halogenated hydrocarbons

Summary

Top Publications

  1. ncbi Plasma levels of persistent organohalogens and hormone levels in adult male humans
    L Hagmar
    Department of Occupational and Environmental Medicine, University Hospital, Lund, Sweden
    Arch Environ Health 56:138-43. 2001
  2. ncbi Fast-track DRESSA: a bioassay for fast, sensitive, and selective detection of halogenated and polycyclic aromatic hydrocarbons
    Ayumi Kasai
    Department of Biochemistry, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Tamaho, Yamanashi 409 3898, Japan
    Anal Biochem 337:84-8. 2005
  3. ncbi Persistent halogenated hydrocarbons in consumer fish of China: regional and global implications for human exposure
    Xiang Zhou Meng
    State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China
    Environ Sci Technol 41:1821-7. 2007
  4. ncbi In vitro assessment of the effect of halogenated hydrocarbons: chloroform, dichloromethane, and dibromoethane on embryonic development of the rat
    P D Brown-Woodman
    Department of Biochemical Sciences, Faculty of Health Sciences, University of Sydney, Lidcombe, N S W, Australia
    Teratology 57:321-33. 1998
  5. ncbi Histology of selected immunological organs in polar bear (Ursus maritimus) from East Greenland in relation to concentrations of organohalogen contaminants
    M Kirkegaard
    Department of Arctic Environment, National Environmental Research Institute, Frederiksborgvej 399, 4000 Denmark
    Sci Total Environ 341:119-32. 2005
  6. ncbi Efficient synthesis of alpha-aryl esters by room-temperature palladium-catalyzed coupling of aryl halides with ester enolates
    Morten Jørgensen
    Department of Chemistry, Yale University, P O Box 208107, New Haven, Connecticut 06520 8107, USA
    J Am Chem Soc 124:12557-65. 2002
  7. ncbi A soluble base for the copper-catalyzed imidazole N-arylations with aryl halides
    Longbin Liu
    Chemical Research and Discovery, Amgen Inc, One Amgen Center Drive, Thousand Oaks, California 91320, USA
    J Org Chem 70:10135-8. 2005
  8. ncbi Multifunctional palladium catalysis. 2. Tandem haloallylation followed by Wacker-Tsuji oxidation or sonogashira cross-coupling
    Avinash N Thadani
    Department of Chemistry, The University of Chicago, 5735 South Ellis Avenue, Chicago, Illinois 60637, USA
    Org Lett 4:4321-3. 2002
  9. ncbi An annulative approach to highly substituted indoles: unusual effect of phenolic additives on the success of the arylation of ketone enolates
    Jennifer L Rutherford
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 124:15168-9. 2002
  10. ncbi Isolation, structure determination, and biological activity of a novel alkaloid, perophoramidine, from the Philippine ascidian Perophora namei
    Sheryl M Verbitski
    Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    J Org Chem 67:7124-6. 2002

Research Grants

  1. MOLECULAR MECHANISMS OF DIOXIN ACTION
    Alvaro Puga; Fiscal Year: 2013
  2. Transgenerational Inheritance of Epigenetic Effects of Polychlorinated Biphenyls
    Charles V Vorhees; Fiscal Year: 2013
  3. Antibacterial, antifungal, antiviral, and antispore paints
    YUYU contact SUN; Fiscal Year: 2011
  4. Halogenated Alkenes and Microsomal GSH-transferases
    Michael J Kelner; Fiscal Year: 2010
  5. BIOACTIVATION OF HALOGENATED HYDROCARBONS
    F Peter Guengerich; Fiscal Year: 2013
  6. Pesticide Exposures and Risk of Preterm Birth
    Gary M Shaw; Fiscal Year: 2013
  7. HAZARDOUS WASTE RISK AND REMEDIATION IN THE SOUTHWEST
    Raina M Maier; Fiscal Year: 2013
  8. FREE RADICAL LIPID PEROXIDATION DAMAGE
    ALOYS TAPPEL; Fiscal Year: 1991
  9. Elucidating Risks: From Exposure and Mechanism to Outcome
    James A Swenberg; Fiscal Year: 2013
  10. Particulate Methane Monooxygenase
    Amy C Rosenzweig; Fiscal Year: 2013

Detail Information

Publications236 found, 100 shown here

  1. ncbi Plasma levels of persistent organohalogens and hormone levels in adult male humans
    L Hagmar
    Department of Occupational and Environmental Medicine, University Hospital, Lund, Sweden
    Arch Environ Health 56:138-43. 2001
    ..High consumption of organohalogen-polluted fish did not appear to affect plasma concentrations of pituitary, thyroid, or testosterone hormone levels in male adults...
  2. ncbi Fast-track DRESSA: a bioassay for fast, sensitive, and selective detection of halogenated and polycyclic aromatic hydrocarbons
    Ayumi Kasai
    Department of Biochemistry, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Tamaho, Yamanashi 409 3898, Japan
    Anal Biochem 337:84-8. 2005
    ..Because of its time-saving property and easiness, sensitiveness, and specificity, the fast-track DRESSA would be advantageous for high-throughput screening of dioxin and dioxin-like compounds in environmental samples...
  3. ncbi Persistent halogenated hydrocarbons in consumer fish of China: regional and global implications for human exposure
    Xiang Zhou Meng
    State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China
    Environ Sci Technol 41:1821-7. 2007
    Concentrations of persistent halogenated hydrocarbons (PHHs) were determined in 13 consumer fish species (a total of 390 individuals) collected from a major fish-farming region of China...
  4. ncbi In vitro assessment of the effect of halogenated hydrocarbons: chloroform, dichloromethane, and dibromoethane on embryonic development of the rat
    P D Brown-Woodman
    Department of Biochemical Sciences, Faculty of Health Sciences, University of Sydney, Lidcombe, N S W, Australia
    Teratology 57:321-33. 1998
    b>Halogenated hydrocarbons are widely used in industry, the laboratory, and in the home...
  5. ncbi Histology of selected immunological organs in polar bear (Ursus maritimus) from East Greenland in relation to concentrations of organohalogen contaminants
    M Kirkegaard
    Department of Arctic Environment, National Environmental Research Institute, Frederiksborgvej 399, 4000 Denmark
    Sci Total Environ 341:119-32. 2005
    ....
  6. ncbi Efficient synthesis of alpha-aryl esters by room-temperature palladium-catalyzed coupling of aryl halides with ester enolates
    Morten Jørgensen
    Department of Chemistry, Yale University, P O Box 208107, New Haven, Connecticut 06520 8107, USA
    J Am Chem Soc 124:12557-65. 2002
    ....
  7. ncbi A soluble base for the copper-catalyzed imidazole N-arylations with aryl halides
    Longbin Liu
    Chemical Research and Discovery, Amgen Inc, One Amgen Center Drive, Thousand Oaks, California 91320, USA
    J Org Chem 70:10135-8. 2005
    ..Preliminary results with aryl chlorides are also reported...
  8. ncbi Multifunctional palladium catalysis. 2. Tandem haloallylation followed by Wacker-Tsuji oxidation or sonogashira cross-coupling
    Avinash N Thadani
    Department of Chemistry, The University of Chicago, 5735 South Ellis Avenue, Chicago, Illinois 60637, USA
    Org Lett 4:4321-3. 2002
    ..The homogeneous palladium dihalide catalyst utilized for the bromo-/chloroallylation of alkynes is reused in situ for subsequent Wacker-Tsuji oxidation or Sonogashira cross-coupling...
  9. ncbi An annulative approach to highly substituted indoles: unusual effect of phenolic additives on the success of the arylation of ketone enolates
    Jennifer L Rutherford
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 124:15168-9. 2002
    ..The products of this reaction were then readily reductively cyclized to give highly substituted indoles in moderate to excellent overall yields...
  10. ncbi Isolation, structure determination, and biological activity of a novel alkaloid, perophoramidine, from the Philippine ascidian Perophora namei
    Sheryl M Verbitski
    Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    J Org Chem 67:7124-6. 2002
    ..The structure of 1 was determined by the interpretation of 1D/2D NMR and MS data. Dehalogenation of perophoramidine (1) by ammonium formate catalyzed transfer hydrogenation confirmed the type and number of halogen atoms present in 1...
  11. ncbi Homogeneous catalysts supported on soluble polymers: biphasic Suzuki-Miyaura coupling of aryl chlorides using phase-tagged palladium-phosphine catalysts
    Markus an der Heiden
    Institut fur Anorganische Chemie, Petersenstrasse 18, TU Darmstadt, 64287 Darmstadt, Germany
    Chemistry 10:1789-97. 2004
    ..There is no apparent leaching of the catalyst into the heptane solution (<0.05 %), as evidenced by spectrophotometric measurements, and contamination of the product with Pd is avoided...
  12. ncbi Halo-enediynes: probing the electronic and stereoelectronic contributions to the Bergman cycloaromatization
    Gary W Plourde
    Department of Chemistry, Northeastern University, Boston, Massachusetts 02115, USA
    J Org Chem 67:5369-74. 2002
    ..In all cases studied the halogen atom had a strongly retardative effect on the thermal Bergman cycloaromatization reaction. The isolation of the first C-9 monochloroenediyne is noteworthy, and may find application in prodrug design...
  13. ncbi Reevaluation of the mechanism of the amination of aryl halides catalyzed by BINAP-ligated palladium complexes
    Shashank Shekhar
    Department of Chemistry, Yale University, P O Box 208107, New Haven, Connecticut 06520 8107, USA
    J Am Chem Soc 128:3584-91. 2006
    ..By this mechanism, the amine and base react with [Pd(BINAP)(Ar)(Br)] to form an arylpalladium amido complex, and reductive elimination from this amido complex forms the arylamine...
  14. ncbi Pd-catalyzed intermolecular amidation of aryl halides: the discovery that xantphos can be trans-chelating in a palladium complex
    Jingjun Yin
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 124:6043-8. 2002
    ..X-ray crystallographic analysis of II revealed a rare trans-chelating bisphosphine-Pd(II) structure with a large bite angle of 150.7 degrees...
  15. ncbi Diversity synthesis using the complimentary reactivity of rhodium(II)- and palladium(II)-catalyzed reactions
    Aiwu Ni
    Department of Chemistry, University at Buffalo, State University of New York, Buffalo, New York 14260, USA
    J Org Chem 71:5594-8. 2006
    ..The combination of the rhodium(II)-catalyzed reaction with a subsequent palladium(II)-catalyzed Suzuki coupling offers a novel strategy for diversity synthesis...
  16. ncbi Phosphine-free cross-coupling reaction of arylboronic acids with carboxylic anhydrides or acyl chlorides in aqueous media
    Bingwei Xin
    Department of Chemistry, Zhejiang University, Hangzhou 310027, P R China
    J Org Chem 71:5725-31. 2006
    ..The Pd(OAc)2-H2O-[bmim][PF6] catalytic system can be recovered and reused eight times with high efficiency for both carboxylic anhydride and acyl chloride...
  17. ncbi Palladium-catalyzed arylation of malonates and cyanoesters using sterically hindered trialkyl- and ferrocenyldialkylphosphine ligands
    Neil A Beare
    Department of Chemistry, Yale University, P O Box 208107, New Haven, Connecticut 06520 8107, USA
    J Org Chem 67:541-55. 2002
    ....
  18. ncbi Efficient pd-catalyzed amination of heteroaryl halides
    Mark D Charles
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Org Lett 7:3965-8. 2005
    ..In particular, we report the first couplings of amines with chloro- and bromoindoles bearing a free NH, as well as the first Pd-catalyzed aminations of a 5-halopyrimidine. [reaction: see text]..
  19. ncbi Preferential oxidative addition in palladium(0)-catalyzed suzuki cross-coupling reactions of dihaloarenes with arylboronic acids
    Cheng Guo Dong
    Department of Chemistry, College of Staten Island and the Graduate Center of the City University of New York, Staten Island, New York 10314, USA
    J Am Chem Soc 127:10006-7. 2005
    ..The results described here may lead to the development of new, efficient processes to conjugate polymers with controlled length which are potentially useful in molecular electronics...
  20. ncbi Palladium-catalyzed arylation of trimethylsilyl enolates of esters and imides. High functional group tolerance and stereoselective synthesis of alpha-aryl carboxylic acid derivatives
    Xiaoxiang Liu
    Department of Chemistry, Yale University, New Haven, Connecticut 06510 USA
    J Am Chem Soc 126:5182-91. 2004
    ..Mechanistic studies showed that the reaction conditions are neutral enough that the observed diastereomeric ratios reflect kinetic selectivities...
  21. ncbi Nickel-catalyzed cross-couplings of organosilicon reagents with unactivated secondary alkyl bromides
    David A Powell
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 126:7788-9. 2004
    ..Noteworthy attributes of the method are its scope (secondary electrophiles), its high functional-group compatibility, and the air stability of the catalyst components...
  22. ncbi The mechanisms of the Stille reaction
    Pablo Espinet
    Quimica Inorganica, Facultad de Ciencias, Universidad de Valladolid, 47005, Spain
    Angew Chem Int Ed Engl 43:4704-34. 2004
    ..The purpose of this Review is to give a critical account of this progress...
  23. ncbi Ring expansion-annulation strategy for the synthesis of substituted azulenes and oligoazulenes. 2. Synthesis of azulenyl halides, sulfonates, and azulenylmetal compounds and their application in transition-metal-mediated coupling reactions
    Aimee L Crombie
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Org Chem 69:8652-67. 2004
    ..The application of these coupling reactions to the synthesis of biazulenes, terazulene 101, and related oligoazulenes is described, as well as the preparation of the azulenyl amino acid derivative 110...
  24. ncbi Introduction of a third meso substituent into 5,10-diaryl chlorins and oxochlorins
    Masahiko Taniguchi
    Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695 8204, USA
    J Org Chem 70:275-85. 2005
    ..This study provides access to new chlorins/oxochlorins that can be utilized in diverse applications...
  25. ncbi Microwave-promoted Heck coupling using ultralow metal catalyst concentrations
    Riina K Arvela
    Department of Chemistry, University of Connecticut, Unit 3060, 55 North Eagleville Road, Storrs, Connecticut 06269 3060, USA
    J Org Chem 70:1786-90. 2005
    ..We show that Heck couplings can be performed in water using microwave heating and Pd catalyst concentrations as low as 500 ppb. The methodology is simple; all that is required as the catalyst is a stock solution of palladium...
  26. ncbi Isolation of halogenated monoterpenes from bioreactor-cultured microplantlets of the macrophytic red algae Ochtodes secundiramea and Portieria hornemannii
    Luis F Barahona
    CICY Biotecnologia, Apartado Postal 87, 97310 Cordemex, Merida, Mexico
    J Nat Prod 66:743-51. 2003
    ..This study demonstrated that bioreactor tissue culture is a new venue for bioprospecting and production of natural compounds from marine macroalgae under a controlled environment...
  27. ncbi Convergent synthesis of polyhalogenated quinoline C-nucleosides as potential antiviral agents
    Jiong J Chen
    Department of Chemistry, College of Literature, Sciences and Arts, University of Michigan, Ann Arbor 48109 1065, USA
    J Org Chem 68:4170-8. 2003
    ..The 2-aminophenone alpha-nucleoside (11) was successfully anomerized to the beta-anomer (19), which led to the synthesis of the targeted 2-chloro- and 2-bromo-6,7-dichloro-4-(beta-d-ribofuranosyl)quinolines (18and 21, respectively)...
  28. ncbi Omega-halonitriles: domino cyclizations to oxa- and carbocyclic nitriles
    Fraser F Fleming
    Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, Pennsylvania 15282 1530, USA
    J Org Chem 68:3943-6. 2003
    ..Collectively these cyclizations provide rapid assembly of five- and six-membered oxa- and carbocyclic nitriles demonstrating the utility of omega-halonitriles in domino alkylations...
  29. ncbi Zinc trimethylsilylamide as a mild ammonia equivalent and base for the amination of aryl halides and triflates
    Dae Yon Lee
    Department of Chemistry, Yale University, P O Box 208107, New Haven, Connecticut 6520 8107, USA
    Org Lett 7:1169-72. 2005
    ..In addition, aryl bromides coupled with aryl and alkylamines with the combination of Zn[N(SiMe(3))(2)](2) and LiCl as base. These aminations occurred without racemization of the enolizable stereocenter of an optically active ester...
  30. ncbi Palladium-catalyzed hydrocarbonation and hydroamination of 3,3-dihexylcyclopropene with pronucleophiles
    Itaru Nakamura
    Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980 8578, Japan
    J Org Chem 68:2297-9. 2003
    ....
  31. ncbi Ionic liquid as reagent. A green procedure for the regioselective conversion of epoxides to vicinal-halohydrins using [AcMIm]X under catalyst- and solvent-free conditions
    Brindaban C Ranu
    Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 032, India
    J Org Chem 70:4517-9. 2005
    ..The cleavages are considerably fast and highly regioselective...
  32. ncbi Reductive coupling of terpenic allylic halides catalyzed by Cp2TiCl: a short and efficient asymmetric synthesis of onocerane triterpenes
    Alejandro F Barrero
    Department of Organic Chemistry, Institute of Biotechnology, University of Granada, Avenida Fuentenueva, 18071 Granada, Spain
    Org Lett 7:2301-4. 2005
    ..This process has been employed in the short and effective synthesis of terpenoids such as beta-onoceradiene (1), beta-onocerin (2), and squalene (3). Evidence is presented for eta1-allyltitanium species being involved in the coupling...
  33. ncbi C10-substituted camphors and fenchones by electrophilic treatment of 2-methylenenorbornan-1-ols: enantiospecificity, scope, and limitations
    Santiago de la Moya Cerero
    Departamento de Quimica Organica I, Facultad de Ciencias Quimicas, Universidad Complutense de Madrid, Ciudad Universitaria, 28040 Madrid, Spain
    J Org Chem 68:1451-8. 2003
    ..The feasibility of the described methodology has been exemplified by the highly efficient enantiospecific preparation of several interesting C(10)-halogen-, C(10)-O-, C(10)-S-, C(10)-Se-, or C(10)-C-substituted camphors and fenchones...
  34. ncbi Pd-mBDPP-catalyzed regioselective internal arylation of electron-rich olefins by aryl halides
    Shifang Liu
    Department of Chemistry, Liverpool Centre for Materials and Catalysis, University of Liverpool, Liverpool L697ZD, UK
    J Org Chem 71:7467-70. 2006
    ..The better performance of mBDPP, compared with that of the commonly used DPPP [1,3-bis(diphenylphosphino)propane], highlights the important but subtle effect of ligand on the regioselectivity of the Heck arylation reactions...
  35. pmc Pd(OAc)(2)-catalyzed Domino reactions of 1-chloro-2-haloarenes and 2-haloaryl tosylates with hindered Grignard reagents via palladium-associated arynes
    Cheng Guo Dong
    Department of Chemistry, College of Staten Island and the Graduate Center of the City University of New York, Staten Island, NY 10314, USA
    Org Lett 8:5057-60. 2006
    ..reaction: see text]..
  36. ncbi Scope and mechanism of palladium-catalyzed amination of five-membered heterocyclic halides
    Mark W Hooper
    Department of Chemistry, P O Box 208107, Yale University, New Haven, Connecticut 06520 8107, USA
    J Org Chem 68:2861-73. 2003
    ..The fastest aminations of thiazoles, benzimidazoles, and benzoxazoles occurred with the combination of palladium trifluoroacetate and P(t)Bu(3) as catalyst...
  37. ncbi Simple copper salt-catalyzed N-arylation of nitrogen-containing heterocycles with aryl and heteroaryl halides
    Liangbo Zhu
    Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, West China Hospital, Sichuan University, Chengdu 610064, PR China
    J Org Chem 72:8535-8. 2007
    ..with aryl and heteroaryl halides have been developed. The protocols can be performed easily and tolerate a number of functional groups, such as ester, nitrile, nitro, ketone, free hydroxyl, and free primary amine on the aryl halide...
  38. pmc Orthogonal Pd- and Cu-based catalyst systems for C- and N-arylation of oxindoles
    Ryan A Altman
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 130:9613-20. 2008
    ..Computational examination of the relevant L1Pd(Ar)(oxindolate) and diamine-Cu(oxindolate) species was performed to gain mechanistic insight into the controlling features of the observed chemoselectivity...
  39. ncbi Enantioselective alkyl-alkyl Suzuki cross-couplings of unactivated homobenzylic halides
    Bunnai Saito
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 130:6694-5. 2008
    ..To the best of our knowledge, there are no previous examples of enantioselective Suzuki couplings of alkyl electrophiles (activated or unactivated). Both of the catalyst components are commercially available...
  40. ncbi Palladium-catalyzed carbene insertion and trapping with carbon nucleophiles
    Sean K J Devine
    Department of Chemistry, 1102 Natural Sciences, University of California, Irvine, California 92697 2025, USA
    Org Lett 10:1909-11. 2008
    ..The allylpalladium intermediate is attacked by the carbon nucleophile to generate a vinylsilane product...
  41. ncbi An improved Cu-based catalyst system for the reactions of alcohols with aryl halides
    Ryan A Altman
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Org Chem 73:284-6. 2008
    ..The relatively mild conditions, short reaction times, and moderately low catalyst loading allow for a wide array of functional groups to be tolerated on both the electrophilic and nucleophilic coupling partners...
  42. ncbi Differentially protected benzenediboronic acids: divalent cross-coupling modules for the efficient synthesis of boron-substituted oligoarenes
    Hiroyoshi Noguchi
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Kyoto 615 8510, Japan
    Org Lett 10:377-80. 2008
    ....
  43. ncbi C-C bond formation catalyzed heterogeneously by nickel-on-graphite (Ni/Cg)
    Bruce H Lipshutz
    Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA
    Org Lett 10:697-700. 2008
    ..Comparisons are made with the charcoal analogue, Ni/C, and some unusual chemoselectivities between these catalysts have been uncovered...
  44. doi Site-selective sp2 and benzylic sp3 palladium-catalyzed direct arylation
    Louis Charles Campeau
    Center for Catalysis Research and Innovation, University of Ottawa, Department of Chemistry, 10 Marie Curie, Ottawa, Ontario, Canada K1N 6N5
    J Am Chem Soc 130:3266-7. 2008
  45. ncbi Facile access to polysubstituted indoles via a cascade Cu-catalyzed arylation-condensation process
    Yu Chen
    Department of Chemistry, Fudan University, Shanghai, China
    J Org Chem 72:9329-34. 2007
    ..Polysubstituted indoles can be prepared from substituted 2-halotrifluoroacetanilides with high regioselectivity...
  46. ncbi Regioselective (site-selective) functionalization of unsaturated halogenated nitrogen, oxygen and sulfur heterocycles by Pd-catalysed cross-couplings and direct arylation processes
    Ian J S Fairlamb
    Department of Chemistry, University of York, Heslington, York, UK
    Chem Soc Rev 36:1036-45. 2007
    ..Direct arylation of electron-rich unsaturated heterocyclic compounds by C-H functionalization is also presented...
  47. ncbi Synthesis of n-heteroaryl-7-azabicyclo[2.2.1]heptane derivatives via palladium-bisimidazol-2-ylidene complex catalyzed amination reactions
    J Cheng
    Department of Chemistry, University of New Orleans, New Orleans, Louisiana 70148, USA
    Org Lett 3:1371-4. 2001
    ..2.1]heptane has been achieved. The cross-coupling amination reaction employs palladium-bisimidazol-2-ylidene complexes as catalysts to give good to moderate yields over a wide variety of substrates...
  48. ncbi Heterogeneous Pd/C-catalyzed ligand-free, room-temperature Suzuki-Miyaura coupling reactions in aqueous media
    Tomohiro Maegawa
    Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, Mitahora Higashi, Gifu 502 8585, Japan
    Chemistry 13:5937-43. 2007
    ....
  49. ncbi Palladium-catalyzed cross-coupling between vinyl halides and tert-butyl carbazate: first general synthesis of the unusual N-Boc-N-alkenylhydrazines
    José Barluenga
    Instituto Universitario de Quimica Organometalica Enrique Moles, Universidad de Oviedo, Julian Claveria 8, Oviedo 33006, Spain
    Org Lett 9:275-8. 2007
    ..The present methodology represents the first general way to access this highly functionalized and unusual type of hydrazines. [reaction: see text]...
  50. ncbi Synthesis of tricyclic heterocycles via a tandem aryl alkylation/heck coupling sequence
    Dino Alberico
    Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St George Street, Toronto, Ontario, M5S 3H6, Canada
    J Org Chem 72:775-81. 2007
    ..This approach was further applied to the synthesis of a tricyclic mescaline analogue...
  51. ncbi Regioselective synthesis of 1-alkyl- or 1-aryl-1H-indazoles via copper-catalyzed cyclizations of 2-haloarylcarbonylic compounds
    Dolores Viña
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, CIETUS, Campus Unamuno, 37007 Salamanca, Spain
    Org Lett 9:525-8. 2007
    ..Ligands commonly employed as catalysts for intermolecular amination were shown to be ineffective for this cyclization...
  52. ncbi New Heck-type reaction applied to the synthesis of protoporphyrin-IX derivatives
    M Castella
    , Universitat de Barcelona, , E-08028 Barcelona, Catalunya, Spain
    Org Lett 3:541-4. 2001
    ..This coupling reaction, although providing moderate regioselectivity, gives quantitative conversion...
  53. ncbi Comparative toxicity of polychlorinated biphenyls to Japanese quail (Coturnix c. japonica) and American kestrels (Falco sparverius)
    J E Elliott
    Canadian Wildlife Service, Environment Canada, National Wildlife Research Centre, Ottawa, Ontario, Canada
    J Toxicol Environ Health 51:57-75. 1997
    Polychlorinated biphenyls (PCBs) and related halogenated hydrocarbons bioaccumulate to high concentrations in top predators, such as raptorial birds, yet little is known of PCB toxicity to such species...
  54. ncbi Characterization of hydrocarbons, halocarbons and carbonyls in the atmosphere of Hong Kong
    H Guo
    Research Centre for Urban Environmental Technology and Management, Department of Civil and Structural Engineering, The Hong Kong Polytechnic University, Hung Hom Kowloon, Hong Kong
    Chemosphere 57:1363-72. 2004
    ..The BTEX ratios at CW and TW were 1.6:10.1:1.0:1.6 and 2.1:10.8:1.0:2.0, respectively. For major halogenated hydrocarbons, the mean concentrations of chloromethane, CFCs 12 and 22 did not show spatial variations at the two ..
  55. ncbi Volatile substance and other drug abuse inhalation in Spain
    María Fátima Ramón
    Servicio de Información Toxicológia, Instituto Nacional de Toxicologia, Madrid, Spain
    J Toxicol Clin Toxicol 41:931-6. 2003
    ..We reviewed retrospectively the cases of inhalant misuse reported to the Spanish Poison Control Center...
  56. ncbi Comparative oxidation and net emissions of methane and selected non-methane organic compounds in landfill cover soils
    Charlotte Schuetz
    Environment and Resources, Technical University of Denmark, DK 2800 Lyngby, Denmark
    Environ Sci Technol 37:5150-8. 2003
    ..The 37 NMOCs quantified in the landfill gas samples included alkanes (C1-C10), alkenes (C1-C4), halogenated hydrocarbons (including (H)CFCs), and aromatic hydrocarbons. Both positive and negative CH4 fluxes ranging from -0...
  57. ncbi Attenuation of methane and volatile organic compounds in landfill soil covers
    Charlotte Scheutz
    Environment and Resources, Bygningstorvet Building 115, Technical University of Denmark, DK 2800 Lyngby, Denmark
    J Environ Qual 33:61-71. 2004
    ..03 and 1.7 microg g(-1) h(-1). Fully halogenated hydrocarbons (PCE, tetrachloromethane [TeCM], chlorofluorocarbon [CFC]-11, CFC-12, and CFC-113) were not degraded in ..
  58. ncbi Polybrominated diphenyl ethers, polychlorinated dibenzo-dioxins, -furans, and -biphenyls in three species of Antarctic penguins
    Simonetta Corsolini
    Dipartimento di Scienze Ambientali G Sarfatti, University of Siena, 53100 Siena, Italy
    Environ Sci Pollut Res Int 14:421-9. 2007
    ..The potential toxicity of twenty-two dioxin-like congeners was assessed and expressed as 2,3,7,8-tetraCDD equivalents (TEQs). Differences between males and females were investigated...
  59. ncbi Chemical contamination of potable water in ship tanks
    Marcus Oldenburg
    Hamburg Port Health Center, Institute of Occupational and Maritime Medicine ZfAM, University of Hamburg, Germany
    Int Marit Health 58:79-91. 2007
    ..The aim of this study was to explore the frequency of drinking water contamination by chemicals in a selected sample of vessels and to assess the usefulness of recommended control measures...
  60. ncbi The cytochrome P-450 isoenzyme CYP2E1 in the biological processing of industrial chemicals: consequences for occupational and environmental medicine
    Hermann M Bolt
    Institut fur Arbeitsphysiologie, University of Dortmund, Ardeystrasse 67, 44139 Dortmund, Germany
    Int Arch Occup Environ Health 76:174-85. 2003
    ..a. alkanes, alkenes, aromatic and halogenated hydrocarbons)...
  61. ncbi Determination of volatile organic hydrocarbons in water samples by solid-phase dynamic extraction
    Maik A Jochmann
    Center for Applied Geoscience ZAG, Eberhard Karls Universitat Tubingen, Sigwartstr 10, 72076, Tubingen, Germany
    Anal Bioanal Chem 387:2163-74. 2007
    ..coupled to gas chromatography-mass spectrometry (HS-SPDE-GC/MS) for the trace determination of volatile halogenated hydrocarbons and benzene from groundwater samples was developed and evaluated...
  62. ncbi DNA damage induced by nitrous oxide: study in medical personnel of operating rooms
    Teresa Wronska-Nofer
    Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, 8 Teresy St, 91 348 Lodz, Poland
    Mutat Res 666:39-43. 2009
    Occupational exposure to anaesthetics such as nitrous oxide (N(2)O) and halogenated hydrocarbons has been suggested to increase risk of genetic damage...
  63. ncbi Neuroembryopathic effect of trichloroacetic acid in rats exposed during organogenesis
    Royana Singh
    Department of Anatomy, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
    Birth Defects Res B Dev Reprod Toxicol 77:47-52. 2006
    b>Halogenated hydrocarbons such as trichloroacetic acid (TCA) are among the most common water supply contaminants in the world. This study examines the effect of TCA on the developing brain of the Charles Foster rat.
  64. pmc Environmental chemical exposures and disturbances of heme synthesis
    W E Daniell
    Department of Environmental Health, University of Washington, Seattle 98195 7234, USA
    Environ Health Perspect 105:37-53. 1997
    ..A number of chemicals, particularly metals and halogenated hydrocarbons, induce disturbances of heme synthesis in experimental animals...
  65. ncbi A validated method for the quantitation of 1,1-difluoroethane using a gas in equilibrium method of calibration
    Joseph Avella
    Department of Pharmaceutical Sciences, St John s University, Jamaica, New York, USA
    J Anal Toxicol 32:680-7. 2008
    1,1-Difluoroethane (DFE), also known as Freon 152A, is a member of a class of compounds known as halogenated hydrocarbons. A number of these compounds have gained notoriety because of their ability to induce rapid onset of intoxication ..
  66. ncbi Binding of thiopental to human serum albumin in the presence of halogenated hydrocarbons and ethers
    U Buch
    Institut für Anästhesie, Universitat des Saarlandes, Homburg Saar, FRG
    Methods Find Exp Clin Pharmacol 12:53-60. 1990
    ..Other halogenated hydrocarbons such as chloroform (6.2.10(-3) M) and carbon tetrachloride (5.2...
  67. ncbi Purification and characterization of human kidney cytosolic cysteine conjugate beta-lyase activity
    L H Lash
    Department of Pharmacology, University of Rochester School of Medicine and Dentistry, NY
    Drug Metab Dispos 18:50-4. 1990
    The central role of cysteine conjugate beta-lyase (beta-lyase) in the bioactivation of nephrotoxic halogenated hydrocarbons and the possibility of human exposure to these chemicals has focused interest on the beta-lyase from human kidney...
  68. ncbi Atmospheric emissions and attenuation of non-methane organic compounds in cover soils at a French landfill
    C Scheutz
    Institute of Environment and Resources, Technical University of Denmark, Bygningstorvet Building 115, DK 2800 Lyngby, Denmark
    Waste Manag 28:1892-908. 2008
    ..may contain more than 200 non-methane organic compounds (NMOCs) including C(2+)-alkanes, aromatics, and halogenated hydrocarbons. Although the trace components make up less than 1% v/v of typical landfill gas, they may exert a ..
  69. ncbi Binding of polycyclic aromatic hydrocarbons (PAHs) to teleost aryl hydrocarbon receptors (AHRs)
    Sonya M Billiard
    Department of Biology, Queen s University, ON, Kingston, Canada
    Comp Biochem Physiol B Biochem Mol Biol 133:55-68. 2002
    ..that exposure of the early life stages of fish to PAH can mimic the embryotoxic effects of the planar halogenated hydrocarbons (PHHs), the most potent of which is 2,3,7,8-tetrachlorodibenzo-p-dioxin...
  70. ncbi The importance of hydrophobicity and electrophilicity descriptors in mechanistically-based QSARs for toxicological endpoints
    M T D Cronin
    School of Pharmacy and Chemistry, Liverpool John Moores University, UK
    SAR QSAR Environ Res 13:167-76. 2002
    ..aliphatic alcohols on the perfused rat liver; the toxicity of 21 pyridines to mice; the lethality of 55 halogenated hydrocarbons to the mould Aspergillus nidulans)...
  71. ncbi Disposition of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) in two Norwegian epibenthic marine food webs
    Anders Ruus
    Norwegian Institute for Water Research NIVA, P O Box 173, Kjelsas, N 0411 Oslo, Norway
    Chemosphere 62:1856-68. 2006
    Polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) are a group of halogenated hydrocarbons, comprising 210 different, theoretically possible congeners...
  72. ncbi Hydrocarbon toxicity: an analysis of AAPCC TESS data
    Daniel J Cobaugh
    American Society of Health System, Pharmacists Research and Education Foundation, Bethesda, MD, USA
    Przegl Lek 64:194-6. 2007
    ..To determine which hydrocarbons were associated with the most severe adverse outcomes, human exposure data reported to American poison information centers were analyzed...
  73. ncbi A case of acute toxic hepatitis after suicidal chloroform and dichloromethane ingestion
    Hoon Kim
    Department of Emergency Medicine, College of Medicine, Chungbuk National University, Chungbuk 361 763, South Korea
    Am J Emerg Med 26:1073.e3-6. 2008
    Chloroform and dichloromethane are halogenated hydrocarbons that have been used as a potent anesthetic agent or a general industrial solvent...
  74. ncbi Bioactivation of halogenated hydrocarbons by rabbit pulmonary cells
    W K Nichols
    Department of Pharmacology and Toxicology, University of Utah, Salt Lake City 84112
    Pharmacol Toxicol 71:335-9. 1992
    ..1,1-Dichloro-2,2-bis (4'-chlorophenyl)ethane (DDD), 1,2-dibromoethane (DBE) and trichloroethylene are three halogenated hydrocarbons that selectively bind to pulmonary epithelial cells and that may be pneumotoxic...
  75. ncbi Microbial signature lipid profiling and exopolysaccharides: experiences initiated with Professor David C White and transported to Tasmania, Australia
    Peter D Nichols
    CSIRO Marine and Atmospheric Research, CSIRO Food Futures Flagship, GPO Box 1538, Hobart, Tasmania 7000, Australia
    J Microbiol Methods 74:33-46. 2008
    ..of the DMDS procedure in taxonomic and environmental studies including the degradation of pollutant halogenated hydrocarbons in groundwater and subsurface aquifers; exploiting the ubiquitous nature of uronic acids in microbial EPS ..
  76. ncbi Factors affecting the storage and excretion of toxic lipophilic xenobiotics
    R J Jandacek
    The University of Cincinnati, Department of Pathology, Ohio 45267, USA
    Lipids 36:1289-305. 2001
    ..toxic materials have been the recent focus of international effort to reduce or eliminate classes of halogenated hydrocarbons from the environment...
  77. ncbi Is the white-ivory assay of Drosophila melanogaster a useful tool in genetic toxicology?
    J A Ferreiro
    Departamento de Biologia Funcional, Universidad de Oviedo, Spain
    Environ Mol Mutagen 29:406-17. 1997
    ..agents, DNA-topoisomerase inhibitors, antimetabolites/nucleotide pool inhibitors, cyclic-adduct inducers, halogenated hydrocarbons, bulky-adduct inducers, intercalating agents, oxidative damage inducers, and a multiple damage inducer, ..
  78. pmc Enhanced metabolism of halogenated hydrocarbons in transgenic plants containing mammalian cytochrome P450 2E1
    S L Doty
    Department of Biochemistry, Box 357350, and College of Forest Resources, Box 352100, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 97:6287-91. 2000
    ..Therefore, transgenic plants with this enzyme could be used for more efficient remediation of many sites contaminated with halogenated hydrocarbons.
  79. ncbi Occurrence of priority organic pollutants in the fertilizers, China
    Ce Hui Mo
    Department of Environmental Engineering, Jinan University, Guangzhou 510632, China
    J Hazard Mater 152:1208-13. 2008
    ..w.), followed by polycyclic aromatic hydrocarbons (PAHs; <140 microg kg(-1) d.w.) and halogenated hydrocarbons (<900 microg kg(-1) d.w.). Chlorobenzenes and haloethers occurred generally at low concentrations...
  80. ncbi Improved analysis of volatile halogenated hydrocarbons in water by purge-and-trap with gas chromatography and mass spectrometric detection
    Lelio Zoccolillo
    Dipartimento di Chimica, Universita degli Studi di Roma La Sapienza, Ple Aldo Moro 5, 00185 Rome, Italy
    J Chromatogr A 1077:181-7. 2005
    ..Our method has been successfully used on real samples: tap water, mineral water and Antarctic snow...
  81. ncbi [SIN survey on quality control of dialysis water in Italy]
    G Bonfant
    U O di Nefrologia e Dialisi, Ospedale di Aosta, Aosta, Italy
    G Ital Nefrol 22:241-5. 2005
    ..The importance of high quality water for dialysis is well established. This study aimed to obtain a picture of the Italian situation to develop national guidelines...
  82. ncbi Occurrence of organic contaminants in sewage sludges from eleven wastewater treatment plants, China
    Quan Ying Cai
    College of Resources and Environment, South China Agricultural University, Guangzhou, China
    Chemosphere 68:1751-62. 2007
    ..w.), respectively, followed by chlorobenzenes, nitroaromatics, haloethers and halogenated hydrocarbons which occurred generally at concentrations lower than 10mgkg(-1) d.w...
  83. ncbi Thinner intoxication manifesting as methemoglobinemia
    Sanjay Verma
    Department of Pediatrics UCMS and GTB Hospital, Delhi, India
    Indian J Pediatr 76:315-6. 2009
    ..commonly used for removing household paints is known to contain mixture of various arometic hydrocarbons; halogenated hydrocarbons and naptha, if ingested may rarely cause methemoglobinemia...
  84. ncbi Differential sensitivity of CYP1A to 3,3',4',4-tetrachlorobiphenyl and benzo(a)pyrene in two Lepomis species
    Ben F Brammell
    Department of Biology, University of Kentucky, Lexington, KY 40506, USA
    Comp Biochem Physiol C Toxicol Pharmacol 152:42-50. 2010
    ..be an excellent biomarker for PAH pollution, but may not be a reliable indicator of site contamination by halogenated hydrocarbons. We conclude that Lepomis species provide a useful model for examining the regulation and potential ..
  85. ncbi [The mutagenicity of organic microcontamination in the environment. II. The mutagenicity of volatile organic halogens in the Salmonella microsome test (Ames Test) with regard to the contamination of groundwater and drinking water]
    V Mersch Sundermann
    ,
    Zentralbl Bakteriol Mikrobiol Hyg B 187:230-43. 1989
    ..sensitivity and specificity of microbial shortterm-tests for the registration of the mutagenic potency of halogenated hydrocarbons (OHV) 18 pure substances out of the groups of halomethanes, -ethanes and -ethylenes were examined with ..
  86. ncbi Analysis of persistent halogenated hydrocarbons in fish feeds containing fish oil and other alternative lipid sources
    Jing You
    State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, China
    Talanta 85:1291-7. 2011
    A trade-off exists between beneficial n-3 long-chain polyunsaturated acids and toxic persistent halogenated hydrocarbons (PHHs), both of which primarily originate from fish oil commonly used in fish feeds...
  87. ncbi Immunohistochemical studies on early stage of hepatic damage induced by subacute inhalation of toluene vapor in rats
    Takako Gotohda
    Department of Forensic Medicine, Tokushima University School of Medicine, Kuramoto, Tokushima 770 8503, Japan
    J Appl Toxicol 29:505-9. 2009
    ..to be vulnerable and susceptible to various organic solvents, particularly chloroform and other halogenated hydrocarbons, the hepatotoxic effects of aromatic hydrocarbons including toluene have not yet been sufficiently ..
  88. ncbi The aryl hydrocarbon receptor, a basic helix-loop-helix transcription factor of the PAS gene family, is required for normal ovarian germ cell dynamics in the mouse
    R Robles
    Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston 02114, USA
    Endocrinology 141:450-3. 2000
    ..of the protein to bind with and be activated by polycyclic aromatic hydrocarbons (PAH) and related halogenated hydrocarbons, is part of an emerging family of ligand-activated transcriptional regulators that are distinct from the ..
  89. ncbi Environmental risk factors for mycosis fungoides
    Yonit Wohl
    Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Curr Probl Dermatol 35:52-64. 2007
    ..recent epidemiological data indicate that occupational exposure to chemicals, primarily to aromatic halogenated hydrocarbons, is a major risk factor to develop MF in men (odds ratio 4...
  90. pmc Potential exposure to PCBs, DDT, and PBDEs from sport-caught fish consumption in relation to breast cancer risk in Wisconsin
    Jane A McElroy
    University of Wisconsin Comprehensive Cancer Center, Madison, 53726, USA
    Environ Health Perspect 112:156-62. 2004
    ..PCBs), dichlorodiphenyltrichloroethane (DDT), polybrominated diphenyl ethers (PBDEs), and other halogenated hydrocarbons, all of which may act as potential risk factors for breast cancer...
  91. pmc Threshold of trichloroethylene contamination in maternal drinking waters affecting fetal heart development in the rat
    Paula D Johnson
    University Animal Care, University of Arizona, Tucson, Arizona, USA
    Environ Health Perspect 111:289-92. 2003
    b>Halogenated hydrocarbons such as trichloroethylene (TCE) are among the most common water supply contaminants in the United States and abroad...
  92. ncbi Relevance of the deletion polymorphisms of the glutathione S-transferases GSTT1 and GSTM1 in pharmacology and toxicology
    H M Bolt
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany
    Curr Drug Metab 7:613-28. 2006
    ..g. cytostatic drugs, hydrocarbons and halogenated hydrocarbons. GSTM1-1 is particularly relevant in the deactivation of carcinogenic intermediates of polycyclic ..
  93. ncbi Inhalation exposure in Drosophila mutagenesis assays: experiments with aliphatic halogenated hydrocarbons, with emphasis on the genetic activity profile of 1,2-dichloroethane
    P G Kramers
    National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands
    Mutat Res 252:17-33. 1991
    ..With compounds of intermediate volatility inhalation is not superior to other modes of administration; nor is it likely to be sensitive enough for in situ monitoring...
  94. ncbi Suicidal poisoning with mercaptodimethur-morphological findings and toxicological analysis
    A Thierauf
    Institute of Legal Medicine, Freiburg University Medical Centre, Albertstrasse 9, 79104 Freiburg, Germany
    Int J Legal Med 123:327-31. 2009
    ..agents has decreased to some extent due to laws restricting the use of highly toxic pesticides like halogenated hydrocarbons. Nevertheless, in consideration of the easy availability of most plant protectants, the small fraction of ..
  95. ncbi A motor vehicle accident fatality involving the inhalation of 1,1-difluoroethane
    Timothy Hahn
    Department of Forensic Toxicology, Division of Medical Legal and Forensic Investigations, Suffolk County, Hauppage, New York, USA
    J Anal Toxicol 30:638-42. 2006
    ..witnessed observation of the apparent impairing effects and consequences of the acute inhalation of halogenated hydrocarbons such as DFE and the operation of a motor vehicle...
  96. ncbi Three-block bi-focal PLS (3BIF-PLS) and its application in QSAR
    L Eriksson
    Umetrics AB, Umea, Sweden
    SAR QSAR Environ Res 15:481-99. 2004
    ..mutants of haloalkane dehalogenase from Sphingomonas paucimobilis UT26 and their ability to transform halogenated hydrocarbons, some of which are found as organic pollutants in soil...
  97. ncbi Metabolism-dependent activation and toxicity of chemicals in nasal glands
    E B Brittebo
    Department of Pharmaceutical Biosciences, Uppsala University, Sweden
    Mutat Res 380:61-75. 1997
    ..studies have demonstrated a selective covalent binding of nasal toxicants and carcinogens such as halogenated hydrocarbons and N-nitrosamines, especially in the Bowman's glands following a single systemic exposure, suggesting a ..
  98. ncbi Comparison of gas-solid chromatography and MM2 force field molecular binding energies for greenhouse gases on a carbonaceous surface
    Thomas R Rybolt
    Department of Chemistry, University of Tennessee at Chattanooga, Chattanooga, Tennessee 37403, United States
    J Colloid Interface Sci 338:287-92. 2009
    ..and prior Carbopack B adsorbates studied (linear alkanes, branched alkanes, cyclic alkanes, ethers, and halogenated hydrocarbons) gave a data set with 33 molecules and a regression of E(*)=0.991Ecal(*) and r(2)=0.968...
  99. ncbi Phospholipase A2 activation and cell injury in isolated rat hepatocytes exposed to bromotrichloromethane, chloroform, and 1,1-dichloroethylene as compared to effects of carbon tetrachloride
    E A Glende
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4970
    Toxicol Appl Pharmacol 113:159-62. 1992
    ..It is concluded that for these halogenated hydrocarbons phospholipase A2 activation may be part of the chain of causality leading from initial bioactivation to ..
  100. ncbi Volatile organic compound measurements in the California/Mexico border region during SCOS97
    B Zielinska
    Desert Research Institute, Reno, NV 89512, USA
    Sci Total Environ 276:19-31. 2001
    ..analyzed for speciated volatile hydrocarbons (C2-C12), CO, CO2, CH4, methyl t-butyl ether (MTBE), and halogenated hydrocarbons. DNPH-impregnated cartridges were analyzed for 14 C1-C7 carbonyl compounds...
  101. ncbi PBPK modeling of canine inhalation exposures to halogenated hydrocarbons
    A Vinegar
    ManTech Environmental Technology, Inc, P O Box 31009, Dayton, Ohio 45437, USA
    Toxicol Sci 60:20-7. 2001
    Human exposure guidelines for halogenated hydrocarbons (halons) and halon replacement chemicals have been established using dose-response data obtained from canine cardiac sensitization studies...

Research Grants54

  1. MOLECULAR MECHANISMS OF DIOXIN ACTION
    Alvaro Puga; Fiscal Year: 2013
    ..Our rationale is that mutations in the NKX2.5 gene and maternal exposure to halogenated hydrocarbons, dioxins and polychlorinated biphenyls during pregnancy are the main known risk factors for these human ..
  2. Transgenerational Inheritance of Epigenetic Effects of Polychlorinated Biphenyls
    Charles V Vorhees; Fiscal Year: 2013
    ..Similarly, maternal exposure during pregnancy to PCBs and other halogenated hydrocarbons has been associated with a higher incidence of congenital heart defects in the progeny and cardiac ..
  3. Antibacterial, antifungal, antiviral, and antispore paints
    YUYU contact SUN; Fiscal Year: 2011
    ..none corrosive, with no reported cases of microbial resistance, and have a much less tendency to generate halogenated hydrocarbons. In our technology, a new N-halamine monomer developed in our lab, N-chloro-2,2,6,6- tetramethyl-4-..
  4. Halogenated Alkenes and Microsomal GSH-transferases
    Michael J Kelner; Fiscal Year: 2010
    ..Unlike other halogenated hydrocarbons, vicinal haloalkenes uniquely damage the kidney by destroying proximal tubule cells and induce renal ..
  5. BIOACTIVATION OF HALOGENATED HYDROCARBONS
    F Peter Guengerich; Fiscal Year: 2013
    ..Collectively these studies should provide new mechanistic insight into the toxicity and carcinogenicity of these adducts and important information that may alter paradigms in risk assessment. ..
  6. Pesticide Exposures and Risk of Preterm Birth
    Gary M Shaw; Fiscal Year: 2013
    ..g., endocrine disruptors or developmental toxicants) and physiochemical groupings (e.g., carbamates, halogenated hydrocarbons, and arsenicals) of pesticides during pregnancy are associated with >100,000 women spontaneously ..
  7. HAZARDOUS WASTE RISK AND REMEDIATION IN THE SOUTHWEST
    Raina M Maier; Fiscal Year: 2013
    ..This is exemplified by the toxicants we study, metals (arsenic) and halogenated hydrocarbons, which are major contaminants in our region but also of significant concern throughout the world...
  8. FREE RADICAL LIPID PEROXIDATION DAMAGE
    ALOYS TAPPEL; Fiscal Year: 1991
    ..For screening initiators (halogenated hydrocarbons and peroxides) and antioxidants, thiobarbituric acid-reactive substances; release of ethane and pentane; ..
  9. Elucidating Risks: From Exposure and Mechanism to Outcome
    James A Swenberg; Fiscal Year: 2013
    ..we will focus on three major classes of chemicals ~ polycyclic aromatic hydrocarbons (PAHs), halogenated hydrocarbons, and heavy metals ~ in three biomedical and two non-biomedical projects, two Research Support Cores, a ..
  10. Particulate Methane Monooxygenase
    Amy C Rosenzweig; Fiscal Year: 2013
    ..In addition, methanotrophs can oxidize substrates besides methane, including halogenated hydrocarbons, and have been targeted for bioremediation applications...
  11. Antibiofilm tubing to reduce occupational exposure to biohazards in dentistry
    Yuyu Sun; Fiscal Year: 2009
    ..settings, but N-halamines are more stable, less corrosive, and have much less tendency to generate halogenated hydrocarbons. It is anticipated that after covalently binding N-halamines onto plastic tubes, the new tubes will be ..
  12. Toxicological Control Mechanisms of Human CYP1A2
    LINDA QUATTROCHI; Fiscal Year: 2004
    ..g. polycyclic aromatic hydrocarbons and halogenated hydrocarbons), dietary constituents (e.g. heterocyclic amines, flavones, indoles) and genetic factors...
  13. METABOLISM AND TOXICITY OF HALOGENATED HYDROCARBONS
    MARION ANDERS; Fiscal Year: 2004
    ..Abstract): The broad objective of the proposed research is to investigate the metabolism and toxicity of halogenated hydrocarbons. This competitive renewal application will be focused on the glutathione transferase zeta (GSTZ 1-1)-..
  14. METHANE OXIDATION BY METHANOTROPHS
    Mary Lidstrom; Fiscal Year: 1991
    ..a variety of non-growth substrates including straight-chain and cyclic hydrocarbons, as well as halogenated hydrocarbons. Since many of these compounds are toxic, it is of considerable interest to study this cooxidation ..
  15. Role of CYP2E1 and ADH in Human TRI Teratogenicity
    D McCarver; Fiscal Year: 2005
    Congenital heart disease is a major cause of mortality and morbidity. Exposure to halogenated hydrocarbons, specifically trichloroethylene (TRI), during pregnancy has been associated with congenital heart disease in animal models and ..
  16. INCREASE OF TOXICITY OF TRACE ANESTHETICS BY UV LIGHT
    JOANNES KARIS; Fiscal Year: 1980
    Ultraviolet irradiation is used in some operating rooms to decrease intraoperative wound infection. Halogenated hydrocarbons are commonly used as anesthetic agents and are known to undergo photodecomposition...
  17. DEVELOPMENT OF MITOTANE ANALOGS FOR ADRENAL CANCER
    David Schteingart; Fiscal Year: 1991
    ..studies with Mitotane and Mitometh and reports on the activation metabolism of p,p'-DDD and other halogenated hydrocarbons, we postulate that the adrenalytic action of Mitotane is linked to the ability of the dichloromethyl ..
  18. HUMAN METABOLISM OF HALOTHANE--MARKERS OF TOXIC EXPOSURE
    James Trudell; Fiscal Year: 1993
    ..The following experiments with halothane will also contribute to the understanding of how other halogenated hydrocarbons cause liver disease and cancer...
  19. HUMAN METABOLISM OF HALOTHANE-MECHANISMS OF TOXICITY
    James Trudell; Fiscal Year: 1990
    ..The following experiments with halothane will also contribute to the understanding of how other halogenated hydrocarbons cause liver disease and cancer...
  20. MECHANISM OF NEPHROTOXICITY OF ENVIRONMENTAL HALOCARBONS
    RICK SCHNELLMANN; Fiscal Year: 1991
    ..b>Halogenated hydrocarbons (HH) are a large group of chemicals known to produce nephrotoxicity...
  21. CELL CALCIUM, CALCIUM PUMP, AND TOXIN ACTION
    ALBERT MOORE; Fiscal Year: 1991
    ..examine the role of this increase of ionized calcium in the cytoplasm produced by exposure of the cell to halogenated hydrocarbons (carbon tetrachloride, 1, 1- dichloroethylene, bromobenzene)...
  22. MECHANISMS OF MUTAGENESIS BY CHEMICAL CARCINOGENS
    Patricia Foster; Fiscal Year: 1992
    ..2. To identify the major mutagenic lesions induced by halogenated hydrocarbons. The miscoding lesions demonstrated to be induced by 1,2-dibromoethane will be identified biochemically...
  23. SEPARATION AND DETERMINATION OF CARCINOGENS
    DONALD PIETRZYK; Fiscal Year: 1980
    ..For atmospheric sampling studies low molecular weight organic compounds, including benzene and halogenated hydrocarbons, will be studied...
  24. DETECTING ALKYL HALIDE MUTAGENICITY WITH ISOLATED DNA
    ANTHONY GARRO; Fiscal Year: 1980
    ..an assay system which will sensitively and reliably differentiate between mutagenic and non-mutagenic halogenated hydrocarbons. Many of the carcinogenic alkyl halides fail to exhibit mutagenic activity when assayed in the Salmonella ..
  25. Agilent 5973 GC/MS System
    GARY MOLANDER; Fiscal Year: 2002
    ..Our current lack of such instrumentation negatively affects the ability to carry out many of these studies. This critical capability, in the form of an instrument for everyday analysis, is urgently needed. ..
  26. Catalytic Processes for Selective Organic Synthesis
    GARY MOLANDER; Fiscal Year: 2005
    ..4) Carbometalation/cyclization reactions will be explored utilizing organochromium species. 5) Ligands and catalytic systems designed for asymmetric synthesis will be explored. ..
  27. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  28. Designing HTA therapy for drug resistant malaria
    Christian Wolf; Fiscal Year: 2009
    ..Our long term goal is the identification of novel, inexpensive, efficacious therapy for treating drug resistant malaria. ..
  29. STUDIES IN ALKALOID TOTAL SYNTHESIS
    STEVEN WEINREB; Fiscal Year: 2003
    ..In all of these projects a strong emphasis has been placed on developing new, practical methods of organic synthesis. ..
  30. Oxygen microscopy by two-photon excited phosphorescence
    Sergei Vinogradov; Fiscal Year: 2010
    ..The biological systems are selected to evaluate the performance of the technique and to simultaneously obtain valuable information for the related bio-medical problems. ..
  31. Cross-Coupling Reactions of Organosilanols
    SCOTT DENMARK; Fiscal Year: 2009
    ..Synthetic approaches to isodomoic acid H, hepatitis C viral inihibiting indole alkaloids, the salicylihalimide macrolactone oximidine II, and polyene antiviral antibiotic viridenomycin are detailed. ..
  32. ANESTHETIC RENAL METABOLISM--MECHANISMS AND CONSEQUENCES
    Evan Kharasch; Fiscal Year: 2002
    ..More broadly, resulting biochemical and clinical insights will be applicable to the numerous other nephrotoxic haloalkenes that are ubiquitous environmental contaminants. ..
  33. EPIDEMIC OCCUPATIONAL HEARING LOSS IN WASHINGTON STATE
    William Daniell; Fiscal Year: 2001
    ..OHL: (a) noise levels that exceed legal standards, (b) under-utilization of feasible noise controls, and (c) hearing conservation programs that are not compliant with legal standards and/or are not optimally effective? ..
  34. EARDA Transition: Further Enhance Faculty and Student R*
    Harpal Singh; Fiscal Year: 2005
    ..The administration enthusiastically supports, and is committed to the continuation of research development capability of faculty and students when EARDA funding concludes. ..
  35. FUSED HETEROCYCLES IN NATURAL PRODUCT SYNTHESIS
    Gordon Gribble; Fiscal Year: 2001
    ..A simple route to the as yet unisolable indole-2,3-quinodimethane is proposed that will lead to the isolation of this diene for the first time. ..
  36. IRON, ZINC AND FOLATE AND PRETERM DELIVERY
    David Savitz; Fiscal Year: 2001
    ..Although all are strongly suspected of influencing risk of preterm delivery, this study should provide evidence relevant to screening practice for infection and vitamin use during pregnancy. ..
  37. FINE TUNING BINOLS AND BINAPS FOR ASYMMETRIC SYNTHESIS
    Bruce Lipshutz; Fiscal Year: 2001
    ..From ligands of this type come further options, such as opportunities for polymer mounting, and potentially of greatest attention, conversion to substituted cyclo BINAPs. ..
  38. RECEPTOR MEDIATED OXIDATIVE STRESS
    HOWARD SHERTZER; Fiscal Year: 2003
    ..These studies will improve our understanding of how PHAHs such as TCDD generate oxidative stress and mutagenesis, leading to better models for risk assessment and novel strategies for intervention in PHAH-mediated toxicity. ..
  39. Novel noninvasive assessment of cytochrome P450 activity
    Evan Kharasch; Fiscal Year: 2009
    ..This approach may identify inter-individual variability in drug disposition and response;permit more individualized dosing, and reduces the cost of drug interaction studies. ..
  40. DENDRITIC O2 SENSOR WITH TWO-PHOTON ABSORBING ANTENNA
    Sergei Vinogradov; Fiscal Year: 2005
    ..If successful, these experiments will open avenues for novel research, which will span from the studies of protein conformations by small molecule diffusion to the construction of a single-molecule oxygen sensor. ..
  41. Cadmium Exposure and Breast Cancer Risk
    Jane McElroy; Fiscal Year: 2005
    ..The study team brings together expertise in breast cancer and environmental epidemiology, laboratory science, and biostatistics to efficiently address the role of cadmium in the etiology of breast cancer. ..
  42. Exogenous Stressors and Birth Defects Risks
    Suzan Carmichael; Fiscal Year: 2005
    ..This research will enhance scientific understanding of the causes of several common, costly, often deadly birth defects, which will undoubtedly have important implications for their risk assessment and prevention. ..
  43. EPIDEMIOLOGY OF EXERTION, STRESS, AND PRETERM DELIVERY
    David Savitz; Fiscal Year: 2004
    ..abstract_text> ..
  44. Honors Undergraduate Research Training at SSU
    Harpal Singh; Fiscal Year: 2006
    ..A mandatory Bioethics course is proposed for MARC participants. The SSU MARC program is a concerted approach to enlarge the pool of minority biomedical scientists. ..
  45. Tandem Cycloaddition Chemistry of 2-Azoniaheterodienes
    SCOTT DENMARK; Fiscal Year: 2007
    ..abstract_text> ..
  46. Metal-Mediated Routes to Biaryls
    Bruce Lipshutz; Fiscal Year: 2007
    ..A particular, albeit representative, application of a novel substituted cyclo-NOBIN will be studied for selected asymmetric aldol reactions. ..
  47. Chemical Studies on Anticancer Natural Products
    STEVEN WEINREB; Fiscal Year: 2007
    ..A total synthesis of the unusual cyclopropane-containing alkaloid lundurine A is in progress and will be completed, as will a new stereoselective total synthesis of the immunosuppressant agent FR901483. ..
  48. Glutathione in Environmental Toxicity and Disease
    HOWARD SHERTZER; Fiscal Year: 2007
    ..Our proposed research should therefore help focus future genotype-phenotype association studies between the appropriate DNA variant sites in the GCLC and GCLM genes and disease. ..
  49. The 17th Annual Conference of the International Society of Exposure of Analysis
    Clifford Weisel; Fiscal Year: 2007
    ..The primary outcome of the meeting will be the advancement of knowledge of human exposure science. [unreadable] [unreadable] [unreadable] [unreadable]..
  50. Radioimmunotherapy of CD20+ Lymphomas & CD45+Leukemias
    JOHN PAGEL; Fiscal Year: 2008
    ..abstract_text> ..
  51. General Anesthetics and nAcCHOR Agonist Affinity
    Douglas Raines; Fiscal Year: 2004
    ....