ethylene oxide

Summary

Summary: A colorless and flammable gas at room temperature and pressure. Ethylene oxide is a bactericidal, fungicidal, and sporicidal disinfectant. It is effective against most micro-organisms, including viruses. It is used as a fumigant for foodstuffs and textiles and as an agent for the gaseous sterilization of heat-labile pharmaceutical and surgical materials. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p794)

Top Publications

  1. ncbi Residual ethylene oxide in medical devices and device material
    Anne D Lucas
    Center for Devices and Radiological Health, Office of Science and Technology, U S Food and Drug Administration, Rockville, MD 20852, USA
    J Biomed Mater Res B Appl Biomater 66:548-52. 2003
  2. ncbi Effects of different sterilization methods on the morphology, mechanical properties, and cytotoxicity of chitosan membranes used as wound dressings
    Paula Rulf Marreco
    Department of Biotechnological Processes, School of Chemical Engineering, PO Box 6066, State University of Campinas, Sao Paulo, 13081 970, Brazil
    J Biomed Mater Res B Appl Biomater 71:268-77. 2004
  3. ncbi OSHA compliance: issues ethylene oxide in a commercial sterilization operation
    George Daniel
    US Department of Labor, Occupational Safety and Health Administration, St Louis Area Office, St Louis, Missouri, USA
    J Occup Environ Hyg 1:D121-5. 2004
  4. doi Analysis of hemoglobin adducts from acrylamide, glycidamide, and ethylene oxide in paired mother/cord blood samples from Denmark
    Hans von Stedingk
    Department of Materials and Environmental Chemistry, Environmental Chemistry Unit, Arrhenius Laboratory, Stockholm University, SE 106 91 Stockholm, Sweden
    Chem Res Toxicol 24:1957-65. 2011
  5. ncbi Effect of ethylene oxide and propylene oxide block copolymers on the permeability of bilayer lipid membranes to small solutes including doxorubicin
    V Y Erukova
    A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow 119899, Russia
    Biochim Biophys Acta 1468:73-86. 2000
  6. ncbi Modulation of lymphatic distribution of subcutaneously injected poloxamer 407-coated nanospheres: the effect of the ethylene oxide chain configuration
    S M Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton BN2 4GJ, UK
    FEBS Lett 540:241-4. 2003
  7. ncbi Increase in early polyethylene wear after sterilization with ethylene oxide: radiostereometric analyses of 201 total hips
    Georgios Digas
    Department of Orthopaedics, Institute of Surgical Science, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
    Acta Orthop Scand 74:531-41. 2003
  8. ncbi Effect of ethylene oxide sterilization on enamel and dentin demineralization in vitro
    Renske Z Thomas
    Department of Dentistry and Dental Hygiene, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    J Dent 35:547-51. 2007
  9. ncbi Ethylene oxide sterilization of medical devices: a review
    Gisela C C Mendes
    Universidade Catolica Portuguesa, Escola Superior de Biotecnologia, Porto, Portugal
    Am J Infect Control 35:574-81. 2007
  10. ncbi Reproductive and developmental risks from ethylene oxide: a probabilistic characterization of possible regulatory thresholds
    J S Evans
    Harvard School of Public Health, Boston, MA, USA
    Risk Anal 21:697-717. 2001

Research Grants

Detail Information

Publications243 found, 100 shown here

  1. ncbi Residual ethylene oxide in medical devices and device material
    Anne D Lucas
    Center for Devices and Radiological Health, Office of Science and Technology, U S Food and Drug Administration, Rockville, MD 20852, USA
    J Biomed Mater Res B Appl Biomater 66:548-52. 2003
    b>Ethylene oxide (EO) gas is commonly used to sterilize medical devices. The amount of residual EO remaining in a device depends partly on the type and size of polymeric material...
  2. ncbi Effects of different sterilization methods on the morphology, mechanical properties, and cytotoxicity of chitosan membranes used as wound dressings
    Paula Rulf Marreco
    Department of Biotechnological Processes, School of Chemical Engineering, PO Box 6066, State University of Campinas, Sao Paulo, 13081 970, Brazil
    J Biomed Mater Res B Appl Biomater 71:268-77. 2004
    ..work was to compare the effects induced by two different sterilization methods (exposure to gamma radiation or ethylene oxide) and an antiseptic technique (immersion in 70% ethanol aqueous solution) on the morphology, tensile strength, ..
  3. ncbi OSHA compliance: issues ethylene oxide in a commercial sterilization operation
    George Daniel
    US Department of Labor, Occupational Safety and Health Administration, St Louis Area Office, St Louis, Missouri, USA
    J Occup Environ Hyg 1:D121-5. 2004
  4. doi Analysis of hemoglobin adducts from acrylamide, glycidamide, and ethylene oxide in paired mother/cord blood samples from Denmark
    Hans von Stedingk
    Department of Materials and Environmental Chemistry, Environmental Chemistry Unit, Arrhenius Laboratory, Stockholm University, SE 106 91 Stockholm, Sweden
    Chem Res Toxicol 24:1957-65. 2011
    ..Acrylamide, glycidamide, and ethylene oxide are electrophiles and form adducts with hemoglobin (Hb), which could be used for in vivo dose measurement...
  5. ncbi Effect of ethylene oxide and propylene oxide block copolymers on the permeability of bilayer lipid membranes to small solutes including doxorubicin
    V Y Erukova
    A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow 119899, Russia
    Biochim Biophys Acta 1468:73-86. 2000
    The effects of ethylene oxide and propylene oxide block copolymers (pluronics) on the permeability of several weak acids and bases through bilayer lipid membranes have been studied by the methods of monitoring (1) pH shifts near planar ..
  6. ncbi Modulation of lymphatic distribution of subcutaneously injected poloxamer 407-coated nanospheres: the effect of the ethylene oxide chain configuration
    S M Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton BN2 4GJ, UK
    FEBS Lett 540:241-4. 2003
    ..injected poloxamer 407-coated nanospheres (45 nm in diameter) is controlled by surface configuration of the ethylene oxide (EO) segments of the adsorbed copolymer...
  7. ncbi Increase in early polyethylene wear after sterilization with ethylene oxide: radiostereometric analyses of 201 total hips
    Georgios Digas
    Department of Orthopaedics, Institute of Surgical Science, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
    Acta Orthop Scand 74:531-41. 2003
    ..Moreover, 37 cemented cups were sterilized with ethylene oxide (Reflection all-poly) and 69 porous-coated cups had liners sterilized in ethylene oxide (Reflection)...
  8. ncbi Effect of ethylene oxide sterilization on enamel and dentin demineralization in vitro
    Renske Z Thomas
    Department of Dentistry and Dental Hygiene, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    J Dent 35:547-51. 2007
    ..The aim of this study was to assess the effect of sterilising sound human enamel and dentin with ethylene oxide on lesion depth and mineral loss before and after in vitro demineralization...
  9. ncbi Ethylene oxide sterilization of medical devices: a review
    Gisela C C Mendes
    Universidade Catolica Portuguesa, Escola Superior de Biotecnologia, Porto, Portugal
    Am J Infect Control 35:574-81. 2007
    b>Ethylene oxide (EO) is a well-known sterilizing agent. However, only recently has its use significantly emerged, based on its range of applications in the field of new medical device development and sterilization...
  10. ncbi Reproductive and developmental risks from ethylene oxide: a probabilistic characterization of possible regulatory thresholds
    J S Evans
    Harvard School of Public Health, Boston, MA, USA
    Risk Anal 21:697-717. 2001
    b>Ethylene oxide is a gas produced in large quantities in the United States that is used primarily as a chemical intermediate in the production of ethylene glycol, propylene glycol, non-ionic surfactants, ethanolamines, glycol ethers, and ..
  11. pmc Reciprocal translocations in somatic and germ cells of mice chronically exposed by inhalation to ethylene oxide: implications for risk assessment
    E Maria Donner
    The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    Mutagenesis 25:49-55. 2010
    Groups of male B6C3F1 mice were exposed by inhalation to 0, 25, 50, 100 or 200 p.p.m. ethylene oxide (EO) for up to 48 weeks (6 hours/day, 5 days/week)...
  12. ncbi Novel hydrogel membrane based on copoly(hydroxyethyl methacrylate/p-vinylbenzyl-poly(ethylene oxide)) for biomedical applications: properties and drug release characteristics
    M Yakup Arica
    Biochemical Processing and Biomaterial Research Laboratory, Faculty of Science, Kirikkale University, 71450 Yahşihan Kirikkale, Turkey
    Macromol Biosci 5:983-92. 2005
    ..in the membrane form using 2-hydroxyethyl methacrylate monomer (HEMA) and a macromonomer p-vinylbenzyl-poly(ethylene oxide) (V-PEO) via photoinitiated polymerization...
  13. ncbi Increased genotoxic susceptibility of breast epithelial cells to ethylene oxide
    Balázs Adám
    Department of Preventive Medicine, School of Public Health, Medical and Health Science Center, University of Debrecen, P O Box 9, H 4012, Debrecen, Hungary
    Mutat Res 585:120-6. 2005
    This study was carried out with the aim of elucidating the organ-specific effects of ethylene oxide in comparison with the sensitivity of cells from different tissues...
  14. ncbi Frequent p53 and H-ras mutations in benzene- and ethylene oxide-induced mammary gland carcinomas from B6C3F1 mice
    Christopher D Houle
    Laboratory of Experimental Pathology, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 34:752-62. 2006
    Benzene and ethylene oxide are multisite carcinogens in rodents and classified as human carcinogens by the National Toxicology Program. In 2-year mouse studies, both chemicals induced mammary carcinomas...
  15. pmc Cancer incidence and mortality in Swedish sterilant workers exposed to ethylene oxide: updated cohort study findings 1972-2006
    Zoli Mikoczy
    Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, and Occupational and Environmental Medicine, Skane University Hospital, SE 221 85 Lund, Sweden
    Int J Environ Res Public Health 8:2009-19. 2011
    ..cancer incidence, mainly from lymphohaematopoietic tumours and breast cancer, and mortality were increased in a cohort of Swedish sterilant workers exposed to low levels of ethylene oxide (EtO), updated with 16 more years of follow up.
  16. ncbi An evaluation of the capacity of differently prepared demineralised bone matrices (DBM) and toxic residuals of ethylene oxide (EtOx) to provoke an inflammatory response in vitro
    R J Lomas
    Yorkshire Regional Tissue Bank, National Blood Service, Pinderfields General Hospital, Wakefield, UK
    Biomaterials 22:913-21. 2001
    ..There is a long history of controversy relating to the suitability of ethylene oxide gas (EtOx) as a terminal sterilisation agent for this graft, relating to its effects on the clinical ..
  17. ncbi Bromoethane, chloroethane and ethylene oxide induced uterine neoplasms in B6C3F1 mice from 2-year NTP inhalation bioassays: pathology and incidence data revisited
    Catherine A Picut
    Biotechnics, Inc, Hillsborough, North Carolina, USA
    Exp Toxicol Pathol 55:1-9. 2003
    Chloroethane, bromoethane and ethylene oxide represent a unique set of chemicals that induce endometrial neoplasms in the uterus of B6C3F1 mice following an inhalation route of exposure...
  18. ncbi Mechanical strength of cortical allografts with gamma radiation versus ethylene oxide sterilization
    Zongke Zhou
    Department of Orthopaedic Surgery, West China Hospital of Sichuan University, Chengdu, China
    Acta Orthop Belg 77:670-5. 2011
    We investigated the effects of gamma irradiation versus ethylene oxide (ETO) sterilization on the mechanical strength of cortical bone grafts. Tibias were collected from cadavers of mature goats...
  19. ncbi Relevance of the deletion polymorphisms of the glutathione S-transferases GSTT1 and GSTM1 in pharmacology and toxicology
    H M Bolt
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany
    Curr Drug Metab 7:613-28. 2006
    ..This appears relevant in industrial toxicology and in drug metabolism...
  20. ncbi Exposure to ethylene oxide in hospitals: biological monitoring and influence of glutathione S-transferase and epoxide hydrolase polymorphisms
    Vincent Haufroid
    Industrial Toxicology and Occupational Medicine Unit, Catholic University of Louvain, Brussels, Belgium
    Cancer Epidemiol Biomarkers Prev 16:796-802. 2007
    b>Ethylene oxide is considered as a human carcinogen. A biomarker of exposure would be a useful instrument to assess the risk in occupationally exposed workers...
  21. ncbi Hyaluronic acid hydrogel in the treatment of osteoarthritis
    R Barbucci
    Department of Chemical and Biosystem Sciences and Technology, CRISMA, University of Siena, Italy
    Biomaterials 23:4503-13. 2002
    ..Liophilised Hyal 50% samples were sterilised by steam, Ethylene Oxide (EtO) and gamma-rays...
  22. ncbi Release of anti-restenosis drugs from poly(ethylene oxide)-poly(DL-lactic-co-glycolic acid) nanoparticles
    Miechel L T Zweers
    Department of Polymer Chemistry and Biomaterials, Institute for Biomedical Technology, Faculty of Science and Technology, University of Twente, PO Box 217, 7500 AE Enschede, The Netherlands
    J Control Release 114:317-24. 2006
    Dexamethasone- or rapamycin-loaded nanoparticles based on poly(ethylene oxide) and poly(dl-lactic-co-glycolic acid) block copolymers (PEO-PLGA) were prepared without additional stabilizer using the salting-out method...
  23. doi Sustained and extended release with structural and activity recovery of lysozyme from complexes with sodium (sulfamate carboxylate) isoprene/ethylene oxide block copolymer
    Gao Gao
    Key Laboratory of Molecular Engineering of Polymers, and Department of Macromolecular Science, Fudan University, Shanghai 200433, China
    Macromol Biosci 10:139-46. 2010
    The complexation of lysozyme and sodium (sulfamate carboxylate) isoprene/ethylene oxide (SCIEO) at pH = 7.4 and the release of lysozyme from the complexes in the presence of NaCl were investigated...
  24. pmc Mortality analyses in a cohort of 18 235 ethylene oxide exposed workers: follow up extended from 1987 to 1998
    K Steenland
    Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    Occup Environ Med 61:2-7. 2004
    To extend mortality follow up from 1987 to 1998 for cohort of 18 235 men and women exposed to ethylene oxide.
  25. ncbi DNA adducts in granulocytes of hospital workers exposed to ethylene oxide
    Lee C Yong
    Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, CDC, Cincinnati, Ohio 45226, USA
    Am J Ind Med 50:293-302. 2007
    b>Ethylene oxide (EtO), an important industrial chemical intermediate and sterilant, is classified as a human carcinogen...
  26. ncbi DNA adducts: effects of low exposure to ethylene oxide, vinyl chloride and butadiene
    J A Swenberg
    Department of Environmental Sciences and Engineering, University of North Carolina, Campus Box 7400, Chapel Hill, NC 27599, USA
    Mutat Res 464:77-86. 2000
    ..formed DNA adducts may be identical to those formed by chemicals, as in the case of vinyl chloride and ethylene oxide, or they may be those associated with oxidative stress...
  27. ncbi Effects of ethylene oxide and ethylene inhalation on DNA adducts, apurinic/apyrimidinic sites and expression of base excision DNA repair genes in rat brain, spleen, and liver
    Ivan Rusyn
    Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    DNA Repair (Amst) 4:1099-110. 2005
    b>Ethylene oxide (EO) is an important industrial chemical that is classified as a known human carcinogen (IARC, Group 1)...
  28. ncbi Detection of viable fungal spores contaminant on documents and rapid control of the effectiveness of an ethylene oxide disinfection using ATP assay
    Malalanirina S Rakotonirainy
    Centre de Recherches sur la Conservation des Documents Graphiques CRCDG, MNHN MCC CNRS UMR 8573, 36 rue Geoffroy Saint Hilaire, 75005 Paris, France
    Luminescence 18:113-21. 2003
    ..The validity of the procedure was also tested on spores killed by steam and on spores treated with ethylene oxide. We showed that EC determination could be used for a rapid control of the effectiveness of a disinfection ..
  29. ncbi Formation of tetra(ethylene oxide) terminated Si-C linked monolayers and their derivatization with glycine: an example of a generic strategy for the immobilization of biomolecules on silicon
    Till Böcking
    School of Physics and School of Chemistry, University of New South Wales, Sydney, Australia
    Langmuir 21:10522-9. 2005
    Surface modification with oligo(ethylene oxide) functionalized monolayers terminated with reactive headgroups constitutes a powerful strategy to provide specific coupling of biomolecules with simultaneous protection from nonspecific ..
  30. ncbi The effect of ethylene exposure on ethylene oxide in blood and on hepatic cytochrome p450 in Fischer rats
    Timothy R Fennell
    CIIT Centers for Health Research, Research Triangle Park, NC 27709, USA
    Toxicol Sci 81:7-13. 2004
    Ethylene (74-85-1) is an important petrochemical and is produced endogenously. It is metabolized to ethylene oxide (EO) by cytochrome P450...
  31. ncbi Dose-dependent influence of genetic polymorphisms on DNA damage induced by styrene oxide, ethylene oxide and gamma-radiation
    Lode Godderis
    Katholieke Universiteit Leuven K U L, Laboratorium Voor Arbeidshygiëne en Toxicologie, Kapucijnenvoer 35 6, 3000 Leuven, Belgium
    Toxicology 219:220-9. 2006
    Styrene oxide (SO), ethylene oxide (EO) and gamma-radiation (G) are agents with a well-described metabolism and genotoxicity. EPHX1 and GSTs play an important role in the detoxification of electrophiles and oxidative stress...
  32. ncbi Genotoxic effects of ethylene oxide, propylene oxide and epichlorohydrin in humans: update review (1990-2001)
    Ada Kolman
    Department of Molecular Biology and Functional Genomics, Stockholm University, SE 106 91, Stockholm, Sweden
    Mutat Res 512:173-94. 2002
    b>Ethylene oxide (EtO), propylene oxide (PO) and epichlorohydrin (ECH) are important industrial chemicals widely used as intermediates for various synthetic products. EtO and PO are also environmental pollutants...
  33. pmc Ethylene oxide and cancer
    O Axelson
    Occup Environ Med 61:1. 2004
  34. ncbi Biomarkers of exposure and effect as indicators of potential carcinogenic risk arising from in vivo metabolism of ethylene to ethylene oxide
    V E Walker
    Department of Pathology and Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7525, USA
    Carcinogenesis 21:1661-9. 2000
    ..potential use of several biomarkers as quantitative indicators of the in vivo conversion of ethylene (ET) to ethylene oxide (EO); (ii) to produce molecular dosimetry data that might improve assessment of human risk from exogenous ET ..
  35. ncbi Ethylene oxide gas sterilization: a simple technique for storing explanted skull bone. Technical note
    David H Jho
    Neurosurgical Service, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Neurosurg 107:440-5. 2007
    The authors evaluated the effectiveness of a simple technique using ethylene oxide (EtO) gas sterilization and room temperature storage of autologous bone grafts for reconstructive cranioplasty following decompressive craniectomy...
  36. ncbi Hemoglobin adducts of ethylene oxide, propylene oxide, acrylonitrile and acrylamide-biomarkers in occupational and environmental medicine
    Thomas Schettgen
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich Alexander University of Erlangen Nurnberg, Schillerstrasse 25 29, D 91054 Erlangen, Germany
    Toxicol Lett 134:65-70. 2002
    In a chemical plant, ethylene oxide (EO) and propylene oxide (PO) were used for the production of surfactants for the textile industry...
  37. ncbi Ethylene oxide sterilization in the medical-supply manufacturing industry: assessment and control of worker exposure
    Yeh Chung Chien
    Department of Industrial Safety and Health, Hungkuang University, Shalu, Taiwan
    J Biomed Mater Res B Appl Biomater 83:527-37. 2007
    ..and Health started an on-site consulting program for the medical supplies manufacturing industry, which use ethylene oxide (EO) as a sterilant, with the goal of enhancing occupational hygiene practices and controlling EO-related ..
  38. doi Effect of surface roughness and sterilization on bacterial adherence to ultra-high molecular weight polyethylene
    T J Kinnari
    Department of Clinical Microbiology, Fundacion Jimenez Diaz, Madrid, Spain
    Clin Microbiol Infect 16:1036-41. 2010
    Sterilization with ethylene oxide (EO) and gas plasma (GP) are well-known methods applied to ultra-high molecular weight polyethylene (UHMWPE) surfaces in the belief that they prevent major material changes caused by gamma irradiation...
  39. ncbi Ethylene oxide and breast cancer incidence in a cohort study of 7576 women (United States)
    Kyle Steenland
    National Institute for Occupational Safety and Health NIOSH, Cincinnati, Ohio 30322, USA
    Cancer Causes Control 14:531-9. 2003
    b>Ethylene oxide (ETO) is a sterilant gas considered to be a human carcinogen, due primarily to excess hematopoietic cancer in exposed cohorts...
  40. ncbi Hemoglobin adducts from acrylonitrile and ethylene oxide in cigarette smokers: effects of glutathione S-transferase T1-null and M1-null genotypes
    T R Fennell
    Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina 27709, USA
    Cancer Epidemiol Biomarkers Prev 9:705-12. 2000
    ..It is carcinogenic in rats and is found in cigarette smoke. Ethylene oxide (EO) is a metabolite of ethylene, also found in cigarette smoke, and is carcinogenic in rodents...
  41. pmc Mortality of workers exposed to ethylene oxide: extended follow up of a British cohort
    D Coggon
    MRC Environmental Epidemiology Unit, University of Southampton, UK
    Occup Environ Med 61:358-62. 2004
    To obtain further information about the risks of cancer associated with occupational exposure to ethylene oxide
  42. doi Comparative analysis of urinary N7-(2-hydroxyethyl)guanine for ethylene oxide- and non-exposed workers
    Chih Chun Jean Huang
    Department of Food Science, National Pingtung University of Science and Technology, 1 Shuefu Rd, Neipu, Pingtung 91201, Taiwan
    Toxicol Lett 202:237-43. 2011
    b>Ethylene oxide (EO), a direct alkylating agent and a carcinogen, can attack the nucleophilic sites of DNA bases to form a variety of DNA adducts...
  43. ncbi Personal exposure level and environmental ethylene oxide gas concentration in sterilization facilities of hospitals in Japan
    Hajime Hori
    Departament of Environmental Management, School of Health Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan
    Appl Occup Environ Hyg 17:634-9. 2002
    Personal and environmental (stationary) ethylene oxide (EO) gas concentrations in gas sterilization facilities were measured at six workplaces in five hospitals...
  44. ncbi Comparative sterilization effectiveness of plasma in O2-H2O2 mixtures and ethylene oxide treatment
    J M F Silva
    Laboratory of Medicine and Cosmetic Quality Control, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    PDA J Pharm Sci Technol 61:204-10. 2007
    ..the influence of variable parameters of plasma sterilization and compared its effectiveness with that of ethylene oxide using a reactive ion etching plasma reactor at 13.56 MHz...
  45. ncbi A physiologically based pharmacokinetic model for ethylene oxide in mouse, rat, and human
    T R Fennell
    CIIT Centers for Health Research, Research Triangle Park, North Carolina, 27709, USA
    Toxicol Appl Pharmacol 173:161-75. 2001
    b>Ethylene oxide (EO) is widely used as a gaseous sterilant and industrial intermediate and is a direct-acting mutagen and carcinogen...
  46. doi Mortality study update of ethylene oxide workers in chemical manufacturing: a 15 year update
    Gerard M H Swaen
    Department of Epidemiology, Health Services, The Dow Chemical Company, Midland, Mich, USA
    J Occup Environ Med 51:714-23. 2009
    To investigate the long-term mortality patterns of workers with past exposure to ethylene oxide (EO).
  47. doi Life-table calculations of excess risk for incidence versus mortality: ethylene oxide case study
    Robert L Sielken
    Sielken and Associates Consulting Inc, 3833 South Texas Avenue, Suite 230, Bryan, TX 77802, USA
    Regul Toxicol Pharmacol 55:82-9. 2009
    In US EPA's evaluation of ethylene oxide (EO) in 2006, the calculation of the excess risk of lymphohematopoietic (LH) cancer incidence was flawed...
  48. ncbi Oxidation in orthopaedic UHMWPE sterilized by gamma-radiation and ethylene oxide
    L Costa
    Dipartimento di Chimica Inorganica e Chimica Fisica dell Università di Torino, Italy
    Biomaterials 19:659-68. 1998
    Ten new polyethylene prosthetic components (PEs), ethylene oxide (EtO)- and gamma-sterilized, were studied by means of infrared (IR) analysis in order to evaluate oxidation...
  49. ncbi Sterilization and strength of 70/30 polylactide cages: e-beam versus ethylene oxide
    Theo H Smit
    Department of Physics and Medical Technology, VU University Medical Center, Amsterdam, The Netherlands
    Spine (Phila Pa 1976) 32:742-7. 2007
    ..In vitro and in vivo studies on the degradation of 70/30 poly(L,DL-lactide) (PLDLLA) cages...
  50. ncbi Stereospecific alkylation of cis-3-chloroacrylic acid dehalogenase by (R)-oxirane-2-carboxylate: analysis and mechanistic implications
    Gerrit J Poelarends
    Division of Medicinal Chemistry, College of Pharmacy, The University of Texas, Austin, Texas 78712 1074, USA
    Biochemistry 43:7187-96. 2004
    ..These findings set the stage for a crystallographic analysis of the inactived enzyme to delineate further the roles of active site residues in both the inactivation process and the catalytic mechanism...
  51. ncbi Block copolymers of ethylene oxide and phenyl glycidyl ether: micellization, gelation, and drug solubilization
    Pablo Taboada
    Department of Physics of Condensed Matter, University of Santiago de Compostela, E 15706 Santiago de Compostela, Spain
    Langmuir 21:5263-71. 2005
    Three triblock copolymers of ethylene oxide and phenyl glycidyl ether, type E(m)G(n)E(m), where G = OCH2CH(CH2OC6H5) and E = OCH2CH2, were synthesized and characterized by gel-permeation chromatography, matrix-assisted laser desorption ..
  52. ncbi Biomonitoring of exposure to ethylene oxide and propylene oxide by determination of hemoglobin adducts: correlations between airborne exposure and adduct levels
    P J Boogaard
    Department of Molecular Toxicology, Shell Research and Technology Center, Amsterdam Shell International Chemicals B V, The Netherlands
    Int Arch Occup Environ Health 72:142-50. 1999
    b>Ethylene oxide (EO) and propylene oxide (PO) are important industrial chemicals. Exposure to these directly acting mutagens may be monitored by determination of their adducts to hemoglobin (Hb)...
  53. ncbi Occupational exposure to ethylene oxide during pregnancy and association with adverse reproductive outcomes
    Daniela F Gresie-Brusin
    School of Public Health, University of the Witwatersrand, P O Box 2900, Johannesburg, 2132, South Africa
    Int Arch Occup Environ Health 80:559-65. 2007
    To investigate the association between exposure to ethylene oxide during pregnancy and adverse reproductive outcomes.
  54. ncbi Size control of styrene oxide-ethylene oxide diblock copolymer aggregates with classical surfactants: DLS, TEM, and ITC study
    Emilio Castro
    Grupo de Sistemas Complejos, Laboratorio de Física de Coloides y Polímeros, Departamento de Fisica de la Materia Condensada, Facultad de Fisica, Universidad de Santiago de Compostela, Spain
    Biomacromolecules 6:1438-47. 2005
    ..From that point, important differences in the ITC plot for both surfactants are present. However, the ITC curve obtained after titration of a SOS solution in the copolymer solution is quite similar to that of its titration in water...
  55. ncbi Crystal structures of native and inactivated cis-3-chloroacrylic acid dehalogenase. Structural basis for substrate specificity and inactivation by (R)-oxirane-2-carboxylate
    René M de Jong
    Laboratory of Biophysical Chemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    J Biol Chem 282:2440-9. 2007
    ..The involvement of His-28 and Tyr-103' distinguishes the cis-CaaD mechanism from the otherwise parallel CaaD mechanism. The two mechanisms probably evolved independently as the result of an early gene duplication of a common ancestor...
  56. ncbi A radiological evaluation of allografts (ethylene oxide sterilized cadaver bone) and autografts in anterior cervical fusion
    J K B C Parthiban
    Department of Neurosurgery, L T M Medical College and L T M G Hospital, Sion, Mumbai, 400103, India
    Neurol India 50:17-22. 2002
    Serial roentgenograms of 40 patients who had 70 cervical intervertebral spaces grafted with ethylene oxide sterilized cadaver bone and 28 patients who received 44 iliac crest auto grafts for anterior cervical spine fusion, were studied...
  57. ncbi Micellization and drug solubilization in aqueous solutions of a diblock copolymer of ethylene oxide and phenyl glycidyl ether
    Pablo Taboada
    Department of Physics of Condensed Matter, University of Santiago de Compostela, E 15706 Santiago de Compostela, Spain
    Langmuir 22:7465-70. 2006
    ..b>Ethylene oxide and phenyl glycidyl ether were sequentially polymerized to form the diblock copolymer G5E67 (G = phenyl ..
  58. ncbi Carcinogenicity of 1,3-butadiene, ethylene oxide, vinyl chloride, vinyl fluoride, and vinyl bromide
    Yann Grosse
    Lancet Oncol 8:679-80. 2007
  59. ncbi In vivo mutagenicity of ethylene oxide at the hprt locus in T-lymphocytes of B6C3F1 lacI transgenic mice following inhalation exposure
    V E Walker
    Department of Pathology, University of North Carolina at Chapel Hill, 27599 7525, USA
    Mutat Res 392:211-22. 1997
    b>Ethylene oxide (EO) is a direct-acting alkylating agent with the potential to induce cytogenetic alterations, mutations, and cancer...
  60. ncbi Preparation and characterization of nanoaggregates of poly(ethylene oxide)-b-polymethacrylate and poly-L-lysine
    Yuan Li
    Department of Chemistry, Faculty of Science and Engineering, Saga University, 1 Honjo Machi, Saga 840 8502, Japan
    J Colloid Interface Sci 264:561-4. 2003
    Poly(ethylene oxide)-b-polymethacrylate (PEO-b-PMA), one of the double-hydrophilic block copolymers, has proved to the form nanoaggregates with poly-L-lysine (PLS)...
  61. ncbi Sterlization techniques for the dental office
    Rodney M Stine
    Tex Dent J 121:240-2. 2004
  62. ncbi Safety evaluation of single-use medical devices after submission to simulated reutilization cycles
    Mônica Valero Da Silva
    Fundacao Universidade de Brasilia, Faculdade de Ciencias da Saude, Departamento de Farmacia, Campus Universitário Asa Norte, CEP 70910 900, Brazilia, DF, Brazil
    J AOAC Int 88:823-9. 2005
    ..cycles consisted of subsequent wash with enzymatic detergent followed by drying and sterilization with ethylene oxide-CFC (12 + 88), 600 mg/L at 55 degrees C, relative humidity 60%, for 3 h...
  63. ncbi Effectiveness of microwave sterilization on three hard chairside reline resins
    Karin Hermana Neppelenbroek
    Department of Dental Materials and Prosthodontics, Sao Paulo State University, Araraquara Dental School, Sao Paulo, Brazil
    Int J Prosthodont 16:616-20. 2003
    ..The aim of this study was to evaluate the effectiveness of microwave irradiation sterilization on hard chairside reline resins...
  64. pmc Effect of polyoxypropylene chain length on the critical micelle concentration of propylene oxide-ethylene oxide block copolymers
    Zhi Guo Zhang
    Department of Chemical Engineering, Zhejiang University, Hangzhou 310027, China
    J Zhejiang Univ Sci B 6:219-21. 2005
    ..The change in the work of cohesion per oxypropylene group when passing from molecular into micellar state, calculated from the Shinoda equation, was 0.43 kT for the studied compounds...
  65. ncbi In vitro cytotoxicity testing of AB-polymer networks based on oligo(epsilon-caprolactone) segments after different sterilization techniques
    Dorothee Rickert
    Department of Otolaryngology and Head and Neck Surgery, University of Ulm, Prittwitzstrasse 43, D 89075 Ulm, Germany
    J Biomed Mater Res B Appl Biomater 67:722-31. 2003
    ..The influence of the different sterilization techniques on the cytotoxicity of the polymeric material, as well as the clinical relevance of the described differences, are discussed...
  66. ncbi Factors affecting tailing in ethylene oxide sterilization part 1: When tailing is an artifact... and scientific deficiencies in ISO 11135 and EN 550
    Gregg A Mosley
    Biotest Laboratories, Inc, Minneapolis, MN, USA
    PDA J Pharm Sci Technol 58:81-95. 2004
    ..Application of these methods will allow more accurate calculations of process lethality that are supported by biological data and appropriate mathematical analyses...
  67. ncbi Electrospun three-dimensional hyaluronic acid nanofibrous scaffolds
    Yuan Ji
    Department of Materials Science and Engineering, SUNY at Stony Brook, Stony Brook, NY 11794 2275, USA
    Biomaterials 27:3782-92. 2006
    ..In order to facilitate the fiber formation during electrospinning, Poly (ethylene oxide) (PEO) was added into the aqueous solution of HA-DTPH at an optimal weight ratio of 1:1...
  68. ncbi Damage of office supply, personal use items, and over-the-counter medical devices after sterilization by ethylene oxide gas, electron beam, and gamma radiation
    Anne D Lucas
    U S Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Silver Spring, MD, USA
    Biomed Instrum Technol 38:476-84. 2004
    ..The effects of three sterilization methods (i.e. ethylene oxide gas [EO], electron beam [e-beam] radiation, and gamma radiation) were evaluated for a variety of office supply ..
  69. ncbi Effectiveness of microwave irradiation on the disinfection of complete dentures
    Mariana Montenegro Silva
    Department of Dental Materials and Prosthodontics, Araraquara Dental School, Sao Paulo State University, Brazil
    Int J Prosthodont 19:288-93. 2006
    ..The purpose of this study was to evaluate the effectiveness of microwave irradiation on the disinfection of simulated complete dentures...
  70. ncbi Low-shrinkage dental restorative composite: modeling viscoelastic behavior during setting
    Bibi S Dauvillier
    Department of Inorganic Chemistry and Catalysis, Debije Institute, Utrecht University, Sorbonnelaan 16, NL 3584 CA Utrecht, The Netherlands
    J Biomed Mater Res B Appl Biomater 73:129-39. 2005
    ..Evaluation tests of their potential as restorative material are required, to examine if the biocompatibility and mechanical properties after setting of oxirane composites are acceptable for dental use...
  71. ncbi A histological and immunohistochemical study of tissue reactions to solid poly(ortho ester) in rabbits
    M Ekholm
    Department of Oral and Maxillofacial Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Int J Oral Maxillofac Surg 35:631-5. 2006
    ..Resorption times and the effect of 2 different sterilization methods (gamma radiation and ethylene oxide) upon resorption were also evaluated...
  72. ncbi Comparison of the effects of sterilisation techniques on subsequent DNA profiling
    Kirsty Shaw
    Department of Forensic Science and Drug Monitoring, King s College London, London, SE1 9NH, UK
    Int J Legal Med 122:29-33. 2008
    ..Four sterilisation techniques (UV, gamma and beta radiation and ethylene oxide treatment) were examined for their potential to degrade contaminating DNA to such an extent that subsequent ..
  73. ncbi Resterilization of instruments used in a hospital-based oral and maxillofacial surgery clinic
    Nicholas J V Hogg
    Department of Oral and Maxillofacial Sciences, Faculty of Dentistry, Dalhousie University, Halifax, Nova Scotia
    J Can Dent Assoc 71:179-82. 2005
    ..The purpose of this study was to investigate the rate of bacterial contamination of instruments resterilized for use in oral and maxillofacial procedures in a hospital-based clinic...
  74. ncbi Gamma irradiation and ethylene oxide in the sterilization of native reindeer bone morphogenetic protein extract
    T Pekkarinen
    Bone Transplantation Research Group, Department of Orthopaedic and Trauma Surgery, University of Oulu, P O Box 5000, FIN 90014 Oulu, Finland
    Scand J Surg 94:67-70. 2005
    ..We compared the effects of ethylene oxide and gamma irradiation in the sterilization of native reindeer BMP extract with regard to bone induction in the ..
  75. ncbi Use of peracetic acid to sterilize human donor skin for production of acellular dermal matrices for clinical use
    Qizhi Huang
    Medical Cryobiology Unit, Department of Biology, The University of York, York, United Kingdom
    Wound Repair Regen 12:276-87. 2004
    ..In a comparison of gamma-irradiation, glycerol, and ethylene oxide, sterilization with ethylene oxide after treatment with glycerol provided the most satisfactory dermis in ..
  76. ncbi Polycationic block copolymers of poly(ethylene oxide) and poly(propylene oxide) for cell transfection
    Lev Bromberg
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Bioconjug Chem 16:626-33. 2005
    ..poly(2-N-(dimethylaminoethyl) methacrylate) (pDMAEMA) and copolymers of poly(propylene oxide) (PPO) and poly(ethylene oxide) (PEO) has been developed...
  77. ncbi Ethylene oxide sterilization of autologous bone flaps following decompressive craniectomy
    P Missori
    Neurosurgery and Neurotraumatology, Neuroradiology II and Department of Clinical Medicine, University of Rome La Sapienza, Italy
    Acta Neurochir (Wien) 145:899-902; discussion 902-3. 2003
    ..In patients undergoing decompressive craniectomy, the bone flap is temporarily preserved either in the subcutaneous tissue of the patient or frozen. However, there are some drawbacks related to these methods...
  78. ncbi [Influence of processing and sterilization on the mechanical properties of pins made from bovine cortical bone]
    C Hofmann
    Klinik für Unfall, Wiederherstellungs und Handchirurgie, Philipps Universitat, Marburg
    Unfallchirurg 106:478-82. 2003
    ..three to five were treated with sodium chloride and acetone and afterwards sterilized by different means (ethylene oxide, autoclavation, or gamma radiation). All pins were subjected to a three-point-bending test and a shear test...
  79. ncbi Sterilisation of bioresorbable polymer implants
    M Bernkopf
    BBF Sterilisations service GmbH Kernen, Germany
    Med Device Technol 18:26, 28-9. 2007
    ..The suitability of different sterilisation methods for bioresorbable polymers is discussed using polylactic acid implants as an example...
  80. ncbi The effects of ethylene oxide and gas-plasma sterilization on failure strength and failure mode of pre-tied monofilament ligature loops
    Steven S Trostle
    Department of Surgical Sciences, University of Wisconsin, WI, USA
    Vet Surg 31:281-4. 2002
    To evaluate the effects of ethylene oxide and gas-plasma sterilization on the failure strength and failure mode of pre-tied monofilament ligature loops.
  81. ncbi Reprocessing of single-use endoscopic biopsy forceps and snares. One hospital's study
    D Hambrick
    Gastrointestinal Laboratory, Montclair Center for Digestive Diseases, Montclair Baptist Medical Center, 800 Montclair Road, Birmingham, AL 35213, USA
    Gastroenterol Nurs 24:112-5. 2001
    ..Reprocessing of the single-use devices tested did not result in endoscopic instruments that met acceptable standards for sterility at our institution...
  82. ncbi Safety of plasma-based sterilization: surface modifications of polymeric medical devices induced by Sterrad and Plazlyte processes
    S Lerouge
    Biomedical Engineering Institute, Ecole Polytechnique, Station Centre Ville, PO Box 6079, Montreal, Quebec H3C 3A7, Canada
    Biomed Mater Eng 12:3-13. 2002
    Plasma-based sterilization is a promising alternative to the use of pure ethylene oxide (EO), for low-temperature clinical sterilization of medical instruments and devices...
  83. ncbi Effects of the sterilisation method on the wear of UHMWPE acetabular cups tested in a hip joint simulator
    S Affatato
    Laboratorio di Tecnologia Medica, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 23:1439-46. 2002
    ..This study was performed to investigate the effects of the sterilisation method (gamma irradiation and ethylene oxide treatment) on the wear and on the changes in physical properties of polyethylene acetabular cups...
  84. ncbi Effects of ethylene oxide gas sterilization on physical properties of poly(L-lactide)-poly(ethylene glycol)-poly(L-lactide) microspheres
    Y C Ah
    Department of Materials Science and Engineering, Kwangju Institute of Science and Technology, Korea
    J Biomater Sci Polym Ed 12:783-99. 2001
    The aggregation of poly(alpha-hydroxy acid) microspheres during ethylene oxide (EO) gas sterilization makes it difficult for the microspheres to be used in clinical applications...
  85. ncbi Assessment of parameters associated to the risk of PVC catheter reuse
    D L Granados
    National University of San Juan, Institute of Chemical Engineering, , San Juan, Argentina
    J Biomed Mater Res 58:505-10. 2001
    ..b>Ethylene oxide hospital-reprocessed central venous catheter samples were obtained from the stock of a health-care institution...
  86. ncbi Decomposition of ethylene oxide in the RF plasma environment
    W T Liao
    Department of Environmental Engineering, National Cheng Kung University, Tainan 70101, Taiwan
    Environ Technol 22:165-73. 2001
    A radio frequency (RF) plasma system was used to decompose the ethylene oxide (EO) contained gas in the EO/Ar, and EO/O2/Ar system, respectively...
  87. ncbi Block lengths and block sequence of linear triblock and glycerol derivative diblock copolyethers by electrospray ionization--collision-induced dissociation mass spectrometry
    Peran Terrier
    Laboratoire Analyse et Modelisation pour la Biologie et l Environnement, Universite d Evry Val d Essonne, CNRS UMR 8587, Bat Maupertuis, Bd F Mitterrand, 91025 Evry Cedex, France
    Anal Chem 78:1801-6. 2006
    Chemical properties of ethylene oxide (EO) and propylene oxide (PO) block copolymers are strongly dependent on their sequence. Useful information about copolymer sequence can be obtained by tandem mass spectrometry (MS/MS)...
  88. ncbi Exposure of hematopoietic stem cells to ethylene oxide during processing represents a potential carcinogenic risk for transplant recipients
    Byron E Butterworth
    Butterworth Consulting, 4820 Regalwood Dr, Raleigh, NC 27613, USA
    Regul Toxicol Pharmacol 49:149-53. 2007
    ..Sterilization of disposables with ethylene oxide is widespread, even though those sets unavoidably retain residual amounts of ethylene oxide which is a potent, ..
  89. ncbi Round-robin evaluation of a solid-phase microextraction-gas chromatographic method for reliable determination of trace level ethylene oxide in sterilized medical devices
    Thomas Harper
    Sterile Process Technologies SPT, a Division of the Johnson and Johnson Corp, Route 1 and Commerce Blvd, North Brunswick, NJ 08902, USA
    Biomed Chromatogr 22:136-48. 2008
    Medical devices that are sterilized with ethylene oxide (EtO) retain small quantities of EtO residuals, which may cause negative systemic and local irritating effects, and must be accurately quantified to ensure non-toxicity...
  90. ncbi Purification of protein and recycling of polymers in a new aqueous two-phase system using two thermoseparating polymers
    J Persson
    Department of Biochemistry, Lund University, Sweden
    J Chromatogr A 864:31-48. 1999
    ..The polymers used in this work are EO50PO50, a random copolymer of 50% ethylene oxide (EO) and 50% propylene oxide (PO), and a hydrophobically modified random copolymer of EO and PO with aliphatic ..
  91. ncbi [Influence of sterilization treatments on continuous carbon-fiber reinforced polyolefin composite]
    Shi bing Guan
    Department of Orthopedic Surgery, Second Affiliated Hospital of Shandong University, Jinan, China
    Zhonghua Yi Xue Za Zhi 87:2228-31. 2007
    ..To evaluate the influence of sterilization treatment on continuous carbon-fiber reinforced polyolefin composite (CFRP) so as to provide experimental reference for selection of sterilization method for CFRP...
  92. doi In vivo change of elastic property in polyethylene acetabular components
    Atsushi Kusaba
    Institute of Joint Replacement and Rheumatology, Ebina General Hospital, Ebina, Kanagawa, Japan
    Mod Rheumatol 18:140-5. 2008
    ..Thirty-two cups were sterilized by gamma irradiation in air and 24 by ethylene oxide gas (EtO)...
  93. ncbi Effects of sterilization on an extracellular matrix scaffold: part I. Composition and matrix architecture
    Jason Hodde
    Cook Biotech Incorporated, 1425 Innovation Place, West Lafayette, IN 47906, USA
    J Mater Sci Mater Med 18:537-43. 2007
    The impact of peracetic acid (PAA), lyophilization, and ethylene oxide (EO) sterilization on the composition and three dimensional matrix structure of small intestinal submucosa (SIS), a biologic scaffold used to stimulate the repair of ..
  94. ncbi Impact of sterilization on the porous design and cell behavior in collagen sponges prepared for tissue engineering
    Ernst Magnus Noah
    Department of Plastic, Hand, and Burn Surgery, Technology University of Aachen, Germany
    Biomaterials 23:2855-61. 2002
    ..Collagen sponges with uniform pore size (20 microm) were sterilized either with ethylene oxide (EO) or gamma irradiation (2.5 Mrad)...
  95. ncbi Effects of ethylene oxide and steam sterilization on dialysis-induced cytokine release by cuprophan membrane
    Filippo Aucella
    Department of Nephrology and Dialysis, Casa Sollievo della Sofferenza Hospital Istituto di Ricovero e Cura a Carattere Scientifico, San Giovanni Rotondo FG, Italy
    Artif Organs 26:543-5. 2002
    ..They were using a 1.3 m2 ethylene oxide (E3) or steam (E3S) sterilized Cuprophan membrane...
  96. ncbi Prepared endotracheal tubes: are they a potential source for pathogenic microorganisms?
    Nivez F Rasic
    Department of Anesthesia, St Boniface General Hospital, Winnipeg, Manitoba, Canada
    Anesth Analg 97:1133-6, table of contents. 2003
    ..A stylet was inserted into a 7-mm ETT, and this system was ethylene oxide sterilized. The PETTs were placed in 20 different locations and sampled 8 times in a 4-wk period...
  97. ncbi [Allogeneic implantation of the tendon tissue sterilized with gaseous ethylene oxide in experiment]
    V I Savel'ev
    Vestn Khir Im I I Grek 162:61-3. 2003
    The implantation of the allo-tendon tissue sterilized with gaseous ethylene oxide was carried out in 51 while rats...
  98. ncbi Absorbable sandwich-like membrane for retinal-sheet transplantation
    Ging Ho Hsiue
    Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan 30043, Republic of China
    J Biomed Mater Res 61:19-25. 2002
    ..Three sterilization methods were conducted, with hydrogen peroxide gas plasma (HPGP), ethylene oxide (EO), and gamma-ray irradiation (gamma). The results were compared with those of a control (no disinfection)...
  99. ncbi Long-term in vivo wear performance of porous-coated acetabular components sterilized with gamma irradiation in air or ethylene oxide
    Karl F Orishimo
    Anderson Orthopaedic Research Institute, Alexandria, VA 22306, USA
    J Arthroplasty 18:546-52. 2003
    ..28 hips implanted with Arthropor cups (Joint Medical Products, Stamford, CT) that were sterilized with ethylene oxide. Time-dependent variations in the radiographic wear rates were compared within each group...
  100. ncbi Technical views
    Helene Olefsky
    Nephrol News Issues 17:12. 2003
  101. ncbi Effects of sterilisation method on surface topography and in-vitro cell behaviour of electrostatically spun scaffolds
    Kirstie D Andrews
    UK Centre for Tissue Engineering, Division of Clinical Engineering, Duncan Building, Daulby Street, University of Liverpool, Liverpool, L69 3GA, UK
    Biomaterials 28:1014-26. 2007
    ..Scaffolds made from Tecoflex SG-80A polyurethane were sterilised using ethylene oxide and UV-ozone...

Research Grants72

  1. INFLAMATION AND INFECTION ON BIOMATERIALS
    ERIC KALER; Fiscal Year: 2001
    ..SAMs will be synthesized with various functionalities including ethylene oxide, phosphorylcholine, and the Arg-Gly-Asp peptide sequence...
  2. A New Method for Sterilizing Biomedical Materials
    PENNY STARKEY; Fiscal Year: 2002
    ..that would be compatible with emerging biomaterials and biomimetic structures and would eventually replace ethylene oxide as a sterilization method. In particular, sterilization of the new synthetic extracellular matrix, a.k.a...
  3. Prospective studies of cancer etiology and prevention in Shanghai and Singapore
    Jian Min Yuan; Fiscal Year: 2010
    ..assess the independent role of polycyclic aromatic hydrocarbons (PAH), 1,3-butadiene, acrolein, benzene, and ethylene oxide in the development of lung cancer among smokers;(2) to assess independent role of PAH, 1,3-butadiene, acrolein,..
  4. Terminal Sterilization of Tendon Allografts Using Supercritical CO2- Phase II
    Renee Christopher; Fiscal Year: 2007
    ..The only two processes capable of terminal sterilization of allografts are ethylene oxide and gamma irradiation which suffer from major drawbacks if used at a concentration to achieve SAL6 thus ..
  5. DNA cross-linking by diepoxybutane
    Natalia Y Tretyakova; Fiscal Year: 2010
    ..We will analyze the formation of diepoxybutane -DNA adducts in laboratory animals exposed to BD and examine their ability to induce DNA mutations. ..
  6. DNA cross-linking by diepoxybutane
    Natalia Y Tretyakova; Fiscal Year: 2011
    ..We will analyze the formation of diepoxybutane -DNA adducts in laboratory animals exposed to BD and examine their ability to induce DNA mutations. ..
  7. NEW SYNTHETIC REACTIONS FOR ACTIVE PRINCIPLES
    Samuel Danishefsky; Fiscal Year: 1993
    ..Finally we hope to use these findings and the chemistry we have developed to develop a program directed to solic phase syntheses of oligosaccharides an glycoconjugates...
  8. HIGH-PERFORMANCE STERILANT GAS FOR DIALYSIS MEMBRANES
    JONATHAN NIMITZ; Fiscal Year: 2005
    ..The new sterilant gas should be marketable worldwide and should allow use of existing ethylene oxide (EO) sterilizing equipment, thus reducing costs of medical care...
  9. ARTIFICIAL POLYMERIC LIPOPROTEINS AS DRUG CARRIERS
    GLEN KWON; Fiscal Year: 2006
    ..must be made with an individual drug or class of drugs in mind, and that easily made adjustments on poly(ethylene oxide)-block-poly(L-amino acid) (PEG-b-PLAA) micelles may enhance drug delivery...
  10. ARTIFICIAL POLYMERIC LIPOPROTEINS AS DRUG CARRIERS
    GLEN KWON; Fiscal Year: 2003
    ..must be made with an individual drug or class of drugs in mind, and that easily made adjustments on poly(ethylene oxide)-block-poly(L-amino acid) (PEG-b-PLAA) micelles may enhance drug delivery...
  11. Engineered Spores as Fluorogenic Biological Indicators for Sterility Testing
    Boris Rotman; Fiscal Year: 2007
    ..Task 3. Conduct experiments designed to extend the use of F-spores for sterilization processes using ethylene oxide, hydrogen peroxide gas plasma, and radiation...
  12. OVERALL HEMOCOMPATIBILITY PEO-FUNCTIONALIZED SILOXANES
    William Collins; Fiscal Year: 2003
    ..the biocompatibility of an exciting family of biomaterials, polydimethylsiloxanes end-functionalized with poly(ethylene oxide) (PEO siloxanes), to further such design...
  13. Smart Lidocaine Gels for Pain Management
    CHIRAKKAL KRISHNAN; Fiscal Year: 2007
    ..smart gels, containing lidocaine (an anesthetic drug) and mixtures of pluronic-based block copolymers (poly (ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide)) in water, can be fine-tuned by copolymer composition and ..
  14. Cross-linked Polymer Micelles in Cancer Therapy
    TATIANA BRONICH; Fiscal Year: 2007
    ..The nanofabrication of these micelles involves condensation of diblock copolymers of poly(ethylene oxide) (PEO) and poly(carboxylic acid) by divalent metal cations into spherical micelles of core-shell morphology...
  15. In-Vivo Study of an Oxirane Low Shrink-Stress Composite
    JOHN PURK; Fiscal Year: 2007
    ....
  16. Cross-linked Polymer Micelles in Cancer Therapy
    TATIANA BRONICH; Fiscal Year: 2009
    ..The nanofabrication of these micelles involves condensation of diblock copolymers of poly(ethylene oxide) (PEO) and poly(carboxylic acid) by divalent metal cations into spherical micelles of core-shell morphology...
  17. Cross-linked Polymer Micelles in Cancer Therapy
    Tatiana K Bronich; Fiscal Year: 2010
    ..The nanofabrication of these micelles involves condensation of diblock copolymers of poly(ethylene oxide) (PEO) and poly(carboxylic acid) by divalent metal cations into spherical micelles of core-shell morphology...
  18. Polypeptide modification for enhanced brain delivery
    ALEXANDER V contact KABANOV; Fiscal Year: 2010
    ..The goal is achieved by modification of polypeptides with Pluronic copolymers (poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide))...
  19. Tape Mechanical Occlusive Device (TMOD)
    GERALD TIMM; Fiscal Year: 2006
    ..b>Ethylene Oxide sterilization processes will be validated during the course of the grant and used to sterilize TMOD devices in ..
  20. High and Low Frequency Scanning Acoustic Microscopes
    Paulette Spencer; Fiscal Year: 2002
    ..These measurements will e completed not only on the same specimen but the same small region of the interface. ..
  21. Enhanced Management of Ethylene Oxide Sterilizers
    Sudipto Majumdar; Fiscal Year: 2005
    The effectiveness of ethylene oxide (EtO) for destroying pathogens in the case of heat and moisture sensitive materials has led to its wide spread use in sterilization processes...
  22. Three-Membered Ring Metabolites, Inhibition & Formation
    Hung wen Liu; Fiscal Year: 2006
    ..Thus, our results are expected to contribute to the broad field of bioorganic chemistry and also hold potential for future clinical applications. ..
  23. INTERACTIONS OF BLOCK COPOLYMERS IN BLOOD BRAIN BARRIERS
    Alexander Kabanov; Fiscal Year: 2000
    DESCRIPTION (applicants abstract): The micelles formed by poly(ethylene oxide)-poly(propylene oxide) block copolymers (Pluronic) have been used to enhance the transport of certain agents to the brain in vivo...