ethylene oxide

Summary

Summary: A colorless and flammable gas at room temperature and pressure. Ethylene oxide is a bactericidal, fungicidal, and sporicidal disinfectant. It is effective against most micro-organisms, including viruses. It is used as a fumigant for foodstuffs and textiles and as an agent for the gaseous sterilization of heat-labile pharmaceutical and surgical materials. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p794)

Top Publications

  1. ncbi Effects of different sterilization methods on the morphology, mechanical properties, and cytotoxicity of chitosan membranes used as wound dressings
    Paula Rulf Marreco
    Department of Biotechnological Processes, School of Chemical Engineering, PO Box 6066, State University of Campinas, Sao Paulo, 13081 970, Brazil
    J Biomed Mater Res B Appl Biomater 71:268-77. 2004
  2. ncbi Enhanced retention of polymer physical characteristics and mechanical strength of 70:30 poly(L-lactide-co-D,L-lactide) after ethylene oxide sterilization
    Anastasia J McManus
    MacroPore Biosurgery, a Cytori Therapeutics Company, 3020 Callan Road, San Diego, California 92121, USA
    J Biomed Mater Res B Appl Biomater 82:325-33. 2007
  3. ncbi OSHA compliance: issues ethylene oxide in a commercial sterilization operation
    George Daniel
    US Department of Labor, Occupational Safety and Health Administration, St Louis Area Office, St Louis, Missouri, USA
    J Occup Environ Hyg 1:D121-5. 2004
  4. ncbi Ethylene oxide sterilization of medical devices: a review
    Gisela C C Mendes
    Universidade Catolica Portuguesa, Escola Superior de Biotecnologia, Porto, Portugal
    Am J Infect Control 35:574-81. 2007
  5. ncbi Analysis of hemoglobin adducts from acrylamide, glycidamide, and ethylene oxide in paired mother/cord blood samples from Denmark
    Hans von Stedingk
    Department of Materials and Environmental Chemistry, Environmental Chemistry Unit, Arrhenius Laboratory, Stockholm University, SE 106 91 Stockholm, Sweden
    Chem Res Toxicol 24:1957-65. 2011
  6. ncbi Frequent p53 and H-ras mutations in benzene- and ethylene oxide-induced mammary gland carcinomas from B6C3F1 mice
    Christopher D Houle
    Laboratory of Experimental Pathology, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 34:752-62. 2006
  7. ncbi Effect of ethylene oxide sterilization on enamel and dentin demineralization in vitro
    Renske Z Thomas
    Department of Dentistry and Dental Hygiene, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    J Dent 35:547-51. 2007
  8. ncbi Hemoglobin adducts of ethylene oxide, propylene oxide, acrylonitrile and acrylamide-biomarkers in occupational and environmental medicine
    Thomas Schettgen
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich Alexander University of Erlangen Nurnberg, Schillerstrasse 25 29, D 91054 Erlangen, Germany
    Toxicol Lett 134:65-70. 2002
  9. pmc Ethylene oxide and cancer
    O Axelson
    Occup Environ Med 61:1. 2004
  10. ncbi Formation of DNA adducts and induction of mutagenic effects in rats following 4 weeks inhalation exposure to ethylene oxide as a basis for cancer risk assessment
    N J van Sittert
    Department of Molecular Toxicology, Shell International Chemicals, Amsterdam, Netherlands
    Mutat Res 447:27-48. 2000

Detail Information

Publications250 found, 100 shown here

  1. ncbi Effects of different sterilization methods on the morphology, mechanical properties, and cytotoxicity of chitosan membranes used as wound dressings
    Paula Rulf Marreco
    Department of Biotechnological Processes, School of Chemical Engineering, PO Box 6066, State University of Campinas, Sao Paulo, 13081 970, Brazil
    J Biomed Mater Res B Appl Biomater 71:268-77. 2004
    ..work was to compare the effects induced by two different sterilization methods (exposure to gamma radiation or ethylene oxide) and an antiseptic technique (immersion in 70% ethanol aqueous solution) on the morphology, tensile strength, ..
  2. ncbi Enhanced retention of polymer physical characteristics and mechanical strength of 70:30 poly(L-lactide-co-D,L-lactide) after ethylene oxide sterilization
    Anastasia J McManus
    MacroPore Biosurgery, a Cytori Therapeutics Company, 3020 Callan Road, San Diego, California 92121, USA
    J Biomed Mater Res B Appl Biomater 82:325-33. 2007
    This study examined the effect of ethylene oxide (EtO) and electron beam (e-beam) irradiation on the properties of 70:30 poly(L-lactide-co-D,L-lactide)...
  3. ncbi OSHA compliance: issues ethylene oxide in a commercial sterilization operation
    George Daniel
    US Department of Labor, Occupational Safety and Health Administration, St Louis Area Office, St Louis, Missouri, USA
    J Occup Environ Hyg 1:D121-5. 2004
  4. ncbi Ethylene oxide sterilization of medical devices: a review
    Gisela C C Mendes
    Universidade Catolica Portuguesa, Escola Superior de Biotecnologia, Porto, Portugal
    Am J Infect Control 35:574-81. 2007
    b>Ethylene oxide (EO) is a well-known sterilizing agent. However, only recently has its use significantly emerged, based on its range of applications in the field of new medical device development and sterilization...
  5. ncbi Analysis of hemoglobin adducts from acrylamide, glycidamide, and ethylene oxide in paired mother/cord blood samples from Denmark
    Hans von Stedingk
    Department of Materials and Environmental Chemistry, Environmental Chemistry Unit, Arrhenius Laboratory, Stockholm University, SE 106 91 Stockholm, Sweden
    Chem Res Toxicol 24:1957-65. 2011
    ..Acrylamide, glycidamide, and ethylene oxide are electrophiles and form adducts with hemoglobin (Hb), which could be used for in vivo dose measurement...
  6. ncbi Frequent p53 and H-ras mutations in benzene- and ethylene oxide-induced mammary gland carcinomas from B6C3F1 mice
    Christopher D Houle
    Laboratory of Experimental Pathology, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 34:752-62. 2006
    Benzene and ethylene oxide are multisite carcinogens in rodents and classified as human carcinogens by the National Toxicology Program. In 2-year mouse studies, both chemicals induced mammary carcinomas...
  7. ncbi Effect of ethylene oxide sterilization on enamel and dentin demineralization in vitro
    Renske Z Thomas
    Department of Dentistry and Dental Hygiene, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    J Dent 35:547-51. 2007
    ..The aim of this study was to assess the effect of sterilising sound human enamel and dentin with ethylene oxide on lesion depth and mineral loss before and after in vitro demineralization...
  8. ncbi Hemoglobin adducts of ethylene oxide, propylene oxide, acrylonitrile and acrylamide-biomarkers in occupational and environmental medicine
    Thomas Schettgen
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich Alexander University of Erlangen Nurnberg, Schillerstrasse 25 29, D 91054 Erlangen, Germany
    Toxicol Lett 134:65-70. 2002
    In a chemical plant, ethylene oxide (EO) and propylene oxide (PO) were used for the production of surfactants for the textile industry...
  9. pmc Ethylene oxide and cancer
    O Axelson
    Occup Environ Med 61:1. 2004
  10. ncbi Formation of DNA adducts and induction of mutagenic effects in rats following 4 weeks inhalation exposure to ethylene oxide as a basis for cancer risk assessment
    N J van Sittert
    Department of Molecular Toxicology, Shell International Chemicals, Amsterdam, Netherlands
    Mutat Res 447:27-48. 2000
    b>Ethylene oxide (EO) is mutagenic in various in vitro and in vivo test systems and carcinogenic in rodents. EO forms different adducts upon reaction with DNA, N7-(2-hydroxyethyl)guanine (N7-HEG) being the main adduct...
  11. ncbi Dose-response relationships for N7-(2-hydroxyethyl)guanine induced by low-dose [14C]ethylene oxide: evidence for a novel mechanism of endogenous adduct formation
    Debbie A Marsden
    Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, United Kingdom
    Cancer Res 69:3052-9. 2009
    b>Ethylene oxide (EO) is widely used in the chemical industry and is also formed in humans through the metabolic oxidation of ethylene, generated during physiologic processes...
  12. ncbi Carcinogenicity of 1,3-butadiene, ethylene oxide, vinyl chloride, vinyl fluoride, and vinyl bromide
    Yann Grosse
    Lancet Oncol 8:679-80. 2007
  13. ncbi Determination of endogenous and exogenously derived N7-(2-hydroxyethyl)guanine adducts in ethylene oxide-treated rats
    Debbie A Marsden
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, The Biocentre, University of Leicester, Leicester, LE1 7RH, United Kingdom
    Chem Res Toxicol 20:290-9. 2007
    b>Ethylene oxide (EO) is one of the most widely used intermediates in the chemical industry. It is also formed endogenously as a result of cytochrome P450-mediated metabolism of ethylene, which is ubiquitous in the environment...
  14. ncbi Influence of polymorphisms of the human glutathione transferases and cytochrome P450 2E1 enzyme on the metabolism and toxicity of ethylene oxide and acrylonitrile
    R Thier
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Ardeystr 67, D 44139 Dortmund, Germany
    Mutat Res 482:41-6. 2001
    ..The study also confirmed the impact of GSTT1 polymorphism on background N-(hydroxyethyl)-valine adduct levels in haemoglobin which are caused by endogenous ethylene oxide.
  15. ncbi Comparative evaluation of the sporicidal activity of new low-temperature sterilization technologies: ethylene oxide, 2 plasma sterilization systems, and liquid peracetic acid
    W A Rutala
    Division of Infectious Diseases, University of North Carolina, Chapel Hill 27599 7030, USA
    Am J Infect Control 26:393-8. 1998
    ..This study was undertaken to evaluate the efficacy of 4 new low-temperature sterilization technologies: ethylene oxide with hydrochlorofluorocarbons, a liquid peracetic acid immersion system (Steris System 1 Processor), and 2 ..
  16. pmc In vivo oxidation and surface damage in retrieved ethylene oxide-sterilized total knee arthroplasties
    Daniel MacDonald
    Implant Research Center, School of Biomedical Engineering, Science, and Health Systems, Drexel University, 3401 Market Street, Suite 300, Philadelphia, PA 19104, USA
    Clin Orthop Relat Res 470:1826-33. 2012
    Gas sterilization (eg, ethylene oxide [EtO] and gas plasma) was introduced for polyethylene to reduce oxidation due to free radicals occurring during radiation sterilization...
  17. pmc Kinetics of ethylene and ethylene oxide in subcellular fractions of lungs and livers of male B6C3F1 mice and male fischer 344 rats and of human livers
    Qiang Li
    Institute of Toxicology, German Research Center for Environmental Health, Helmholtz Zentrum Munchen, D 85764 Neuherberg, Germany
    Toxicol Sci 123:384-98. 2011
    Ethylene (ET) is metabolized in mammals to the carcinogenic ethylene oxide (EO). Although both gases are of high industrial relevance, only limited data exist on the toxicokinetics of ET in mice and of EO in humans...
  18. ncbi Validation of a dual cycle ethylene oxide treatment technique to remove DNA from consumables used in forensic laboratories
    Emily Archer
    Research and Development, Forensic Science Service Ltd 2960 Trident Court Solihull Parkway, Birmingham Business Park, Birmingham, United Kingdom
    Forensic Sci Int Genet 4:239-43. 2010
    Validation of a dual cycle ethylene oxide (EO) approach to removing DNA contamination from consumables has been undertaken...
  19. ncbi Reproductive and developmental risks from ethylene oxide: a probabilistic characterization of possible regulatory thresholds
    J S Evans
    Harvard School of Public Health, Boston, MA, USA
    Risk Anal 21:697-717. 2001
    b>Ethylene oxide is a gas produced in large quantities in the United States that is used primarily as a chemical intermediate in the production of ethylene glycol, propylene glycol, non-ionic surfactants, ethanolamines, glycol ethers, and ..
  20. pmc Reciprocal translocations in somatic and germ cells of mice chronically exposed by inhalation to ethylene oxide: implications for risk assessment
    E Maria Donner
    The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    Mutagenesis 25:49-55. 2010
    Groups of male B6C3F1 mice were exposed by inhalation to 0, 25, 50, 100 or 200 p.p.m. ethylene oxide (EO) for up to 48 weeks (6 hours/day, 5 days/week)...
  21. ncbi Increased genotoxic susceptibility of breast epithelial cells to ethylene oxide
    Balázs Adám
    Department of Preventive Medicine, School of Public Health, Medical and Health Science Center, University of Debrecen, P O Box 9, H 4012, Debrecen, Hungary
    Mutat Res 585:120-6. 2005
    This study was carried out with the aim of elucidating the organ-specific effects of ethylene oxide in comparison with the sensitivity of cells from different tissues...
  22. ncbi An evaluation of the capacity of differently prepared demineralised bone matrices (DBM) and toxic residuals of ethylene oxide (EtOx) to provoke an inflammatory response in vitro
    R J Lomas
    Yorkshire Regional Tissue Bank, National Blood Service, Pinderfields General Hospital, Wakefield, UK
    Biomaterials 22:913-21. 2001
    ..There is a long history of controversy relating to the suitability of ethylene oxide gas (EtOx) as a terminal sterilisation agent for this graft, relating to its effects on the clinical ..
  23. ncbi Mechanical strength of cortical allografts with gamma radiation versus ethylene oxide sterilization
    Zongke Zhou
    Department of Orthopaedic Surgery, West China Hospital of Sichuan University, Chengdu, China
    Acta Orthop Belg 77:670-5. 2011
    We investigated the effects of gamma irradiation versus ethylene oxide (ETO) sterilization on the mechanical strength of cortical bone grafts. Tibias were collected from cadavers of mature goats...
  24. ncbi Modulation of lymphatic distribution of subcutaneously injected poloxamer 407-coated nanospheres: the effect of the ethylene oxide chain configuration
    S M Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton BN2 4GJ, UK
    FEBS Lett 540:241-4. 2003
    ..injected poloxamer 407-coated nanospheres (45 nm in diameter) is controlled by surface configuration of the ethylene oxide (EO) segments of the adsorbed copolymer...
  25. ncbi Increase in early polyethylene wear after sterilization with ethylene oxide: radiostereometric analyses of 201 total hips
    Georgios Digas
    Department of Orthopaedics, Institute of Surgical Science, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
    Acta Orthop Scand 74:531-41. 2003
    ..Moreover, 37 cemented cups were sterilized with ethylene oxide (Reflection all-poly) and 69 porous-coated cups had liners sterilized in ethylene oxide (Reflection)...
  26. ncbi Relevance of the deletion polymorphisms of the glutathione S-transferases GSTT1 and GSTM1 in pharmacology and toxicology
    H M Bolt
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany
    Curr Drug Metab 7:613-28. 2006
    ..This appears relevant in industrial toxicology and in drug metabolism...
  27. ncbi Effect of ethylene oxide and propylene oxide block copolymers on the permeability of bilayer lipid membranes to small solutes including doxorubicin
    V Y Erukova
    A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow 119899, Russia
    Biochim Biophys Acta 1468:73-86. 2000
    The effects of ethylene oxide and propylene oxide block copolymers (pluronics) on the permeability of several weak acids and bases through bilayer lipid membranes have been studied by the methods of monitoring (1) pH shifts near planar ..
  28. ncbi Release of anti-restenosis drugs from poly(ethylene oxide)-poly(DL-lactic-co-glycolic acid) nanoparticles
    Miechel L T Zweers
    Department of Polymer Chemistry and Biomaterials, Institute for Biomedical Technology, Faculty of Science and Technology, University of Twente, PO Box 217, 7500 AE Enschede, The Netherlands
    J Control Release 114:317-24. 2006
    Dexamethasone- or rapamycin-loaded nanoparticles based on poly(ethylene oxide) and poly(dl-lactic-co-glycolic acid) block copolymers (PEO-PLGA) were prepared without additional stabilizer using the salting-out method...
  29. ncbi Hyaluronic acid hydrogel in the treatment of osteoarthritis
    R Barbucci
    Department of Chemical and Biosystem Sciences and Technology, CRISMA, University of Siena, Italy
    Biomaterials 23:4503-13. 2002
    ..Liophilised Hyal 50% samples were sterilised by steam, Ethylene Oxide (EtO) and gamma-rays...
  30. ncbi Sustained and extended release with structural and activity recovery of lysozyme from complexes with sodium (sulfamate carboxylate) isoprene/ethylene oxide block copolymer
    Gao Gao
    Key Laboratory of Molecular Engineering of Polymers, and Department of Macromolecular Science, Fudan University, Shanghai 200433, China
    Macromol Biosci 10:139-46. 2010
    The complexation of lysozyme and sodium (sulfamate carboxylate) isoprene/ethylene oxide (SCIEO) at pH = 7.4 and the release of lysozyme from the complexes in the presence of NaCl were investigated...
  31. pmc Mortality analyses in a cohort of 18 235 ethylene oxide exposed workers: follow up extended from 1987 to 1998
    K Steenland
    Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    Occup Environ Med 61:2-7. 2004
    To extend mortality follow up from 1987 to 1998 for cohort of 18 235 men and women exposed to ethylene oxide.
  32. ncbi DNA adducts in granulocytes of hospital workers exposed to ethylene oxide
    Lee C Yong
    Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, CDC, Cincinnati, Ohio 45226, USA
    Am J Ind Med 50:293-302. 2007
    b>Ethylene oxide (EtO), an important industrial chemical intermediate and sterilant, is classified as a human carcinogen...
  33. ncbi Detection of viable fungal spores contaminant on documents and rapid control of the effectiveness of an ethylene oxide disinfection using ATP assay
    Malalanirina S Rakotonirainy
    Centre de Recherches sur la Conservation des Documents Graphiques CRCDG, MNHN MCC CNRS UMR 8573, 36 rue Geoffroy Saint Hilaire, 75005 Paris, France
    Luminescence 18:113-21. 2003
    ..The validity of the procedure was also tested on spores killed by steam and on spores treated with ethylene oxide. We showed that EC determination could be used for a rapid control of the effectiveness of a disinfection ..
  34. ncbi DNA adducts: effects of low exposure to ethylene oxide, vinyl chloride and butadiene
    J A Swenberg
    Department of Environmental Sciences and Engineering, University of North Carolina, Campus Box 7400, Chapel Hill, NC 27599, USA
    Mutat Res 464:77-86. 2000
    ..formed DNA adducts may be identical to those formed by chemicals, as in the case of vinyl chloride and ethylene oxide, or they may be those associated with oxidative stress...
  35. ncbi The effect of ethylene exposure on ethylene oxide in blood and on hepatic cytochrome p450 in Fischer rats
    Timothy R Fennell
    CIIT Centers for Health Research, Research Triangle Park, NC 27709, USA
    Toxicol Sci 81:7-13. 2004
    Ethylene (74-85-1) is an important petrochemical and is produced endogenously. It is metabolized to ethylene oxide (EO) by cytochrome P450...
  36. ncbi Formation of tetra(ethylene oxide) terminated Si-C linked monolayers and their derivatization with glycine: an example of a generic strategy for the immobilization of biomolecules on silicon
    Till Böcking
    School of Physics and School of Chemistry, University of New South Wales, Sydney, Australia
    Langmuir 21:10522-9. 2005
    Surface modification with oligo(ethylene oxide) functionalized monolayers terminated with reactive headgroups constitutes a powerful strategy to provide specific coupling of biomolecules with simultaneous protection from nonspecific ..
  37. ncbi Dose-dependent influence of genetic polymorphisms on DNA damage induced by styrene oxide, ethylene oxide and gamma-radiation
    Lode Godderis
    Katholieke Universiteit Leuven K U L, Laboratorium Voor Arbeidshygiëne en Toxicologie, Kapucijnenvoer 35 6, 3000 Leuven, Belgium
    Toxicology 219:220-9. 2006
    Styrene oxide (SO), ethylene oxide (EO) and gamma-radiation (G) are agents with a well-described metabolism and genotoxicity. EPHX1 and GSTs play an important role in the detoxification of electrophiles and oxidative stress...
  38. ncbi Ethylene oxide gas sterilization: a simple technique for storing explanted skull bone. Technical note
    David H Jho
    Neurosurgical Service, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Neurosurg 107:440-5. 2007
    The authors evaluated the effectiveness of a simple technique using ethylene oxide (EtO) gas sterilization and room temperature storage of autologous bone grafts for reconstructive cranioplasty following decompressive craniectomy...
  39. ncbi Effect of surface roughness and sterilization on bacterial adherence to ultra-high molecular weight polyethylene
    T J Kinnari
    Department of Clinical Microbiology, Fundacion Jimenez Diaz, Madrid, Spain
    Clin Microbiol Infect 16:1036-41. 2010
    Sterilization with ethylene oxide (EO) and gas plasma (GP) are well-known methods applied to ultra-high molecular weight polyethylene (UHMWPE) surfaces in the belief that they prevent major material changes caused by gamma irradiation...
  40. ncbi Ethylene oxide and breast cancer incidence in a cohort study of 7576 women (United States)
    Kyle Steenland
    National Institute for Occupational Safety and Health NIOSH, Cincinnati, Ohio 30322, USA
    Cancer Causes Control 14:531-9. 2003
    b>Ethylene oxide (ETO) is a sterilant gas considered to be a human carcinogen, due primarily to excess hematopoietic cancer in exposed cohorts...
  41. ncbi Ethylene oxide sterilization in the medical-supply manufacturing industry: assessment and control of worker exposure
    Yeh Chung Chien
    Department of Industrial Safety and Health, Hungkuang University, Shalu, Taiwan
    J Biomed Mater Res B Appl Biomater 83:527-37. 2007
    ..and Health started an on-site consulting program for the medical supplies manufacturing industry, which use ethylene oxide (EO) as a sterilant, with the goal of enhancing occupational hygiene practices and controlling EO-related ..
  42. ncbi Comparative analysis of urinary N7-(2-hydroxyethyl)guanine for ethylene oxide- and non-exposed workers
    Chih Chun Jean Huang
    Department of Food Science, National Pingtung University of Science and Technology, 1 Shuefu Rd, Neipu, Pingtung 91201, Taiwan
    Toxicol Lett 202:237-43. 2011
    b>Ethylene oxide (EO), a direct alkylating agent and a carcinogen, can attack the nucleophilic sites of DNA bases to form a variety of DNA adducts...
  43. pmc Mortality of workers exposed to ethylene oxide: extended follow up of a British cohort
    D Coggon
    MRC Environmental Epidemiology Unit, University of Southampton, UK
    Occup Environ Med 61:358-62. 2004
    To obtain further information about the risks of cancer associated with occupational exposure to ethylene oxide
  44. ncbi Life-table calculations of excess risk for incidence versus mortality: ethylene oxide case study
    Robert L Sielken
    Sielken and Associates Consulting Inc, 3833 South Texas Avenue, Suite 230, Bryan, TX 77802, USA
    Regul Toxicol Pharmacol 55:82-9. 2009
    In US EPA's evaluation of ethylene oxide (EO) in 2006, the calculation of the excess risk of lymphohematopoietic (LH) cancer incidence was flawed...
  45. ncbi Comparative sterilization effectiveness of plasma in O2-H2O2 mixtures and ethylene oxide treatment
    J M F Silva
    Laboratory of Medicine and Cosmetic Quality Control, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    PDA J Pharm Sci Technol 61:204-10. 2007
    ..the influence of variable parameters of plasma sterilization and compared its effectiveness with that of ethylene oxide using a reactive ion etching plasma reactor at 13.56 MHz...
  46. ncbi Mortality study update of ethylene oxide workers in chemical manufacturing: a 15 year update
    Gerard M H Swaen
    Department of Epidemiology, Health Services, The Dow Chemical Company, Midland, Mich, USA
    J Occup Environ Med 51:714-23. 2009
    To investigate the long-term mortality patterns of workers with past exposure to ethylene oxide (EO).
  47. ncbi A physiologically based pharmacokinetic model for ethylene oxide in mouse, rat, and human
    T R Fennell
    CIIT Centers for Health Research, Research Triangle Park, North Carolina, 27709, USA
    Toxicol Appl Pharmacol 173:161-75. 2001
    b>Ethylene oxide (EO) is widely used as a gaseous sterilant and industrial intermediate and is a direct-acting mutagen and carcinogen...
  48. ncbi Personal exposure level and environmental ethylene oxide gas concentration in sterilization facilities of hospitals in Japan
    Hajime Hori
    Departament of Environmental Management, School of Health Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan
    Appl Occup Environ Hyg 17:634-9. 2002
    Personal and environmental (stationary) ethylene oxide (EO) gas concentrations in gas sterilization facilities were measured at six workplaces in five hospitals...
  49. ncbi Size control of styrene oxide-ethylene oxide diblock copolymer aggregates with classical surfactants: DLS, TEM, and ITC study
    Emilio Castro
    Grupo de Sistemas Complejos, Laboratorio de Física de Coloides y Polímeros, Departamento de Fisica de la Materia Condensada, Facultad de Fisica, Universidad de Santiago de Compostela, Spain
    Biomacromolecules 6:1438-47. 2005
    ..From that point, important differences in the ITC plot for both surfactants are present. However, the ITC curve obtained after titration of a SOS solution in the copolymer solution is quite similar to that of its titration in water...
  50. ncbi Micellization and drug solubilization in aqueous solutions of a diblock copolymer of ethylene oxide and phenyl glycidyl ether
    Pablo Taboada
    Department of Physics of Condensed Matter, University of Santiago de Compostela, E 15706 Santiago de Compostela, Spain
    Langmuir 22:7465-70. 2006
    ..b>Ethylene oxide and phenyl glycidyl ether were sequentially polymerized to form the diblock copolymer G5E67 (G = phenyl ..
  51. ncbi Crystal structures of native and inactivated cis-3-chloroacrylic acid dehalogenase. Structural basis for substrate specificity and inactivation by (R)-oxirane-2-carboxylate
    René M de Jong
    Laboratory of Biophysical Chemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    J Biol Chem 282:2440-9. 2007
    ..The involvement of His-28 and Tyr-103' distinguishes the cis-CaaD mechanism from the otherwise parallel CaaD mechanism. The two mechanisms probably evolved independently as the result of an early gene duplication of a common ancestor...
  52. ncbi Oxidation in orthopaedic UHMWPE sterilized by gamma-radiation and ethylene oxide
    L Costa
    Dipartimento di Chimica Inorganica e Chimica Fisica dell Università di Torino, Italy
    Biomaterials 19:659-68. 1998
    Ten new polyethylene prosthetic components (PEs), ethylene oxide (EtO)- and gamma-sterilized, were studied by means of infrared (IR) analysis in order to evaluate oxidation...
  53. ncbi Block copolymers of ethylene oxide and phenyl glycidyl ether: micellization, gelation, and drug solubilization
    Pablo Taboada
    Department of Physics of Condensed Matter, University of Santiago de Compostela, E 15706 Santiago de Compostela, Spain
    Langmuir 21:5263-71. 2005
    Three triblock copolymers of ethylene oxide and phenyl glycidyl ether, type E(m)G(n)E(m), where G = OCH2CH(CH2OC6H5) and E = OCH2CH2, were synthesized and characterized by gel-permeation chromatography, matrix-assisted laser desorption ..
  54. ncbi Exposure to ethylene oxide in hospitals: biological monitoring and influence of glutathione S-transferase and epoxide hydrolase polymorphisms
    Vincent Haufroid
    Industrial Toxicology and Occupational Medicine Unit, Catholic University of Louvain, Brussels, Belgium
    Cancer Epidemiol Biomarkers Prev 16:796-802. 2007
    b>Ethylene oxide is considered as a human carcinogen. A biomarker of exposure would be a useful instrument to assess the risk in occupationally exposed workers...
  55. ncbi Stereospecific alkylation of cis-3-chloroacrylic acid dehalogenase by (R)-oxirane-2-carboxylate: analysis and mechanistic implications
    Gerrit J Poelarends
    Division of Medicinal Chemistry, College of Pharmacy, The University of Texas, Austin, Texas 78712 1074, USA
    Biochemistry 43:7187-96. 2004
    ..These findings set the stage for a crystallographic analysis of the inactived enzyme to delineate further the roles of active site residues in both the inactivation process and the catalytic mechanism...
  56. pmc Cancer incidence and mortality in Swedish sterilant workers exposed to ethylene oxide: updated cohort study findings 1972-2006
    Zoli Mikoczy
    Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, and Occupational and Environmental Medicine, Skane University Hospital, SE 221 85 Lund, Sweden
    Int J Environ Res Public Health 8:2009-19. 2011
    ..cancer incidence, mainly from lymphohaematopoietic tumours and breast cancer, and mortality were increased in a cohort of Swedish sterilant workers exposed to low levels of ethylene oxide (EtO), updated with 16 more years of follow up.
  57. ncbi Effects of ethylene oxide and ethylene inhalation on DNA adducts, apurinic/apyrimidinic sites and expression of base excision DNA repair genes in rat brain, spleen, and liver
    Ivan Rusyn
    Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    DNA Repair (Amst) 4:1099-110. 2005
    b>Ethylene oxide (EO) is an important industrial chemical that is classified as a known human carcinogen (IARC, Group 1)...
  58. ncbi Genotoxic effects of ethylene oxide, propylene oxide and epichlorohydrin in humans: update review (1990-2001)
    Ada Kolman
    Department of Molecular Biology and Functional Genomics, Stockholm University, SE 106 91, Stockholm, Sweden
    Mutat Res 512:173-94. 2002
    b>Ethylene oxide (EtO), propylene oxide (PO) and epichlorohydrin (ECH) are important industrial chemicals widely used as intermediates for various synthetic products. EtO and PO are also environmental pollutants...
  59. ncbi Sterilization and strength of 70/30 polylactide cages: e-beam versus ethylene oxide
    Theo H Smit
    Department of Physics and Medical Technology, VU University Medical Center, Amsterdam, The Netherlands
    Spine (Phila Pa 1976) 32:742-7. 2007
    ..In vitro and in vivo studies on the degradation of 70/30 poly(L,DL-lactide) (PLDLLA) cages...
  60. ncbi Bromoethane, chloroethane and ethylene oxide induced uterine neoplasms in B6C3F1 mice from 2-year NTP inhalation bioassays: pathology and incidence data revisited
    Catherine A Picut
    Biotechnics, Inc, Hillsborough, North Carolina, USA
    Exp Toxicol Pathol 55:1-9. 2003
    Chloroethane, bromoethane and ethylene oxide represent a unique set of chemicals that induce endometrial neoplasms in the uterus of B6C3F1 mice following an inhalation route of exposure...
  61. ncbi Novel hydrogel membrane based on copoly(hydroxyethyl methacrylate/p-vinylbenzyl-poly(ethylene oxide)) for biomedical applications: properties and drug release characteristics
    M Yakup Arica
    Biochemical Processing and Biomaterial Research Laboratory, Faculty of Science, Kirikkale University, 71450 Yahşihan Kirikkale, Turkey
    Macromol Biosci 5:983-92. 2005
    ..in the membrane form using 2-hydroxyethyl methacrylate monomer (HEMA) and a macromonomer p-vinylbenzyl-poly(ethylene oxide) (V-PEO) via photoinitiated polymerization...
  62. ncbi A radiological evaluation of allografts (ethylene oxide sterilized cadaver bone) and autografts in anterior cervical fusion
    J K B C Parthiban
    Department of Neurosurgery, L T M Medical College and L T M G Hospital, Sion, Mumbai, 400103, India
    Neurol India 50:17-22. 2002
    Serial roentgenograms of 40 patients who had 70 cervical intervertebral spaces grafted with ethylene oxide sterilized cadaver bone and 28 patients who received 44 iliac crest auto grafts for anterior cervical spine fusion, were studied...
  63. ncbi Biomonitoring of exposure to ethylene oxide and propylene oxide by determination of hemoglobin adducts: correlations between airborne exposure and adduct levels
    P J Boogaard
    Department of Molecular Toxicology, Shell Research and Technology Center, Amsterdam Shell International Chemicals B V, The Netherlands
    Int Arch Occup Environ Health 72:142-50. 1999
    b>Ethylene oxide (EO) and propylene oxide (PO) are important industrial chemicals. Exposure to these directly acting mutagens may be monitored by determination of their adducts to hemoglobin (Hb)...
  64. ncbi Biomarkers of exposure and effect as indicators of potential carcinogenic risk arising from in vivo metabolism of ethylene to ethylene oxide
    V E Walker
    Department of Pathology and Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7525, USA
    Carcinogenesis 21:1661-9. 2000
    ..potential use of several biomarkers as quantitative indicators of the in vivo conversion of ethylene (ET) to ethylene oxide (EO); (ii) to produce molecular dosimetry data that might improve assessment of human risk from exogenous ET ..
  65. ncbi Occupational exposure to ethylene oxide during pregnancy and association with adverse reproductive outcomes
    Daniela F Gresie-Brusin
    School of Public Health, University of the Witwatersrand, P O Box 2900, Johannesburg, 2132, South Africa
    Int Arch Occup Environ Health 80:559-65. 2007
    To investigate the association between exposure to ethylene oxide during pregnancy and adverse reproductive outcomes.
  66. ncbi Hemoglobin adducts from acrylonitrile and ethylene oxide in cigarette smokers: effects of glutathione S-transferase T1-null and M1-null genotypes
    T R Fennell
    Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina 27709, USA
    Cancer Epidemiol Biomarkers Prev 9:705-12. 2000
    ..It is carcinogenic in rats and is found in cigarette smoke. Ethylene oxide (EO) is a metabolite of ethylene, also found in cigarette smoke, and is carcinogenic in rodents...
  67. ncbi Preparation and characterization of nanoaggregates of poly(ethylene oxide)-b-polymethacrylate and poly-L-lysine
    Yuan Li
    Department of Chemistry, Faculty of Science and Engineering, Saga University, 1 Honjo Machi, Saga 840 8502, Japan
    J Colloid Interface Sci 264:561-4. 2003
    Poly(ethylene oxide)-b-polymethacrylate (PEO-b-PMA), one of the double-hydrophilic block copolymers, has proved to the form nanoaggregates with poly-L-lysine (PLS)...
  68. ncbi In vivo mutagenicity of ethylene oxide at the hprt locus in T-lymphocytes of B6C3F1 lacI transgenic mice following inhalation exposure
    V E Walker
    Department of Pathology, University of North Carolina at Chapel Hill, 27599 7525, USA
    Mutat Res 392:211-22. 1997
    b>Ethylene oxide (EO) is a direct-acting alkylating agent with the potential to induce cytogenetic alterations, mutations, and cancer...
  69. ncbi Factors affecting tailing in ethylene oxide sterilization part 1: When tailing is an artifact... and scientific deficiencies in ISO 11135 and EN 550
    Gregg A Mosley
    Biotest Laboratories, Inc, Minneapolis, MN, USA
    PDA J Pharm Sci Technol 58:81-95. 2004
    ..Application of these methods will allow more accurate calculations of process lethality that are supported by biological data and appropriate mathematical analyses...
  70. ncbi Effects of sterilisation method on surface topography and in-vitro cell behaviour of electrostatically spun scaffolds
    Kirstie D Andrews
    UK Centre for Tissue Engineering, Division of Clinical Engineering, Duncan Building, Daulby Street, University of Liverpool, Liverpool, L69 3GA, UK
    Biomaterials 28:1014-26. 2007
    ..Scaffolds made from Tecoflex SG-80A polyurethane were sterilised using ethylene oxide and UV-ozone...
  71. ncbi Effectiveness of microwave irradiation on the disinfection of complete dentures
    Mariana Montenegro Silva
    Department of Dental Materials and Prosthodontics, Araraquara Dental School, Sao Paulo State University, Brazil
    Int J Prosthodont 19:288-93. 2006
    ..The purpose of this study was to evaluate the effectiveness of microwave irradiation on the disinfection of simulated complete dentures...
  72. ncbi Effect of re-sterilization of surgical sutures by ethylene oxide
    Prem Anand Nagaraja
    Narayana Hrudayalaya, Bommasandra Industrial Area, Anekal Taluk, Bangalore, Karnataka, India
    ANZ J Surg 77:80-3. 2007
    ..These unused sutures with their foil packs still unopened are sometimes re-sterilized using ethylene oxide to allow for reuse...
  73. ncbi Safety evaluation of single-use medical devices after submission to simulated reutilization cycles
    Mônica Valero Da Silva
    Fundacao Universidade de Brasilia, Faculdade de Ciencias da Saude, Departamento de Farmacia, Campus Universitário Asa Norte, CEP 70910 900, Brazilia, DF, Brazil
    J AOAC Int 88:823-9. 2005
    ..cycles consisted of subsequent wash with enzymatic detergent followed by drying and sterilization with ethylene oxide-CFC (12 + 88), 600 mg/L at 55 degrees C, relative humidity 60%, for 3 h...
  74. pmc Effect of polyoxypropylene chain length on the critical micelle concentration of propylene oxide-ethylene oxide block copolymers
    Zhi Guo Zhang
    Department of Chemical Engineering, Zhejiang University, Hangzhou 310027, China
    J Zhejiang Univ Sci B 6:219-21. 2005
    ..The change in the work of cohesion per oxypropylene group when passing from molecular into micellar state, calculated from the Shinoda equation, was 0.43 kT for the studied compounds...
  75. ncbi Gamma irradiation and ethylene oxide in the sterilization of native reindeer bone morphogenetic protein extract
    T Pekkarinen
    Bone Transplantation Research Group, Department of Orthopaedic and Trauma Surgery, University of Oulu, P O Box 5000, FIN 90014 Oulu, Finland
    Scand J Surg 94:67-70. 2005
    ..We compared the effects of ethylene oxide and gamma irradiation in the sterilization of native reindeer BMP extract with regard to bone induction in the ..
  76. ncbi Low-shrinkage dental restorative composite: modeling viscoelastic behavior during setting
    Bibi S Dauvillier
    Department of Inorganic Chemistry and Catalysis, Debije Institute, Utrecht University, Sorbonnelaan 16, NL 3584 CA Utrecht, The Netherlands
    J Biomed Mater Res B Appl Biomater 73:129-39. 2005
    ..Evaluation tests of their potential as restorative material are required, to examine if the biocompatibility and mechanical properties after setting of oxirane composites are acceptable for dental use...
  77. ncbi Polycationic block copolymers of poly(ethylene oxide) and poly(propylene oxide) for cell transfection
    Lev Bromberg
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Bioconjug Chem 16:626-33. 2005
    ..poly(2-N-(dimethylaminoethyl) methacrylate) (pDMAEMA) and copolymers of poly(propylene oxide) (PPO) and poly(ethylene oxide) (PEO) has been developed...
  78. ncbi Damage of office supply, personal use items, and over-the-counter medical devices after sterilization by ethylene oxide gas, electron beam, and gamma radiation
    Anne D Lucas
    U S Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Silver Spring, MD, USA
    Biomed Instrum Technol 38:476-84. 2004
    ..The effects of three sterilization methods (i.e. ethylene oxide gas [EO], electron beam [e-beam] radiation, and gamma radiation) were evaluated for a variety of office supply ..
  79. ncbi Block lengths and block sequence of linear triblock and glycerol derivative diblock copolyethers by electrospray ionization--collision-induced dissociation mass spectrometry
    Peran Terrier
    Laboratoire Analyse et Modelisation pour la Biologie et l Environnement, Universite d Evry Val d Essonne, CNRS UMR 8587, Bat Maupertuis, Bd F Mitterrand, 91025 Evry Cedex, France
    Anal Chem 78:1801-6. 2006
    Chemical properties of ethylene oxide (EO) and propylene oxide (PO) block copolymers are strongly dependent on their sequence. Useful information about copolymer sequence can be obtained by tandem mass spectrometry (MS/MS)...
  80. ncbi Resterilization of instruments used in a hospital-based oral and maxillofacial surgery clinic
    Nicholas J V Hogg
    Department of Oral and Maxillofacial Sciences, Faculty of Dentistry, Dalhousie University, Halifax, Nova Scotia
    J Can Dent Assoc 71:179-82. 2005
    ..The purpose of this study was to investigate the rate of bacterial contamination of instruments resterilized for use in oral and maxillofacial procedures in a hospital-based clinic...
  81. ncbi A histological and immunohistochemical study of tissue reactions to solid poly(ortho ester) in rabbits
    M Ekholm
    Department of Oral and Maxillofacial Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Int J Oral Maxillofac Surg 35:631-5. 2006
    ..Resorption times and the effect of 2 different sterilization methods (gamma radiation and ethylene oxide) upon resorption were also evaluated...
  82. ncbi Electrospun three-dimensional hyaluronic acid nanofibrous scaffolds
    Yuan Ji
    Department of Materials Science and Engineering, SUNY at Stony Brook, Stony Brook, NY 11794 2275, USA
    Biomaterials 27:3782-92. 2006
    ..In order to facilitate the fiber formation during electrospinning, Poly (ethylene oxide) (PEO) was added into the aqueous solution of HA-DTPH at an optimal weight ratio of 1:1...
  83. ncbi Comparison of the effects of sterilisation techniques on subsequent DNA profiling
    Kirsty Shaw
    Department of Forensic Science and Drug Monitoring, King s College London, London, SE1 9NH, UK
    Int J Legal Med 122:29-33. 2008
    ..Four sterilisation techniques (UV, gamma and beta radiation and ethylene oxide treatment) were examined for their potential to degrade contaminating DNA to such an extent that subsequent ..
  84. ncbi Use of peracetic acid to sterilize human donor skin for production of acellular dermal matrices for clinical use
    Qizhi Huang
    Medical Cryobiology Unit, Department of Biology, The University of York, York, United Kingdom
    Wound Repair Regen 12:276-87. 2004
    ..In a comparison of gamma-irradiation, glycerol, and ethylene oxide, sterilization with ethylene oxide after treatment with glycerol provided the most satisfactory dermis in ..
  85. ncbi Sterlization techniques for the dental office
    Rodney M Stine
    Tex Dent J 121:240-2. 2004
  86. ncbi Purification of protein and recycling of polymers in a new aqueous two-phase system using two thermoseparating polymers
    J Persson
    Department of Biochemistry, Lund University, Sweden
    J Chromatogr A 864:31-48. 1999
    ..The polymers used in this work are EO50PO50, a random copolymer of 50% ethylene oxide (EO) and 50% propylene oxide (PO), and a hydrophobically modified random copolymer of EO and PO with aliphatic ..
  87. ncbi Round-robin evaluation of a solid-phase microextraction-gas chromatographic method for reliable determination of trace level ethylene oxide in sterilized medical devices
    Thomas Harper
    Sterile Process Technologies SPT, a Division of the Johnson and Johnson Corp, Route 1 and Commerce Blvd, North Brunswick, NJ 08902, USA
    Biomed Chromatogr 22:136-48. 2008
    Medical devices that are sterilized with ethylene oxide (EtO) retain small quantities of EtO residuals, which may cause negative systemic and local irritating effects, and must be accurately quantified to ensure non-toxicity...
  88. ncbi Effects of ethylene oxide and steam sterilization on dialysis-induced cytokine release by cuprophan membrane
    Filippo Aucella
    Department of Nephrology and Dialysis, Casa Sollievo della Sofferenza Hospital Istituto di Ricovero e Cura a Carattere Scientifico, San Giovanni Rotondo FG, Italy
    Artif Organs 26:543-5. 2002
    ..They were using a 1.3 m2 ethylene oxide (E3) or steam (E3S) sterilized Cuprophan membrane...
  89. ncbi [Influence of sterilization treatments on continuous carbon-fiber reinforced polyolefin composite]
    Shi bing Guan
    Department of Orthopedic Surgery, Second Affiliated Hospital of Shandong University, Jinan, China
    Zhonghua Yi Xue Za Zhi 87:2228-31. 2007
    ..To evaluate the influence of sterilization treatment on continuous carbon-fiber reinforced polyolefin composite (CFRP) so as to provide experimental reference for selection of sterilization method for CFRP...
  90. ncbi Absorbable sandwich-like membrane for retinal-sheet transplantation
    Ging Ho Hsiue
    Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan 30043, Republic of China
    J Biomed Mater Res 61:19-25. 2002
    ..Three sterilization methods were conducted, with hydrogen peroxide gas plasma (HPGP), ethylene oxide (EO), and gamma-ray irradiation (gamma). The results were compared with those of a control (no disinfection)...
  91. ncbi The effects of ethylene oxide and gas-plasma sterilization on failure strength and failure mode of pre-tied monofilament ligature loops
    Steven S Trostle
    Department of Surgical Sciences, University of Wisconsin, WI, USA
    Vet Surg 31:281-4. 2002
    To evaluate the effects of ethylene oxide and gas-plasma sterilization on the failure strength and failure mode of pre-tied monofilament ligature loops.
  92. ncbi Reprocessing of single-use endoscopic biopsy forceps and snares. One hospital's study
    D Hambrick
    Gastrointestinal Laboratory, Montclair Center for Digestive Diseases, Montclair Baptist Medical Center, 800 Montclair Road, Birmingham, AL 35213, USA
    Gastroenterol Nurs 24:112-5. 2001
    ..Reprocessing of the single-use devices tested did not result in endoscopic instruments that met acceptable standards for sterility at our institution...
  93. ncbi Safety of plasma-based sterilization: surface modifications of polymeric medical devices induced by Sterrad and Plazlyte processes
    S Lerouge
    Biomedical Engineering Institute, Ecole Polytechnique, Station Centre Ville, PO Box 6079, Montreal, Quebec H3C 3A7, Canada
    Biomed Mater Eng 12:3-13. 2002
    Plasma-based sterilization is a promising alternative to the use of pure ethylene oxide (EO), for low-temperature clinical sterilization of medical instruments and devices...
  94. ncbi Effects of the sterilisation method on the wear of UHMWPE acetabular cups tested in a hip joint simulator
    S Affatato
    Laboratorio di Tecnologia Medica, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 23:1439-46. 2002
    ..This study was performed to investigate the effects of the sterilisation method (gamma irradiation and ethylene oxide treatment) on the wear and on the changes in physical properties of polyethylene acetabular cups...
  95. ncbi In vivo change of elastic property in polyethylene acetabular components
    Atsushi Kusaba
    Institute of Joint Replacement and Rheumatology, Ebina General Hospital, Ebina, Kanagawa, Japan
    Mod Rheumatol 18:140-5. 2008
    ..Thirty-two cups were sterilized by gamma irradiation in air and 24 by ethylene oxide gas (EtO)...
  96. ncbi Effects of ethylene oxide gas sterilization on physical properties of poly(L-lactide)-poly(ethylene glycol)-poly(L-lactide) microspheres
    Y C Ah
    Department of Materials Science and Engineering, Kwangju Institute of Science and Technology, Korea
    J Biomater Sci Polym Ed 12:783-99. 2001
    The aggregation of poly(alpha-hydroxy acid) microspheres during ethylene oxide (EO) gas sterilization makes it difficult for the microspheres to be used in clinical applications...
  97. ncbi Assessment of parameters associated to the risk of PVC catheter reuse
    D L Granados
    National University of San Juan, Institute of Chemical Engineering, , San Juan, Argentina
    J Biomed Mater Res 58:505-10. 2001
    ..b>Ethylene oxide hospital-reprocessed central venous catheter samples were obtained from the stock of a health-care institution...
  98. ncbi Decomposition of ethylene oxide in the RF plasma environment
    W T Liao
    Department of Environmental Engineering, National Cheng Kung University, Tainan 70101, Taiwan
    Environ Technol 22:165-73. 2001
    A radio frequency (RF) plasma system was used to decompose the ethylene oxide (EO) contained gas in the EO/Ar, and EO/O2/Ar system, respectively...
  99. ncbi Comparative wear and wear debris under three different counterface conditions of crosslinked and non-crosslinked ultra high molecular weight polyethylene
    M M Endo
    School of Mechanical Engineering, University of Leeds, UK
    Biomed Mater Eng 11:23-35. 2001
    ..vacuum gamma irradiated), GUR 1120 crosslinked (acetylene enhanced irradiated) and non cross linked (ethylene oxide sterilised) GUR 1020 UHMWPE was compared in multidirectional pin-on-plate wear tests under three different ..
  100. ncbi The performance of gamma- and EtO-sterilised UHWMPE acetabular cups tested under severe simulator conditions. Part 1: role of the third-body wear process
    S Affatato
    Laboratorio di Tecnologia Medica, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Biomaterials 23:4839-46. 2002
    ..In order to evaluate the influence of the sterilisation method (gamma-irradiation and ethylene oxide(EtO)-treatment) and third-body particles on the ultra-high-molecular-weight-polyethylene wear behaviour, gamma-..
  101. ncbi Exposure of hematopoietic stem cells to ethylene oxide during processing represents a potential carcinogenic risk for transplant recipients
    Byron E Butterworth
    Butterworth Consulting, 4820 Regalwood Dr, Raleigh, NC 27613, USA
    Regul Toxicol Pharmacol 49:149-53. 2007
    ..Sterilization of disposables with ethylene oxide is widespread, even though those sets unavoidably retain residual amounts of ethylene oxide which is a potent, ..

Research Grants62

  1. INFLAMATION AND INFECTION ON BIOMATERIALS
    ERIC KALER; Fiscal Year: 2001
    ..SAMs will be synthesized with various functionalities including ethylene oxide, phosphorylcholine, and the Arg-Gly-Asp peptide sequence...
  2. A New Method for Sterilizing Biomedical Materials
    PENNY STARKEY; Fiscal Year: 2002
    ..that would be compatible with emerging biomaterials and biomimetic structures and would eventually replace ethylene oxide as a sterilization method. In particular, sterilization of the new synthetic extracellular matrix, a.k.a...
  3. Prospective studies of cancer etiology and prevention in Shanghai and Singapore
    Jian Min Yuan; Fiscal Year: 2013
    ..assess the independent role of polycyclic aromatic hydrocarbons (PAH), 1,3-butadiene, acrolein, benzene, and ethylene oxide in the development of lung cancer among smokers;(2) to assess independent role of PAH, 1,3-butadiene, acrolein,..
  4. Nanopolymersomes for Transcutaneous Co-Delivery of Vaccine Antigens and Adjuvants
    PAUL CAMILLE TUMEH; Fiscal Year: 2013
    ..The antigen/adjuvant co-delivery NPS comprised entirely of an amphiphilic diblock copolymer poly(ethylene oxide) (PEO) and polycaprolactone (PCL), will penetrate the stratum corneum to reach the vital epidermis and induce ..
  5. Extracellular Scaffold Elasticity and Binding Sites in Acinar Differentiation
    Melinda Larsen; Fiscal Year: 2013
    ..polymerase chain reaction;PEG-DMA, PEG-dimethylacrylate;PEG-TMA, PEG-trimethylacrylate;OMMA, oxiran-2-ylmethyl methacrylate;POMO, 2-((prop-2-ynyloxy)methyl)oxirane;SMG, submandibular salivary gland;transepithelial resistance, TER ..
  6. DNA cross-linking by diepoxybutane
    Natalia Y Tretyakova; Fiscal Year: 2013
    ..PERFORMANCE SITE(S) (organization, city, state) The Cancer Center, University of Minnesota Minneapolis, Minnesota ..
  7. A New Low Power Low Cost Ozone Sterilizer for Medical Equipment
    Joseph R Stetter; Fiscal Year: 2012
    ..Medical sterilizers available on the market today are primarily steam-based, with ethylene oxide and hydrogen peroxide plasma as other alternatives...
  8. Investigation of unusual cyclization reactions in biocatalysis
    Hung wen Liu; Fiscal Year: 2013
    ....
  9. Polypeptide modification for enhanced brain delivery
    Alexander V Kabanov; Fiscal Year: 2013
    ..The goal is achieved by modification of polypeptides with Pluronic copolymers (poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide))...
  10. Feasibility of Supercritical Carbon Dioxide Sterilization for Absorbable Suture M
    JANET L HUIE; Fiscal Year: 2013
    ..b>Ethylene oxide (ETO) and gamma irradiation ([unreadable] irradiation) are the only technologies commercially available for ..
  11. PLASMA PROTEINS: MARKERS OF CHEMICAL EXPOSURE
    GHULAM ANSARI; Fiscal Year: 1991
    ..chemicals containing functional groups such as aldehyde (acrolein, formaldehyde, and glutaraldehyde), epoxide (ethylene oxide, propylene oxide, and styrene oxide), and hydrocarbon (benzene, styrene, and butadiene) will be used as model ..
  12. Oxarane-Acrylate System to Double the Clinical Service Life of Restorative Resins
    H Ralph Rawls; Fiscal Year: 2013
    ..The best performing OASys will be tested in three in vivo biocompatibility models: delayed-type hypersensitivity, oral mucosa irritation, and pulp and dentin response tests. 1 ..
  13. Efficient Cellular Delivery of Oligonucleotides
    Charles M Roth; Fiscal Year: 2010
    ..Our very promising Preliminary Results were based on a single composition of ethylene oxide/propylene oxide groups in the poly (oxyalkylene amine) grafted onto PPAA...
  14. Sensitizer Delivery for Focused Hyperthermia Cancer Treatment
    Agata A Exner; Fiscal Year: 2013
    ..interventional radiology, and biomaterials science, this proposal will investigate local delivery of poly (ethylene oxide)-poly (propylene oxide) block copolymers for the enhancement of image guided RF ablation of tumors...
  15. SIGNIFICANCE OF EPOXIDE GENERATED 3-ALKYL-URACIL IN DNA
    JEROME SOLOMON; Fiscal Year: 1999
    ..We have found in studies conducted in vitro that cytosine residues initially alkylated by the epoxides ethylene oxide (EO), propylene oxide (PO), and epichlorhydrin (ECH) undergo rapid hydrolytic deamination to form stable 3- ..
  16. ARTIFICIAL POLYMERIC LIPOPROTEINS AS DRUG CARRIERS
    GLEN KWON; Fiscal Year: 2002
    ..Poly(ethylene oxide)-block-poly(L amino acid) (PEO-b-PLAA) self-assembles into micelles, supramolecular core/shell structures, ..
  17. HIGH-PERFORMANCE STERILANT GAS FOR DIALYSIS MEMBRANES
    JONATHAN NIMITZ; Fiscal Year: 2005
    ..The new sterilant gas should be marketable worldwide and should allow use of existing ethylene oxide (EO) sterilizing equipment, thus reducing costs of medical care...
  18. LOW-DOSE RADIATION STERILIZATION
    SHALABY SHALABY; Fiscal Year: 2000
    b>Ethylene oxide (ETO) and gamma-irradiation (GR) are most commonly used for device sterilization by the biomedical industry...
  19. Engineered Spores as Fluorogenic Biological Indicators for Sterility Testing
    Boris Rotman; Fiscal Year: 2007
    ..Task 3. Conduct experiments designed to extend the use of F-spores for sterilization processes using ethylene oxide, hydrogen peroxide gas plasma, and radiation...
  20. HIGH-PERFORMANCE STERILANT GAS FOR DIALYSIS MEMBRANES
    JONATHAN NIMITZ; Fiscal Year: 2001
    ..b>Ethylene oxide (EO) remains the sterilant of choice for these membranes...
  21. OVERALL HEMOCOMPATIBILITY PEO-FUNCTIONALIZED SILOXANES
    William Collins; Fiscal Year: 2001
    ..the biocompatibility of an exciting family of biomaterials, polydimethylsiloxanes end-functionalized with poly(ethylene oxide) (PEO siloxanes), to further such design...
  22. OVERALL HEMOCOMPATIBILITY PEO-FUNCTIONALIZED SILOXANES
    William Collins; Fiscal Year: 2003
    ..the biocompatibility of an exciting family of biomaterials, polydimethylsiloxanes end-functionalized with poly(ethylene oxide) (PEO siloxanes), to further such design...
  23. PEG Hydrogels for Tissue Engineering of Cartilage
    Susan Riley; Fiscal Year: 2001
    ..that a semi-interpenetrating polymer network composed of poly(ethylene glycol) dimethacrylate and poly(ethylene oxide) (MW<2OkDa) can provide a temporary biocompatible matrix for the production of tissue-engineered cartilage ..
  24. In-Vivo Study of an Oxirane Low Shrink-Stress Composite
    JOHN PURK; Fiscal Year: 2009
    ....
  25. A Bioscaffold for Repair of Congenital Defects
    Alan Spievack; Fiscal Year: 2001
    ..Secondly, we will evaluate the effect of two different methods of sterilization, gamma irradiation and ethylene oxide, upon the mechanical strength of the prototype UBM device...
  26. Improved Polymeric Restoratives Through Molecular Design
    J Eick; Fiscal Year: 2005
    ..Also, dental care for the general public will be substantially improved and a suitable replacement for dental amalgam will be available. ..
  27. Tape Mechanical Occlusive Device (TMOD)
    GERALD TIMM; Fiscal Year: 2006
    ..b>Ethylene Oxide sterilization processes will be validated during the course of the grant and used to sterilize TMOD devices in ..
  28. High and Low Frequency Scanning Acoustic Microscopes
    Paulette Spencer; Fiscal Year: 2002
    ..These measurements will e completed not only on the same specimen but the same small region of the interface. ..
  29. LONG-CIRCULATING TUMOR-SELECTIVE DNA DELIVERY SYSTEMS
    Mansoor Amiji; Fiscal Year: 2005
    ..in the systemic circulation, long-circulating poly (ethylene glycol)-grafted (PEGylated) gelatin and poly (ethylene oxide) (PEO)-modified poly (beta-amino ester) nanoparticles will be taken up by the tumor mass due to the enhanced ..
  30. Nanostructured Dental Composite Restorative Materials
    J Eick; Fiscal Year: 2009
    ....
  31. THE ROLE OF DNA ADDUCTS IN ETHYLENEOXIDE EXPOSURE
    DAVID LUDLUM; Fiscal Year: 1990
    b>Ethylene oxide, a widely-used chemical intermediate and fumigant, is carcinogenic to animals and is "probably carcinogenic to humans," according to the IARC...
  32. Biotech Center Barrier Improvement Project
    Joseph Newsome; Fiscal Year: 2009
    ..The existing ethylene oxide sterilizer in Biotech Center is obsolete and became nonfunctional 3 years ago...
  33. DEVELOPMENT OF INSTRUMENTS TO MEASURE HUMAN EXPOSURE
    JOSEPH STETTER; Fiscal Year: 1991
    ..and test recording dosimeters for carbon monoxide, nitrogen dioxide, hydrogen sulfide, formaldehyde, and ethylene oxide. These dosimeters will employ miniaturized amperometric gas sensors and even smaller microfabricated sensors ..
  34. Enhanced Management of Ethylene Oxide Sterilizers
    Sudipto Majumdar; Fiscal Year: 2005
    The effectiveness of ethylene oxide (EtO) for destroying pathogens in the case of heat and moisture sensitive materials has led to its wide spread use in sterilization processes...
  35. A New Artificial Corneal Prosthesis (kPro)
    Thomas White; Fiscal Year: 2002
    ..5-0.7mm with strength of 50 Newtons; 3) an independent laboratory determination of bioburden and ethylene oxide sterilization validation, and toxicology testing...
  36. LITHIUM-SELECTIVE ELECTRODES WITH POLYMERIC IONOPHORES
    Paul Hale; Fiscal Year: 1993
    ..of the most promising family of lithium ionophores by covalent attachment of the ionophores to flexible ethylene oxide and siloxane polymers...
  37. CHEMICAL DIGESTION-GC/MS ANALYSIS OF DNA ADDUCTS
    Roger Giese; Fiscal Year: 1990
    ..will be applied to aliphatic adducts arising from exposure to methylating agents, ethylating agents, and ethylene oxide. For both aromatic and aliphatic adducts, there is a long term potential for the methodology to define the ..
  38. BATZELLADINE A FOR SELECTIVE ANTIHIV DRUG DELIVERY
    DAVID GIN; Fiscal Year: 2002
    ..Preparation of the block-copolymer for micelle construction involves the synthesis of poly(ethylene oxide)-poly(b-benzyl-L-aspartate) block copolymer, whose size, stability and drug housing capacity present an ..
  39. Thromboresistant vascular grafts:heparin-peptidomimetics
    PAUL ZAMORA; Fiscal Year: 2004
    ..will also be conducted to establish if the peptide/heparin-coated graft can withstand sterilization with ethylene oxide, the preferred sterilization route for ePTFE...
  40. Terminal Sterilization of Tendon Allografts with C02
    TIMOTHY CHRISTENSEN; Fiscal Year: 2005
    ..Terminal sterilization using ethylene oxide gas leaves toxic residues and negatively impacts the probability of positive outcomes following ACL surgeries...
  41. Peptide Based Antibacterial Coating
    JENNIFER NEFF; Fiscal Year: 2005
    ..I, chemically-modified peptide derivatives will be covalently bound to immobilized, end-group activated poly(ethylene oxide) chains...
  42. DEVELOPMENT OF A LOW-COST ETHYLENE OXIDE DETECTOR
    David Hyatt; Fiscal Year: 1990
    ..to demonstrate the feasibility and develop towards commercialization a low-cost, reliable detector to monitor ethylene oxide (EtO) down to the 0.1 ppm level...
  43. MECHANISMS OF AT TA MUTAGENESIS IN EUKARYOTES
    Opinder Bhanot; Fiscal Year: 1999
    ..In studies with other lesions (m6G and several from ethylene oxide) the principal investigator has demonstrated his ability to build such oligonucleotides into shuttle plasmids ..
  44. A BIOMIMETIC BARRIER FOR ISLET IMMUNOISOLATION
    Elliot Chaikof; Fiscal Year: 2002
    ..2) Define the transport characteristics of dendrimer based molecular channels. Poly(ethylene oxide) (PEO) dendrimers with macromolecular generations will be synthesized, end-functionalized with a polymerizable ..
  45. HANDHELD MONITOR FOR ETHYLENE OXIDE IN HOSPITALS
    WILLIAM PENROSE; Fiscal Year: 1990
    b>Ethylene oxide (EtO) is a useful agent for sterilizing medical equipment because it involves no heat and is not corrosive to most materials...
  46. MULTIFUNCTIONAL ANTITHROMBOGENIC SURFACES
    CLIFTON SANDERS; Fiscal Year: 1990
    ..of this proposal is the methodology development and manufacturing of antithrombogenic surfaces containing poly(ethylene oxide)- tethered bioactive compounds that counteract or inhibit the major thrombogenic effects known to occur when a ..
  47. EVALUATING EXPOSURES UNDER OSHAS 1984 ETO STANDARD
    Robert Herrick; Fiscal Year: 2001
    We propose to conduct a historical evaluation of worker exposures under OSHA's 1984 ethylene oxide (EtO) standard. Most potentially-exposed workers are women employed in the hospital sector where EtO is used to sterilize medical devices...
  48. Development of Nanoscale Neuromodulationg Platforms
    DAVID PEPPERBERG; Fiscal Year: 2003
    ..GABAc receptors) expressed in Xenopus oocytes. The platform's active surface will consist of alkyl and poly(ethylene oxide) chains that are covalently linked to the surface, derivatized with a ferrocene/ferricinium moiety, and ..
  49. TUMOR REMISSION--TAXOL AND CLOSE ANALOGS VIA SYNTHESIS
    LEO PAQUETTE; Fiscal Year: 2003
    ..These include, but are not limited to, the 1-deoxy, D-homo-, 2-desmethyl, and 12-methylene derivatives, in addition to the D-ring invertomer and the C-nor isomer. ..
  50. DIRECT OBSERVATION OF INTERFACIAL PROCESS
    Vladimir Hlady; Fiscal Year: 2003
    ..Build a dynamic model of events based on the information that includes the two-dimensional map of biomaterial surface properties and the spatial-temporal distribution of individual plasma proteins. ..
  51. Chemopreventive Efficacy of Broccoli Sprouts in Humans
    Thomas Kensler; Fiscal Year: 2004
    ..abstract_text> ..
  52. Fourth International Nanomedicine and Drug Delivery Symposium
    Alexander Kabanov; Fiscal Year: 2006
    ..In the final analysis achieving the aim of the conference will contribute to the development of novel nanoscale delivery technologies for diagnostics and therapeutics that address unmet clinical needs. [unreadable]..
  53. Protection by Induction of Ubiquitin-Proteasome Systems
    Thomas Kensler; Fiscal Year: 2005
    ....
  54. 6th International Nanomedicine and Drug Delivery Symposium
    Alexander Kabanov; Fiscal Year: 2008
    ..e. graduate students and post-doctoral fellows) to present their research at the international level and interact with other new promising investigators and world-renowned scientists. [unreadable] [unreadable] [unreadable]..
  55. SCREENING PLATELETS INTERACTIONS WITH SURFACE GRADIENTS
    Vladimir Hlady; Fiscal Year: 2009
    ....
  56. NIR-Emissive Polymersomal Markers for Molecula-Level Detection of Metastasis
    Michael Therien; Fiscal Year: 2009
    ....
  57. ACOUSTICALLY ACTIVATED MICELLAR DRUG DELIVERY
    Natalya Y Rapoport; Fiscal Year: 2010
    ....
  58. Cross-linked Polymer Micelles in Cancer Therapy
    Tatiana K Bronich; Fiscal Year: 2010
    ..The nanofabrication of these micelles involves condensation of diblock copolymers of poly(ethylene oxide) (PEO) and poly(carboxylic acid) by divalent metal cations into spherical micelles of core-shell morphology...
  59. Interactions of Block Copolymers in Blood Brain Barrier
    Alexander Kabanov; Fiscal Year: 2006
    ..the brain delivery of drugs across the blood brain barrier (BBB) using a novel drug delivery system, poly(ethylene oxide)-poly(propylene oxide) block copolymers (Pluronic) or "poloxamer")...