cerebellum following in utero and lactational exposure to mixtures of methylmercury, polychlorinated biphenyls and organochlorine pesticides
    B K Padhi
    Environment and Occupational Toxicology Division, HECSB, Health Canada, Tunney s Pasture, Ottawa, Ontario K1A 0L2, Canada
    Toxicol Lett 176:93-103. 2008
    ..of Canadian arctic populations, to components of the NCM administered separately (methylmercury (MeHg), polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCs)) or to the goitrogen propylthiouracyl...
  83. ncbi Neurobehavioural functions in adult progeny of rat mothers exposed to methylmercury or 2,2', 4,4', 5,5'-hexachlorobiphenyl (PCB 153) alone or their combination during gestation and lactation
    Sławomir Gralewicz
    Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, Łódź, Poland
    Int J Occup Med Environ Health 22:277-91. 2009
    Methylmercury (MeHg) and polychlorinated biphenyls (PCBs) are ubiquitous environmental pollutants. Both are neurotoxic, especially for the developing brain. The main source of human exposure to MeHg and PCBs is seafood...
  84. ncbi Endocrine disruptors and thyroid hormone physiology
    Mary Line Jugan
    Univ Paris Sud 11, Faculte de Pharmacie, Laboratoire Santé Publique Environnement, 92290 Chatenay Malabry, France
    Biochem Pharmacol 79:939-47. 2010
    ..Here, we survey the main thyroid-disrupting chemicals, such as polychlorinated biphenyls, perchlorates, and brominated flame-retardants, that are characteristic disruptors of thyroid hormone ..
  85. ncbi POP levels in breast milk and maternal serum and thyroid hormone levels in mother-child pairs from Uppsala, Sweden
    P O Darnerud
    National Food Administration, PO Box 622, 751 26 Uppsala, Sweden
    Environ Int 36:180-7. 2010
    ..When comparing studies that investigate associations between TH levels and POP levels during the perinatal stage, no obvious between-study concordance was seen regarding the critical dose for hormonal effects to occur...
  86. pmc Evidence of an age-related threshold effect of polychlorinated biphenyls (PCBs) on neuropsychological functioning in a Native American population
    Richard F Haase
    Division of Counseling Psychology, Department of Educational and Counseling Psychology, University at Albany, State University of New York, ED 220, 1400 Washington Avenue, Albany, NY 12222, USA
    Environ Res 109:73-85. 2009
    b>Polychlorinated biphenyls (PCBs) have been suspected for some time of having adverse effects on neuropsychological functioning in humans...
  87. ncbi Blood pressure and hypertension in relation to levels of serum polychlorinated biphenyls in residents of Anniston, Alabama
    Alexey Goncharov
    Department of Environmental Health Sciences, School of Public Health, University at Albany, Rensselaer, New York 12144, USA
    J Hypertens 28:2053-60. 2010
    To determine risk factors for elevated blood pressure and hypertension in residents of Anniston, Alabama who live near a plant that manufactured polychlorinated biphenyls (PCBs).
  88. ncbi Association of polychlorinated biphenyls with hypertension in the 1999-2002 National Health and Nutrition Examination Survey
    Charles J Everett
    Department of Family Medicine, Medical University of South Carolina, 295 Calhoun Street, MSC 192, Charleston, SC 9425 1920, USA
    Environ Res 108:94-7. 2008
    The association of 11 polychlorinated biphenyls (PCBs) with hypertension was investigated using the National Health and Nutrition Examination Survey (NHANES), 1999-2002...
  89. pmc Stepping backward to improve assessment of PCB congener toxicities
    L G Hansen
    Department of Veterinary Biosciences, University of Illinois, Urbana 61802, USA
    Environ Health Perspect 106:171-89. 1998
    b>Polychlorinated biphenyls (PCBs) are ubiquitous global contaminants that have been intensively investigated for three decades...
  90. ncbi Organochlorine and heavy metals in newborns: results from the Flemish Environment and Health Survey (FLEHS 2002-2006)
    Gudrun Koppen
    Environmental Risk and Health, Toxicology Group, Flemish Institute of Technological Research, 2400 Mol, Belgium
    Environ Int 35:1015-22. 2009
    ..It was concluded that the place of birth in Flanders is an important determinant of the load of pollutants measured at the start of life. This underlines the validity of human biomonitoring on (relatively) small geographical scale...
  91. ncbi Exposure to CB-153 and p,p'-DDE and male reproductive function
    A Rignell-Hydbom
    Department of Occupational and Environmental Medicine, Institute of Laboratory Medicine, Lund University Hospital, SE 221 85 Lund, Sweden
    Hum Reprod 19:2066-75. 2004
    ....
  92. ncbi Estrogen supplementation modulates effects of the endocrine disrupting pollutant PCB126 in rat bone and uterus: diverging effects in ovariectomized and intact animals
    P Monica Lind
    Karolinska Institutet, Institute of Environmental Medicine, P O Box 210, Nobels vag 13, plan 3, S 17177 Stockholm, Sweden
    Toxicology 199:129-36. 2004
    ..In conclusion, estrogen modulates PCB126 induced effects on trabecular bone, as well as several uterine parameters. These results further support an important role of estrogen on the toxic effects of PCB126 on bone and uterus...
  93. ncbi Associations of polychlorinated biphenyl exposure and endogenous hormones with diabetes in post-menopausal women previously employed at a capacitor manufacturing plant
    Victoria Persky
    University of Illinois School of Public Health, 1603 West Taylor St, Chicago, IL 60612, USA
    Environ Res 111:817-24. 2011
    ..This analysis examines relationships of serum polychlorinated biphenyls (PCBs), work exposure and endogenous hormones with self-reported history of diabetes after control for ..
  94. pmc Effect of prenatal exposure to polychlorinated biphenyls on incidence of acute respiratory infections in preschool Inuit children
    Frederic Dallaire
    Public Health Research Unit, Laval University Medical Center Centre Hospitalier Universitaire de Québec, Quebec City, Quebec, Canada
    Environ Health Perspect 114:1301-5. 2006
    We set out to assess whether environmental prenatal exposure to polychlorinated biphenyls (PCBs) is associated with incidence of acute respiratory infections in preschool Inuit children.
  95. pmc Prevalence of metabolic syndrome associated with body burden levels of dioxin and related compounds among Japan's general population
    Hirokazu Uemura
    Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Environ Health Perspect 117:568-73. 2009
    ..Environmental exposure to some persistent organic pollutants has been reported to be associated with a metabolic syndrome in the U.S. population...
  96. ncbi Dietary flavonoids modulate PCB-induced oxidative stress, CYP1A1 induction, and AhR-DNA binding activity in vascular endothelial cells
    Pachaikani Ramadass
    Molecular and Cell Nutrition Laboratory, College of Agriculture, University of Kentucky, Lexington 40546 0215, USA
    Toxicol Sci 76:212-9. 2003
    b>Polychlorinated biphenyls (PCBs), especially the more coplanar PCBs, have been shown to induce oxidative stress, various transcription factors, and subsequent inflammatory processes critical to atherosclerosis in vascular endothelial ..
  97. pmc Serum concentrations of polychlorinated biphenyls in relation to in vitro fertilization outcomes
    John D Meeker
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, USA
    Environ Health Perspect 119:1010-6. 2011
    Human exposure to polychlorinated biphenyls (PCBs) remains widespread...
  98. pmc Cord serum immunoglobulin E related to the environmental contamination of human placentas with organochlorine compounds
    E Reichrtova
    Institute of Preventive and Clinical Medicine, Bratislava, Slovakia
    Environ Health Perspect 107:895-9. 1999
    ..This association was supported by the higher incidence rate of atopic eczema cases in the population registered in the industrial region...
  99. ncbi The dioxin-like pollutant PCB 126 (3,3',4,4',5-pentachlorobiphenyl) affects risk factors for cardiovascular disease in female rats
    P Monica Lind
    Karolinska Institutet, Institute of Environmental Medicine, Nobels vag 13, plan 3, P O Box 210, 171 77 Stockholm, Sweden
    Toxicol Lett 150:293-9. 2004
    ..Of these effects of PCB 126, the increase in blood pressure was dependent on estrogen status...
  100. ncbi Carcinogenicity of "non-dioxinlike" polychlorinated biphenyls
    Stefanie Knerr
    Food Chemistry and Environmental Toxicology, University of Kaiserslautern, Kaiserslautern, Germany
    Crit Rev Toxicol 36:663-94. 2006
    Complex technical mixtures of polychlorinated biphenyls (PCBs) cause liver and thyroid neoplasms in rodents, whereas very few data are available on the carcinogenic potency of single non-dioxinlike (NDL) PCB congeners...
  101. pmc Perfluorinated compounds, polychlorinated biphenyls, and organochlorine pesticide contamination in composite food samples from Dallas, Texas, USA
    Arnold Schecter
    Division of Environmental and Occupational Health Sciences, University of Texas School of Public Health, Dallas, Texas 75390, USA
    Environ Health Perspect 118:796-802. 2010
    ..S. food by measuring perfluorinated compounds (PFCs), organochlorine pesticides, and polychlorinated biphenyls (PCBs) in composite food samples...

Research Grants67

  1. Health Effects of Lifetime Exposure to Food Contaminants
    Philippe Grandjean; Fiscal Year: 2009
    ..Postnatal exposure to MeHg and to polychlorinated biphenyls and related contaminants will be assessed by detailed questionnaire and by analysis of appropriate ..
  2. Metal and Organochlorines Exposure: Impact on Adolescent Behavior and Cognition
    Susan A Korrick; Fiscal Year: 2010
    ..3) In addition, we will assess the role of prenatal exposure to prevalent organochlorines - polychlorinated biphenyls (PCBs), dichlorodiphenyl dichloroethene (DDE), and hexachlorobenzene (HCB) -- as effect modifiers of ..
  3. Childhood Leukemia and Home Environmental Exposures
    Patricia A Buffler; Fiscal Year: 2010
    ..suspected carcinogens in house dust and indoor air, including pesticides, persistent organic compounds (polychlorinated biphenyls, polycyclic aromatic hydrocarbons, and nicotine, a surrogate for tobacco smoke), and volatile organic ..
  4. MOLECULAR MECHANISMS OF DIOXIN ACTION
    Alvaro Puga; Fiscal Year: 2013
    ..5 gene and maternal exposure to halogenated hydrocarbons, dioxins and polychlorinated biphenyls during pregnancy are the main known risk factors for these human developmental cardiac malformations...
  5. Microsomal Cytochromes P450 and their Interactions with their Redox Partners
    Lucy A Waskell; Fiscal Year: 2013
    ..routes of metabolism of a large number of environmental contaminants such as phthalates, bisphenol A, polychlorinated biphenyls (PCBs) and many currently used drugs, including chemotherapeutic agents, psychoactive compounds, and ..
  6. Novel Zebrafish Models to Study Toxicity of PCBs and Pesticides During Pregnancy
    Lisa Satterwhite; Fiscal Year: 2009
    ..in children in the Baltimore-Washington area that correlated with accidental release of dioxins and polychlorinated biphenyls (PCBs)...
  7. Early Disease Biomarkers of PCB-exposed Human Population
    Sisir K Dutta; Fiscal Year: 2010
    Current studies suggest that several human diseases involve gene-environment interaction. Polychlorinated biphenyls (PCBs) are neurodevelopmental and immunological toxicants in experimental animals treated prenatally...
  8. Dioxins and Male Pubertal Growth and Development
    Russ B Hauser; Fiscal Year: 2013
    ..contaminants that includes polychlorinated dibenzo-p- dioxins, polychlorinated dibenzofurans and polychlorinated biphenyls (PCBs), and heavy metals, specifically lead...
  9. Epidemiological Research on Autism in Jamaica - Phase II
    Mohammad H Rahbar; Fiscal Year: 2013
    ..In the proposed project, we will assess the levels of polychlorinated biphenyls (PCBs) and organochlorine (OC) pesticides in the cord-blood isolated from 144 newborns enrolled in the ..
  10. Environmental Endocrine Disruptors and Human Sperm Chromosomal Abnormalities
    Melissa Perry; Fiscal Year: 2012
    ..novel relationships between sperm aneuploidy and common environmental exposures, specifically polychlorinated biphenyls (PCBs), DDT, organophosphates (OPs), and pyrethroids (PYRs)...
  11. PHAHs and Thyroid Cancer Risk in DoDSR Cohort
    Yawei Zhang; Fiscal Year: 2013
    ..diphenyl ethers (PBDEs) and other polyhalogenated aromatic hydrocarbons (PHAHs), including polychlorinated biphenyls (PCBs) and organochlorine pesticides, are able to alter thyroid hormone homeostasis and cause thyroid ..
  12. Transgenerational Inheritance of Epigenetic Effects of Polychlorinated Biphenyls
    Charles V Vorhees; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The objective of our application is to determine if exposure to polychlorinated biphenyls (PCBs) causes epigenetic transgenerational effects...
  13. Immunotoxicity in Humans with Lifetime Exposure to Ocean Pullutants
    PHILIPPE ADAM GRANDJEAN; Fiscal Year: 2013
    ..exposure to environmental pollutants, such as methyl mercury and lipophilic contaminants, including polychlorinated biphenyls (PCBs)...
  14. CHILDHOOD DIOXIN EXPOSURE AND ENERGY HOMEOSTASIS DYSREGULATION
    Jane S Burns; Fiscal Year: 2010
    ..concentrations of polychlorinated dibenzo- p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and polychlorinated biphenyls (PCBs) with elevated serum glucose and insulin, and greater risk of type 2 diabetes mellitus (T2DM)...
  15. Genetic Susceptibility to PCB-induced Motor Dysfunction
    CHRISTINE PERDAN CURRAN; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Polychlorinated biphenyls (PCBs) are persistent organic pollutants that bio-accumulate in the food supply and resist environmental degradation...
  16. Pollutant-related diabetes in the Nurses'Health Study II
    Qi Sun; Fiscal Year: 2013
    ..Accumulating data from animal studies have linked a few POPs, such as polychlorinated biphenyls (PCBs) and p,p'- dichlorodiphenyldichloethylene (p,p'-DDE), with weight gain and insulin ..
  17. BISPHENOL A LEVELS and ENDOMETRIOSIS RISK IN REPRODUCTIVE-AGE WOMEN
    Victoria L Holt; Fiscal Year: 2012
    ..that collected urine samples and determined lipid-adjusted serum levels of organochlorine compounds and polychlorinated biphenyls. All existing data will be linked with BPA data to address the Specific Aims...
  18. The Role of Maternal Nutrition in the Teratogenesis of Alcohol in Humans
    Robert Colin Carter; Fiscal Year: 2013
    ..examining the developmental effects of in utero exposure to neurotoxic agents, most notably alcohol and polychlorinated biphenyls (PCBs)...
  19. Transgenerational epigenetic effects of PCBs on neuroendocrine systems
    Andrea C Gore; Fiscal Year: 2010
    ..We propose that EDCs such as polychlorinated biphenyls (PCBs) can effect these changes in the fetally exposed (F1) individuals through actions on steroid ..
  20. The role of heterocyclic aromatic amines in breast cancer
    Robert J Turesky; Fiscal Year: 2010
    ..to find a direct connection between exposure to environmental and dietary pollutants such as pesticides, polychlorinated biphenyls or polycyclic aromatic hydrocarbons and breast cancer...
  21. Sexually dimorphic effects of endocrine disruptors on brain &behavior
    Andrea C Gore; Fiscal Year: 2013
    ..by testing effects of perinatal exposure to a class of endocrine-disrupting chemicals, specifically polychlorinated biphenyls (PCBs), on sexually dimorphic neurobiological processes...
  22. Sirt3: A Key Player Against PCB-Induced Mitochondrial Injury
    Nukhet Aykin-Burns; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic exposure to polychlorinated biphenyls (PCBs) has been associated with a wide range of toxic effects, including hepatotoxicity, carcinogenicity, hormonal disruption, and neurotoxicity...
  23. TCDD- INDUCED CARDIOTOXICITY IN DEVELOPING ZEBRAFISH
    WARREN NO MIDDLE NAME HEIDEMAN; Fiscal Year: 2013
    ..heart defects may be caused by exposure to chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin, and polychlorinated biphenyls, commonly known as dioxin and PCBs respectively...
  24. PEDIGREE: Prenatal Environmental Determinants of InterGenerational Risk
    Mary Beth Terry; Fiscal Year: 2013
    ..Maternal pregnancy serum samples were collected during peak exposure to organochlorine pesticides and polychlorinated biphenyls in the 1960's, prior to the ban on these chemicals...
  25. PCB Disruption of Thyroid Hormone Action during Development
    ROBERT THOMAS ZOELLER; Fiscal Year: 2013
    ..provided by applicant): The long-term goals of this research are to determine the mechanisms by which polychlorinated biphenyls (PCBs) disrupt thyroid hormone (TH) action during brain development, to define the neurological ..
  26. Diabetes and Persistent Organic Pollutants
    MARY ELLEN TURYK; Fiscal Year: 2010
    ..Persistent organic pollutants (POPs) such as dioxins, polychlorinated biphenyls (PCBs), p,p'-diphenyldichloroethene (DDE), and polybrominated biphenyl ethers (PBDEs) are ..
  27. MOLECULAR BASIS OF SELECTIVE P450 2B FUNCTION
    James R Halpert; Fiscal Year: 2013
    ..CYP2B6 is of particular importance in environmental health because it is induced by pesticides and polychlorinated biphenyls (PCBs) and metabolizes insecticides, herbicides, industrial chemicals, solvents, and PCBs...
  28. Environment, Gene and Testicular Cancer Risk
    Tongzhang Zheng; Fiscal Year: 2010
    ..Several recent studies suggest that environmental exposure to organochlorines, such as polychlorinated biphenyls (PCBs) and chlorinated pesticides, may increase testicular cancer risk...
  29. Methylomic and genomic impacts of organic pollutants in Dup15q syndrome
    Janine M LaSalle; Fiscal Year: 2013
    ..Environmental toxins such as polychlorinated biphenyls (PCBs) can induce DNA hypomethylation...
  30. Epigenetic Interaction of MECP2 and Organic Pollutants in Neurodevelopment
    Janine LaSalle; Fiscal Year: 2009
    ..The widespread prevalence of POPs such as polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in the environment and their detection in human milk ..
  31. Enantioselective Metabolism Influences PCB Developmental Neurotoxicity
    Isaac N Pessah; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Developmental exposures to chiral polychlorinated biphenyls (PCBs) may cause neurodevelopmental toxicity by interfering with dendritic growth and plasticity via ..
  32. PCBs: Environmental Modulators of Human Breast Cancer Progression
    MELISSA A RUNGE MORRIS; Fiscal Year: 2010
    The development of breast cancer is a consequence of genetic risks and environmental exposures. Polychlorinated biphenyls (PCBs) are environmental contaminants that, despite their banned use, represent ongoing threats to humans due to ..
  33. PCBs worsen obesity/metabolic syndrome through 'toxic metabolic endotoxemia'
    MATTHEW C CAVE; Fiscal Year: 2013
    ..Recent research indicates a potential role for polychlorinated biphenyls (PCBs), which are persistent organic pollutants in obesity and diabetes...
  34. Molecular and Cellular Basis of PCB Developmental Neurotoxicity
    Isaac N Pessah; Fiscal Year: 2013
    Project Summary There is considerable public and regulatory concern that developmental exposures to polychlorinated biphenyls (PCBs) cause significant cognitive and behavioral deficits in children, but assessing the risks posed by these ..
  35. ENVIRONMENT CHEMICALS AND GYNECOLOGIC HEALTH (ENDO STUDY)
    Matthew Peterson; Fiscal Year: 2009
    ..The study is primarily interested in persistent organic pollutants (i.e., polychlorinated biphenyls, polybrominated diphenyl ethers, perfluorinated chemicals, and heavy metals) and lifestyle behaviors...
  36. Nutrition and Superfund Chemical Toxicity
    Bernhard Hennig; Fiscal Year: 2013
    ..The investigators will concentrate on chlorinated organics (e.g., polychlorinated biphenyls) prevalent in most Superfund sites, including those found in Kentucky...
  37. PRENATAL PCB EXPOSURE AND COGNITIVE DEVELOPMENT
    Paul Stewart; Fiscal Year: 2013
    ..States are exposed to mixtures of environmental contaminants;one of the most significant contaminants is polychlorinated biphenyls (PCBS)...
  38. Endocrine disruptor mediated activation of PXR causes dyslipidemia
    Changcheng Zhou; Fiscal Year: 2013
    ..EDCs activate PXR, including organochlorine and organophosphate pesticides, alkylphenols, phthalates, polychlorinated biphenyls, bisphenol A and its analogs...
  39. Neuropsychological & Thyroid Effects of Perfluorinated Compounds in Older Adults
    Edward Fitzgerald; Fiscal Year: 2009
    ..It builds upon an ongoing study of polychlorinated biphenyls (PCBs), polybrominated biphenylethers (PBDEs), and dioxin-like compounds (DLCs) by adding PFCs to the ..
  40. SUPERFUND TOXIC SUBSTANCES--EXPOSURE AND DISEASE
    Karl Kelsey; Fiscal Year: 2006
    ..Reproductive health is being evaluated in relation to environmental exposure to lead, mercury, polychlorinated biphenyls (PCBs) and related compounds; cardio-respiratory health is being evaluated in relation to occupational ..
  41. PHYTOESTROGENS, ORGANOCHLORINES, AND FIBROID RISK
    Stephen Schwartz; Fiscal Year: 1999
    Phytoestrogens (such as isoflavones and lignans) and organochlorine compounds (such as pesticides and polychlorinated biphenyls) are two broad classes of putative endocnne disruptors -- chemicals that may have the capability to alter a ..
  42. Maternal Pesticide Exposure and Pregnancy Outcomes
    Russ Hauser; Fiscal Year: 2009
    Although the use of polychlorinated biphenyls (PCBs) and many of the chlorinated pesticides, including DDT, are now prohibited or restricted, there remains concern over their potential human health effects because they persist in the ..
  43. Activated Carbon as a Multifunctional Amendment to Treat PCBs and Mercury
    Richard G Luthy; Fiscal Year: 2010
    ..in-situ sediment remediation technique to reduce the bioavailability of both mercury (Hg) and polychlorinated biphenyls (PCBs) at contaminated sediment sites...
  44. Effects of PCBs and PBDEs on Three Distinct Components of Response Inhibition
    Paul A Eubig; Fiscal Year: 2013
    DESCRIPTION (provided by applicant) Although no longer used commercially, polychlorinated biphenyls (PCBs) persist in the environment and exposure is still significant for some human populations...
  45. Serum Organochlorine Levels and Primary Liver Cancer: A Nested Case-Control Study
    Lawrence Engel; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Although polychlorinated biphenyls (PCBs) and certain organochlorine pesticides induce liver tumors in animals, there is limited supporting epidemiologic data because of methodological challenges...
  46. Assessment of Psychostimulant Addiction Risk Following Developmental PCB Exposure
    HELEN J SABLE; Fiscal Year: 2011
    ..Tiie goal of this project is to determine if developmental exposure to polychlorinated biphenyls (RGBs) enhances the predisposition to develop drug addiction using a rodent model...
  47. ORGANOCHLORINE COMPOUNDS AND RISK OF BREAST CANCER
    Tongzhang Zheng; Fiscal Year: 1993
    ..More specifically, this study will test the hypotheses that a) exposure to total polychlorinated biphenyls (PCBs) and specific major PCB congeners increases the risk of female breast cancer; b) exposure to DDT ..
  48. A NOVEL ASSAY FOR MEASUREMENT OF PCB AROCLORS
    Stephen Friedman; Fiscal Year: 2005
    b>Polychlorinated biphenyls (PCBs) are a major public health hazard. We intend to develop the novel Synthetide(tm)-based test array described in Phase I for the measurement of polychlorinated biphenyls (PCBs) in the environment...
  49. NOD-H2H4 MICE AS A SENTINEL MODEL FOR AUTOIMMUNE THYROID
    C Burek; Fiscal Year: 2001
    ..Candidate pollutants include polyaromatic hydrocarbons, polybrominated biphenyls, and polychlorinated biphenyls. Infectious agents are also known to trigger autoimmunity...
  50. MEMBRANE-BASED PRECONCENTRATORS FOR BIOMOLECULES
    James Cox; Fiscal Year: 1991
    ..compounds will include aromatic amines, fatty acids, selected amino acids, polypeptides, phenols and polychlorinated biphenyls. These are of interest to either biological or environmental chemistry...
  51. Organochlorine pesticide, PCBs, and Parkinsons
    Alberto Ascherio; Fiscal Year: 2007
    ..the risk of Parkinson's disease (PD) is predicted by plasma levels of organochlorine pesticides, polychlorinated biphenyls (PCBs), and the antioxidant uric acid...
  52. Aryl hydrocarbon receptor regulation of the cell cycle by chromatin modification
    REBEKA MERSON; Fiscal Year: 2009
    ..g., dioxins, polychlorinated biphenyls) and polycyclic aromatic hydrocarbons (e.g., dimethylbenzanthracene)...
  53. Structure Function Studies on Non-Heme Iron Oxygenases
    Ramaswamy Subramanian; Fiscal Year: 2006
    ..A promising method is bioremediation. Biodegradation of polyaromatic compounds, polychlorinated biphenyls etc. is carried out by several strains of bacteria...
  54. Portable nanofluidic aptamer-SERS instrument for measurement of chemical exposure
    George W Jackson; Fiscal Year: 2012
    ..the specific aims of this research are to develop the aptamer assay for specifically detecting model polychlorinated biphenyls (PCBs), bisphenol-A (BPA), and model phthalates...
  55. CIGARETTE SMOKING OR PCBS EFFECTS ON ESTRADIOL
    Bao Ting Zhu; Fiscal Year: 1999
    ..the profile of multiple estradiol metabolites formed by placentas from women exposed accidentally to polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans which are potent inducers of microsomal monooxygenases...
  56. NEUROBEHAVIORAL CONSEQUENCES OF PRENATAL TCDD EXPOSURE
    Bernard Weiss; Fiscal Year: 2000
    ..prevalent compounds that include the dioxins, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the polychlorinated biphenyls, and some isoflavonoid phytoestrogens...
  57. MOLECULAR & ENVIRONMENTAL FACTORS INFLUENCING MH
    Paul Allen; Fiscal Year: 2003
    ..how pharmacologic agents and exposure to persistent ubiquitous environmental contaminants, such as polychlorinated biphenyls (PCBs), influence the phenotypic penetrance of human MH...
  58. Effects of organochlorines on male infertility
    JULIA WIRTH; Fiscal Year: 2006
    ..studies indicate that environmental contaminants, especially organochlorine compounds (OCs) such as polychlorinated biphenyls (PCBs) and OC pesticides have adverse effects on male reproduction...
  59. Persistent Organochlorines and Testicular Cancer Risk
    Stephen Schwartz; Fiscal Year: 2004
    ..whether the risk of TGCC is related to serum levels of persistent organochlorines, focusing on p,p'-DDE, polychlorinated biphenyls (PCBs), and other compounds (e.g., dieldrin, hexachlorocyclohexanes, hexachlorobenzene)...
  60. PCB Neurotoxicity: Effects on Cerebellar Development
    Lisa Opanashuk; Fiscal Year: 2004
    DESCRIPTION (Taken from the Investigator's Abstract) Polychlorinated biphenyls (PCBS) are widespread and persistent environmental contaminants...
  61. Effects of PCBs on social behavioral development
    HOWARD CROMWELL; Fiscal Year: 2009
    ..objectives are to gain an understanding for the subtle yet potentially devastating effects that polychlorinated biphenyls (PCBs) have on psychologicalfunctions...
  62. DISRUPTION OF ESTROGENIC RESPONSES BY PCB-PAH MIXTURES
    Kathleen Arcaro; Fiscal Year: 2002
    ..Among the chemicals of concern are polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs), which have the potential to disrupt estrogenic ..
  63. PCBs, CYP1A1 Polymorphism and Breast Cancer Risk in CT
    Tongzhang Zheng; Fiscal Year: 2002
    Revised Abstract) DESCRIPTION: Polychlorinated biphenyls (PCBs) are potent environmental endocrine disruptors...
  64. Friends Children's Environmental Health Center
    Susan Schantz; Fiscal Year: 2005
    ..of the FRIENDS Children's Environmental Health Center are to: (1) study the impact of exposure to polychlorinated biphenyls (PCBs) and methylmercury (McHg) on cognitive, sensory and motor development of children, (2) develop ..
  65. FKBP12/RYR MECHANISMS UNDERLYING PCB EFFECTS OF LEARNING
    Isaac Pessah; Fiscal Year: 2000
    Epidemiological studies indicate that developmental exposure to polychlorinated biphenyls (PCBs) represents a significant risk factor affecting parameters of learning and cognition in humans...
  66. Exposure to Organochlorines, EBV, and the Risk of NHL
    Francine Laden; Fiscal Year: 2006
    ..of the disease for organochlorine compounds, such as the pesticide DDT and the industrial chemicals polychlorinated biphenyls (PCBs) and for the Epstein-Barr Virus (EBV)...
  67. Do PCBs alter developing brain structure and cognition?
    Pamela Lein; Fiscal Year: 2003
    There is increasing evidence that perinatal exposure to relatively low levels of polychlorinated biphenyls (PCBs) may cause cognitive and behavioral problems in children...