ddt

Summary

Summary: A polychlorinated pesticide that is resistant to destruction by light and oxidation. Its unusual stability has resulted in difficulties in residue removal from water, soil, and foodstuffs. This substance may reasonably be anticipated to be a carcinogen: Fourth Annual Report on Carcinogens (NTP-85-002, 1985). (From Merck Index, 11th ed)

Top Publications

  1. ncbi Dichlorodiphenyltrichloroethane (DDT) for indoor residual spraying in Africa: how can it be used for malaria control?
    Shobha Sadasivaiah
    Weill Cornell Medical College of Cornell University, Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Am J Trop Med Hyg 77:249-63. 2007
  2. pmc Additional selection for insecticide resistance in urban malaria vectors: DDT resistance in Anopheles arabiensis from Bobo-Dioulasso, Burkina Faso
    Christopher M Jones
    Vector Group, Liverpool School of Tropical Medicine, Liverpool, Merseyside, United Kingdom
    PLoS ONE 7:e45995. 2012
  3. pmc The Anopheles gambiae detoxification chip: a highly specific microarray to study metabolic-based insecticide resistance in malaria vectors
    Jean Philippe David
    Vector Research Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L35QA, United Kingdom
    Proc Natl Acad Sci U S A 102:4080-4. 2005
  4. ncbi A single p450 allele associated with insecticide resistance in Drosophila
    P J Daborn
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Science 297:2253-6. 2002
  5. pmc Prenatal concentrations of polychlorinated biphenyls, DDE, and DDT and overweight in children: a prospective birth cohort study
    Damaskini Valvi
    Centre for Research in Environmental Epidemiology, Barcelona, Spain
    Environ Health Perspect 120:451-7. 2012
  6. pmc Identification and validation of a gene causing cross-resistance between insecticide classes in Anopheles gambiae from Ghana
    Sara N Mitchell
    Vector Group, Liverpool School of Tropical Medicine, Liverpool L35QA, United Kingdom
    Proc Natl Acad Sci U S A 109:6147-52. 2012
  7. ncbi Does kdr genotype predict insecticide-resistance phenotype in mosquitoes?
    Martin J Donnelly
    Vector Group, Liverpool School of Tropical Medicine, Liverpool L35QA, UK
    Trends Parasitol 25:213-9. 2009
  8. ncbi Historical review of malarial control in southern African with emphasis on the use of indoor residual house-spraying
    Musawenkosi L H Mabaso
    Malaria Research Programme, Medical Research Council, Durban, South Africa
    Trop Med Int Health 9:846-56. 2004
  9. pmc Identification of a novel class of insect glutathione S-transferases involved in resistance to DDT in the malaria vector Anopheles gambiae
    H Ranson
    School of Biosciences, Main College, Cardiff University, PO Box 915, Cardiff CF10 3TL, Wales, UK
    Biochem J 359:295-304. 2001
  10. ncbi Insecticide resistance and its association with target-site mutations in natural populations of Anopheles gambiae from eastern Uganda
    Urvashi Ramphul
    Vector Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Trans R Soc Trop Med Hyg 103:1121-6. 2009

Detail Information

Publications362 found, 100 shown here

  1. ncbi Dichlorodiphenyltrichloroethane (DDT) for indoor residual spraying in Africa: how can it be used for malaria control?
    Shobha Sadasivaiah
    Weill Cornell Medical College of Cornell University, Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Am J Trop Med Hyg 77:249-63. 2007
    ..a position statement promoting the use of indoor residual spraying (IRS) with dichlorodiphenyltrichloroethane (DDT) for malaria vector control in epidemic and endemic areas...
  2. pmc Additional selection for insecticide resistance in urban malaria vectors: DDT resistance in Anopheles arabiensis from Bobo-Dioulasso, Burkina Faso
    Christopher M Jones
    Vector Group, Liverpool School of Tropical Medicine, Liverpool, Merseyside, United Kingdom
    PLoS ONE 7:e45995. 2012
    ..l. adults emerging from a highly polluted site in the city centre (Dioulassoba) have a high prevalence of DDT resistance (percentage mortality after exposure to diagnostic dose=65.8% in the dry season and 70...
  3. pmc The Anopheles gambiae detoxification chip: a highly specific microarray to study metabolic-based insecticide resistance in malaria vectors
    Jean Philippe David
    Vector Research Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L35QA, United Kingdom
    Proc Natl Acad Sci U S A 102:4080-4. 2005
    ..The applications of this detox chip and its potential contribution to malaria vector insecticide resistance management programs are discussed...
  4. ncbi A single p450 allele associated with insecticide resistance in Drosophila
    P J Daborn
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Science 297:2253-6. 2002
    ..Here, via microarray analysis of all P450s in Drosophila melanogaster, we show that DDT-R, a gene conferring resistance to DDT, is associated with overtranscription of a single cytochrome P450 gene, ..
  5. pmc Prenatal concentrations of polychlorinated biphenyls, DDE, and DDT and overweight in children: a prospective birth cohort study
    Damaskini Valvi
    Centre for Research in Environmental Epidemiology, Barcelona, Spain
    Environ Health Perspect 120:451-7. 2012
    ..Recent experimental evidence suggests that prenatal exposure to endocrine-disrupting chemicals (EDCs) may increase postnatal obesity risk and that these effects may be sex or diet dependent...
  6. pmc Identification and validation of a gene causing cross-resistance between insecticide classes in Anopheles gambiae from Ghana
    Sara N Mitchell
    Vector Group, Liverpool School of Tropical Medicine, Liverpool L35QA, United Kingdom
    Proc Natl Acad Sci U S A 109:6147-52. 2012
    ..The gene-expression profile of a highly DDT-resistant population of A. gambiae s.s. from Ghana was characterized using a unique whole-genome microarray...
  7. ncbi Does kdr genotype predict insecticide-resistance phenotype in mosquitoes?
    Martin J Donnelly
    Vector Group, Liverpool School of Tropical Medicine, Liverpool L35QA, UK
    Trends Parasitol 25:213-9. 2009
    ..We assert that the link between kdr genotype and DDT- and pyrethroid-susceptibility phenotype is clear...
  8. ncbi Historical review of malarial control in southern African with emphasis on the use of indoor residual house-spraying
    Musawenkosi L H Mabaso
    Malaria Research Programme, Medical Research Council, Durban, South Africa
    Trop Med Int Health 9:846-56. 2004
    Indoor residual house-spraying (IRS) mainly with dichlorodiphenyltrichloroethane (DDT) was the principal method by which malaria was eradicated or greatly reduced in many countries in the world between the 1940s and 1960s...
  9. pmc Identification of a novel class of insect glutathione S-transferases involved in resistance to DDT in the malaria vector Anopheles gambiae
    H Ranson
    School of Biosciences, Main College, Cardiff University, PO Box 915, Cardiff CF10 3TL, Wales, UK
    Biochem J 359:295-304. 2001
    ..gambiae map to a region of the genome on chromosome 3R that contains a major DDT [1,1,1-trichloro-2,2-bis-(p-chlorophenyl)ethane] resistance gene, suggesting that this gene family is involved in ..
  10. ncbi Insecticide resistance and its association with target-site mutations in natural populations of Anopheles gambiae from eastern Uganda
    Urvashi Ramphul
    Vector Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Trans R Soc Trop Med Hyg 103:1121-6. 2009
    ..larvae sampled from two ecologically distinct breeding sites and exposed to WHO discriminating concentrations of DDT, permethrin, deltamethrin, bendiocarb and malathion. Survival rates to DDT were as high as 85...
  11. ncbi Relationship between kdr mutation and resistance to pyrethroid and DDT insecticides in natural populations of Anopheles gambiae
    Lisa Reimer
    Department of Entomology and Center for Vectorborne Diseases, University of California Davis, Davis, CA 95616, USA
    J Med Entomol 45:260-6. 2008
    ..locus in the voltage-gated sodium channel gene are known to confer knockdown resistance (kdr) to pyrethroids and DDT. Kdr-e involves a leucine-serine substitution, and it was until recently thought to be restricted to East Africa, ..
  12. pmc Resistance to DDT in an urban setting: common mechanisms implicated in both M and S forms of Anopheles gambiae in the city of Yaoundé Cameroon
    Billy Fossog Tene
    Laboratoire de Recherche sur le Paludisme, Organisation de Coordination pour la Lutte Contre les Endemies en Afrique Centrale, Yaounde, Cameroon
    PLoS ONE 8:e61408. 2013
    ..by the M and S molecular forms of Anopheles gambiae and both are resistant to the pyrethroid insecticides and DDT. Mutations in the target site of these insecticides, present at a high frequency in malaria vectors in this city, ..
  13. ncbi Pyrethroid and DDT cross-resistance in Aedes aegypti is correlated with novel mutations in the voltage-gated sodium channel gene
    C Brengues
    Laboratoire de Lutte contre les Insectes Nuisibles, Institut de Recherche pour le Developpment, Montpellier, France
    Med Vet Entomol 17:87-94. 2003
    ..Two laboratory strains, Bora (French Polynesia) and AEAE, were both susceptible to DDT and permethrin; all other strains, except Larentuka (Indonesia) and Bouaké (Ivory Coast), contained individual ..
  14. ncbi DDT, pyrethrins, pyrethroids and insect sodium channels
    T G E Davies
    Biological Chemistry Division, Rothamsted Research, Hertfordshire, UK
    IUBMB Life 59:151-62. 2007
    ..b>DDT, the pyrethrins and the synthetic pyrethroids (the latter currently accounting for around 17% of the world ..
  15. pmc Comparison of house spraying and insecticide-treated nets for malaria control
    C F Curtis
    London School of Hygiene and Tropical Medicine, London WC1E 7HT, England
    Bull World Health Organ 78:1389-400. 2000
    ..pyrethroid-treated nets were at least as efficacious as house spraying with dichlorodiphenyltrichloroethane (DDT), malathion or a pyrethroid...
  16. ncbi A significant increase in kdr in Anopheles gambiae is associated with an intensive vector control intervention in Burundi highlands
    Natacha Protopopoff
    Department of Parasitology, Prince Leopold Institute of Tropical Medicine, Antwerp, Belgium
    Trop Med Int Health 13:1479-87. 2008
    ..l.) was determined for six consecutive years within the framework of a vector control programme. Findings were also linked with the insecticide resistance status observed with bioassay in An. gambiae s.l. and An. funestus...
  17. pmc DDT and malaria prevention: addressing the paradox
    Hindrik Bouwman
    School of Environmental Sciences and Development, North West University, Potchefstroom, South Africa
    Environ Health Perspect 119:744-7. 2011
    The debate regarding dichlorodiphenyltrichloroethane (DDT) in malaria prevention and human health is polarized and can be classified into three positions: anti-DDT, centrist-DDT, pro-DDT.
  18. ncbi Elevated activity of an Epsilon class glutathione transferase confers DDT resistance in the dengue vector, Aedes aegypti
    Nongkran Lumjuan
    Vector Research Group, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK
    Insect Biochem Mol Biol 35:861-71. 2005
    ..In the mosquito, Anopheles gambiae, increased expression of an Epsilon class GST, GSTE2, confers resistance to DDT. We have identified eight GST genes in the dengue vector, Aedes aegypti...
  19. pmc DDT and pyrethroid resistance in Anopheles arabiensis from South Africa
    Luisa Nardini
    Division of the National Health Laboratory Services, Vector Control Reference Laboratory, Centre for Opportunistic, Tropical and Hospital Infections, National Institute for Communicable Diseases, Johannesburg, Sandringham, South Africa
    Parasit Vectors 6:229. 2013
    ..Pyrethroid resistance has been well documented in Anopheles arabiensis, one of the major African malaria vectors, and the predominant malaria vector in South Africa...
  20. ncbi Identification of a point mutation in the voltage-gated sodium channel gene of Kenyan Anopheles gambiae associated with resistance to DDT and pyrethroids
    H Ranson
    Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA
    Insect Mol Biol 9:491-7. 2000
    ..substitution at position 1014 of the voltage-gated sodium channel is associated with resistance to permethrin and DDT in many insect species, including Anopheles gambiae from West Africa...
  21. pmc Comparative molecular modeling of Anopheles gambiae CYP6Z1, a mosquito P450 capable of metabolizing DDT
    Ting Lan Chiu
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 105:8855-60. 2008
    ..the years developed resistance to insecticides including dieldrin, 1,1-bis(p-chlorophenyl)-2,2,2-trichloroethane (DDT), and pyrethroids. Previous microarray studies using fragments of 230 An...
  22. pmc A new classification system for the actions of IRS chemicals traditionally used for malaria control
    John P Grieco
    Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
    PLoS ONE 2:e716. 2007
    ..The laboratory tests showed the primary action of DDT is repellent, alphacypermethrin is irritant, and dieldrin is only toxic...
  23. pmc Genome-wide transcription profile of field- and laboratory-selected dichlorodiphenyltrichloroethane (DDT)-resistant Drosophila
    J H F Pedra
    Department of Entomology, Purdue University, West Lafayette, IN 47907 1158, USA
    Proc Natl Acad Sci U S A 101:7034-9. 2004
    ..only one gene, the cytochrome P450 enzyme Cyp6g1, is differentially transcribed in dichlorodiphenyltrichloroethane (DDT)-resistant vs...
  24. ncbi Anopheles arabiensis and An. quadriannulatus resistance to DDT in South Africa
    K Hargreaves
    Malaria Control Programme, KwaZulu Natal Department of Health, Jozini, South Africa
    Med Vet Entomol 17:417-22. 2003
    ..Western-type houses there are currently sprayed with deltamethrin, whereas traditional houses are sprayed with DDT for malaria control...
  25. ncbi The role of the Aedes aegypti Epsilon glutathione transferases in conferring resistance to DDT and pyrethroid insecticides
    Nongkran Lumjuan
    Research Institute for Health Sciences, Chiang Mai University, 110 Intavaroros Road, Chiang Mai, 50200, Thailand
    Insect Biochem Mol Biol 41:203-9. 2011
    ..291, which maps to chromosome 2. One Epsilon GST, GSTE2, has previously been implicated in conferring resistance to DDT. The amino acid sequence of GSTE2 in an insecticide susceptible and a DDT resistant strain differs at five residues ..
  26. ncbi Global surveillance of DDT and DDE levels in human tissues
    Kushik Jaga
    Montrose Research Corporation, VA Hudson Valley Health Care System, Montrose, New York, USA
    Int J Occup Med Environ Health 16:7-20. 2003
    The organochlorine insecticide dichlorodiphenyltrichloroethane (DDT) was initially introduced for control of vector-borne discases It was banned in the United States by the Environmental Protection Agency in 1972 because of potential ..
  27. pmc Ancestral dichlorodiphenyltrichloroethane (DDT) exposure promotes epigenetic transgenerational inheritance of obesity
    Michael K Skinner
    Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA 99164 4236, USA
    BMC Med 11:228. 2013
    ..The present work examined the potential transgenerational actions of the insecticide dichlorodiphenyltrichloroethane (DDT) on obesity and associated disease.
  28. pmc Evidence of carbamate resistance in urban populations of Anopheles gambiae s.s. mosquitoes resistant to DDT and deltamethrin insecticides in Lagos, South-Western Nigeria
    Adedayo O Oduola
    Molecular Entomology and Vector Control Research Laboratory, Public Health Division, Nigerian Institute of Medical Research, Akoka, Lagos, Nigeria
    Parasit Vectors 5:116. 2012
    ..was carried out to assess the susceptibility status of urban populations of Anopheles gambiae to carbamate insecticide being considered for vector control in mosquito populations previously reported to be resistant to DDT and permethrin.
  29. pmc Resistance to DDT and pyrethroids and increased kdr mutation frequency in An. gambiae after the implementation of permethrin-treated nets in Senegal
    Mamadou O Ndiath
    Institut de Recherche pour le Developpement, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes UMR 198, Campus commun UCAD IRD de Hann, BP 1386, CP 18524 Dakar, Senegal
    PLoS ONE 7:e31943. 2012
    ..gambiae mosquitoes sampled in Dielmo (Senegal), in 2010, 2 years after the implementation of Long Lasting Insecticide-treated Nets (LLINs) and to report the evolution of kdr mutation frequency from 2006 to 2010...
  30. ncbi Differential resistance of insect sodium channels with kdr mutations to deltamethrin, permethrin and DDT
    Mark J Burton
    School of Biology, University of Nottingham, University Park, Nottingham NG72RD, UK
    Insect Biochem Mol Biol 41:723-32. 2011
    ..Treatment of the wild-type channel with deltamethrin (≥ 1 nM), permethrin (≥ 30 nM) or DDT (≥ 1 μM) resulted in hyperpolarizing shifts in V(50,act)...
  31. ncbi Knockdown resistance to DDT and pyrethroids: from target-site mutations to molecular modelling
    Tg Emyr Davies
    Biological Chemistry Department, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK
    Pest Manag Sci 64:1126-30. 2008
    Naturally derived insecticides such as pyrethrum and man-made insecticides such as DDT and the synthetic pyrethroids act on the voltage-gated sodium channel proteins found in insect nerve-cell membranes...
  32. pmc Trends in DDT and pyrethroid resistance in Anopheles gambiae s.s. populations from urban and agro-industrial settings in southern Cameroon
    Philippe Nwane
    Organisation de Coordination pour la Lutte Contre les Endemies en Afrique Centrale, Yaounde, Cameroun
    BMC Infect Dis 9:163. 2009
    ..This study highlights trends in DDT and pyrethroid resistance in wild An. gambiae populations from South Cameroon.
  33. ncbi DDT resistance in flies carries no cost
    Caroline McCart
    Curr Biol 15:R587-9. 2005
  34. pmc Global status of DDT and its alternatives for use in vector control to prevent disease
    Henk van den Berg
    Laboratory of Entomology, Wageningen University, Wageningen, The Netherlands
    Environ Health Perspect 117:1656-63. 2009
    I review the status of dichlorodiphenyltrichloroethane (DDT), used for disease vector control, along with current evidence on its benefits and risks in relation to the available alternatives.
  35. pmc Spatio-temporal patterns in kdr frequency in permethrin and DDT resistant Anopheles gambiae s.s. from Uganda
    Katrijn Verhaeghen
    Department of Parasitology, Prince Leopold Institute of Tropical Medicine, Nationalestraat 155, B 2000 Antwerpen, Belgium
    Am J Trop Med Hyg 82:566-73. 2010
    ..Therefore, the pyrethroid and DDT resistance status of Anopheles gambiae s.l...
  36. pmc Control of pyrethroid and DDT-resistant Anopheles gambiae by application of indoor residual spraying or mosquito nets treated with a long-lasting organophosphate insecticide, chlorpyrifos-methyl
    Raphael N'Guessan
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Malar J 9:44. 2010
    ..The most cost-effective and longest-lasting residual insecticide DDT is also the most environmentally persistent...
  37. ncbi World-wide survey of an Accord insertion and its association with DDT resistance in Drosophila melanogaster
    F Catania
    Institut fur Tierzucht und Genetik, University of Wien, Josef Baumann Gasse 1, 1210 Wien, Austria
    Mol Ecol 13:2491-504. 2004
    ..This study confirms that hitchhiking mapping can be used to identify beneficial mutations in natural populations...
  38. pmc Maternal DDT exposures in relation to fetal and 5-year growth
    Todd A Jusko
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA
    Epidemiology 17:692-700. 2006
    Dichlorodiphenyltrichloroethane (DDT) is an organochlorine pesticide still used in areas of the world where malaria vector control is needed...
  39. ncbi Effects of chronic exposure to DDT and TCDD on disease activity in murine systemic lupus erythematosus
    J Li
    Department of Endocrinology and Metabolism, The First Affiliated Hospital, China Medical University, Shenyang, PR China
    Lupus 18:941-9. 2009
    ..This study examined the effects of chronic exposure to xenoestrogens -- o,p'-dichlorodiphenyltrichloroethane (DDT) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on disease activity in the New Zealand Black/New Zealand White F1 ..
  40. ncbi DDT reintroduction for malaria control: the cost-benefit debate for public health
    Raphael Mendonça Guimarães
    Instituto de Estudos em Saúde Coletiva, Universidade Federal do Rio de Janeiro, Avenida Brigadeiro Trompowski s n, Rio de Janeiro, Brazil
    Cad Saude Publica 23:2835-44. 2007
    b>DDT is a persistent insecticide that was widely used in the world from the 1940s until the 70s, when it was banned in the United States and other countries...
  41. ncbi Chlorfenapyr: a pyrrole insecticide for the control of pyrethroid or DDT resistant Anopheles gambiae (Diptera: Culicidae) mosquitoes
    P Boko
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Acta Trop 102:69-78. 2007
    ..Performance against An. gambiae bearing kdr (pyrethroid and DDT resistance) or Ace-1(R) insensitive acetylcholinesterase (organophosphate and carbamate resistance) mechanisms was ..
  42. ncbi Impregnated nets or ddt residual spraying? Field effectiveness of malaria prevention techniques in solomon islands, 1993-1999
    Mead Over
    Development Research Group, World Bank, Washington, District of Columbia 20433, USA
    Am J Trop Med Hyg 71:214-23. 2004
    ..The control program used a combination of methods including DDT residual house spraying and insecticide-treated mosquito nets...
  43. ncbi Characterisation of DDT, pyrethroid and carbamate resistance in Anopheles funestus from Obuasi, Ghana
    Patricia N Okoye
    Vector Control Reference Unit, National Institute for Communicable Diseases, National Health Laboratory Service NHLS, Sandringham, South Africa
    Trans R Soc Trop Med Hyg 102:591-8. 2008
    ..Samples of F1 progeny from each family were divided into cohorts and were either exposed to DDT and permethrin or were stored for biochemical analysis...
  44. ncbi Structure of an insect delta-class glutathione S-transferase from a DDT-resistant strain of the malaria vector Anopheles gambiae
    Liqing Chen
    Laboratory for Structural Biology, Department of Chemistry, Graduate Programs of Biotechnology, Chemistry and Materials Science, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    Acta Crystallogr D Biol Crystallogr 59:2211-7. 2003
    ..vector Anopheles gambiae, elevated GST levels are associated with resistance to the organochlorine insecticide DDT [1,1,1-trichloro-2,2-bis-(p-chlorophenyl)ethane]...
  45. ncbi Structure of an insect epsilon class glutathione S-transferase from the malaria vector Anopheles gambiae provides an explanation for the high DDT-detoxifying activity
    Yujun Wang
    Laboratory for Structural Biology, Department of Chemistry, Graduate Program of Biotechnology, University of Alabama in Huntsville, Huntsville, AL 35899, USA
    J Struct Biol 164:228-35. 2008
    ..gambiae, insect-specific epsilon class GSTs are associated with resistance to the organochlorine insecticide DDT [1,1,1-trichloro-2,2-bis-(p-chlorophenyl)ethane]...
  46. ncbi Pyrethroid, DDT and malathion resistance in the malaria vector Anopheles gambiae from the Democratic Republic of Congo
    Jean Pierre Basilua Kanza
    Institut Supérieur des Techniques Médicales de Kinshasa ISTM KIN, Laboratoire Spécial d Analyses Biomédicales, BP774 Kinshasa XI, Democratic Republic of Congo
    Trans R Soc Trop Med Hyg 107:8-14. 2013
    ..We investigated the extent of resistance in the malaria vector Anopheles gambiae from the Democratic Republic of Congo (DRC) to three classes of insecticide approved by WHO for indoor residual spraying...
  47. pmc Alternative treatments for indoor residual spraying for malaria control in a village with pyrethroid- and DDT-resistant vectors in the Gambia
    Julie Anne A Tangena
    Laboratory of Entomology, Wageningen University and Research Centre, EH Wageningen, Netherlands, Institut Pasteur du Laos, Vientiane, Lao PDR School of Biological and Biomedical Sciences, Durham University, Durham, United Kingdom
    PLoS ONE 8:e74351. 2013
    ..The second major vector control method is indoor residual spraying with pyrethroids or the organochloride DDT. However, resistance to pyrethroids frequently confers resistance to DDT...
  48. ncbi Glutathione S transferase activity in Indian vectors of malaria: A defense mechanism against DDT
    K Gunasekaran
    Division of Vector Biology and Control, Vector Control Research Centre Indian Council of Medical Research, Indira Nagar, Pondicherry 605 006, India
    J Med Entomol 48:561-9. 2011
    ..This investigation was to explore the metabolic status of GSTs in two Indian DDT-resistant malaria vectors, Anopheles culicifacies and Anopheles annularis, and one DDT-susceptible vector, ..
  49. ncbi Effects of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)-ethane (p,p'-DDT) on 3T3-L1 and 3T3-F442A adipocyte differentiation
    Maria J Moreno-Aliaga
    Department of Environmental Toxicology, Center for Environmental Health Sciences, University of California, Davis 95616, USA
    Biochem Pharmacol 63:997-1007. 2002
    Based upon our initial observations that 1,1,1-trichloro-2,2-bis(p-chlorophenyl)-ethane (p,p'-DDT) induces a concentration-dependent increase in 3T3-L1 adipocyte differentiation, the mechanism of the p,p'-DDT-induced adipocyte ..
  50. pmc Environmental organochlorine exposure as a potential etiologic factor in breast cancer
    M S Wolff
    Department of Community Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Environ Health Perspect 103:141-5. 1995
    ..The data are strongest for DDT. For PCBs, the results to date have been equivocal if not entirely negative...
  51. ncbi Xenobiotic-induced TNF-alpha expression and apoptosis through the p38 MAPK signaling pathway
    Daniel E Frigo
    Center for Bioenvironmental Research, Molecular and Cellular Biology Program, Tulane University Health Science Center, New Orleans, LA 70112, USA
    Toxicol Lett 155:227-38. 2005
    Some xenobiotics, such as dichlorodiphenyltrichloroethane (DDT), bind to and activate estrogen receptors (ERs), eliciting estrogenic effects in both wildlife and humans...
  52. ncbi Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding domains for pyrethroids and DDT
    P N R Usherwood
    School of Biology, The University of Nottingham, University Park, Nottingham, UK
    FEBS Lett 581:5485-92. 2007
    Mutations in the DIIS4-S5 linker and DIIS5 have identified hotspots of pyrethroid and DDT interaction with the Drosophila para sodium channel...
  53. ncbi Correcting serum concentrations of organochlorine compounds by lipids: alternatives to the organochlorine/total lipids ratio
    Miquel Porta
    Institut Municipal d Investigació Mèdica Hospital del Mar, E 08003 Barcelona, Catalonia, Spain
    Environ Int 35:1080-5. 2009
    ..Our aim was to analyze the relationship between serum OC and TL in patients with pancreatic ductal adenocarcinoma (PDA), and to explore several alternatives to perform the OC lipid correction...
  54. pmc Assaying organochlorines in archived serum for a large, long-term cohort: implications of combining assay results from multiple laboratories over time
    Robert I Sholtz
    Child Health and Development Studies, Public Health Institute, Berkeley, CA 94709, USA
    Environ Int 37:709-14. 2011
    ..We sought to determine whether we could successfully combine assay results for DDT-related compounds and polychlorinated biphenyls (PCBs) in serum from the same birth cohort obtained from different ..
  55. pmc Malaria control insecticide residues in breast milk: the need to consider infant health risks
    Hindrik Bouwman
    School of Environmental Sciences and Development Zoology, North West University, Potchefstroom, South Africa
    Environ Health Perspect 117:1477-80. 2009
    ..Except for dichlorodiphenyltrichloroethane (DDT), safety of residues of other insecticides in breast milk has not been considered during World Health Organization ..
  56. ncbi Comparative effects of permethrin-impregnated bednets and DDT house spraying on survival rates and oviposition interval of Anopheles farauti No. 1 (Diptera:Culicidae) in Solomon Islands
    J L Hii
    Department of Public Health and Tropical Medicine, James Cook University, Townsville, QLD, Australia
    Ann Trop Med Parasitol 89:521-9. 1995
    ..Houses in one of the villages were sprayed with DDT, another village was unsprayed but its inhabitants used permethrin-treated bednets and the third village was left ..
  57. ncbi DDT and urogenital malformations in newborn boys in a malarial area
    Riana Bornman
    Department of Urology, University of Pretoria, Pretoria, South Africa
    BJU Int 106:405-11. 2010
    ..newborn boys from a malarial area currently sprayed with technical 1,1,1-trichloro-2,2-bis(4-chlorophenyl) ethane (DDT), as increased fetal oestrogenic or anti-androgenic exposure might be involved in the pathogenesis of increased ..
  58. ncbi Point mutations associated with insecticide resistance in the Drosophila cytochrome P450 Cyp6a2 enable DDT metabolism
    Marcel Amichot
    Unité Mixte de Recherche 1112, Institut National de la Recherche Agronomique, Sophia Antipolis, France
    Eur J Biochem 271:1250-7. 2004
    ..of a cytochrome P450 CYP6A2 variant assumed to be responsible for 1,1,1-trichloro-2,2-bis-(4'-chlorophenyl)ethane (DDT) resistance in the RDDT(R) strain of Drosophila melanogaster...
  59. pmc Distribution of knock-down resistance mutations in Anopheles gambiae molecular forms in west and west-central Africa
    Federica Santolamazza
    Istituto Pasteur Fondazione Cenci Bolognetti, Universita La Sapienza, Rome, Italy
    Malar J 7:74. 2008
    Knock-down resistance (kdr) to DDT and pyrethroids in the major Afrotropical vector species, Anopheles gambiae sensu stricto, is associated with two alternative point mutations at amino acid position 1014 of the voltage-gated sodium ..
  60. ncbi DDT resistance in Drosophila correlates with Cyp6g1 over-expression and confers cross-resistance to the neonicotinoid imidacloprid
    P Daborn
    Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
    Mol Genet Genomics 266:556-63. 2001
    ..By recombinational mapping we show that these map to the same location as Rst(2)DDT. Furthermore, we show that pre-existing Rst(2)DDT alleles in turn confer cross-resistance to imidacloprid...
  61. ncbi Distribution of pyrethroid and DDT resistance and the L1014F kdr mutation in Anopheles gambiae s.l. from Burkina Faso (West Africa)
    K R Dabire
    Insitut de Recherche en Science de la Santé IRSS Centre Muraz, BP 390, Bobo Dioulasso, Burkina Faso
    Trans R Soc Trop Med Hyg 103:1113-20. 2009
    This study reports on the distribution of pyrethroid and DDT resistance and the L1014F knockdown resistance (kdr) mutation in Anopheles gambiae s.l...
  62. ncbi Insecticide resistance in the malarial mosquito Anopheles arabiensis and association with the kdr mutation
    T S Matambo
    Vector Control Reference Unit, National Institute for Communicable Diseases, NHLS, Sandringham, Johannesburg, South Africa
    Med Vet Entomol 21:97-102. 2007
    ..Culicidae) from the Sennar region of Sudan was selected for resistance to dichlorodiphenyltrichloroethane (DDT)...
  63. pmc Body burdens of brominated flame retardants and other persistent organo-halogenated compounds and their descriptors in US girls
    Gayle C Windham
    CA Department of Public Health, DEODC, 850 Marina Bay Pkwy, Bldg P, Richmond, CA 94804, USA
    Environ Res 110:251-7. 2010
    ..Exposures to such chemicals may affect a number of health outcomes related to development and reproductive function...
  64. pmc Commentary: malaria control in the 1990s
    P I Trigg
    Division of Control of Tropical Diseases, World Health Organization, Geneva, Switzerland
    Bull World Health Organ 76:11-6. 1998
    ..1955 the Eighth World Health Assembly adopted a Global Malaria Eradication Campaign based on the widespread use of DDT against mosquitos and of antimalarial drugs to treat malaria and to eliminate the parasite in humans...
  65. pmc DDT and breast cancer in young women: new data on the significance of age at exposure
    Barbara A Cohn
    Child Health and Development Studies, Center for Research on Women s and Children s Health, Public Health Institute, Berkeley, California 94709, USA
    Environ Health Perspect 115:1406-14. 2007
    Previous studies of DDT and breast cancer assessed exposure later in life when the breast may not have been vulnerable, after most DDT had been eliminated, and after DDT had been banned.
  66. ncbi Effect of polychlorinated biphenyls (PCBs) and 1,1,1-trichloro-2,2,-bis (4-chlorophenyl)-ethane (DDT) in follicular fluid on the results of in vitro fertilization-embryo transfer (IVF-ET) programs
    Simona Jirsová
    Department of Gynecology and Obstetrics, Charles University, First Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic
    Fertil Steril 93:1831-6. 2010
    ..To establish the effect of chlorinated organic compounds on fertility...
  67. pmc Developmental and environmental origins of breast cancer: DDT as a case study
    Barbara A Cohn
    Child Health and Development Studies, The Public Health Institute, Berkeley, CA 94709, United States
    Reprod Toxicol 31:302-11. 2011
    More than 20 studies of serum "DDT" and breast cancer have found little support for the hypothesis that exposure influences risk of breast cancer...
  68. ncbi Estrogens and environmental estrogens
    H Tapiero
    Laboratoire de Pharmacologie Cellulaire and Moléculaire, CNRS UMR 8612, Universite de Paris Sud, Faculte de Pharmacie, Chatenay Malabry, France
    Biomed Pharmacother 56:36-44. 2002
    ..environmental estrogens such as beta-hexachlorocyclohexane (beta-HCH), polychlorinated biphenyls (PCBs), o, p, p'DDT, 4-nonylphenol (NP) and phytoestrogens such as isoflavones or lignans, are more stable and remain in the body ..
  69. pmc Fungal infection counters insecticide resistance in African malaria mosquitoes
    Marit Farenhorst
    Laboratory of Entomology, Wageningen University and Research Centre, P O Box 8031, 6700 EH Wageningen, The Netherlands
    Proc Natl Acad Sci U S A 106:17443-7. 2009
    ..Our results show a high potential utility of fungal biopesticides for complementing existing vector control measures and provide products for use in resistance management strategies...
  70. ncbi Expression of Cyp6g1 and Cyp12d1 in DDT resistant and susceptible strains of Drosophila melanogaster
    R A Festucci-Buselli
    Department of Entomology, Purdue University, 1158 Smith Hall, West Lafayette, IN 47907 1158, USA
    Insect Mol Biol 14:69-77. 2005
    The Rst(2)DDT locus (loci) in Drosophila is associated with the over-expression of two cytochrome P450 genes, Cyp6g1 and Cyp12d1...
  71. ncbi kdr: can a single mutation produce an entire insecticide resistance phenotype?
    Basil D Brooke
    Vector Control Reference Unit, National Institute for Communicable Diseases, NHLS, Sandringham, South Africa
    Trans R Soc Trop Med Hyg 102:524-5. 2008
    Knockdown resistance (kdr) is closely associated with DDT and pyrethroid resistance in the major malaria vector Anopheles gambiae and is considered to be causative of the resistance phenotype...
  72. ncbi Metabolism of imidacloprid and DDT by P450 CYP6G1 expressed in cell cultures of Nicotiana tabacum suggests detoxification of these insecticides in Cyp6g1-overexpressing strains of Drosophila melanogaster, leading to resistance
    Nicole Joussen
    Institute of Biology V, RWTH Aachen University, Worringerweg 1, D 52056 Aachen, Germany
    Pest Manag Sci 64:65-73. 2008
    ..melanogaster are resistant to a wide range of chemically diverse insecticides, including DDT and imidacloprid...
  73. ncbi Contribution of sociodemographic characteristics, occupation, diet and lifestyle to DDT and DDE concentrations in serum and adipose tissue from a Bolivian cohort
    J P Arrebola
    Laboratory of Medical Investigations, San Cecilio University Hospital, University of Granada, Spain
    Environ Int 38:54-61. 2012
    The organochlorine pesticide p,p'-Dichlorodiphenyltrichloroethane (DDT) was widely used in the early 1960s-70s for vector control in tropical and subtropical areas of South America...
  74. pmc The effect of larval nutritional deprivation on the life history and DDT resistance phenotype in laboratory strains of the malaria vector Anopheles arabiensis
    Shüne V Oliver
    National Institute for Communicable Disease, Sandringham, Johannesburg, South Africa
    Malar J 12:44. 2013
    ..The aim of this study was to examine the effect of larval nutrition on the life history and expression of insecticide resistance in adults of laboratory reared An. arabiensis...
  75. ncbi Differential expression and induction of two Drosophila cytochrome P450 genes near the Rst(2)DDT locus
    A Brandt
    Department of Entomology, Room 100, 1158 Smith Hall, Purdue University, West Lafayette, IN 47907 1158, USA
    Insect Mol Biol 11:337-41. 2002
    ..studies have shown that the major metabolic resistance locus in the insecticide-resistant Drosophila line Rst(2)DDT(Wisconsin) maps between the markers cn and vg on chromosome 2. Six cytochrome P450 genes exist in this region...
  76. ncbi Factors affecting organochlorine contaminant concentrations in milk and blood of northern fur seal (Callorhinus ursinus) dams and pups from St. George Island, Alaska
    K B Beckmen
    Institute of Arctic Biology, University of Alaska Fairbanks 99775 7000, USA
    Sci Total Environ 231:183-200. 1999
    ..The contaminants included 15 selected individual polychlorinated biphenyl (PCB) congeners and DDT metabolites identified through high-performance liquid chromatography...
  77. ncbi Behavioral responses to DDT and pyrethroids between Anopheles minimus species A and C, malaria vectors in Thailand
    Jinnapa Potikasikorn
    Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok, Thailand
    Am J Trop Med Hyg 73:343-9. 2005
    ..and non-contact actions of chemicals were compared during and after exposure to operational field concentrations of DDT (2 g/m2), deltamethrin (0.02 g/m2), and lambdacyhalothrin (0.03 g/m2) using an excito-repellency escape chamber...
  78. pmc The Pine River statement: human health consequences of DDT use
    Brenda Eskenazi
    School of Public Health, University of California Berkeley, 2150 Shattuck Avenue, Berkeley, CA 94720, USA
    Environ Health Perspect 117:1359-67. 2009
    Dichlorodiphenyltrichloroethane (DDT) was used worldwide until the 1970s, when concerns about its toxic effects, its environmental persistence, and its concentration in the food supply led to use restrictions and prohibitions...
  79. pmc Malaria control and public health
    Donald Roberts
    Emerg Infect Dis 10:1170-1; author reply 1171-2. 2004
  80. ncbi High levels of DDT in breast milk: intake, risk, lactation duration, and involvement of gender
    Hindrik Bouwman
    School of Environmental Sciences and Development, North West University, Potchefstroom 2520, South Africa
    Environ Pollut 170:63-70. 2012
    We investigated presence and levels of DDT in 163 breast milk samples from four South African villages where, in three of them, malaria is controlled with DDT-sprayed indoors. Mean ΣDDT levels in breast milk were 18, 11, and 9...
  81. ncbi Three second chromosome-linked clustered Cyp6 genes show differential constitutive and barbital-induced expression in DDT-resistant and susceptible strains of Drosophila melanogaster
    S Maitra
    Department of Biochemistry and Cell and Molecular Biology, University of Tennessee, Knoxville 37996, USA
    Gene 180:165-71. 1996
    The level of expression of the Cyp6a2 gene is much higher in the DDT-resistant 91-R strain than in the susceptible 91-C strain of Drosophila melanogaster (Waters et al. (1992b) Proc. Natl. Acad. Sci. USA, 89, 4855-4859)...
  82. pmc Endocrine disruptor regulation of microRNA expression in breast carcinoma cells
    Syreeta L Tilghman
    Division of Basic Pharmaceutical Sciences, College of Pharmacy, Xavier University of Louisiana, New Orleans, Louisiana, United States of America
    PLoS ONE 7:e32754. 2012
    ..The EDCs DDT and BPA are ubiquitously present in the environment, and DDT and BPA levels in human blood and adipose tissue are ..
  83. ncbi Extension of indoor residual spraying for malaria control into high transmission settings in Africa
    Kate Kolaczinski
    Malaria Consortium Africa, P O Box 8045, Sturrock Road, Kampala, Uganda
    Trans R Soc Trop Med Hyg 101:852-3. 2007
    ..spraying (IRS) in malaria control in high transmission settings of sub-Saharan Africa and re-emphasises the role of DDT. We review the issues related to this change in recommendation...
  84. pmc Prenatal exposure to the major DDT metabolite 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and growth in boys from Mexico
    Lea A Cupul-Uicab
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 TW Alexander Dr, Research Triangle Park, NC 27709, USA
    Environ Res 110:595-603. 2010
    ..between prenatal DDE exposure and growth was evaluated in 788 boys from Chiapas, an area of Mexico where DDT was recently used. The median DDE levels in maternal serum at birth (2002-2003) were 2.7 microg/g lipid...
  85. pmc Extensive permethrin and DDT resistance in Anopheles arabiensis from eastern and central Sudan
    Yousif E Himeidan
    Entomology Unit, Faculty of Agriculture and Natural Resources, University of Kassala, New Halfa, Sudan
    Parasit Vectors 4:154. 2011
    ..This study assessed resistance to permethrin and DDT in seven populations of Anopheles arabiensis from Sudan.
  86. ncbi Organochlorine pesticides in the surface water and sediments from the Peacock River Drainage Basin in Xinjiang, China: a study of an arid zone in Central Asia
    Wei Chen
    Key Laboratory of Biogeology and Environmental Geology of the Ministry of Education, Wuhan 430074, People s Republic of China
    Environ Monit Assess 177:1-21. 2011
    ..All the analyzed organochlorine pesticides, except o,p'-DDT, were detected in sediments from the Peacock River; but in the water samples, only β-HCH, HCB, p,p'-DDD, and p,p'-..
  87. ncbi Occurrence and distribution of organochlorine pesticides (HCH and DDT) in sediments collected from East China Sea
    Rui qiang Yang
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
    Environ Int 31:799-804. 2005
    ..The levels and distribution patterns of the selected organochlorine pesticides (OCPs=p,p'-DDT, o,p'-DDT, p,p'-DDE, p,p'-DDD, alpha-, beta-, gamma- and delta-HCH) in samples were investigated by the technique ..
  88. ncbi Should DDT be banned by international treaty?
    C F Curtis
    London School of Hygiene and Tropical Medicine, Keppel Street, London, UK WC1E 7HT
    Parasitol Today 16:119-21. 2000
    The insecticide DDT has been an effective and affordable means of malaria control in many countries, but pressure for its use to be banned is mounting...
  89. ncbi Relation of DDT residues to plasma retinol, alpha-tocopherol, and beta-carotene during pregnancy and malaria infection: a case-control study in Karen women in northern Thailand
    W Stuetz
    Institute of Biological Chemistry and Nutrition, University of Hohenheim, 70599 Stuttgart, Germany
    Sci Total Environ 363:78-86. 2006
    Populations living in endemic malaria areas maybe exposed simultaneously to DDT and malaria infection. DDT may impair status of vitamins, which are implicated in the immunity and pathophysiology of malaria...
  90. ncbi Insecticide susceptibility level of Anopheles arabiensis in two agrodevelopment localities in eastern Ethiopia
    M Balkew
    Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia
    Parassitologia 45:1-3. 2003
    ..The insecticides used were WHO discriminating doses of 4% DDT, 0.75% permethrin and 0.1% propoxur. The study revealed that 42.5% of the An...
  91. ncbi Susceptibility of Anopheles gambiae s.l. to DDT, malathion, permethrin and deltamethrin in Ethiopia
    Alemayehu Abate
    Ethiopian Health and Nutrition Research Institute, Addis Ababa, Ethiopia
    Trop Med Int Health 16:486-91. 2011
    To assess the susceptibility/resistance level of Anopheles gambiae s.l. to DDT, malathion, permethrin and deltamethrin in different parts of Ethiopia.
  92. ncbi Inadvertent exposure to organochlorine pesticides DDT and derivatives in people from the Canary Islands (Spain)
    Manuel Zumbado
    Toxicology Unit, Department of Clinical Sciences, University of Las Palmas de Gran Canaria, P O Box 550, 35080, Las Palmas de Gran Canaria, Spain
    Sci Total Environ 339:49-62. 2005
    ..farming areas have been developed in these last decades, with greenhouses dedicated to intensive cultivation using DDT in huge amounts. In Spain, similarly to other European countries, DDT was banned in the late 1970s...
  93. ncbi The role of cyclooxygenase-2-dependent signaling via cyclic AMP response element activation on aromatase up-regulation by o,p'-DDT in human breast cancer cells
    Eun Hee Han
    Department of Toxicology, College of Pharmacy, Chungnam National University, 220 Gung Dong, Daejeon 305 764, Yuseong Gu, South Korea
    Toxicol Lett 198:331-41. 2010
    o,p'-Dichlorodiphenyltrichloroethane (o,p'-DDT) is a DDT isomer and xenoestrogen that can induce inflammation and cancer. However, the effect of o,p'-DDT on aromatase is unclear...
  94. ncbi Mercury and DDT exposure risk to fish-eating human populations in Amazon
    Inês da Silva Rabitto
    Departamento de Biologia Celular, Setor de Ciencias Biologicas, Universidade Federal do Parana, Curitiba, Parana, Brazil
    Environ Int 37:56-65. 2011
    ..For total mercury, DDT and DDE quantifications and cholinesterase activity samples of the axial muscle were frozen at -20°C, and for ..
  95. ncbi Susceptibility of sand flies to selected insecticides in North Africa and the Middle East
    G E Tetreault
    Vector Biology Research Program, US Naval Medical Research Unit Number Three, AE 09835, USA
    J Am Mosq Control Assoc 17:23-7. 2001
    ..Fifty, 90, and 99% lethal doses were calculated for bendiocarb, cyfluthrin, DDT, malathion, permethrin, and resmethrin on Phlebotomus bergeroti, P. langeroni, P. papatasi. and P. sergenti...
  96. ncbi (-)-Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, reduces dichlorodiphenyl-trichloroethane (DDT)-induced cell death in dopaminergic SHSY-5Y cells
    Kwok Keung Tai
    The Parkinson s and Movement Disorder Research Laboratory, Long Beach Memorial Medical Center, 2801 Atlantic Ave, Long Beach, CA 90806, USA
    Neurosci Lett 482:183-7. 2010
    ..polyphenol, concentration-dependently (1 microM, 3 microM and 10 microM) reduced dichlorodiphenyl-trichloroethane (DDT) (100 microM)-induced cell death in dopaminergic neuroblastoma SHSY-5Y cells...
  97. ncbi Concentration of selected persistent organic pollutants in blood from delivering women in South Africa
    H B Rollin
    South African Medical Research Council, PO Box 87373, Houghton 2041, Johannesburg, South Africa
    Sci Total Environ 408:146-52. 2009
    ..28, 52, 99, 101, 105, 118, 138, 149, 153, 156, 170, 180, 183, 187, 194); six DDT metabolites (dichlordiphenyltrichloroethane p,p'-DDT and o,p'-DDT; diphenyldichloroethylene p,p'-DDE and o,p'-DDE, ..
  98. ncbi Synergistic genotoxicity caused by low concentration of titanium dioxide nanoparticles and p,p'-DDT in human hepatocytes
    Yun Shi
    MOE Key Laboratory of Environment and Health, Institute of Environmental Medicine, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
    Environ Mol Mutagen 51:192-204. 2010
    The use of titanium dioxide nanoparticles (nano-TiO(2)) for the degradation of dichlorodiphenyltrichloroethane (p,p'-DDT) increases the risk of exposure to trace nano-TiO(2) and p,p'-DDT mixtures...
  99. pmc Organochlorine-mediated potentiation of the general coactivator p300 through p38 mitogen-activated protein kinase
    Melyssa R Bratton
    Department of Pharmacology, Tulane University Health Science Center, New Orleans, LA 70112, USA
    Carcinogenesis 30:106-13. 2009
    ..We have previously shown that the organochlorine pesticide dichlorodiphenyltrichloroethane (DDT) stimulates activator protein-1 activity through the p38 mitogen-activated protein kinase (MAPK)...
  100. ncbi Recognition and detoxification of the insecticide DDT by Drosophila melanogaster glutathione S-transferase D1
    Wai Yee Low
    Department of Genetics, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Melbourne, Victoria 3010, Australia
    J Mol Biol 399:358-66. 2010
    GSTD1 is one of several insect glutathione S-transferases capable of metabolizing the insecticide DDT. Here we use crystallography and NMR to elucidate the binding of DDT and glutathione to GSTD1...
  101. pmc Characterization of the de novo biosynthetic enzyme of platelet activating factor, DDT-insensitive cholinephosphotransferase, of human mesangial cells
    Alexandros Basilios Tsoupras
    Faculty of Chemistry, School of Sciences, National and Kapodistrian University of Athens, Panepistimioupolis, 15771 Athens, Greece
    Mediators Inflamm 2007:27683. 2007
    ..The results indicated that the above compounds can influence PAF-CPT activity of HMC...

Research Grants63

  1. Organochlorine pesticide, PCBs, and Parkinsons
    Alberto Ascherio; Fiscal Year: 2007
    ..1) That higher plasma levels of para, para-dichlorodiphenyl dichloroethene [p,p-DDE], the major metabolite of DDT, dieldrin, hexachlorobenzene (HCB), beta-hexachlorocyclohexane (HCH), heptachlor, heptachlor epoxide, trans-..
  2. NIEHS SUPPORT OF THE AHS COHORT STUDY AT NCI
    Charles Knott; Fiscal Year: 2010
    ..studies of non-Hodgkin's lymphoma noted an association with agricultural use of lindane, but not with DDT. Another case-control study indicated that chemotherapy for non-Hodgkin's Lymphoma affects blood levels of ..
  3. THE AGRICULTURAL HEALTH STUDY - FIELD STATIONS
    Charles Lynch; Fiscal Year: 2010
    ..studies of non-Hodgkin's lymphoma noted an association with agricultural use of lindane, but not with DDT. Another case-control study indicated that chemotherapy for non-Hodgkin's Lymphoma affects blood levels of ..
  4. Preconception Nutrition, Endocrine Disruptors, Reproductive Outcomes
    Xiaobin Wang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Dichlorodiphenyl trichloroethane (DDT) and its metabolites including dichlorodiphenyl dichloroethene (DDE) are known endocrine disruptors...
  5. Environmental Endocrine Disruptors and Human Sperm Chromosomal Abnormalities
    Melissa Perry; Fiscal Year: 2012
    ..between sperm aneuploidy and common environmental exposures, specifically polychlorinated biphenyls (PCBs), DDT, organophosphates (OPs), and pyrethroids (PYRs)...
  6. IRS insecticides for malaria control and child neurodevelopment in South Africa
    Brenda Eskenazi; Fiscal Year: 2013
    ..malaria-endemic countries use Indoor Residual Spraying (IRS), the application of dichlorodiphenyl trichloroethane (DDT) or pyrethroid insecticides to interior walls of homes, to control malaria...
  7. Perinatal Exposure to Environmental DDT and Risk of Metabolic Syndrome
    Michele La Merrill; Fiscal Year: 2012
    ..epidemiology and enable her to advance her scientific career by investigating the possible contribution of DDT exposure in early life to risk of the metabolic syndrome and diabetes...
  8. Organochlorine and Gene Expression of Sex Steroids in a Multigenerational Cohort
    Janet Rose Osuch; Fiscal Year: 2011
    ..in F1 generation females, depending on estimated levels of in-utero exposure to maternal blood levels of PCBs and DDT. The proposed analysis will consist of age-appropriate telephone interviews to ascertain a medical history, an ..
  9. Development of a Field Applicable Screening Tool (FAST) kit for detecting resista
    MARTIN JAMES DONNELLY; Fiscal Year: 2013
    ..insecticides that are used for indoor residual spraying (IRS) for malaria and filariasis namely an organochloride (DDT), a carbamate (Bendiocarb) and a class II pyrethroid (?-cyhalothrin)...
  10. Regulation of the DNA damage Response
    Karlene A Cimprich; Fiscal Year: 2013
    ..Cells employ DNA damage tolerance (DDT) pathways to ensure the completion of DNA replication by filling in gaps created by replication barriers or lesions ..
  11. Perinatal Exposure to Environmental DDT and Risk of Metabolic Syndrome
    Michele La Merrill; Fiscal Year: 2013
    ..epidemiology and enable her to advance her scientific career by investigating the possible contribution of DDT exposure in early life to risk of the metabolic syndrome and diabetes...
  12. Mechanisms of Rheumatoid Synovial Fibroblast Activation
    RICHARD J BUCALA; Fiscal Year: 2013
    ..differences between MIF and MIF receptor deficient mice, we discovered a new MIF-like cytokine encoded by the Ddt locus...
  13. Diabetes and Persistent Organic Pollutants
    MARY ELLEN TURYK; Fiscal Year: 2010
    ..polybrominated biphenyl ethers (PBDEs), and p,p'-diphenyldichloroethene (DDE), a metabolite of the pesticide DDT (dichlorodiphenyltrichloroethane)...
  14. DDT &PBDE exposure, puberty onset and neurodevelopment in Mexican-American girls
    Brenda Eskenazi; Fiscal Year: 2013
    ..An exception was made for use of dichlorodiphenylthrichloroethane (DDT) for malaria control, and this use is increasing in many developing countries...
  15. Center for Children's Environmental Health Research
    Brenda Eskenazi; Fiscal Year: 2013
    ..We will expand our focus to a "California mix" of chemicals: dichlorodiphenyltrichloroethane (DDT), which the children were exposed to in utero due to their mothers'exposure in Mexico;manganese (Mn), wtiich ..
  16. Sub Clinical Cardiovascular Disease in Youth (SEARCH CVD)
    Dana Dabelea; Fiscal Year: 2010
    ..The proposed work is an ancillary study to the CDC/DDT and NIH/NIDDK funded SEARCH for Diabetes in Youth project, The current proposal (SEARCH CVD) will integrate all ..
  17. Modulators of maladaptive decision-making in methamphetamine dependence
    Milky Kohno; Fiscal Year: 2013
    ..Responses during decision-making under risk, reward or delay will be examined using the Delay Discounting Task (DDT) (10) and the Balloon Analog Risk Task (BART) (11)...
  18. Communicating about Choices in Transplantation: An Educational Intervention
    HEATHER MARIE MARSHALL TRAINO; Fiscal Year: 2013
    ..As compared to sustained dialysis or deceased donor transplantation (DDT), live donor transplantation (LDT) is associated with better patient and graft survival...
  19. Pilot-scale Research of Novel Amendment Delivery for in-situ Sediment Remediation
    Upal Ghosh; Fiscal Year: 2009
    ..This field research project will be carried out at two PCB/DDT-impacted sensitive wetland sites...
  20. Development of Stable Isotope Based Methods to Predict Bioavailability of Hydroph
    Jay Gan; Fiscal Year: 2013
    ..bioavailability is a key to better assessing human exposure to hydrophobic organic contaminants (HOCs) such as DDT, PCBs, PAHs and dioxins through consumption of fish from contaminated areas...
  21. LIGNIN BIODEGRADATON--LIGNINASE & GLUCOSE OXIDASE GENES
    CA REDDY; Fiscal Year: 1992
    ..of lignin, also play a key role in the detoxification of recalcitrant environmental pollutants such as dioxins, DDT, lindane and benzopyrenes, which constitute a serious public health hazard...
  22. Border Environmental Health &Toxicology Educational Research Program
    Thomas J McDonald; Fiscal Year: 2011
    ..near Laredo and communities adjacent to Kelly Air Force Base in San Antonio;(4) monitor biomarkers of exposure to DDT and other chlorinated pesticides in families living in rural colonias near Laredo and communities adjacent to Kelly ..
  23. Effects of Environmental Estrogen Exposure on Spontaneous Copy Number Variation
    Kim H Brown; Fiscal Year: 2011
    ..These chemicals include a broad array of compounds from pesticides such as DDT, plasticizers such as Bisphenol A and pharmaceuticals such as human birth control pills (17-alpha-ethynylestradiol;..
  24. Maternal Pesticide Exposure and Pregnancy Outcomes
    Russ Hauser; Fiscal Year: 2009
    Although the use of polychlorinated biphenyls (PCBs) and many of the chlorinated pesticides, including DDT, are now prohibited or restricted, there remains concern over their potential human health effects because they persist in the ..
  25. Effects of Environmental Estrogen Exposure on Spontaneous Copy Number Variation
    Kim H Brown; Fiscal Year: 2013
    ..These chemicals include a broad array of compounds from pesticides such as DDT, plasticizers such as bisphenol A and pharmaceuticals such as human birth control pills (17[unreadable]-..
  26. COMPARISON OF RAT & TROUT HEPATIC P450 INDUCTION
    JOHN LECH; Fiscal Year: 1993
    ..g. other barbiturates, PCBs with ortho chlorines, DDT, phenytoin, 5,5- diphenylhydantoin) hepatic cytochrome P450 inducers control gene expression by using a responsive (..
  27. Xenobiotics and Breast Epithelial Cell-ECM Signaling
    Raymond Novak; Fiscal Year: 2005
    ..Treatment of cells with p,p'-DDT results in increased delta-catenin levels relative to controls, whereas Kepone decreases alpha-catenin expression 2-..
  28. DDT, Endocrine Disruption and Reproductive Outcomes
    Xiaobin Wang; Fiscal Year: 2003
    ..Both animal and in vitro studies support the hypothesis that dichlorodiphenyl trichloroethane (DDT) and its metabolites are potentially important human reproductive toxins...
  29. Insecticide resistance in Africa Malaria mosquitoes
    Maureen Coetzee; Fiscal Year: 2004
    ..Compounding factors include the following. 1) Mozambique will not allow the use of DDT for house spraying and therefore will not achieve 100% eradication of the vector species An...
  30. ORGANOCHLORINE COMPOUNDS AND RISK OF BREAST CANCER
    Tongzhang Zheng; Fiscal Year: 1993
    ..biphenyls (PCBs) and specific major PCB congeners increases the risk of female breast cancer; b) exposure to DDT and its most stable and persistent metabolite DDE increases the risk of female breast cancer; and c) exposure to ..
  31. ORGANOCHLORINES AND METALS IN NEW YORK AND THE HUDSON
    Philip Landrigan; Fiscal Year: 2006
    ..densely populated, heavily industrialized region that is contaminated by a complex mix of organochlorines - PCBs, DDT, chlordane, dieldrin, and dioxins - as well as by heavy metals, especially lead and mercury...
  32. Extreme Ammonia Tolerance Mechanisms: A Model Vertebrate
    Patrick Walsh; Fiscal Year: 2004
    ..In particular, liver damage due to exposure to toxicants such as carbon tetrachloride, toluene, DDT, heptachlor, etc...
  33. MOLECULAR MECHANISM OF IMMUNOTOXIC ACTION OF TCDD & DDT
    Fusao Hirata; Fiscal Year: 1993
    ....
  34. A New Nano Based Real-Time Mycotoxin Detector
    NICHOLAS SMILANICH; Fiscal Year: 2007
    ..The substance is so toxic that it is one of 19 contaminants-along with mercury and DDT-for which the U.S...
  35. ORGANOCHLORINE COMPOUNDS AND MENSTRUAL CYCLE FUNCTION
    Gayle Windham; Fiscal Year: 1999
    ..Exposure will be measured by determining levels of DDT and other pesticide metabolites in a serum sample...
  36. ORGANOCHLORINE PESTICIDES AND MALE GENITAL ANOMALIES
    Rajiv Bhatia; Fiscal Year: 2002
    b>DDT, one of the most ubiquitous of a class of endocrine disrupting chemicals, has been associated with dramatic adverse effects on the reproductive systems of animals...
  37. ALPHA 1-ADRENERGIC RECEPTORS & SMOOTH MUSCLE RESPONSES
    Robert Brown; Fiscal Year: 1992
    ..The receptor will be detergent solubilized from DDT-1 smooth muscle cells and purified using derivatives of the antagonist prazosin as ligands for affinity ..
  38. Metabolomic Assessment of Estrogenic Endocrine Disruptor
    Timothy Zacharewski; Fiscal Year: 2009
    ..The comparative effects of ethynyl estradiol (EE), genistein (GEN), and o, p'-dichlorodiphenyltrichloroethane (DDT) on metabolite levels will be assessed in urine, serum and liver extracts by multinuclear (i. e...
  39. GENES AND CHEMICAL EXPOSURE ASSOCIATED WITH SLE RISK
    Patricia Fraser; Fiscal Year: 2001
    ..variety of mechanisms, organochlorines in the environment such as 2,2-bis(rho-chlorophenyl)-1,1,1- trichlorethane (DDT), and its long-lasting metabolite DDE may affect sex hormone homeostasis...
  40. Molecular genetics of metabolic pesticide resistance
    Barry Pittendrigh; Fiscal Year: 2004
    ..The major metabolic resistance locus in Drosophila is a dominant trait known as Rst (2) DDT. This locus has been mapped to a region encompassing 35 previously sequenced genes, but to date we do not know ..
  41. REGIONAL VARIATION OF BREAST CANCER RATES IN WISCONSIN
    Patrick Remington; Fiscal Year: 2002
    ..variations in breast cancer rates; and 3) evaluating the association between environmental exposures (such as PCBs, DDT, and other xenoestrogens) and breast cancer risk, and if associated, the contribution of these exposures to the ..
  42. ENVIRONMENTAL AND GENETIC DETERMINANTS OF BREAST CANCER
    Mary Wolff; Fiscal Year: 1993
    ..has found a powerful association between female breast cancer and body burden of DDE, the principal metabolite of DDT. This association is stronger (RR equals approximately 4) than that between breast cancer and obesity (RR less than ..
  43. ABNORMAL MOVEMENTS AND PHARMACOLOGY OF THE FOREBRAIN
    S Snodgrass; Fiscal Year: 1980
    ..other benzodiazepines on myoclonics after raphe lsions, using both 5-HTP induced myoclonus and that produced by o,p-DDT. We are also studying the recovery of function which occurs after selective lesions of the median raphe nucleus...
  44. ENVIRONMENTAL POLLUTANTS AND MEMBRANE TRANSPORT
    David Miller; Fiscal Year: 1980
    ..The objective of this project is to identify DDT and heavy metal sensitive sites in bird and fish epithelia using these powerful new procedures to complement ..
  45. Exposure to Organochlorines, EBV, and the Risk of NHL
    Francine Laden; Fiscal Year: 2006
    ..evidence suggests a role in the etiology of the disease for organochlorine compounds, such as the pesticide DDT and the industrial chemicals polychlorinated biphenyls (PCBs) and for the Epstein-Barr Virus (EBV)...
  46. ENVIRONMENTAL TOXINS AND ESTABLISHMENT OF PREGNANCY
    Donald Johnson; Fiscal Year: 1993
    ..growth factor-I (IGF-I) messenger RNAs and proteins in the uteri of rats exposed to each of three toxins O- P'-DDT, Methoxychlor, and Chlordecone...
  47. MECHANISM OF ESTROGENICITY OF DDT ANALOGS IN MCG-7 CELLS
    Fumio Matsumura; Fiscal Year: 2001
    ..In our preliminary studies we have clearly established in a human breast carcinoma cell line, MCF-7, that o,p'-DDT and beta-HCH at very low doses cause a rise in c-Neu (= c-erbB2) protein tyrosine kinase activity...
  48. BREAST CANCER AND THE ENVIRONMENT ON LONG ISLAND
    Marilie Gammon; Fiscal Year: 2004
    ..developing breast cancer is increased among women with higher levels of serum organochlorine compounds, including DDT and PCBs, or higher levels of polycyclic aromatic hydrocarbons, assessed by PAH-DNA levels in blood samples...
  49. EFFECTS OF PESTICIDE METHOXYCHLOR ON REPRODUCTION
    VICTOR EROSCHENKO; Fiscal Year: 1990
    The pesticide methoxychlor is presently in wide use as a substitute for the banned DDT. Biochemical research has established that the pesticide has estrogenic action; however, very little data are available concerning the effects of ..
  50. ENVIRONMENTAL RISK FACTORS AND BREAST CANCER IN THE NHS
    David Hunter; Fiscal Year: 1993
    ..S. These hypotheses are: 1. That levels of DDE (a metabolite of DDT) and PCBs are higher in stored blood specimens from women who develop breast cancer compared with women who do not ..
  51. ENVIRONMENTAL AND GENETIC DETERMINANTS OF BREAST CANCER
    Jo Freudenheim; Fiscal Year: 1993
    Proposed here is a study of the role of total PCBs, individual PCB congeners, DDT and mirex in the etiology of postmenopausal breast cancer. Serum levels of these environmental contaminants will be evaluated...
  52. CELL CELL COMMUNICATION IN CARCINOGENESIS
    James Trosko; Fiscal Year: 1999
    ..Based on (a) the demonstration that many chemical tumor promoters (i. e., TPA, DDT, TCDD, saccharin, phenobarbital, etc...
  53. PRENATAL EXPOSURE TO ORGANOCHLORINE AND FECUNDABILITY
    BARBARA COHN; Fiscal Year: 2000
    ..This epidemiological study will investigate the inter-generational effects of exposure to DDT/DDE and the PCBs in a subset of a unique study population, the Child Health and Development Studies (CHDS), ..
  54. ENVIRONMENTAL ANTI-ANDROGENS AND AR AUTOREGULATION
    EDDY YANG; Fiscal Year: 2005
    ..Studies suggest that two such chemicals, DDE (a metabolite of the pesticide DDT) and M2 (a metabolite of the fungicide vinclozolin) inhibit AR DNA-binding and the subsequent transactivation of ..
  55. Reducing pesticide exposures to farmworker children.
    Brenda Eskenazi; Fiscal Year: 2005
    ....
  56. In Utero Organochlorine Exposure & Breast Density
    BARBARA COHN; Fiscal Year: 2009
    ..hypothesis that in-utero exposure to environmental endocrine-active compounds (organochlorine compounds, p,p'-DDT, p,p'-DDE, o,p'-DDT and individual PCB congeners) alters breast density in women measured at 40-44 years ..
  57. Endocrine Disruptors and Neurodevelopmental Outcomes
    Brenda Eskenazi; Fiscal Year: 2004
    ..This study will provide the first data on exposure and health effects of ED pesticides in a highly exposed population, complete the exposure profile of CHAMACOS children, and target interventions to reduce child exposures. ..
  58. PBDEs, DDT and Neurodevelopment in School-Aged Mexican-American Children
    Brenda Eskenazi; Fiscal Year: 2010
    ..Dichlorodiphenyltrichloroethane (DDT) was used as recently as 2000 in some countries, such as Mexico, and continues to be used in others for malaria ..
  59. Pregnancy Hormones, Genes, & Offspring Health
    BARBARA COHN; Fiscal Year: 2004
    ..The SNP library will be a resource of unparalleled power that will be used in conjunction with emerging identification of relevant polymorphisms by the NIEHS Environmental Genome Project to study gene-environment interactions. ..
  60. Genetic damage in the sperm and blood of workers exposed to benzene
    Brenda Eskenazi; Fiscal Year: 2008
    ..Lastly, this study is one of the first to investigate the relative sensitivities of sperm and blood cells to chromosomal defects induced by benzene. [unreadable] [unreadable] [unreadable]..
  61. Fetal Basis of Sexual Dysfunction: Brain Differentiation
    D N Rao Veeramachaneni; Fiscal Year: 2007
    ..By using a relevant and yet practical animal model the proposed studies will advance the knowledge base in pollutant-induced sexual/erectile dysfunction, an area pivotal to reproductive health/success in humans. [unreadable] [unreadable]..