ethylenes

Summary

Summary: Derivatives of ethylene, a simple organic gas of biological origin with many industrial and biological use.

Top Publications

  1. pmc ETHYLENE RESPONSE FACTOR1 integrates signals from ethylene and jasmonate pathways in plant defense
    Oscar Lorenzo
    Departamento de Genética Molecular de Plantas, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, Campus Universidad Autonoma, 28049 Madrid, Spain
    Plant Cell 15:165-78. 2003
  2. ncbi Genome-wide insertional mutagenesis of Arabidopsis thaliana
    Jose M Alonso
    Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Science 301:653-7. 2003
  3. pmc Antagonistic interaction between abscisic acid and jasmonate-ethylene signaling pathways modulates defense gene expression and disease resistance in Arabidopsis
    Jonathan P Anderson
    Cooperative Research Centre for Tropical Plant Protection, University of Queensland, St Lucia, Queensland, 4072, Australia
    Plant Cell 16:3460-79. 2004
  4. ncbi Integration of plant responses to environmentally activated phytohormonal signals
    Patrick Achard
    John Innes Centre, Norwich NR4 7UJ, UK
    Science 311:91-4. 2006
  5. pmc Ethylene-inducible DNA binding proteins that interact with an ethylene-responsive element
    M Ohme-Takagi
    Plant Molecular Biology Laboratory, National Institute of Bioscience and Human Technology, Ibaraki, Japan
    Plant Cell 7:173-82. 1995
  6. ncbi Signal signature and transcriptome changes of Arabidopsis during pathogen and insect attack
    Martin De Vos
    Graduate School Experimental Plant Sciences, Section Phytopathology, Department of Biology, Utrecht Faculty of Science, Utrecht University, P O Box 800 84, 3508 TB Utrecht, The Netherlands
    Mol Plant Microbe Interact 18:923-37. 2005
  7. pmc Transcriptional profiling reveals novel interactions between wounding, pathogen, abiotic stress, and hormonal responses in Arabidopsis
    Yong Hwa Cheong
    Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, CA 94720, USA
    Plant Physiol 129:661-77. 2002
  8. pmc Nuclear events in ethylene signaling: a transcriptional cascade mediated by ETHYLENE-INSENSITIVE3 and ETHYLENE-RESPONSE-FACTOR1
    R Solano
    Department of Biology, Plant Science Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6018 USA
    Genes Dev 12:3703-14. 1998
  9. ncbi EIN2, a bifunctional transducer of ethylene and stress responses in Arabidopsis
    J M Alonso
    Plant Science Institute, Department of Biology, University of Pennsylvania, Philadelphia, PA 19104 6018, USA
    Science 284:2148-52. 1999
  10. ncbi Recent advances in ethylene research
    Zhefeng Lin
    Division of Plant and Crop Sciences, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UK
    J Exp Bot 60:3311-36. 2009

Detail Information

Publications265 found, 100 shown here

  1. pmc ETHYLENE RESPONSE FACTOR1 integrates signals from ethylene and jasmonate pathways in plant defense
    Oscar Lorenzo
    Departamento de Genética Molecular de Plantas, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, Campus Universidad Autonoma, 28049 Madrid, Spain
    Plant Cell 15:165-78. 2003
    ....
  2. ncbi Genome-wide insertional mutagenesis of Arabidopsis thaliana
    Jose M Alonso
    Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Science 301:653-7. 2003
    ..Insertion mutations were identified in genes that are regulated in response to the plant hormone ethylene...
  3. pmc Antagonistic interaction between abscisic acid and jasmonate-ethylene signaling pathways modulates defense gene expression and disease resistance in Arabidopsis
    Jonathan P Anderson
    Cooperative Research Centre for Tropical Plant Protection, University of Queensland, St Lucia, Queensland, 4072, Australia
    Plant Cell 16:3460-79. 2004
    ....
  4. ncbi Integration of plant responses to environmentally activated phytohormonal signals
    Patrick Achard
    John Innes Centre, Norwich NR4 7UJ, UK
    Science 311:91-4. 2006
    ..The growth restraint conferred by DELLA proteins is beneficial and promotes survival. We propose that DELLAs permit flexible and appropriate modulation of plant growth in response to changes in natural environments...
  5. pmc Ethylene-inducible DNA binding proteins that interact with an ethylene-responsive element
    M Ohme-Takagi
    Plant Molecular Biology Laboratory, National Institute of Bioscience and Human Technology, Ibaraki, Japan
    Plant Cell 7:173-82. 1995
    ..RNA gel blot analysis revealed that accumulation of mRNAs for EREBPs was induced by ethylene, but individual EREBPs exhibited different patterns of expression...
  6. ncbi Signal signature and transcriptome changes of Arabidopsis during pathogen and insect attack
    Martin De Vos
    Graduate School Experimental Plant Sciences, Section Phytopathology, Department of Biology, Utrecht Faculty of Science, Utrecht University, P O Box 800 84, 3508 TB Utrecht, The Netherlands
    Mol Plant Microbe Interact 18:923-37. 2005
    ....
  7. pmc Transcriptional profiling reveals novel interactions between wounding, pathogen, abiotic stress, and hormonal responses in Arabidopsis
    Yong Hwa Cheong
    Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, CA 94720, USA
    Plant Physiol 129:661-77. 2002
    ..These results further dissected the nature of mechanical wounding as a stress signal and identified new genes that may play a role in wounding and other signal transduction pathways...
  8. pmc Nuclear events in ethylene signaling: a transcriptional cascade mediated by ETHYLENE-INSENSITIVE3 and ETHYLENE-RESPONSE-FACTOR1
    R Solano
    Department of Biology, Plant Science Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6018 USA
    Genes Dev 12:3703-14. 1998
    ..The results demonstrate that the nuclear proteins EIN3 and ERF1 act sequentially in a cascade of transcriptional regulation initiated by ethylene gas...
  9. ncbi EIN2, a bifunctional transducer of ethylene and stress responses in Arabidopsis
    J M Alonso
    Plant Science Institute, Department of Biology, University of Pennsylvania, Philadelphia, PA 19104 6018, USA
    Science 284:2148-52. 1999
    ..EIN2 is thus recognized as a molecular link between previously distinct hormone response pathways. Plants may use a combinatorial mechanism for assessing various stresses by enlisting a common set of signaling molecules...
  10. ncbi Recent advances in ethylene research
    Zhefeng Lin
    Division of Plant and Crop Sciences, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UK
    J Exp Bot 60:3311-36. 2009
    ....
  11. ncbi AtNAC2, a transcription factor downstream of ethylene and auxin signaling pathways, is involved in salt stress response and lateral root development
    Xin Jian He
    National Key Lab of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Plant J 44:903-16. 2005
    ..AtNAC2 also promoted or inhibited downstream gene expressions. These results indicate that AtNAC2 may be a transcription factor incorporating the environmental and endogenous stimuli into the process of plant lateral root development...
  12. pmc The WRKY70 transcription factor: a node of convergence for jasmonate-mediated and salicylate-mediated signals in plant defense
    Jing Li
    Department of Biosciences, Division of Genetics, University of Helsinki, FIN 00014 Helsinki, Finland
    Plant Cell 16:319-31. 2004
    ..We suggest that WRKY70 acts as an activator of SA-induced genes and a repressor of JA-responsive genes, integrating signals from these mutually antagonistic pathways...
  13. pmc Multilevel interactions between ethylene and auxin in Arabidopsis roots
    Anna N Stepanova
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Plant Cell 19:2169-85. 2007
    ..This model not only implies existence of several levels of interaction but also provides a likely explanation for the strong ethylene response defects observed in auxin mutants...
  14. ncbi The ethylene response factors SNORKEL1 and SNORKEL2 allow rice to adapt to deep water
    Yoko Hattori
    Bioscience and Biotechnology Center, Nagoya University, Nagoya 464 8601, Japan
    Nature 460:1026-30. 2009
    ..This discovery will contribute to rice breeding in lowland areas that are frequently flooded during the rainy season...
  15. ncbi TAA1-mediated auxin biosynthesis is essential for hormone crosstalk and plant development
    Anna N Stepanova
    Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA
    Cell 133:177-91. 2008
    ..Thus, the IPA route of auxin production is key to generating robust auxin gradients in response to environmental and developmental cues...
  16. ncbi Sub1A is an ethylene-response-factor-like gene that confers submergence tolerance to rice
    Kenong Xu
    Department of Plant Pathology, University of California, Davis, California 95616, USA
    Nature 442:705-8. 2006
    ..Cultivation of this variety is expected to provide protection against damaging floods and increase crop security for farmers...
  17. ncbi Cross talk between signaling pathways in pathogen defense
    Barbara N Kunkel
    Department of Biology, Washington University, Campus Box 1137, 1 Brookings Drive, St Louis, Missouri 63130, USA
    Curr Opin Plant Biol 5:325-31. 2002
    ..The SA and JA signaling pathways are mutually antagonistic. This regulatory cross talk may have evolved to allow plants to fine-tune the induction of their defenses in response to different plant pathogens...
  18. pmc Ethylene biosynthesis and signaling networks
    Kevin L C Wang
    Plant Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Plant Cell 14:S131-51. 2002
  19. pmc Phosphorylation of 1-aminocyclopropane-1-carboxylic acid synthase by MPK6, a stress-responsive mitogen-activated protein kinase, induces ethylene biosynthesis in Arabidopsis
    Yidong Liu
    Department of Biochemistry, University of Missouri, Columbia, Missouri 65211, USA
    Plant Cell 16:3386-99. 2004
    ..Equally important, this study uncovers a signaling pathway that modulates the biosynthesis of ethylene, an important plant hormone, in plants under stress...
  20. pmc Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signalling
    Sang Dong Yoo
    Department of Molecular Biology, Massachusetts General Hospital, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 451:789-95. 2008
    ..The results suggest a new paradigm for linking intertwined MAPK cascades to control quantitative responses and specificity in signalling networks...
  21. ncbi Ethylene responses are negatively regulated by a receptor gene family in Arabidopsis thaliana
    J Hua
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Cell 94:261-71. 1998
    ....
  22. ncbi Constitutive expression of ETHYLENE-RESPONSE-FACTOR1 in Arabidopsis confers resistance to several necrotrophic fungi
    Marta Berrocal-Lobo
    Laboratorio de Bioquimica y Biologia Molecular, Departamento de Biotecnología UPM, ETS Ingenieros Agronomos, 28040 Madrid, Spain
    Plant J 29:23-32. 2002
    ....
  23. pmc Jasmonate signaling: toward an integrated view
    Kemal Kazan
    Commonwealth Scientific and Industrial Research Organization Plant Industry, Queensland Bioscience Precinct, St Lucia, Queensland 4067, Australia
    Plant Physiol 146:1459-68. 2008
  24. ncbi Ethylene biosynthesis and action in tomato: a model for climacteric fruit ripening
    Lucille Alexander
    Plant Science Division, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UK
    J Exp Bot 53:2039-55. 2002
    ....
  25. ncbi Molecular players regulating the jasmonate signalling network
    Oscar Lorenzo
    Departamento de Genética Molecular de Plantas, Centro Nacional de Biotecnologia CSIC, Campus Universidad Autonoma, 28049 Madrid, Spain
    Curr Opin Plant Biol 8:532-40. 2005
    ....
  26. pmc Ethylene modulates the role of NONEXPRESSOR OF PATHOGENESIS-RELATED GENES1 in cross talk between salicylate and jasmonate signaling
    Antonio Leon-Reyes
    Plant Microbe Interactions, Department of Biology, Faculty of Science, Utrecht University, 3508 TB Utrecht, The Netherlands
    Plant Physiol 149:1797-809. 2009
    ..Our results suggest a model in which ET modulates the NPR1 dependency of SA-JA antagonism, possibly to compensate for enhanced allocation of NPR1 to function in SA-dependent activation of PR genes...
  27. ncbi Activation of the ethylene gas response pathway in Arabidopsis by the nuclear protein ETHYLENE-INSENSITIVE3 and related proteins
    Q Chao
    Department of Biology, Plant Science Institute, University of Pennsylvania, Philadelphia 19104 6018, USA
    Cell 89:1133-44. 1997
    ..Overexpression of EIN3 or EIL1 in wild-type or ethylene-insensitive2 plants conferred constitutive ethylene phenotypes, indicating their sufficiency for activation of the pathway in the absence of ethylene...
  28. ncbi Biochemical and functional analysis of CTR1, a protein kinase that negatively regulates ethylene signaling in Arabidopsis
    Yafan Huang
    Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA
    Plant J 33:221-33. 2003
    ..These results suggest that CTR1 interacts with ETR1 in vivo, and that this association is required to turn off the ethylene-signaling pathway...
  29. pmc Repressor- and activator-type ethylene response factors functioning in jasmonate signaling and disease resistance identified via a genome-wide screen of Arabidopsis transcription factor gene expression
    Ken C McGrath
    Cooperative Research Centre for Tropical Plant Protection, University of Queensland, St Lucia, Australia
    Plant Physiol 139:949-59. 2005
    ..Our results suggest that plants coordinately express multiple repressor- and activator-type AP2/ERFs during pathogen challenge to modulate defense gene expression and disease resistance...
  30. pmc Genome-wide transcriptional analysis of grapevine berry ripening reveals a set of genes similarly modulated during three seasons and the occurrence of an oxidative burst at vèraison
    Stefania Pilati
    Department of Genetics and Molecular Biology IASMA Research Center, Via E, Mach 1, 38010 S, Michele a Adige TN, Italy
    BMC Genomics 8:428. 2007
    ..Despite this relevance, little is known about the transcriptional changes and the regulatory circuits underlying the biochemical and physical changes occurring during berry development...
  31. ncbi Ethylene: a gaseous signal molecule in plants
    A B Bleecker
    Departments of Botany and Genetics, University of Wisconsin, Madison, Wisconsin 53706 1381, USA
    Annu Rev Cell Dev Biol 16:1-18. 2000
    ..Biotechnological modifications of ethylene synthesis and of sensitivity to ethylene are promising methods to prevent spoilage of agricultural products such as fruits, whose ripening is induced by ethylene...
  32. ncbi AUXIN RESPONSE FACTOR1 and AUXIN RESPONSE FACTOR2 regulate senescence and floral organ abscission in Arabidopsis thaliana
    Christine M Ellis
    Department of Biology, University of North Carolina at Chapel Hill, CB 3280, Coker Hall, Chapel Hill, NC 27599 3280, USA
    Development 132:4563-74. 2005
    ..NPH4/ARF7 and ARF19 function as transcriptional activators, suggesting that auxin may control senescence in part by activating gene expression...
  33. ncbi A MADS-box gene necessary for fruit ripening at the tomato ripening-inhibitor (rin) locus
    Julia Vrebalov
    U S Department of Agriculture Agricultural Research Service USDA ARS Plant, Soil and Nutrition Lab and Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, NY 14853, USA
    Science 296:343-6. 2002
    ..LeMADS-RIN demonstrates an agriculturally important function of plant MADS-box genes and provides molecular insight into nonhormonal (developmental) regulation of ripening...
  34. ncbi Modulation of plant ethylene levels by the bacterial enzyme ACC deaminase
    Bernard R Glick
    Department of Biology, University of Waterloo, Waterloo, Ont, Canada N2L 3G1
    FEMS Microbiol Lett 251:1-7. 2005
    ..Here, the biochemistry of ACC deaminase; the environmental distribution, regulation, evolution and expression of ACC deaminase genes; and information regarding the effect of this enzyme on different plants is documented and discussed...
  35. pmc Phosphate availability alters architecture and causes changes in hormone sensitivity in the Arabidopsis root system
    José López-Bucio
    Departamento de Ingeniería Genética de Plantas, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Unidad Irapuato, Apartado Postal 629, 36500 Irapuato, Guanajuato, Mexico
    Plant Physiol 129:244-56. 2002
    ..These results suggest that in Arabidopsis, auxin sensitivity may play a fundamental role in the modifications of root architecture by P availability...
  36. pmc Mechanisms of cross talk between gibberellin and other hormones
    David Weiss
    Robert H Smith Institute of Plant Sciences and Genetics in Agriculture, Faculty of Agricultural, Food and Environmental Quality Sciences, Hebrew University of Jerusalem, Rehovot, Israel
    Plant Physiol 144:1240-6. 2007
  37. pmc Ethylene signaling: new levels of complexity and regulation
    Mandy D Kendrick
    Department of Cell Biology and Molecular Genetics, Bioscience Research Building, University of Maryland, College Park, MD 20742, USA
    Curr Opin Plant Biol 11:479-85. 2008
    ..Additionally, EIN3 possesses two mitogen-activated protein kinase (MAPK) phosphorylation sites that have opposing effects on EIN3 stability...
  38. ncbi Ripening of fleshy fruit: molecular insight and the role of ethylene
    Vishwas A Bapat
    Department of Biotechnology, Shivaji University, Kolhapur 416 004, India
    Biotechnol Adv 28:94-107. 2010
    ..Role of ethylene and ethylene-responsive genes in ripening of fleshy fruit is also included. Taking clues from the studies in tomato as a model fruit, few case studies are reviewed...
  39. ncbi Molecular aspects of seed dormancy
    Ruth Finkelstein
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, California 93106 9610, USA
    Annu Rev Plant Biol 59:387-415. 2008
    ..The net result is a slightly heterogeneous response, thereby providing more temporal options for successful germination...
  40. pmc Fleshy fruit expansion and ripening are regulated by the Tomato SHATTERPROOF gene TAGL1
    Julia Vrebalov
    Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, New York 14853, USA
    Plant Cell 21:3041-62. 2009
    ..From this broad perspective, SHP1/2 and TAGL1, while distinct in molecular function, regulate similar activities via their necessity for seed dispersal in Arabidopsis and tomato, respectively...
  41. pmc EIR1, a root-specific protein involved in auxin transport, is required for gravitropism in Arabidopsis thaliana
    C Luschnig
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142 1479 USA
    Genes Dev 12:2175-87. 1998
    ..Expression of the EIR1 gene in Saccharomyces cerevisiae confers resistance to fluorinated indolic compounds. Taken together, these data suggest that the EIR1 protein has a root-specific role in the transport of auxin...
  42. pmc Antagonistic interaction between systemic acquired resistance and the abscisic acid-mediated abiotic stress response in Arabidopsis
    Michiko Yasuda
    Plant Acquired Immunity Research Unit, Advanced Science Institute, RIKEN, Wako, Saitama 351 0198, Japan
    Plant Cell 20:1678-92. 2008
    ..Therefore, our data have revealed that antagonistic crosstalk occurs at multiple steps between the SA-mediated signaling of SAR induction and the ABA-mediated signaling of environmental stress responses...
  43. pmc ARABIDOPSIS DEHISCENCE ZONE POLYGALACTURONASE1 (ADPG1), ADPG2, and QUARTET2 are Polygalacturonases required for cell separation during reproductive development in Arabidopsis
    Mikihiro Ogawa
    CSIRO Plant Industry, Private Mail Bag, Merbein, Victoria 3505, Australia
    Plant Cell 21:216-33. 2009
    ..These results demonstrate that multiple cell separation events, including both abscission and dehiscence, require closely related PG genes...
  44. ncbi Dominant repression of target genes by chimeric repressors that include the EAR motif, a repression domain, in Arabidopsis
    Keiichiro Hiratsu
    Gene Function Research Laboratory, National Institute of Advanced Industrial Science and Technology AIST, Central 6, Tsukuba 305 8566, Japan
    Plant J 34:733-9. 2003
    ....
  45. ncbi Plant responses to ethylene gas are mediated by SCF(EBF1/EBF2)-dependent proteolysis of EIN3 transcription factor
    Hongwei Guo
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cell 115:667-77. 2003
    ..These results reveal that a ubiquitin/proteasome pathway negatively regulates ethylene responses by targeting EIN3 for degradation, and pinpoint EIN3 regulation as the key step in the response to ethylene...
  46. ncbi Convergence of signaling pathways in the control of differential cell growth in Arabidopsis
    Hai Li
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037 USA
    Dev Cell 7:193-204. 2004
    ....
  47. ncbi Paradigms and paradox in the ethylene signaling pathway and interaction network
    Qiong Zhao
    State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing 100871, China
    Mol Plant 4:626-34. 2011
    ....
  48. pmc The mitogen-activated protein kinase cascade MKK3-MPK6 is an important part of the jasmonate signal transduction pathway in Arabidopsis
    Fuminori Takahashi
    Gene Discovery Research Group, RIKEN Plant Science Center, Tsukuba, Ibaraki 305 0074, Japan
    Plant Cell 19:805-18. 2007
    ..We provide a model explaining how MPK6 can convert three distinct signals - JA, pathogen, and cold/salt stress - into three different sets of responses in Arabidopsis...
  49. pmc A novel signaling pathway controlling induced systemic resistance in Arabidopsis
    C M Pieterse
    Section of Plant Pathology, Department of Plant Ecology and Evolutionary Biology, Utrecht University, Sorbonnelaan 16, 3584 CA, Utrecht, The Netherlands
    Plant Cell 10:1571-80. 1998
    ....
  50. ncbi Ethylene signalling and ethylene-targeted transcription factors are required to balance beneficial and nonbeneficial traits in the symbiosis between the endophytic fungus Piriformospora indica and Arabidopsis thaliana
    Iris Camehl
    Friedrich Schiller Universitat Jena, Institut für Allgemeine Botanik und Pflanzenphysiologie, Jena, Germany
    New Phytol 185:1062-73. 2010
    ..The results show that the restriction of fungal growth by ethylene signalling components is required for the beneficial interaction between the two symbionts...
  51. pmc The role of ethylene and cold temperature in the regulation of the apple POLYGALACTURONASE1 gene and fruit softening
    Emma Tacken
    New Zealand Institute of Plant and Food Research, Auckland 1142, New Zealand
    Plant Physiol 153:294-305. 2010
    ....
  52. ncbi The ethylene signaling pathway: new insights
    Hongwei Guo
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Curr Opin Plant Biol 7:40-9. 2004
    ....
  53. pmc The role of ABA in triggering ethylene biosynthesis and ripening of tomato fruit
    Mei Zhang
    College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, PR China
    J Exp Bot 60:1579-88. 2009
    ....
  54. ncbi Different plant hormones regulate similar processes through largely nonoverlapping transcriptional responses
    Jennifer L Nemhauser
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cell 126:467-75. 2006
    ..Instead, different hormones appear to regulate distinct members of protein families. We conclude that there is not a core transcriptional growth-regulatory module in young Arabidopsis seedlings...
  55. ncbi Cytokinin and auxin inhibit abscisic acid-induced stomatal closure by enhancing ethylene production in Arabidopsis
    Yoko Tanaka
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwanoha, Kashiwa, Chiba 277 8562, Japan
    J Exp Bot 57:2259-66. 2006
    ..The above observations suggest that cytokinins and auxins inhibit ABA-induced stomatal closure through the modulation of ethylene biosynthesis, and that ethylene inhibits the ABA-induced reduction of osmotic pressure in the guard cells...
  56. ncbi A conditionally fertile coi1 allele indicates cross-talk between plant hormone signalling pathways in Arabidopsis thaliana seeds and young seedlings
    Christine Ellis
    School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK
    Planta 215:549-56. 2002
    ..We have used coi1-16 seeds to define novel interactions between JA and other hormone signalling pathways in seed germination and in the development of young seedlings...
  57. ncbi Hormone interactions in stomatal function
    Biswa R Acharya
    Biology Department, Pennsylvania State University, 208 Mueller Laboratory, University Park, PA 16802, USA
    Plant Mol Biol 69:451-62. 2009
    ..Here, we discuss the roles of different phytohormones and the effects of their interactions on guard cell physiology and function...
  58. ncbi MAPMAN: a user-driven tool to display genomics data sets onto diagrams of metabolic pathways and other biological processes
    Oliver Thimm
    Max Planck Institute for Molecular Plant Physiology, Golm, Germany
    Plant J 37:914-39. 2004
    ....
  59. ncbi Ethylene signaling and response: where different regulatory modules meet
    Anna N Stepanova
    Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA
    Curr Opin Plant Biol 12:548-55. 2009
    ..Tissue-specific regulation of auxin biosynthesis, transport, and response by ethylene is emerging as a key element in this signal integration process...
  60. ncbi HRE1 and HRE2, two hypoxia-inducible ethylene response factors, affect anaerobic responses in Arabidopsis thaliana
    Francesco Licausi
    Plant Lab, Scuola Superiore Sant Anna, Piazza Martiri della Libertà 33, 56127 Pisa, Italy
    Plant J 62:302-15. 2010
    ..We propose that HRE1 and HRE2 play a partially redundant role in low oxygen signalling in Arabidopsis thaliana, thus improving the tolerance of the plant to the stress by enhancing anaerobic gene expression and ethanolic fermentation...
  61. pmc Regulation of root hair initiation and expansin gene expression in Arabidopsis
    Hyung Taeg Cho
    Department of Biology, Pennsylvania State University, 208 Mueller Laboratory, University Park, Pennsylvania 16802, USA
    Plant Cell 14:3237-53. 2002
    ..Our study suggests that two distinctive signaling pathways, one developmental and the other environmental/hormonal, converge to modulate the initiation of the root hair and the expression of its specific expansin gene set...
  62. ncbi Arabidopsis MAP kinase 4 regulates salicylic acid- and jasmonic acid/ethylene-dependent responses via EDS1 and PAD4
    Peter Brodersen
    Institute of Molecular Biology, Copenhagen University, Øster Farimagsgade 2A, DK 1353 Copenhagen K, Denmark
    Plant J 47:532-46. 2006
    ..The regulation of some, but not all, of these genes involves EDS1 and PAD4...
  63. ncbi Auxin and ethylene: collaborators or competitors?
    Gloria K Muday
    Department of Biology, Wake Forest University, Winston Salem, NC 27106, USA
    Trends Plant Sci 17:181-95. 2012
    ..The emerging trend from these experiments is that ethylene modulates auxin synthesis, transport, and signaling with unique targets and responses in a range of tissues to fine-tune seedling growth and development...
  64. pmc Protection against heat stress-induced oxidative damage in Arabidopsis involves calcium, abscisic acid, ethylene, and salicylic acid
    Jane Larkindale
    Department of Plant Sciences, University of Oxford, South Parks Road, Oxford OX1 3RB, United Kingdom
    Plant Physiol 128:682-95. 2002
    ..Calcium channel blockers and calmodulin inhibitors added solely during the recovery phase suggest that this role for calcium is in protecting against oxidative damage specifically during/after recovery...
  65. ncbi Ethylene-auxin interactions regulate lateral root initiation and emergence in Arabidopsis thaliana
    Maria G Ivanchenko
    Department of Botany and Plant Pathology, 2082 Cordley Hall, Oregon State University, Corvallis, OR 97331, USA
    Plant J 55:335-47. 2008
    ....
  66. pmc The regulation of MADS-box gene expression during ripening of banana and their regulatory interaction with ethylene
    Tomer Elitzur
    Department of Postharvest Science of Fresh Produce, Agricultural Research Organization ARO, The Volcani Center, PO Box 6, Bet Dagan 50250, Israel
    J Exp Bot 61:1523-35. 2010
    ..Hence, our results are consistent with MaMADS2, a SEP3 homologue, acting in the pulp upstream of the increase in ethylene production similarly to LeMADS-RIN...
  67. ncbi The involvement of auxin in the ripening of climacteric fruits comes of age: the hormone plays a role of its own and has an intense interplay with ethylene in ripening peaches
    Livio Trainotti
    Dipartimento di Biologia, Universita di Padova, Via G Colombo 3, I 35131 Padova, Italy
    J Exp Bot 58:3299-308. 2007
    ..This study has also demonstrated the existence of an important cross-talk between auxin and ethylene, with genes in the auxin domain regulated by ethylene and genes in the ethylene domain regulated by auxin...
  68. pmc Modulation of ethylene responses affects plant salt-stress responses
    Wan Hong Cao
    National Key Lab of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Plant Physiol 143:707-19. 2007
    ..6. In addition, the transgene NTHK1 mRNA was accumulated under salt stress, suggesting a posttranscriptional regulatory mechanism. These findings imply that ethylene signaling may be required for plant salt tolerance...
  69. ncbi Plant hormones and nutrient signaling
    Vicente Rubio
    Department of Plant Molecular Genetics, Centro Nacional de Biotecnologia CSIC, Campus Universidad Autonoma de Madrid, 28049 Cantoblanco, Madrid, Spain
    Plant Mol Biol 69:361-73. 2009
    ....
  70. pmc Emerging connections in the ethylene signaling network
    Sang Dong Yoo
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Trends Plant Sci 14:270-9. 2009
    ....
  71. pmc The role of ethylene and wound signaling in resistance of tomato to Botrytis cinerea
    Jose Diaz
    Wageningen University Plant Sciences, Laboratory of Phytopathology, Binnenhaven 5, P O Box 8025, 6700 EE, Wageningen, The Netherlands
    Plant Physiol 129:1341-51. 2002
    ..Ethylene and wound signaling acted independently on resistance. Salicylate and ethylene acted synergistically on defense gene expression, but antagonistically on resistance...
  72. ncbi Genetic dissection of the role of ethylene in regulating auxin-dependent lateral and adventitious root formation in tomato
    Sangeeta Negi
    Department of Biology, Wake Forest University, Room 226 Winston Hall, Box 7325, Winston Salem, NC 27109, USA
    Plant J 61:3-15. 2010
    ..These results indicate a negative role for ethylene in lateral root formation and a positive role in adventitious root formation with modulation of auxin transport as a central point of ethylene-auxin crosstalk...
  73. ncbi A tomato (Solanum lycopersicum) APETALA2/ERF gene, SlAP2a, is a negative regulator of fruit ripening
    Mi Young Chung
    Boyce Thompson Institute for Plant Research, Tower Road, Cornell University Campus, Ithaca, NY 14853, USA
    Plant J 64:936-47. 2010
    ..These results suggest that SlAP2a functions during normal tomato fruit ripening as a modulator of ripening activity and acts to balance the activities of positive ripening regulators...
  74. ncbi Identification, phylogeny, and transcript profiling of ERF family genes during development and abiotic stress treatments in tomato
    Manoj K Sharma
    Department of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110021, India
    Mol Genet Genomics 284:455-75. 2010
    ..Results suggest that ERF genes play diverse roles in plant's life and comprehensive data generated will be helpful in conducting functional genomics studies to understand their precise role during plant development and stress response...
  75. pmc Interplay between ethylene, ETP1/ETP2 F-box proteins, and degradation of EIN2 triggers ethylene responses in Arabidopsis
    Hong Qiao
    Plant Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Genes Dev 23:512-21. 2009
    ..Thus, these studies reveal that a complex interplay between ethylene, the regulation of ETP1/ETP2 F-box proteins, and subsequent targeting and degradation of EIN2 is essential for triggering ethylene responses in plants...
  76. pmc Co-ordination of early and late ripening events in apples is regulated through differential sensitivities to ethylene
    Jason W Johnston
    The New Zealand Institute for Plant and Food Research Limited, Private Bag 92169, Auckland, New Zealand
    J Exp Bot 60:2689-99. 2009
    ..These results suggest a conceptual model for the control of individual ripening characters in apple, based on both ethylene dependency and sensitivity...
  77. pmc The response regulator 2 mediates ethylene signalling and hormone signal integration in Arabidopsis
    Claudia Hass
    Botanisches Institut, Universitat zu Koln, Koln, Germany
    EMBO J 23:3290-302. 2004
    ....
  78. pmc The Arabidopsis mutant cev1 has constitutively active jasmonate and ethylene signal pathways and enhanced resistance to pathogens
    C Ellis
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, United Kingdom
    Plant Cell 13:1025-33. 2001
    ..We conclude that cev1 stimulates both the JA and the ethylene signal pathways and that CEV1 regulates an early step in an Arabidopsis defense pathway...
  79. pmc Genetic regulation of fruit development and ripening
    James J Giovannoni
    United States Department of Agriculture Agricultural Research Service Plant, Soil, and Nutrition Laboratory and Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, New York 14853, USA
    Plant Cell 16:S170-80. 2004
  80. pmc A MAPK pathway mediates ethylene signaling in plants
    Fatma Ouaked
    Gregor Mendel Institute of Molecular Plant Sciences and Institute of Microbiology and Genetics, Vienna Biocenter, University of Vienna, Dr Bohrgasse 9, A 1030 Vienna, Austria
    EMBO J 22:1282-8. 2003
    ..In contrast, ctr1 mutants showed constitutive activation of MPK6. These data indicate that a MAPK cascade is part of the ethylene signal transduction pathway in plants...
  81. ncbi Differential regulation of EIN3 stability by glucose and ethylene signalling in plants
    Shuichi Yanagisawa
    Research Institute for Bioresources, Okayama University, Chuo 2 20 1, Kurashiki 710 0046, Japan
    Nature 425:521-5. 2003
    ..Ethylene, by contrast, enhances the stability of EIN3. The ein3 mutant has a glo phenotype, and overexpression of EIN3 in transgenic Arabidopsis decreases glucose sensitivity...
  82. ncbi New members of the tomato ERF family show specific expression pattern and diverse DNA-binding capacity to the GCC box element
    Barthélémy Tournier
    UMR 990 INRA INP ENSAT, Pole de Biotechnologie Vegetale, 24 Chemin de Borde Rouge, P O Box 107, 31326 Castanet Tolosan Cedex, France
    FEBS Lett 550:149-54. 2003
    ....
  83. pmc Ethylene-induced differential growth of petioles in Arabidopsis. Analyzing natural variation, response kinetics, and regulation
    Frank F Millenaar
    Plant Ecophysiology, Utrecht University, 3584 CA Utrecht, The Netherlands
    Plant Physiol 137:998-1008. 2005
    ..Therefore, we conclude that Ler is missing an essential component between the primary ethylene signal transduction chain and a downstream part of the hyponastic growth signal transduction pathway...
  84. pmc The eto1, eto2, and eto3 mutations and cytokinin treatment increase ethylene biosynthesis in Arabidopsis by increasing the stability of ACS protein
    Hyun Sook Chae
    Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599 3280, USA
    Plant Cell 15:545-59. 2003
    ..These results suggest that an important mechanism by which ethylene biosynthesis is controlled is the regulation of the stability of ACS, mediated at least in part through the C-terminal domain...
  85. pmc The AP2/ERF domain transcription factor ORA59 integrates jasmonic acid and ethylene signals in plant defense
    Martial Pré
    Institute of Biology Leiden, Clusius Laboratory, Leiden University, 2333 AL Leiden, The Netherlands
    Plant Physiol 147:1347-57. 2008
    ....
  86. pmc Regulation of root elongation under phosphorus stress involves changes in ethylene responsiveness
    Zhong Ma
    Department of Horticulture, The Pennsylvania State University, 103 Tyson Building, University Park, Pennsylvania 16802, USA
    Plant Physiol 131:1381-90. 2003
    ..We conclude that the root system acclimates to phosphorus deficiency by changing the signal transduction pathway connecting ethylene levels to growth and division...
  87. pmc A combinatorial interplay among the 1-aminocyclopropane-1-carboxylate isoforms regulates ethylene biosynthesis in Arabidopsis thaliana
    Atsunari Tsuchisaka
    Plant Gene Expression Center, Albany, California 94710, USA
    Genetics 183:979-1003. 2009
    ....
  88. pmc The Arabidopsis EIN3 binding F-Box proteins EBF1 and EBF2 have distinct but overlapping roles in ethylene signaling
    Brad M Binder
    Department of Botany, University of Wisconsin, Madison, Wisconsin 53706, USA
    Plant Cell 19:509-23. 2007
    ....
  89. ncbi Proteomic analysis of core breakdown disorder in Conference pears (Pyrus communis L.)
    Romina Pedreschi
    BIOSYST MeBioS Division, Katholieke Universiteit Leuven, Belgium
    Proteomics 7:2083-99. 2007
    ..Proteomics coupled to univariate and multivariate statistical techniques seems to be an efficient approach to get a better insight into the different mechanisms and pathways leading to the core breakdown disorder...
  90. pmc Ethylene-promoted elongation: an adaptation to submergence stress
    Michael B Jackson
    School of Biological Sciences, University of Bristol, Woodland Road, Bristol BS8 1UG, UK
    Ann Bot 101:229-48. 2008
    ..Many such plants elongate with increased vigour when underwater. This helps to restore contact with the aerial environment by shortening the duration of inundation. Poorly adapted species are usually incapable of this underwater escape...
  91. pmc CTR1 phosphorylates the central regulator EIN2 to control ethylene hormone signaling from the ER membrane to the nucleus in Arabidopsis
    Chuanli Ju
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    Proc Natl Acad Sci U S A 109:19486-91. 2012
    ..These findings significantly advance our understanding of the mechanisms underlying ethylene signal transduction...
  92. ncbi Bacillus megaterium rhizobacteria promote growth and alter root-system architecture through an auxin- and ethylene-independent signaling mechanism in Arabidopsis thaliana
    José López-Bucio
    Instituto de Investigaciones Quimico Biologicas, Universidad Michoacana de San Nicolás de Hidalgo Edificio B3, Ciudad Universitaria, C P 58030 Morelia, Michoacan, Mexico
    Mol Plant Microbe Interact 20:207-17. 2007
    ..Taken together, our results suggest that plant-growth promotion and root-architectural alterations by B. megaterium may involve auxin- and-ethylene independent mechanisms...
  93. ncbi Ethylene-induced differential petiole growth in Arabidopsis thaliana involves local microtubule reorientation and cell expansion
    Joanna K Polko
    Plant Ecophysiology, Institute of Environmental Biology, Utrecht University, Utrecht, The Netherlands
    New Phytol 193:339-48. 2012
    ..This work provides evidence that ethylene stimulates cell expansion in a tissue-specific manner and that it is associated with tissue-specific changes in the arrangement of CMTs along the petiole...
  94. pmc Ethylene-induced differential gene expression during abscission of citrus leaves
    Javier Agusti
    Instituto Valenciano de Investigaciones Agrarias, Centro de Genomica, Ctra de Moncada Náquera km 4 5, E 46113 Moncada, Valencia, Spain
    J Exp Bot 59:2717-33. 2008
    ....
  95. pmc Transcriptome and metabolite profiling show that APETALA2a is a major regulator of tomato fruit ripening
    Rumyana Karlova
    Laboratory of Molecular Biology, Wageningen University, 6700 AP Wageningen, The Netherlands
    Plant Cell 23:923-41. 2011
    ..Moreover, we demonstrated that CNR binds to the promoter of AP2a in vitro...
  96. pmc S-Nitrosoglutathione reductase (GSNOR) mediates the biosynthesis of jasmonic acid and ethylene induced by feeding of the insect herbivore Manduca sexta and is important for jasmonate-elicited responses in Nicotiana attenuata
    Hendrik Wünsche
    Department of Molecular Ecology, Max Planck Institute for Chemical Ecology, Hans Knoell Str 8, D 07745 Jena, Germany
    J Exp Bot 62:4605-16. 2011
    ..Our data also suggest that GSNOR could be a target of genetic modification for improving crop resistance to herbivores...
  97. ncbi Combined transcriptome, genetic diversity and metabolite profiling in tomato fruit reveals that the ethylene response factor SlERF6 plays an important role in ripening and carotenoid accumulation
    Je Min Lee
    Boyce Thompson Institute for Plant Research, Tower Rd, Cornell University Campus, Ithaca, NY 14853, USA
    Plant J 70:191-204. 2012
    ..Reduced expression of SlERF6 by RNAi enhanced both carotenoid and ethylene levels during fruit ripening, demonstrating an important role for SlERF6 in ripening, integrating the ethylene and carotenoid synthesis pathways...
  98. pmc Histidine kinase activity of the ethylene receptor ETR1 facilitates the ethylene response in Arabidopsis
    Brenda P Hall
    Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
    Plant Physiol 159:682-95. 2012
    ..Models for how enzymatic and nonenzymatic regulation may facilitate signaling from the ethylene receptors are discussed...
  99. ncbi Ethylene signaling renders the jasmonate response of Arabidopsis insensitive to future suppression by salicylic Acid
    Antonio Leon-Reyes
    Plant Microbe Interactions, Department of Biology, Faculty of Science, Utrecht University, P O Box 800 56 3508 TB Utrecht, The Netherlands
    Mol Plant Microbe Interact 23:187-97. 2010
    ....
  100. pmc Hydrogen peroxide mediates plant root cell response to nutrient deprivation
    Ryoung Shin
    Donald Danforth Plant Science Center, St Louis, MO 63132, USA
    Proc Natl Acad Sci U S A 101:8827-32. 2004
    ..ROS production is an early root response to K(+) deficiency that modulates gene expression and physiological changes in the kinetics of K(+) uptake...
  101. pmc Kiwifruit EIL and ERF genes involved in regulating fruit ripening
    Xue Ren Yin
    New Zealand Institute for Plant and Food Research, Auckland, New Zealand
    Plant Physiol 153:1280-92. 2010
    ..These results support a role for kiwifruit EILs and ERFs in transcriptional regulation of ripening-related genes and in the regulation of kiwifruit fruit-ripening processes...

Research Grants28

  1. ISOMERIC RETINOIDS, CAROTENOIDS, THEIR PROTEIN COMPLEXES
    Robert Liu; Fiscal Year: 2001
    ..g., material science). The new sets of retinoids and carotenoids will not only be useful for our own studies but also for other biochemical and pharmaceutical researches. ..
  2. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  3. SYNTHESIS OF SPONGISTATIN ANTITUMOR AGENTS
    AMOS SMITH; Fiscal Year: 2007
    ..abstract_text> ..
  4. Tandem Cycloaddition Chemistry of 2-Azoniaheterodienes
    SCOTT DENMARK; Fiscal Year: 2007
    ..abstract_text> ..
  5. Cell Fate Decision by CLV1 in Shoot Apical Meristem
    Xiang Qu; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  6. 400 MHZ NMR SPECTROMETER
    Rodney Johnson; Fiscal Year: 2008
    ..Their research addresses a number of different disease areas including Parkinson's disease, schizophrenia, pain, pulmonary fibrosis, anticancer therapy, carcinogenesis, and tuberculosis. [unreadable] [unreadable] [unreadable]..
  7. Two-Photon Fluorescence Probe Development for in Vivo Spatial and Temporal Angiog
    KEVIN BELFIELD; Fiscal Year: 2008
    ..Such a breakthrough will afford a better understanding of disease processes and the mechanism of action of drugs and other species in vivo. [unreadable] [unreadable] [unreadable]..
  8. New Methodology for Indole Alkaloid Syntheses
    Ken S Feldman; Fiscal Year: 2010
    ..The use of a new variant of the Pummerer reaction to control both oxidation level and reaction site within the indole nucleus forms the basis of this chemistry. ..
  9. Controlled Catalytic Reduction of Dinitrogen at a Transition Metal Center
    Richard R Schrock; Fiscal Year: 2010
    ..abstract_text> ..
  10. Integrating microbial biostimulation and electrolytic aeration to degrade POPs
    Harold D May; Fiscal Year: 2010
    ..Implementation of a tractable in situ detoxification process to organohalide impacted sites will mitigate exposure to the food chain and subsequent exposure risks to the general public. ..
  11. Cross-Coupling Reactions of Organosilanols
    SCOTT DENMARK; Fiscal Year: 2009
    ..Synthetic approaches to isodomoic acid H, hepatitis C viral inihibiting indole alkaloids, the salicylihalimide macrolactone oximidine II, and polyene antiviral antibiotic viridenomycin are detailed. ..
  12. Alkynyliodonium Salts and Derived Diyls in Synthesis
    Ken Feldman; Fiscal Year: 2009
    ..abstract_text> ..
  13. RTE, a plant growth gene with a conserved role in metals
    Caren Chang; Fiscal Year: 2009
    ..The elucidation of RTE function should have a direct impact on understanding the processes of metal homeostasis for the benefit of human health. ..
  14. Ruthenium Catalyzed Bond Activation Reactions
    CHAE YI; Fiscal Year: 2006
    ..The proposed research will provide new catalytic methods for the synthesis of anticancer drugs and anti-inflammatory agents. [unreadable] [unreadable] [unreadable]..
  15. Design and Synthesis of HIV-1 Protease Inhibitors
    AMOS SMITH; Fiscal Year: 2004
    ....
  16. REACTIVE INTERMEDIATES OF CARCINOGENESIS OF PAHS
    KENNETH LAALI; Fiscal Year: 2004
    ..DNA binding and mammalian cell mutagenicity studies on the substituted and derivatized-PAHs proposed for stable ion work will enhance the available literature data on structure/reactivity relationships. ..
  17. SYNTHESIS OF CHLOROPEPTINS, GP120 CD4 BINDING INHIBITORS
    AMOS SMITH; Fiscal Year: 2001
    ..abstract_text> ..
  18. LC-MS/MS Methods for Analysis of Hemoglogbin Adducts
    Timothy Fennell; Fiscal Year: 2004
    ..abstract_text> ..
  19. In Vivo High Resolution 1H slow-MAS NMR Spectroscopy
    ROBERT WIND; Fiscal Year: 2004
    ..In fact, the technique may even become useful for examining patients in the clinic, in this case by rotating the magnetic field rather than the patient. ..
  20. Microbial Degradation of Petroleum Hydrocarbons and PCBs
    HAROLD MAY; Fiscal Year: 2004
    ..It is predicted that this innovative research will lead to the development of new technologies for the co-bioremediation of PCBs and petroleum. ..
  21. Chemical and Biological Studies on Biaryl Phenolics
    Ken Feldman; Fiscal Year: 2005
    ..The search for selective 20S proteosome inhibitors among the Ntn-type proteases will be advanced by these investigations. ..
  22. Genome Wide Analysis of DNA Methylation
    Joseph Ecker; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  23. SYNTHESIS OF NOVEL BIOLOGICALLY ACTIVE NATURAL PRODUCTS
    ROBERT BOECKMAN; Fiscal Year: 2002
    ..The hypothesis that an internal chelate of suitably disposed oxygen functions permits the modification of the ring conformation from half-chair to half-boat will be tested. ..
  24. NMR systems : 2 Bruker Avance 500 Consoles
    AMOS SMITH; Fiscal Year: 2006
    ..The areas of public health research include, among others, cancer, infectious diseases, neurodegenerative diseases such as Alzheimer's disease, and heart and cardiovascular disease. [unreadable] [unreadable] [unreadable]..
  25. CHEMISTRY-BIOLOGY INTERFACE TRAINING PROGRAM
    Michael Pirrung; Fiscal Year: 2003
    ..It is intended to train future leaders in pharmaceutical, medical, and biotechnological research to serve in academia, government, and industry. ..
  26. COMBINATORIAL APPROACHES TO ANTI-SMALLPOX AGENTS
    Michael Pirrung; Fiscal Year: 2003
    ....
  27. Medicinal Chemistry and Biology of Oral Insulin Mimics
    Michael Pirrung; Fiscal Year: 2006
    ..They would therefore increase the reliability of diabetes management, particularly for children. ..
  28. BIOORGANIC CHEMISTRY OF ANTIBACTERIALS
    Michael Pirrung; Fiscal Year: 2001
    ..An ancillary benefit of this project will be the development of novel techniques in solid phase synthesis through the total synthesis of natural products. ..