ddt

Summary

Summary: A polychlorinated pesticide that is resistant to destruction by light and oxidation. Its unusual stability has resulted in difficulties in residue removal from water, soil, and foodstuffs. This substance may reasonably be anticipated to be a carcinogen: Fourth Annual Report on Carcinogens (NTP-85-002, 1985). (From Merck Index, 11th ed)

Top Publications

  1. pmc The Anopheles gambiae detoxification chip: a highly specific microarray to study metabolic-based insecticide resistance in malaria vectors
    Jean Philippe David
    Vector Research Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L35QA, United Kingdom
    Proc Natl Acad Sci U S A 102:4080-4. 2005
  2. ncbi A single p450 allele associated with insecticide resistance in Drosophila
    P J Daborn
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Science 297:2253-6. 2002
  3. pmc Identification and validation of a gene causing cross-resistance between insecticide classes in Anopheles gambiae from Ghana
    Sara N Mitchell
    Vector Group, Liverpool School of Tropical Medicine, Liverpool L35QA, United Kingdom
    Proc Natl Acad Sci U S A 109:6147-52. 2012
  4. doi Insecticide resistance and its association with target-site mutations in natural populations of Anopheles gambiae from eastern Uganda
    Urvashi Ramphul
    Vector Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Trans R Soc Trop Med Hyg 103:1121-6. 2009
  5. doi Distribution of pyrethroid and DDT resistance and the L1014F kdr mutation in Anopheles gambiae s.l. from Burkina Faso (West Africa)
    K R Dabire
    Insitut de Recherche en Science de la Santé IRSS Centre Muraz, BP 390, Bobo Dioulasso, Burkina Faso
    Trans R Soc Trop Med Hyg 103:1113-20. 2009
  6. doi Does kdr genotype predict insecticide-resistance phenotype in mosquitoes?
    Martin J Donnelly
    Vector Group, Liverpool School of Tropical Medicine, Liverpool L35QA, UK
    Trends Parasitol 25:213-9. 2009
  7. pmc Comparison of house spraying and insecticide-treated nets for malaria control
    C F Curtis
    London School of Hygiene and Tropical Medicine, London WC1E 7HT, England
    Bull World Health Organ 78:1389-400. 2000
  8. doi A significant increase in kdr in Anopheles gambiae is associated with an intensive vector control intervention in Burundi highlands
    Natacha Protopopoff
    Department of Parasitology, Prince Leopold Institute of Tropical Medicine, Antwerp, Belgium
    Trop Med Int Health 13:1479-87. 2008
  9. pmc Global status of DDT and its alternatives for use in vector control to prevent disease
    Henk van den Berg
    Laboratory of Entomology, Wageningen University, Wageningen, The Netherlands
    Environ Health Perspect 117:1656-63. 2009
  10. pmc A new classification system for the actions of IRS chemicals traditionally used for malaria control
    John P Grieco
    Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
    PLoS ONE 2:e716. 2007

Detail Information

Publications334 found, 100 shown here

  1. pmc The Anopheles gambiae detoxification chip: a highly specific microarray to study metabolic-based insecticide resistance in malaria vectors
    Jean Philippe David
    Vector Research Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L35QA, United Kingdom
    Proc Natl Acad Sci U S A 102:4080-4. 2005
    ..The applications of this detox chip and its potential contribution to malaria vector insecticide resistance management programs are discussed...
  2. ncbi A single p450 allele associated with insecticide resistance in Drosophila
    P J Daborn
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Science 297:2253-6. 2002
    ..Here, via microarray analysis of all P450s in Drosophila melanogaster, we show that DDT-R, a gene conferring resistance to DDT, is associated with overtranscription of a single cytochrome P450 gene, ..
  3. pmc Identification and validation of a gene causing cross-resistance between insecticide classes in Anopheles gambiae from Ghana
    Sara N Mitchell
    Vector Group, Liverpool School of Tropical Medicine, Liverpool L35QA, United Kingdom
    Proc Natl Acad Sci U S A 109:6147-52. 2012
    ..The gene-expression profile of a highly DDT-resistant population of A. gambiae s.s. from Ghana was characterized using a unique whole-genome microarray...
  4. doi Insecticide resistance and its association with target-site mutations in natural populations of Anopheles gambiae from eastern Uganda
    Urvashi Ramphul
    Vector Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Trans R Soc Trop Med Hyg 103:1121-6. 2009
    ..larvae sampled from two ecologically distinct breeding sites and exposed to WHO discriminating concentrations of DDT, permethrin, deltamethrin, bendiocarb and malathion. Survival rates to DDT were as high as 85...
  5. doi Distribution of pyrethroid and DDT resistance and the L1014F kdr mutation in Anopheles gambiae s.l. from Burkina Faso (West Africa)
    K R Dabire
    Insitut de Recherche en Science de la Santé IRSS Centre Muraz, BP 390, Bobo Dioulasso, Burkina Faso
    Trans R Soc Trop Med Hyg 103:1113-20. 2009
    This study reports on the distribution of pyrethroid and DDT resistance and the L1014F knockdown resistance (kdr) mutation in Anopheles gambiae s.l...
  6. doi Does kdr genotype predict insecticide-resistance phenotype in mosquitoes?
    Martin J Donnelly
    Vector Group, Liverpool School of Tropical Medicine, Liverpool L35QA, UK
    Trends Parasitol 25:213-9. 2009
    ..We assert that the link between kdr genotype and DDT- and pyrethroid-susceptibility phenotype is clear...
  7. pmc Comparison of house spraying and insecticide-treated nets for malaria control
    C F Curtis
    London School of Hygiene and Tropical Medicine, London WC1E 7HT, England
    Bull World Health Organ 78:1389-400. 2000
    ..pyrethroid-treated nets were at least as efficacious as house spraying with dichlorodiphenyltrichloroethane (DDT), malathion or a pyrethroid...
  8. doi A significant increase in kdr in Anopheles gambiae is associated with an intensive vector control intervention in Burundi highlands
    Natacha Protopopoff
    Department of Parasitology, Prince Leopold Institute of Tropical Medicine, Antwerp, Belgium
    Trop Med Int Health 13:1479-87. 2008
    ..l.) was determined for six consecutive years within the framework of a vector control programme. Findings were also linked with the insecticide resistance status observed with bioassay in An. gambiae s.l. and An. funestus...
  9. pmc Global status of DDT and its alternatives for use in vector control to prevent disease
    Henk van den Berg
    Laboratory of Entomology, Wageningen University, Wageningen, The Netherlands
    Environ Health Perspect 117:1656-63. 2009
    I review the status of dichlorodiphenyltrichloroethane (DDT), used for disease vector control, along with current evidence on its benefits and risks in relation to the available alternatives.
  10. pmc A new classification system for the actions of IRS chemicals traditionally used for malaria control
    John P Grieco
    Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
    PLoS ONE 2:e716. 2007
    ..The laboratory tests showed the primary action of DDT is repellent, alphacypermethrin is irritant, and dieldrin is only toxic...
  11. pmc The Pine River statement: human health consequences of DDT use
    Brenda Eskenazi
    School of Public Health, University of California Berkeley, 2150 Shattuck Avenue, Berkeley, CA 94720, USA
    Environ Health Perspect 117:1359-67. 2009
    Dichlorodiphenyltrichloroethane (DDT) was used worldwide until the 1970s, when concerns about its toxic effects, its environmental persistence, and its concentration in the food supply led to use restrictions and prohibitions...
  12. ncbi Anopheles arabiensis and An. quadriannulatus resistance to DDT in South Africa
    K Hargreaves
    Malaria Control Programme, KwaZulu Natal Department of Health, Jozini, South Africa
    Med Vet Entomol 17:417-22. 2003
    ..Western-type houses there are currently sprayed with deltamethrin, whereas traditional houses are sprayed with DDT for malaria control...
  13. doi Knockdown resistance to DDT and pyrethroids: from target-site mutations to molecular modelling
    Tg Emyr Davies
    Biological Chemistry Department, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK
    Pest Manag Sci 64:1126-30. 2008
    Naturally derived insecticides such as pyrethrum and man-made insecticides such as DDT and the synthetic pyrethroids act on the voltage-gated sodium channel proteins found in insect nerve-cell membranes...
  14. pmc Comparative molecular modeling of Anopheles gambiae CYP6Z1, a mosquito P450 capable of metabolizing DDT
    Ting Lan Chiu
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 105:8855-60. 2008
    ..the years developed resistance to insecticides including dieldrin, 1,1-bis(p-chlorophenyl)-2,2,2-trichloroethane (DDT), and pyrethroids. Previous microarray studies using fragments of 230 An...
  15. doi Differential resistance of insect sodium channels with kdr mutations to deltamethrin, permethrin and DDT
    Mark J Burton
    School of Biology, University of Nottingham, University Park, Nottingham NG72RD, UK
    Insect Biochem Mol Biol 41:723-32. 2011
    ..Treatment of the wild-type channel with deltamethrin (≥ 1 nM), permethrin (≥ 30 nM) or DDT (≥ 1 μM) resulted in hyperpolarizing shifts in V(50,act)...
  16. pmc Trends in DDT and pyrethroid resistance in Anopheles gambiae s.s. populations from urban and agro-industrial settings in southern Cameroon
    Philippe Nwane
    Organisation de Coordination pour la Lutte Contre les Endemies en Afrique Centrale, Yaounde, Cameroun
    BMC Infect Dis 9:163. 2009
    ..This study highlights trends in DDT and pyrethroid resistance in wild An. gambiae populations from South Cameroon.
  17. pmc Identification of a novel class of insect glutathione S-transferases involved in resistance to DDT in the malaria vector Anopheles gambiae
    H Ranson
    School of Biosciences, Main College, Cardiff University, PO Box 915, Cardiff CF10 3TL, Wales, UK
    Biochem J 359:295-304. 2001
    ..gambiae map to a region of the genome on chromosome 3R that contains a major DDT [1,1,1-trichloro-2,2-bis-(p-chlorophenyl)ethane] resistance gene, suggesting that this gene family is involved in ..
  18. ncbi DDT, pyrethrins, pyrethroids and insect sodium channels
    T G E Davies
    Biological Chemistry Division, Rothamsted Research, Hertfordshire, UK
    IUBMB Life 59:151-62. 2007
    ..b>DDT, the pyrethrins and the synthetic pyrethroids (the latter currently accounting for around 17% of the world ..
  19. pmc Distribution of knock-down resistance mutations in Anopheles gambiae molecular forms in west and west-central Africa
    Federica Santolamazza
    Istituto Pasteur Fondazione Cenci Bolognetti, Universita La Sapienza, Rome, Italy
    Malar J 7:74. 2008
    Knock-down resistance (kdr) to DDT and pyrethroids in the major Afrotropical vector species, Anopheles gambiae sensu stricto, is associated with two alternative point mutations at amino acid position 1014 of the voltage-gated sodium ..
  20. ncbi Elevated activity of an Epsilon class glutathione transferase confers DDT resistance in the dengue vector, Aedes aegypti
    Nongkran Lumjuan
    Vector Research Group, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK
    Insect Biochem Mol Biol 35:861-71. 2005
    ..In the mosquito, Anopheles gambiae, increased expression of an Epsilon class GST, GSTE2, confers resistance to DDT. We have identified eight GST genes in the dengue vector, Aedes aegypti...
  21. pmc Spatio-temporal patterns in kdr frequency in permethrin and DDT resistant Anopheles gambiae s.s. from Uganda
    Katrijn Verhaeghen
    Department of Parasitology, Prince Leopold Institute of Tropical Medicine, Nationalestraat 155, B 2000 Antwerpen, Belgium
    Am J Trop Med Hyg 82:566-73. 2010
    ..Therefore, the pyrethroid and DDT resistance status of Anopheles gambiae s.l...
  22. pmc Control of pyrethroid and DDT-resistant Anopheles gambiae by application of indoor residual spraying or mosquito nets treated with a long-lasting organophosphate insecticide, chlorpyrifos-methyl
    Raphael N'Guessan
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Malar J 9:44. 2010
    ..The most cost-effective and longest-lasting residual insecticide DDT is also the most environmentally persistent...
  23. pmc Assaying organochlorines in archived serum for a large, long-term cohort: implications of combining assay results from multiple laboratories over time
    Robert I Sholtz
    Child Health and Development Studies, Public Health Institute, Berkeley, CA 94709, USA
    Environ Int 37:709-14. 2011
    ..We sought to determine whether we could successfully combine assay results for DDT-related compounds and polychlorinated biphenyls (PCBs) in serum from the same birth cohort obtained from different ..
  24. ncbi Xenobiotic-induced TNF-alpha expression and apoptosis through the p38 MAPK signaling pathway
    Daniel E Frigo
    Center for Bioenvironmental Research, Molecular and Cellular Biology Program, Tulane University Health Science Center, New Orleans, LA 70112, USA
    Toxicol Lett 155:227-38. 2005
    Some xenobiotics, such as dichlorodiphenyltrichloroethane (DDT), bind to and activate estrogen receptors (ERs), eliciting estrogenic effects in both wildlife and humans...
  25. doi Correcting serum concentrations of organochlorine compounds by lipids: alternatives to the organochlorine/total lipids ratio
    Miquel Porta
    Institut Municipal d Investigació Mèdica Hospital del Mar, E 08003 Barcelona, Catalonia, Spain
    Environ Int 35:1080-5. 2009
    ..Our aim was to analyze the relationship between serum OC and TL in patients with pancreatic ductal adenocarcinoma (PDA), and to explore several alternatives to perform the OC lipid correction...
  26. pmc Additional selection for insecticide resistance in urban malaria vectors: DDT resistance in Anopheles arabiensis from Bobo-Dioulasso, Burkina Faso
    Christopher M Jones
    Vector Group, Liverpool School of Tropical Medicine, Liverpool, Merseyside, United Kingdom
    PLoS ONE 7:e45995. 2012
    ..l. adults emerging from a highly polluted site in the city centre (Dioulassoba) have a high prevalence of DDT resistance (percentage mortality after exposure to diagnostic dose=65.8% in the dry season and 70...
  27. ncbi Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding domains for pyrethroids and DDT
    P N R Usherwood
    School of Biology, The University of Nottingham, University Park, Nottingham, UK
    FEBS Lett 581:5485-92. 2007
    Mutations in the DIIS4-S5 linker and DIIS5 have identified hotspots of pyrethroid and DDT interaction with the Drosophila para sodium channel...
  28. ncbi Effects of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)-ethane (p,p'-DDT) on 3T3-L1 and 3T3-F442A adipocyte differentiation
    Maria J Moreno-Aliaga
    Department of Environmental Toxicology, Center for Environmental Health Sciences, University of California, Davis 95616, USA
    Biochem Pharmacol 63:997-1007. 2002
    Based upon our initial observations that 1,1,1-trichloro-2,2-bis(p-chlorophenyl)-ethane (p,p'-DDT) induces a concentration-dependent increase in 3T3-L1 adipocyte differentiation, the mechanism of the p,p'-DDT-induced adipocyte ..
  29. pmc Environmental organochlorine exposure as a potential etiologic factor in breast cancer
    M S Wolff
    Department of Community Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Environ Health Perspect 103:141-5. 1995
    ..The data are strongest for DDT. For PCBs, the results to date have been equivocal if not entirely negative...
  30. pmc DDT and malaria prevention: addressing the paradox
    Hindrik Bouwman
    School of Environmental Sciences and Development, North West University, Potchefstroom, South Africa
    Environ Health Perspect 119:744-7. 2011
    The debate regarding dichlorodiphenyltrichloroethane (DDT) in malaria prevention and human health is polarized and can be classified into three positions: anti-DDT, centrist-DDT, pro-DDT.
  31. pmc Malaria control insecticide residues in breast milk: the need to consider infant health risks
    Hindrik Bouwman
    School of Environmental Sciences and Development Zoology, North West University, Potchefstroom, South Africa
    Environ Health Perspect 117:1477-80. 2009
    ..Except for dichlorodiphenyltrichloroethane (DDT), safety of residues of other insecticides in breast milk has not been considered during World Health Organization ..
  32. ncbi Comparative effects of permethrin-impregnated bednets and DDT house spraying on survival rates and oviposition interval of Anopheles farauti No. 1 (Diptera:Culicidae) in Solomon Islands
    J L Hii
    Department of Public Health and Tropical Medicine, James Cook University, Townsville, QLD, Australia
    Ann Trop Med Parasitol 89:521-9. 1995
    ..Houses in one of the villages were sprayed with DDT, another village was unsprayed but its inhabitants used permethrin-treated bednets and the third village was left ..
  33. doi DDT and urogenital malformations in newborn boys in a malarial area
    Riana Bornman
    Department of Urology, University of Pretoria, Pretoria, South Africa
    BJU Int 106:405-11. 2010
    ..newborn boys from a malarial area currently sprayed with technical 1,1,1-trichloro-2,2-bis(4-chlorophenyl) ethane (DDT), as increased fetal oestrogenic or anti-androgenic exposure might be involved in the pathogenesis of increased ..
  34. pmc DDT and breast cancer in young women: new data on the significance of age at exposure
    Barbara A Cohn
    Child Health and Development Studies, Center for Research on Women s and Children s Health, Public Health Institute, Berkeley, California 94709, USA
    Environ Health Perspect 115:1406-14. 2007
    Previous studies of DDT and breast cancer assessed exposure later in life when the breast may not have been vulnerable, after most DDT had been eliminated, and after DDT had been banned.
  35. ncbi Dichlorodiphenyltrichloroethane (DDT) for indoor residual spraying in Africa: how can it be used for malaria control?
    Shobha Sadasivaiah
    Weill Cornell Medical College of Cornell University, Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Am J Trop Med Hyg 77:249-63. 2007
    ..a position statement promoting the use of indoor residual spraying (IRS) with dichlorodiphenyltrichloroethane (DDT) for malaria vector control in epidemic and endemic areas...
  36. pmc Body burdens of brominated flame retardants and other persistent organo-halogenated compounds and their descriptors in US girls
    Gayle C Windham
    CA Department of Public Health, DEODC, 850 Marina Bay Pkwy, Bldg P, Richmond, CA 94804, USA
    Environ Res 110:251-7. 2010
    ..Exposures to such chemicals may affect a number of health outcomes related to development and reproductive function...
  37. doi The role of the Aedes aegypti Epsilon glutathione transferases in conferring resistance to DDT and pyrethroid insecticides
    Nongkran Lumjuan
    Research Institute for Health Sciences, Chiang Mai University, 110 Intavaroros Road, Chiang Mai, 50200, Thailand
    Insect Biochem Mol Biol 41:203-9. 2011
    ..291, which maps to chromosome 2. One Epsilon GST, GSTE2, has previously been implicated in conferring resistance to DDT. The amino acid sequence of GSTE2 in an insecticide susceptible and a DDT resistant strain differs at five residues ..
  38. pmc Commentary: malaria control in the 1990s
    P I Trigg
    Division of Control of Tropical Diseases, World Health Organization, Geneva, Switzerland
    Bull World Health Organ 76:11-6. 1998
    ..1955 the Eighth World Health Assembly adopted a Global Malaria Eradication Campaign based on the widespread use of DDT against mosquitos and of antimalarial drugs to treat malaria and to eliminate the parasite in humans...
  39. pmc Developmental and environmental origins of breast cancer: DDT as a case study
    Barbara A Cohn
    Child Health and Development Studies, The Public Health Institute, Berkeley, CA 94709, United States
    Reprod Toxicol 31:302-11. 2011
    More than 20 studies of serum "DDT" and breast cancer have found little support for the hypothesis that exposure influences risk of breast cancer...
  40. doi Effect of polychlorinated biphenyls (PCBs) and 1,1,1-trichloro-2,2,-bis (4-chlorophenyl)-ethane (DDT) in follicular fluid on the results of in vitro fertilization-embryo transfer (IVF-ET) programs
    Simona Jirsová
    Department of Gynecology and Obstetrics, Charles University, First Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic
    Fertil Steril 93:1831-6. 2010
    ..To establish the effect of chlorinated organic compounds on fertility...
  41. ncbi Estrogens and environmental estrogens
    H Tapiero
    Laboratoire de Pharmacologie Cellulaire and Moléculaire, CNRS UMR 8612, Universite de Paris Sud, Faculte de Pharmacie, Chatenay Malabry, France
    Biomed Pharmacother 56:36-44. 2002
    ..environmental estrogens such as beta-hexachlorocyclohexane (beta-HCH), polychlorinated biphenyls (PCBs), o, p, p'DDT, 4-nonylphenol (NP) and phytoestrogens such as isoflavones or lignans, are more stable and remain in the body ..
  42. pmc Fungal infection counters insecticide resistance in African malaria mosquitoes
    Marit Farenhorst
    Laboratory of Entomology, Wageningen University and Research Centre, P O Box 8031, 6700 EH Wageningen, The Netherlands
    Proc Natl Acad Sci U S A 106:17443-7. 2009
    ..Our results show a high potential utility of fungal biopesticides for complementing existing vector control measures and provide products for use in resistance management strategies...
  43. ncbi Should DDT be banned by international treaty?
    C F Curtis
    London School of Hygiene and Tropical Medicine, Keppel Street, London, UK WC1E 7HT
    Parasitol Today 16:119-21. 2000
    The insecticide DDT has been an effective and affordable means of malaria control in many countries, but pressure for its use to be banned is mounting...
  44. pmc Extensive permethrin and DDT resistance in Anopheles arabiensis from eastern and central Sudan
    Yousif E Himeidan
    Entomology Unit, Faculty of Agriculture and Natural Resources, University of Kassala, New Halfa, Sudan
    Parasit Vectors 4:154. 2011
    ..This study assessed resistance to permethrin and DDT in seven populations of Anopheles arabiensis from Sudan.
  45. ncbi Occurrence and distribution of organochlorine pesticides (HCH and DDT) in sediments collected from East China Sea
    Rui qiang Yang
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
    Environ Int 31:799-804. 2005
    ..The levels and distribution patterns of the selected organochlorine pesticides (OCPs=p,p'-DDT, o,p'-DDT, p,p'-DDE, p,p'-DDD, alpha-, beta-, gamma- and delta-HCH) in samples were investigated by the technique ..
  46. pmc Prenatal concentrations of polychlorinated biphenyls, DDE, and DDT and overweight in children: a prospective birth cohort study
    Damaskini Valvi
    Centre for Research in Environmental Epidemiology, Barcelona, Spain
    Environ Health Perspect 120:451-7. 2012
    ..Recent experimental evidence suggests that prenatal exposure to endocrine-disrupting chemicals (EDCs) may increase postnatal obesity risk and that these effects may be sex or diet dependent...
  47. pmc Prenatal exposure to the major DDT metabolite 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and growth in boys from Mexico
    Lea A Cupul-Uicab
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 TW Alexander Dr, Research Triangle Park, NC 27709, USA
    Environ Res 110:595-603. 2010
    ..between prenatal DDE exposure and growth was evaluated in 788 boys from Chiapas, an area of Mexico where DDT was recently used. The median DDE levels in maternal serum at birth (2002-2003) were 2.7 microg/g lipid...
  48. ncbi Extension of indoor residual spraying for malaria control into high transmission settings in Africa
    Kate Kolaczinski
    Malaria Consortium Africa, P O Box 8045, Sturrock Road, Kampala, Uganda
    Trans R Soc Trop Med Hyg 101:852-3. 2007
    ..spraying (IRS) in malaria control in high transmission settings of sub-Saharan Africa and re-emphasises the role of DDT. We review the issues related to this change in recommendation...
  49. doi Organochlorine pesticides in the surface water and sediments from the Peacock River Drainage Basin in Xinjiang, China: a study of an arid zone in Central Asia
    Wei Chen
    Key Laboratory of Biogeology and Environmental Geology of the Ministry of Education, Wuhan 430074, People s Republic of China
    Environ Monit Assess 177:1-21. 2011
    ..All the analyzed organochlorine pesticides, except o,p'-DDT, were detected in sediments from the Peacock River; but in the water samples, only β-HCH, HCB, p,p'-DDD, and p,p'-..
  50. doi The role of cyclooxygenase-2-dependent signaling via cyclic AMP response element activation on aromatase up-regulation by o,p'-DDT in human breast cancer cells
    Eun Hee Han
    Department of Toxicology, College of Pharmacy, Chungnam National University, 220 Gung Dong, Daejeon 305 764, Yuseong Gu, South Korea
    Toxicol Lett 198:331-41. 2010
    o,p'-Dichlorodiphenyltrichloroethane (o,p'-DDT) is a DDT isomer and xenoestrogen that can induce inflammation and cancer. However, the effect of o,p'-DDT on aromatase is unclear...
  51. ncbi Insecticide susceptibility level of Anopheles arabiensis in two agrodevelopment localities in eastern Ethiopia
    M Balkew
    Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia
    Parassitologia 45:1-3. 2003
    ..The insecticides used were WHO discriminating doses of 4% DDT, 0.75% permethrin and 0.1% propoxur. The study revealed that 42.5% of the An...
  52. ncbi Inadvertent exposure to organochlorine pesticides DDT and derivatives in people from the Canary Islands (Spain)
    Manuel Zumbado
    Toxicology Unit, Department of Clinical Sciences, University of Las Palmas de Gran Canaria, P O Box 550, 35080, Las Palmas de Gran Canaria, Spain
    Sci Total Environ 339:49-62. 2005
    ..farming areas have been developed in these last decades, with greenhouses dedicated to intensive cultivation using DDT in huge amounts. In Spain, similarly to other European countries, DDT was banned in the late 1970s...
  53. doi Susceptibility of Anopheles gambiae s.l. to DDT, malathion, permethrin and deltamethrin in Ethiopia
    Alemayehu Abate
    Ethiopian Health and Nutrition Research Institute, Addis Ababa, Ethiopia
    Trop Med Int Health 16:486-91. 2011
    To assess the susceptibility/resistance level of Anopheles gambiae s.l. to DDT, malathion, permethrin and deltamethrin in different parts of Ethiopia.
  54. ncbi Historical review of malarial control in southern African with emphasis on the use of indoor residual house-spraying
    Musawenkosi L H Mabaso
    Malaria Research Programme, Medical Research Council, Durban, South Africa
    Trop Med Int Health 9:846-56. 2004
    Indoor residual house-spraying (IRS) mainly with dichlorodiphenyltrichloroethane (DDT) was the principal method by which malaria was eradicated or greatly reduced in many countries in the world between the 1940s and 1960s...
  55. ncbi Relation of DDT residues to plasma retinol, alpha-tocopherol, and beta-carotene during pregnancy and malaria infection: a case-control study in Karen women in northern Thailand
    W Stuetz
    Institute of Biological Chemistry and Nutrition, University of Hohenheim, 70599 Stuttgart, Germany
    Sci Total Environ 363:78-86. 2006
    Populations living in endemic malaria areas maybe exposed simultaneously to DDT and malaria infection. DDT may impair status of vitamins, which are implicated in the immunity and pathophysiology of malaria...
  56. pmc Genome-wide transcription profile of field- and laboratory-selected dichlorodiphenyltrichloroethane (DDT)-resistant Drosophila
    J H F Pedra
    Department of Entomology, Purdue University, West Lafayette, IN 47907 1158, USA
    Proc Natl Acad Sci U S A 101:7034-9. 2004
    ..only one gene, the cytochrome P450 enzyme Cyp6g1, is differentially transcribed in dichlorodiphenyltrichloroethane (DDT)-resistant vs...
  57. ncbi Susceptibility of sand flies to selected insecticides in North Africa and the Middle East
    G E Tetreault
    Vector Biology Research Program, US Naval Medical Research Unit Number Three, AE 09835, USA
    J Am Mosq Control Assoc 17:23-7. 2001
    ..Fifty, 90, and 99% lethal doses were calculated for bendiocarb, cyfluthrin, DDT, malathion, permethrin, and resmethrin on Phlebotomus bergeroti, P. langeroni, P. papatasi. and P. sergenti...
  58. pmc Resistance to DDT and pyrethroids and increased kdr mutation frequency in An. gambiae after the implementation of permethrin-treated nets in Senegal
    Mamadou O Ndiath
    Institut de Recherche pour le Developpement, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes UMR 198, Campus commun UCAD IRD de Hann, BP 1386, CP 18524 Dakar, Senegal
    PLoS ONE 7:e31943. 2012
    ..gambiae mosquitoes sampled in Dielmo (Senegal), in 2010, 2 years after the implementation of Long Lasting Insecticide-treated Nets (LLINs) and to report the evolution of kdr mutation frequency from 2006 to 2010...
  59. doi Mercury and DDT exposure risk to fish-eating human populations in Amazon
    Inês da Silva Rabitto
    Departamento de Biologia Celular, Setor de Ciencias Biologicas, Universidade Federal do Parana, Curitiba, Parana, Brazil
    Environ Int 37:56-65. 2011
    ..For total mercury, DDT and DDE quantifications and cholinesterase activity samples of the axial muscle were frozen at -20°C, and for ..
  60. doi Concentration of selected persistent organic pollutants in blood from delivering women in South Africa
    H B Rollin
    South African Medical Research Council, PO Box 87373, Houghton 2041, Johannesburg, South Africa
    Sci Total Environ 408:146-52. 2009
    ..28, 52, 99, 101, 105, 118, 138, 149, 153, 156, 170, 180, 183, 187, 194); six DDT metabolites (dichlordiphenyltrichloroethane p,p'-DDT and o,p'-DDT; diphenyldichloroethylene p,p'-DDE and o,p'-DDE, ..
  61. doi (-)-Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, reduces dichlorodiphenyl-trichloroethane (DDT)-induced cell death in dopaminergic SHSY-5Y cells
    Kwok Keung Tai
    The Parkinson s and Movement Disorder Research Laboratory, Long Beach Memorial Medical Center, 2801 Atlantic Ave, Long Beach, CA 90806, USA
    Neurosci Lett 482:183-7. 2010
    ..polyphenol, concentration-dependently (1 microM, 3 microM and 10 microM) reduced dichlorodiphenyl-trichloroethane (DDT) (100 microM)-induced cell death in dopaminergic neuroblastoma SHSY-5Y cells...
  62. pmc Organochlorine-mediated potentiation of the general coactivator p300 through p38 mitogen-activated protein kinase
    Melyssa R Bratton
    Department of Pharmacology, Tulane University Health Science Center, New Orleans, LA 70112, USA
    Carcinogenesis 30:106-13. 2009
    ..We have previously shown that the organochlorine pesticide dichlorodiphenyltrichloroethane (DDT) stimulates activator protein-1 activity through the p38 mitogen-activated protein kinase (MAPK)...
  63. doi Synergistic genotoxicity caused by low concentration of titanium dioxide nanoparticles and p,p'-DDT in human hepatocytes
    Yun Shi
    MOE Key Laboratory of Environment and Health, Institute of Environmental Medicine, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
    Environ Mol Mutagen 51:192-204. 2010
    The use of titanium dioxide nanoparticles (nano-TiO(2)) for the degradation of dichlorodiphenyltrichloroethane (p,p'-DDT) increases the risk of exposure to trace nano-TiO(2) and p,p'-DDT mixtures...
  64. doi Recognition and detoxification of the insecticide DDT by Drosophila melanogaster glutathione S-transferase D1
    Wai Yee Low
    Department of Genetics, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Melbourne, Victoria 3010, Australia
    J Mol Biol 399:358-66. 2010
    GSTD1 is one of several insect glutathione S-transferases capable of metabolizing the insecticide DDT. Here we use crystallography and NMR to elucidate the binding of DDT and glutathione to GSTD1...
  65. doi DDT contamination from indoor residual spraying for malaria control
    J C van Dyk
    Department of Urology, University of Pretoria, Pretoria 0001, South Africa
    Sci Total Environ 408:2745-52. 2010
    The insecticide DDT is still used in specific areas of South Africa for indoor residual spray (IRS) to control malaria vectors...
  66. doi On the rate of decline of persistent organic contaminants in lake trout (Salvelinus namaycush) from the Great Lakes, 1970-2003
    Daniel L Carlson
    Environmental Health Sciences MMC 807, School of Public Health University of Minnesota, Minneapolis, Minnesota 55455, USA
    Environ Sci Technol 44:2004-10. 2010
    ..Half-lives of oxychlordane, polychlorinated biphenyls (PCBs), and dichloro-diphenyl-trichlorethane (DDT) and its metabolites were typically 3-6 years until the mid 1980s; since then, the newest data confirm half-lives ..
  67. ncbi Impregnated nets or ddt residual spraying? Field effectiveness of malaria prevention techniques in solomon islands, 1993-1999
    Mead Over
    Development Research Group, World Bank, Washington, District of Columbia 20433, USA
    Am J Trop Med Hyg 71:214-23. 2004
    ..The control program used a combination of methods including DDT residual house spraying and insecticide-treated mosquito nets...
  68. ncbi In utero exposure to background concentrations of DDT and cognitive functioning among preschoolers
    Nuria Ribas-Fito
    Respiratory and Environmental Health Research Unit, Institut Municipal Investigació Mèdica IMIM, Barcelona, Catalonia, Spain
    Am J Epidemiol 164:955-62. 2006
    p,p'-DDT (bis[p-chlorophenyl]-1,1,1-trichloroethane) is a persistent organochlorine compound that has been used worldwide as an insecticide...
  69. doi DDT residues in water, sediment, domestic and indigenous biota from a currently DDT-sprayed area
    I E J Barnhoorn
    Department of Urology, Faculty of Health Sciences, P O Box 667, University of Pretoria, Pretoria, South Africa
    Chemosphere 77:1236-41. 2009
    b>DDT is used for indoor residual spraying (IRS) in Limpopo Province, northern South Africa to control malaria. Through IRS, DDT may reach the outdoor environment via dust and air and from possible spillages during application...
  70. pmc Characterization of the de novo biosynthetic enzyme of platelet activating factor, DDT-insensitive cholinephosphotransferase, of human mesangial cells
    Alexandros Basilios Tsoupras
    Faculty of Chemistry, School of Sciences, National and Kapodistrian University of Athens, Panepistimioupolis, 15771 Athens, Greece
    Mediators Inflamm 2007:27683. 2007
    ..The results indicated that the above compounds can influence PAF-CPT activity of HMC...
  71. ncbi Operational impact of DDT reintroduction for malaria control on Anopheles arabiensis in Mozambique
    M Coleman
    Malaria Research Programme, Medical Research Council, Ridge Rd, Durban, South Africa
    J Med Entomol 45:885-90. 2008
    ..and nationally funded malaria control programs, and affirmation by World Health Organization (WHO) that DDT is appropriate for use in the absence of longer lasting insecticide formulations in some malaria endemic settings, ..
  72. doi A dehydrochlorinase-based pH change assay for determination of DDT in sprayed surfaces
    Evangelia Morou
    Vector Research, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK
    Anal Biochem 378:60-4. 2008
    ..enzyme for this parasite vector, was employed to produce a highly specific assay for the determination of DDT [1,1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene]...
  73. ncbi The use of a non-lethal tool for evaluating toxicological hazard of organochlorine contaminants in Mediterranean cetaceans: new data 10 years after the first paper published in MPB
    M Cristina Fossi
    Department of Environmental Sciences, Siena University, Via delle Cerchia 3, Via Mattioli 4, 53100 Siena, Italy
    Mar Pollut Bull 46:972-82. 2003
    ..High concentrations of DDT metabolites and PCB congeners (known as EDCs) were found in the different Mediterranean species (Stenella ..
  74. ncbi Polychlorobiphenyls and other organochlorine compounds in human follicular fluid
    Elena De Felip
    Laboratory of Comparative Toxicology and Ecotoxicology, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Chemosphere 54:1445-9. 2004
    ..dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs), 1,1,1-trichloro-2,2-bis(4-chlorophenyl)-ethane (p,p'-DDT) and its metabolites, and hexachlorobenzene (HCB) was investigated...
  75. ncbi DDT indoor residual spray, still an effective tool to control Anopheles fluviatilis-transmitted Plasmodium falciparum malaria in India
    K Gunasekaran
    Vector Control Research Centre, Medical Complex, Indira Nagar, Pondicherry 605 006, India
    Trop Med Int Health 10:160-8. 2005
    ..culicifacies investigated the impact of dichlorodiphenyl trichloroethane (DDT) indoor residual spraying, in view of the ongoing discussion on phasing out DDT in India...
  76. doi Structure of an insect epsilon class glutathione S-transferase from the malaria vector Anopheles gambiae provides an explanation for the high DDT-detoxifying activity
    Yujun Wang
    Laboratory for Structural Biology, Department of Chemistry, Graduate Program of Biotechnology, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    J Struct Biol 164:228-35. 2008
    ..gambiae, insect-specific epsilon class GSTs are associated with resistance to the organochlorine insecticide DDT [1,1,1-trichloro-2,2-bis-(p-chlorophenyl)ethane]...
  77. ncbi A prospective study of serum DDT and progesterone and estrogen levels across the menstrual cycle in nulliparous women of reproductive age
    Melissa J Perry
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 164:1056-64. 2006
    The authors explored whether exposure to 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) and its isomers and metabolites affects female reproductive hormones characterized by urinary pregnanediol-3-glucuronide (PdG) and estrone ..
  78. pmc Insecticide susceptibility of Phlebotomus argentipes in visceral leishmaniasis endemic districts in India and Nepal
    Diwakar Singh Dinesh
    Rajendra Memorial Research Institute of Medical Sciences, Patna, India
    PLoS Negl Trop Dis 4:e859. 2010
    To investigate the DDT and deltamethrin susceptibility of Phlebotomus argentipes, the vector of Leishmania donovani, responsible for visceral leishmaniasis (VL), in two countries (India and Nepal) with different histories of insecticide ..
  79. pmc Monitoring the operational impact of insecticide usage for malaria control on Anopheles funestus from Mozambique
    Sonia L R Casimiro
    National Institute of Health, Av Eduardo Mondlane Salvador Allende, Maputo, Mozambique, P O Box 264, Liverpool, UK
    Malar J 6:142. 2007
    ..This combined with the affirmation by WHO that DDT is appropriate for use in the absence of longer lasting insecticide formulations in some malaria endemic settings, ..
  80. doi Comparing water, bovine milk, and indoor residual spraying as possible sources of DDT and pyrethroid residues in breast milk
    Barbara Sereda
    Agricultural Research Council, Plant Protection Research Institute, Pretoria, South Africa
    J Toxicol Environ Health A 72:842-51. 2009
    ..milk is of major concern, especially in malaria control areas where 1,1,1-trichloro-2,2-bis(4-chlorophenyl) ethane (DDT) is currently used as indoor residual spray (IRS)...
  81. doi Reduced susceptibility to DDT in field populations of Anopheles quadriannulatus and Anopheles arabiensis in Malawi: evidence for larval selection
    T Mzilahowa
    Malawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi
    Med Vet Entomol 22:258-63. 2008
    ..The results indicate full susceptibility to permethrin, deltamethrin and malathion, but reduced susceptibility to DDT in one sample from Thom (LT(50) of 8.39 min for females and 25.09 min for males)...
  82. ncbi Relationship between kdr mutation and resistance to pyrethroid and DDT insecticides in natural populations of Anopheles gambiae
    Lisa Reimer
    Department of Entomology and Center for Vectorborne Diseases, University of California Davis, Davis, CA 95616, USA
    J Med Entomol 45:260-6. 2008
    ..locus in the voltage-gated sodium channel gene are known to confer knockdown resistance (kdr) to pyrethroids and DDT. Kdr-e involves a leucine-serine substitution, and it was until recently thought to be restricted to East Africa, ..
  83. ncbi Induction of inducible nitric oxide synthase and proinflammatory cytokines expression by o,p'-DDT in macrophages
    Ji Young Kim
    Department Pharmacy, College of Pharmacy, Research Center for Proteineous Materials, Chosun University, 375 Seosuk dong, Kwangju 501 759, South Korea
    Toxicol Lett 147:261-9. 2004
    ..1,1,1 -Trichloro-2-(p-chlorophenyl)-2-(o-chlorophenyl)ethane (o,p'-DDT) has been reported to possess immunomodulatory properties activity...
  84. doi DDT, DDE and DDD in human milk from South Africa
    Jonathan Okechukwu Okonkwo
    Tshwane University of Technology, Pretoria, South Africa
    Bull Environ Contam Toxicol 81:348-54. 2008
    ..b>DDT and its metabolites were extracted from the milk samples using diethyl ether...
  85. doi Genotoxic effects of p,p'-DDT (1,1,1-trichloro-2,2-bis-(chlorophenyl)ethane) and its metabolites in Zebra mussel (D. polymorpha) by SCGE assay and micronucleus test
    Andrea Binelli
    Department of Biology, University of Milan, Via Celoria 26, Milan, Italy
    Environ Mol Mutagen 49:406-15. 2008
    This is the first study to evaluate the potential genotoxicity of p,p'-DDT (1,1,1-trichloro-2,2-bis-(chlorophenyl)ethane) and its metabolites (p,p'-DDD and p,p'-DDE) in the sentinel mollusc Zebra mussel (Dreissena polymorpha)...
  86. ncbi Effects of physiological conditioning on behavioral avoidance by using a single age group of Aedes aegypti exposed to deltamethrin and DDT
    Suppaluck Polsomboon
    Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900 Thailand
    J Med Entomol 45:251-9. 2008
    The behavioral and physiological responses of 6-d-old Aedes aegypti (L.) adult females exposed to deltamethrin and DDT were characterized using a free-choice excito-repellency test system...
  87. ncbi Human-landing patterns of Anopheles dirus sensu lato (Diptera: Culicidae) in experimental huts treated with DDT or deltamethrin
    Naritsara Malaithong
    Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand
    J Med Entomol 47:823-32. 2010
    Anopheles dirus females landing on humans inside experimental huts treated with residual applications of DDT or deltamethrin were observed during the wet season in Pu Teuy Village, Kanchanaburi Province, western Thailand...
  88. ncbi Insecticide resistance in Anopheles funestus (Diptera: Culicidae) from Mozambique
    S Casimiro
    National Malaria Control Program, National Direction of Health, Av Eduardo Mondlane Salvador Allende, P O Box 264, Maputo, Mozambique
    J Med Entomol 43:267-75. 2006
    ..An. funestus from all localities remained fully susceptible to DDT and the organophosphorus insecticide malathion. A high level of pyrethroid resistance was detected in An...
  89. ncbi Investigating the global fate of DDT: model evaluation and estimation of future trends
    Urs Schenker
    Institute for Chemical and Bioengineering, ETH Zurich, CH 8093 Zurich, Switzerland
    Environ Sci Technol 42:1178-84. 2008
    ..environmental fate model CliMoChem has been used to calculate concentrations of dichlorodiphenyltrichloroethane (DDT) and its degradation products in the environment...
  90. doi Characterization of knockdown resistance in DDT- and pyrethroid-resistant Culex quinquefasciatus populations from Sri Lanka
    Charles S Wondji
    Liverpool School of Tropical Medicine, Liverpool, UK
    Trop Med Int Health 13:548-55. 2008
    b>DDT and pyrethroid resistance in Culex quinquefasciatus have been previously reported in Sri Lanka, but the mechanisms involved have yet to be characterized...
  91. ncbi Chlorfenapyr: a pyrrole insecticide for the control of pyrethroid or DDT resistant Anopheles gambiae (Diptera: Culicidae) mosquitoes
    P Boko
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Acta Trop 102:69-78. 2007
    ..Performance against An. gambiae bearing kdr (pyrethroid and DDT resistance) or Ace-1(R) insensitive acetylcholinesterase (organophosphate and carbamate resistance) mechanisms was ..
  92. pmc WHO recommends DDT to control malaria
    Christiane Rehwagen
    BMJ 333:622. 2006
  93. ncbi Risk assessment through dietary intake of total diet contaminated with pesticide residues in Punjab, India, 1999-2002
    R S Battu
    Pesticide Residue Laboratory, Department of Entomology, Punjab Agricultural University, Ludhiana, India
    Ecotoxicol Environ Saf 62:132-9. 2005
    ..The results revealed low dietary intake of levels of Sigma-dichlorodiphenyltrichloroethane (DDT) and which were almost comparable to levels reported in developed countries...
  94. ncbi Insecticide resistance in Anopheles arabiensis and Anopheles gambiae from Mozambique
    S Casimiro
    National Malaria Control Program, National Direction of Health, Av Eduardo Mondlane Salvador Allende, P O Box 264, Maputo, Mozambique
    J Med Entomol 43:276-82. 2006
    ..An. gambiae s.s. from all localities remained fully susceptible to DDT and the organophosphorus insecticide malathion...
  95. pmc DDT stalemate stymies malaria control initiative
    Katie Lewis
    CMAJ 179:999-1000. 2008
  96. doi The adverse effect of dichlorodiphenyltrichloroethane (DDT) and its metabolite (DDE) on the secretion of prostaglandins and oxytocin in bovine cultured ovarian and endometrial cells
    Michal Wrobel
    Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima Street 10, 10 747 Olsztyn, Poland
    Reprod Toxicol 27:72-8. 2009
    The influence of chlorinated hydrocarbon insecticide-dichlorodiphenyltrichloroethane (DDT) and its metabolite (DDE) on the uterine prostaglandin (PGF2alpha and PGE2) and ovarian oxytocin (OT) secretion was investigated...
  97. pmc Influence of glutathione S-transferase polymorphisms on cognitive functioning effects induced by p,p'-DDT among preschoolers
    Eva Morales
    Center for Research in Environmental Epidemiology, Barcelona, Spain
    Environ Health Perspect 116:1581-5. 2008
    Early-life exposure to p,p'-DDT [2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane] is associated with a decrease in cognitive skills among preschoolers at 4 years of age...
  98. ncbi Pesticides interfere with the nongenomic action of a progestogen on meiotic maturation by binding to its plasma membrane receptor on fish oocytes
    S Das
    Department of Internal Medicine, Yale University, School of Medicine, VA Medical Center, West Haven, CT 06516, USA
    Endocrinology 140:1953-6. 1999
    ....
  99. ncbi Development of nanomechanical biosensors for detection of the pesticide DDT
    Mar Alvarez
    Biosensor Group Centro, Instituto de Microelectrónica de Madrid CNM CSIC, Conscjo Superior de, Investigaciones Cienti ficas, Centro Nacional de Microelectronica, Isaac Newton 8 PTM, Tres Cantos, 28760, Madrid, Spain
    Biosens Bioelectron 18:649-53. 2003
    ..use of a novel technique for detection of the organochlorine insecticide compound dichlorodiphenyltrichloroethane (DDT) by measuring the nanometer-scale bending of a microcantilever produced by differential surface stress...
  100. doi Exposure to persistent organic pollutants (POPs) and DNA damage as an indicator of environmental stress in fish of different feeding habits of Coatzacoalcos, Veracruz, Mexico
    Donaji J González-Mille
    Departamento de Toxicologia Ambiental, Facultad de Medicina, Universidad Autonoma de San Luis Potosi, Avenida Venustiano Carranza 2405, Col Lomas Los Filtros, San Luis Potosi, SLP, CP 78210, Mexico
    Ecotoxicology 19:1238-48. 2010
    ..tissue were hexachlorobenzene (HCB), α-, β-, γ-hexachlorocyclohexane (HCH), dichlorodiphenyltrichloroethane (DDT), dichlorodiphenyldichloroethylene (DDE), mirex and polychlorinated biphenyls (PCBs)...
  101. ncbi Persistence of DDT, malathion & deltamethrin resistance in Anopheles culicifacies after their sequential withdrawal from indoor residual spraying in Surat district, India
    K Raghavendra
    National Institute of Malaria Research ICMR, New Delhi, India
    Indian J Med Res 132:260-4. 2010
    Under the national antimalaria programme DDT was introduced in early 1950s for vector control and later hexachloro cyclohexane (HCH) followed by malathion and recently synthetic pyrethroids in 1990s to manage the insecticide resistance ..

Research Grants70

  1. Organochlorine pesticide, PCBs, and Parkinsons
    Alberto Ascherio; Fiscal Year: 2007
    ..1) That higher plasma levels of para, para-dichlorodiphenyl dichloroethene [p,p-DDE], the major metabolite of DDT, dieldrin, hexachlorobenzene (HCB), beta-hexachlorocyclohexane (HCH), heptachlor, heptachlor epoxide, trans-..
  2. Fetal exposure to environmental toxins & infant outcome
    Enrique Ostrea; Fiscal Year: 2006
    ..spectrometry for the following pesticides and their metabolites: propoxur, transfluthrin, Malathion, DDT, chlorpyrifos, bioallethrin, pretilachlor, lindane, cyfluthrin and cypermethrin...
  3. Maternal Pesticide Exposure and Pregnancy Outcomes
    Russ Hauser; Fiscal Year: 2009
    Although the use of polychlorinated biphenyls (PCBs) and many of the chlorinated pesticides, including DDT, are now prohibited or restricted, there remains concern over their potential human health effects because they persist in the ..
  4. Maternal Pesticide Exposure and Pregnancy Outcomes
    Russ Hauser; Fiscal Year: 2007
    Although the use of polychlorinated biphenyls (PCBs) and many of the chlorinated pesticides, including DDT, are now prohibited or restricted, there remains concern over their potential human health effects because they persist in the ..
  5. MODE OF ACTION OF INSECTICIDES--ELECTROPHYSIOLOGY
    Toshio Narahashi; Fiscal Year: 1993
    ..Two classes of insecticides will be studied. One class includes pyrethroids and DDT which are different in chemical structure but are similar in the mode of action...
  6. Organochlorine and Gene Expression of Sex Steroids in a Multigenerational Cohort
    Janet Rose Osuch; Fiscal Year: 2010
    ..in F1 generation females, depending on estimated levels of in-utero exposure to maternal blood levels of PCBs and DDT. The proposed analysis will consist of age-appropriate telephone interviews to ascertain a medical history, an ..
  7. Organochlorine and Gene Expression of Sex Steroids in a Multigenerational Cohort
    Janet Osuch; Fiscal Year: 2009
    ..in F1 generation females, depending on estimated levels of in-utero exposure to maternal blood levels of PCBs and DDT. The proposed analysis will consist of age-appropriate telephone interviews to ascertain a medical history, an ..
  8. Xenobiotics and Breast Epithelial Cell-ECM Signaling
    Raymond Novak; Fiscal Year: 2005
    ..Treatment of cells with p,p'-DDT results in increased delta-catenin levels relative to controls, whereas Kepone decreases alpha-catenin expression 2-..
  9. DDT, Endocrine Disruption and Reproductive Outcomes
    Xiaobin Wang; Fiscal Year: 2003
    ..Both animal and in vitro studies support the hypothesis that dichlorodiphenyl trichloroethane (DDT) and its metabolites are potentially important human reproductive toxins...
  10. Insecticide resistance in Africa Malaria mosquitoes
    Maureen Coetzee; Fiscal Year: 2004
    ..Compounding factors include the following. 1) Mozambique will not allow the use of DDT for house spraying and therefore will not achieve 100% eradication of the vector species An...
  11. ORGANOCHLORINES AND METALS IN NEW YORK AND THE HUDSON
    Philip Landrigan; Fiscal Year: 2006
    ..densely populated, heavily industrialized region that is contaminated by a complex mix of organochlorines - PCBs, DDT, chlordane, dieldrin, and dioxins - as well as by heavy metals, especially lead and mercury...
  12. Environmental Endocrine Disruptors and Human Sperm Chromosomal Abnormalities
    Melissa Perry; Fiscal Year: 2010
    ..between sperm aneuploidy and common environmental exposures, specifically polychlorinated biphenyls (PCBs), DDT, organophosphates (OPs), and pyrethroids (PYRs)...
  13. Extreme Ammonia Tolerance Mechanisms: A Model Vertebrate
    Patrick Walsh; Fiscal Year: 2004
    ..In particular, liver damage due to exposure to toxicants such as carbon tetrachloride, toluene, DDT, heptachlor, etc...
  14. Development of a Field Applicable Screening Tool (FAST) kit for detecting resista
    Martin Donnelly; Fiscal Year: 2009
    ..insecticides that are used for indoor residual spraying (IRS) for malaria and filariasis namely an organochloride (DDT), a carbamate (Bendiocarb) and a class II pyrethroid (?-cyhalothrin)...
  15. Development of a Field Applicable Screening Tool (FAST) kit for detecting resista
    MARTIN JAMES DONNELLY; Fiscal Year: 2010
    ..insecticides that are used for indoor residual spraying (IRS) for malaria and filariasis namely an organochloride (DDT), a carbamate (Bendiocarb) and a class II pyrethroid (?-cyhalothrin)...
  16. Pilot-scale Research of Novel Amendment Delivery for in-situ Sediment Remediation
    Upal Ghosh; Fiscal Year: 2007
    ..This field research project will be carried out at two PCB/DDT-impacted sensitive wetland sites...
  17. Pilot-scale Research of Novel Amendment Delivery for in-situ Sediment Remediation
    Upal Ghosh; Fiscal Year: 2009
    ..This field research project will be carried out at two PCB/DDT-impacted sensitive wetland sites...
  18. Pilot-scale Research of Novel Amendment Delivery for in-situ Sediment Remediation
    Upal Ghosh; Fiscal Year: 2009
    ..This field research project will be carried out at two PCB/DDT-impacted sensitive wetland sites...
  19. Polybrominated Biphenyls and Cancer Risk
    KARIN ROSENBLATT; Fiscal Year: 2007
    ..as polybrominated diphenyl ether (PBDEs), polychlorinated biphenyls (PCBs), and organochlorine pesticides (such as DDT and DDE) have also been thought to have this property...
  20. A New Nano Based Real-Time Mycotoxin Detector
    NICHOLAS SMILANICH; Fiscal Year: 2007
    ..The substance is so toxic that it is one of 19 contaminants-along with mercury and DDT-for which the U.S...
  21. TRANSMEMBRANE SIGNALLING IN SMOOTH MUSCLE CELL LINES
    GEORGE DUBYAK; Fiscal Year: 1991
    ..that micromolar concentrations of extracellular ATP can activate rapid increases in cytosolic (Ca2+) in the DDT-1 smooth muscle cell line derived from a leiomyosarcoma of hamster vas deferens...