polychlorinated biphenyls

Summary

Summary: Industrial products consisting of a mixture of chlorinated biphenyl congeners and isomers. These compounds are highly lipophilic and tend to accumulate in fat stores of animals. Many of these compounds are considered toxic and potential environmental pollutants.

Top Publications

  1. ncbi Levels in the U.S. population of those persistent organic pollutants (2003-2004) included in the Stockholm Convention or in other long range transboundary air pollution agreements
    Donald G Patterson
    National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, Mailstop F 17, Atlanta, Georgia 30341, USA
    Environ Sci Technol 43:1211-8. 2009
  2. pmc Low dose of some persistent organic pollutants predicts type 2 diabetes: a nested case-control study
    Duk Hee Lee
    Department of Preventative Medicine, School of Medicine, Kyungpook National University, Daegu, Korea
    Environ Health Perspect 118:1235-42. 2010
  3. pmc Low dose organochlorine pesticides and polychlorinated biphenyls predict obesity, dyslipidemia, and insulin resistance among people free of diabetes
    Duk Hee Lee
    Department of Preventative Medicine, School of Medicine, Kyungpook National University, Daegu, Korea
    PLoS ONE 6:e15977. 2011
  4. pmc Polychlorinated biphenyls and organochlorine pesticides in plasma predict development of type 2 diabetes in the elderly: the prospective investigation of the vasculature in Uppsala Seniors (PIVUS) study
    Duk Hee Lee
    Department of Preventative Medicine, Kyungpook National University, Daegu, Korea
    Diabetes Care 34:1778-84. 2011
  5. pmc Polychlorinated biphenyl-77 induces adipocyte differentiation and proinflammatory adipokines and promotes obesity and atherosclerosis
    Violeta Arsenescu
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA
    Environ Health Perspect 116:761-8. 2008
  6. pmc Increased risk of diabetes and polychlorinated biphenyls and dioxins: a 24-year follow-up study of the Yucheng cohort
    Shu Li Wang
    Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Miaoli, Taiwan
    Diabetes Care 31:1574-9. 2008
  7. pmc Organochlorine exposure and incidence of diabetes in a cohort of Great Lakes sport fish consumers
    Mary Turyk
    Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, Chicago, Illinois 60612, USA
    Environ Health Perspect 117:1076-82. 2009
  8. doi Obesity and persistent organic pollutants: possible obesogenic effect of organochlorine pesticides and polychlorinated biphenyls
    Eveline Dirinck
    Department of Endocrinology, Diabetology and Clinical Pharmacology, Antwerp University Hospital and University of Antwerp, Antwerp, Belgium
    Obesity (Silver Spring) 19:709-14. 2011
  9. ncbi Maternal levels of dichlorodiphenyl-dichloroethylene (DDE) may increase weight and body mass index in adult female offspring
    W Karmaus
    Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, 800 Sumter Street, Columbia, SC 29208 0001, USA
    Occup Environ Med 66:143-9. 2009
  10. pmc Intrinsic human elimination half-lives of polychlorinated biphenyls derived from the temporal evolution of cross-sectional biomonitoring data from the United Kingdom
    Roland Ritter
    Safety and Environmental Technology Group, ETH Zurich, Zurich, Switzerland
    Environ Health Perspect 119:225-31. 2011

Detail Information

Publications372 found, 100 shown here

  1. ncbi Levels in the U.S. population of those persistent organic pollutants (2003-2004) included in the Stockholm Convention or in other long range transboundary air pollution agreements
    Donald G Patterson
    National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, Mailstop F 17, Atlanta, Georgia 30341, USA
    Environ Sci Technol 43:1211-8. 2009
    ..7% of persons aged 12 years and older (90th percentile: 8.3 ng/g lipid, 95% CI: <LOD-13.0 ng/g lipid). Dieldrin was detected in 87.2% of persons aged 12 years and older (95th percentile: 18.9 ng/g lipid, 95% CI: 15.8-24.5 ng/g lipid)...
  2. pmc Low dose of some persistent organic pollutants predicts type 2 diabetes: a nested case-control study
    Duk Hee Lee
    Department of Preventative Medicine, School of Medicine, Kyungpook National University, Daegu, Korea
    Environ Health Perspect 118:1235-42. 2010
    ..Low doses of some persistent organic pollutants (POPs) associate cross-sectionally with type 2 diabetes, whereas associations with high POP exposures are inconsistent...
  3. pmc Low dose organochlorine pesticides and polychlorinated biphenyls predict obesity, dyslipidemia, and insulin resistance among people free of diabetes
    Duk Hee Lee
    Department of Preventative Medicine, School of Medicine, Kyungpook National University, Daegu, Korea
    PLoS ONE 6:e15977. 2011
    ..The current study examined if low dose POPs predicted future adiposity, dyslipidemia, and insulin resistance among controls without diabetes in that study...
  4. pmc Polychlorinated biphenyls and organochlorine pesticides in plasma predict development of type 2 diabetes in the elderly: the prospective investigation of the vasculature in Uppsala Seniors (PIVUS) study
    Duk Hee Lee
    Department of Preventative Medicine, Kyungpook National University, Daegu, Korea
    Diabetes Care 34:1778-84. 2011
    ..However, evidence from prospective studies is sparse. This study was performed to evaluate prospective associations of type 2 diabetes with selected POPs among the elderly...
  5. pmc Polychlorinated biphenyl-77 induces adipocyte differentiation and proinflammatory adipokines and promotes obesity and atherosclerosis
    Violeta Arsenescu
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA
    Environ Health Perspect 116:761-8. 2008
    ..Highly prevalent coplanar polychlorinated biphenyls (PCBs) such as 3,3',4,4'-tetrachlorobiphenyl (PCB-77) accumulate in adipose tissue because of their ..
  6. pmc Increased risk of diabetes and polychlorinated biphenyls and dioxins: a 24-year follow-up study of the Yucheng cohort
    Shu Li Wang
    Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Miaoli, Taiwan
    Diabetes Care 31:1574-9. 2008
    b>Polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs) are important and persistent organic pollutants (POPs) in humans...
  7. pmc Organochlorine exposure and incidence of diabetes in a cohort of Great Lakes sport fish consumers
    Mary Turyk
    Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, Chicago, Illinois 60612, USA
    Environ Health Perspect 117:1076-82. 2009
    ..human exposure to persistent organic pollutants (POPs) such as p,p'-diphenyldichloroethene (DDE) and polychlorinated biphenyls (PCBs)...
  8. doi Obesity and persistent organic pollutants: possible obesogenic effect of organochlorine pesticides and polychlorinated biphenyls
    Eveline Dirinck
    Department of Endocrinology, Diabetology and Clinical Pharmacology, Antwerp University Hospital and University of Antwerp, Antwerp, Belgium
    Obesity (Silver Spring) 19:709-14. 2011
    ..Combined, these results suggest that the diabetogenic effect of low-dose exposure to POPs might be more complicated than a simple obesogenic effect...
  9. ncbi Maternal levels of dichlorodiphenyl-dichloroethylene (DDE) may increase weight and body mass index in adult female offspring
    W Karmaus
    Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, 800 Sumter Street, Columbia, SC 29208 0001, USA
    Occup Environ Med 66:143-9. 2009
    To investigate the effect of prenatal exposure to polychlorinated biphenyls (PCBs) and dichlorodiphenyl-dichloroethylene (DDE) on weight, height and body mass index (BMI) in adult female offspring of the Michigan fisheater cohort ..
  10. pmc Intrinsic human elimination half-lives of polychlorinated biphenyls derived from the temporal evolution of cross-sectional biomonitoring data from the United Kingdom
    Roland Ritter
    Safety and Environmental Technology Group, ETH Zurich, Zurich, Switzerland
    Environ Health Perspect 119:225-31. 2011
    ..However, estimates of intrinsic elimination at background levels are required for risk assessments for the general population...
  11. pmc Serum dioxins and polychlorinated biphenyls are associated with growth among Russian boys
    Jane S Burns
    Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Building I, Room 1404E, Boston, MA 02115, USA
    Pediatrics 127:e59-68. 2011
    We evaluated the associations of serum dioxins and polychlorinated biphenyls (PCBs) with longitudinally assessed growth measurements among peripubertal Russian boys.
  12. pmc Association between type 2 diabetes and exposure to persistent organic pollutants
    Riikka Airaksinen
    Department of Environmental Health, National Institute for Health and Welfare, Kuopio, Finland
    Diabetes Care 34:1972-9. 2011
    ..The purpose of this cross-sectional study is to examine the association between type 2 diabetes and POP exposure in the Helsinki Birth Cohort Study...
  13. pmc Partition of environmental chemicals between maternal and fetal blood and tissues
    Larry L Needham
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Sci Technol 45:1121-6. 2011
    ..Although the environmental chemicals examined pass through the placenta and are excreted into milk, partitions between maternal and fetal samples are not uniform...
  14. pmc Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity
    Isaac N Pessah
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Pharmacol Ther 125:260-85. 2010
    ....
  15. ncbi A strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes: results from the National Health and Examination Survey 1999-2002
    Duk Hee Lee
    Department of Preventive Medicine, School of Medicine, Kyungpook University, 101 Dongin dong, Jung Gu, Daegu, Korea 700 422
    Diabetes Care 29:1638-44. 2006
    ..Low-level exposure to some persistent organic pollutants (POPs) has recently become a focus because of their possible link with the risk of diabetes...
  16. pmc Prenatal exposure to organohalogens, including brominated flame retardants, influences motor, cognitive, and behavioral performance at school age
    Elise Roze
    Division of Neonatology, Beatrix Children s Hospital, University Medical Center Groningen, The Netherlands
    Environ Health Perspect 117:1953-8. 2009
    ..Organohalogen compounds (OHCs) are known to have neurotoxic effects on the developing brain...
  17. pmc Fate and complex pathogenic effects of dioxins and polychlorinated biphenyls in obese subjects before and after drastic weight loss
    Min Ji Kim
    INSERM, UMR S, Universite Paris Descartes, Centre Universitaire des Saints Peres, France
    Environ Health Perspect 119:377-83. 2011
    ..In humans, persistent organic pollutants (POPs) are stored primarily in adipose tissue. Their total body burden and their contribution to obesity-associated diseases remain unclear...
  18. pmc Serum concentrations of polychlorinated biphenyls in relation to in vitro fertilization outcomes
    John D Meeker
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, USA
    Environ Health Perspect 119:1010-6. 2011
    Human exposure to polychlorinated biphenyls (PCBs) remains widespread...
  19. ncbi Plasma polychlorobiphenyl and organochlorine pesticide level and risk of major lymphoma subtypes
    P Cocco
    Department of Public Health, Occupational Health Section, Asse Didattico Policlinico Universitario, SS 554, Km 4, 500, 09042 Monserrato Cagliari, Italy
    Occup Environ Med 65:132-40. 2008
    ..There is conflicting epidemiological evidence concerning an increase in risk of non-Hodgkin's lymphoma (NHL) associated with elevated blood levels of persistent organochlorine (OC) pesticides and polychlorobiphenyls (PCBs)...
  20. ncbi Developmental aspects of environmental neurotoxicology: lessons from lead and polychlorinated biphenyls
    Gerhard Winneke
    Division of Neurobehavioral Toxicology, Medical Institute of Environmental Hygiene, Heinrich Heine Universitat, Auf m Hennekamp 50, D 40225, Dusseldorf, Germany
    J Neurol Sci 308:9-15. 2011
    ..However, for only few of these, namely inorganic lead, arsenic, organic mercury and polychlorinated biphenyls (PCBs), human evidence is available to suggest that these may cause neurodevelopmental adversity and may,..
  21. pmc Prevalence of metabolic syndrome associated with body burden levels of dioxin and related compounds among Japan's general population
    Hirokazu Uemura
    Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Environ Health Perspect 117:568-73. 2009
    ..Environmental exposure to some persistent organic pollutants has been reported to be associated with a metabolic syndrome in the U.S. population...
  22. ncbi Perinatal exposure to polychlorinated biphenyls differentially affects cerebellar development and motor functions in male and female rat neonates
    K Nguon
    Department of Psychiatry, Brigham and Women s Hospital, Boston, MA, USA
    Cerebellum 4:112-22. 2005
    Perinatal exposure to polychlorinated biphenyls (PCBs) interacts with genetics and impacts the course of the central nervous system (CNS) development in both humans and animals...
  23. pmc Relationship of thyroid hormone levels to levels of polychlorinated biphenyls, lead, p,p'- DDE, and other toxicants in Akwesasne Mohawk youth
    Lawrence M Schell
    Department of Anthropology, University at Albany, State University of New York, Albany, New York 12222, USA
    Environ Health Perspect 116:806-13. 2008
    It is well documented that acute exposure to high levels of persistent organic pollutants, such as polychlorinated biphenyls (PCBs), p,p'-dichlorophenyldichloroethylene (p,p'-DDE), and hexachlorobenzene (HCB), can affect human health ..
  24. ncbi ortho-substituted PCB95 alters intracellular calcium signaling and causes cellular acidification in PC12 cells by an immunophilin-dependent mechanism
    P W Wong
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis 95616, USA
    J Neurochem 76:450-63. 2001
    ....
  25. pmc Exposure to p,p'-DDE: a risk factor for type 2 diabetes
    Anna Rignell-Hydbom
    Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, University Hospital, Lund, Sweden
    PLoS ONE 4:e7503. 2009
    ..Reversed causality can however not be excluded. The aim of this case-control study was to evaluate whether POPs concentration is a risk factor for type 2 diabetes...
  26. pmc Polychlorinated biphenyls disrupt intestinal integrity via NADPH oxidase-induced alterations of tight junction protein expression
    Yean Jung Choi
    Department of Neurosurgery, University of Kentucky, Lexington, 40536, USA
    Environ Health Perspect 118:976-81. 2010
    b>Polychlorinated biphenyls (PCBs) are widely distributed environmental toxicants that contribute to numerous disease states...
  27. pmc Apparent half-lives of dioxins, furans, and polychlorinated biphenyls as a function of age, body fat, smoking status, and breast-feeding
    Meghan O Grady Milbrath
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109 2029, USA
    Environ Health Perspect 117:417-25. 2009
    ....
  28. pmc Non-dioxin-like polychlorinated biphenyls and risk of endometriosis
    Britton Trabert
    University of Washington, Seattle, Washington, USA
    Environ Health Perspect 118:1280-5. 2010
    ..Environmental contaminants, including polychlorinated biphenyls (PCBs), are hypothesized to contribute to endometriosis risk through effects on steroid hormones.
  29. pmc Polychlorinated biphenyl (PCB) exposure and diabetes: results from the Anniston Community Health Survey
    Allen E Silverstone
    State University of New York Upstate Medical University, Syracuse, New York 13210, USA
    Environ Health Perspect 120:727-32. 2012
    b>Polychlorinated biphenyls (PCBs) manufactured in Anniston, Alabama, from 1929 to 1971 caused significant environmental contamination. The Anniston population remains one of the most highly exposed in the world.
  30. pmc Plasma organochlorine levels and risk of non-Hodgkin lymphoma in the Nurses' Health Study
    Francine Laden
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 19:1381-4. 2010
    Numerous studies have reported positive associations of environmental exposure to polychlorinated biphenyls (PCB) and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) with the risk of non-Hodgkin lymphoma (NHL)...
  31. doi Correcting serum concentrations of organochlorine compounds by lipids: alternatives to the organochlorine/total lipids ratio
    Miquel Porta
    Institut Municipal d Investigació Mèdica Hospital del Mar, E 08003 Barcelona, Catalonia, Spain
    Environ Int 35:1080-5. 2009
    ..Our aim was to analyze the relationship between serum OC and TL in patients with pancreatic ductal adenocarcinoma (PDA), and to explore several alternatives to perform the OC lipid correction...
  32. ncbi Relationships between polychlorinated biphenyls and health status in harbor porpoises (Phocoena phocoena) stranded in the United Kingdom
    Paul D Jepson
    Institute of Zoology, Zoological Society of London, Regent s Park, London NW1 4RY, United Kingdom
    Environ Toxicol Chem 24:238-48. 2005
    ....
  33. pmc Organochlorines in Swedish women: determinants of serum concentrations
    Anders Wicklund Glynn
    Swedish National Food Administration, Uppsala, Sweden
    Environ Health Perspect 111:349-55. 2003
    ..This shows that the studied organochlorines should not be treated as a homogeneous group of compounds in epidemiologic studies...
  34. pmc Perinatal exposure to polychlorinated biphenyls alters social behaviors in rats
    Banafsheh Jolous-Jamshidi
    Department of Biological Sciences, Bowling Green State University, Bowling Green, OH 43403 0208, USA
    Toxicol Lett 199:136-43. 2010
    Perinatal exposure to polychlorinated biphenyls (PCBs) leads to significant alterations of neural and hormonal systems. These alterations have been shown to impair motor and sensory development...
  35. doi Maternal exposure to high levels of dioxins in relation to birth weight in women affected by Yusho disease
    Kiyomi Tsukimori
    Department of Obstetrics, Fukuoka Children s Hospital, Japan
    Environ Int 38:79-86. 2012
    ..exposure to polychlorinated dibenzo-p-dioxin (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) with decreased birth weight in humans have produced conflicting results...
  36. ncbi Prenatal pesticide and PCB exposures and birth outcomes
    Mary S Wolff
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Pediatr Res 61:243-50. 2007
    Evidence is inconsistent or poorly understood for links between polychlorinated biphenyls (PCBs), 1,1'-dichloro-2,2'-bis(4-chlorophenyl)ethylene (DDE), and organophosphate (OP) pesticides and adverse pregnancy outcomes, although they are ..
  37. pmc Birth weight and prenatal exposure to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE): a meta-analysis within 12 European Birth Cohorts
    Eva Govarts
    Environmental Risk and Health, Flemish Institute for Technological Research VITO, Mol, Belgium
    Environ Health Perspect 120:162-70. 2012
    ..prenatal eXposure to the development of obesity later in life) projects, we examined the hypothesis that the combination of polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE) adversely affects birth weight.
  38. pmc Polychlorinated biphenyl exposure and neuropsychological status among older residents of upper Hudson River communities
    Edward F Fitzgerald
    Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, State University of New York, One University Place, Rensselaer, NY 12144, USA
    Environ Health Perspect 116:209-15. 2008
    b>Polychlorinated biphenyls (PCBs) may accelerate the cognitive and motor dysfunction found in normal aging, but few studies have examined these outcomes and PCB exposure among older adults.
  39. pmc Assaying organochlorines in archived serum for a large, long-term cohort: implications of combining assay results from multiple laboratories over time
    Robert I Sholtz
    Child Health and Development Studies, Public Health Institute, Berkeley, CA 94709, USA
    Environ Int 37:709-14. 2011
    ..We sought to determine whether we could successfully combine assay results for DDT-related compounds and polychlorinated biphenyls (PCBs) in serum from the same birth cohort obtained from different laboratories over time...
  40. doi Prenatal exposures to persistent and non-persistent organic compounds and effects on immune system development
    Irva Hertz-Picciotto
    Center for Children s Environmental Health and Department of Public Health Sciences, University of California, Davis, CA 95616, USA
    Basic Clin Pharmacol Toxicol 102:146-54. 2008
    ....
  41. ncbi Environmental exposure to dioxins and polychlorinated biphenyls reduce levels of gonadal hormones in newborns: results from the Duisburg cohort study
    Yuguang Cao
    Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Int J Hyg Environ Health 211:30-9. 2008
    ..axis (HPG) is being discussed as underlying developmental adversity of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs). This study was done to evaluate effects related to the HPG axis.
  42. doi Serum levels of polychlorinated biphenyls in Mexican women and breast cancer risk
    Rogelio Recio-Vega
    Centro de Investigacion Biomedica, Facultad de Medicina, Unidad Torreón, Universidad Autonoma de Coahuila, Mexico
    J Appl Toxicol 31:270-8. 2011
    ..This study was designed to evaluate the relation between polychlorinated biphenyls (PCB) exposure and breast cancer risk in Mexican women. We recruited 140 women from the General Hospital...
  43. doi Associations of polychlorinated biphenyl exposure and endogenous hormones with diabetes in post-menopausal women previously employed at a capacitor manufacturing plant
    Victoria Persky
    University of Illinois School of Public Health, 1603 West Taylor St, Chicago, IL 60612, USA
    Environ Res 111:817-24. 2011
    ..This analysis examines relationships of serum polychlorinated biphenyls (PCBs), work exposure and endogenous hormones with self-reported history of diabetes after control for ..
  44. ncbi Polychlorinated biphenyls and thyroid hormone serum concentrations among people living in a highly polluted area: a cross-sectional population-based study
    Francesco Donato
    Department of Experimental and Applied Medicine, Institute of Hygiene, Epidemiology and Public Health, University of Brescia, Viale Europa 11, Brescia, Italy
    Environ Res 108:380-6. 2008
    b>Polychlorinated biphenyls (PCBs) may interact with several thyroid functions. Severe environmental pollution by PCBs has been observed in Brescia, Italy, due to the presence of a factory that produced these compounds until 1984.
  45. ncbi A food chain model to predict the levels of lipophilic organic contaminants in humans
    Gertje Czub
    Baltic Sea Research Institute, Rostock, Germany
    Environ Toxicol Chem 23:2356-66. 2004
    ..This suggests that ACC-HUMAN is a useful tool for predicting human exposure to bioaccumulative organic compounds. It can be linked easily to existing multimedia fate and transport models...
  46. ncbi Calculation of serum "total lipid" concentrations for the adjustment of persistent organohalogen toxicant measurements in human samples
    John T Bernert
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE Atlanta, Georgia 30341, United States
    Chemosphere 68:824-31. 2007
    Persistent organohalogen toxicants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin or polychlorinated biphenyls measured in human serum are often expressed on a lipid weight basis, most commonly by dividing the toxicants' concentration by ..
  47. pmc Predictors of serum dioxins and PCBs among peripubertal Russian boys
    Jane S Burns
    Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 117:1593-9. 2009
    Although sources and routes of exposure to dioxins and polychlorinated biphenyls (PCBs) have been studied, information regarding exposure among children is limited...
  48. ncbi Strategies for bioremediation of polychlorinated biphenyls
    Yoshiyuki Ohtsubo
    Department of Environmental Life Sciences, Graduate School of Life Sciences, Tohoku University, 2 1 1 Katahira, Sendai, 980 8577, Japan
    Appl Microbiol Biotechnol 65:250-8. 2004
    b>Polychlorinated biphenyls (PCBs) are serious environmental pollutants that threaten both the natural ecosystem and human health...
  49. pmc The effect of lipid adjustment on the analysis of environmental contaminants and the outcome of human health risks
    Audrey J Gaskins
    Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Schriver National Institute of Child Health and Human Development, NIH, Rockville, MD, USA
    Methods Mol Biol 580:371-81. 2009
    ..four statistical models (unadjusted, standardized, adjusted, and two-stage) for the analysis of polychlorinated biphenyls (PCBs) exposure, serum lipids, and health outcome risk...
  50. ncbi Serum hormones in boys prenatally exposed to polychlorinated biphenyls and dibenzofurans
    Ping Chi Hsu
    Department of Safety, Health and Environmental Engineering, National Kaohsiung First University of Science and Technology, Kaohsiung, Taiwan
    J Toxicol Environ Health A 68:1447-56. 2005
    b>Polychlorinated biphenyls (PCBs) and dibenzofurans (PCDFs) are persistent environmental pollutants shown to adversely interact with several functions of the endocrine system...
  51. ncbi The use of a non-lethal tool for evaluating toxicological hazard of organochlorine contaminants in Mediterranean cetaceans: new data 10 years after the first paper published in MPB
    M Cristina Fossi
    Department of Environmental Sciences, Siena University, Via delle Cerchia 3, Via Mattioli 4, 53100 Siena, Italy
    Mar Pollut Bull 46:972-82. 2003
    ..delphis. These results suggest that BPMO induction may be an early sign of exposure to organochlorine EDCs and can be used for periodic monitoring of Mediterranean marine mammal toxicological status...
  52. doi POP levels in breast milk and maternal serum and thyroid hormone levels in mother-child pairs from Uppsala, Sweden
    P O Darnerud
    National Food Administration, PO Box 622, 751 26 Uppsala, Sweden
    Environ Int 36:180-7. 2010
    ..When comparing studies that investigate associations between TH levels and POP levels during the perinatal stage, no obvious between-study concordance was seen regarding the critical dose for hormonal effects to occur...
  53. ncbi Gene expression profiling in rat cerebellum following in utero and lactational exposure to mixtures of methylmercury, polychlorinated biphenyls and organochlorine pesticides
    B K Padhi
    Environment and Occupational Toxicology Division, HECSB, Health Canada, Tunney s Pasture, Ottawa, Ontario K1A 0L2, Canada
    Toxicol Lett 176:93-103. 2008
    ..of Canadian arctic populations, to components of the NCM administered separately (methylmercury (MeHg), polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCs)) or to the goitrogen propylthiouracyl...
  54. doi Endocrine disruptors and thyroid hormone physiology
    Mary Line Jugan
    Univ Paris Sud 11, Faculte de Pharmacie, Laboratoire Santé Publique Environnement, 92290 Chatenay Malabry, France
    Biochem Pharmacol 79:939-47. 2010
    ..Here, we survey the main thyroid-disrupting chemicals, such as polychlorinated biphenyls, perchlorates, and brominated flame-retardants, that are characteristic disruptors of thyroid hormone ..
  55. ncbi Concentrations of polychlorinated biphenyls in indoor air and polybrominated diphenyl ethers in indoor air and dust in Birmingham, United Kingdom: implications for human exposure
    Stuart Harrad
    Division of Environmental Health and Risk Management, Public Health Building, School of Geography, Earth, and Environmental Sciences, University of Birmingham, Birmingham, B15 2TT, United Kingdom
    Environ Sci Technol 40:4633-8. 2006
    Polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) were measured in air (using PUF disk passive samplers) in 31 homes, 33 offices, 25 cars, and 3 public microenvironments...
  56. pmc Evidence of an age-related threshold effect of polychlorinated biphenyls (PCBs) on neuropsychological functioning in a Native American population
    Richard F Haase
    Division of Counseling Psychology, Department of Educational and Counseling Psychology, University at Albany, State University of New York, ED 220, 1400 Washington Avenue, Albany, NY 12222, USA
    Environ Res 109:73-85. 2009
    b>Polychlorinated biphenyls (PCBs) have been suspected for some time of having adverse effects on neuropsychological functioning in humans...
  57. doi Mechanisms involved in the neurotoxic effects of environmental toxicants such as polychlorinated biphenyls and brominated flame retardants
    Frode Fonnum
    Department of Biochemistry, Institute for Basal Medicine, University of Oslo, Oslo, Norway
    J Neurochem 111:1327-47. 2009
    ..Approximately 1.2 million metric tons of polychlorinated biphenyls (PCBs) have been produced and about 30% have been discharged to the environment...
  58. doi Blood pressure and hypertension in relation to levels of serum polychlorinated biphenyls in residents of Anniston, Alabama
    Alexey Goncharov
    Department of Environmental Health Sciences, School of Public Health, University at Albany, Rensselaer, New York 12144, USA
    J Hypertens 28:2053-60. 2010
    To determine risk factors for elevated blood pressure and hypertension in residents of Anniston, Alabama who live near a plant that manufactured polychlorinated biphenyls (PCBs).
  59. ncbi Association of polychlorinated biphenyls with hypertension in the 1999-2002 National Health and Nutrition Examination Survey
    Charles J Everett
    Department of Family Medicine, Medical University of South Carolina, 295 Calhoun Street, MSC 192, Charleston, SC 9425 1920, USA
    Environ Res 108:94-7. 2008
    The association of 11 polychlorinated biphenyls (PCBs) with hypertension was investigated using the National Health and Nutrition Examination Survey (NHANES), 1999-2002...
  60. ncbi Neurobehavioural functions in adult progeny of rat mothers exposed to methylmercury or 2,2', 4,4', 5,5'-hexachlorobiphenyl (PCB 153) alone or their combination during gestation and lactation
    Sławomir Gralewicz
    Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, Łódź, Poland
    Int J Occup Med Environ Health 22:277-91. 2009
    Methylmercury (MeHg) and polychlorinated biphenyls (PCBs) are ubiquitous environmental pollutants. Both are neurotoxic, especially for the developing brain. The main source of human exposure to MeHg and PCBs is seafood...
  61. pmc An exploratory study of diabetes in a First Nation community with respect to serum concentrations of p,p'-DDE and PCBs and fish consumption
    Aline Philibert
    CINBIOSE, Universite du Quebec a Montreal UQAM, Montreal, Quebec, Canada
    Int J Environ Res Public Health 6:3179-89. 2009
    ..These findings support the hypothesis that environmental exposure to elevated p,p'-DDE and PCBs is associated with increased risk of diabetes. Consumption of trout and white fish may be beneficial to reduce risk...
  62. ncbi Carcinogenicity of "non-dioxinlike" polychlorinated biphenyls
    Stefanie Knerr
    Food Chemistry and Environmental Toxicology, University of Kaiserslautern, Kaiserslautern, Germany
    Crit Rev Toxicol 36:663-94. 2006
    Complex technical mixtures of polychlorinated biphenyls (PCBs) cause liver and thyroid neoplasms in rodents, whereas very few data are available on the carcinogenic potency of single non-dioxinlike (NDL) PCB congeners...
  63. pmc Plasma organochlorine levels and risk of non-Hodgkin lymphoma in a cohort of men
    Kimberly A Bertrand
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Epidemiology 21:172-80. 2010
    Environmental exposure to polychlorinated biphenyls (PCBs) and p,p'-dichlorodiphenyldichloroethylene (p, p'-DDE) has been associated with the risk of non-Hodgkin lymphoma.
  64. pmc Prenatal organochlorine exposure and behaviors associated with attention deficit hyperactivity disorder in school-aged children
    Sharon K Sagiv
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 171:593-601. 2010
    ..76, 95% confidence interval: 1.06, 2.92) and a similar relation for p,p'-DDE. These results support an association between low-level prenatal organochlorine exposure and ADHD-like behaviors in childhood...
  65. pmc Perfluorinated compounds, polychlorinated biphenyls, and organochlorine pesticide contamination in composite food samples from Dallas, Texas, USA
    Arnold Schecter
    Division of Environmental and Occupational Health Sciences, University of Texas School of Public Health, Dallas, Texas 75390, USA
    Environ Health Perspect 118:796-802. 2010
    ..S. food by measuring perfluorinated compounds (PFCs), organochlorine pesticides, and polychlorinated biphenyls (PCBs) in composite food samples...
  66. ncbi Persistent organic pollutants and the burden of diabetes
    Miquel Porta
    Institut Municipal d Investigacio Medica, Universitat Autonoma de Barcelona, E 08003 Barcelona, Spain
    Lancet 368:558-9. 2006
  67. ncbi Effect of polychlorinated biphenyls (PCBs) and 1,1,1-trichloro-2,2,-bis (4-chlorophenyl)-ethane (DDT) in follicular fluid on the results of in vitro fertilization-embryo transfer (IVF-ET) programs
    Simona Jirsová
    Department of Gynecology and Obstetrics, Charles University, First Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic
    Fertil Steril 93:1831-6. 2010
    ..To establish the effect of chlorinated organic compounds on fertility...
  68. pmc Serum concentrations of antibodies against vaccine toxoids in children exposed perinatally to immunotoxicants
    Carsten Heilmann
    Paediatric Clinic II, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Environ Health Perspect 118:1434-8. 2010
    b>Polychlorinated biphenyls (PCBs) may cause immunotoxic effects, but the detailed dose-response relationship and possible vulnerable time windows of exposure are uncertain...
  69. pmc Mechanistic basis of resistance to PCBs in Atlantic tomcod from the Hudson River
    Isaac Wirgin
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    Science 331:1322-5. 2011
    ..of vertebrate populations to contaminants, including Atlantic tomcod from the Hudson River (HR) to polychlorinated biphenyls (PCBs), is unknown...
  70. pmc Environmental organochlorine exposure as a potential etiologic factor in breast cancer
    M S Wolff
    Department of Community Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Environ Health Perspect 103:141-5. 1995
    ....
  71. doi Environmental chemicals and thyroid function: an update
    Malene Boas
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Curr Opin Endocrinol Diabetes Obes 16:385-91. 2009
    ..To overview the effects of endocrine disrupters on thyroid function...
  72. doi Relationship of polychlorinated biphenyls with type 2 diabetes and hypertension
    Charles Jay Everett
    Department of Family Medicine, Medical University of South Carolina, 295 Calhoun Street, MSC 192, Charleston, SC 29425 1920, USA
    J Environ Monit 13:241-51. 2011
    ..and environmental factors which may include exposure to persistent organic pollutants (POPs) such as polychlorinated biphenyls (PCBs)...
  73. ncbi Developmental neurotoxicity of PCBs in humans: what do we know and where do we go from here?
    S L Schantz
    Institute for Environmental Studies, University of Illinois at Urbana Champaign 61801, USA
    Neurotoxicol Teratol 18:217-27; discussion 229-76. 1996
    ..Hopefully, several new studies that are currently underway will help to resolve the uncertainties regarding the risks of perinatal PCB exposure that have been created by the conflicting results of these early studies...
  74. ncbi The Duisburg birth cohort study: influence of the prenatal exposure to PCDD/Fs and dioxin-like PCBs on thyroid hormone status in newborns and neurodevelopment of infants until the age of 24 months
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Universitatsstr 150, 44801 Bochum, Germany
    Mutat Res 659:83-92. 2008
    Prenatal exposure to polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) can affect neurobehavioral development of infants and children...
  75. pmc Lead and PCBs as risk factors for attention deficit/hyperactivity disorder
    Paul A Eubig
    Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois at Urbana Champaign, Urbana, Illinois 61802, USA
    Environ Health Perspect 118:1654-67. 2010
    ..In this review we present evidence that environmental chemicals, particularly polychlorinated biphenyls (PCBs) and lead, are associated with deficits in many neurobehavioral functions that are also impaired ..
  76. ncbi Organochlorines and risk of non-Hodgkin lymphoma
    John J Spinelli
    BC Cancer Agency, Vancouver, British Columbia, Canada
    Int J Cancer 121:2767-75. 2007
    Organochlorine chemicals and polychlorinated biphenyls (PCBs) have been suspected as possible risk factors for non-Hodgkin lymphoma (NHL)...
  77. ncbi Persistent organochlorine chemicals in plasma and risk of non-Hodgkin's lymphoma
    Anneclaire J De Roos
    Fred Hutchinson Cancer Research Center and University of Washington Department of Epidemiology, Seattle, Washington 98109 1024, USA
    Cancer Res 65:11214-26. 2005
    b>Polychlorinated biphenyls (PCB) have been suspected as possible contributors to increasing non-Hodgkin's lymphoma incidence during the latter half of the 20th century based on their toxicologic properties and provocative epidemiologic ..
  78. pmc PCB-containing wood floor finish is a likely source of elevated PCBs in residents' blood, household air and dust: a case study of exposure
    Ruthann A Rudel
    Silent Spring Institute, 29 Crafts Street, Newton, MA 02458, USA
    Environ Health 7:2. 2008
    b>Polychlorinated biphenyls (PCBs) are persistent pollutants identified worldwide as human blood and breast milk contaminants. Because they bioaccumulate, consumption of meat, fish, and dairy products predicts human blood concentrations...
  79. pmc Polychlorinated biphenyls 105 and 118 form thyroid hormone receptor agonists after cytochrome P4501A1 activation in rat pituitary GH3 cells
    Kelly J Gauger
    Molecular and Cellular Biology Program, University of Massachusetts Amherst, Massachusetts 01003, USA
    Environ Health Perspect 115:1623-30. 2007
    b>Polychlorinated biphenyls (PCBs) may interfere with thyroid hormone (TH) signaling by reducing TH levels in blood, by exerting direct effects on TH receptors (TRs), or both.
  80. doi The relation of environmental contaminants exposure to behavioral indicators in Inuit preschoolers in Arctic Quebec
    P Plusquellec
    CHUQ Research Center, Quebec, QC, Canada
    Neurotoxicology 31:17-25. 2010
    ..behavioral development, less is known regarding the relation between child behavior and exposure to polychlorinated biphenyls (PCBs) and mercury (Hg)...
  81. ncbi Polychlorinated biphenyl levels in peripheral blood and non-Hodgkin's lymphoma: a report from three cohorts
    Lawrence S Engel
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 67:5545-52. 2007
    ..Limited evidence suggests that increased concentrations of polychlorinated biphenyls (PCB) measured in blood or fat tissue are associated with increased risk of NHL...
  82. pmc Immunologic biomarkers in relation to exposure markers of PCBs and dioxins in Flemish adolescents (Belgium)
    Rosette L Van Den Heuvel
    Department of Toxicology, Vito Flemish Institute of Technological Research, Mol, Belgium
    Environ Health Perspect 110:595-600. 2002
    ..changes in humoral or cellular immunity or respiratory complaints were related to blood serum levels of polychlorinated biphenyls (PCBs) and dioxin-like compounds after lifetime exposure in Flanders (Belgium)...
  83. ncbi Towards a global historical emission inventory for selected PCB congeners--a mass balance approach 3. An update
    Knut Breivik
    Norwegian Institute for Air Research, P O Box 100, NO 2027 Kjeller, Norway
    Sci Total Environ 377:296-307. 2007
    ..The national emission data for each of the 114 countries considered is spatially resolved on a 1 degrees x1 degrees grid for each congener and year, using population density as a surrogate...
  84. ncbi Cognitive development in preschool children prenatally exposed to PCBs and MeHg
    Paul W Stewart
    Department of Psychology, State University of New York at Oswego, Oswego, NY 13126, USA
    Neurotoxicol Teratol 25:11-22. 2003
    A number of epidemiological studies have shown predictive relationships between prenatal exposure to polychlorinated biphenyls (PCBs) and subtle deficits in cognitive development in infancy through the preschool years [Child Dev...
  85. pmc Polychlorinated biphenyls, organochlorine pesticides and neurodevelopment
    Susan A Korrick
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Pediatr 20:198-204. 2008
    Although environmental levels of polychlorinated biphenyls and certain organochlorine pesticides--hexachlorobenzene, dichlorodiphenyl trichloroethane and its primary metabolite, dichlorodiphenyl dichloroethene--are generally on the ..
  86. ncbi Estrogens and environmental estrogens
    H Tapiero
    Laboratoire de Pharmacologie Cellulaire and Moléculaire, CNRS UMR 8612, Universite de Paris Sud, Faculte de Pharmacie, Chatenay Malabry, France
    Biomed Pharmacother 56:36-44. 2002
    ..DES), synthetic environmental estrogens such as beta-hexachlorocyclohexane (beta-HCH), polychlorinated biphenyls (PCBs), o, p, p'DDT, 4-nonylphenol (NP) and phytoestrogens such as isoflavones or lignans, are more ..
  87. pmc The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds
    Martin van den Berg
    World Health Organization Collaborating Centre for Research on Environmental Health Risk Assessment and Institute for Risk Assessment Sciences, Science and University Medical Center, Universiteit Utrecht, The Netherlands
    Toxicol Sci 93:223-41. 2006
    ..in Geneva during which the toxic equivalency factors (TEFs) for dioxin-like compounds, including some polychlorinated biphenyls (PCBs), were reevaluated...
  88. doi Low-dose persistent organic pollutants increased telomere length in peripheral leukocytes of healthy Koreans
    Ji Yeon Shin
    Department of Preventive Medicine, School of Medicine, Kyungpook National University, 101 Dongin dong, Jung Gu, Daegu, 700 422 Korea
    Mutagenesis 25:511-6. 2010
    ..Among various POPs, serum concentrations of organochlorine (OC) pesticides, polychlorinated biphenyls (PCBs) and polybrominated diphenylethers were measured...
  89. doi Towards an understanding of the link between environmental emissions and human body burdens of PCBs using CoZMoMAN
    Knut Breivik
    Norwegian Institute for Air Research, P O Box 100, NO 2027 Kjeller, Norway
    Environ Int 36:85-91. 2010
    ..and mechanistic understanding of the link between environmental emissions and human body burdens for polychlorinated biphenyls (PCBs) in the western part of the Baltic Sea drainage basin and to identify any remaining knowledge gaps...
  90. ncbi Brain monoaminergic neurotransmission parameters in weanling rats after perinatal exposure to methylmercury and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153)
    Anna F Castoldi
    IRCCS Maugeri Foundation, Toxicology Division, Research Centre, Via Palestro 26, 27100 Pavia, Italy
    Brain Res 1112:91-8. 2006
    ..The combined treatment with MeHg and PCB153 does not exacerbate the neurochemical effects of the individual compounds...
  91. doi Prototype of a porous ZnO SPV-based sensor for PCB detection at room temperature under visible light illumination
    Mingtao Li
    Key Laboratory of Materials Physics, Institute of Solid State Physics, Chinese Academy of Sciences, Hefei 230031, People s Republic of China
    Langmuir 26:13703-6. 2010
    To detect polychlorinated biphenyls (PCBs), a prototype of a porous ZnO sensor based on the surface photovoltage (SPV) mechanism working under visible light illumination at room temperature has been presented...
  92. ncbi Mortality factors, helminth burden, and contaminant residues in white-tailed sea eagles (Haliaeetus albicilla) from Finland
    Oliver Krone
    Institute for Zoo and Wildlife Research, Berlin, Germany
    Ambio 35:98-104. 2006
    ..All organ levels of chlorinated pesticides, polychlorinated biphenyls, and cadmium were moderate and not harmful for birds of prey...
  93. doi Circulating levels of persistent organic pollutants associate in divergent ways to fat mass measured by DXA in humans
    Monika Rönn
    Occupational and Environmental Medicine, Department of Medicine, Uppsala University, and Department of Medicine, Uppsala University Hospital, Uppsala, Sweden
    Chemosphere 85:335-43. 2011
    ..Environmental contaminants have recently been implicated in the pathogenesis of obesity...
  94. ncbi Prenatal exposure to methylmercury and PCBs affects distinct stages of information processing: an event-related potential study with Inuit children
    Olivier Boucher
    Ecole de Psychologie, Universite Laval, Quebec, Canada
    Neurotoxicology 31:373-84. 2010
    Methylmercury (MeHg) and polychlorinated biphenyls (PCBs) are seafood contaminants known for their adverse effects on neurodevelopment...
  95. ncbi Effects of perinatal exposure to PCBs on neuropsychological functions in the Rotterdam cohort at 9 years of age
    Hestien J I Vreugdenhil
    Department of Pediatrics, Division of Neonatology, Erasmus MC Sophia, Rotterdam, Netherlands
    Neuropsychology 18:185-93. 2004
    ..A longer breast-feeding duration was associated with lower TOL scores and with better spatial organizational skills. There was some evidence of negative effects of lactational exposure to PCBs on scores on the TOL...
  96. pmc Population physiologically based pharmacokinetic modeling for the human lactational transfer of PCB-153 with consideration of worldwide human biomonitoring results
    Laurel E Redding
    Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Zhunan, Miaoli, Taiwan
    Environ Health Perspect 116:1629-35. 2008
    One of the most serious human health concerns related to environmental contamination with polychlorinated biphenyls (PCBs) is the presence of these chemicals in breast milk.
  97. pmc Investigating intergenerational differences in human PCB exposure due to variable emissions and reproductive behaviors
    Cristina L Quinn
    Department of Chemistry, University of Toronto Scarborough, Scarborough, Ontario, Canada
    Environ Health Perspect 119:641-6. 2011
    ..as age of childbearing, parity, and breast-feeding prevalence--have changed over the same historical time period as emissions of polychlorinated biphenyls (PCB) and may produce intergenerational differences in human PCB exposure.
  98. pmc Polychlorinated biphenyls, lead, and mercury are associated with liver disease in American adults: NHANES 2003-2004
    Matt Cave
    Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Louisville, Louisville, Kentucky 40202, USA
    Environ Health Perspect 118:1735-42. 2010
    ..However, the potential role of low-level environmental pollution on liver disease in the general population has not been evaluated...
  99. ncbi PCDDs/PCDFs and dioxin-like PCBs: recent body burden levels and their determinants among general inhabitants in Japan
    Hirokazu Uemura
    Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15, Kuramoto Cho, Tokushima 770 8503, Japan
    Chemosphere 73:30-7. 2008
    ..recent body burden levels of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (DL-PCBs) and to investigate their determinants among general inhabitants in Japan.
  100. pmc In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes
    Christine P Curran
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0056, USA
    Toxicol Sci 119:189-208. 2011
    b>Polychlorinated biphenyls (PCBs) are persistent toxic pollutants occurring as complex mixtures in the environment...
  101. ncbi PCBs and HCHs in a salt-marsh sediment record from South-Central Chile: use of tsunami signatures and 137Cs fallout as temporal markers
    Ricardo Barra
    Aquatic Systems Research Unit, EULA Chile Center, Environmental Sciences Center, University of Concepcion, Barrio Universitario s n, P O Box 160 C, Concepcion, Chile
    Chemosphere 55:965-72. 2004
    ..6 ng/cm2/year, reflecting that PCBs are still in use and being released into the environment...

Research Grants86

  1. Health Effects of Lifetime Exposure to Food Contaminants
    Philippe Grandjean; Fiscal Year: 2006
    ..Postnatal exposure to MeHg and to polychlorinated biphenyls and related contaminants will be assessed by detailed questionnaire and by analysis of appropriate ..
  2. Metal and Organochlorines Exposure: Impact on Adolescent Behavior and Cognition
    Susan Korrick; Fiscal Year: 2007
    ..3) In addition, we will assess the role of prenatal exposure to prevalent organochlorines - polychlorinated biphenyls (PCBs), dichlorodiphenyl dichloroethene (DDE), and hexachlorobenzene (HCB) -- as effect modifiers of ..
  3. Polybrominated Biphenyls and Cancer Risk
    KARIN ROSENBLATT; Fiscal Year: 2007
    ..and other environmentally persistent organohalogens such as polybrominated diphenyl ether (PBDEs), polychlorinated biphenyls (PCBs), and organochlorine pesticides (such as DDT and DDE) have also been thought to have this property...
  4. Health Effects of Lifetime Exposure to Food Contaminants
    Philippe Grandjean; Fiscal Year: 2009
    ..Postnatal exposure to MeHg and to polychlorinated biphenyls and related contaminants will be assessed by detailed questionnaire and by analysis of appropriate ..
  5. Metal and Organochlorines Exposure: Impact on Adolescent Behavior and Cognition
    Susan A Korrick; Fiscal Year: 2010
    ..3) In addition, we will assess the role of prenatal exposure to prevalent organochlorines - polychlorinated biphenyls (PCBs), dichlorodiphenyl dichloroethene (DDE), and hexachlorobenzene (HCB) -- as effect modifiers of ..
  6. Childhood Leukemia and Home Environmental Exposures
    Patricia A Buffler; Fiscal Year: 2010
    ..suspected carcinogens in house dust and indoor air, including pesticides, persistent organic compounds (polychlorinated biphenyls, polycyclic aromatic hydrocarbons, and nicotine, a surrogate for tobacco smoke), and volatile organic ..
  7. Novel Zebrafish Models to Study Toxicity of PCBs and Pesticides During Pregnancy
    Lisa Satterwhite; Fiscal Year: 2009
    ..in children in the Baltimore-Washington area that correlated with accidental release of dioxins and polychlorinated biphenyls (PCBs)...
  8. Novel Zebrafish Models to Study Toxicity of PCBs and Pesticides During Pregnancy
    Lisa Satterwhite; Fiscal Year: 2007
    ..in children in the Baltimore-Washington area that correlated with accidental release of dioxins and polychlorinated biphenyls (PCBs)...
  9. Nutrition and Superfund Chemical Toxicity
    Bernhard Hennig; Fiscal Year: 2009
    ..The investigators will concentrate on chlorinated organics (e.g., polychlorinated biphenyls) prevalent in most Superfund sites, including those found in Kentucky...
  10. Nutrition and Superfund Chemical Toxicity
    Bernhard Hennig; Fiscal Year: 2009
    ..The investigators will concentrate on chlorinated organics (e.g., polychlorinated biphenyls) prevalent in most Superfund sites, including those found in Kentucky...
  11. Nutrition and Superfund Chemical Toxicity
    Bernhard Hennig; Fiscal Year: 2009
    ..The investigators will concentrate on chlorinated organics (e.g., polychlorinated biphenyls) prevalent in most Superfund sites, including those found in Kentucky...
  12. Measuring Human Exposure to PBDEs
    Thomas F Webster; Fiscal Year: 2010
    ..Structurally similar to polychlorinated biphenyls (PCBs), several PBDE congeners perturb hormonal signaling and are toxic to the nervous and reproductive ..
  13. SUPERFUND TOXIC SUBSTANCES--EXPOSURE AND DISEASE
    Richard Monson; Fiscal Year: 2001
    ..Reproductive health is being evaluated in relation to environmental exposure to lead, mercury, polychlorinated biphenyls (PCBs) and related compounds; cardio-respiratory health is being evaluated in relation to occupational ..
  14. SUPERFUND TOXIC SUBSTANCES--EXPOSURE AND DISEASE
    Richard Monson; Fiscal Year: 2003
    ..Reproductive health is being evaluated in relation to environmental exposure to lead, mercury, polychlorinated biphenyls (PCBs) and related compounds; cardio-respiratory health is being evaluated in relation to occupational ..
  15. SUPERFUND TOXIC SUBSTANCES--EXPOSURE AND DISEASE
    Richard Monson; Fiscal Year: 2000
    ..Reproductive health is being evaluated in relation to environmental exposure to lead, mercury, polychlorinated biphenyls (PCBs) and related compounds; cardio-respiratory health is being evaluated in relation to occupational ..
  16. SUPERFUND TOXIC SUBSTANCES--EXPOSURE AND DISEASE
    Richard Monson; Fiscal Year: 2002
    ..Reproductive health is being evaluated in relation to environmental exposure to lead, mercury, polychlorinated biphenyls (PCBs) and related compounds; cardio-respiratory health is being evaluated in relation to occupational ..
  17. SUPERFUND TOXIC SUBSTANCES--EXPOSURE AND DISEASE
    Karl Kelsey; Fiscal Year: 2006
    ..Reproductive health is being evaluated in relation to environmental exposure to lead, mercury, polychlorinated biphenyls (PCBs) and related compounds; cardio-respiratory health is being evaluated in relation to occupational ..
  18. SUPERFUND TOXIC SUBSTANCES--EXPOSURE AND DISEASE
    Karl Kelsey; Fiscal Year: 2004
    ..Reproductive health is being evaluated in relation to environmental exposure to lead, mercury, polychlorinated biphenyls (PCBs) and related compounds; cardio-respiratory health is being evaluated in relation to occupational ..
  19. Measuring Human Exposure to PBDEs
    Thomas Webster; Fiscal Year: 2009
    ..Structurally similar to polychlorinated biphenyls (PCBs), several PBDE congeners perturb hormonal signaling and are toxic to the nervous and reproductive ..
  20. SUPERFUND TOXIC SUBSTANCES--EXPOSURE AND DISEASE
    Karl Kelsey; Fiscal Year: 2005
    ..Reproductive health is being evaluated in relation to environmental exposure to lead, mercury, polychlorinated biphenyls (PCBs) and related compounds; cardio-respiratory health is being evaluated in relation to occupational ..
  21. Measuring Human Exposure to PBDEs
    Thomas Webster; Fiscal Year: 2009
    ..Structurally similar to polychlorinated biphenyls (PCBs), several PBDE congeners perturb hormonal signaling and are toxic to the nervous and reproductive ..
  22. Childhood Leukemia and Home Environmental Exposures
    Patricia Buffler; Fiscal Year: 2009
    ..suspected carcinogens in house dust and indoor air, including pesticides, persistent organic compounds (polychlorinated biphenyls, polycyclic aromatic hydrocarbons, and nicotine, a surrogate for tobacco smoke), and volatile organic ..
  23. AhR and reproductive aging
    BRIAN PETROFF; Fiscal Year: 2007
    ..Hundreds of manmade compounds including dioxins, polychlorinated biphenyls and carcinogens in cigarette smoke act on cells through the aryl hydrocarbon receptor (AhR) pathway...
  24. Neuropsychological & Thyroid Effects of Perfluorinated Compounds in Older Adults
    Edward Fitzgerald; Fiscal Year: 2009
    ..It builds upon an ongoing study of polychlorinated biphenyls (PCBs), polybrominated biphenylethers (PBDEs), and dioxin-like compounds (DLCs) by adding PFCs to the ..
  25. PHYTOESTROGENS, ORGANOCHLORINES, AND FIBROID RISK
    Stephen Schwartz; Fiscal Year: 1999
    Phytoestrogens (such as isoflavones and lignans) and organochlorine compounds (such as pesticides and polychlorinated biphenyls) are two broad classes of putative endocnne disruptors -- chemicals that may have the capability to alter a ..
  26. Health Effects of Lifetime Exposure to Food Contaminants
    Philippe Grandjean; Fiscal Year: 2007
    ..Postnatal exposure to MeHg and to polychlorinated biphenyls and related contaminants will be assessed by detailed questionnaire and by analysis of appropriate ..
  27. Maternal Pesticide Exposure and Pregnancy Outcomes
    Russ Hauser; Fiscal Year: 2009
    Although the use of polychlorinated biphenyls (PCBs) and many of the chlorinated pesticides, including DDT, are now prohibited or restricted, there remains concern over their potential human health effects because they persist in the ..
  28. Maternal Pesticide Exposure and Pregnancy Outcomes
    Russ Hauser; Fiscal Year: 2006
    Although the use of polychlorinated biphenyls (PCBs) and many of the chlorinated pesticides, including DDT, are now prohibited or restricted, there remains concern over their potential human health effects because they persist in the ..
  29. Maternal Pesticide Exposure and Pregnancy Outcomes
    Russ Hauser; Fiscal Year: 2007
    Although the use of polychlorinated biphenyls (PCBs) and many of the chlorinated pesticides, including DDT, are now prohibited or restricted, there remains concern over their potential human health effects because they persist in the ..
  30. PROCEDURES TO ASSESS THE HAZARD OF A SUPERFUND SITE
    Stephen Safe; Fiscal Year: 1992
    ..The HAHs include the polychlorinated biphenyls (PCBs), polychlorinated naphthalenes (PCNs), polychlorinated benzenes, polychlorinated phenols, ..
  31. MULTIDISCIPLINARY STUDY OF PCBS & PCDFS AT A WASTE SITE
    David Carpenter; Fiscal Year: 1990
    This proposal is directed at the human health hazards from exposure to polychlorinated biphenyls (PCBs) and their virulently toxic impurities, polychlorinated dibenzofurans (PCDFs)...
  32. Serum Organochlorine Levels and Primary Liver Cancer: A Nested Case-Control Study
    Lawrence Engel; Fiscal Year: 2007
    Although polychlorinated biphenyls (PCBs) and certain organochlorine pesticides induce liver tumors in animals, there is limited supporting epidemiologic data because of methodological challenges...
  33. Serum Organochlorine Levels and Primary Liver Cancer: A Nested Case-Control Study
    Lawrence Engel; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Although polychlorinated biphenyls (PCBs) and certain organochlorine pesticides induce liver tumors in animals, there is limited supporting epidemiologic data because of methodological challenges...
  34. ORGANOCHLORINE COMPOUNDS AND RISK OF BREAST CANCER
    Tongzhang Zheng; Fiscal Year: 1993
    ..More specifically, this study will test the hypotheses that a) exposure to total polychlorinated biphenyls (PCBs) and specific major PCB congeners increases the risk of female breast cancer; b) exposure to DDT ..
  35. A NOVEL ASSAY FOR MEASUREMENT OF PCB AROCLORS
    Stephen Friedman; Fiscal Year: 2004
    b>Polychlorinated biphenyls (PCBs) are a major public health hazard. We intend to develop the novel Synthetide(tm)-based test array described in Phase I for the measurement of polychlorinated biphenyls (PCBs) in the environment...
  36. A NOVEL ASSAY FOR MEASUREMENT OF PCB AROCLORS
    Stephen Friedman; Fiscal Year: 2005
    b>Polychlorinated biphenyls (PCBs) are a major public health hazard. We intend to develop the novel Synthetide(tm)-based test array described in Phase I for the measurement of polychlorinated biphenyls (PCBs) in the environment...
  37. A NOVEL ASSAY FOR MEASUREMENT OF PCB AROCLORS
    Stephen Friedman; Fiscal Year: 2005
    b>Polychlorinated biphenyls (PCBs) are a major public health hazard. We intend to develop the novel Synthetide(tm)-based test array described in Phase I for the measurement of polychlorinated biphenyls (PCBs) in the environment...
  38. Exposure levels of persistent pollutants in urban anglers
    Anne Golden; Fiscal Year: 2001
    ..The complex mix of chemicals found in these waters includes polychlorinated biphenyls (PCBs), mercury, and the organochlorine pesticides chlordane and DDT...
  39. Diabetes and Persistent Organic Pollutants
    MARY ELLEN TURYK; Fiscal Year: 2010
    ..Persistent organic pollutants (POPs) such as dioxins, polychlorinated biphenyls (PCBs), p,p'-diphenyldichloroethene (DDE), and polybrominated biphenyl ethers (PBDEs) are ..
  40. Diabetes and Persistent Organic Pollutants
    Mary Turyk; Fiscal Year: 2009
    ..Persistent organic pollutants (POPs) such as dioxins, polychlorinated biphenyls (PCBs), p,p'-diphenyldichloroethene (DDE), and polybrominated biphenyl ethers (PBDEs) are ..
  41. REGULATION OF CYTOCHROME P450-B/E IN HEPATOCYTE CULTURE
    Erin Schuetz; Fiscal Year: 1993
    ..PB) and phenobarbital-like agents, including organochlorine pesticides (Kepone and o,p-DDT) and certain polychlorinated biphenyls (PCBs) in rat liver...
  42. CHILDHOOD DIOXIN EXPOSURE AND ENERGY HOMEOSTASIS DYSREGULATION
    Jane S Burns; Fiscal Year: 2010
    ..concentrations of polychlorinated dibenzo- p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and polychlorinated biphenyls (PCBs) with elevated serum glucose and insulin, and greater risk of type 2 diabetes mellitus (T2DM)...
  43. CHILDHOOD DIOXIN EXPOSURE AND ENERGY HOMEOSTASIS DYSREGULATION
    Jane Burns; Fiscal Year: 2009
    ..concentrations of polychlorinated dibenzo- p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and polychlorinated biphenyls (PCBs) with elevated serum glucose and insulin, and greater risk of type 2 diabetes mellitus (T2DM)...
  44. NOD-H2H4 MICE AS A SENTINEL MODEL FOR AUTOIMMUNE THYROID
    C Burek; Fiscal Year: 2001
    ..Candidate pollutants include polyaromatic hydrocarbons, polybrominated biphenyls, and polychlorinated biphenyls. Infectious agents are also known to trigger autoimmunity...
  45. NOD-H2H4 MICE AS A SENTINEL MODEL FOR AUTOIMMUNE THYROID
    C Burek; Fiscal Year: 2000
    ..Candidate pollutants include polyaromatic hydrocarbons, polybrominated biphenyls, and polychlorinated biphenyls. Infectious agents are also known to trigger autoimmunity...
  46. NOD H2H4 MICE AS A SENTINEL MODEL FOR AUTOIMMUNE THYROID
    C Burek; Fiscal Year: 1999
    ..Candidate pollutants include polyaromatic hydrocarbons, polybrominated biphenyls, and polychlorinated biphenyls. Infectious agents are also known to trigger autoimmunity...
  47. MOLECULAR BASIS OF SELECTIVE P450 2B FUNCTION
    James R Halpert; Fiscal Year: 2010
    ..of the mechanism by which drugs such as phenobarbital and environmental contaminants such as polychlorinated biphenyls activate gene expression...
  48. MOLECULAR BASIS OF SELECTIVE P450 2B FUNCTION
    JAMES HALPERT; Fiscal Year: 2009
    ..of the mechanism by which drugs such as phenobarbital and environmental contaminants such as polychlorinated biphenyls activate gene expression...
  49. The role of heterocyclic aromatic amines in breast cancer
    Robert J Turesky; Fiscal Year: 2010
    ..to find a direct connection between exposure to environmental and dietary pollutants such as pesticides, polychlorinated biphenyls or polycyclic aromatic hydrocarbons and breast cancer...
  50. The role of heterocyclic aromatic amines in breast cancer
    ROBERT TURESKY; Fiscal Year: 2009
    ..to find a direct connection between exposure to environmental and dietary pollutants such as pesticides, polychlorinated biphenyls or polycyclic aromatic hydrocarbons and breast cancer...
  51. Metal and Organochlorines Exposure: Impact on Adolescent Behavior and Cognition
    Susan Korrick; Fiscal Year: 2006
    ..3) In addition, we will assess the role of prenatal exposure to prevalent organochlorines - polychlorinated biphenyls (PCBs), dichlorodiphenyl dichloroethene (DDE), and hexachlorobenzene (HCB) -- as effect modifiers of ..
  52. Metal and Organochlorines Exposure: Impact on Adolescent Behavior and Cognition
    Susan Korrick; Fiscal Year: 2009
    ..3) In addition, we will assess the role of prenatal exposure to prevalent organochlorines - polychlorinated biphenyls (PCBs), dichlorodiphenyl dichloroethene (DDE), and hexachlorobenzene (HCB) -- as effect modifiers of ..
  53. Metal and Organochlorines Exposure: Impact on Adolescent Behavior and Cognition
    Susan Korrick; Fiscal Year: 2009
    ..3) In addition, we will assess the role of prenatal exposure to prevalent organochlorines - polychlorinated biphenyls (PCBs), dichlorodiphenyl dichloroethene (DDE), and hexachlorobenzene (HCB) -- as effect modifiers of ..
  54. Organochlorine pesticide, PCBs, and Parkinsons
    Alberto Ascherio; Fiscal Year: 2006
    ..the risk of Parkinson's disease (PD) is predicted by plasma levels of organochlorine pesticides, polychlorinated biphenyls (PCBs), and the antioxidant uric acid...
  55. Organochlorine pesticide, PCBs, and Parkinsons
    Alberto Ascherio; Fiscal Year: 2005
    ..whether the risk of Parkinson's disease (PD) is predicted by plasma levels of organochlorine pesticides, polychlorinated biphenyls (PCBs), and the antioxidant uric acid...
  56. Organochlorine pesticide, PCBs, and Parkinsons
    Alberto Ascherio; Fiscal Year: 2007
    ..the risk of Parkinson's disease (PD) is predicted by plasma levels of organochlorine pesticides, polychlorinated biphenyls (PCBs), and the antioxidant uric acid...
  57. MEMBRANE-BASED PRECONCENTRATORS FOR BIOMOLECULES
    James Cox; Fiscal Year: 1991
    ..compounds will include aromatic amines, fatty acids, selected amino acids, polypeptides, phenols and polychlorinated biphenyls. These are of interest to either biological or environmental chemistry...
  58. Aryl hydrocarbon receptor regulation of the cell cycle by chromatin modification
    REBEKA MERSON; Fiscal Year: 2009
    ..g., dioxins, polychlorinated biphenyls) and polycyclic aromatic hydrocarbons (e.g., dimethylbenzanthracene)...
  59. Aryl hydrocarbon receptor regulation of the cell cycle by chromatin modification
    REBEKA MERSON; Fiscal Year: 2007
    ..g., dioxins, polychlorinated biphenyls) and polycyclic aromatic hydrocarbons (e.g., dimethylbenzanthracene)...
  60. Dioxins and Male Pubertal Growth and Development
    Russ Hauser; Fiscal Year: 2006
    ..of concern are a family of compounds that includes polychlorinated dibenzo-p-dioxins, dibenzofurans and polychlorinated biphenyls. These compounds are reproductive and developmental toxins in laboratory animals and in limited human ..
  61. CONSEQUENCES OF AhR-MEDIATED SIGNALING IN DENDRITIC CELLS
    David Shepherd; Fiscal Year: 2002
    ..Many of these chemicals that include the dioxins, furans, and polychlorinated biphenyls (PCBs) persist for very long periods of time in the environment and have the potential to affect ..
  62. Dioxins and Male Pubertal Growth and Development
    Russ Hauser; Fiscal Year: 2007
    ..of concern are a family of compounds that includes polychlorinated dibenzo-p-dioxins, dibenzofurans and polychlorinated biphenyls. These compounds are reproductive and developmental toxins in laboratory animals and in limited human ..
  63. Dioxins and Male Pubertal Growth and Development
    Russ Hauser; Fiscal Year: 2009
    ..of concern are a family of compounds that includes polychlorinated dibenzo-p-dioxins, dibenzofurans and polychlorinated biphenyls. These compounds are reproductive and developmental toxins in laboratory animals and in limited human ..
  64. PLACENTAL/UTERINE EFFECTS OF CHLORINATED HYDROCARBONS
    Kathleen Shiverick; Fiscal Year: 1999
    ..mechanisms by which the chlorinated hydrocarbons 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polychlorinated biphenyls (PCBs) have disruptive effects on placental- uterine function...
  65. PLACENTAL/UTERINE EFFECTS OF CHLORINATED HYDROCARBONS
    Kathleen Shiverick; Fiscal Year: 1999
    ..mechanisms by which the chlorinated hydrocarbons 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polychlorinated biphenyls (PCBs) have disruptive effects on placental- uterine function...
  66. Environmental influences of Ah receptor ligands on gene expression
    Robert Tukey; Fiscal Year: 2000
    ..chemicals such as polycyclic aromatic hydrocarbons (PAHs), halogenated aromatic hydrocarbons (HAHs) and polychlorinated biphenyls (PCBs) are known human health toxicants. Their toxicity is associated with altered gene expression...
  67. Early Disease Biomarkers of PCB-exposed Human Population
    Sisir K Dutta; Fiscal Year: 2010
    Current studies suggest that several human diseases involve gene-environment interaction. Polychlorinated biphenyls (PCBs) are neurodevelopmental and immunological toxicants in experimental animals treated prenatally...
  68. Structure Function Studies on Non-Heme Iron Oxygenases
    Ramaswamy Subramanian; Fiscal Year: 2002
    ..A promising method is bioremediation. Biodegradation of polyaromatic compounds, polychlorinated biphenyls etc. is carried out by several strains of bacteria...
  69. Structure Function Studies on Non-Heme Iron Oxygenases
    Ramaswamy Subramanian; Fiscal Year: 2003
    ..A promising method is bioremediation. Biodegradation of polyaromatic compounds, polychlorinated biphenyls etc. is carried out by several strains of bacteria...
  70. Early Disease Biomarkers of PCB-exposed Human Population
    Sisir K Dutta; Fiscal Year: 2010
    Current studies suggest that several human diseases involve gene-environment interaction. Polychlorinated biphenyls (PCBs) are neurodevelopmental and immunological toxicants in experimental animals treated prenatally...
  71. Structure Function Studies on Non-Heme Iron Oxygenases
    Ramaswamy Subramanian; Fiscal Year: 2005
    ..A promising method is bioremediation. Biodegradation of polyaromatic compounds, polychlorinated biphenyls etc. is carried out by several strains of bacteria...
  72. Early Disease Biomarkers of PCB-exposed Human Population
    Sisir Dutta; Fiscal Year: 2009
    Current studies suggest that several human diseases involve gene-environment interaction. Polychlorinated biphenyls (PCBs) are neurodevelopmental and immunological toxicants in experimental animals treated prenatally...
  73. Structure Function Studies on Non-Heme Iron Oxygenases
    Ramaswamy Subramanian; Fiscal Year: 2006
    ..A promising method is bioremediation. Biodegradation of polyaromatic compounds, polychlorinated biphenyls etc. is carried out by several strains of bacteria...
  74. Structure Function Studies on Non-Heme Iron Oxygenases
    Ramaswamy Subramanian; Fiscal Year: 2003
    ..A promising method is bioremediation. Biodegradation of polyaromatic compounds, polychlorinated biphenyls etc. is carried out by several strains of bacteria...
  75. Structure Function Studies on Non-Heme Iron Oxygenases
    Ramaswamy Subramanian; Fiscal Year: 2004
    ..A promising method is bioremediation. Biodegradation of polyaromatic compounds, polychlorinated biphenyls etc. is carried out by several strains of bacteria...
  76. Early Disease Biomarkers of PCB-exposed Human Population
    Sisir Dutta; Fiscal Year: 2007
    Current studies suggest that several human diseases involve gene-environment interaction. Polychlorinated biphenyls (PCBs) are neurodevelopmental and immunological toxicants in experimental animals treated prenatally...
  77. PCB DISRUPTION OF THYROID HORMONE
    Robert Zoeller; Fiscal Year: 2000
    ..Investigator's Abstract) The long-term goals of this research are to determine the mechanisms by which polychlorinated biphenyls (PCBs) disrupt thyroid hormone action during brain development, and to define the neurological ..
  78. PCB DISRUPTION OF THYROID HORMONE
    Robert Zoeller; Fiscal Year: 2001
    ..Investigator's Abstract) The long-term goals of this research are to determine the mechanisms by which polychlorinated biphenyls (PCBs) disrupt thyroid hormone action during brain development, and to define the neurological ..
  79. PCB DISRUPTION OF THYROID HORMONE
    Robert Zoeller; Fiscal Year: 2003
    ..Investigator's Abstract) The long-term goals of this research are to determine the mechanisms by which polychlorinated biphenyls (PCBs) disrupt thyroid hormone action during brain development, and to define the neurological ..
  80. ELECTROCATALYTIC STUDIES OF TOXIC POLLUTANT ACTIVATION
    James Rusling; Fiscal Year: 1999
    ..Organohalide pollutants such as chlorodioxins and polychlorinated biphenyls are not as easily activated, but they elevate cytochrome P450 levels in the body, promoting the chance ..
  81. ELECTROCATALYTIC STUDIES OF TOXIC POLLUTANT ACTIVATION
    James Rusling; Fiscal Year: 2001
    ..Organohalide pollutants such as chlorodioxins and polychlorinated biphenyls are not as easily activated, but they elevate cytochrome P450 levels in the body, promoting the chance ..
  82. Intervention to Reduce Body Burden of PCBs in Residents of Anniston Alabama
    Ronald J Jandacek; Fiscal Year: 2010
    ..will test the use of a safe and minimally invasive dietary intervention to enhance the removal of toxic polychlorinated biphenyls (PCBs) from individuals with elevated levels of these compounds...