halogenated hydrocarbons

Summary

Top Publications

  1. ncbi Plasma levels of persistent organohalogens and hormone levels in adult male humans
    L Hagmar
    Department of Occupational and Environmental Medicine, University Hospital, Lund, Sweden
    Arch Environ Health 56:138-43. 2001
  2. ncbi In vitro assessment of the effect of halogenated hydrocarbons: chloroform, dichloromethane, and dibromoethane on embryonic development of the rat
    P D Brown-Woodman
    Department of Biochemical Sciences, Faculty of Health Sciences, University of Sydney, Lidcombe, N S W, Australia
    Teratology 57:321-33. 1998
  3. ncbi Fast-track DRESSA: a bioassay for fast, sensitive, and selective detection of halogenated and polycyclic aromatic hydrocarbons
    Ayumi Kasai
    Department of Biochemistry, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Tamaho, Yamanashi 409 3898, Japan
    Anal Biochem 337:84-8. 2005
  4. ncbi Persistent halogenated hydrocarbons in consumer fish of China: regional and global implications for human exposure
    Xiang Zhou Meng
    State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China
    Environ Sci Technol 41:1821-7. 2007
  5. ncbi Histology of selected immunological organs in polar bear (Ursus maritimus) from East Greenland in relation to concentrations of organohalogen contaminants
    M Kirkegaard
    Department of Arctic Environment, National Environmental Research Institute, Frederiksborgvej 399, 4000 Denmark
    Sci Total Environ 341:119-32. 2005
  6. ncbi Zinc trimethylsilylamide as a mild ammonia equivalent and base for the amination of aryl halides and triflates
    Dae Yon Lee
    Department of Chemistry, Yale University, P O Box 208107, New Haven, Connecticut 6520 8107, USA
    Org Lett 7:1169-72. 2005
  7. ncbi Palladium(0)-catalyzed tandem cyclization of allenenes: direct construction of tricyclic heterocycles through aromatic C--H activation
    Hiroaki Ohno
    Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan
    Chemistry 11:3728-41. 2005
  8. doi Palladium-catalyzed carbene insertion and trapping with carbon nucleophiles
    Sean K J Devine
    Department of Chemistry, 1102 Natural Sciences, University of California, Irvine, California 92697 2025, USA
    Org Lett 10:1909-11. 2008
  9. ncbi Convergent synthesis of polyhalogenated quinoline C-nucleosides as potential antiviral agents
    Jiong J Chen
    Department of Chemistry, College of Literature, Sciences and Arts, University of Michigan, Ann Arbor 48109 1065, USA
    J Org Chem 68:4170-8. 2003
  10. doi Site-selective sp2 and benzylic sp3 palladium-catalyzed direct arylation
    Louis Charles Campeau
    Center for Catalysis Research and Innovation, University of Ottawa, Department of Chemistry, 10 Marie Curie, Ottawa, Ontario, Canada K1N 6N5
    J Am Chem Soc 130:3266-7. 2008

Detail Information

Publications198 found, 100 shown here

  1. ncbi Plasma levels of persistent organohalogens and hormone levels in adult male humans
    L Hagmar
    Department of Occupational and Environmental Medicine, University Hospital, Lund, Sweden
    Arch Environ Health 56:138-43. 2001
    ..High consumption of organohalogen-polluted fish did not appear to affect plasma concentrations of pituitary, thyroid, or testosterone hormone levels in male adults...
  2. ncbi In vitro assessment of the effect of halogenated hydrocarbons: chloroform, dichloromethane, and dibromoethane on embryonic development of the rat
    P D Brown-Woodman
    Department of Biochemical Sciences, Faculty of Health Sciences, University of Sydney, Lidcombe, N S W, Australia
    Teratology 57:321-33. 1998
    b>Halogenated hydrocarbons are widely used in industry, the laboratory, and in the home...
  3. ncbi Fast-track DRESSA: a bioassay for fast, sensitive, and selective detection of halogenated and polycyclic aromatic hydrocarbons
    Ayumi Kasai
    Department of Biochemistry, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Tamaho, Yamanashi 409 3898, Japan
    Anal Biochem 337:84-8. 2005
    ..Because of its time-saving property and easiness, sensitiveness, and specificity, the fast-track DRESSA would be advantageous for high-throughput screening of dioxin and dioxin-like compounds in environmental samples...
  4. ncbi Persistent halogenated hydrocarbons in consumer fish of China: regional and global implications for human exposure
    Xiang Zhou Meng
    State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China
    Environ Sci Technol 41:1821-7. 2007
    Concentrations of persistent halogenated hydrocarbons (PHHs) were determined in 13 consumer fish species (a total of 390 individuals) collected from a major fish-farming region of China...
  5. ncbi Histology of selected immunological organs in polar bear (Ursus maritimus) from East Greenland in relation to concentrations of organohalogen contaminants
    M Kirkegaard
    Department of Arctic Environment, National Environmental Research Institute, Frederiksborgvej 399, 4000 Denmark
    Sci Total Environ 341:119-32. 2005
    ....
  6. ncbi Zinc trimethylsilylamide as a mild ammonia equivalent and base for the amination of aryl halides and triflates
    Dae Yon Lee
    Department of Chemistry, Yale University, P O Box 208107, New Haven, Connecticut 6520 8107, USA
    Org Lett 7:1169-72. 2005
    ..In addition, aryl bromides coupled with aryl and alkylamines with the combination of Zn[N(SiMe(3))(2)](2) and LiCl as base. These aminations occurred without racemization of the enolizable stereocenter of an optically active ester...
  7. ncbi Palladium(0)-catalyzed tandem cyclization of allenenes: direct construction of tricyclic heterocycles through aromatic C--H activation
    Hiroaki Ohno
    Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan
    Chemistry 11:3728-41. 2005
    ..The reaction with heterocyclic aryl halides such as iodopyrazine or 4-bromo-1-methylindole afforded tri- or tetracyclic heteroaromatic products in good yields...
  8. doi Palladium-catalyzed carbene insertion and trapping with carbon nucleophiles
    Sean K J Devine
    Department of Chemistry, 1102 Natural Sciences, University of California, Irvine, California 92697 2025, USA
    Org Lett 10:1909-11. 2008
    ..The allylpalladium intermediate is attacked by the carbon nucleophile to generate a vinylsilane product...
  9. ncbi Convergent synthesis of polyhalogenated quinoline C-nucleosides as potential antiviral agents
    Jiong J Chen
    Department of Chemistry, College of Literature, Sciences and Arts, University of Michigan, Ann Arbor 48109 1065, USA
    J Org Chem 68:4170-8. 2003
    ..The 2-aminophenone alpha-nucleoside (11) was successfully anomerized to the beta-anomer (19), which led to the synthesis of the targeted 2-chloro- and 2-bromo-6,7-dichloro-4-(beta-d-ribofuranosyl)quinolines (18and 21, respectively)...
  10. doi Site-selective sp2 and benzylic sp3 palladium-catalyzed direct arylation
    Louis Charles Campeau
    Center for Catalysis Research and Innovation, University of Ottawa, Department of Chemistry, 10 Marie Curie, Ottawa, Ontario, Canada K1N 6N5
    J Am Chem Soc 130:3266-7. 2008
  11. ncbi C-C bond formation catalyzed heterogeneously by nickel-on-graphite (Ni/Cg)
    Bruce H Lipshutz
    Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA
    Org Lett 10:697-700. 2008
    ..Comparisons are made with the charcoal analogue, Ni/C, and some unusual chemoselectivities between these catalysts have been uncovered...
  12. ncbi Ionic liquid as reagent. A green procedure for the regioselective conversion of epoxides to vicinal-halohydrins using [AcMIm]X under catalyst- and solvent-free conditions
    Brindaban C Ranu
    Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 032, India
    J Org Chem 70:4517-9. 2005
    ..The cleavages are considerably fast and highly regioselective...
  13. ncbi Reductive coupling of terpenic allylic halides catalyzed by Cp2TiCl: a short and efficient asymmetric synthesis of onocerane triterpenes
    Alejandro F Barrero
    Department of Organic Chemistry, Institute of Biotechnology, University of Granada, Avenida Fuentenueva, 18071 Granada, Spain
    Org Lett 7:2301-4. 2005
    ..This process has been employed in the short and effective synthesis of terpenoids such as beta-onoceradiene (1), beta-onocerin (2), and squalene (3). Evidence is presented for eta1-allyltitanium species being involved in the coupling...
  14. ncbi Omega-halonitriles: domino cyclizations to oxa- and carbocyclic nitriles
    Fraser F Fleming
    Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, Pennsylvania 15282 1530, USA
    J Org Chem 68:3943-6. 2003
    ..Collectively these cyclizations provide rapid assembly of five- and six-membered oxa- and carbocyclic nitriles demonstrating the utility of omega-halonitriles in domino alkylations...
  15. ncbi Microwave-promoted Heck coupling using ultralow metal catalyst concentrations
    Riina K Arvela
    Department of Chemistry, University of Connecticut, Unit 3060, 55 North Eagleville Road, Storrs, Connecticut 06269 3060, USA
    J Org Chem 70:1786-90. 2005
    ..We show that Heck couplings can be performed in water using microwave heating and Pd catalyst concentrations as low as 500 ppb. The methodology is simple; all that is required as the catalyst is a stock solution of palladium...
  16. doi Enantioselective alkyl-alkyl Suzuki cross-couplings of unactivated homobenzylic halides
    Bunnai Saito
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 130:6694-5. 2008
    ..To the best of our knowledge, there are no previous examples of enantioselective Suzuki couplings of alkyl electrophiles (activated or unactivated). Both of the catalyst components are commercially available...
  17. ncbi Isolation of halogenated monoterpenes from bioreactor-cultured microplantlets of the macrophytic red algae Ochtodes secundiramea and Portieria hornemannii
    Luis F Barahona
    CICY Biotecnologia, Apartado Postal 87, 97310 Cordemex, Merida, Mexico
    J Nat Prod 66:743-51. 2003
    ..This study demonstrated that bioreactor tissue culture is a new venue for bioprospecting and production of natural compounds from marine macroalgae under a controlled environment...
  18. ncbi Homogeneous catalysts supported on soluble polymers: biphasic Suzuki-Miyaura coupling of aryl chlorides using phase-tagged palladium-phosphine catalysts
    Markus an der Heiden
    Institut fur Anorganische Chemie, Petersenstrasse 18, TU Darmstadt, 64287 Darmstadt, Germany
    Chemistry 10:1789-97. 2004
    ..There is no apparent leaching of the catalyst into the heptane solution (<0.05 %), as evidenced by spectrophotometric measurements, and contamination of the product with Pd is avoided...
  19. ncbi Palladium-catalyzed arylation of trimethylsilyl enolates of esters and imides. High functional group tolerance and stereoselective synthesis of alpha-aryl carboxylic acid derivatives
    Xiaoxiang Liu
    Department of Chemistry, Yale University, New Haven, Connecticut 06510 USA
    J Am Chem Soc 126:5182-91. 2004
    ..Mechanistic studies showed that the reaction conditions are neutral enough that the observed diastereomeric ratios reflect kinetic selectivities...
  20. ncbi Nickel-catalyzed cross-couplings of organosilicon reagents with unactivated secondary alkyl bromides
    David A Powell
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 126:7788-9. 2004
    ..Noteworthy attributes of the method are its scope (secondary electrophiles), its high functional-group compatibility, and the air stability of the catalyst components...
  21. ncbi The mechanisms of the Stille reaction
    Pablo Espinet
    Quimica Inorganica, Facultad de Ciencias, Universidad de Valladolid, 47005, Spain
    Angew Chem Int Ed Engl 43:4704-34. 2004
    ..The purpose of this Review is to give a critical account of this progress...
  22. pmc Orthogonal Pd- and Cu-based catalyst systems for C- and N-arylation of oxindoles
    Ryan A Altman
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 130:9613-20. 2008
    ..Computational examination of the relevant L1Pd(Ar)(oxindolate) and diamine-Cu(oxindolate) species was performed to gain mechanistic insight into the controlling features of the observed chemoselectivity...
  23. ncbi Ring expansion-annulation strategy for the synthesis of substituted azulenes and oligoazulenes. 2. Synthesis of azulenyl halides, sulfonates, and azulenylmetal compounds and their application in transition-metal-mediated coupling reactions
    Aimee L Crombie
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Org Chem 69:8652-67. 2004
    ..The application of these coupling reactions to the synthesis of biazulenes, terazulene 101, and related oligoazulenes is described, as well as the preparation of the azulenyl amino acid derivative 110...
  24. ncbi Introduction of a third meso substituent into 5,10-diaryl chlorins and oxochlorins
    Masahiko Taniguchi
    Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695 8204, USA
    J Org Chem 70:275-85. 2005
    ..This study provides access to new chlorins/oxochlorins that can be utilized in diverse applications...
  25. ncbi Preferential oxidative addition in palladium(0)-catalyzed suzuki cross-coupling reactions of dihaloarenes with arylboronic acids
    Cheng Guo Dong
    Department of Chemistry, College of Staten Island and the Graduate Center of the City University of New York, Staten Island, New York 10314, USA
    J Am Chem Soc 127:10006-7. 2005
    ..The results described here may lead to the development of new, efficient processes to conjugate polymers with controlled length which are potentially useful in molecular electronics...
  26. ncbi Efficient pd-catalyzed amination of heteroaryl halides
    Mark D Charles
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Org Lett 7:3965-8. 2005
    ..In particular, we report the first couplings of amines with chloro- and bromoindoles bearing a free NH, as well as the first Pd-catalyzed aminations of a 5-halopyrimidine. [reaction: see text]..
  27. ncbi A soluble base for the copper-catalyzed imidazole N-arylations with aryl halides
    Longbin Liu
    Chemical Research and Discovery, Amgen Inc, One Amgen Center Drive, Thousand Oaks, California 91320, USA
    J Org Chem 70:10135-8. 2005
    ..Preliminary results with aryl chlorides are also reported...
  28. ncbi Simple copper salt-catalyzed N-arylation of nitrogen-containing heterocycles with aryl and heteroaryl halides
    Liangbo Zhu
    Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, West China Hospital, Sichuan University, Chengdu 610064, PR China
    J Org Chem 72:8535-8. 2007
    ..with aryl and heteroaryl halides have been developed. The protocols can be performed easily and tolerate a number of functional groups, such as ester, nitrile, nitro, ketone, free hydroxyl, and free primary amine on the aryl halide...
  29. ncbi Direct arylation of thiazoles on water
    Gemma L Turner
    School of Chemistry, University of Edinburgh, King s Buildings, West Mains Rd, Edinburgh, UK
    Angew Chem Int Ed Engl 46:7996-8000. 2007
  30. ncbi Pd-mBDPP-catalyzed regioselective internal arylation of electron-rich olefins by aryl halides
    Shifang Liu
    Department of Chemistry, Liverpool Centre for Materials and Catalysis, University of Liverpool, Liverpool L697ZD, UK
    J Org Chem 71:7467-70. 2006
    ..The better performance of mBDPP, compared with that of the commonly used DPPP [1,3-bis(diphenylphosphino)propane], highlights the important but subtle effect of ligand on the regioselectivity of the Heck arylation reactions...
  31. pmc Pd(OAc)(2)-catalyzed Domino reactions of 1-chloro-2-haloarenes and 2-haloaryl tosylates with hindered Grignard reagents via palladium-associated arynes
    Cheng Guo Dong
    Department of Chemistry, College of Staten Island and the Graduate Center of the City University of New York, Staten Island, NY 10314, USA
    Org Lett 8:5057-60. 2006
    ..reaction: see text]..
  32. ncbi Palladium-catalyzed cross-coupling between vinyl halides and tert-butyl carbazate: first general synthesis of the unusual N-Boc-N-alkenylhydrazines
    José Barluenga
    Instituto Universitario de Quimica Organometalica Enrique Moles, Universidad de Oviedo, Julian Claveria 8, Oviedo 33006, Spain
    Org Lett 9:275-8. 2007
    ..The present methodology represents the first general way to access this highly functionalized and unusual type of hydrazines. [reaction: see text]...
  33. ncbi Regioselective (site-selective) functionalization of unsaturated halogenated nitrogen, oxygen and sulfur heterocycles by Pd-catalysed cross-couplings and direct arylation processes
    Ian J S Fairlamb
    Department of Chemistry, University of York, Heslington, York, UK
    Chem Soc Rev 36:1036-45. 2007
    ..Direct arylation of electron-rich unsaturated heterocyclic compounds by C-H functionalization is also presented...
  34. ncbi Regioselective synthesis of 1-alkyl- or 1-aryl-1H-indazoles via copper-catalyzed cyclizations of 2-haloarylcarbonylic compounds
    Dolores Viña
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, CIETUS, Campus Unamuno, 37007 Salamanca, Spain
    Org Lett 9:525-8. 2007
    ..Ligands commonly employed as catalysts for intermolecular amination were shown to be ineffective for this cyclization...
  35. ncbi Synthesis of tricyclic heterocycles via a tandem aryl alkylation/heck coupling sequence
    Dino Alberico
    Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St George Street, Toronto, Ontario, M5S 3H6, Canada
    J Org Chem 72:775-81. 2007
    ..This approach was further applied to the synthesis of a tricyclic mescaline analogue...
  36. ncbi Palladium-catalyzed direct arylation of aryl(azaaryl)methanes with aryl halides providing triarylmethanes
    Takashi Niwa
    Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto Daigaku Katsura, Nishikyo ku, Kyoto 615 8510, Japan
    Org Lett 9:2373-5. 2007
    ..Direct arylation of aryl(azaaryl)methanes with aryl halides takes place at the benzylic position in the presence of a hydroxide base under palladium catalysis to yield triarylmethanes...
  37. ncbi Phosphine-free cross-coupling reaction of arylboronic acids with carboxylic anhydrides or acyl chlorides in aqueous media
    Bingwei Xin
    Department of Chemistry, Zhejiang University, Hangzhou 310027, P R China
    J Org Chem 71:5725-31. 2006
    ..The Pd(OAc)2-H2O-[bmim][PF6] catalytic system can be recovered and reused eight times with high efficiency for both carboxylic anhydride and acyl chloride...
  38. ncbi Diversity synthesis using the complimentary reactivity of rhodium(II)- and palladium(II)-catalyzed reactions
    Aiwu Ni
    Department of Chemistry, University at Buffalo, State University of New York, Buffalo, New York 14260, USA
    J Org Chem 71:5594-8. 2006
    ..The combination of the rhodium(II)-catalyzed reaction with a subsequent palladium(II)-catalyzed Suzuki coupling offers a novel strategy for diversity synthesis...
  39. doi Palladium nanoclusters supported on propylurea-modified siliceous mesocellular foam for coupling and hydrogenation reactions
    Nandanan Erathodiyil
    Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Singapore
    Chemistry 14:3118-25. 2008
    ..This immobilized catalyst allows for ease of recovery/reuse and minimization of waste generation, which are of great interest in the development of green chemical processes...
  40. doi Differentially protected benzenediboronic acids: divalent cross-coupling modules for the efficient synthesis of boron-substituted oligoarenes
    Hiroyoshi Noguchi
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Kyoto 615 8510, Japan
    Org Lett 10:377-80. 2008
    ....
  41. ncbi Efficient synthesis of sterically crowded biaryls by palladium-phosphinous acid-catalyzed cross-coupling of aryl halides and aryl grignards
    Christian Wolf
    Department of Chemistry, Georgetown University, Washington, DC 20057, USA
    J Org Chem 73:162-7. 2008
    ..The reaction also proceeds with aryl iodides at -20 degrees C, and under these conditions, functional groups that are generally not compatible with Grignard reagents are tolerated...
  42. ncbi An improved Cu-based catalyst system for the reactions of alcohols with aryl halides
    Ryan A Altman
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Org Chem 73:284-6. 2008
    ..The relatively mild conditions, short reaction times, and moderately low catalyst loading allow for a wide array of functional groups to be tolerated on both the electrophilic and nucleophilic coupling partners...
  43. ncbi Reevaluation of the mechanism of the amination of aryl halides catalyzed by BINAP-ligated palladium complexes
    Shashank Shekhar
    Department of Chemistry, Yale University, P O Box 208107, New Haven, Connecticut 06520 8107, USA
    J Am Chem Soc 128:3584-91. 2006
    ..By this mechanism, the amine and base react with [Pd(BINAP)(Ar)(Br)] to form an arylpalladium amido complex, and reductive elimination from this amido complex forms the arylamine...
  44. ncbi Facile access to polysubstituted indoles via a cascade Cu-catalyzed arylation-condensation process
    Yu Chen
    Department of Chemistry, Fudan University, Shanghai, China
    J Org Chem 72:9329-34. 2007
    ..Polysubstituted indoles can be prepared from substituted 2-halotrifluoroacetanilides with high regioselectivity...
  45. ncbi Pd-catalyzed ring opening of oxa- and azabicyclic alkenes with aryl and vinyl halides: efficient entry to 2-substituted 1,2-dihydro-1-naphthols and 2-substituted 1-naphthols
    Chi Li Chen
    Department of Chemistry and Biochemistry, University of Texas, Austin, Texas 78712, USA
    J Org Chem 71:4810-7. 2006
    ..Oxidation of the intermediate 1,2-dihydro-1-naphthols using IBX yielded the corresponding 2-substituted 1-naphthols in good to excellent yields...
  46. ncbi Proline/pipecolinic acid-promoted copper-catalyzed P-arylation
    Cheng Huang
    Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, PR China
    J Org Chem 71:5020-2. 2006
    ....
  47. ncbi Highly selective room-temperature copper-catalyzed C-N coupling reactions
    Alexandr Shafir
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 128:8742-3. 2006
    ..The high selectivity of the CuI-beta-diketone catalyst for aliphatic amines represents a useful complement to the palladium-based methods...
  48. ncbi Heterogeneous Pd/C-catalyzed ligand-free, room-temperature Suzuki-Miyaura coupling reactions in aqueous media
    Tomohiro Maegawa
    Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, Mitahora Higashi, Gifu 502 8585, Japan
    Chemistry 13:5937-43. 2007
    ....
  49. ncbi Halo-enediynes: probing the electronic and stereoelectronic contributions to the Bergman cycloaromatization
    Gary W Plourde
    Department of Chemistry, Northeastern University, Boston, Massachusetts 02115, USA
    J Org Chem 67:5369-74. 2002
    ..In all cases studied the halogen atom had a strongly retardative effect on the thermal Bergman cycloaromatization reaction. The isolation of the first C-9 monochloroenediyne is noteworthy, and may find application in prodrug design...
  50. ncbi Iron-catalyzed alkylations of aromatic grignard reagents
    Gérard Cahiez
    Laboratoire de Synthèse Organique Sélective et de Chimie Organométallique SOSCO, UMR 8123 CNRS UCP ESCOM, 5 Mail Gay Lussac, Neuville s Oise, 95092 Cergy Pontoise, France
    Angew Chem Int Ed Engl 46:4364-6. 2007
  51. ncbi New Heck-type reaction applied to the synthesis of protoporphyrin-IX derivatives
    M Castella
    , Universitat de Barcelona, , E-08028 Barcelona, Catalunya, Spain
    Org Lett 3:541-4. 2001
    ..This coupling reaction, although providing moderate regioselectivity, gives quantitative conversion...
  52. ncbi An annulative approach to highly substituted indoles: unusual effect of phenolic additives on the success of the arylation of ketone enolates
    Jennifer L Rutherford
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 124:15168-9. 2002
    ..The products of this reaction were then readily reductively cyclized to give highly substituted indoles in moderate to excellent overall yields...
  53. ncbi Scope and mechanism of palladium-catalyzed amination of five-membered heterocyclic halides
    Mark W Hooper
    Department of Chemistry, P O Box 208107, Yale University, New Haven, Connecticut 06520 8107, USA
    J Org Chem 68:2861-73. 2003
    ..The fastest aminations of thiazoles, benzimidazoles, and benzoxazoles occurred with the combination of palladium trifluoroacetate and P(t)Bu(3) as catalyst...
  54. ncbi Pd-catalyzed intermolecular amidation of aryl halides: the discovery that xantphos can be trans-chelating in a palladium complex
    Jingjun Yin
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 124:6043-8. 2002
    ..X-ray crystallographic analysis of II revealed a rare trans-chelating bisphosphine-Pd(II) structure with a large bite angle of 150.7 degrees...
  55. ncbi Multifunctional palladium catalysis. 2. Tandem haloallylation followed by Wacker-Tsuji oxidation or sonogashira cross-coupling
    Avinash N Thadani
    Department of Chemistry, The University of Chicago, 5735 South Ellis Avenue, Chicago, Illinois 60637, USA
    Org Lett 4:4321-3. 2002
    ..The homogeneous palladium dihalide catalyst utilized for the bromo-/chloroallylation of alkynes is reused in situ for subsequent Wacker-Tsuji oxidation or Sonogashira cross-coupling...
  56. ncbi Synthesis of n-heteroaryl-7-azabicyclo[2.2.1]heptane derivatives via palladium-bisimidazol-2-ylidene complex catalyzed amination reactions
    J Cheng
    Department of Chemistry, University of New Orleans, New Orleans, Louisiana 70148, USA
    Org Lett 3:1371-4. 2001
    ..2.1]heptane has been achieved. The cross-coupling amination reaction employs palladium-bisimidazol-2-ylidene complexes as catalysts to give good to moderate yields over a wide variety of substrates...
  57. ncbi Isolation, structure determination, and biological activity of a novel alkaloid, perophoramidine, from the Philippine ascidian Perophora namei
    Sheryl M Verbitski
    Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    J Org Chem 67:7124-6. 2002
    ..The structure of 1 was determined by the interpretation of 1D/2D NMR and MS data. Dehalogenation of perophoramidine (1) by ammonium formate catalyzed transfer hydrogenation confirmed the type and number of halogen atoms present in 1...
  58. ncbi Palladium-catalyzed hydrocarbonation and hydroamination of 3,3-dihexylcyclopropene with pronucleophiles
    Itaru Nakamura
    Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980 8578, Japan
    J Org Chem 68:2297-9. 2003
    ....
  59. ncbi Efficient synthesis of alpha-aryl esters by room-temperature palladium-catalyzed coupling of aryl halides with ester enolates
    Morten Jørgensen
    Department of Chemistry, Yale University, P O Box 208107, New Haven, Connecticut 06520 8107, USA
    J Am Chem Soc 124:12557-65. 2002
    ....
  60. ncbi C10-substituted camphors and fenchones by electrophilic treatment of 2-methylenenorbornan-1-ols: enantiospecificity, scope, and limitations
    Santiago de la Moya Cerero
    Departamento de Quimica Organica I, Facultad de Ciencias Quimicas, Universidad Complutense de Madrid, Ciudad Universitaria, 28040 Madrid, Spain
    J Org Chem 68:1451-8. 2003
    ..The feasibility of the described methodology has been exemplified by the highly efficient enantiospecific preparation of several interesting C(10)-halogen-, C(10)-O-, C(10)-S-, C(10)-Se-, or C(10)-C-substituted camphors and fenchones...
  61. ncbi Palladium-catalyzed arylation of malonates and cyanoesters using sterically hindered trialkyl- and ferrocenyldialkylphosphine ligands
    Neil A Beare
    Department of Chemistry, Yale University, P O Box 208107, New Haven, Connecticut 06520 8107, USA
    J Org Chem 67:541-55. 2002
    ....
  62. ncbi Comparative toxicity of polychlorinated biphenyls to Japanese quail (Coturnix c. japonica) and American kestrels (Falco sparverius)
    J E Elliott
    Canadian Wildlife Service, Environment Canada, National Wildlife Research Centre, Ottawa, Ontario, Canada
    J Toxicol Environ Health 51:57-75. 1997
    Polychlorinated biphenyls (PCBs) and related halogenated hydrocarbons bioaccumulate to high concentrations in top predators, such as raptorial birds, yet little is known of PCB toxicity to such species...
  63. ncbi Characterization of hydrocarbons, halocarbons and carbonyls in the atmosphere of Hong Kong
    H Guo
    Research Centre for Urban Environmental Technology and Management, Department of Civil and Structural Engineering, The Hong Kong Polytechnic University, Hung Hom Kowloon, Hong Kong
    Chemosphere 57:1363-72. 2004
    ..The BTEX ratios at CW and TW were 1.6:10.1:1.0:1.6 and 2.1:10.8:1.0:2.0, respectively. For major halogenated hydrocarbons, the mean concentrations of chloromethane, CFCs 12 and 22 did not show spatial variations at the two ..
  64. ncbi Volatile substance and other drug abuse inhalation in Spain
    María Fátima Ramón
    Servicio de Información Toxicológia, Instituto Nacional de Toxicologia, Madrid, Spain
    J Toxicol Clin Toxicol 41:931-6. 2003
    ..We reviewed retrospectively the cases of inhalant misuse reported to the Spanish Poison Control Center...
  65. ncbi Comparative oxidation and net emissions of methane and selected non-methane organic compounds in landfill cover soils
    Charlotte Schuetz
    Environment and Resources, Technical University of Denmark, DK 2800 Lyngby, Denmark
    Environ Sci Technol 37:5150-8. 2003
    ..The 37 NMOCs quantified in the landfill gas samples included alkanes (C1-C10), alkenes (C1-C4), halogenated hydrocarbons (including (H)CFCs), and aromatic hydrocarbons. Both positive and negative CH4 fluxes ranging from -0...
  66. ncbi Attenuation of methane and volatile organic compounds in landfill soil covers
    Charlotte Scheutz
    Environment and Resources, Bygningstorvet Building 115, Technical University of Denmark, DK 2800 Lyngby, Denmark
    J Environ Qual 33:61-71. 2004
    ..03 and 1.7 microg g(-1) h(-1). Fully halogenated hydrocarbons (PCE, tetrachloromethane [TeCM], chlorofluorocarbon [CFC]-11, CFC-12, and CFC-113) were not degraded in ..
  67. ncbi Polybrominated diphenyl ethers, polychlorinated dibenzo-dioxins, -furans, and -biphenyls in three species of Antarctic penguins
    Simonetta Corsolini
    Dipartimento di Scienze Ambientali G Sarfatti, University of Siena, 53100 Siena, Italy
    Environ Sci Pollut Res Int 14:421-9. 2007
    ..The potential toxicity of twenty-two dioxin-like congeners was assessed and expressed as 2,3,7,8-tetraCDD equivalents (TEQs). Differences between males and females were investigated...
  68. ncbi Chemical contamination of potable water in ship tanks
    Marcus Oldenburg
    Hamburg Port Health Center, Institute of Occupational and Maritime Medicine ZfAM, University of Hamburg, Germany
    Int Marit Health 58:79-91. 2007
    ..The aim of this study was to explore the frequency of drinking water contamination by chemicals in a selected sample of vessels and to assess the usefulness of recommended control measures...
  69. ncbi The cytochrome P-450 isoenzyme CYP2E1 in the biological processing of industrial chemicals: consequences for occupational and environmental medicine
    Hermann M Bolt
    Institut fur Arbeitsphysiologie, University of Dortmund, Ardeystrasse 67, 44139 Dortmund, Germany
    Int Arch Occup Environ Health 76:174-85. 2003
    ..a. alkanes, alkenes, aromatic and halogenated hydrocarbons)...
  70. ncbi Determination of volatile organic hydrocarbons in water samples by solid-phase dynamic extraction
    Maik A Jochmann
    Center for Applied Geoscience ZAG, Eberhard Karls Universitat Tubingen, Sigwartstr 10, 72076, Tubingen, Germany
    Anal Bioanal Chem 387:2163-74. 2007
    ..coupled to gas chromatography-mass spectrometry (HS-SPDE-GC/MS) for the trace determination of volatile halogenated hydrocarbons and benzene from groundwater samples was developed and evaluated...
  71. ncbi Characterization of two distinct aryl hydrocarbon receptor (AhR2) genes in Atlantic salmon (Salmo salar) and evidence for multiple AhR2 gene lineages in salmonid fish
    Maria C Hansson
    Department of Animal Ecology, Lund University, Ecology Building, Solvegatan 37, Sweden
    Gene 303:197-206. 2003
    ..g. 2,3,7,8-tetrachlorodibenzo-p-dioxin, and other halogenated hydrocarbons in vertebrates...
  72. ncbi Neuroembryopathic effect of trichloroacetic acid in rats exposed during organogenesis
    Royana Singh
    Department of Anatomy, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
    Birth Defects Res B Dev Reprod Toxicol 77:47-52. 2006
    b>Halogenated hydrocarbons such as trichloroacetic acid (TCA) are among the most common water supply contaminants in the world. This study examines the effect of TCA on the developing brain of the Charles Foster rat.
  73. doi DNA damage induced by nitrous oxide: study in medical personnel of operating rooms
    Teresa Wronska-Nofer
    Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, 8 Teresy St, 91 348 Lodz, Poland
    Mutat Res 666:39-43. 2009
    Occupational exposure to anaesthetics such as nitrous oxide (N(2)O) and halogenated hydrocarbons has been suggested to increase risk of genetic damage...
  74. pmc Environmental chemical exposures and disturbances of heme synthesis
    W E Daniell
    Department of Environmental Health, University of Washington, Seattle 98195 7234, USA
    Environ Health Perspect 105:37-53. 1997
    ..A number of chemicals, particularly metals and halogenated hydrocarbons, induce disturbances of heme synthesis in experimental animals...
  75. ncbi A validated method for the quantitation of 1,1-difluoroethane using a gas in equilibrium method of calibration
    Joseph Avella
    Department of Pharmaceutical Sciences, St John s University, Jamaica, New York, USA
    J Anal Toxicol 32:680-7. 2008
    1,1-Difluoroethane (DFE), also known as Freon 152A, is a member of a class of compounds known as halogenated hydrocarbons. A number of these compounds have gained notoriety because of their ability to induce rapid onset of intoxication ..
  76. ncbi Binding of thiopental to human serum albumin in the presence of halogenated hydrocarbons and ethers
    U Buch
    Institut für Anästhesie, Universitat des Saarlandes, Homburg Saar, FRG
    Methods Find Exp Clin Pharmacol 12:53-60. 1990
    ..Other halogenated hydrocarbons such as chloroform (6.2.10(-3) M) and carbon tetrachloride (5.2...
  77. ncbi Purification and characterization of human kidney cytosolic cysteine conjugate beta-lyase activity
    L H Lash
    Department of Pharmacology, University of Rochester School of Medicine and Dentistry, NY
    Drug Metab Dispos 18:50-4. 1990
    The central role of cysteine conjugate beta-lyase (beta-lyase) in the bioactivation of nephrotoxic halogenated hydrocarbons and the possibility of human exposure to these chemicals has focused interest on the beta-lyase from human kidney...
  78. ncbi Atmospheric emissions and attenuation of non-methane organic compounds in cover soils at a French landfill
    C Scheutz
    Institute of Environment and Resources, Technical University of Denmark, Bygningstorvet Building 115, DK 2800 Lyngby, Denmark
    Waste Manag 28:1892-908. 2008
    ..may contain more than 200 non-methane organic compounds (NMOCs) including C(2+)-alkanes, aromatics, and halogenated hydrocarbons. Although the trace components make up less than 1% v/v of typical landfill gas, they may exert a ..
  79. ncbi Binding of polycyclic aromatic hydrocarbons (PAHs) to teleost aryl hydrocarbon receptors (AHRs)
    Sonya M Billiard
    Department of Biology, Queen s University, ON, Kingston, Canada
    Comp Biochem Physiol B Biochem Mol Biol 133:55-68. 2002
    ..that exposure of the early life stages of fish to PAH can mimic the embryotoxic effects of the planar halogenated hydrocarbons (PHHs), the most potent of which is 2,3,7,8-tetrachlorodibenzo-p-dioxin...
  80. ncbi The importance of hydrophobicity and electrophilicity descriptors in mechanistically-based QSARs for toxicological endpoints
    M T D Cronin
    School of Pharmacy and Chemistry, Liverpool John Moores University, UK
    SAR QSAR Environ Res 13:167-76. 2002
    ..aliphatic alcohols on the perfused rat liver; the toxicity of 21 pyridines to mice; the lethality of 55 halogenated hydrocarbons to the mould Aspergillus nidulans)...
  81. ncbi Disposition of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) in two Norwegian epibenthic marine food webs
    Anders Ruus
    Norwegian Institute for Water Research NIVA, P O Box 173, Kjelsas, N 0411 Oslo, Norway
    Chemosphere 62:1856-68. 2006
    Polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) are a group of halogenated hydrocarbons, comprising 210 different, theoretically possible congeners...
  82. ncbi Hydrocarbon toxicity: an analysis of AAPCC TESS data
    Daniel J Cobaugh
    American Society of Health System, Pharmacists Research and Education Foundation, Bethesda, MD, USA
    Przegl Lek 64:194-6. 2007
    ..To determine which hydrocarbons were associated with the most severe adverse outcomes, human exposure data reported to American poison information centers were analyzed...
  83. ncbi A case of acute toxic hepatitis after suicidal chloroform and dichloromethane ingestion
    Hoon Kim
    Department of Emergency Medicine, College of Medicine, Chungbuk National University, Chungbuk 361 763, South Korea
    Am J Emerg Med 26:1073.e3-6. 2008
    Chloroform and dichloromethane are halogenated hydrocarbons that have been used as a potent anesthetic agent or a general industrial solvent...
  84. ncbi Bioactivation of halogenated hydrocarbons by rabbit pulmonary cells
    W K Nichols
    Department of Pharmacology and Toxicology, University of Utah, Salt Lake City 84112
    Pharmacol Toxicol 71:335-9. 1992
    ..1,1-Dichloro-2,2-bis (4'-chlorophenyl)ethane (DDD), 1,2-dibromoethane (DBE) and trichloroethylene are three halogenated hydrocarbons that selectively bind to pulmonary epithelial cells and that may be pneumotoxic...
  85. ncbi Microbial signature lipid profiling and exopolysaccharides: experiences initiated with Professor David C White and transported to Tasmania, Australia
    Peter D Nichols
    CSIRO Marine and Atmospheric Research, CSIRO Food Futures Flagship, GPO Box 1538, Hobart, Tasmania 7000, Australia
    J Microbiol Methods 74:33-46. 2008
    ..of the DMDS procedure in taxonomic and environmental studies including the degradation of pollutant halogenated hydrocarbons in groundwater and subsurface aquifers; exploiting the ubiquitous nature of uronic acids in microbial EPS ..
  86. ncbi Factors affecting the storage and excretion of toxic lipophilic xenobiotics
    R J Jandacek
    The University of Cincinnati, Department of Pathology, Ohio 45267, USA
    Lipids 36:1289-305. 2001
    ..toxic materials have been the recent focus of international effort to reduce or eliminate classes of halogenated hydrocarbons from the environment...
  87. ncbi Is the white-ivory assay of Drosophila melanogaster a useful tool in genetic toxicology?
    J A Ferreiro
    Departamento de Biologia Funcional, Universidad de Oviedo, Spain
    Environ Mol Mutagen 29:406-17. 1997
    ..agents, DNA-topoisomerase inhibitors, antimetabolites/nucleotide pool inhibitors, cyclic-adduct inducers, halogenated hydrocarbons, bulky-adduct inducers, intercalating agents, oxidative damage inducers, and a multiple damage inducer, ..
  88. ncbi Landfill modelling in LCA - a contribution based on empirical data
    Gudrun Obersteiner
    Institute of Waste Management, Department Water Atmosphere Environment, BOKU University of Natural Resources and Applied Life Science, Muthgasse 107, 1190 Vienna, Austria
    Waste Manag 27:S58-74. 2007
    ..produced by the leachate (heavy metals, organic loading), emissions into the air (CH(4), hydrocarbons, halogenated hydrocarbons) and from the energy or fuel requirements for the operation of the landfill (SO(2) and NO(x) from the ..
  89. pmc Enhanced metabolism of halogenated hydrocarbons in transgenic plants containing mammalian cytochrome P450 2E1
    S L Doty
    Department of Biochemistry, Box 357350, and College of Forest Resources, Box 352100, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 97:6287-91. 2000
    ..Therefore, transgenic plants with this enzyme could be used for more efficient remediation of many sites contaminated with halogenated hydrocarbons.
  90. ncbi Occurrence of organic contaminants in sewage sludges from eleven wastewater treatment plants, China
    Quan Ying Cai
    College of Resources and Environment, South China Agricultural University, Guangzhou, China
    Chemosphere 68:1751-62. 2007
    ..w.), respectively, followed by chlorobenzenes, nitroaromatics, haloethers and halogenated hydrocarbons which occurred generally at concentrations lower than 10mgkg(-1) d.w...
  91. ncbi Improved analysis of volatile halogenated hydrocarbons in water by purge-and-trap with gas chromatography and mass spectrometric detection
    Lelio Zoccolillo
    Dipartimento di Chimica, Universita degli Studi di Roma La Sapienza, Ple Aldo Moro 5, 00185 Rome, Italy
    J Chromatogr A 1077:181-7. 2005
    ..Our method has been successfully used on real samples: tap water, mineral water and Antarctic snow...
  92. ncbi Occurrence of priority organic pollutants in the fertilizers, China
    Ce Hui Mo
    Department of Environmental Engineering, Jinan University, Guangzhou 510632, China
    J Hazard Mater 152:1208-13. 2008
    ..w.), followed by polycyclic aromatic hydrocarbons (PAHs; <140 microg kg(-1) d.w.) and halogenated hydrocarbons (<900 microg kg(-1) d.w.). Chlorobenzenes and haloethers occurred generally at low concentrations...
  93. ncbi [SIN survey on quality control of dialysis water in Italy]
    G Bonfant
    U O di Nefrologia e Dialisi, Ospedale di Aosta, Aosta, Italy
    G Ital Nefrol 22:241-5. 2005
    ..The importance of high quality water for dialysis is well established. This study aimed to obtain a picture of the Italian situation to develop national guidelines...
  94. doi Differential sensitivity of CYP1A to 3,3',4',4-tetrachlorobiphenyl and benzo(a)pyrene in two Lepomis species
    Ben F Brammell
    Department of Biology, University of Kentucky, Lexington, KY 40506, USA
    Comp Biochem Physiol C Toxicol Pharmacol 152:42-50. 2010
    ..be an excellent biomarker for PAH pollution, but may not be a reliable indicator of site contamination by halogenated hydrocarbons. We conclude that Lepomis species provide a useful model for examining the regulation and potential ..
  95. doi Thinner intoxication manifesting as methemoglobinemia
    Sanjay Verma
    Department of Pediatrics UCMS and GTB Hospital, Delhi, India
    Indian J Pediatr 76:315-6. 2009
    ..commonly used for removing household paints is known to contain mixture of various arometic hydrocarbons; halogenated hydrocarbons and naptha, if ingested may rarely cause methemoglobinemia...
  96. ncbi [The mutagenicity of organic microcontamination in the environment. II. The mutagenicity of volatile organic halogens in the Salmonella microsome test (Ames Test) with regard to the contamination of groundwater and drinking water]
    V Mersch Sundermann
    ,
    Zentralbl Bakteriol Mikrobiol Hyg B 187:230-43. 1989
    ..sensitivity and specificity of microbial shortterm-tests for the registration of the mutagenic potency of halogenated hydrocarbons (OHV) 18 pure substances out of the groups of halomethanes, -ethanes and -ethylenes were examined with ..
  97. doi Immunohistochemical studies on early stage of hepatic damage induced by subacute inhalation of toluene vapor in rats
    Takako Gotohda
    Department of Forensic Medicine, Tokushima University School of Medicine, Kuramoto, Tokushima 770 8503, Japan
    J Appl Toxicol 29:505-9. 2009
    ..to be vulnerable and susceptible to various organic solvents, particularly chloroform and other halogenated hydrocarbons, the hepatotoxic effects of aromatic hydrocarbons including toluene have not yet been sufficiently ..
  98. doi Analysis of persistent halogenated hydrocarbons in fish feeds containing fish oil and other alternative lipid sources
    Jing You
    State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, China
    Talanta 85:1291-7. 2011
    A trade-off exists between beneficial n-3 long-chain polyunsaturated acids and toxic persistent halogenated hydrocarbons (PHHs), both of which primarily originate from fish oil commonly used in fish feeds...
  99. ncbi The aryl hydrocarbon receptor, a basic helix-loop-helix transcription factor of the PAS gene family, is required for normal ovarian germ cell dynamics in the mouse
    R Robles
    Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston 02114, USA
    Endocrinology 141:450-3. 2000
    ..of the protein to bind with and be activated by polycyclic aromatic hydrocarbons (PAH) and related halogenated hydrocarbons, is part of an emerging family of ligand-activated transcriptional regulators that are distinct from the ..
  100. pmc Threshold of trichloroethylene contamination in maternal drinking waters affecting fetal heart development in the rat
    Paula D Johnson
    University Animal Care, University of Arizona, Tucson, Arizona, USA
    Environ Health Perspect 111:289-92. 2003
    b>Halogenated hydrocarbons such as trichloroethylene (TCE) are among the most common water supply contaminants in the United States and abroad...
  101. ncbi Environmental risk factors for mycosis fungoides
    Yonit Wohl
    Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Curr Probl Dermatol 35:52-64. 2007
    ..recent epidemiological data indicate that occupational exposure to chemicals, primarily to aromatic halogenated hydrocarbons, is a major risk factor to develop MF in men (odds ratio 4...

Research Grants72

  1. BIOACTIVATION OF HALOGENATED HYDROCARBONS
    F Guengerich; Fiscal Year: 2005
    DESCRIPTION: Many halogenated hydrocarbons are of interest because of their high production volume and demonstrated ability to cause cancers in experimental animals...
  2. Antibacterial, antifungal, antiviral, and antispore paints
    YUYU contact SUN; Fiscal Year: 2010
    ..none corrosive, with no reported cases of microbial resistance, and have a much less tendency to generate halogenated hydrocarbons. In our technology, a new N-halamine monomer developed in our lab, N-chloro-2,2,6,6- tetramethyl-4-..
  3. Antibacterial, antifungal, antiviral, and antispore paints
    YUYU contact SUN; Fiscal Year: 2011
    ..none corrosive, with no reported cases of microbial resistance, and have a much less tendency to generate halogenated hydrocarbons. In our technology, a new N-halamine monomer developed in our lab, N-chloro-2,2,6,6- tetramethyl-4-..
  4. FREE RADICAL LIPID PEROXIDATION DAMAGE
    ALOYS TAPPEL; Fiscal Year: 1990
    ..For screening initiators (halogenated hydrocarbons and peroxides) and antioxidants, thiobarbituric acid-reactive substances; release of ethane and pentane; ..
  5. MOLECULAR MECHANISMS OF DIOXIN ACTION
    Alvaro Puga; Fiscal Year: 1993
    ..TCDD is the prototype congener of the halogenated hydrocarbons, a group of toxic environmental pollutants known to be potent immunosuppresssors, teratogens, and tumor ..
  6. Antibiofilm tubing to reduce occupational exposure to biohazards in dentistry
    Yuyu Sun; Fiscal Year: 2009
    ..settings, but N-halamines are more stable, less corrosive, and have much less tendency to generate halogenated hydrocarbons. It is anticipated that after covalently binding N-halamines onto plastic tubes, the new tubes will be ..
  7. Halogenated Alkenes and Microsomal GSH-transferases
    Michael Kelner; Fiscal Year: 2009
    ..Unlike other halogenated hydrocarbons, vicinal haloalkenes uniquely damage the kidney by destroying proximal tubule cells and induce renal ..
  8. Halogenated Alkenes and Microsomal GSH-transferases
    Michael Kelner; Fiscal Year: 2007
    ..Unlike other halogenated hydrocarbons, vicinal haloalkenes uniquely damage the kidney by destroying proximal tubule cells and induce renal ..
  9. Halogenated Alkenes and Microsomal GSH-transferases
    Michael Kelner; Fiscal Year: 2007
    ..Unlike other halogenated hydrocarbons, vicinal haloalkenes uniquely damage the kidney by destroying proximal tubule cells and induce renal ..
  10. Halogenated Alkenes and Microsomal GSH-transferases
    Michael J Kelner; Fiscal Year: 2010
    ..Unlike other halogenated hydrocarbons, vicinal haloalkenes uniquely damage the kidney by destroying proximal tubule cells and induce renal ..
  11. Halogenated Alkenes and Microsomal GSH-transferases
    Michael Kelner; Fiscal Year: 2006
    ..Unlike other halogenated hydrocarbons, vicinal haloalkenes uniquely damage the kidney by destroying proximal tubule cells and induce renal ..
  12. REGULATION OF C-1 METABOLISM IN METHYLOTROPHS
    Mary Lidstrom; Fiscal Year: 1990
    ..of cooxidizing a variety of other compounds including straight-chain and cyclic hydrocarbons, as well as halogenated hydrocarbons. Since many of these compounds are toxic, methylotrophs appear to play an important role in ..
  13. FLAVOPROTEINS IN FATTY ACID METABOLISM
    Colin Thorpe; Fiscal Year: 1999
    ..A fourth aim addresses the mode of action of cytotoxic 4-thia-fatty acid derivatives of halogenated hydrocarbons such as trichloroethylene...
  14. BIOACTIVATION OF HALOGENATED HYDROCARBONS
    F Guengerich; Fiscal Year: 2002
    DESCRIPTION: Many halogenated hydrocarbons are of interest because of their high production volume and demonstrated ability to cause cancers in experimental animals...
  15. BIOACTIVATION OF HALOGENATED HYDROCARBONS
    F Guengerich; Fiscal Year: 2001
    DESCRIPTION: Many halogenated hydrocarbons are of interest because of their high production volume and demonstrated ability to cause cancers in experimental animals...
  16. BIOACTIVATION OF HALOGENATED HYDROCARBONS
    F Guengerich; Fiscal Year: 2003
    DESCRIPTION: Many halogenated hydrocarbons are of interest because of their high production volume and demonstrated ability to cause cancers in experimental animals...
  17. BIOACTIVATION OF HALOGENATED HYDROCARBONS
    F Guengerich; Fiscal Year: 2004
    DESCRIPTION: Many halogenated hydrocarbons are of interest because of their high production volume and demonstrated ability to cause cancers in experimental animals...
  18. METABOLISM AND TOXICITY OF HALOGENATED HYDROCARBONS
    MARION ANDERS; Fiscal Year: 2000
    ....
  19. METABOLISM AND TOXICITY OF HALOGENATED HYDROCARBONS
    MARION ANDERS; Fiscal Year: 1999
    ....
  20. HUMAN METABOLISM OF HALOTHANE--MARKERS OF TOXIC EXPOSURE
    James Trudell; Fiscal Year: 1992
    ..The following experiments with halothane will also contribute to the understanding of how other halogenated hydrocarbons cause liver disease and cancer...
  21. Toxicological Control Mechanisms of Human CYP1A2
    LINDA QUATTROCHI; Fiscal Year: 2002
    ..g. polycyclic aromatic hydrocarbons and halogenated hydrocarbons), dietary constituents (e.g. heterocyclic amines, flavones, indoles) and genetic factors...
  22. Toxicological Control Mechanisms of Human CYP1A2
    LINDA QUATTROCHI; Fiscal Year: 2003
    ..g. polycyclic aromatic hydrocarbons and halogenated hydrocarbons), dietary constituents (e.g. heterocyclic amines, flavones, indoles) and genetic factors...
  23. Toxicological Control Mechanisms of Human CYP1A2
    LINDA QUATTROCHI; Fiscal Year: 2002
    ..g. polycyclic aromatic hydrocarbons and halogenated hydrocarbons), dietary constituents (e.g. heterocyclic amines, flavones, indoles) and genetic factors...
  24. Toxicological Control Mechanisms of Human CYP1A2
    LINDA QUATTROCHI; Fiscal Year: 2004
    ..g. polycyclic aromatic hydrocarbons and halogenated hydrocarbons), dietary constituents (e.g. heterocyclic amines, flavones, indoles) and genetic factors...
  25. Toxicological Control Mechanisms of Human CYP1A2
    LINDA QUATTROCHI; Fiscal Year: 2001
    ..g. polycyclic aromatic hydrocarbons and halogenated hydrocarbons), dietary constituents (e.g. heterocyclic amines, flavones, indoles) and genetic factors...
  26. METABOLISM AND TOXICITY OF HALOGENATED HYDROCARBONS
    MARION ANDERS; Fiscal Year: 2003
    ..Abstract): The broad objective of the proposed research is to investigate the metabolism and toxicity of halogenated hydrocarbons. This competitive renewal application will be focused on the glutathione transferase zeta (GSTZ 1-1)-..
  27. METABOLISM AND TOXICITY OF HALOGENATED HYDROCARBONS
    MARION ANDERS; Fiscal Year: 2002
    ..Abstract): The broad objective of the proposed research is to investigate the metabolism and toxicity of halogenated hydrocarbons. This competitive renewal application will be focused on the glutathione transferase zeta (GSTZ 1-1)-..
  28. METABOLISM AND TOXICITY OF HALOGENATED HYDROCARBONS
    MARION ANDERS; Fiscal Year: 2004
    ..Abstract): The broad objective of the proposed research is to investigate the metabolism and toxicity of halogenated hydrocarbons. This competitive renewal application will be focused on the glutathione transferase zeta (GSTZ 1-1)-..
  29. METABOLISM AND TOXICITY OF HALOGENATED HYDROCARBONS
    MARION ANDERS; Fiscal Year: 2001
    ..Abstract): The broad objective of the proposed research is to investigate the metabolism and toxicity of halogenated hydrocarbons. This competitive renewal application will be focused on the glutathione transferase zeta (GSTZ 1-1)-..
  30. Susceptibility to Trichloroetylene
    Ornella Selmin; Fiscal Year: 2005
    ..In particular, we will explore the possibility that these halogenated hydrocarbons may disrupt specific biochemical processes that are essential for the normal embryonic differentiation ..
  31. AH RECEPTOR/TRANSCRIPTION FACTOR AS A REGULATOR OF HYDROCARBON BIOACTIVITY
    David Sherr; Fiscal Year: 2002
    Polycyclic aromatic hydrocarbons (PAH) and related halogenated hydrocarbons are environmental chemicals present at high concentrations in Superfund hazardous waste sites...
  32. AH RECEPTOR/TRANSCRIPTION FACTOR AS A REGULATOR OF HYDROCARBON BIOACTIVITY
    David Sherr; Fiscal Year: 2002
    Polycyclic aromatic hydrocarbons (PAH) and related halogenated hydrocarbons are environmental chemicals present at high concentrations in Superfund hazardous waste sites...
  33. AH RECEPTOR/TRANSCRIPTION FACTOR AS A REGULATOR OF HYDROCARBON BIOACTIVITY
    David Sherr; Fiscal Year: 2000
    Polycyclic aromatic hydrocarbons (PAH) and related halogenated hydrocarbons are environmental chemicals present at high concentrations in Superfund hazardous waste sites...
  34. AH RECEPTOR/TRANSCRIPTION FACTOR AS A REGULATOR OF HYDROCARBON BIOACTIVITY
    David Sherr; Fiscal Year: 2001
    Polycyclic aromatic hydrocarbons (PAH) and related halogenated hydrocarbons are environmental chemicals present at high concentrations in Superfund hazardous waste sites...
  35. METHANE OXIDATION BY METHANOTROPHS
    Mary Lidstrom; Fiscal Year: 1990
    ..a variety of non-growth substrates including straight-chain and cyclic hydrocarbons, as well as halogenated hydrocarbons. Since many of these compounds are toxic, it is of considerable interest to study this cooxidation ..
  36. INTERACTIVE TOXICITY--SUPERFUND HAZARDOUS SUBSTANCES
    DEAN CARTER; Fiscal Year: 1990
    ..The degredation of halogenated hydrocarbons and the bacteria which can accomplish these reactions are to be examined...
  37. EPIDEMIOLOGY OF PRIMARY BILIARY CIRRHOSIS
    MERRILL GERSHWIN; Fiscal Year: 2004
    ..e. human) analogs. Alternatively, the liver-based metabolism of halogenated hydrocarbons as xenobiotics generates activated halogen containing intermediates that react to form halogen modified ..
  38. EPIDEMIOLOGY OF PRIMARY BILIARY CIRRHOSIS
    MERRILL GERSHWIN; Fiscal Year: 2001
    ..e. human) analogs. Alternatively, the liver-based metabolism of halogenated hydrocarbons as xenobiotics generates activated halogen containing intermediates that react to form halogen modified ..
  39. EPIDEMIOLOGY OF PRIMARY BILIARY CIRRHOSIS
    MERRILL GERSHWIN; Fiscal Year: 2003
    ..e. human) analogs. Alternatively, the liver-based metabolism of halogenated hydrocarbons as xenobiotics generates activated halogen containing intermediates that react to form halogen modified ..
  40. EPIDEMIOLOGY OF PRIMARY BILIARY CIRRHOSIS
    MERRILL GERSHWIN; Fiscal Year: 2000
    ..e. human) analogs. Alternatively, the liver-based metabolism of halogenated hydrocarbons as xenobiotics generates activated halogen containing intermediates that react to form halogen modified ..
  41. EPIDEMIOLOGY OF PRIMARY BILIARY CIRRHOSIS
    MERRILL GERSHWIN; Fiscal Year: 2002
    ..e. human) analogs. Alternatively, the liver-based metabolism of halogenated hydrocarbons as xenobiotics generates activated halogen containing intermediates that react to form halogen modified ..
  42. BIOACTIVATION OF HALOGENATED HYDROCARBONS
    F Guengerich; Fiscal Year: 2009
    b>Halogenated hydrocarbons are major industrial chemicals and are of environmental and lexicological concern because of potential hazards to human health...
  43. BIOACTIVATION OF HALOGENATED HYDROCARBONS
    F Peter Guengerich; Fiscal Year: 2010
    b>Halogenated hydrocarbons are major industrial chemicals and are of environmental and lexicological concern because of potential hazards to human health...
  44. BIOACTIVATION OF HALOGENATED HYDROCARBONS
    F Guengerich; Fiscal Year: 2007
    b>Halogenated hydrocarbons are major industrial chemicals and are of environmental and lexicological concern because of potential hazards to human health...
  45. ANALYSIS OF FAT-SOLUBLE HYDROCARBONS IN SEBUM
    Mary Wolff; Fiscal Year: 1980
    ..clinical studies and individual patient requests performed over 3000 analyses to assess exposure to halogenated hydrocarbons of environmental origin...
  46. HAIR AS A MONITOR OF TOXIC CHEMICALS EXPOSURE
    MARTIN MACH; Fiscal Year: 1980
    ..The latter include selected halogenated hydrocarbons, including polychlorinated biphenyls, and hydrazines, which were chosen for study on the basis of their ..
  47. ROLE OF CYTOCHROME P-450 IN DRUG REDUCTION
    Garth Powis; Fiscal Year: 1980
    ..is an important site for the reduction of at least two classes of compounds, tertiary amine N-oxides and halogenated hydrocarbons, and that different forms of cytochrome P-450 catalyze oxidative and reductive reactions...
  48. Role of CYP2E1 and ADH in Human TRI Teratogenicity
    D McCarver; Fiscal Year: 2003
    Congenital heart disease is a major cause of mortality and morbidity. Exposure to halogenated hydrocarbons, specifically trichloroethylene (TRI), during pregnancy has been associated with congenital heart disease in animal models and ..
  49. MECHANISMS OF HALOCARBON-INDUCED PNEUMOTOXICITES
    GAROLD YOST; Fiscal Year: 1992
    ..the basic biochemical, chemical, and molecular biological mechanisms for the pneumotoxicity of three halogenated hydrocarbons: trichloroethylene (TRI); 2-(4-chlorophenyl)-2- (4-chlorophenyl)-1,1-dichloroethane (DDD); and 1,2-..
  50. Role of CYP2E1 and ADH in Human TRI Teratogenicity
    D McCarver; Fiscal Year: 2001
    Congenital heart disease is a major cause of mortality and morbidity. Exposure to halogenated hydrocarbons, specifically trichloroethylene (TRI), during pregnancy has been associated with congenital heart disease in animal models and ..
  51. Role of CYP2E1 and ADH in Human TRI Teratogenicity
    D McCarver; Fiscal Year: 2002
    Congenital heart disease is a major cause of mortality and morbidity. Exposure to halogenated hydrocarbons, specifically trichloroethylene (TRI), during pregnancy has been associated with congenital heart disease in animal models and ..
  52. Role of CYP2E1 and ADH in Human TRI Teratogenicity
    D McCarver; Fiscal Year: 2005
    Congenital heart disease is a major cause of mortality and morbidity. Exposure to halogenated hydrocarbons, specifically trichloroethylene (TRI), during pregnancy has been associated with congenital heart disease in animal models and ..
  53. INCREASE OF TOXICITY OF TRACE ANESTHETICS BY UV LIGHT
    JOANNES KARIS; Fiscal Year: 1980
    Ultraviolet irradiation is used in some operating rooms to decrease intraoperative wound infection. Halogenated hydrocarbons are commonly used as anesthetic agents and are known to undergo photodecomposition...
  54. Role of CYP2E1 and ADH in Human TRI Teratogenicity
    D McCarver; Fiscal Year: 2004
    Congenital heart disease is a major cause of mortality and morbidity. Exposure to halogenated hydrocarbons, specifically trichloroethylene (TRI), during pregnancy has been associated with congenital heart disease in animal models and ..
  55. PET STUDY OF BIOCHEMISTRY AND METABOLISM OF THE CNS
    WILLIAM BEIERWALTES; Fiscal Year: 1980
    ..Inert halogenated hydrocarbons will be employed to visualize brain white matter in associated feasibility studies from multiple ..
  56. DEVELOPMENT OF MITOTANE ANALOGS FOR ADRENAL CANCER
    David Schteingart; Fiscal Year: 1990
    ..studies with Mitotane and Mitometh and reports on the activation metabolism of p,p'-DDD and other halogenated hydrocarbons, we postulate that the adrenalytic action of Mitotane is linked to the ability of the dichloromethyl ..
  57. SUPERFUND CHEMICALS: TRANSPORT, METABOLISM & TOXICITY
    Larry Robertson; Fiscal Year: 2002
    ..submitted to support our focused research include health-related projects that investigate mechanisms of halogenated hydrocarbons has initiating, promoting, and metastasis-enhancing agents in carcinogenesis (Projects #1, #3, and #7) ..
  58. SUPERFUND CHEMICALS: TRANSPORT, METABOLISM & TOXICITY
    Larry Robertson; Fiscal Year: 2000
    ..submitted to support our focused research include health-related projects that investigate mechanisms of halogenated hydrocarbons has initiating, promoting, and metastasis-enhancing agents in carcinogenesis (Projects #1, #3, and #7) ..
  59. HUMAN METABOLISM OF HALOTHANE-MECHANISMS OF TOXICITY
    James Trudell; Fiscal Year: 1990
    ..The following experiments with halothane will also contribute to the understanding of how other halogenated hydrocarbons cause liver disease and cancer...
  60. SUPERFUND CHEMICALS: TRANSPORT, METABOLISM & TOXICITY
    Bernhard Hennig; Fiscal Year: 2003
    ..submitted to support our focused research include health-related projects that investigate mechanisms of halogenated hydrocarbons has initiating, promoting, and metastasis-enhancing agents in carcinogenesis (Projects #1, #3, and #7) ..
  61. SUPERFUND CHEMICALS: TRANSPORT, METABOLISM & TOXICITY
    Larry Robertson; Fiscal Year: 2001
    ..submitted to support our focused research include health-related projects that investigate mechanisms of halogenated hydrocarbons has initiating, promoting, and metastasis-enhancing agents in carcinogenesis (Projects #1, #3, and #7) ..
  62. SUPERFUND CHEMICALS: TRANSPORT, METABOLISM & TOXICITY
    Bernhard Hennig; Fiscal Year: 2003
    ..submitted to support our focused research include health-related projects that investigate mechanisms of halogenated hydrocarbons has initiating, promoting, and metastasis-enhancing agents in carcinogenesis (Projects #1, #3, and #7) ..