alkanes

Summary

Summary: The generic name for the group of aliphatic hydrocarbons Cn-H2n+2. They are denoted by the suffix -ane. (Grant & Hackh's Chemical Dictionary, 5th ed)

Top Publications

  1. ncbi Microbial biosynthesis of alkanes
    Andreas Schirmer
    LS9, Inc, 600 Gateway Boulevard, South San Francisco, CA 94080, USA
    Science 329:559-62. 2010
  2. pmc Detection of formate, rather than carbon monoxide, as the stoichiometric coproduct in conversion of fatty aldehydes to alkanes by a cyanobacterial aldehyde decarbonylase
    Douglas M Warui
    Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States
    J Am Chem Soc 133:3316-9. 2011
  3. ncbi Alkane hydroxylases involved in microbial alkane degradation
    Jan B van Beilen
    Département de Biologie Moléculaire Végétale, Le Biophore, Quartier Sorge, Universite de Lausanne, 1015, Lausanne, Switzerland
    Appl Microbiol Biotechnol 74:13-21. 2007
  4. pmc CYP63A2, a catalytically versatile fungal P450 monooxygenase capable of oxidizing higher-molecular-weight polycyclic aromatic hydrocarbons, alkylphenols, and alkanes
    Khajamohiddin Syed
    Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Appl Environ Microbiol 79:2692-702. 2013
  5. pmc The quantitative significance of Syntrophaceae and syntrophic partnerships in methanogenic degradation of crude oil alkanes
    N D Gray
    School of Civil Engineering and Geosciences, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK
    Environ Microbiol 13:2957-75. 2011
  6. pmc Anaerobic initial reaction of n-alkanes in a denitrifying bacterium: evidence for (1-methylpentyl)succinate as initial product and for involvement of an organic radical in n-hexane metabolism
    R Rabus
    Max Planck Institut für Marine Mikrobiologie, D 28359 Bremen, Germany
    J Bacteriol 183:1707-15. 2001
  7. ncbi Diversity of flavin-binding monooxygenase genes (almA) in marine bacteria capable of degradation long-chain alkanes
    Wanpeng Wang
    Key Laboratory of Marine Biogenetic Resources, The Third Institute of Oceanography, State of Oceanic Administration, Xiamen, China
    FEMS Microbiol Ecol 80:523-33. 2012
  8. ncbi Crude-oil biodegradation via methanogenesis in subsurface petroleum reservoirs
    D M Jones
    School of Civil Engineering and Geosciences, University of Newcastle, Newcastle upon Tyne, NE1 7RU, UK
    Nature 451:176-80. 2008
  9. ncbi Multiple alkane hydroxylase systems in a marine alkane degrader, Alcanivorax dieselolei B-5
    Chenli Liu
    Key Lab of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration, China
    Environ Microbiol 13:1168-78. 2011
  10. ncbi Analyses of n-alkanes degrading community dynamics of a high-temperature methanogenic consortium enriched from production water of a petroleum reservoir by a combination of molecular techniques
    Lei Zhou
    State Key Laboratory of Bioreactor Engineering, Institute of Applied Chemistry, East China University of Science and Technology, Shanghai, People s Republic of China
    Ecotoxicology 21:1680-91. 2012

Research Grants

  1. NYU Lung Cancer Biomarker Center
    William N Rom; Fiscal Year: 2013
  2. HEME PROTEIN REDUCTASES
    Stephen G Sligar; Fiscal Year: 2012
  3. High-Spin Iron(IV)-oxo Complexes-True Mimics of Enzymatic Non-Heme Iron
    AIDAN RICHARD MCDONALD; Fiscal Year: 2010
  4. Does Anesthetic Solubility Determine Receptor Specificity?
    ROBERT JOSEPH BROSNAN; Fiscal Year: 2013
  5. Characterizing the structure of alkane hydroxylase (AlkB) and related diiron enzy
    RACHEL NAREHOOD AUSTIN; Fiscal Year: 2013
  6. Structural Elucidation, Synthesis and Study of the Chlorosulfolipids
    Christopher D Vanderwal; Fiscal Year: 2013
  7. A BREATH TEST FOR LUNG CANCER
    Michael Phillips; Fiscal Year: 2009
  8. Molecular Insight into Toxicant Degradation by Microbial Communities
    Gerben Zylstra; Fiscal Year: 2009
  9. BIOCHEMISTRY OF NATURAL PRODUCTS
    Pappachan Kolattukudy; Fiscal Year: 1991
  10. EFFECTS OF GENERAL ANESTHETICS ON NICOTINIC MEMBRANES
    Leonard Firestone; Fiscal Year: 1991

Detail Information

Publications270 found, 100 shown here

  1. ncbi Microbial biosynthesis of alkanes
    Andreas Schirmer
    LS9, Inc, 600 Gateway Boulevard, South San Francisco, CA 94080, USA
    Science 329:559-62. 2010
    b>Alkanes, the major constituents of gasoline, diesel, and jet fuel, are naturally produced by diverse species; however, the genetics and biochemistry behind this biology have remained elusive...
  2. pmc Detection of formate, rather than carbon monoxide, as the stoichiometric coproduct in conversion of fatty aldehydes to alkanes by a cyanobacterial aldehyde decarbonylase
    Douglas M Warui
    Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States
    J Am Chem Soc 133:3316-9. 2011
    The second of two reactions in a recently discovered pathway through which saturated fatty acids are converted to alkanes (and unsaturated fatty acids to alkenes) in cyanobacteria entails scission of the C1-C2 bond of a fatty aldehyde ..
  3. ncbi Alkane hydroxylases involved in microbial alkane degradation
    Jan B van Beilen
    Département de Biologie Moléculaire Végétale, Le Biophore, Quartier Sorge, Universite de Lausanne, 1015, Lausanne, Switzerland
    Appl Microbiol Biotechnol 74:13-21. 2007
    ..The availability of a growing collection of alkane hydroxylase gene sequences now allows estimations of the relative abundance of the different enzyme systems and the distribution of the host organisms...
  4. pmc CYP63A2, a catalytically versatile fungal P450 monooxygenase capable of oxidizing higher-molecular-weight polycyclic aromatic hydrocarbons, alkylphenols, and alkanes
    Khajamohiddin Syed
    Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Appl Environ Microbiol 79:2692-702. 2013
    ..HMW-PAHs), endocrine-disrupting long-chain alkylphenols (APs), and crude oil aliphatic hydrocarbon n-alkanes. A homology-based three-dimensional (3D) model revealed the presence of an extraordinarily large active-site ..
  5. pmc The quantitative significance of Syntrophaceae and syntrophic partnerships in methanogenic degradation of crude oil alkanes
    N D Gray
    School of Civil Engineering and Geosciences, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK
    Environ Microbiol 13:2957-75. 2011
    ..doubling times (36 days for both Smithella and Marinobacter) were determined using qPCR and quantitative data on alkanes, which were the predominant hydrocarbons degraded. The growth yield of the Smithella sp. [0...
  6. pmc Anaerobic initial reaction of n-alkanes in a denitrifying bacterium: evidence for (1-methylpentyl)succinate as initial product and for involvement of an organic radical in n-hexane metabolism
    R Rabus
    Max Planck Institut für Marine Mikrobiologie, D 28359 Bremen, Germany
    J Bacteriol 183:1707-15. 2001
    A novel type of denitrifying bacterium (strain HxN1) with the capacity to oxidize n-alkanes anaerobically with nitrate as the electron acceptor to CO(2) formed (1-methylpentyl)succinate (MPS) during growth on n-hexane as the only organic ..
  7. ncbi Diversity of flavin-binding monooxygenase genes (almA) in marine bacteria capable of degradation long-chain alkanes
    Wanpeng Wang
    Key Laboratory of Marine Biogenetic Resources, The Third Institute of Oceanography, State of Oceanic Administration, Xiamen, China
    FEMS Microbiol Ecol 80:523-33. 2012
    Many bacteria have been reported as degraders of long-chain (LC) n-alkanes, but the mechanism is poorly understood...
  8. ncbi Crude-oil biodegradation via methanogenesis in subsurface petroleum reservoirs
    D M Jones
    School of Civil Engineering and Geosciences, University of Newcastle, Newcastle upon Tyne, NE1 7RU, UK
    Nature 451:176-80. 2008
    ..The initial preferential removal of n-alkanes generates close to stoichiometric amounts of methane, principally by hydrogenotrophic methanogenesis...
  9. ncbi Multiple alkane hydroxylase systems in a marine alkane degrader, Alcanivorax dieselolei B-5
    Chenli Liu
    Key Lab of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration, China
    Environ Microbiol 13:1168-78. 2011
    Alcanivorax dieselolei strain B-5 is a marine bacterium that can utilize a broad range of n-alkanes (C(5) -C(36) ) as sole carbon source. However, the mechanisms responsible for this trait remain to be established...
  10. ncbi Analyses of n-alkanes degrading community dynamics of a high-temperature methanogenic consortium enriched from production water of a petroleum reservoir by a combination of molecular techniques
    Lei Zhou
    State Key Laboratory of Bioreactor Engineering, Institute of Applied Chemistry, East China University of Science and Technology, Shanghai, People s Republic of China
    Ecotoxicology 21:1680-91. 2012
    ..from high-temperature oil reservoir production water and incubated at 55 °C with a mixture of long chain n-alkanes (C(15)-C(20)) as the sole carbon and energy sources was characterized...
  11. ncbi An ab initio study on the torsional surface of alkanes and its effect on molecular simulations of alkanes and a DPPC bilayer
    Jeffery B Klauda
    Laboratory of Biophysical Chemistry, National Institutes of Health, Building 50, 50 South Drive, Bethesda, Maryland 20892, USA
    J Phys Chem B 109:5300-11. 2005
    Energies of 119 conformations of normal alkanes from butane to heptane were calculated at approximately the CCSD(T)/cc-pVQZ level. Energies of gauche (g) conformers relative to trans (t) decrease as chain length increases...
  12. ncbi Analysis of alkane-dependent methanogenic community derived from production water of a high-temperature petroleum reservoir
    Serge Maurice Mbadinga
    State Key Laboratory of Bioreactor Engineering and Institute of Applied Chemistry, East China University of Science and Technology, Shanghai, 200237, China
    Appl Microbiol Biotechnol 96:531-42. 2012
    Microbial assemblage in an n-alkanes-dependent thermophilic methanogenic enrichment cultures derived from production waters of a high-temperature petroleum reservoir was investigated in this study...
  13. ncbi Genes involved in alkane degradation in the Alcanivorax hongdengensis strain A-11-3
    Wanpeng Wang
    The Third Institute of Oceanography, State Oceanic Administration, Xiamen, China
    Appl Microbiol Biotechnol 94:437-48. 2012
    ..type strain isolated from the surface water of the Malacca and Singapore Straits that can degrade a wide range of alkanes. To understand the degradation mechanism of this strain, the genes encoding alkane hydroxylases were obtained by ..
  14. ncbi Task group differences in cuticular lipids in the honey bee Apis mellifera
    Ricarda Kather
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield, UK
    J Chem Ecol 37:205-12. 2011
    ..as our model species, we investigated the presence of task-specific patterns in the cuticular lipids (n-alkanes, fatty acids, and alkenes) of bees...
  15. ncbi Genes encoding the candidate enzyme for anaerobic activation of n-alkanes in the denitrifying bacterium, strain HxN1
    Olav Grundmann
    Max Planck Institut für Marine Mikrobiologie, Celsiusstrasse 1, D 28359 Bremen, Germany
    Environ Microbiol 10:376-85. 2008
    Strain HxN1, a member of the Betaproteobacteria, can grow anaerobically by denitrification with n-alkanes. n-Alkanes are apparently activated by subterminal carbon addition to fumarate yielding (1-methylalkyl)succinates, the postulated ..
  16. ncbi Anaerobic biodegradation of longer-chain n-alkanes coupled to methane production in oil sands tailings
    Tariq Siddique
    Department of Renewable Resources, University of Alberta, Edmonton, Alberta T6G 2E3, Canada
    Environ Sci Technol 45:5892-9. 2011
    ..Our previous studies revealed that certain hydrocarbons (short-chain n-alkanes [C(6)-C(10)] and monoaromatics [toluene, o-xylene, m-xylene]) in residual naphtha entrained in the tailings are ..
  17. pmc Involvement of an alkane hydroxylase system of Gordonia sp. strain SoCg in degradation of solid n-alkanes
    Luca Lo Piccolo
    Dipartimento di Biologia Cellulare e dello Sviluppo, Viale delle Scienze edif 16, 90128 Palermo, Italy
    Appl Environ Microbiol 77:1204-13. 2011
    Enzymes involved in oxidation of long-chain n-alkanes are still not well known, especially those in gram-positive bacteria. This work describes the alkane degradation system of the n-alkane degrader actinobacterium Gordonia sp...
  18. ncbi Microbial production of short-chain alkanes
    Yong Jun Choi
    Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering BK21 Program, BioProcess Engineering Research Center and Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, Korea Advanced Institute of Science and Technology KAIST, 291 Daehak ro, Yuseong Gu, Daejeon 305 701, South Korea
    Nature 502:571-4. 2013
    ..Here we report the development of platform Escherichia coli strains that are capable of producing short-chain alkanes (SCAs; petrol), free fatty acids (FFAs), fatty esters and fatty alcohols through the fatty acyl (acyl carrier ..
  19. ncbi Isolation and characterization of a novel thermophilic Bacillus strain degrading long-chain n-alkanes
    Lei Wang
    TEDA School of Biological Sciences and Biotechnology, Nankai University, 23 Hong Da Street, TEDA, 300457, Tianjin, People s Republic of China
    Extremophiles 10:347-56. 2006
    ..Further examination showed that NG80-2 degraded and utilized only long-chain (C15-C36) n-alkanes, but not short-chain (C8-C14) n-alkanes and those longer than C40...
  20. ncbi Understanding and exploiting C-H bond activation
    Jay A Labinger
    Arnold and Mabel Beckman Laboratories of Chemical Synthesis, California Institute of Technology, Pasadena, California 91125, USA
    Nature 417:507-14. 2002
    ..synthesis to the replacement of current petrochemical feedstocks by less expensive and more readily available alkanes. The past twenty years have seen many examples of C-H bond activation at transition-metal centres, often under ..
  21. pmc Cytochrome P450 alkane hydroxylases of the CYP153 family are common in alkane-degrading eubacteria lacking integral membrane alkane hydroxylases
    Jan B van Beilen
    Institute of Biotechnology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Appl Environ Microbiol 72:59-65. 2006
    Several strains that grow on medium-chain-length alkanes and catalyze interesting hydroxylation and epoxidation reactions do not possess integral membrane nonheme iron alkane hydroxylases...
  22. ncbi Degradation of alkanes by bacteria
    Fernando Rojo
    Departamento de Biotecnologia Microbiana, Centro Nacional de Biotecnologia, CSIC, Campus de la Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Environ Microbiol 11:2477-90. 2009
    ..Crude oil is a complex mixture of thousands of compounds. Among them, alkanes constitute the major fraction. Alkanes are saturated hydrocarbons of different sizes and structures...
  23. pmc Bioenergy production via microbial conversion of residual oil to natural gas
    Lisa M Gieg
    Department of Botany and Microbiology, Institute for Energy and the Environment, University of Oklahoma, Norman, Oklahoma 73019, USA
    Appl Environ Microbiol 74:3022-9. 2008
    ..The anaerobic biodegradation of n-alkanes to methane gas has now been documented in a few studies, and it was speculated that this process might be useful ..
  24. ncbi Anaerobic biodegradation of saturated and aromatic hydrocarbons
    F Widdel
    Max Planck Institut für Marine Mikrobiologie, Celsiusstrasse 1, D 28359, Bremen, Germany
    Curr Opin Biotechnol 12:259-76. 2001
    ..During the past decade, however, an increasing number of microorganisms have been detected that degrade hydrocarbons under strictly anoxic conditions...
  25. pmc Identification of novel genes involved in long-chain n-alkane degradation by Acinetobacter sp. strain DSM 17874
    Mimmi Throne-Holst
    SINTEF Materials and Chemistry, Department of Biotechnology, Norwegian University of Science and Technology, Sem Saelandsvei 2A, 7465 Trondheim, Norway
    Appl Environ Microbiol 73:3327-32. 2007
    Acinetobacter sp. strain DSM 17874 is capable of utilizing n-alkanes with chain lengths ranging from that of decane (C10H22) to that of tetracontane (C40H82) as a sole carbon source...
  26. pmc Two novel alkane hydroxylase-rubredoxin fusion genes isolated from a Dietzia bacterium and the functions of fused rubredoxin domains in long-chain n-alkane degradation
    Yong Nie
    Department of Energy and Resources Engineering, College of Engineering, Peking University, Beijing 100871, PR China
    Appl Environ Microbiol 77:7279-88. 2011
    ..alkW1 and alkW2) were cloned from a Dietzia strain, designated DQ12-45-1b, which can grow on crude oil and n-alkanes ranging in length from 6 to 40 carbon atoms as sole carbon sources...
  27. ncbi Multitargeted drugs discovery: balancing anti-amyloid and anticholinesterase capacity in a single chemical entity
    Maria Laura Bolognesi
    Department of Pharmaceutical Sciences Alma Mater Studiorum Bologna University, Via Belmeloro 6, 40126 Bologna, Italy
    Bioorg Med Chem Lett 21:2655-8. 2011
    ..By properly combining two or more distinct pharmacological properties in a molecule, we can achieve greater effectiveness compared to single-targeted drugs for investigating AD...
  28. pmc Probing the mechanism of cyanobacterial aldehyde decarbonylase using a cyclopropyl aldehyde
    Bishwajit Paul
    Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Am Chem Soc 135:5234-7. 2013
    ..aldehyde decarbonylase (cAD) is a non-heme diiron oxygenase that catalyzes the conversion of fatty aldehydes to alkanes and formate. The mechanism of this chemically unusual reaction is poorly understood...
  29. pmc A process for microbial hydrocarbon synthesis: Overproduction of fatty acids in Escherichia coli and catalytic conversion to alkanes
    Rebecca M Lennen
    Department of Chemical and Biological Engineering, University of Wisconsin Madison, Madison Wisconsin, USA
    Biotechnol Bioeng 106:193-202. 2010
    ..phase and fed to a Pd/C plug flow reactor, where the extracted fatty acids were decarboxylated into saturated alkanes. The result is an enriched alkane stream that can be recycled for continuous extractions...
  30. ncbi Thermodynamic constraints on methanogenic crude oil biodegradation
    Jan Dolfing
    School of Civil Engineering and Geosciences, Newcastle University, Newcastle upon Tyne, UK
    ISME J 2:442-52. 2008
    ..There are several possible routes whereby hydrocarbons may be converted to methane: (i) complete oxidation of alkanes to H2 and CO2, linked to methanogenesis from CO2 reduction; (ii) oxidation of alkanes to acetate and H2, linked ..
  31. pmc Production of propane and other short-chain alkanes by structure-based engineering of ligand specificity in aldehyde-deformylating oxygenase
    Basile Khara
    Manchester Institute of Biotechnology and Faculty of Life Sciences, University of Manchester, 131 Princess Street, Manchester M1 7DN, UK
    Chembiochem 14:1204-8. 2013
    ..This presents new opportunities for developing biocatalytic modules for the production of volatile "drop-in" biofuels. ..
  32. ncbi Microbial communities involved in methane production from hydrocarbons in oil sands tailings
    Tariq Siddique
    Department of Renewable Resources, University of Alberta, Edmonton, AB, Canada
    Environ Sci Technol 46:9802-10. 2012
    Microbial metabolism of residual hydrocarbons, primarily short-chain n-alkanes and certain monoaromatic hydrocarbons, in oil sands tailings ponds produces large volumes of CH(4) in situ...
  33. pmc Cyanobacterial alkane biosynthesis further expands the catalytic repertoire of the ferritin-like 'di-iron-carboxylate' proteins
    Carsten Krebs
    Department of Chemistry, Penn State University, 332 Chemistry Building, University Park, PA 16802, USA
    Curr Opin Chem Biol 15:291-303. 2011
    ....
  34. ncbi Degradation of n-alkanes and polycyclic aromatic hydrocarbons in petroleum by a newly isolated Pseudomonas aeruginosa DQ8
    Zhengzhi Zhang
    State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, People s Republic of China
    Bioresour Technol 102:4111-6. 2011
    A bacterial isolate, designated as DQ8, was found capable of degrading diesel, crude oil, n-alkanes and polycyclic aromatic hydrocarbons (PAHs) in petroleum...
  35. ncbi Bacterial metabolism of long-chain n-alkanes
    Alexander Wentzel
    Department of Biotechnology, Norwegian University of Science and Technology, Sem Saelandsvei 6 8, 7491 Trondheim, Norway
    Appl Microbiol Biotechnol 76:1209-21. 2007
    Degradation of alkanes is a widespread phenomenon in nature, and numerous microorganisms, both prokaryotic and eukaryotic, capable of utilizing these substrates as a carbon and energy source have been isolated and characterized...
  36. pmc Anaerobic transformation of alkanes to fatty acids by a sulfate-reducing bacterium, strain Hxd3
    Chi Ming So
    Biotechnology Center for Agriculture and the Environment, Cook College, Rutgers, The State University of New Jersey, 59 Dudley Road, New Brunswick, NJ 08901 8520, USA
    Appl Environ Microbiol 69:3892-900. 2003
    ..grown on perdeuterated pentadecane and [1,2-(13)C(2)]hexadecane, respectively, underscoring evidence that C-odd alkanes are transformed to C-even fatty acids and vice versa...
  37. ncbi Biodegradation of short-chain n-alkanes in oil sands tailings under methanogenic conditions
    Tariq Siddique
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada
    Environ Sci Technol 40:5459-64. 2006
    The biodegradation of a mixture of low molecular weight n-alkanes (C6, C7, C8, and C10) was assessed under methanogenic conditions using mature fine tailings (MFT) produced by the oil sands industry in Alberta, Canada...
  38. ncbi Volatile organic compounds released by the entomopathogenic fungus Beauveria bassiana
    R Crespo
    Instituto de Investigaciones Bioquimicas de La Plata, CONICET, UNLP, Facultad de Ciencias Medicas, calles 60 y 120, La Plata, 1900, Argentina
    Microbiol Res 163:148-51. 2008
    ..Alkane-grown fungal VOC switched to a fingerprint with prevalence of n-decane. This is the first report on the volatiles released by entomopathogenic fungi...
  39. ncbi Molecular screening for alkane hydroxylase genes in Gram-negative and Gram-positive strains
    T H Smits
    Institute of Biotechnology, ETH Honggerberg, Zurich, Switzerland
    Environ Microbiol 1:307-17. 1999
    ..all Gram-negative and in two out of three Gram-positive strains able to grow on medium- (C6-C11) or long-chain n-alkanes (C12-C16), PCR products of the expected size were obtained...
  40. ncbi Exhaled markers of inflammatory lung diseases: ready for routine monitoring?
    Sergei A Kharitonov
    National Heart and Lung Institute, Imperial College, Royal Brompton Hospital, London, UK
    Swiss Med Wkly 134:175-92. 2004
    ..The article reviews whether current noninvasive measurements of exhaled gases, such as nitric oxide (NO), hydrocarbons, inflammatory markers exhaled breath condensate (EBC) are ready for routine use in clinical practice...
  41. pmc Stereoselective microbial dehalorespiration with vicinal dichlorinated alkanes
    Stefaan De Wildeman
    Laboratory for Microbial Ecology and Technology, Ghent University, B 9000 Ghent, Belgium
    Appl Environ Microbiol 69:5643-7. 2003
    ..This unique dehalorespiratory biochemistry has shown promising application possibilities for bioremediation purposes and fine-chemical synthesis...
  42. ncbi Efficient stereo- and regioselective hydroxylation of alkanes catalysed by a bulky polyoxometalate
    Keigo Kamata
    Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8656, Japan
    Nat Chem 2:478-83. 2010
    Direct functionalization of alkanes by oxidation of C-H bonds to form alcohols under mild conditions is a challenge for synthetic chemistry...
  43. ncbi In-injection port thermal desorption and subsequent gas chromatography-mass spectrometric analysis of polycyclic aromatic hydrocarbons and n-alkanes in atmospheric aerosol samples
    Steven Sai Hang Ho
    Department of Chemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    J Chromatogr A 1059:121-9. 2004
    ..We describe here an alternative approach for the analysis of aerosol alkanes and polycyclic aromatic hydrocarbons (PAHs) that obviates the use of solvents...
  44. ncbi Compound-specific deltaD-delta13C analyses of n-alkanes extracted from terrestrial and aquatic plants
    Yoshito Chikaraishi
    Department of Chemistry, Tokyo Metropolitan University, 1 1, Minami Ohsawa, Hachioji, 192 0397, Tokyo, Japan
    Phytochemistry 63:361-71. 2003
    Stable hydrogen and carbon isotopic compositions of individual n-alkanes were determined for various terrestrial plants (33 samples including 27 species) and aquatic plants (six species) in natural environments from Japan and Thailand...
  45. ncbi Packing properties of 1-alkanols and alkanes in a phospholipid membrane
    Thomas H Aagaard
    Department of Life Science and Chemistry, Roskilde University PO Box 260, DK 4000 Roskilde, Denmark
    Biophys Chem 119:61-8. 2006
    We have used vibrating tube densitometry to investigate the packing properties of four alkanes and a homologous series of ten alcohols in fluid-phase membranes of dimyristoyl phosphatidylcholine (DMPC)...
  46. ncbi Catalytic dehydroaromatization of n-alkanes by pincer-ligated iridium complexes
    Ritu Ahuja
    Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, USA
    Nat Chem 3:167-71. 2011
    ..Benzene, toluene and xylenes are obtained from the high temperature thermolysis of alkanes. Higher alkylaromatics are generally derived from arene-olefin coupling, which gives branched products--that is, ..
  47. ncbi Secondary organic aerosol formation from intermediate-volatility organic compounds: cyclic, linear, and branched alkanes
    Daniel S Tkacik
    Center for Atmospheric Particle Studies, Carnegie Mellon University, Pittsburgh, PA, USA
    Environ Sci Technol 46:8773-81. 2012
    ..as an unresolved complex mixture (UCM) that is presumably made up of a complex mixture of branched and cyclic alkanes. To better understand SOA formation from IVOCs, a series of smog chamber experiments was conducted with different ..
  48. ncbi Biosynthetic origin of the saw-toothed profile in delta(13)C and delta(2)H of n-alkanes and systematic isotopic differences between n-, iso- and anteiso-alkanes in leaf waxes of land plants
    Youping Zhou
    RSB, Australian National University, Canberra, ACT 2601, Australia
    Phytochemistry 71:388-403. 2010
    ..The n-alkanes containing an odd number of carbon atoms (OCN-n-alkanes) are generally formed by the decarboxylation of ECN-n-FAs,..
  49. ncbi Influence of biosurfactants produced by Candida antarctica on surface properties of microorganism and biodegradation of n-alkanes
    Zhaozhe Hua
    School of Biotechnology, Southern Yangtze University Wuxi University of Light Industry, 214036 Wuxi, China
    Water Res 37:4143-50. 2003
    ..that the addition of BS-UC influenced positively the emulsification and the biodegradation of a variety of n-alkanes substrates...
  50. ncbi Regioselective ω-hydroxylation of medium-chain n-alkanes and primary alcohols by CYP153 enzymes from Mycobacterium marinum and Polaromonas sp. strain JS666
    Daniel Scheps
    Institute of Technical Biochemistry, Universitaet Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
    Org Biomol Chem 9:6727-33. 2011
    ..systems yielded primary alcohols and α,ω-alkanediols, each one displayed a different oxidation pattern towards alkanes. For CYP153A P. sp...
  51. ncbi Volatile components of the cyanobacterium Oscillatoria perornata (Skuja)
    M R Tellez
    Natural Products Utilization Research Unit, Agricultural Research Service, U S Department of Agriculture, Box 8048, Oxford, Mississippi 38677, USA
    J Agric Food Chem 49:5989-92. 2001
    ..0%), dimethyl trisulfide (0.5%), and benzothiazole (0.6%). These compounds and their organoleptic characteristics are discussed in relation to their possible contributions to cultured catfish off-flavor problems...
  52. pmc n-Alkane chain length alters Dietzia sp. strain DQ12-45-1b biosurfactant production and cell surface activity
    Xing Biao Wang
    Department of Energy and Resources Engineering, College of Engineering, Peking University, Beijing, People s Republic of China
    Appl Environ Microbiol 79:400-2. 2013
    ..These results suggest that the mechanisms of biosurfactant production and cell surface hydrophobicity are dependent upon the chain lengths of the n-alkanes used as carbon sources.
  53. ncbi Soluble methane monooxygenase: activation of dioxygen and methane
    Daniel A Kopp
    Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room 18 498, Cambridge 02139, USA
    Curr Opin Chem Biol 6:568-76. 2002
    ..techniques have clarified subtle details about each step in the reaction, from binding and activating dioxygen, to hydroxylation of alkanes and other substrates, to the electron transfer events required to complete the catalytic cycle.
  54. ncbi Transcriptional profiling of the marine oil-degrading bacterium Alcanivorax borkumensis during growth on n-alkanes
    Julia S Sabirova
    Department of Bioscience and Bioengineering, Ghent University, Ghent, Belgium
    FEMS Microbiol Lett 319:160-8. 2011
    ..Among the genes upregulated on alkanes are systems predicted to be involved in the terminal oxidation of alkanes, biofilm formation, signal transduction,..
  55. ncbi Anaerobic utilization of alkylbenzenes and n-alkanes from crude oil in an enrichment culture of denitrifying bacteria affiliating with the beta-subclass of Proteobacteria
    R Rabus
    Max Planck Institut für Marine Mikrobiologie, Bremen, Germany
    Environ Microbiol 1:145-57. 1999
    ..the first phase, bacteria grew homogeneously in the aqueous phase, while various C1-C3 alkylbenzenes, but no alkanes, were utilized from the crude oil...
  56. ncbi Determination of ethane, pentane and isoprene in exhaled air using a multi-bed adsorbent and end-cut gas-solid chromatography
    Mona Lärstad
    Department of Occupational Medicine, The Sahlgrenska Academy at Goteborg University, Sweden
    Analyst 127:1440-5. 2002
    ..1+/-5.8 pmol l(-1), 11+/-5.8 pmol l(-1) and 2.4+/-0.90 mnol l(-1), respectively. The method could, with minor modifications, be used to determine other low-molecular hydrocarbons in exhaled air as well...
  57. pmc Genome sequence of Pseudomonas aeruginosa DQ8, an efficient degrader of n-alkanes and polycyclic aromatic hydrocarbons
    Zhonghui Gai
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    J Bacteriol 194:6304-5. 2012
    ..from the crude oil polluted soil in the Daqing oilfield of China, can efficiently degrade diesel, crude oil, n-alkanes, and polycyclic aromatic hydrocarbons (PAHs). Here, we present a 6.8-Mb assembly of its genome sequence...
  58. ncbi Volatile alkanes and increased concentrations of isoprene in exhaled air during hemodialysis
    E Capodicasa
    Institute of Internal Medicine and Oncological Sciences, Perugia University, Perugia, Italy
    Nephron 82:331-7. 1999
    ..We assessed both C(2)-C(5) alkanes - among them ethane and pentane the production of which in man is essentially due to the action free radicals ..
  59. pmc Wax ester production from n-alkanes by Acinetobacter sp. strain M-1: ultrastructure of cellular inclusions and role of acyl coenzyme A reductase
    Takeru Ishige
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa, Sakyo ku, Kyoto 606 8502, Japan
    Appl Environ Microbiol 68:1192-5. 2002
    ..The contribution of acyl-CoA reductase to wax ester synthesis was evaluated by gene disruption analysis...
  60. ncbi Degradation of polycyclic aromatic hydrocarbons and long chain alkanes at 60-70 degrees C by Thermus and Bacillus spp [corrected]
    Heiko Feitkenhauer
    Laboratory of Chemical Engineering and Industrial Chemistry, ETH Zurich, Honggerberg, Building HCI F106, CH 8093 Zurich, Switzerland
    Biodegradation 14:367-72. 2003
    Although polycyclic aromatic hydrocarbons (PAH) and alkanes are biodegradable at ambient temperature, in some cases low bioavailabilities are the reason for slow biodegradation...
  61. ncbi Multitarget-directed ligands: innovative chemical probes and therapeutic tools against Alzheimer's disease
    Maria Laura Bolognesi
    Department of Pharmaceutical Sciences, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    Curr Top Med Chem 11:2797-806. 2011
    ..Herein, we discuss several examples of both types of compounds, taken from our own research and derived from the leads memoquin, lipocrine and bis(7)tacrine...
  62. pmc Compounds that block both intermediate-conductance (IK(Ca)) and small-conductance (SK(Ca)) calcium-activated potassium channels
    M Malik-Hall
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK
    Br J Pharmacol 129:1431-8. 2000
    ..1+/-0.2 nM). 7. The main outcome is the identification of new intermediate-conductance Ca(2+)-activated K(+) channel blockers with a wide range of IK(Ca)/SK(Ca) selectivities...
  63. pmc Selective hydroxylation of alkanes by an extracellular fungal peroxygenase
    Sebastian Peter
    Department of Bio and Environmental Sciences, International Graduate School of Zittau, Zittau, Germany
    FEBS J 278:3667-75. 2011
    ..that the peroxygenase secreted by Agrocybe aegerita catalyzes the H(2)O(2)-dependent hydroxylation of linear alkanes at the 2-position and 3-position with high efficiency, as well as the regioselective monooxygenation of branched ..
  64. ncbi Polarizable empirical force field for alkanes based on the classical Drude oscillator model
    Igor V Vorobyov
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201, USA
    J Phys Chem B 109:18988-99. 2005
    ..In the present work, optimization of parameters for alkanes in a polarizable empirical force field based on a classical Drude oscillator is presented...
  65. ncbi Xenon and halogenated alkanes track putative substrate binding cavities in the soluble methane monooxygenase hydroxylase
    D A Whittington
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Biochemistry 40:3476-82. 2001
    ..The halogenated alkanes bind in two cavities within the alpha-subunit that extend from one surface of the protein to the buried dinuclear ..
  66. ncbi A P450 BM-3 mutant hydroxylates alkanes, cycloalkanes, arenes and heteroarenes
    D Appel
    , , Allmandring 31, D-70459, Stuttgart, Germany
    J Biotechnol 88:167-71. 2001
    ..activity of the triple mutant towards indole, we investigated in a preliminary, but systematic manner several alkanes, alicyclic, aromatic, and heterocyclic compounds, all of which are unaffected by the native enzyme, for their ..
  67. doi Mild and efficient H/D exchange of alkanes based on C-H activation catalyzed by rhodium on charcoal
    Tomohiro Maegawa
    Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, 5 6 1 Mitahora higashi Gifu 502 8585, Japan
    Angew Chem Int Ed Engl 47:5394-7. 2008
  68. ncbi Revised charge equilibration potential for liquid alkanes
    Joseph E Davis
    Department of Chemistry and Biochemistry, University of Delaware, 238 Brown Laboratory Newark, Delaware 19716, USA
    J Phys Chem B 112:8298-310. 2008
    ..compressibilities, constant pressure heat capacities, and NMR T 1 relaxation times for a series of linear alkanes ranging from hexane to pentadecane based on the current revised model...
  69. pmc Identification and characterization of the CYP52 family of Candida tropicalis ATCC 20336, important for the conversion of fatty acids and alkanes to alpha,omega-dicarboxylic acids
    David L Craft
    Biotechnology Group, Cognis Corporation, Cincinnati, Ohio 45232, USA
    Appl Environ Microbiol 69:5983-91. 2003
    Candida tropicalis ATCC 20336 excretes alpha,omega-dicarboxylic acids as a by-product when cultured on n-alkanes or fatty acids as the carbon source...
  70. ncbi A small molecule targeting the multifactorial nature of Alzheimer's disease
    Andrea Cavalli
    Department of Pharmaceutical Sciences, Alma Mater Studiorum, University of Bologna, Via Belmeloro, 6, 40126 Bologna, Italy
    Angew Chem Int Ed Engl 46:3689-92. 2007
  71. ncbi Memoquin: a multi-target-directed ligand as an innovative therapeutic opportunity for Alzheimer's disease
    Maria Laura Bolognesi
    Department of Pharmaceutical Sciences, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy
    Neurotherapeutics 6:152-62. 2009
    ..The in vitro and in vivo biological profile of memoquin demonstrates the suitability of the new strategy for obtaining innovative drug candidates for the treatment of neurodegenerative diseases...
  72. ncbi Scaling of the viscosity of the Lennard-Jones chain fluid model, argon, and some normal alkanes
    Guillaume Galliero
    Laboratoire des Fluides Complexes UPPA CNRS TOTAL, Pau University, BP 1155, 64013 Pau Cedex, France
    J Chem Phys 134:064505. 2011
    ..Lennard-Jones chain fluid (from the monomer to the hexadecamer), then to real fluids, such as argon and normal alkanes. To enlarge noticeably the range of thermodynamics conditions for which these scaling methods are applicable, we ..
  73. pmc Growth of Pseudomonas chloritidismutans AW-1(T) on n-alkanes with chlorate as electron acceptor
    Farrakh Mehboob
    Wageningen University, The Netherlands
    Appl Microbiol Biotechnol 83:739-47. 2009
    ..Here, we report that Pseudomonas chloritidismutans AW-1(T) grows on n-alkanes (ranging from C7 until C12) with chlorate as electron acceptor...
  74. ncbi Iridium bis(phosphinite) p-XPCP pincer complexes: highly active catalysts for the transfer dehydrogenation of alkanes
    Inigo Göttker-Schnetmann
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3290, USA
    J Am Chem Soc 126:1804-11. 2004
    ..1NaOtBu, turnover numbers (TONs) between 1400 and 2200 (up to 72% conversion in TBE) and initial turnover frequencies (TOFs) between 1.6 and 2.4 s(-1) have been observed at 200 degrees C...
  75. pmc Effects of surfactant mixtures, including Corexit 9527, on bacterial oxidation of acetate and alkanes in crude oil
    P Bruheim
    Department of Biotechnology, Faculty of Chemistry and Biology, The Norwegian University of Science and Technology, N 7491 Trondheim, Norway
    Appl Environ Microbiol 65:1658-61. 1999
    ..surfactants, including Corexit 9527, were tested to determine their effects on bacterial oxidation of acetate and alkanes in crude oil by cells pregrown on these substrates...
  76. ncbi Trace determination of airborne polyfluorinated iodine alkanes using multisorbent thermal desorption/gas chromatography/high resolution mass spectrometry
    Ting Ruan
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China
    J Chromatogr A 1217:4439-47. 2010
    ..thermal desorption cartridges has been developed for the determination of volatile neutral polyfluorinated iodine alkanes (PFIs) in airborne samples...
  77. ncbi Degradation of alkanes and highly chlorinated benzenes, and production of biosurfactants, by a psychrophilic Rhodococcus sp. and genetic characterization of its chlorobenzene dioxygenase
    Peter Rapp
    GBF National Research Centre for Biotechnology, Division of Microbiology, Mascheroderweg 1, D 38124 Braunschweig, Germany
    Microbiology 149:2879-90. 2003
    ..Furthermore, the bacterium grew well on a great number of n-alkanes ranging from n-heptane to n-triacontane and on the branched alkane 2,6,10,14-tetramethylpentadecane (pristane) ..
  78. pmc Tapetosomes in Brassica tapetum accumulate endoplasmic reticulum-derived flavonoids and alkanes for delivery to the pollen surface
    Kai Hsieh
    Department of Botany and Plant Sciences, Center for Plant Cell Biology, University of California, Riverside, California 92521, USA
    Plant Cell 19:582-96. 2007
    ..Subcellular fractionation of developing anthers localized both flavonoids and alkanes in tapetosomes...
  79. ncbi Does she smell like a queen? Chemoreception of a cuticular hydrocarbon signal in the ant Pachycondyla inversa
    Patrizia d'Ettorre
    Department of Zoology, University of Regensburg, Universitaetsstrasse 31, 93040 Regensburg, Germany
    J Exp Biol 207:1085-91. 2004
    ..inversa workers react to this key compound. 3,11-diMeC(27) is correlated with ovarian activity and, because it is detected, is likely to assume the role of a fertility signal reflecting the quality of the sender...
  80. ncbi Compressed alkanes in reversible encapsulation complexes
    Dariush Ajami
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Chem 1:87-90. 2009
    Simple alkanes feature fully extended conformations as their lowest-energy shapes but can assume coiled, compressed conformations in small spaces...
  81. pmc Biodegradation of variable-chain-length alkanes at low temperatures by a psychrotrophic Rhodococcus sp
    L G Whyte
    NRC Biotechnology Research Institute, Montreal, Quebec, Canada
    Appl Environ Microbiol 64:2578-84. 1998
    The psychorotrophic Rhodococcus sp. strain Q15 was examined for its ability to degrade individual n-alkanes and diesel fuel at low temperatures, and its alkane catabolic pathway was investigated by biochemical and genetic techniques...
  82. ncbi Rotational relaxation of neutral red in alkanes: effect of solvent size on probe rotation
    M K Singh
    Spectroscopy Division, Bhabha Atomic Research Center, Trombay, Mumbai, India
    Photochem Photobiol 72:438-43. 2000
    Rotational reorientation times of a polar molecule neutral red (NR) have been measured in n-alkanes using steady-state fluorescence depolarization technique...
  83. ncbi Production of liquid alkanes by aqueous-phase processing of biomass-derived carbohydrates
    George W Huber
    Department of Chemical and Biological Engineering, University of Wisconsin at Madison, Madison, WI 53706, USA
    Science 308:1446-50. 2005
    Liquid alkanes with the number of carbon atoms ranging from C7 to C15 were selectively produced from biomass-derived carbohydrates by acid-catalyzed dehydration, which was followed by aldol condensation over solid base catalysts to form ..
  84. ncbi Molecular characterization and expression analysis of a suite of cytochrome P450 enzymes implicated in insect hydrocarbon degradation in the entomopathogenic fungus Beauveria bassiana
    Nicolás Pedrini
    Department of Microbiology and Cell Science, University of Florida, Gainesville, FL 32611, USA
    Microbiology 156:2549-57. 2010
    ..epicuticle or waxy layer comprises a heterogeneous mixture of lipids that include abundant levels of long-chain alkanes, alkenes, wax esters and fatty acids...
  85. ncbi Presence and partitioning behavior of polyfluorinated iodine alkanes in environmental matrices around a fluorochemical manufacturing plant: another possible source for perfluorinated carboxylic acids?
    Ting Ruan
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085
    Environ Sci Technol 44:5755-61. 2010
    ..iodides (PFIs), a group of volatile perfluorinated compounds (PFCs), including four perfluorinated iodine alkanes (FIAs) and three polyfluorinated telomer iodides (FTIs) were confirmed to be present in the environment...
  86. ncbi Selective transport and accumulation of alkanes by Rhodococcus erythropolis S+14He
    In Seon Kim
    Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta T6G 2G6, Canada
    Biotechnol Bioeng 80:650-9. 2002
    Selective transport and accumulation of n-alkanes by Rhodococcus erythropolis S+14He was studied by growing cells on n-hexadecane, n-octadecane or the branched alkane pristane, and on mixtures of hydrocarbons...
  87. ncbi Gas-particle concentration and distribution of n-alkanes and polycyclic aromatic hydrocarbons in the atmosphere of Prato (Italy)
    Alessandra Cincinelli
    Department of Chemistry, University of Florence, Via della Lastruccia, 3, 50019 Sesto Fiorentino, Florence, Italy
    Chemosphere 68:472-8. 2007
    ..Gas-particle partition coefficients (K(p)'s) of n-alkane and PAHs were well correlated with the sub-cooled liquid vapour pressure (P(L)(0)) and indicate stronger sorption of PAHs to aerosol particles compared with n-alkanes.
  88. ncbi Incorporation of semi-fluorinated alkanes in the bilayer of small unilamellar vesicles of phosphatidylserine: impact on fusion kinetics
    Yves Ferro
    Unité de Chimie Moléculaire, Universite de Nice Sophia Antipolis, Faculte des Sciences, Parc Valrose, Nice, France
    Biochim Biophys Acta 1581:11-20. 2002
    Semi-fluorinated alkanes C(n)F(2n+1)C(m)H(2m+1) (FnHm) can be co-dispersed with standard phospholipids to form 'fluorinated' vesicles, i.e. vesicles with an internal fluorinated film within their bilayer membrane...
  89. ncbi Heart allograft rejection: detection with breath alkanes in low levels (the HARDBALL study)
    Michael Phillips
    Menssana Research, Inc Fort Lee, New Jersey, USA
    J Heart Lung Transplant 23:701-8. 2004
    ..Rejection is accompanied by oxidative stress that degrades membrane polyunsaturated fatty acids, evolving alkanes and methylalkanes, which are excreted in the breath as volatile organic compounds (VOCs).
  90. pmc Petroleum ether extract of Cissus quadrangularis (LINN) stimulates the growth of fetal bone during intra uterine developmental period: a morphometric analysis
    Bhagath Kumar Potu
    Department of Anatomy, Kasturba Medical College, Manipal University
    Clinics (Sao Paulo) 63:815-20. 2008
    ..The aim of the present study was to analyze the effect Cissus quadrangularis plant petroleum ether extract on the development of long bones during the intra-uterine developmental stage in rats...
  91. ncbi Chronic toxicity of a mixture of chlorinated alkanes and alkenes in ICR mice
    Fun In Wang
    Department of Veterinary Medicine, College of Agriculture, National Taiwan University, Taipei
    J Toxicol Environ Health A 65:279-91. 2002
    The aim of this study was to determine the chronic toxicity of a mixture of chlorinated alkanes and alkenes (CA) consisting of chloroform, 1,1-dichloroethane, 1,1-dichloroethylene, 1,1,1-trichloroethane, trichloroethylene, and ..
  92. ncbi Very-long-chain secondary alcohols and alkanediols in cuticular waxes of Pisum sativum leaves
    Miao Wen
    Department of Botany, University of British Columbia, Vancouver, Canada V6T 1Z4
    Phytochemistry 67:2494-502. 2006
    ..Based on the isomer compositions, the sequence of biosynthetic steps introducing the hydroxyl functions is discussed...
  93. ncbi Different effects of volatile anesthetics and polyhalogenated alkanes on depolarization-evoked glutamate release in rat cortical brain slices
    H Eilers
    Department of Anesthesia and Perioperative Care, University of California San Francisco, 94143 0648, USA
    Anesth Analg 88:1168-74. 1999
    ..In the present study, we compared the effects of anesthetics and nonanesthetics (halogenated alkanes that disobey the Meyer-Overton hypothesis) on depolarization-evoked glutamate release...
  94. pmc Functional analysis of alkane hydroxylases from gram-negative and gram-positive bacteria
    Theo H M Smits
    Institute of Biotechnology, Swiss Federal Institute of Technology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    J Bacteriol 184:1733-42. 2002
    ..GPo12, were equipped with pGEc47 Delta B, which encodes all proteins necessary for growth on medium-chain-length alkanes (C(6) to C(12)), except a functional alkane hydroxylase. The third host was an alkB knockout derivative of P...
  95. ncbi Utilization of n-alkanes by a newly isolated strain of Acinetobacter venetianus: the role of two AlkB-type alkane hydroxylases
    Mimmi Throne-Holst
    Department of Biotechnology, NTNU, 7491, Trondheim, Norway
    Appl Microbiol Biotechnol 72:353-60. 2006
    A bacterial strain capable of utilizing n-alkanes with chain lengths ranging from decane (C10H22) to tetracontane (C40H82) as a sole carbon source was isolated using a system for screening microorganisms able to grow on paraffin (mixed ..
  96. ncbi Verification of degradation of n-alkanes in diesel oil by Pseudomonas aeruginosa strain WatG in soil microcosms
    Akio Ueno
    Laboratory of Environmental Molecular Biology, Graduate School of Environmental Earth Science, Hokkaido University, Kita ku, Sapporo, Hokkaido, 060 0810, Japan
    Curr Microbiol 52:182-5. 2006
    Degradation of n-alkanes in diesel oil by Pseudomonas aeruginosa strain WatG (WatG) was verified in soil microcosms...
  97. ncbi Isolation and functional analysis of cytochrome P450 CYP153A genes from various environments
    Mitsutoshi Kubota
    Marine Biotechnology Institute, Iwate, Japan
    Biosci Biotechnol Biochem 69:2421-30. 2005
    The cytochrome P450 CYP153 family is thought to mediate the terminal hydroxylation reactions of n-alkanes. We isolated 16 new P450 CYP153A genes (central region) from various environments such as petroleum-contaminated soil and ..
  98. ncbi Assessing the role of alkane hydroxylase genotypes in environmental samples by competitive PCR
    S Heiss-Blanquet
    Département de Biotechnologie et Chimie de la Biomasse, Institut Francais du Petrole, Rueil Malmaison, France
    J Appl Microbiol 99:1392-403. 2005
    ..AlkB genotypes involved in the degradation of short-chain alkanes were quantified in environmental samples in order to assess their occurrence and ecological importance.
  99. pmc Cytokinin receptors are involved in alkamide regulation of root and shoot development in Arabidopsis
    José López-Bucio
    Instituto de Investigaciones Quimico Biologicas, Universidad Michoacana de San Nicolas de Hidalgo, Ciudad Universitaria, CP 58030 Morelia, Michoacan, Mexico
    Plant Physiol 145:1703-13. 2007
    ....
  100. ncbi Practical aspects of chemometrics for oil spill fingerprinting
    Jan H Christensen
    Department of Natural Sciences, Faculty of Life Sciences, Copenhagen University, Thorvaldsensvej 40, 1871 Frederiksberg C, Denmark
    J Chromatogr A 1169:1-22. 2007
    ....
  101. ncbi The structure activity relationship of discodermolide analogues
    Simon J Shaw
    Kosan Biosciences, Inc 3832 Bay Center Place, Hayward, CA 94545, USA
    Mini Rev Med Chem 8:276-84. 2008
    ..The majority of analogues have been generated via modification of the lactone region. This suggests that significant simplifications can be made in this region provided that the lactone moiety is maintained...

Research Grants62

  1. NYU Lung Cancer Biomarker Center
    William N Rom; Fiscal Year: 2013
    ..Exhaled breath predicted lung cancer with high AUC using combinations of alkanes measured in GC/MS...
  2. HEME PROTEIN REDUCTASES
    Stephen G Sligar; Fiscal Year: 2012
    ..for the oxygenation of a plethora of compounds, including cholesterol and steroid structures, long chain alkanes, aromatics, fatty acids, drugs, insecticides, pesticides, critical signaling molecules and carcinogen precursors...
  3. High-Spin Iron(IV)-oxo Complexes-True Mimics of Enzymatic Non-Heme Iron
    AIDAN RICHARD MCDONALD; Fiscal Year: 2010
    ..properties of Fe(IV)-oxo complexes, and detailed investigation of their reactivity properties with inert alkanes (e.g...
  4. Does Anesthetic Solubility Determine Receptor Specificity?
    ROBERT JOSEPH BROSNAN; Fiscal Year: 2013
    ..To this end, we will study the relative NMDA antagonism of 2 homologous inhaled anesthetic hydrocarbons (alkanes) and 2 homologous injectable anesthetic hydrocarbons (propofol and its halogenated analogue) using pharmacologic ..
  5. Characterizing the structure of alkane hydroxylase (AlkB) and related diiron enzy
    RACHEL NAREHOOD AUSTIN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Bacteria readily oxidize alkanes utilizing the metalloenzyme alkane hydroxylase (AlkB) and thus the actions of AlkB represent one of nature's best defenses against the environmental effects of ..
  6. Structural Elucidation, Synthesis and Study of the Chlorosulfolipids
    Christopher D Vanderwal; Fiscal Year: 2013
    ..The chlorosulfolipids, a family of stereochemically complex alkanes that display numerous chlorine-bearing stereogenic centers, represent one particularly intriguing class of ..
  7. A BREATH TEST FOR LUNG CANCER
    Michael Phillips; Fiscal Year: 2009
    ..Volatile products of oxidative stress are generated in all tissues of the body and excreted in the breath as alkanes and methylated alkanes...
  8. Molecular Insight into Toxicant Degradation by Microbial Communities
    Gerben Zylstra; Fiscal Year: 2009
    ..Many new genera and species have recently been described based on organisms isolated for the ability to degrade alkanes. The Kyrgyz Republic represents a region of the world with varied habitats ranging from high mountain deserts, ..
  9. BIOCHEMISTRY OF NATURAL PRODUCTS
    Pappachan Kolattukudy; Fiscal Year: 1991
    Mechanism of biosynthesis of long chain alkanes, alkane diols, 3- hydroxy acids, methyl-branched acids, erythronolide, and wax esters will be elucidated by purification and characterization of the relevant enzymes from meibomian glands, ..
  10. EFFECTS OF GENERAL ANESTHETICS ON NICOTINIC MEMBRANES
    Leonard Firestone; Fiscal Year: 1991
    ..The ability of a chemically and physically diverse group of general anesthetics (e.g. volatiles, alcohols, alkanes, inert gases, fluorinated gases, sterols, long chain alcohols and alkanes) to desensitize the receptor will be ..
  11. Resolutions in Branched Alkanes using Lipase in Beads
    STEVEN NEAU; Fiscal Year: 2002
    ..The solvents are straight chain and methyl-branched alkanes to test the hypothesis that branching can enhance the activity and enantioselectivity of lipase...
  12. NORMAL SKIN LIPID METABOLISM & CORNIFICATION DISORDERS
    Mary Williams; Fiscal Year: 1992
    ..Some diseases are characterized by accumulation of very long chain (v.l.c.) n-alkanes, also found in normal skin...
  13. PATTERNED NEURONAL NETWORKS
    Bruce Wheeler; Fiscal Year: 1991
    ..silicon dioxide insulation with patterns of covalently bonded areas of high (diamines) and low (alkanes) adhesion...
  14. Butane metabolism in Pseudomonas butanovora
    Daniel Arp; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Gaseous and liquid alkanes can serve as bacterial growth substrates. Alkane monooxygenases initiate the metabolism of alkanes by catalyzing the oxidation of the alkanes to alcohols...
  15. EXTENSION OF SOLUTION NMR TO 50 KDA PROTEINS AND BEYOND
    A Wand; Fiscal Year: 2000
    ..Modest pressures ranging up to 50 bar will be required to liquefy these alkanes. Optical spectroscopy under pressure will be employed as a rapid assay...
  16. REACTIVE ALDEHYDE BIOMARKERS OF LIPID PEROXIDATION
    Sidney Nelson; Fiscal Year: 1992
    ..the concentration of these lipid peroxidation products over time in rats and mice after the administration of hepatotoxic doses of halogenated alkanes, and after other treatments and conditions that are known to cause lipid peroxidation.
  17. NEW BIOMARKER OF BREAST CANCER IN BREATH
    Michael Phillips; Fiscal Year: 1999
    ..Polyunsaturated fatty acids are converted to alkanes that are excreted in the breath or degraded by cytochrome p450 enzymes...
  18. NMR systems : 2 Bruker Avance 500 Consoles
    AMOS SMITH; Fiscal Year: 2006
    ..The areas of public health research include, among others, cancer, infectious diseases, neurodegenerative diseases such as Alzheimer's disease, and heart and cardiovascular disease. [unreadable] [unreadable] [unreadable]..
  19. SYNTHESIS OF SPONGISTATIN ANTITUMOR AGENTS
    AMOS SMITH; Fiscal Year: 2007
    ..abstract_text> ..
  20. Design and Synthesis of HIV-1 Protease Inhibitors
    AMOS SMITH; Fiscal Year: 2004
    ....
  21. SYNTHESIS OF CHLOROPEPTINS, GP120 CD4 BINDING INHIBITORS
    AMOS SMITH; Fiscal Year: 2001
    ..abstract_text> ..
  22. VOLATILE MARKERS OF ORAL MALODOR IN THE BREATH
    Michael Phillips; Fiscal Year: 2004
    ....
  23. VOLATILE MARKERS OF PULMONARY TUBERCULOSIS IN THE BREATH
    Michael Phillips; Fiscal Year: 2006
    ..Also, it could potentially reduce the mortality and morbidity caused by pulmonary TB. [unreadable] [unreadable] [unreadable]..
  24. NMR RELAXATION OF LIQUID CRYSTAL SYSTEMS
    Charles Wade; Fiscal Year: 1980
    ..Deuterium NMR will be used to study dynamics in membranes, in cells, and in alkanes dissolved in model membranes.
  25. General Anesthetics and nAcCHOR Agonist Affinity
    Douglas Raines; Fiscal Year: 2004
    ....
  26. Agilent 5973 GC/MS System
    GARY MOLANDER; Fiscal Year: 2002
    ..Our current lack of such instrumentation negatively affects the ability to carry out many of these studies. This critical capability, in the form of an instrument for everyday analysis, is urgently needed. ..
  27. ASSEMBLIES OF SELF COMPLEMENTARY STRUCTURES
    Julius Rebek; Fiscal Year: 2005
    ..We also propose to synthesize new and larger capsules, especially those made up of many identical molecular subunits. ..
  28. STUDIES IN MOLECULAR RECOGNITION
    Julius Rebek; Fiscal Year: 2010
    ..These cavitands could allow the identification of genes whose expression is influenced by trimethylation of particular lysines of the histones. ..
  29. Catalytic Processes for Selective Organic Synthesis
    GARY MOLANDER; Fiscal Year: 2005
    ..4) Carbometalation/cyclization reactions will be explored utilizing organochromium species. 5) Ligands and catalytic systems designed for asymmetric synthesis will be explored. ..
  30. Natural Product Leads for Drug Development
    KATHLYN PARKER; Fiscal Year: 2009
    ..Molecular modeling will allow the design of candidates for more active drugs. Candidates will be evaluated in the squalene synthase assay. Collaborations for the medicinal chemistry components of the project have been arranged. ..
  31. STRATEGIES AND METHODS IN SYNTHESIS OF NATURAL PRODUCTS
    KATHLYN PARKER; Fiscal Year: 2003
    ..During the period which corresponds to this proposal, we plan to apply our new methodology to the synthesis of deacetylravidomycin and kidamycin, representatives of the remaining two major classes. ..
  32. Ensemble coding in olfactory cortex
    Donald Wilson; Fiscal Year: 2006
    ..This combination is ideally suited for the R21 mechanism. ..
  33. UMKC School of Dentistry Oral and Craniofacial Biology
    J Eick; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  34. New Methods for the Synthesis of Neurological Agents
    LARRY OVERMAN; Fiscal Year: 2008
    ..oryzae at 90 nM, suggesting potential antitumor activity. Because of the scarcity of these natural products from their natural sources, little biological evaluation has been carried out. ..
  35. PRACTICAL CHEMICAL SYNTHESIS OF COMPLEX ALKALOIDS
    LARRY OVERMAN; Fiscal Year: 2009
    ....
  36. New Fluorous Tags for Combinatorial Synthesis
    MARVIN YU; Fiscal Year: 2002
    ..For each of these fluorous tags, a series of homologs with variable number of fluorines will be synthesized for the use in fluorous mixture synthesis. ..
  37. SYNTHESIS OF FUSED HETEROCYCLIC COMPOUNDS
    Albert Padwa; Fiscal Year: 2002
    ..The generation of biologically active compounds by new synthetic methods remains an important part of both health related and chemical research. ..
  38. Force Field Development for Protein Absorption Modeling
    Robert Latour; Fiscal Year: 2009
    ....
  39. RADICAL REACTIONS FOR NATURAL PRODUCTS
    DENNIS CURRAN; Fiscal Year: 2002
    ....
  40. DEVELOPMENT OF LIGAND ASSISTED ASYMMETRIC SYNTHESES
    Arun Ghosh; Fiscal Year: 2001
    ..Besides the broad range of scope and generality, this line of research will provide excellent opportunities to teach and train graduate and undergraduate students in the laboratory. ..
  41. Mechanistic Studies of Lipoic Acid Synthase
    Squire J Booker; Fiscal Year: 2010
    ..There is significant evidence that lipoic acid can be endogenously synthesized in mammalian cells, and that the inhibition of this pathway compromises cellular function and leads to death. ..
  42. Multivalency: Mechanisms and Applications
    George M Whitesides; Fiscal Year: 2010
    ....
  43. DESIGN AND SYNTHESIS OF NONPEPTIDE PROTEASE INHIBITORS
    Arun K Ghosh; Fiscal Year: 2010
    ..This research integrates organic synthesis, protein-ligand x-ray crystallography, molecular modeling and in-depth virus and cell-biological studies to design the next generation of HIV-1 protease inhibitors. ..
  44. Capillary Electrophoresis and Protein Biophysics
    George M Whitesides; Fiscal Year: 2010
    ....
  45. Epothilone Analogs by Partial Chemical Synthesis
    David Myles; Fiscal Year: 2002
    ..The proposed epothilone analogs with increased solubility will have a potentially competitive advantage for a $2 billion per year market for the treatment of breast, lung and ovarian cancers. ..
  46. Study of a New Class of Chiral Nucleophilic Catalysts
    VLADIMIR BIRMAN; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  47. ADRIAMYCIN-INDUCED MITOCHONDRIAL CARDIOMYOPATHY
    Kendall Wallace; Fiscal Year: 2004
    ....
  48. FLUOROUS METHODS FOR TRADITIONAL AND PARALLEL SYNTHESIS
    DENNIS CURRAN; Fiscal Year: 2003
    ..In short, the work will help to move the very young field of fluorous chemistry from infancy into childhood. ..
  49. Efficient synthesis of discodermolide
    Gary Ashley; Fiscal Year: 2005
    ..abstract_text> ..
  50. Tools To Study Cell Motility and Ion Channels
    George Whitesides; Fiscal Year: 2006
    ..The work spans biology, microfabrication, and biophysics, and an important product of the research will be students broadly trained in biological and physical sciences. ..
  51. Characterization of Vesicular Monoamine Transporters
    ARNOLD RUOHO; Fiscal Year: 2006
    ....
  52. Development of Etched Modified Capillaries
    JOSEPH PESEK; Fiscal Year: 2002
    ..Microsolv Corporation will undertake a marketing plan to distribute the products for use by companies working in the targeted application areas. ..
  53. NRTI-induced Mitochondrial Cardiomyopathy
    Kendall Wallace; Fiscal Year: 2006
    ..abstract_text> ..
  54. Protein Identification by Nanogap Capacitor Arrays
    Gabor Somorjai; Fiscal Year: 2006
    ..abstract_text> ..
  55. Sigma Receptor Structure /Function /K+ Channel Modulation
    ARNOLD RUOHO; Fiscal Year: 2007
    ..4 potassium channels and other protein partners. These experiments will be performed through the combined use of photoactivatable molecules, electrophysiology, and recombinant and fusion proteins. ..
  56. Open Tubular Capillary Electrochromatography/Mass Spectroscopy
    JOSEPH PESEK; Fiscal Year: 2007
    ..This project focuses on providing a means for the analysis of complex samples found in clinical, biological and pharmaceutical applications. [unreadable] [unreadable] [unreadable]..
  57. Purchase of a 600 MHz NMR Spectrometer with Cryoprobe
    DENNIS CURRAN; Fiscal Year: 2007
    ..This research often requires sophisticated NMR experiments on small samples, and the requested 600 MHz spectrometer will greatly expedite ongoing and planned work. [unreadable] [unreadable] [unreadable]..
  58. TUMOR REMISSION--TAXOL AND CLOSE ANALOGS VIA SYNTHESIS
    LEO PAQUETTE; Fiscal Year: 2003
    ..These include, but are not limited to, the 1-deoxy, D-homo-, 2-desmethyl, and 12-methylene derivatives, in addition to the D-ring invertomer and the C-nor isomer. ..
  59. Fluorous Quantitative Proteomics
    MARVIN YU; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  60. Microbial metabolism of aliphatic alkenes & epoxides
    SCOTT ENSIGN; Fiscal Year: 2008
    ..We intend to further our work on the central roles of carboxylation and novel cofactors/enzymes in bacterial hydrocarbon/epoxide/ketone metabolism by pursuing the biochemical, structural, and genetic characterization of these processes. ..
  61. CHEMICAL CONTROL OF SOCIAL BEHAVIOR
    Michael Greene; Fiscal Year: 2003
    ..This purpose of this research is to provide data that will add to understanding of the basic rules operating behind complex biological systems. ..