chlorinated hydrocarbons

Summary

Top Publications

  1. ncbi A strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes: results from the National Health and Examination Survey 1999-2002
    Duk Hee Lee
    Department of Preventive Medicine, School of Medicine, Kyungpook University, 101 Dongin dong, Jung Gu, Daegu, Korea 700 422
    Diabetes Care 29:1638-44. 2006
  2. ncbi Semen quality and exposure to persistent organochlorine pollutants
    Gunnar Toft
    Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark
    Epidemiology 17:450-8. 2006
  3. ncbi Smoking as a determinant of high organochlorine levels in Greenland
    Bente Deutch
    Centre of Arctic Environmental Medicine, Aarhus University, Aarhus, Denmark
    Arch Environ Health 58:30-6. 2003
  4. ncbi Exposure to CB-153 and p,p'-DDE and bone mineral density and bone metabolism markers in middle-aged and elderly men and women
    Ewa Wallin
    Department of Occupational and Environmental Medicine, Institute of Laboratory Medicine, Lund University Hospital, 221 85, Lund, Sweden
    Osteoporos Int 16:2085-94. 2005
  5. ncbi Exposure of Inuit in Greenland to organochlorines through the marine diet
    P Bjerregaard
    Section for Research in Greenland, National Institute of Public Health, Copenhagen, Denmark
    J Toxicol Environ Health A 62:69-81. 2001
  6. pmc Effect of endosulfan on male reproductive development
    Habibullah Saiyed
    National Institute of Occupational Health Indian Council of Medical Research, Meghani Nagar, Ahmedabad, India
    Environ Health Perspect 111:1958-62. 2003
  7. ncbi High human plasma levels of organochlorine compounds in Greenland. Regional differences and lifestyle effects
    B Deutch
    Department of Environmental and Occupational Medicine, Aarhus University
    Dan Med Bull 47:132-7. 2000
  8. ncbi Increased plasma levels of toxic pollutants accompanying weight loss induced by hypocaloric diet or by bariatric surgery
    Olivier Hue
    Department of Social and Preventive Medicine, Laval University, Quebec, Canada
    Obes Surg 16:1145-54. 2006
  9. pmc Organochlorine exposure and incidence of diabetes in a cohort of Great Lakes sport fish consumers
    Mary Turyk
    Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, Chicago, Illinois 60612, USA
    Environ Health Perspect 117:1076-82. 2009
  10. pmc Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: a cross-sectional study
    Gunnar Toft
    Department of Occupational Medicine, Aarhus University Hospital, Noerrebrogade 44, Build, 2C, DK 8000 Aarhus C, Denmark
    Environ Health 4:26. 2005

Detail Information

Publications217 found, 100 shown here

  1. ncbi A strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes: results from the National Health and Examination Survey 1999-2002
    Duk Hee Lee
    Department of Preventive Medicine, School of Medicine, Kyungpook University, 101 Dongin dong, Jung Gu, Daegu, Korea 700 422
    Diabetes Care 29:1638-44. 2006
    ..Low-level exposure to some persistent organic pollutants (POPs) has recently become a focus because of their possible link with the risk of diabetes...
  2. ncbi Semen quality and exposure to persistent organochlorine pollutants
    Gunnar Toft
    Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark
    Epidemiology 17:450-8. 2006
    ..The majority of studies have been conducted among selected populations of infertility clients or among occupational cohorts including a limited number of participants...
  3. ncbi Smoking as a determinant of high organochlorine levels in Greenland
    Bente Deutch
    Centre of Arctic Environmental Medicine, Aarhus University, Aarhus, Denmark
    Arch Environ Health 58:30-6. 2003
    ..These findings confirm that the source of POPs among the Inuit in Greenland is diet, but smoking is an important determinant of POP bioaccumulation. Smoking cessation may provide a means to lower the body burden of POPs...
  4. ncbi Exposure to CB-153 and p,p'-DDE and bone mineral density and bone metabolism markers in middle-aged and elderly men and women
    Ewa Wallin
    Department of Occupational and Environmental Medicine, Institute of Laboratory Medicine, Lund University Hospital, 221 85, Lund, Sweden
    Osteoporos Int 16:2085-94. 2005
    ..In conclusion, the results did not provide any support for the hypothesis that the current exposure levels to POC constitute a hazard for impaired bone metabolism in the general Swedish population...
  5. ncbi Exposure of Inuit in Greenland to organochlorines through the marine diet
    P Bjerregaard
    Section for Research in Greenland, National Institute of Public Health, Copenhagen, Denmark
    J Toxicol Environ Health A 62:69-81. 2001
    ..The age pattern indicates that bioaccumulation of PCB started in the 1950s, which is a likely date for the introduction of the compounds into the Arctic environment...
  6. pmc Effect of endosulfan on male reproductive development
    Habibullah Saiyed
    National Institute of Occupational Health Indian Council of Medical Research, Meghani Nagar, Ahmedabad, India
    Environ Health Perspect 111:1958-62. 2003
    ..Our study results suggest that endosulfan exposure in male children may delay sexual maturity and interfere with sex hormone synthesis. Our study is limited by small sample size and nonparticipation...
  7. ncbi High human plasma levels of organochlorine compounds in Greenland. Regional differences and lifestyle effects
    B Deutch
    Department of Environmental and Occupational Medicine, Aarhus University
    Dan Med Bull 47:132-7. 2000
    ..It comprises a regional study from six districts and an ongoing study of pregnant women and infants...
  8. ncbi Increased plasma levels of toxic pollutants accompanying weight loss induced by hypocaloric diet or by bariatric surgery
    Olivier Hue
    Department of Social and Preventive Medicine, Laval University, Quebec, Canada
    Obes Surg 16:1145-54. 2006
    ....
  9. pmc Organochlorine exposure and incidence of diabetes in a cohort of Great Lakes sport fish consumers
    Mary Turyk
    Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, Chicago, Illinois 60612, USA
    Environ Health Perspect 117:1076-82. 2009
    ..Prospective studies, however, have been lacking...
  10. pmc Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: a cross-sectional study
    Gunnar Toft
    Department of Occupational Medicine, Aarhus University Hospital, Noerrebrogade 44, Build, 2C, DK 8000 Aarhus C, Denmark
    Environ Health 4:26. 2005
    ..Persistent organochlorine pollutants (POPs) may interfere with reproductive function but direct evidence in humans is very limited...
  11. ncbi Target-specific action of organochlorine compounds in reproductive and nonreproductive tissues of estrogen-reporter male mice
    R Villa
    3rd Laboratory Biotechnology, Civic Hospital of Brescia, 25123 Brescia, Italy
    Toxicol Appl Pharmacol 201:137-48. 2004
    ..We conclude that these organochlorines modulate differently the expression of estrogen-regulated genes in male mice. Their effect is tissue- and compound-specific and is dependent on the energetic balance...
  12. ncbi Association between serum concentrations of persistent organic pollutants and insulin resistance among nondiabetic adults: results from the National Health and Nutrition Examination Survey 1999-2002
    Duk Hee Lee
    Department of Preventive Medicine, School of Medicine, Kyungpook National University, 101 Dongin dong, Jung Gu, Daegu, Korea 700 422
    Diabetes Care 30:622-8. 2007
    ..S population with background exposure to POPs. Here, we investigated POPs and insulin resistance, a frequent pathogenic precursor of type 2 diabetes...
  13. pmc Immune function biomarkers in children exposed to lead and organochlorine compounds: a cross-sectional study
    Wilfried Karmaus
    Department of Epidemiology, Michigan State University, B601 West Fee Hall, East Lansing, MI 48824, USA
    Environ Health 4:5. 2005
    ..Children are at greater risk for exposure to these environmental toxicants, but very little data exist on simultaneous exposures to these substances...
  14. ncbi Organochlorine levels in adipose tissue of women from a littoral region of Argentina
    Mónica Muñoz-de-Toro
    Laboratorio de Endocrinologia y Tumores Hormonodependientes, School of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, Santa Fe, Argentina
    Environ Res 102:107-12. 2006
    ..0003) and the age of the patient (p = 0.0002). The frequency and levels of OCCs found in our study population raise concerns regarding Argentinean exposure to these endocrine disruptors...
  15. ncbi Organochlorine exposures during pregnancy and infant size at birth
    Sharon K Sagiv
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Epidemiology 18:120-9. 2007
    ..Organochlorines, including polychlorinated biphenyls (PCBs) and pesticides, are environmentally persistent contaminants that concentrate in the food chain as well in human adipose tissue and readily cross the placenta...
  16. ncbi Incidence of hospitalized osteoporotic fractures in cohorts with high dietary intake of persistent organochlorine compounds
    Ann Kathrine Alveblom
    Department of Occupational and Environmental Medicine, Lund University Hospital, 221 85 Lund, Sweden
    Int Arch Occup Environ Health 76:246-8. 2003
    ..The goal of this study was to assess whether a high dietary intake of POCs through fatty fish from the Baltic Sea may result in an increased incidence of osteoporotic fractures...
  17. ncbi Receptor-mediated effects of chlorinated hydrocarbons
    B Fischer
    Department of Anatomy and Cell Biology, Martin Luther University Faculty of Medicine, Halle Saale, Germany
    Andrologia 32:279-83. 2000
    ..transcription factor and was originally described as a mediator of the toxic effects of dioxins and other chlorinated hydrocarbons such as polychlorinated biphenyls...
  18. ncbi Strategies for the aerobic co-metabolism of chlorinated solvents
    L Semprini
    Department of Civil, Construction, and Environmental Engineering, Oregon State University, Corvallis 97331 2302, USA
    Curr Opin Biotechnol 8:296-308. 1997
    ..Many factors can enhance co-metabolic transformations, such as nutrients and available energy sources...
  19. ncbi Plasma organochlorine concentrations in endurance athletes and obese individuals
    Catherine Pelletier
    Physical Activity Sciences Laboratory and Division of Kinesiology, PEPS and Department of Food Science and Nutrition, Laval University, Ste Foy Québec, Canada
    Med Sci Sports Exerc 34:1971-5. 2002
    ..Their plasma concentrations were compared in three groups of individuals with different body fatness characteristics: endurance athletes, lean sedentary subjects, and obese individuals...
  20. ncbi Body burdens and tissue concentrations of organochlorines in polar bears (Ursus maritimus) vary during seasonal fasts
    S C Polischu
    Office of the Vice President Research, University of Saskatchewan, Saskatoon, Canada
    Environ Pollut 118:29-39. 2002
    ..Since developing young may be susceptible to the effects of environmental contaminants, the increased exposure of nursing cubs to OCs during a fast by their mothers is noteworthy...
  21. ncbi Kinetic models for volatile chlorinated hydrocarbons removal by zero-valent iron
    Václav Janda
    Department of Water Technology and Environmental Engineering, Institute of Chemical Technology Prague, Technicka 5, CZ 166 28 Prague 6, Czech Republic
    Chemosphere 54:917-25. 2004
    ..Regression analysis proved, that the first-order kinetic is not suitable for the modelling of chlorinated hydrocarbons dechlorination...
  22. ncbi Photodegradation of chlorinated hydrocarbons in the presence and absence of dissolved oxygen in water
    H Shirayama
    Water Pollution Section, Toyama Prefectural Environmental Science Research Center, Kosugi, Imizu gun, Toyama 939 0363, Japan
    Water Res 35:1941-50. 2001
    The photodegradation rates of seven chlorinated hydrocarbons; C2Cl4, C2HCl3, C2H4Cl2, 1,1,1-C2H3Cl3, 1,1,2-C2H3Cl3, CHCl3, CCl4 were investigated under the UV bandwidths of 185 and 254 nm in the presence and absence of dissolved oxygen (..
  23. ncbi Environmental and lifestyle factors for organochlorine exposure among women living in Southern Spain
    I Cerrillo
    Laboratory of Medical Investigations, School of Medicine, University of Granada, Hospital Clinico, 18071 Granada, Spain
    Chemosphere 62:1917-24. 2006
    ..Research is required on women occupationally exposed to a selected group of organochlorine pesticides, especially those of reproductive age, as a basis for preventive action...
  24. ncbi Geographical distribution of organochlorine pesticides (OCPs) in polar bears (Ursus maritimus) in the Norwegian and Russian Arctic
    E Lie
    National Veterinary Institute, PO Box 8156 Dep, Oslo N 0033, Norway
    Sci Total Environ 306:159-70. 2003
    ..This may imply the presence of a significant pollution source in the Russian Arctic area. The study suggests that the western Russian Arctic is the most contaminated region of the Arctic and warrants further research...
  25. ncbi Prenatal organochlorine pesticides in placentas from Finland: exposure of male infants born during 1997-2001
    H Shen
    Placenta 26:512-4. 2005
  26. ncbi Burden of organochlorine pesticides in blood and its effect on thyroid hormones in women
    Minakshi Rathore
    Department of Zoology, University of Rajasthan, Jaipur, India
    Sci Total Environ 295:207-15. 2002
    ..The correlation analysis for dieldrin and depleted T4 levels in hypothyroid women elicited an inverse relationship between them...
  27. ncbi Health of tree swallow (Tachycineta bicolor) nestlings exposed to chlorinated hydrocarbons in the St Lawrence River basin. Part I. Renal and hepatic vitamin A concentrations
    Barbara Martinovic
    Department of Biology, University of Ottawa, Ottawa, Ontario, Canada
    J Toxicol Environ Health A 66:1053-72. 2003
    ..Lower circulating levels and higher tissue concentrations of retinoids may result in compromised immune function and reduced reproductive success in adult birds...
  28. ncbi Serum organochlorine levels and history of lactation in Egypt
    Amr S Soliman
    Department of Epidemiology, The University of Texas, M D Anderson Cancer Center, Box 189 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Environ Res 92:110-7. 2003
    ..Organochlorine serum level was not a risk factor of breast cancer in this population...
  29. pmc A cross-sectional study of the association between persistent organochlorine pollutants and diabetes
    Lars Rylander
    Division of Occupational and Environmental Medicine and Psychiatric Epidemiology, Department of Laboratory Medicine, University Hospital, SE 221 85 Lund, Sweden
    Environ Health 4:28. 2005
    ..We have assessed the association between serum levels of POPs and prevalence of diabetes in Swedish fishermen and their wives, with high consumption of fatty fish from the Baltic Sea...
  30. pmc Occupational exposure to organochlorine insecticides and cancer incidence in the Agricultural Health Study
    Mark P Purdue
    Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA
    Int J Cancer 120:642-9. 2007
    ....
  31. ncbi Variation, levels and profiles of organochlorines and brominated flame retardants in great tit (Parus major) eggs from different types of sampling locations in Flanders (Belgium)
    Evi Van den Steen
    Department of Biology, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium
    Environ Int 34:155-61. 2008
    ..In conclusion, our results showed that the characteristics of a sampling location influence both the levels and profiles of PCBs, OCPs and PBDEs...
  32. ncbi Dioxins, polychlorinated biphenyls and other organohalogen compounds in human milk. Levels, correlations, trends and exposure through breastfeeding
    Peter Fürst
    Chemisches Landes und Staatliches Veterinäruntersuchungsamt, Munster, Germany
    Mol Nutr Food Res 50:922-33. 2006
    ..Moreover, in contrast to PCB, PBDE show no significant correlation with PCDD/PCDF in human milk, which might be interpreted as an indication for another mode of human exposure...
  33. ncbi Interactions of persistent environmental organohalogens with the thyroid hormone system: mechanisms and possible consequences for animal and human health
    A Brouwer
    Department of Toxicology, Wageningen Agricultural University, The Netherlands
    Toxicol Ind Health 14:59-84. 1998
    ....
  34. ncbi Distribution of PCDDs/PCDFs and Co-PCBs in human maternal blood, cord blood, placenta, milk, and adipose tissue: dioxins showing high toxic equivalency factor accumulate in the placenta
    Go Suzuki
    Department of Bioresource Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro City, Hokkaido, Japan
    Biosci Biotechnol Biochem 69:1836-47. 2005
    ..But, the concentrations and relative percentages of congeners differed among the various samples, suggesting that congeners showing high toxic equivalency factor accumulate in the placenta...
  35. pmc Incident diabetes and pesticide exposure among licensed pesticide applicators: Agricultural Health Study, 1993-2003
    M P Montgomery
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Am J Epidemiol 167:1235-46. 2008
    ..Long-term exposure from handling certain pesticides, in particular, organochlorine and organophosphate insecticides, may be associated with increased risk of diabetes...
  36. ncbi Global assessment of organic contaminants in farmed salmon
    Ronald A Hites
    School of Public and Environmental Affairs, Indiana University, Bloomington, IN 47405, USA
    Science 303:226-9. 2004
    ..Risk analysis indicates that consumption of farmed Atlantic salmon may pose health risks that detract from the beneficial effects of fish consumption...
  37. ncbi Toxicity of trans-nonachlor to Sprague-Dawley rats in a 90-day feeding study
    Genevieve Bondy
    Toxicology Research Division, Food Directorate, Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada, K1A 0L2
    Food Chem Toxicol 42:1015-27. 2004
    ..Differences in target organ responses in male and female rats indicate that the sex-related metabolic differences affecting trans-nonachlor bioaccumulation and elimination merit further study...
  38. ncbi Organochlorines, p53 mutations in relation to breast cancer risk and survival. A Danish cohort-nested case-controls study
    Annette Pernille Høyer
    The Copenhagen Center for Prospective Population Studies, Denmark
    Breast Cancer Res Treat 71:59-65. 2002
    ..These preliminary results suggest that p53 mutations may have a modifying effect on at least the breast cancer risk associated with exposures to organochlorines...
  39. ncbi Carry-over of persistent organochlorine pesticides through placenta to fetus
    S M Waliszewski
    Instituto de Medicina Forense de la Universidad Veracruzana, Veracruz, Ver, Mexico
    Salud Publica Mex 42:384-90. 2000
    ..To establish their distribution in the human body, the concentration gradients of organochlorine pesticides between these compartments were determined...
  40. ncbi Cancer incidence among workers potentially exposed to chlorinated solvents in an electronics factory
    Yung Ming Chang
    Graduate Institute of Life Sciences, National Defense Medical Center, National Defense University, Taiwan, Republic of China
    J Occup Health 47:171-80. 2005
    ..This study provides no evidence that exposure to chlorinated organic solvents at the electronics factory was associated with elevated human cancers. Dominant short-term employees may bias the cancer risk toward false positive...
  41. pmc Increased mortality odds ratio of male liver cancer in a community contaminated by chlorinated hydrocarbons in groundwater
    L J H Lee
    Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, Taiwan
    Occup Environ Med 60:364-9. 2003
    To investigate the association between cancer mortality risk and exposure to chlorinated hydrocarbons in groundwater of a downstream community near a contaminated site.
  42. ncbi Organochlorines affect the steroid hormone cortisol in free-ranging polar bears (Ursus maritimus) at Svalbard, Norway
    Irma Oskam
    Department of Production Animal Clinical Science, Norwegian School of Veterinary Science, Oslo, Norway
    J Toxicol Environ Health A 67:959-77. 2004
    ..Despite the complexity on stress responses and the interactions with environmental factors, this study demonstrated that high concentrations of OCs in polar bears might alter plasma cortisol concentrations...
  43. ncbi The association between organochlorine and thyroid hormone levels in cord serum: a study from northern Thailand
    R Asawasinsopon
    Environmental Science Ph D Program, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand
    Environ Int 32:554-9. 2006
    ..76, P = 0.019). These results therefore suggest that exposure to DDT and its metabolites during fetal development may cause some effects on thyroid hormonal status in infants...
  44. ncbi Concentrations of environmental chemicals associated with neurodevelopmental effects in U.S. population
    Larry L Needham
    Organic Analytical Toxicology Branch, Mailstop F17, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341 3724, USA
    Neurotoxicology 26:531-45. 2005
    ..S. population. These data will continue to be collected in 2-year cycles and thus allow changes in human levels to be followed...
  45. pmc Inter-population variations in concentrations, determinants of and correlations between 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE): a cross-sectional study of 3161 men and women from Inuit and
    Bo A G Jonsson
    Department of Occupational and Environmental Medicine, Lund University Hospital, SE 221 85 Lund, Sweden
    Environ Health 4:27. 2005
    ....
  46. pmc Organochlorine compounds and concentrations of thyroid stimulating hormone in newborns
    N Ribas-Fito
    Respiratory and Environmental Health Research Unit, Institut Municipal d Investigacio Medica, Barcelona, Spain
    Occup Environ Med 60:301-3. 2003
    ..To assess the association between prenatal exposure to organochlorine compounds and thyroid status in newborns from an area with high levels of hexachlorobenzene (HCB)...
  47. ncbi Investigation of organochlorine pesticides (OCPs) in mollusks collected from coastal sites along the Chinese Bohai Sea from 2002 to 2004
    Yawei Wang
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, P O Box 2871, 18 Shuangqing Road, Haidian District, Beijing 100085, China
    Environ Pollut 146:100-6. 2007
    ..Principal component analysis (PCA) was also used for determining the polluting characters existing in this selected field...
  48. ncbi Exposure of women to organochlorine pesticides in Southern Spain
    Begoña Botella
    Laboratory of Medical Investigations, Department of Radiology, School of Medicine, Hospital Clinico, University of Granada, 18071 Granada, Spain
    Environ Res 96:34-40. 2004
    ..Because many of these chemicals can mobilize during pregnancy and lactation, further research is warranted to interpret the health consequences for the children of such exposure...
  49. ncbi Exposure to organochlorine compounds and effects on ovarian function
    Gayle C Windham
    Environmental Health Investigations Branch, Department of Health Services, Oakland, California 94612, USA
    Epidemiology 16:182-90. 2005
    ..Some chemicals appear to have hormonally active properties in animals, but data in humans are sparse. Therefore, we examined ovarian function in relation to organochlorine compound levels...
  50. pmc Thyroid hormones in pregnancy in relation to environmental exposure to organochlorine compounds and mercury
    Larissa Takser
    Laboratoire de Physiologie Materno Foetale, Universite du Quebec a Montreal, Montreal, Quebec, Canada
    Environ Health Perspect 113:1039-45. 2005
    ..Cord serum free thyroxin was negatively correlated with inorganic Hg. These results suggest that at even low levels of exposure, persistent environmental contaminants can interfere with thyroid status during pregnancy...
  51. ncbi Organochlorines in carpet dust and non-Hodgkin lymphoma
    Joanne S Colt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
    Epidemiology 16:516-25. 2005
    ..The incidence of non-Hodgkin lymphoma (NHL) has risen over the past several decades. Reasons for this increase are largely unexplained...
  52. ncbi A proportionate cancer morbidity ratio study of workers exposed to chlorinated organic solvents in Taiwan
    Yung Ming Chang
    Graduate Institute of Life Sciences, National Defense Medical Center, 161 Ming Chun East Road, Sec 6, Nei Hu, Taipei, Taiwan, 114, ROC
    Ind Health 41:77-87. 2003
    ..Since this association has never been reported in the previous studies, further study is needed to clarify the association...
  53. ncbi Associations between serum levels of selected organochlorine compounds and endometriosis in infertile Japanese women
    Hiromasa Tsukino
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center Tsukiji, Tokyo, Japan
    Environ Res 99:118-25. 2005
    ..06). The results of this study provide some evidence that serum levels of these organochlorine compounds are not associated with an increased risk of endometriosis in infertile Japanese women...
  54. ncbi In utero and lactational exposure to an environmentally relevant organochlorine mixture disrupts reproductive development and function in male rats
    Mohamed Kheir Idris Anas
    Centre de Recherche en Biologie de la Reproduction, Departement de sciences animales, Universite Laval, Quebec, Canada G1K 7P4
    Biol Reprod 73:414-26. 2005
    ....
  55. ncbi Epidemiological evidence on reproductive effects of persistent organochlorines in humans
    Gunnar Toft
    Department of Occupational Medicine, Aarhus University Hospital, Noerrebrogade 44, Build 2C, 8000 Aarhus C, Denmark
    Reprod Toxicol 19:5-26. 2004
    ..Due to inherent methodological problems in several of the available studies, additional research is needed to fully elucidate the possible adverse effects of organochlorines on human reproductive health...
  56. ncbi Human health risk assessment of organochlorines associated with fish consumption in a coastal city in China
    Q T Jiang
    Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong
    Environ Pollut 136:155-65. 2005
    ..The hazard ratios (HRs), based on non-cancer endpoints were all less than 1.0, while the HRs based on cancer were greater than 1.0 for certain contaminants based on the 95th centile concentration in fish tissue...
  57. ncbi Distribution of polychlorinated biphenyls, organochlorine pesticides and polybrominated diphenyl ethers in human umbilical cord serum, maternal serum and milk from Wielkopolska region, Poland
    Kamila Jaraczewska
    Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, 6 Grunwaldzka St, 60 780 Poznan, Poland
    Sci Total Environ 372:20-31. 2006
    ..4), with BDE 47 being always the most abundant PBDE congener and, together with BDE 153, being present in all samples. In general, results found in the investigated group are at the low end of the concentration range measured in Europe...
  58. ncbi PCBs and organochlorine pesticides (OCPs) in edible fish and shellfish from China
    Naiqing Yang
    Department of Environment Conservation, Ehime University, Tarumi 3 5 7, Matsuyama 790 8566, Japan
    Chemosphere 63:1342-52. 2006
    ..9 ng/g on wet weight basis, respectively. The daily intake of PCBs and organochlorine pesticides ingested by people living in these cities in China through fish and shellfish was estimated and compared with those observed in other areas...
  59. pmc Risk of non-Hodgkin's lymphoma and prediagnostic serum organochlorines: beta-hexachlorocyclohexane, chlordane/heptachlor-related compounds, dieldrin, and hexachlorobenzene
    Kenneth P Cantor
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7240, USA
    Environ Health Perspect 111:179-83. 2003
    ..These findings do not support the hypothesis that the organochlorine compounds included in this study are strongly linked to the development of NHL. The possibility of a weak association cannot be excluded by these data...
  60. pmc Distribution of persistent organochlorine contaminants in infertile patients from Tanzania and Germany
    Jürgen M Weiss
    Department of Obstetrics and Gynecology, University Clinic Luebeck, Ratzeburger Allee 160, D 23538, Luebeck, Germany
    J Assist Reprod Genet 23:393-9. 2006
    ..To test whether environmental pollutants could affect fertility in humans...
  61. ncbi Serum levels of several organochlorine pesticides in farmers correspond with dietary exposure and local use history
    J W Brock
    National Center for Environmental Health NCEH, Centers for Disease Control, Atlanta, GA 30341, USA
    Toxicol Ind Health 14:275-89. 1998
    ..Previous reported use of chlordane on the North Carolina farms corresponded with measurable dietary levels of chlordance and higher serum trans-nonachlor levels than the levels in Iowa farm families...
  62. ncbi Thyroid toxicity due to subchronic exposure to a complex mixture of 16 organochlorines, lead, and cadmium
    Michael G Wade
    Growth and Development Section, Environmental and Occupational Toxicology Section, Environmental Health Directorate, Health Canada, Tunney s Pasture, Ottawa, Ontario, Canada K1A 0L2
    Toxicol Sci 67:207-18. 2002
    ..These results demonstrate that low doses of ubiquitous environmental contaminants can alter HPT physiology in sexually mature males...
  63. ncbi Chronic toxicity of a mixture of chlorinated alkanes and alkenes in ICR mice
    Fun In Wang
    Department of Veterinary Medicine, College of Agriculture, National Taiwan University, Taipei
    J Toxicol Environ Health A 65:279-91. 2002
    ..This study has demonstrated that the CA mixture is a potential carcinogen to male and female mice. These animal toxicology data may be important in assessing the health effects of individuals exposed to the CA mixture...
  64. ncbi Health risk assessment on residents exposed to chlorinated hydrocarbons contaminated in groundwater of a hazardous waste site
    Lukas Jyuhn Hsiarn Lee
    Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei
    J Toxicol Environ Health A 65:219-35. 2002
    ..measured contaminant levels and exposure parameters to perform health risk assessment on seven chlorinated hydrocarbons. We measured groundwater concentrations of vinyl chloride, tetrachloroethylene, trichloroethylene, 1,1-..
  65. ncbi Organochlorine pesticides in seafood products from southern China and health risk assessment
    Jian yang Guo
    State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China
    Environ Toxicol Chem 26:1109-15. 2007
    ..Therefore, continual monitoring of OCPs in various environment compartments, including biota and abiota, urgently is needed to mitigate effectively the impact of OCPs, particularly DDTs, on human health and the ecological environment...
  66. ncbi Plasma organochlorine levels and subsequent risk of breast cancer among Japanese women: a nested case-control study
    Motoki Iwasaki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo, 104 0045, Japan
    Sci Total Environ 402:176-83. 2008
    ..Our data do not support the hypothesis that plasma levels of p,p'-DDT, p,p'-DDE, HCB, and beta-HCH are associated with an overall increased risk of breast cancer among Japanese women...
  67. pmc Organochlorine exposures influence on breast cancer risk and survival according to estrogen receptor status: a Danish cohort-nested case-control study
    A P Høyer
    The Copenhagen Center for Prospective Population Studies, Harsdorffsvej 1B, 2tv, DK 1874 Frederiksberg C, Denmark
    BMC Cancer 1:8. 2001
    ..As estrogen receptor positive and negative breast cancer may represent different entities of the disease, this study was undertaken to evaluate organochlorines influence on breast cancer risk and survival according to receptor status...
  68. ncbi Organochlorines and polybrominated diphenyl ethers in four geographically separated populations of Atlantic salmon (Salmo salar)
    Tore Christian Svendsen
    Department of Chemistry, Biotechnology, and Environmental Engineering, Aalborg University, Sohngardsholmsvej 57, DK 9000, Aalborg, Denmark
    J Environ Monit 9:1213-9. 2007
    ..The PBDE pattern changed between locations, with a significant separation of the fish from the freshwater and marine environment when analyzed using principal component analysis...
  69. pmc Prevalence of self-reported diabetes and exposure to organochlorine pesticides among Mexican Americans: Hispanic health and nutrition examination survey, 1982-1984
    Shanna Cox
    Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Environ Health Perspect 115:1747-52. 2007
    ..Higher serum levels of organochlorine pesticides in Mexican Americans have been reported. Few studies have explored the association between pesticide exposure and diabetes...
  70. pmc Infant exposure to chemicals in breast milk in the United States: what we need to learn from a breast milk monitoring program
    J S LaKind
    LaKind Associates, LLC, Catonsville, Maryland 21228, USA
    Environ Health Perspect 109:75-88. 2001
    ..A program of breast milk monitoring would serve to provide the information needed to assess infant exposures during breast-feeding and develop scientifically sound information on benefits and risks of breast-feeding in the United States...
  71. ncbi Evaluation of Mexican American migrant farmworker work practices and organochlorine pesticide metabolites
    M A Hernández-Valero
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Am J Ind Med 40:554-60. 2001
    ..Epidemiologic studies often must rely upon questionnaire data to assess past exposures. The ability of questionnaires to rank migrant farmworkers according to past pesticide exposure is not known...
  72. ncbi Organochlorines and endometrial cancer risk
    E Weiderpass
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Cancer Epidemiol Biomarkers Prev 9:487-93. 2000
    ..1 (95% confidence interval, 0.6-2.2; P for trend, 0.90). Our data do not support the hypothesis that the organochlorine exposure studied increases the risk for endometrial cancer...
  73. ncbi Organochlorines and heavy metals in pregnant women from the Disko Bay area in Greenland
    P Bjerregaard
    National Institute of Public Health, Section for Research in Greenland, Copenhagen, Denmark
    Sci Total Environ 245:195-202. 2000
    ..The contaminants are potentially toxic for several organ systems but the high concentrations of pollutants have so far not been shown to influence health in Greenland...
  74. pmc Serum organochlorine pesticide residues and risk of testicular germ cell carcinoma: a population-based case-control study
    Mary L Biggs
    Department of Biostatistics, School of Public Health and Community Medicine, University of Washington, Box 354922, Seattle, WA 98195 4922, USA
    Cancer Epidemiol Biomarkers Prev 17:2012-8. 2008
    ..Due to uncertainty regarding how well organochlorine levels measured in adulthood reflect exposures during early life, further research is needed using exposure measurements collected in utero or during infancy...
  75. pmc Changes in maternal serum chlorinated pesticide concentrations across critical windows of human reproduction and development
    Michael S Bloom
    Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, One University Place, Rm 153, Rensselaer, NY 12144, USA
    Environ Res 109:93-100. 2009
    ..This underscores the importance of timing biospecimen collection to critical windows for development in the assessment of reproductive and/or developmental effects...
  76. ncbi Serum organochlorines and breast cancer risk in Japanese women: a case-control study
    Hiroaki Itoh
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Causes Control 20:567-80. 2009
    ..Here, we examined these associations in Japanese women in the largest study in Asian women to date...
  77. ncbi Association of maternal blood pressure and hemoglobin level with organochlorines in human milk
    M K J Siddiqui
    Analytical Toxicology, Industrial Toxicology Research Centre, Lucknow, India
    Hum Exp Toxicol 21:1-6. 2002
    ..05). These results highlight the need for periodic monitoring to determine organochlorine contamination in human milk and assess their impact on mother and on neonatal health...
  78. pmc Host and environmental determinants of polychlorinated aromatic hydrocarbons in serum of adolescents
    Tim S Nawrot
    Studiecoördinatiecentrum, Hypertensie en Cardiovasculaire Revalidatie Eenheid, Departement Moleculair en Cardiovasculair Onderzoek, Katholieke Universiteit Leuven, Faculteit Geneeskunde, Leuven, Belgium
    Environ Health Perspect 110:583-9. 2002
    ....
  79. ncbi Polychlorinated camphenes (toxaphenes), polybrominated diphenylethers and other halogenated organic pollutants in glaucous gull (Larus hyperboreus) from Svalbard and Bjørnøya (Bear Island)
    Dorte Herzke
    Norwegian Institute for Air Research, The Polar Environmental Centre, Hjalmar Johansen gt 14 N 9296 Tromsø, Norway
    Environ Pollut 121:293-300. 2003
    ..Concentrations of toxaphenes and PBDEs were up to 100-times lower than the concentrations of PCB and some of the pesticides. PCB and p,p/-DDE constituted 90% of the contaminants found...
  80. pmc Determinants of serum concentrations of organochlorine compounds in Swedish pregnant women: a cross-sectional study
    Anders Glynn
    Swedish National Food Administration, Uppsala, Sweden
    Environ Health 6:2. 2007
    ....
  81. ncbi Elemental and organochlorine residues in bald eagles from Adak Island, Alaska
    Jordan H Stout
    U S Fish and Wildlife Service, Ecological Services, Anchorage Field Office, 605 West 4th Avenue, Room G 61, Anchorage, Alaska 99501, USA
    J Wildl Dis 38:511-7. 2002
    ..Furthermore, although mean polychlorinated biphenyl and pp'-dichlorodiphenyldichloroethylene concentrations were below acute toxic thresholds, they were surprisingly high given Adak Island's remote location...
  82. pmc Serum organochlorines and urinary porphyrin pattern in a population highly exposed to hexachlorobenzene
    Jordi Sunyer
    Respiratory and Environmental Research Unit, Institut Municipal d Investigacio Medica, Barcelona, Catalonia, Spain
    Environ Health 1:1. 2002
    ..We aimed at analysing the association of individual urinary porphyrins with the serum concentrations of HCB and other organochlorine compounds in this highly exposed population...
  83. ncbi Organochlorines and breast cancer risk
    Eugenia E Calle
    American Cancer Society, Atlanta, GA, USA
    CA Cancer J Clin 52:301-9. 2002
    ..Women concerned about possible organochlorine exposure can be reassured that available evidence does not suggest an association between these chemicals and breast cancer...
  84. ncbi Reproductive success and contaminants in tree swallows (Tachycineta bicolor) breeding at a wastewater treatment plant
    Patti L Dods
    Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, Canada
    Environ Toxicol Chem 24:3106-12. 2005
    ....
  85. ncbi Predictors of organochlorines in New York City pregnant women, 1998-2001
    Mary S Wolff
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, 1 Gustave Levy Pl, Box 1057, New York, NY 10029 6574, USA
    Environ Res 97:170-7. 2005
    ..In multivariate models, levels of OCs increased with age; DDE was higher in women not born in the US or Puerto Rico; PCB were higher in women who bought fresh fish and lower in those with higher body mass indices...
  86. ncbi Levels of persistent organochlorine contaminants in fish from Korea and their potential health risk
    U H Yim
    Southern Coastal Environment Research Division, Korea Ocean Research and Development Institute, 391 Jangmok ri, Jangmok myon, Geoje shi, 656 834, Korea
    Arch Environ Contam Toxicol 48:358-66. 2005
    ..04 ng/g based on total PCBs), but the other compounds were mostly below SV values. Based on the estimated SVs, PCB compounds were identified as potential chemicals of concern...
  87. ncbi Factors predicting organochlorine pesticide levels in pregnant Latina women living in a United States agricultural area
    A S A Bradman
    Center for Children s Environmental Health Research, School of Public Health, University of California, Berkeley, CA 94720 7380, USA
    J Expo Sci Environ Epidemiol 17:388-99. 2007
    ..Although the weight of evidence from this study indicates that most exposure occurred before moving to the United States, the results for HCB indicate the possibility of ongoing exposure in this country...
  88. ncbi Serum polychlorinated biphenyl and organochlorine insecticide concentrations in a Faroese birth cohort
    Dana B Barr
    Centers for Disease Control and Prevention, 4770 Buford Highway, Mailstop F17, Atlanta, GA 30341, USA
    Chemosphere 62:1167-82. 2006
    ....
  89. ncbi Use of the Nile monitor, Varanus niloticus L (Reptilia: Varanidae), as a bioindicator of organochlorine pollution in African wetlands
    P J Berny
    Laboratory of Diagnostic Toxicology, Ecole Nationale Veterinaire de Lyon, 1 avenue Bourgelat, B P 83, Marcy l Etoile, France, F 69280
    Bull Environ Contam Toxicol 77:359-66. 2006
  90. ncbi Leaf-air transfer of organochlorine pesticides from three selected vegetables
    Xinglun Yang
    State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences, 71 East Beijing Road, Nanjing 210008, China
    Environ Pollut 148:555-61. 2007
    ..Our work provided insight into the behavior of OCPs in the agroecosystem...
  91. ncbi Contamination profiles of heavy metals, organochlorine pesticides, polycyclic aromatic hydrocarbons and alkylphenols in sediment and oyster collected from marsh/estuarine Savannah GA, USA
    Kurunthachalam Senthil Kumar
    Department of Natural Sciences and Mathematics, Savannah State University, 3219 College Street, P O Box 20600, Savannah, GA 31404, USA
    Mar Pollut Bull 56:136-49. 2008
  92. ncbi Persistent chlordane concentrations in Long Island Sound sediment: implications from chlordane, 210Pb, and 137Cs profiles
    Lijia Yang
    Department of Earth and Atmospheric Sciences, City College of New York, CUNY, New York, New York 10031, USA
    Environ Sci Technol 41:7723-9. 2007
    ..S. Continued chlordane input and significant sediment mixing may have contributed to the persistent chlordane concentrations in surficial sediment, which poses long-term threats to benthic organisms in LIS...
  93. ncbi Distribution and fate of persistent organochlorine pesticides in coastal marine environment of Mumbai
    G G Pandit
    Environmental Assessment Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085, India
    Environ Int 32:240-3. 2006
    ..The alpha-HCH is found to be more dominant in fish samples whereas the gamma-HCH is major contributor in the sediment samples...
  94. ncbi [Occurrence of dissolved polychlorinated biphenyls and organic chlorinated pesticides in the surface water of Haihe River and Bohai ay, China]
    Tai Wang
    POPs Research Centre, Department of Environmental Science and Engineering, Tsinghua University, Beijing 100084, China
    Huan Jing Ke Xue 28:730-5. 2007
    ..The levels of PCBs and OCPs in Haihe River in this study are quite higher than the similar surface waters in China, while the levels in Bohai Bay are quite consistent with similar waters abroad...
  95. ncbi Screening ecological risk assessment of persistent organic pollutants in Mediterranean sea sediments
    Anna Gómez-Gutiérrez
    Department of Environmental Chemistry IIQAB CSIC, Jordi Girona 18 26, E 08034 Barcelona, Spain
    Environ Int 33:867-76. 2007
    ....
  96. ncbi Spatial distribution and accumulation of brominated flame retardants, polychlorinated biphenyls and organochlorine pesticides in blue mussels (Mytilus edulis) from coastal waters of Korea
    Karri Ramu
    Center for Marine Environmental Studies CMES, Ehime University, Matsuyama 790 8577, Japan
    Environ Pollut 148:562-9. 2007
    ..For all the compounds, higher concentrations were found in mussels from southeastern coast of Korea. The present study shows the importance of mussels as bioindicators for monitoring contaminants in coastal waters...
  97. ncbi Characterization of trace organic contaminants in marine sediment from Yeongil Bay, Korea: 1. Instrumental analyses
    Chul Hwan Koh
    School of Earth and Environmental Sciences Oceanography, College of Natural Sciences, Seoul National University, Seoul 151 742, Korea
    Environ Pollut 142:39-47. 2006
    ..Concentrations of PCBs and PAHs were great near shipyards and industrial complexes. Vertical profiles of PAHs and APs indicated that they have been associated with sediments since the 1950s...
  98. ncbi Quantification of low levels of organochlorine pesticides using small volumes (<or=100 microl) of plasma of wild birds through gas chromatography negative chemical ionization mass spectrometry
    Laura B Rivera-Rodríguez
    Centro de Investigaciones Biologicas del Noroeste, S C, Environmental Planning and Conservation Program, Mar Bermejo no 195, Col Playa Palo de Santa Rita, Ado Postal 128, La Paz, BCS 23090, Mexico
    Environ Pollut 148:654-62. 2007
    ..9 pg/microl for some OC pesticides. All levels in the food web in and around cultivated areas showed the presence of pesticides notwithstanding the small areas for agriculture existing in the desert of Baja California peninsula...
  99. ncbi Assessment of the environmental and physiological processes determining the accumulation of organochlorine compounds in European mountain lake fish through multivariate analysis (PCA and PLS)
    M Felipe-Sotelo
    Department of Environmental Chemistry, IIQAB CSIC, C Jordi Girona 18 26, E 08034, Barcelona, Spain
    Sci Total Environ 404:148-61. 2008
    ..PLS models confirmed that temperature and altitude were the main factors influencing the accumulation of most organochlorine compounds in the lipids of the fish tissue...
  100. ncbi Gridded inventories of historical usage for selected organochlorine pesticides in Heilongjiang River Basin, China
    Li yan Liu
    School of Municipal and Environmental Engineering, Harbin Institute of Technology, Harhin, China
    J Environ Sci (China) 18:822-6. 2006
    ..Data of usage and soil concentrations of sigma HCH in HRB match quite well to those in Shanghai region, and much higher soil concentration of sigma DDT in Shanghai region could be due to much heavier dicofol use in this region...
  101. ncbi Organohalogen chemicals in human blood from the United Kingdom
    Gareth O Thomas
    Department of Environmental Sciences, IENS, Lancaster University, Lancaster LA1 4YQ, UK
    Environ Pollut 141:30-41. 2006
    ..There is increasing regulation to control persistent and bioaccumulative chemicals, and establishing human exposure will help to identify substances which should be urgently phased out...

Research Grants62

  1. Prenatal Organochlorine Metabolites, Thyroid Function and Development
    PAM R FACTOR LITVAK; Fiscal Year: 2010
    ..This line of research could lead to prenatal interventions. ..
  2. Effect of exposure to organochlorine compounds on the development of obesity and
    GEORGE E HOWELL; Fiscal Year: 2011
    ..This research will determine if exposure to these compounds is a risk factor for development of T2D and if so will provide mechanisms through which these compounds precipitate this disease. ..
  3. Nonheme Diiron Centers and the Biological Oxidation of Hydrocarbons
    Stephen J Lippard; Fiscal Year: 2013
    ..The ability of these hydrocarbon-consuming "superbugs" to degrade chlorinated hydrocarbons has led to their application in the bioremediation of industrial wastewater, decontamination of seawater, ..
  4. The role of exposure to bioaccumulative organochlorine compounds on the occurrenc
    GEORGE E HOWELL; Fiscal Year: 2010
    ..If so, the present study will provide mechanisms through which these compounds promote this disease and will establish exposure to certain organochlorine compounds as a risk factor for the development of type 2 diabetes. ..
  5. BISPHENOL A LEVELS and ENDOMETRIOSIS RISK IN REPRODUCTIVE-AGE WOMEN
    Victoria L Holt; Fiscal Year: 2012
    ..Because the proposed critical period for exposure to BPA in relation to this disease is during the reproductive years, the findings of this study have the potential for immediate public health impact. ..
  6. Environment, Gene and Testicular Cancer Risk
    Tongzhang Zheng; Fiscal Year: 2010
    ..Another strength is the large sample size, achieved by conducting the study in two states. This will provide the study with sufficient statistical power to test the hypotheses. ..
  7. Interaction of Nutrient & Organochlorine Absorption
    Patrick Tso; Fiscal Year: 2010
    ..The proposed research is important because of the biological and clinical importance of OCs in health and disease and they provide considerable new insights into how OCs are carried and delivered to the various organs in the body. ..
  8. Prenatal Organochlorine Exposure and Male Reproduction
    PAM R FACTOR LITVAK; Fiscal Year: 2010
    ..This study represents the first large systematic evaluation of prenatal exposures to organochlorine compounds and male reproduction and has important implications for basic science, public health and public policy. ..
  9. Low-Cost Electronic Nose for Groundwater Contaminants
    Sanjay Patel; Fiscal Year: 2009
    ..Seacoast's Phase I research will focus on developing the sensor array, demonstrating sensitivity to chlorinated hydrocarbons at relevant concentrations, and field tests in actual contaminated sites...
  10. Elucidating the mechanism of particulate methane monooxygenase
    Megen A Culpepper; Fiscal Year: 2013
    ..According to the Centers of Disease Control, chlorinated hydrocarbons are implicated in endocrine disorders and many forms of cancer...
  11. Low-Cost Electronic Nose for Groundwater Contaminants
    Sanjay V Patel; Fiscal Year: 2012
    ..The proposed work will focus on detection of chlorinated hydrocarbons, which are described as among the most common pollutants in groundwater and soils at DOE sites.
  12. PHYTOESTROGENS, ORGANOCHLORINES, AND FIBROID RISK
    Stephen Schwartz; Fiscal Year: 1999
    ..Phytoestrogen excretion and organochlorine residues in cases and controls will be compared using multivariate unconditional logistic regression models. ..
  13. CHLORINATED HYDROCARBONS EFFECTS ON MAMMALIAN SYSTEMS
    David Kupfer; Fiscal Year: 2003
    ..CYP3A4 catalyzes the metabolism of the majority of drugs and is involved in drug-drug interaction. Understanding the mechanism of 3A4 activity would be useful in predicting drug interactions and drug:drug-metabolite interactions. ..
  14. ORGANOCHLORINE COMPOUNDS AND RISK OF BREAST CANCER
    Tongzhang Zheng; Fiscal Year: 1993
    ..Statistical analyses will be performed using standard multivariable techniques to address the study hypotheses and to control for confounding...
  15. NITRIC OXIDE, NEUROPEPTIDES, AND OVULATION
    Satya Kalra; Fiscal Year: 2000
    ..Environmental estrogens and estrogen-like pollutants (pesticides, chlorinated hydrocarbons, the breakdown products of plastics) as well as improper levels of NO are also known to produce ..
  16. Sub-micrometer zero valent metal for in-situ remediation of contaminated aquifers
    JOHN FREIM; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): In prior decades, chlorinated hydrocarbons were used for cleaning and degreasing...
  17. ORGANOCHLORINE COMPOUNDS AND MENSTRUAL CYCLE FUNCTION
    Gayle Windham; Fiscal Year: 1999
    ..g. cycle length) and dichotomous "abnormalities" (e.g. short luteal phase or anovulation). If interesting associations are revealed, follow-up in larger populations, with a larger gradient of exposure, will be warranted. ..
  18. Effects of organochlorines on male infertility
    JULIA WIRTH; Fiscal Year: 2006
    ..abstract_text> ..
  19. Feto-Maternal Pharmacokinetics of Abused Inhalants
    STEPHEN DEWEY; Fiscal Year: 2004
    ..indicate that 10% of an inhaled dose of toluene reaches the fetus whereas this fraction is 2% -4% for chlorinated hydrocarbons or for more highly substituted aromatics such as xylene and styrene...
  20. In Utero Organochlorine Exposure & Breast Density
    BARBARA COHN; Fiscal Year: 2009
    ..These women have not yet achieved the age of high breast cancer risk. The proposed project is an efficient use of existing resources for a unique 40-year follow-up study. ..
  21. FEASIBILITY OF MODELING REACTIONS IN ENZYME ACTIVE SITES
    JAMES DIX; Fiscal Year: 1999
    b>Chlorinated hydrocarbons constitute the largest class of toxic chemicals in EPA Superfund sites...
  22. Exposure to Organochlorines, EBV, and the Risk of NHL
    Francine Laden; Fiscal Year: 2006
    ..abstract_text> ..
  23. EMF AND BREAST CANCER ON LONG ISLAND
    M Leske; Fiscal Year: 2000
    ..It is hoped that this study will help to clarify the reasons for the high breast cancer incidence on Long Island. ..
  24. EMF, OCPS, AND BREAST CANCER ON LONG ISLAND, NY
    Lee Caplan; Fiscal Year: 1993
    ..It is hoped that this study will help to clarify the reasons for the high breast cancer incidence on Long Island...
  25. BREAST CANCER AND THE ENVIRONMENT ON LONG ISLAND
    Marilie Gammon; Fiscal Year: 2004
    ..Potential subgroup effects, with cases partitioned on p53 and HER-2/neu expression, the relation between environmental factors on breast cancer survival will be explored, where possible. ..
  26. MECHANISM OF ESTROGENICITY OF DDT ANALOGS IN MCG-7 CELLS
    Fumio Matsumura; Fiscal Year: 2001
    ..The PI finally will address the fundamental question of whether c-Neu activation serves as a major gateway in addition to the estrogen receptor for xenobiotics to cause truly estrogenic cellular responses or not. ..
  27. Prenatal organochlorines, thyroid, and development
    Pam Factor Litvak; Fiscal Year: 2006
    ..This line of research could lead to prenatal interventions. ..
  28. NERVOUS SYSTEM PORPHYRINS AND LEAD AND PCB EFFECTS
    William Whetsell; Fiscal Year: 1980
    ..This pathway is subject to inhbition by lead and by high levels of chlorinated hydrocarbons. Our further studies have suggested that the inhibition by lead can be circumvented by supplying ..
  29. Action of Novel Anti-tumor Agents on Cell Communication
    Diane Matesic; Fiscal Year: 2005
    ..abstract_text> ..
  30. MECHANISMS FOR TNF ALPHA IN XENOBIOTIC LIVER INJURY
    Mark Rutherford; Fiscal Year: 2000
    ..Liver histopathology will be evaluated in TNFR deficient mice exposed to CCl4 acetaminophen, cadmium, and chlorinated hydrocarbons to determine whether neutralization of specific TNF-a signals impacts tissue damage and gene expression ..
  31. ENVIRONMENTAL RISK FACTORS AND BREAST CANCER IN MARYLAND
    Kathy Helzlsouer; Fiscal Year: 1993
    ....
  32. Novel Catalysts for Photocatalytic AIR Emissions Control
    JAMES KITTRELL; Fiscal Year: 2003
    ..photocatalysts and reactor systems for an Adsorption-Integrated-Reaction (AIR) technology, to destroy chlorinated hydrocarbons with high activity and with very high selectivity. KSE, Inc...
  33. GABAERGIC INSECTICIDE TOXICOLOGY
    JOHN CASIDA; Fiscal Year: 2002
    ....
  34. ALKYL PCDFS--INHIBITION OF MAMMARY CANCER
    Stephen Safe; Fiscal Year: 2001
    ..Thus the proposed studies will define a new mechanism-based class of antiestrogens that can be used alone or in combination with tamoxifen for treatment of breast and endometrial cancer. ..
  35. Evolution of Estrogen Receptor-Ligand Interactions
    Jennifer Fox; Fiscal Year: 2006
    ..Such an experimental system will allow the rigorous testing of hypotheses about ER-ligand structure function relationships and the dynamics of receptor-ligand coevolution. ..
  36. Meningioma: Risk Factors and Quality of Life
    Joellen M Schildkraut; Fiscal Year: 2010
    ..This study represents the first concentrated effort to examine environmental and genetic risk factors for meningioma. ..
  37. Effects of Long-Term Low Level Hydrogen Sulfide Exposure
    Michael N Bates; Fiscal Year: 2010
    ..Study results will either confirm the adequacy of current U.S. occupational and environmental exposure standards for H2S or provide evidence that they are insufficiently health protective. ..
  38. Wearable Organic Electric Film RFID Sensors for Monitoring of Airborne Toxicants
    Radislav A Potyrailo; Fiscal Year: 2010
    ..This new sensing approach will provide a wearable, cost-effective, selective sensor for de- tection of toxic volatile species. ..
  39. CAROLINA AND GEORGIA GENETICS NETWORK CENTER
    Joellen Schildkraut; Fiscal Year: 2004
    ..Within this application, we propose to take advantage of our expertise and resources to ascertain registrants by augmenting referral services and by piloting the selective use of our unique registries. ..
  40. Risk Factors for Ductal Carcinoma In Situ (DCIS)
    Julia Brody; Fiscal Year: 2004
    ..The study builds on the Cape Cod Breast Cancer and Environment Study of invasive breast cancer and additional grants that currently support the proposed study of DCIS. ..
  41. Building Food Justice in East New York
    Kimberly Morland; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  42. TOXICOLOGY OF ENVIRONMENT CONTAMINANTS
    Stephen Safe; Fiscal Year: 2007
    ..The proposed training program will continue to provide trainees with a challenging academic and research environment that will prepare them for future careers in academic, industry and government. ..
  43. Impact of Environmental Pollutants on Breast Cancer and*
    Julia Brody; Fiscal Year: 2005
    ..abstract_text> ..
  44. Organophosphorus Pesticide Toxicology
    JOHN CASIDA; Fiscal Year: 2006
    ..Knowledge gained on OP pesticide toxicology is also applicable to OP nerve gases as chemical warfare and terrorism agents. ..
  45. Reducing pesticide exposures to farmworker children.
    Brenda Eskenazi; Fiscal Year: 2005
    ....
  46. Mechanisms of Growth Factor-Estrogen Receptor Crosstalk
    Stephen Safe; Fiscal Year: 2006
    ..abstract_text> ..
  47. Dermatopharmacokinetics: In Vivo Analysis of Solvents
    Karla Thrall; Fiscal Year: 2005
    ..To evaluate the kinetics and dermal bioavailability of ethylbenzene, styrene, and toluene vapor using F344 rats. ..
  48. 2006 Drinking Water Disinection By-Product (DBP) Gordon Conference
    Susan Richardson; Fiscal Year: 2006
    ..Issues to be covered include new reproductive/developmental toxicological issues, human exposure, chemistry of formation, and remaining cancer issues. [unreadable] [unreadable] [unreadable] [unreadable]..
  49. PHYSIOLOGICALLY ACTIVE NATURAL PRODUCTS
    Douglass Taber; Fiscal Year: 2007
    ..In the course of these investigations, new molecular reactivity will be developed that will substantially shorten current routes to polycyclic natural products and drug candidates. ..
  50. Inhibins and Environmental Estrogens in Ovarian Disease
    Louis Guillette; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  51. Cardiovascular Consequences of Thyroid Dysfunction
    Elizabeth Pearce; Fiscal Year: 2007
    ..Pearce's career as an independent academic clinical investigator with a focus on thyroid disease and epidemiology. ..
  52. Columbia-GHI Consortium for Claims-Based Cancer Studies
    STEVEN STELLMAN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  53. NEW BIOMARKERS OF NEUROTOXICITY
    Marc Weisskopf; Fiscal Year: 2008
    ..abstract_text> ..
  54. MOHAWK CULTURE, BEHAVIOR, TOXICANT EXPOSURE AND HEALTH
    LAWRENCE SCHELL; Fiscal Year: 2004
    ..abstract_text> ..
  55. Genetic damage in the sperm and blood of workers exposed to benzene
    Brenda Eskenazi; Fiscal Year: 2008
    ..Lastly, this study is one of the first to investigate the relative sensitivities of sperm and blood cells to chromosomal defects induced by benzene. [unreadable] [unreadable] [unreadable]..
  56. Inhibition of Pancreatic Cancer by New PPARgamma Agonis*
    Stephen Safe; Fiscal Year: 2008
    ..PPAR? -active C-substituted DIMs that inhibit pancreatic cancer cell growth in vitro and in vivo, and these will serve as lead compounds for development of new drugs for clinical treatment of this devastating disease ..