ethylenes

Summary

Summary: Derivatives of ethylene, a simple organic gas of biological origin with many industrial and biological use.

Top Publications

  1. pmc ETHYLENE RESPONSE FACTOR1 integrates signals from ethylene and jasmonate pathways in plant defense
    Oscar Lorenzo
    Departamento de Genética Molecular de Plantas, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, Campus Universidad Autonoma, 28049 Madrid, Spain
    Plant Cell 15:165-78. 2003
  2. ncbi Signal signature and transcriptome changes of Arabidopsis during pathogen and insect attack
    Martin De Vos
    Graduate School Experimental Plant Sciences, Section Phytopathology, Department of Biology, Utrecht Faculty of Science, Utrecht University, P O Box 800 84, 3508 TB Utrecht, The Netherlands
    Mol Plant Microbe Interact 18:923-37. 2005
  3. ncbi Genome-wide insertional mutagenesis of Arabidopsis thaliana
    Jose M Alonso
    Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Science 301:653-7. 2003
  4. pmc Multilevel interactions between ethylene and auxin in Arabidopsis roots
    Anna N Stepanova
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Plant Cell 19:2169-85. 2007
  5. doi Recent advances in ethylene research
    Zhefeng Lin
    Division of Plant and Crop Sciences, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UK
    J Exp Bot 60:3311-36. 2009
  6. ncbi Cross talk between signaling pathways in pathogen defense
    Barbara N Kunkel
    Department of Biology, Washington University, Campus Box 1137, 1 Brookings Drive, St Louis, Missouri 63130, USA
    Curr Opin Plant Biol 5:325-31. 2002
  7. pmc Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signalling
    Sang Dong Yoo
    Department of Molecular Biology, Massachusetts General Hospital, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 451:789-95. 2008
  8. pmc Transcriptional profiling reveals novel interactions between wounding, pathogen, abiotic stress, and hormonal responses in Arabidopsis
    Yong Hwa Cheong
    Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, CA 94720, USA
    Plant Physiol 129:661-77. 2002
  9. ncbi EIN2, a bifunctional transducer of ethylene and stress responses in Arabidopsis
    J M Alonso
    Plant Science Institute, Department of Biology, University of Pennsylvania, Philadelphia, PA 19104 6018, USA
    Science 284:2148-52. 1999
  10. pmc Jasmonate signaling: toward an integrated view
    Kemal Kazan
    Commonwealth Scientific and Industrial Research Organization Plant Industry, Queensland Bioscience Precinct, St Lucia, Queensland 4067, Australia
    Plant Physiol 146:1459-68. 2008

Detail Information

Publications240 found, 100 shown here

  1. pmc ETHYLENE RESPONSE FACTOR1 integrates signals from ethylene and jasmonate pathways in plant defense
    Oscar Lorenzo
    Departamento de Genética Molecular de Plantas, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, Campus Universidad Autonoma, 28049 Madrid, Spain
    Plant Cell 15:165-78. 2003
    ....
  2. ncbi Signal signature and transcriptome changes of Arabidopsis during pathogen and insect attack
    Martin De Vos
    Graduate School Experimental Plant Sciences, Section Phytopathology, Department of Biology, Utrecht Faculty of Science, Utrecht University, P O Box 800 84, 3508 TB Utrecht, The Netherlands
    Mol Plant Microbe Interact 18:923-37. 2005
    ....
  3. ncbi Genome-wide insertional mutagenesis of Arabidopsis thaliana
    Jose M Alonso
    Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Science 301:653-7. 2003
    ..Insertion mutations were identified in genes that are regulated in response to the plant hormone ethylene...
  4. pmc Multilevel interactions between ethylene and auxin in Arabidopsis roots
    Anna N Stepanova
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Plant Cell 19:2169-85. 2007
    ..This model not only implies existence of several levels of interaction but also provides a likely explanation for the strong ethylene response defects observed in auxin mutants...
  5. doi Recent advances in ethylene research
    Zhefeng Lin
    Division of Plant and Crop Sciences, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UK
    J Exp Bot 60:3311-36. 2009
    ....
  6. ncbi Cross talk between signaling pathways in pathogen defense
    Barbara N Kunkel
    Department of Biology, Washington University, Campus Box 1137, 1 Brookings Drive, St Louis, Missouri 63130, USA
    Curr Opin Plant Biol 5:325-31. 2002
    ..The SA and JA signaling pathways are mutually antagonistic. This regulatory cross talk may have evolved to allow plants to fine-tune the induction of their defenses in response to different plant pathogens...
  7. pmc Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signalling
    Sang Dong Yoo
    Department of Molecular Biology, Massachusetts General Hospital, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 451:789-95. 2008
    ..The results suggest a new paradigm for linking intertwined MAPK cascades to control quantitative responses and specificity in signalling networks...
  8. pmc Transcriptional profiling reveals novel interactions between wounding, pathogen, abiotic stress, and hormonal responses in Arabidopsis
    Yong Hwa Cheong
    Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, CA 94720, USA
    Plant Physiol 129:661-77. 2002
    ..These results further dissected the nature of mechanical wounding as a stress signal and identified new genes that may play a role in wounding and other signal transduction pathways...
  9. ncbi EIN2, a bifunctional transducer of ethylene and stress responses in Arabidopsis
    J M Alonso
    Plant Science Institute, Department of Biology, University of Pennsylvania, Philadelphia, PA 19104 6018, USA
    Science 284:2148-52. 1999
    ..EIN2 is thus recognized as a molecular link between previously distinct hormone response pathways. Plants may use a combinatorial mechanism for assessing various stresses by enlisting a common set of signaling molecules...
  10. pmc Jasmonate signaling: toward an integrated view
    Kemal Kazan
    Commonwealth Scientific and Industrial Research Organization Plant Industry, Queensland Bioscience Precinct, St Lucia, Queensland 4067, Australia
    Plant Physiol 146:1459-68. 2008
  11. ncbi A MADS-box gene necessary for fruit ripening at the tomato ripening-inhibitor (rin) locus
    Julia Vrebalov
    U S Department of Agriculture Agricultural Research Service USDA ARS Plant, Soil and Nutrition Lab and Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, NY 14853, USA
    Science 296:343-6. 2002
    ..LeMADS-RIN demonstrates an agriculturally important function of plant MADS-box genes and provides molecular insight into nonhormonal (developmental) regulation of ripening...
  12. pmc Ethylene modulates the role of NONEXPRESSOR OF PATHOGENESIS-RELATED GENES1 in cross talk between salicylate and jasmonate signaling
    Antonio Leon-Reyes
    Plant Microbe Interactions, Department of Biology, Faculty of Science, Utrecht University, 3508 TB Utrecht, The Netherlands
    Plant Physiol 149:1797-809. 2009
    ..Our results suggest a model in which ET modulates the NPR1 dependency of SA-JA antagonism, possibly to compensate for enhanced allocation of NPR1 to function in SA-dependent activation of PR genes...
  13. ncbi AtNAC2, a transcription factor downstream of ethylene and auxin signaling pathways, is involved in salt stress response and lateral root development
    Xin Jian He
    National Key Lab of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Plant J 44:903-16. 2005
    ..AtNAC2 also promoted or inhibited downstream gene expressions. These results indicate that AtNAC2 may be a transcription factor incorporating the environmental and endogenous stimuli into the process of plant lateral root development...
  14. ncbi Integration of plant responses to environmentally activated phytohormonal signals
    Patrick Achard
    John Innes Centre, Norwich NR4 7UJ, UK
    Science 311:91-4. 2006
    ..The growth restraint conferred by DELLA proteins is beneficial and promotes survival. We propose that DELLAs permit flexible and appropriate modulation of plant growth in response to changes in natural environments...
  15. pmc ARABIDOPSIS DEHISCENCE ZONE POLYGALACTURONASE1 (ADPG1), ADPG2, and QUARTET2 are Polygalacturonases required for cell separation during reproductive development in Arabidopsis
    Mikihiro Ogawa
    CSIRO Plant Industry, Private Mail Bag, Merbein, Victoria 3505, Australia
    Plant Cell 21:216-33. 2009
    ..These results demonstrate that multiple cell separation events, including both abscission and dehiscence, require closely related PG genes...
  16. pmc Ethylene signaling: new levels of complexity and regulation
    Mandy D Kendrick
    Department of Cell Biology and Molecular Genetics, Bioscience Research Building, University of Maryland, College Park, MD 20742, USA
    Curr Opin Plant Biol 11:479-85. 2008
    ..Additionally, EIN3 possesses two mitogen-activated protein kinase (MAPK) phosphorylation sites that have opposing effects on EIN3 stability...
  17. doi Ripening of fleshy fruit: molecular insight and the role of ethylene
    Vishwas A Bapat
    Department of Biotechnology, Shivaji University, Kolhapur 416 004, India
    Biotechnol Adv 28:94-107. 2010
    ..Role of ethylene and ethylene-responsive genes in ripening of fleshy fruit is also included. Taking clues from the studies in tomato as a model fruit, few case studies are reviewed...
  18. doi Molecular aspects of seed dormancy
    Ruth Finkelstein
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, California 93106 9610, USA
    Annu Rev Plant Biol 59:387-415. 2008
    ..The net result is a slightly heterogeneous response, thereby providing more temporal options for successful germination...
  19. pmc Phosphorylation of 1-aminocyclopropane-1-carboxylic acid synthase by MPK6, a stress-responsive mitogen-activated protein kinase, induces ethylene biosynthesis in Arabidopsis
    Yidong Liu
    Department of Biochemistry, University of Missouri, Columbia, Missouri 65211, USA
    Plant Cell 16:3386-99. 2004
    ..Equally important, this study uncovers a signaling pathway that modulates the biosynthesis of ethylene, an important plant hormone, in plants under stress...
  20. ncbi Ethylene: a gaseous signal molecule in plants
    A B Bleecker
    Departments of Botany and Genetics, University of Wisconsin, Madison, Wisconsin 53706 1381, USA
    Annu Rev Cell Dev Biol 16:1-18. 2000
    ..Biotechnological modifications of ethylene synthesis and of sensitivity to ethylene are promising methods to prevent spoilage of agricultural products such as fruits, whose ripening is induced by ethylene...
  21. pmc The role of ethylene and cold temperature in the regulation of the apple POLYGALACTURONASE1 gene and fruit softening
    Emma Tacken
    New Zealand Institute of Plant and Food Research, Auckland 1142, New Zealand
    Plant Physiol 153:294-305. 2010
    ....
  22. doi Ethylene signalling and ethylene-targeted transcription factors are required to balance beneficial and nonbeneficial traits in the symbiosis between the endophytic fungus Piriformospora indica and Arabidopsis thaliana
    Iris Camehl
    Friedrich Schiller Universitat Jena, Institut für Allgemeine Botanik und Pflanzenphysiologie, Jena, Germany
    New Phytol 185:1062-73. 2010
    ..The results show that the restriction of fungal growth by ethylene signalling components is required for the beneficial interaction between the two symbionts...
  23. doi Ethylene signaling and response: where different regulatory modules meet
    Anna N Stepanova
    Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA
    Curr Opin Plant Biol 12:548-55. 2009
    ..Tissue-specific regulation of auxin biosynthesis, transport, and response by ethylene is emerging as a key element in this signal integration process...
  24. ncbi Plant responses to ethylene gas are mediated by SCF(EBF1/EBF2)-dependent proteolysis of EIN3 transcription factor
    Hongwei Guo
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cell 115:667-77. 2003
    ..These results reveal that a ubiquitin/proteasome pathway negatively regulates ethylene responses by targeting EIN3 for degradation, and pinpoint EIN3 regulation as the key step in the response to ethylene...
  25. ncbi Cytokinin and auxin inhibit abscisic acid-induced stomatal closure by enhancing ethylene production in Arabidopsis
    Yoko Tanaka
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwanoha, Kashiwa, Chiba 277 8562, Japan
    J Exp Bot 57:2259-66. 2006
    ..The above observations suggest that cytokinins and auxins inhibit ABA-induced stomatal closure through the modulation of ethylene biosynthesis, and that ethylene inhibits the ABA-induced reduction of osmotic pressure in the guard cells...
  26. ncbi A conditionally fertile coi1 allele indicates cross-talk between plant hormone signalling pathways in Arabidopsis thaliana seeds and young seedlings
    Christine Ellis
    School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK
    Planta 215:549-56. 2002
    ..We have used coi1-16 seeds to define novel interactions between JA and other hormone signalling pathways in seed germination and in the development of young seedlings...
  27. doi Hormone interactions in stomatal function
    Biswa R Acharya
    Biology Department, Pennsylvania State University, 208 Mueller Laboratory, University Park, PA 16802, USA
    Plant Mol Biol 69:451-62. 2009
    ..Here, we discuss the roles of different phytohormones and the effects of their interactions on guard cell physiology and function...
  28. ncbi MAPMAN: a user-driven tool to display genomics data sets onto diagrams of metabolic pathways and other biological processes
    Oliver Thimm
    Max Planck Institute for Molecular Plant Physiology, Golm, Germany
    Plant J 37:914-39. 2004
    ....
  29. pmc The regulation of MADS-box gene expression during ripening of banana and their regulatory interaction with ethylene
    Tomer Elitzur
    Department of Postharvest Science of Fresh Produce, Agricultural Research Organization ARO, The Volcani Center, PO Box 6, Bet Dagan 50250, Israel
    J Exp Bot 61:1523-35. 2010
    ..Hence, our results are consistent with MaMADS2, a SEP3 homologue, acting in the pulp upstream of the increase in ethylene production similarly to LeMADS-RIN...
  30. ncbi The involvement of auxin in the ripening of climacteric fruits comes of age: the hormone plays a role of its own and has an intense interplay with ethylene in ripening peaches
    Livio Trainotti
    Dipartimento di Biologia, Universita di Padova, Via G Colombo 3, I 35131 Padova, Italy
    J Exp Bot 58:3299-308. 2007
    ..This study has also demonstrated the existence of an important cross-talk between auxin and ethylene, with genes in the auxin domain regulated by ethylene and genes in the ethylene domain regulated by auxin...
  31. ncbi Different plant hormones regulate similar processes through largely nonoverlapping transcriptional responses
    Jennifer L Nemhauser
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cell 126:467-75. 2006
    ..Instead, different hormones appear to regulate distinct members of protein families. We conclude that there is not a core transcriptional growth-regulatory module in young Arabidopsis seedlings...
  32. pmc EIR1, a root-specific protein involved in auxin transport, is required for gravitropism in Arabidopsis thaliana
    C Luschnig
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142 1479 USA
    Genes Dev 12:2175-87. 1998
    ..Expression of the EIR1 gene in Saccharomyces cerevisiae confers resistance to fluorinated indolic compounds. Taken together, these data suggest that the EIR1 protein has a root-specific role in the transport of auxin...
  33. pmc Ethylene biosynthesis and signaling networks
    Kevin L C Wang
    Plant Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Plant Cell 14:S131-51. 2002
  34. pmc Co-ordination of early and late ripening events in apples is regulated through differential sensitivities to ethylene
    Jason W Johnston
    The New Zealand Institute for Plant and Food Research Limited, Private Bag 92169, Auckland, New Zealand
    J Exp Bot 60:2689-99. 2009
    ..These results suggest a conceptual model for the control of individual ripening characters in apple, based on both ethylene dependency and sensitivity...
  35. pmc The role of ethylene and wound signaling in resistance of tomato to Botrytis cinerea
    Jose Diaz
    Wageningen University Plant Sciences, Laboratory of Phytopathology, Binnenhaven 5, P O Box 8025, 6700 EE, Wageningen, The Netherlands
    Plant Physiol 129:1341-51. 2002
    ..Ethylene and wound signaling acted independently on resistance. Salicylate and ethylene acted synergistically on defense gene expression, but antagonistically on resistance...
  36. pmc A MAPK pathway mediates ethylene signaling in plants
    Fatma Ouaked
    Gregor Mendel Institute of Molecular Plant Sciences and Institute of Microbiology and Genetics, Vienna Biocenter, University of Vienna, Dr Bohrgasse 9, A 1030 Vienna, Austria
    EMBO J 22:1282-8. 2003
    ..In contrast, ctr1 mutants showed constitutive activation of MPK6. These data indicate that a MAPK cascade is part of the ethylene signal transduction pathway in plants...
  37. doi Identification, phylogeny, and transcript profiling of ERF family genes during development and abiotic stress treatments in tomato
    Manoj K Sharma
    Department of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110021, India
    Mol Genet Genomics 284:455-75. 2010
    ..Results suggest that ERF genes play diverse roles in plant's life and comprehensive data generated will be helpful in conducting functional genomics studies to understand their precise role during plant development and stress response...
  38. pmc The response regulator 2 mediates ethylene signalling and hormone signal integration in Arabidopsis
    Claudia Hass
    Botanisches Institut, Universitat zu Koln, Koln, Germany
    EMBO J 23:3290-302. 2004
    ....
  39. pmc Genetic regulation of fruit development and ripening
    James J Giovannoni
    United States Department of Agriculture Agricultural Research Service Plant, Soil, and Nutrition Laboratory and Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, New York 14853, USA
    Plant Cell 16:S170-80. 2004
  40. pmc The Arabidopsis mutant cev1 has constitutively active jasmonate and ethylene signal pathways and enhanced resistance to pathogens
    C Ellis
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, United Kingdom
    Plant Cell 13:1025-33. 2001
    ..We conclude that cev1 stimulates both the JA and the ethylene signal pathways and that CEV1 regulates an early step in an Arabidopsis defense pathway...
  41. doi TAA1-mediated auxin biosynthesis is essential for hormone crosstalk and plant development
    Anna N Stepanova
    Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA
    Cell 133:177-91. 2008
    ..Thus, the IPA route of auxin production is key to generating robust auxin gradients in response to environmental and developmental cues...
  42. pmc Ethylene-induced differential growth of petioles in Arabidopsis. Analyzing natural variation, response kinetics, and regulation
    Frank F Millenaar
    Plant Ecophysiology, Utrecht University, 3584 CA Utrecht, The Netherlands
    Plant Physiol 137:998-1008. 2005
    ..Therefore, we conclude that Ler is missing an essential component between the primary ethylene signal transduction chain and a downstream part of the hyponastic growth signal transduction pathway...
  43. pmc Phosphate availability alters architecture and causes changes in hormone sensitivity in the Arabidopsis root system
    José López-Bucio
    Departamento de Ingeniería Genética de Plantas, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Unidad Irapuato, Apartado Postal 629, 36500 Irapuato, Guanajuato, Mexico
    Plant Physiol 129:244-56. 2002
    ..These results suggest that in Arabidopsis, auxin sensitivity may play a fundamental role in the modifications of root architecture by P availability...
  44. ncbi New members of the tomato ERF family show specific expression pattern and diverse DNA-binding capacity to the GCC box element
    Barthélémy Tournier
    UMR 990 INRA INP ENSAT, Pole de Biotechnologie Vegetale, 24 Chemin de Borde Rouge, P O Box 107, 31326 Castanet Tolosan Cedex, France
    FEBS Lett 550:149-54. 2003
    ....
  45. ncbi Differential regulation of EIN3 stability by glucose and ethylene signalling in plants
    Shuichi Yanagisawa
    Research Institute for Bioresources, Okayama University, Chuo 2 20 1, Kurashiki 710 0046, Japan
    Nature 425:521-5. 2003
    ..Ethylene, by contrast, enhances the stability of EIN3. The ein3 mutant has a glo phenotype, and overexpression of EIN3 in transgenic Arabidopsis decreases glucose sensitivity...
  46. pmc The eto1, eto2, and eto3 mutations and cytokinin treatment increase ethylene biosynthesis in Arabidopsis by increasing the stability of ACS protein
    Hyun Sook Chae
    Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599 3280, USA
    Plant Cell 15:545-59. 2003
    ..These results suggest that an important mechanism by which ethylene biosynthesis is controlled is the regulation of the stability of ACS, mediated at least in part through the C-terminal domain...
  47. pmc The WRKY70 transcription factor: a node of convergence for jasmonate-mediated and salicylate-mediated signals in plant defense
    Jing Li
    Department of Biosciences, Division of Genetics, University of Helsinki, FIN 00014 Helsinki, Finland
    Plant Cell 16:319-31. 2004
    ..We suggest that WRKY70 acts as an activator of SA-induced genes and a repressor of JA-responsive genes, integrating signals from these mutually antagonistic pathways...
  48. pmc The AP2/ERF domain transcription factor ORA59 integrates jasmonic acid and ethylene signals in plant defense
    Martial Pré
    Institute of Biology Leiden, Clusius Laboratory, Leiden University, 2333 AL Leiden, The Netherlands
    Plant Physiol 147:1347-57. 2008
    ....
  49. doi A tomato (Solanum lycopersicum) APETALA2/ERF gene, SlAP2a, is a negative regulator of fruit ripening
    Mi Young Chung
    Boyce Thompson Institute for Plant Research, Tower Road, Cornell University Campus, Ithaca, NY 14853, USA
    Plant J 64:936-47. 2010
    ..These results suggest that SlAP2a functions during normal tomato fruit ripening as a modulator of ripening activity and acts to balance the activities of positive ripening regulators...
  50. pmc Regulation of root elongation under phosphorus stress involves changes in ethylene responsiveness
    Zhong Ma
    Department of Horticulture, The Pennsylvania State University, 103 Tyson Building, University Park, Pennsylvania 16802, USA
    Plant Physiol 131:1381-90. 2003
    ..We conclude that the root system acclimates to phosphorus deficiency by changing the signal transduction pathway connecting ethylene levels to growth and division...
  51. pmc The mitogen-activated protein kinase cascade MKK3-MPK6 is an important part of the jasmonate signal transduction pathway in Arabidopsis
    Fuminori Takahashi
    Gene Discovery Research Group, RIKEN Plant Science Center, Tsukuba, Ibaraki 305 0074, Japan
    Plant Cell 19:805-18. 2007
    ..We provide a model explaining how MPK6 can convert three distinct signals - JA, pathogen, and cold/salt stress - into three different sets of responses in Arabidopsis...
  52. doi HRE1 and HRE2, two hypoxia-inducible ethylene response factors, affect anaerobic responses in Arabidopsis thaliana
    Francesco Licausi
    Plant Lab, Scuola Superiore Sant Anna, Piazza Martiri della Libertà 33, 56127 Pisa, Italy
    Plant J 62:302-15. 2010
    ..We propose that HRE1 and HRE2 play a partially redundant role in low oxygen signalling in Arabidopsis thaliana, thus improving the tolerance of the plant to the stress by enhancing anaerobic gene expression and ethanolic fermentation...
  53. pmc A combinatorial interplay among the 1-aminocyclopropane-1-carboxylate isoforms regulates ethylene biosynthesis in Arabidopsis thaliana
    Atsunari Tsuchisaka
    Plant Gene Expression Center, Albany, California 94710, USA
    Genetics 183:979-1003. 2009
    ....
  54. pmc The Arabidopsis EIN3 binding F-Box proteins EBF1 and EBF2 have distinct but overlapping roles in ethylene signaling
    Brad M Binder
    Department of Botany, University of Wisconsin, Madison, Wisconsin 53706, USA
    Plant Cell 19:509-23. 2007
    ....
  55. pmc CTR1 phosphorylates the central regulator EIN2 to control ethylene hormone signaling from the ER membrane to the nucleus in Arabidopsis
    Chuanli Ju
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    Proc Natl Acad Sci U S A 109:19486-91. 2012
    ..These findings significantly advance our understanding of the mechanisms underlying ethylene signal transduction...
  56. ncbi Proteomic analysis of core breakdown disorder in Conference pears (Pyrus communis L.)
    Romina Pedreschi
    BIOSYST MeBioS Division, Katholieke Universiteit Leuven, Belgium
    Proteomics 7:2083-99. 2007
    ..Proteomics coupled to univariate and multivariate statistical techniques seems to be an efficient approach to get a better insight into the different mechanisms and pathways leading to the core breakdown disorder...
  57. pmc Ethylene-promoted elongation: an adaptation to submergence stress
    Michael B Jackson
    School of Biological Sciences, University of Bristol, Woodland Road, Bristol BS8 1UG, UK
    Ann Bot 101:229-48. 2008
    ..Many such plants elongate with increased vigour when underwater. This helps to restore contact with the aerial environment by shortening the duration of inundation. Poorly adapted species are usually incapable of this underwater escape...
  58. doi Ethylene-induced differential petiole growth in Arabidopsis thaliana involves local microtubule reorientation and cell expansion
    Joanna K Polko
    Plant Ecophysiology, Institute of Environmental Biology, Utrecht University, Utrecht, The Netherlands
    New Phytol 193:339-48. 2012
    ..This work provides evidence that ethylene stimulates cell expansion in a tissue-specific manner and that it is associated with tissue-specific changes in the arrangement of CMTs along the petiole...
  59. doi Ethylene signaling renders the jasmonate response of Arabidopsis insensitive to future suppression by salicylic Acid
    Antonio Leon-Reyes
    Plant Microbe Interactions, Department of Biology, Faculty of Science, Utrecht University, P O Box 800 56 3508 TB Utrecht, The Netherlands
    Mol Plant Microbe Interact 23:187-97. 2010
    ....
  60. pmc Hydrogen peroxide mediates plant root cell response to nutrient deprivation
    Ryoung Shin
    Donald Danforth Plant Science Center, St Louis, MO 63132, USA
    Proc Natl Acad Sci U S A 101:8827-32. 2004
    ..ROS production is an early root response to K(+) deficiency that modulates gene expression and physiological changes in the kinetics of K(+) uptake...
  61. pmc The role of ABA in triggering ethylene biosynthesis and ripening of tomato fruit
    Mei Zhang
    College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, PR China
    J Exp Bot 60:1579-88. 2009
    ....
  62. pmc Transcriptome and metabolite profiling show that APETALA2a is a major regulator of tomato fruit ripening
    Rumyana Karlova
    Laboratory of Molecular Biology, Wageningen University, 6700 AP Wageningen, The Netherlands
    Plant Cell 23:923-41. 2011
    ..Moreover, we demonstrated that CNR binds to the promoter of AP2a in vitro...
  63. pmc S-Nitrosoglutathione reductase (GSNOR) mediates the biosynthesis of jasmonic acid and ethylene induced by feeding of the insect herbivore Manduca sexta and is important for jasmonate-elicited responses in Nicotiana attenuata
    Hendrik Wünsche
    Department of Molecular Ecology, Max Planck Institute for Chemical Ecology, Hans Knoell Str 8, D 07745 Jena, Germany
    J Exp Bot 62:4605-16. 2011
    ..Our data also suggest that GSNOR could be a target of genetic modification for improving crop resistance to herbivores...
  64. pmc Ethylene-induced differential gene expression during abscission of citrus leaves
    Javier Agusti
    Instituto Valenciano de Investigaciones Agrarias, Centro de Genomica, Ctra de Moncada Náquera km 4 5, E 46113 Moncada, Valencia, Spain
    J Exp Bot 59:2717-33. 2008
    ....
  65. doi Combined transcriptome, genetic diversity and metabolite profiling in tomato fruit reveals that the ethylene response factor SlERF6 plays an important role in ripening and carotenoid accumulation
    Je Min Lee
    Boyce Thompson Institute for Plant Research, Tower Rd, Cornell University Campus, Ithaca, NY 14853, USA
    Plant J 70:191-204. 2012
    ..Reduced expression of SlERF6 by RNAi enhanced both carotenoid and ethylene levels during fruit ripening, demonstrating an important role for SlERF6 in ripening, integrating the ethylene and carotenoid synthesis pathways...
  66. ncbi Bacillus megaterium rhizobacteria promote growth and alter root-system architecture through an auxin- and ethylene-independent signaling mechanism in Arabidopsis thaliana
    José López-Bucio
    Instituto de Investigaciones Quimico Biologicas, Universidad Michoacana de San Nicolás de Hidalgo Edificio B3, Ciudad Universitaria, C P 58030 Morelia, Michoacan, Mexico
    Mol Plant Microbe Interact 20:207-17. 2007
    ..Taken together, our results suggest that plant-growth promotion and root-architectural alterations by B. megaterium may involve auxin- and-ethylene independent mechanisms...
  67. pmc Histidine kinase activity of the ethylene receptor ETR1 facilitates the ethylene response in Arabidopsis
    Brenda P Hall
    Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
    Plant Physiol 159:682-95. 2012
    ..Models for how enzymatic and nonenzymatic regulation may facilitate signaling from the ethylene receptors are discussed...
  68. pmc Kiwifruit EIL and ERF genes involved in regulating fruit ripening
    Xue Ren Yin
    New Zealand Institute for Plant and Food Research, Auckland, New Zealand
    Plant Physiol 153:1280-92. 2010
    ..These results support a role for kiwifruit EILs and ERFs in transcriptional regulation of ripening-related genes and in the regulation of kiwifruit fruit-ripening processes...
  69. doi Fusarium graminearum exploits ethylene signalling to colonize dicotyledonous and monocotyledonous plants
    X Chen
    John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK
    New Phytol 182:975-83. 2009
    ..This demonstration of translation from model to crop species provides a foundation for improving resistance of cereal crops to FHB through identification of allelic variation for components of the ethylene-signalling pathway...
  70. ncbi Auxin herbicides induce H(2)O(2) overproduction and tissue damage in cleavers (Galium aparine L.)
    K Grossmann
    BASF Agricultural Center Limburgerhof, D 67114 Limburgerhof, Germany
    J Exp Bot 52:1811-6. 2001
    ..This overproduction of H(2)O(2) could be triggered by the decline of photosynthetic activity, due to ABA-mediated stomatal closure...
  71. ncbi Enhanced ethylene responsiveness in the Arabidopsis eer1 mutant results from a loss-of-function mutation in the protein phosphatase 2A A regulatory subunit, RCN1
    Paul Brian Larsen
    Department of Biochemistry, University of California Riverside, Riverside, California, CA 92521, USA
    Plant J 34:709-18. 2003
    ....
  72. doi Genetic dissection of the role of ethylene in regulating auxin-dependent lateral and adventitious root formation in tomato
    Sangeeta Negi
    Department of Biology, Wake Forest University, Room 226 Winston Hall, Box 7325, Winston Salem, NC 27109, USA
    Plant J 61:3-15. 2010
    ..These results indicate a negative role for ethylene in lateral root formation and a positive role in adventitious root formation with modulation of auxin transport as a central point of ethylene-auxin crosstalk...
  73. ncbi Tuning the herbivore-induced ethylene burst: the role of transcript accumulation and ethylene perception in Nicotiana attenuata
    Caroline C von Dahl
    Department of Molecular Ecology, Max Planck Institute for Chemical Ecology, Beutenberg Campus, Hans Knoll Strasse 8, Jena, Germany
    Plant J 51:293-307. 2007
    ..Ethylene signaling is shown to be essential in regulating two traits that are important in the N. attenuata-M. sexta interaction: OS-induced nicotine levels and floral longevity...
  74. pmc Emerging connections in the ethylene signaling network
    Sang Dong Yoo
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Trends Plant Sci 14:270-9. 2009
    ....
  75. doi Cloning and functional analysis of 9-cis-epoxycarotenoid dioxygenase (NCED) genes encoding a key enzyme during abscisic acid biosynthesis from peach and grape fruits
    Mei Zhang
    College of Agronomy and Biotechnology, China Agricultural University, Beijing 100094, China
    J Plant Physiol 166:1241-52. 2009
    ....
  76. ncbi Transcriptional regulation of ethylene receptor and CTR genes involved in ethylene-induced flower opening in cut rose (Rosa hybrida) cv. Samantha
    Nan Ma
    Department of Ornamental Horticulture, China Agricultural University, Beijing 100094, China
    J Exp Bot 57:2763-73. 2006
    ..Samantha, and that continued ethylene perception results in flower opening. Ethylene may regulate flower opening mainly through expression of two ethylene receptor genes (Rh-ETR1 and Rh-ETR3) and two CTR (Rh-CTR1 and Rh-CTR2) genes...
  77. pmc Regulation of Arabidopsis defense responses against Spodoptera littoralis by CPK-mediated calcium signaling
    Chidananda Nagamangala Kanchiswamy
    Global COE Program Evolution and Biodiversity, Graduate School of Science, Kyoto University, Kyoto, Japan
    BMC Plant Biol 10:97. 2010
    ..Ca2+-binding sensory proteins such as Ca2+-dependent protein kinases (CPKs) have been predicted to mediate the signaling following Ca2+ influx after insect herbivory. However, until now this prediction was not testable...
  78. pmc The basic helix-loop-helix transcription factor PIF5 acts on ethylene biosynthesis and phytochrome signaling by distinct mechanisms
    Rajnish Khanna
    Department of Plant and Microbial Biology, University of California, Berkeley, California 94720, USA
    Plant Cell 19:3915-29. 2007
    ....
  79. ncbi Ethylene biosynthesis and signaling: an overview
    Annelies De Paepe
    Unit Plant Hormone Signaling and Bio Imaging, Department of Molecular Genetics Ghent University, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    Vitam Horm 72:399-430. 2005
    ....
  80. pmc Molecular and genetic characterization of a non-climacteric phenotype in melon reveals two loci conferring altered ethylene response in fruit
    Christophe Perin
    Institut National de la Recherche Agronomique, Station de Génétique et d Amélioration des Fruits et Légumes, Domaine St Maurice, Boîte Postale 94, 84143 Montfavet cedex, France
    Plant Physiol 129:300-9. 2002
    ..Five candidate genes (two ACO, two ACS, and ERS) that were localized on the melon genetic map did not exhibit colocalization with Al-3 or Al-4...
  81. pmc Transcriptional activation of a 37 kDa ethylene responsive cysteine protease gene, RbCP1, is associated with protein degradation during petal abscission in rose
    Siddharth Kaushal Tripathi
    Plant Gene Expression Laboratory, National Botanical Research Institute, Lucknow 226001, India
    J Exp Bot 60:2035-44. 2009
    ..It is concluded that petal abscission is associated with a decrease in total protein content resulting from rapid transcription of RbCP1 and the expression of a 37 kDa protease...
  82. pmc Ethylene mediates response and tolerance to potassium deprivation in Arabidopsis
    Ji Yul Jung
    Donald Danforth Plant Science Center, St Louis, Missouri 63132, USA
    Plant Cell 21:607-21. 2009
    ..Ethylene signaling is a component of the plant's response to low potassium that stimulates the production of reactive oxygen species and is important for changes in root morphology and whole plant tolerance to low potassium conditions...
  83. pmc Genetic variation for lettuce seed thermoinhibition is associated with temperature-sensitive expression of abscisic Acid, gibberellin, and ethylene biosynthesis, metabolism, and response genes
    Jason Argyris
    Department of Plant Sciences, University of California, Davis, CA 95616 8780, USA
    Plant Physiol 148:926-47. 2008
    ..The temperature sensitivity of expression of LsNCED4 may determine the upper temperature limit for lettuce seed germination and may indirectly influence other regulatory pathways via interconnected effects of increased ABA biosynthesis...
  84. pmc Antagonism between abscisic acid and ethylene in Arabidopsis acts in parallel with the reciprocal regulation of their metabolism and signaling pathways
    Wan Hsing Cheng
    Institute of Plant and Microbial Biology, Academia Sinica, Taipei, Taiwan, Republic of China
    Plant Mol Biol 71:61-80. 2009
    ..These data further suggest that ABA and ethylene may control the hormonal biosynthesis, catabolism, or signaling of each other to enhance their antagonistic effects upon seed germination and early seedling growth...
  85. doi Role of PIN-mediated auxin efflux in apical hook development of Arabidopsis thaliana
    Petra Zádníková
    Department of Plant Systems Biology, Flanders Institute for Biotechnology VIB and Department of Plant Biotechnology and Genetics, Ghent University, Gent, Belgium
    Development 137:607-17. 2010
    ..This ethylene effect is in part mediated by regulation of PIN-dependent auxin efflux and auxin signaling...
  86. pmc Ethylene-induced stabilization of ETHYLENE INSENSITIVE3 and EIN3-LIKE1 is mediated by proteasomal degradation of EIN3 binding F-box 1 and 2 that requires EIN2 in Arabidopsis
    Fengying An
    National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing 100871, China
    Plant Cell 22:2384-401. 2010
    ..Our results also reveal that EBF1 and EBF2 act as essential ethylene signal transducers that by themselves are subject to proteasomal degradation...
  87. doi Mitogen-activated protein kinase 3 and 6 regulate Botrytis cinerea-induced ethylene production in Arabidopsis
    Ling Han
    Division of Biochemistry, Interdisciplinary Plant Group and Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA
    Plant J 64:114-27. 2010
    ..cinerea-induced ethylene production. The residual levels of ethylene induction in the acs2/acs6 double mutant suggest the involvement of additional ACS isoforms, possibly regulated by MAPK-independent pathway(s)...
  88. pmc A Pseudomonas syringae type III effector suppresses cell wall-based extracellular defense in susceptible Arabidopsis plants
    Paula Hauck
    Department of Energy Plant Research Laboratory and Department of Plant Biology, Michigan State University, East Lansing, MI 48824, USA
    Proc Natl Acad Sci U S A 100:8577-82. 2003
    ..AvrPto is therefore one of the long postulated suppressors of an salicylic acid-independent, cell wall-based defense that is aimed at hrp mutant bacteria...
  89. pmc Expression of a divergent expansin gene is fruit-specific and ripening-regulated
    J K Rose
    Mann Laboratory, Department of Vegetable Crops, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 94:5955-60. 1997
    ....
  90. pmc The Arabidopsis eer1 mutant has enhanced ethylene responses in the hypocotyl and stem
    P B Larsen
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA
    Plant Physiol 125:1061-73. 2001
    ..Our findings suggest that the wild-type EER1 product acts to oppose ethylene responses in the hypocotyl and stem...
  91. pmc Activation of a stress-responsive mitogen-activated protein kinase cascade induces the biosynthesis of ethylene in plants
    Cha Young Kim
    Department of Biochemistry, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Plant Cell 15:2707-18. 2003
    ..These results suggest that the induction of ethylene but not JA/MJ is involved in plant defense responses mediated by the NtMEK2-SIPK/WIPK pathway...
  92. pmc Dominance induction of fruitlet shedding in Malus x domestica (L. Borkh): molecular changes associated with polar auxin transport
    Valeriano Dal Cin
    Department of Environmental Agronomy and Crop Science, University of Padova, Viale dell Universita 16, 35020 Legnaro Padova, Italy
    BMC Plant Biol 9:139. 2009
    ..The response to these hormones is controlled by transcription regulators such as Aux/IAA and ARR, whereas auxin transport is controlled by influx and efflux carriers...
  93. ncbi Ethylene and phosphorus availability have interacting yet distinct effects on root hair development
    Yuan Ji Zhang
    Department of Horticulture, Penn State University, University Park, PA 16802, USA
    J Exp Bot 54:2351-61. 2003
    ....
  94. ncbi Involvement of the octadecanoid pathway in bluegreen aphid resistance in Medicago truncatula
    Ling Ling Gao
    CSIRO Plant Industry, Private Bag 5, Wembley, WA 6913, Australia
    Mol Plant Microbe Interact 20:82-93. 2007
    ..Together, these results strongly suggest that the octadecanoid pathway is important for this naturally derived aphid resistance trait...
  95. pmc Ethylene and auxin control the Arabidopsis response to decreased light intensity
    Filip Vandenbussche
    Department of Molecular Genetics, University of Ghent, Belgium
    Plant Physiol 133:517-27. 2003
    ..Taken together, the data show that ethylene and auxin signaling are required for the response to low light intensities...
  96. pmc Ethylene upregulates auxin biosynthesis in Arabidopsis seedlings to enhance inhibition of root cell elongation
    Ranjan Swarup
    School of Biosciences and Centre for Plant Integrative Biology, University of Nottingham, LE12 5RD Nottingham, United Kingdom
    Plant Cell 19:2186-96. 2007
    ..We conclude that by upregulating auxin biosynthesis, ethylene facilitates its ability to inhibit root cell expansion...
  97. pmc Plastidial fatty acid signaling modulates salicylic acid- and jasmonic acid-mediated defense pathways in the Arabidopsis ssi2 mutant
    Aardra Kachroo
    Department of Plant Pathology, University of Kentucky, Lexington, Kentucky 40546, USA
    Plant Cell 15:2952-65. 2003
    ....
  98. pmc Mechanisms of cross talk between gibberellin and other hormones
    David Weiss
    Robert H Smith Institute of Plant Sciences and Genetics in Agriculture, Faculty of Agricultural, Food and Environmental Quality Sciences, Hebrew University of Jerusalem, Rehovot, Israel
    Plant Physiol 144:1240-6. 2007
  99. ncbi Auxin is a positive regulator for ethylene-mediated response in the growth of Arabidopsis roots
    A Rahman
    Graduate School of Science and Technology, Kobe University, Nada-ku, Kobe, 657-8501 Japan
    Plant Cell Physiol 42:301-7. 2001
    ..These results suggest that auxin is a positive regulator for ethylene-induced inhibition in root elongation...
  100. ncbi Arabidopsis MAP kinase 4 regulates salicylic acid- and jasmonic acid/ethylene-dependent responses via EDS1 and PAD4
    Peter Brodersen
    Institute of Molecular Biology, Copenhagen University, Øster Farimagsgade 2A, DK 1353 Copenhagen K, Denmark
    Plant J 47:532-46. 2006
    ..The regulation of some, but not all, of these genes involves EDS1 and PAD4...
  101. ncbi Host and non-host pathogens elicit different jasmonate/ethylene responses in Arabidopsis
    Laurent Zimmerli
    Department of Plant Biology, Carnegie Institution of Washington, Stanford, CA 94305, USA
    Plant J 40:633-46. 2004
    ..Taken together, these data suggest that biotrophic host pathogens must either suppress or fail to elicit the JA/ET signal transduction pathway...

Research Grants76

  1. ISOMERIC RETINOIDS, CAROTENOIDS, THEIR PROTEIN COMPLEXES
    Robert Liu; Fiscal Year: 2001
    ..g., material science). The new sets of retinoids and carotenoids will not only be useful for our own studies but also for other biochemical and pharmaceutical researches. ..
  2. SYNTHESIS OF MACROCYCLES STEROIDS CYCLOPENTANOIDS ETC
    BARRY TROST; Fiscal Year: 2001
    ..Ring expansion methods may convert these cores into the taxoid skeleton with appropriate functionality at key points for analog development. ..
  3. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  4. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2007
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  5. Novel Approaches for Antitumor and Antiviral Agents
    Barry M Trost; Fiscal Year: 2010
    ..This proposal helps to address this key challenge by developing the underlying initial technology within classes of compounds having demonstrably antitumor or antiviral activities. ..
  6. NOVEL APPROACHES TO ANTITUMOR AND ANTIVIRAL AGENTS
    BARRY TROST; Fiscal Year: 2007
    ..By expediting access to very diverse arrays of structural types, the best opportunities to discover new therapeutic agents arise. ..
  7. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2007
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  8. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2006
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  9. Synthesis of Macrolides. Steroids, Cyclopentanoids, etc
    BARRY TROST; Fiscal Year: 2005
    ..This new concept sets the stage for solutions to a long standing problem, the ion channel blockers, the grayanotoxins. as well as the more recently discovered rameswaralide, a potent antiinflamatory. ..
  10. NOVEL APPROACHES TO ANTITUMOR AND ANTIVIRAL AGENTS
    BARRY TROST; Fiscal Year: 2004
    ..By accessing a very diverse range of structural types, the best opportunities to discover new therapeutic agents arise. ..
  11. NOVEL APPROACHES TO ANTITUMOR AND ANTIVIRAL AGENTS
    BARRY TROST; Fiscal Year: 2000
    ..Equally important, new avenues to vary structure around these cores in order to establish structure-activity relationships with the aim to create better therapeutic agents become available. ..
  12. NOVEL SYNTHETIC APPROACHES TO ANTITUMOR COMPOUNDS
    BARRY TROST; Fiscal Year: 1992
    ..A strategy to one family of tumor promoters represented by teleocidin explores the concept of chemical chameleons. In most cases, the strategy also considers the problem of absolute stereochemistry...
  13. NOVEL APPROACHES TO ANTITUMOR AND ANTIVIRAL AGENTS
    BARRY TROST; Fiscal Year: 1993
    ..The diversity of the challenges posed by antiviral and antitumor agents represent highly meaningful tests of their use...
  14. NMR systems : 2 Bruker Avance 500 Consoles
    AMOS SMITH; Fiscal Year: 2006
    ..The areas of public health research include, among others, cancer, infectious diseases, neurodegenerative diseases such as Alzheimer's disease, and heart and cardiovascular disease. ..
  15. Pilot-Scale Libraries for High-throughput Screening
    AMOS SMITH; Fiscal Year: 2007
    ....
  16. CATALYTIC ENANTIOSELECTIVE OLEFIN METATHESIS REACTIONS
    Richard Schrock; Fiscal Year: 2003
    ..Both AROM followed by RCM, and AROM followed by intermolecular cross- metathesis, will be developed as efficient methods for catalytic enantioselective synthesis. ..
  17. PRO-LEU-GLY-NH2 AND DOPAMINE RECEPTOR MODULATION STUDY
    Rodney Johnson; Fiscal Year: 1993
    ....
  18. COMBINATORIAL APPROACHES TO ANTI-SMALLPOX AGENTS
    Michael Pirrung; Fiscal Year: 2003
    ....
  19. BIOORGANIC CHEMISTRY OF ANTIBACTERIALS
    Michael Pirrung; Fiscal Year: 2001
    ..An ancillary benefit of this project will be the development of novel techniques in solid phase synthesis through the total synthesis of natural products. ..
  20. Medicinal Chemistry and Biology of Oral Insulin Mimics
    Michael Pirrung; Fiscal Year: 2006
    ..They would therefore increase the reliability of diabetes management, particularly for children. ..
  21. CHEMISTRY-BIOLOGY INTERFACE TRAINING PROGRAM
    Michael Pirrung; Fiscal Year: 2003
    ..It is intended to train future leaders in pharmaceutical, medical, and biotechnological research to serve in academia, government, and industry. ..